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- Antibody Data
- Antigen structure
- References [121]
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- Western blot [1]
- Immunocytochemistry [1]
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- Product number
- 15421-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#15421-1-AP, RRID:AB_2223741
- Product name
- ACLY antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated ACLY antibody (Cat. #15421-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The D826V point mutation in IREB2 induces lipogenesis in adipose tissues.
Hepatic IFRD1 suppresses metabolic dysfunction-associated fatty liver disease via GLUD1/α-KG axis.
Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis.
ATP-citrate lyase is a critical regulator of physiological and pathological angiogenesis.
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
SLC7A5-ERBB2 axis drives olaparib resistance via de novo lipid synthesis in ovarian cancer.
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase.
The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis.
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Macrophage-derived IL-6 reprograms lipid metabolism to promote colorectal cancer development through USP14-mediated FASN deubiquitination.
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression.
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle.
Light-Activated CD36-Targeted Cuproptosis Triggers Metabolic-Immune Synergy for Precision Breast Cancer Therapy.
Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis.
ACSS2 involved in acetyl-CoA synthesis regulates skeletal muscle function.
TRIM34 inhibits triple-negative breast cancer progression by attenuating fatty acid synthesis via facilitating FASN ubiquitination.
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation.
ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway.
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Leucine 7 is a key residue for mutant huntingtin-induced mitochondrial pathology and neurotoxicity in Huntington's disease.
Enhanced LDL uptake and PPARα signaling support OSCC cell survival under glutamine deprivation.
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones.
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase.
Integrated proteogenomic characterization of ampullary adenocarcinoma.
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.
Lactamase β reprograms lipid metabolism to inhibit the progression of endometrial cancer through attenuating MDM2-mediated p53 ubiquitination and degradation.
SUCLG1 promotes aerobic respiration and progression in plexiform neurofibroma.
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis.
Synergistic Promotion of Triple-Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella-Derived Glutamate and Platelet Activation.
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress.
Hypoxia-induced USP13 expression drives ferroptosis resistance and tumor immune evasion in hepatocellular carcinoma through the stabilization of ACLY.
Integrated analysis of lactylation modification and proteomics revealed potential epigenetic regulation in intramuscular fat deposition of Xidu black pigs.
Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis.
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis.
SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression.
MOSPD1 facilitates fatty acid metabolism and gastric cancer progression by promoting the MAPK pathway.
Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor.
Compound heterozygous RYR1-RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival.
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease.
Compensatory activity of the PC-ME1 metabolic axis underlies differential sensitivity to mitochondrial complex I inhibition.
Characteristics of Myocardial Structure and Central Carbon Metabolism during the Early and Compensatory Stages of Cardiac Hypertrophy.
Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy.
Anti-Obesity Effects of Pleurotus ferulae Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice.
Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy.
Disease-associated astrocyte epigenetic memory promotes CNS pathology.
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY.
Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.
Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease.
Therapeutic targeting of ACLY in T-ALL in vivo.
ACLY alternative splicing correlates with cancer phenotypes.
Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites.
Disease-associated astrocyte epigenetic memory promotes CNS pathology.
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα.
The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis.
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.
ACLY promotes gastric tumorigenesis and accelerates peritoneal metastasis of gastric cancer regulated by HIF-1A.
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress.
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance.
Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment.
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis.
LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome.
Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells.
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
The enhancer RNA ADCY10P1 is associated with the progression of ovarian cancer.
The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma.
Albumin knockout mice exhibit reduced plasma free fatty acid concentration and enhanced insulin sensitivity.
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.
Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells.
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial-nuclear communication.
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt.
ER resident protein 44 promotes malignant phenotype in nasopharyngeal carcinoma through the interaction with ATP citrate lyase.
Nuclear-translocation of ACLY induced by obesity-related factors enhances pyrimidine metabolism through regulating histone acetylation in endometrial cancer.
Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration.
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate.
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
ACLY facilitates colon cancer cell metastasis by CTNNB1.
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females.
Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism.
Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice.
Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory.
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection.
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma.
Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.
Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1.
Lv Y, Wu C, Xiao J, Yang W, Wang C, Wang J, Huang J, Guo Z, Liao S
Frontiers in cell and developmental biology 2026;14:1724485
Frontiers in cell and developmental biology 2026;14:1724485
Hepatic IFRD1 suppresses metabolic dysfunction-associated fatty liver disease via GLUD1/α-KG axis.
Geng M, Meng F, Li H, Sun L, Sun X, Ding Y, Shi R, Wang Z, Huang Y, Wang J, Liu Y, Wang J, Little PJ, Xu S, Liu L, Weng J, Luo S
Science bulletin 2026 May 15;71(9):2283-2299
Science bulletin 2026 May 15;71(9):2283-2299
Apocrine carcinoma of the breast: distinctive metabolic reprogramming and high-frequency PIK3CA mutations revealed by molecular and immunohistochemical analysis.
Nakamura H, Kukita Y, Kittaka N, Kusama H, Nakayama T, Tamaki Y, Yoshida KI, Kunimasa K, Imamura F, Yagi T
Histopathology 2026 Mar;88(4):790-809
Histopathology 2026 Mar;88(4):790-809
ATP-citrate lyase is a critical regulator of physiological and pathological angiogenesis.
Xu C, Lin Y, Wang Z, Feng C, Luo L, Guo S, Zhang H, Liu L, Fan A, Qi P, Jiang D, Xu Y, Xu Y, Li W, Che W, Xu S, Zhu G
Angiogenesis 2026 Mar 4;29(2)
Angiogenesis 2026 Mar 4;29(2)
Cytosolic acetyl-coenzyme A is a signalling metabolite to control mitophagy.
Zhang Y, Shen X, Shen Y, Wang C, Yu C, Han J, Cao S, Qian L, Ma M, Huang S, Wen W, Yin M, Lei QY
Nature 2026 Jan;649(8098):1022-1031
Nature 2026 Jan;649(8098):1022-1031
SLC7A5-ERBB2 axis drives olaparib resistance via de novo lipid synthesis in ovarian cancer.
Liu S, He Y, Ning X, Xu W, Hu X, Qin L, Yang Y, Chen X, Ma R
Oncogene 2026 Jan;45(2):140-263
Oncogene 2026 Jan;45(2):140-263
Narirutin Reprograms Fatty Acid Metabolism and Inhibits Tumorigenesis via Downregulating ADORA3 Expression in Colorectal Cancer.
Wang H, Jiang R, Liu C, Chen F
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Journal of gastroenterology and hepatology 2026 Jan;41(1):202-214
Maternal Fructose Intake During Pregnancy Induced the Hepatic Glucose Homeostasis Imbalance in the Offspring by Inhibiting Glucokinase.
Miao Y, Meng Z, Chen S, Li X, Fang T, Deng X, Sun B, Chen L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 31;40(2):e71426
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Jan 31;40(2):e71426
The UFL1-AKT positive feedback loop promotes breast cancer progression by enhancing lipid synthesis.
Meng F, Du Y, Liang J, Li H, Wang J, Tang K, Kong R, Sun H, Yin T, Qin J, Yang X, Shan C, Liu M, Yang G, Zhang J, Wang Y, Zhou J, Chen Y
Nature communications 2026 Jan 20;17(1):614
Nature communications 2026 Jan 20;17(1):614
Combination of GLP-1 receptor agonist and Akkermansia muciniphila Akk11 reduces adiposity and ameliorates MASLD in T2D mice.
Gao K, Yin Z, Zhang C, Dong Z, Wang R, Chen Q, Liu X, Jiang C, Wang Y, Guo B, Zhou Z, Jia Z, Sun H, Feng Y
Cell & bioscience 2026 Jan 12;16(1):18
Cell & bioscience 2026 Jan 12;16(1):18
Macrophage-derived IL-6 reprograms lipid metabolism to promote colorectal cancer development through USP14-mediated FASN deubiquitination.
Yunxin L, Xirui X, Xinyi Z, Chenjing W, Ting Z, Kanghui F, Haixia Y, Zude C, Wan H, Yubing Z, Xianjun F
Journal of translational medicine 2026 Feb 26;24(1)
Journal of translational medicine 2026 Feb 26;24(1)
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression.
Zhen L, Min M, Mo X, Zhao G, Li H, Liu M, Wan L, Yang X, Huang L, Zhang Y, Gao Q, Zhong H, Qiang G, Wu F, Xie Q, Wei C, Zhao R
Journal of advanced research 2026 Apr;82:765-783
Journal of advanced research 2026 Apr;82:765-783
Citrate clearance is a major function of aconitase 2 in the canonical TCA cycle.
Xie A, Brunner JS, Chakraborty S, Montero AM, Bridgeman AE, Paras KI, Cui R, Fagoaga-Eugui M, Komza M, Arnold PK, Jackson BT, Noriega Madrazo S, Atmane MI, Carrasco SE, Finley LWS
Cell 2026 Apr 30;189(9):2684-2699.e21
Cell 2026 Apr 30;189(9):2684-2699.e21
Light-Activated CD36-Targeted Cuproptosis Triggers Metabolic-Immune Synergy for Precision Breast Cancer Therapy.
Wang S, Shen Y, Hu B, Wu Q, Wang N, Wang Z, Zhang Z, Li Y, Jiang J
ACS applied materials & interfaces 2025 Sep 10;17(36):50317-50336
ACS applied materials & interfaces 2025 Sep 10;17(36):50317-50336
Focal adhesion kinase/Src family kinase axis-mediated tyrosine phosphorylation of metabolic enzymes facilitates tumor metastasis.
Chen J, Zhang J, Zhu Y, Zhu Y, Pang J, Wu Q, Wang Y, Zhan Q
Signal transduction and targeted therapy 2025 Sep 1;10(1):280
Signal transduction and targeted therapy 2025 Sep 1;10(1):280
ACSS2 involved in acetyl-CoA synthesis regulates skeletal muscle function.
Gunasekaran M, Campos G, Wells NM, Lambuu K, Draper I, Pacak CA, Kang PB
FEBS letters 2025 Oct;599(19):2817-2827
FEBS letters 2025 Oct;599(19):2817-2827
TRIM34 inhibits triple-negative breast cancer progression by attenuating fatty acid synthesis via facilitating FASN ubiquitination.
Li Y, Shan J, Liu S, Shen Y, Niu L, Mao Q, Chen X
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167958
Biochimica et biophysica acta. Molecular basis of disease 2025 Oct;1871(7):167958
Bergamot Polyphenols Reduce Hepatic Lipogenesis While Boosting Autophagy and Short-Chain Fatty Acid Production in a Murine "Cafeteria" Model of MASLD.
Riillo C, Parafati M, Crupi F, Fotschki B, Ragusa M, Di Vito A, Mignogna C, Mollace V, Janda E
Nutrients 2025 Nov 25;17(23)
Nutrients 2025 Nov 25;17(23)
RNF180 suppressed aggressiveness by degrading NOTCH1, TRIM24 and FOXC1, and chemoresistance by degrading ACC1 and ACLY in colorectal cancer.
Li N, Zhang R, Zhao XX, Zhou L, Li YL, Cui ZG, Zheng HC
International immunopharmacology 2025 Nov 14;165:115445
International immunopharmacology 2025 Nov 14;165:115445
ACLY promotes NK cell effector function by regulating glycolysis and histone acetylation.
Sohn H, Kolicheski A, Poursine-Laurent J, Tran J, Wang Y, Gan K, Tobin JM, Saucier N, Fehniger TA, Payton JE, Cooper MA
Journal of immunology (Baltimore, Md. : 1950) 2025 Nov 1;214(11):3100-3114
Journal of immunology (Baltimore, Md. : 1950) 2025 Nov 1;214(11):3100-3114
ARMC10 Drives Glioblastoma Progression Through Activating Notch Pathway.
Feng B, Gao T, Chen L, Xing Y
Molecular carcinogenesis 2025 May;64(5):883-896
Molecular carcinogenesis 2025 May;64(5):883-896
SLC25A1 and ACLY maintain cytosolic acetyl-CoA and regulate ferroptosis susceptibility via FSP1 acetylation.
Li W, Han J, Huang B, Xu T, Wan Y, Luo D, Kong W, Yu Y, Zhang L, Nian Y, Chu B, Yin C
The EMBO journal 2025 Mar;44(6):1641-1662
The EMBO journal 2025 Mar;44(6):1641-1662
Leucine 7 is a key residue for mutant huntingtin-induced mitochondrial pathology and neurotoxicity in Huntington's disease.
Zhang S, Wang S, Yang Z, Li Y, Li J, Chen X, Yao H, Zheng Z, Guo X
The Journal of biological chemistry 2025 Mar;301(3):108297
The Journal of biological chemistry 2025 Mar;301(3):108297
Enhanced LDL uptake and PPARα signaling support OSCC cell survival under glutamine deprivation.
Cai L, Chen Y, Tang S, Wang Q, Xu Y, Pan Y, Yang F, Chen T, Chen Q, Zhou Y, Shen YQ
Medical oncology (Northwood, London, England) 2025 Jul 14;42(8):332
Medical oncology (Northwood, London, England) 2025 Jul 14;42(8):332
A hierarchical hepatic de novo lipogenesis substrate supply network utilizing pyruvate, acetate, and ketones.
Rauckhorst AJ, Sheldon RD, Pape DJ, Ahmed A, Falls-Hubert KC, Merrill RA, Brown RF, Deshmukh K, Vallim TA, Deja S, Burgess SC, Taylor EB
Cell metabolism 2025 Jan 7;37(1):255-273.e6
Cell metabolism 2025 Jan 7;37(1):255-273.e6
Bempedoic acid suppresses diet-induced hepatic steatosis independently of ATP-citrate lyase.
Liu JY, Kuna RS, Pinheiro LV, Nguyen PTT, Welles JE, Drummond JM, Murali N, Sharma PV, Supplee JG, Shiue M, Zhao S, Farria AT, Kumar A, Ruchhoeft ML, Demetriadou C, Kantner DS, Chatoff A, Megill E, Titchenell PM, Snyder NW, Metallo CM, Wellen KE
Cell metabolism 2025 Jan 7;37(1):239-254.e7
Cell metabolism 2025 Jan 7;37(1):239-254.e7
Integrated proteogenomic characterization of ampullary adenocarcinoma.
Zhang Q, Xu X, Jiang D, Wang Y, Wang H, Zhu J, Tang S, Wang R, Zhao S, Li K, Feng J, Xiang H, Yao Z, Xu N, Fang R, Guo W, Liu Y, Hou Y, Ding C
Cell discovery 2025 Jan 7;11(1):2
Cell discovery 2025 Jan 7;11(1):2
Sodium butyrate regulates macrophage polarization by TGR5/β-arrestin2 in vitro.
Liu M, Xie WJ, Zhang X, Wu W, Li G, Wang L
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31
Molecular medicine (Cambridge, Mass.) 2025 Jan 29;31(1):31
Lactamase β reprograms lipid metabolism to inhibit the progression of endometrial cancer through attenuating MDM2-mediated p53 ubiquitination and degradation.
Zhou T, Li X, Zhao F, Zhou J, Sun B
Archives of biochemistry and biophysics 2025 Feb;764:110287
Archives of biochemistry and biophysics 2025 Feb;764:110287
SUCLG1 promotes aerobic respiration and progression in plexiform neurofibroma.
Zhou Z, Li Q, Huo R
International journal of oncology 2025 Feb;66(2)
International journal of oncology 2025 Feb;66(2)
Acetyl-CoA synthesis in the skin is a key determinant of systemic lipid homeostasis.
Nguyen PTT, Shiue M, Kuprasertkul N, Costa-Pinheiro P, Izzo LT, Pinheiro LV, Affronti HA, Gugiu G, Ghaisas S, Liu JY, Harris JC, Bradley CW, Seykora JT, Yang X, Kambayashi T, Mesaros C, Capell BC, Wellen KE
Cell reports 2025 Feb 25;44(2):115284
Cell reports 2025 Feb 25;44(2):115284
Synergistic Promotion of Triple-Negative Breast Cancer Tumorigenesis and Metastasis by Oral Polystyrene Nanoplastics Exposure via Alloprevotella-Derived Glutamate and Platelet Activation.
Zhu L, Xu P, Zhou M, Li K, Tian S, Fan X, Liu J, Ye B, Ding Z, Shen Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e08310
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Dec;12(46):e08310
Disruption of cerebral cholesterol homeostasis by PS-NPs: astrocytic endoplasmic reticulum stress.
Tian L, Wei Y, Ma J, Zhao Y, Mi Y, Zhang L, Wang B, Chen J, Li K, Shi Y, Lai W, Liu H, Lin B
Journal of nanobiotechnology 2025 Dec 24;23(1):790
Journal of nanobiotechnology 2025 Dec 24;23(1):790
Hypoxia-induced USP13 expression drives ferroptosis resistance and tumor immune evasion in hepatocellular carcinoma through the stabilization of ACLY.
Hu K, Li J, Chen K, Mi X, Pan Y, Tang J, Cao J, Zhong X
Cell death discovery 2025 Dec 2;12(1):28
Cell death discovery 2025 Dec 2;12(1):28
Integrated analysis of lactylation modification and proteomics revealed potential epigenetic regulation in intramuscular fat deposition of Xidu black pigs.
Chen T, Zhou J, Li M, Li Z, Feng Y, Qiao M, Xu Z, Chen D, Sun H, Peng X, Wu J, Mei S
BMC genomics 2025 Dec 18;27(1):86
BMC genomics 2025 Dec 18;27(1):86
Gastrodin attenuates high fructose-induced sweet taste preference decrease by inhibiting hippocampal neural stem cell ferroptosis.
Tang CF, Ding H, Wu YQ, Miao ZA, Wang ZX, Wang WX, Pan Y, Kong LD
Journal of advanced research 2025 Aug;74:429-442
Journal of advanced research 2025 Aug;74:429-442
Spautin-1 inhibits the growth of diffuse large B-cell lymphoma by inducing mitochondrial damage-mediated PANoptosis and anti-tumor immunity.
Wu J, Deng Y, Gao Y, Wei B
Cancer immunology, immunotherapy : CII 2025 Aug 25;74(9):293
Cancer immunology, immunotherapy : CII 2025 Aug 25;74(9):293
Pancreatic cancer cachexia is mediated by PTHrP-driven disruption of adipose de novo lipogenesis.
Bhalerao N, Ogoti Y, Peura J, Johnson C, Chen Q, Korobkina ED, Keller FN, Wengyn M, Norgard RJ, Shamber C, Klute K, DiMaio D, Sellin K, Grandgenett PM, Li R, Hollingsworth MA, Guilherme A, Czech MP, Kremer R, Zhu LJ, Spinelli JB, Watson EV, Ruscetti M, Guertin DA, Pitarresi JR
bioRxiv : the preprint server for biology 2025 Aug 20;
bioRxiv : the preprint server for biology 2025 Aug 20;
SESN2 maintains cartilage homeostasis by SREBP1-mediated lipid metabolism during osteoarthritis progression.
Liu Z, Jiang H, Zhang Z, Jiang R, Wang R, Li J, Li W, Tan G, Fei Y, Lv Z, Guo H, Sun Z, Wu R, Shi H, Shi D
iScience 2025 Aug 15;28(8):113097
iScience 2025 Aug 15;28(8):113097
MOSPD1 facilitates fatty acid metabolism and gastric cancer progression by promoting the MAPK pathway.
Wang C, Qiu Y, Zheng X, Chen S, He C
Tissue & cell 2025 Apr;93:102752
Tissue & cell 2025 Apr;93:102752
Baicalin alleviates lipid accumulation in adipocytes via inducing metabolic reprogramming and targeting Adenosine A1 receptor.
Zhang Z, Wang R, Cai J, Li X, Feng X, Xu S, Jiang Z, Lin P, Huang Z, Xie Y
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108339
Toxicon : official journal of the International Society on Toxinology 2025 Apr;258:108339
Compound heterozygous RYR1-RM mouse model reveals disease pathomechanisms and muscle adaptations to promote postnatal survival.
Liang C, Malik S, He M, Groom L, Ture SK, O'Connor TN, Morrell CN, Dirksen RT
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct;38(20):e70120
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Oct;38(20):e70120
Lysine β-hydroxybutyrylation promotes lipid accumulation in alcoholic liver disease.
Chen N, Luo J, Zhou T, Shou Y, Du C, Song G, Xu L, Zhao K, Jin Y, Li C, Yu D
Biochemical pharmacology 2024 Oct;228:115936
Biochemical pharmacology 2024 Oct;228:115936
Compensatory activity of the PC-ME1 metabolic axis underlies differential sensitivity to mitochondrial complex I inhibition.
Del Prado L, Jaraíz-Rodríguez M, Agro M, Zamora-Dorta M, Azpiazu N, Calleja M, Lopez-Manzaneda M, de Juan-Sanz J, Fernández-Rodrigo A, Esteban JA, Girona M, Quintana A, Balsa E
Nature communications 2024 Oct 7;15(1):8682
Nature communications 2024 Oct 7;15(1):8682
Characteristics of Myocardial Structure and Central Carbon Metabolism during the Early and Compensatory Stages of Cardiac Hypertrophy.
Chen Y, Luo YM, Li D, Liu H, Luo X, Zhang X, Ling Y, Ouyang W
Journal of proteome research 2024 Oct 4;23(10):4229-4241
Journal of proteome research 2024 Oct 4;23(10):4229-4241
Morusin, a novel inhibitor of ACLY, induces mitochondrial apoptosis in hepatocellular carcinoma cells through ROS-mediated mitophagy.
Li D, Yuan X, Ma J, Lu T, Zhang J, Liu H, Zhang G, Wang Y, Liu X, Xie Q, Zhou L, Xu M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117510
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Nov;180:117510
Anti-Obesity Effects of Pleurotus ferulae Water Extract on 3T3-L1 Adipocytes and High-Fat-Diet-Induced Obese Mice.
Hong S, Park S, Lee J, Park S, Park J, Lee Y
Nutrients 2024 Nov 29;16(23)
Nutrients 2024 Nov 29;16(23)
Increasing membrane polyunsaturated fatty acids sensitizes non-small cell lung cancer to anti-PD-1/PD-L1 immunotherapy.
La Vecchia S, Fontana S, Salaroglio IC, Anobile DP, Digiovanni S, Akman M, Jafari N, Godel M, Costamagna C, Corbet C, Kopecka J, Riganti C
Cancer letters 2024 Nov 1;604:217221
Cancer letters 2024 Nov 1;604:217221
Disease-associated astrocyte epigenetic memory promotes CNS pathology.
Lee HG, Rone JM, Li Z, Akl CF, Shin SW, Lee JH, Flausino LE, Pernin F, Chao CC, Kleemann KL, Srun L, Illouz T, Giovannoni F, Charabati M, Sanmarco LM, Kenison JE, Piester G, Zandee SEJ, Antel JP, Rothhammer V, Wheeler MA, Prat A, Clark IC, Quintana FJ
Nature 2024 Mar;627(8005):865-872
Nature 2024 Mar;627(8005):865-872
SIRT2-mediated deacetylation of ACLY promotes the progression of oesophageal squamous cell carcinoma.
Zhang X, Xu Y, Li S, Qin Y, Zhu G, Zhang Q, Zhang Y, Guan F, Fan T, Liu H
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Journal of cellular and molecular medicine 2024 Mar;28(6):e18129
Pennogenin 3-O-β-Chacotrioside Attenuates Hypertrophied Lipid Accumulation by Enhancing Mitochondrial Oxidative Capacity.
Yu S, Lee HM, Lee J, Hwang JT, Choi HK, Lee YG
International journal of molecular sciences 2024 Mar 4;25(5)
International journal of molecular sciences 2024 Mar 4;25(5)
CILP2 promotes hypertrophic scar through Snail acetylation by interaction with ACLY.
Wang J, Du J, Wang Y, Song Y, Wu J, Wang T, Yu Z, Song B
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167202
Biochimica et biophysica acta. Molecular basis of disease 2024 Jun;1870(5):167202
Effects of endurance training under calorie restriction on energy substrate metabolism in mouse skeletal muscle and liver.
Takahashi K, Kitaoka Y, Hatta H
The journal of physiological sciences : JPS 2024 Jun 7;74(1):32
The journal of physiological sciences : JPS 2024 Jun 7;74(1):32
Dramatic Suppression of Lipogenesis and No Increase in Beta-Oxidation Gene Expression Are among the Key Effects of Bergamot Flavonoids in Fatty Liver Disease.
Parafati M, La Russa D, Lascala A, Crupi F, Riillo C, Fotschki B, Mollace V, Janda E
Antioxidants (Basel, Switzerland) 2024 Jun 25;13(7)
Antioxidants (Basel, Switzerland) 2024 Jun 25;13(7)
Therapeutic targeting of ACLY in T-ALL in vivo.
da Silva-Diz V, Singh A, Aleksandrova M, Kim O, Thai C, Lancho O, Nunes PR, Affronti H, Su X, Wellen KE, Herranz D
bioRxiv : the preprint server for biology 2024 Jun 20;
bioRxiv : the preprint server for biology 2024 Jun 20;
ACLY alternative splicing correlates with cancer phenotypes.
Supplee JG, Affronti HC, Duan R, Brooks RC, Stine ZE, Nguyen PTT, Pinheiro LV, Noji MC, Drummond JM, Huang K, Schultz K, Dang CV, Marmorstein R, Wellen KE
The Journal of biological chemistry 2024 Jul;300(7):107418
The Journal of biological chemistry 2024 Jul;300(7):107418
Thermostability-assisted limited proteolysis-coupled mass spectrometry for capturing drug target proteins and sites.
Yang L, Guo CW, Luo QM, Guo ZF, Chen L, Ishihama Y, Li P, Yang H, Gao W
Analytica chimica acta 2024 Jul 11;1312:342755
Analytica chimica acta 2024 Jul 11;1312:342755
Disease-associated astrocyte epigenetic memory promotes CNS pathology.
Lee HG, Rone JM, Li Z, Akl CF, Shin SW, Lee JH, Flausino LE, Pernin F, Chao CC, Kleemann KL, Srun L, Illouz T, Giovannoni F, Charabati M, Sanmarco LM, Kenison JE, Piester G, Zandee SEJ, Antel J, Rothhammer V, Wheeler MA, Prat A, Clark IC, Quintana FJ
bioRxiv : the preprint server for biology 2024 Jan 5;
bioRxiv : the preprint server for biology 2024 Jan 5;
Prepared Radix Polygoni Multiflori and emodin alleviate lipid droplet accumulation in nonalcoholic fatty liver disease through MAPK signaling pathway inhibition.
Huang C, Zhang Y, Xu Y, Wei S, Yang T, Wang S, Li C, Lin H, Li X, Zhao S, Zhu L, Pan W
Aging 2024 Jan 26;16(3):2362-2384
Aging 2024 Jan 26;16(3):2362-2384
Excessive SOX8 reprograms energy and iron metabolism to prime hepatocellular carcinoma for ferroptosis.
Yang X, Gu C, Cai J, Li F, He X, Luo L, Xiao W, Hu B, Hu J, Qian H, Ren S, Zhang L, Zhu X, Yang L, Yang J, Yang Z, Zheng Y, Huang X, Wang Z
Redox biology 2024 Feb;69:103002
Redox biology 2024 Feb;69:103002
SHMT2 reduces fatty liver but is necessary for liver inflammation and fibrosis in mice.
Chen G, Zhou G, Zhai L, Bao X, Tiwari N, Li J, Mottillo E, Wang J
Communications biology 2024 Feb 12;7(1):173
Communications biology 2024 Feb 12;7(1):173
Spatial multi-omics characterizes GPR35-relevant lipid metabolism signatures across liver zonation in MASLD.
Otkur W, Zhang Y, Li Y, Bao W, Feng T, Wu B, Ma Y, Shi J, Wang L, Pei S, Wang W, Wang J, Zhao Y, Liu Y, Li X, Xia T, Wang F, Chen D, Liang X, Piao HL
Life metabolism 2024 Dec;3(6):loae021
Life metabolism 2024 Dec;3(6):loae021
The facilitating effects of KRT80 on chemoresistance, lipogenesis, and invasion of esophageal cancer.
Yun WJ, Li J, Yin NC, Zhang CY, Cui ZG, Zhang L, Zheng HC
Cancer biology & therapy 2024 Dec 31;25(1):2302162
Cancer biology & therapy 2024 Dec 31;25(1):2302162
mTORC2 knockdown mediates lipid metabolism to alleviate hyperlipidemic pancreatitis through PPARα.
Wang X, Liu Y, Zhou Y, Li M, Mo T, Xu X, Chen Z, Zhang Y, Yang L
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23802
Journal of biochemical and molecular toxicology 2024 Aug;38(8):e23802
The proto-oncogene tyrosine kinase c-SRC facilitates glioblastoma progression by remodeling fatty acid synthesis.
Zhao W, Ouyang C, Zhang L, Wang J, Zhang J, Zhang Y, Huang C, Xiao Q, Jiang B, Lin F, Zhang C, Zhu M, Xie C, Huang X, Zhang B, Zhao W, He J, Chen S, Liu X, Lin D, Li Q, Wang Z
Nature communications 2024 Aug 28;15(1):7455
Nature communications 2024 Aug 28;15(1):7455
Patulin Ameliorates Hypertrophied Lipid Accumulation and Lipopolysaccharide-Induced Inflammatory Response by Modulating Mitochondrial Respiration.
Hong S, Park SK, Lee J, Park SH, Kim YS, Park JH, Yu S, Lee YG
Antioxidants (Basel, Switzerland) 2023 Sep 11;12(9)
Antioxidants (Basel, Switzerland) 2023 Sep 11;12(9)
ACLY promotes gastric tumorigenesis and accelerates peritoneal metastasis of gastric cancer regulated by HIF-1A.
Yan Z, Liu K, Xu P, Chen Z, Zhang P, Pei S, Cheng Q, Huang S, Li B, Lv J, Xu Z, Xu H, Yang L, Zhang D
Cell cycle (Georgetown, Tex.) 2023 Oct;22(20):2288-2301
Cell cycle (Georgetown, Tex.) 2023 Oct;22(20):2288-2301
Hepatic conversion of acetyl-CoA to acetate plays crucial roles in energy stress.
Wang J, Wen Y, Zhao W, Zhang Y, Lin F, Ouyang C, Wang H, Yao L, Ma H, Zhuo Y, Huang H, Shi X, Feng L, Lin D, Jiang B, Li Q
eLife 2023 Oct 30;12
eLife 2023 Oct 30;12
WTAP boosts lipid oxidation and induces diabetic cardiac fibrosis by enhancing AR methylation.
Song K, Sun H, Tu B, Zhou Y, Lin LC, Liu ZY, Li R, Yang JJ, Zhang Y, Zhao JY, Tao H
iScience 2023 Oct 20;26(10):107931
iScience 2023 Oct 20;26(10):107931
High dietary fructose promotes hepatocellular carcinoma progression by enhancing O-GlcNAcylation via microbiota-derived acetate.
Zhou P, Chang WY, Gong DA, Xia J, Chen W, Huang LY, Liu R, Liu Y, Chen C, Wang K, Tang N, Huang AL
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
Cell metabolism 2023 Nov 7;35(11):1961-1975.e6
A bacteria-derived tetramerized protein ameliorates nonalcoholic steatohepatitis in mice via binding and relocating acetyl-coA carboxylase.
Lin Y, Yang M, Huang L, Yang F, Fan J, Qiang Y, Chang Y, Zhou W, Yan L, Xiong J, Ping J, Chen S, Men D, Li F
Cell reports 2023 Nov 28;42(11):113453
Cell reports 2023 Nov 28;42(11):113453
Acetyl-CoA is a key molecule for nephron progenitor cell pool maintenance.
Diniz F, Ngo NYN, Colon-Leyva M, Edgington-Giordano F, Hilliard S, Zwezdaryk K, Liu J, El-Dahr SS, Tortelote GG
Nature communications 2023 Nov 25;14(1):7733
Nature communications 2023 Nov 25;14(1):7733
Active post-transcriptional regulation and ACLY-mediated acetyl-CoA synthesis as a pivotal target of Shuang-Huang-Sheng-Bai formula for lung adenocarcinoma treatment.
Liu D, Dong C, Wang F, Liu W, Jin X, Qi SL, Liu L, Jin Q, Wang S, Wu J, Wang C, Yang J, Deng H, Cai Y, Yang L, Qin J, Zhang C, Yang X, Wang MS, Yu G, Xue YW, Wang Z, Ge GB, Xu Z, Chen WL
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154732
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 May;113:154732
Acetyl-CoA carboxylase 1 is a suppressor of the adipocyte thermogenic program.
Guilherme A, Rowland LA, Wetoska N, Tsagkaraki E, Santos KB, Bedard AH, Henriques F, Kelly M, Munroe S, Pedersen DJ, Ilkayeva OR, Koves TR, Tauer L, Pan M, Han X, Kim JK, Newgard CB, Muoio DM, Czech MP
Cell reports 2023 May 30;42(5):112488
Cell reports 2023 May 30;42(5):112488
Acetylcarnitine shuttling links mitochondrial metabolism to histone acetylation and lipogenesis.
Izzo LT, Trefely S, Demetriadou C, Drummond JM, Mizukami T, Kuprasertkul N, Farria AT, Nguyen PTT, Murali N, Reich L, Kantner DS, Shaffer J, Affronti H, Carrer A, Andrews A, Capell BC, Snyder NW, Wellen KE
Science advances 2023 May 3;9(18):eadf0115
Science advances 2023 May 3;9(18):eadf0115
Differential Inhibition of Anaplerotic Pyruvate Carboxylation and Glutaminolysis-Fueled Anabolism Underlies Distinct Toxicity of Selenium Agents in Human Lung Cancer.
Fan TW, Winnike J, Al-Attar A, Belshoff AC, Lorkiewicz PK, Tan JL, Wu M, Higashi RM, Lane AN
Metabolites 2023 Jun 21;13(7)
Metabolites 2023 Jun 21;13(7)
TRIM21 attenuates renal carcinoma lipogenesis and malignancy by regulating SREBF1 protein stability.
Chen X, Yong H, Chen M, Deng C, Wang P, Chu S, Li M, Hou P, Zheng J, Li Z, Bai J
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Journal of experimental & clinical cancer research : CR 2023 Jan 25;42(1):34
Bempedoic Acid Unveils Therapeutic Potential in Non-Alcoholic Fatty Liver Disease: Suppression of the Hepatic PXR-SLC13A5/ACLY Signaling Axis.
Sun Q, Guo Y, Hu W, Zhang M, Wang S, Lei Y, Meng H, Li N, Xu P, Li Z, Lin H, Huang F, Qiu Z
Drug metabolism and disposition: the biological fate of chemicals 2023 Dec;51(12):1628-1641
Drug metabolism and disposition: the biological fate of chemicals 2023 Dec;51(12):1628-1641
LncHLEF promotes hepatic lipid synthesis through miR-2188-3p/GATA6 axis and encoding peptides and enhances intramuscular fat deposition via exosome.
Guo Y, Tian W, Wang D, Yang L, Wang Z, Wu X, Zhi Y, Zhang K, Wang Y, Li Z, Jiang R, Sun G, Li G, Tian Y, Wang H, Kang X, Liu X, Li H
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127061
International journal of biological macromolecules 2023 Dec 31;253(Pt 5):127061
Deletion of ACLY Disrupts Histone Acetylation and IL-10 Secretion in Trophoblasts, Which Inhibits M2 Polarization of Macrophages: A Possible Role in Recurrent Spontaneous Abortion.
Chen X, Song QL, Li ZH, Ji R, Wang JY, Ge C, Xiao ZN, Guo DY, Yang J
Oxidative medicine and cellular longevity 2022;2022:5216786
Oxidative medicine and cellular longevity 2022;2022:5216786
Impact of ATP-citrate lyase catalytic activity and serine 455 phosphorylation on histone acetylation and inflammatory responses in human monocytic THP-1 cells.
Dominguez M, Truemper V, Mota AC, Brüne B, Namgaladze D
Frontiers in immunology 2022;13:906127
Frontiers in immunology 2022;13:906127
PRMT5 confers lipid metabolism reprogramming, tumour growth and metastasis depending on the SIRT7-mediated desuccinylation of PRMT5 K387 in tumours.
Yuan HF, Zhao M, Zhao LN, Yun HL, Yang G, Geng Y, Wang YF, Zheng W, Yuan Y, Song TQ, Niu JQ, Zhang XD
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
Acta pharmacologica Sinica 2022 Sep;43(9):2373-2385
PTPRO represses colorectal cancer tumorigenesis and progression by reprogramming fatty acid metabolism.
Dai W, Xiang W, Han L, Yuan Z, Wang R, Ma Y, Yang Y, Cai S, Xu Y, Mo S, Li Q, Cai G
Cancer communications (London, England) 2022 Sep;42(9):848-867
Cancer communications (London, England) 2022 Sep;42(9):848-867
circPRKAA1 activates a Ku80/Ku70/SREBP-1 axis driving de novo fatty acid synthesis in cancer cells.
Li Q, Yao H, Wang Y, Wu Y, Thorne RF, Zhu Y, Wu M, Liu L
Cell reports 2022 Nov 22;41(8):111707
Cell reports 2022 Nov 22;41(8):111707
The enhancer RNA ADCY10P1 is associated with the progression of ovarian cancer.
Mo J, Zhang L, Li H, Duan H, Wang D, Zhao X, Xie Y
Journal of ovarian research 2022 May 14;15(1):61
Journal of ovarian research 2022 May 14;15(1):61
The CBL-LSD1-CXCL8 axis regulates methionine metabolism in glioma.
Chang J, Wang L, Zhou X, Yuan J, Xu W
Cytokine 2022 Mar;151:155789
Cytokine 2022 Mar;151:155789
Albumin knockout mice exhibit reduced plasma free fatty acid concentration and enhanced insulin sensitivity.
Abdollahi A, Dowden BN, Buhman KK, Zembroski AS, Henderson GC
Physiological reports 2022 Mar;10(5):e15161
Physiological reports 2022 Mar;10(5):e15161
Novel phosphanegold(I) thiolate complexes suppress de novo lipid synthesis in human lung cancer.
Luo M, Ma X, Jiang W, Zhang J, Liu W, Wei S, Liu H
European journal of medicinal chemistry 2022 Mar 15;232:114168
European journal of medicinal chemistry 2022 Mar 15;232:114168
Endurance exercise-mediated metabolic reshuffle attenuates high-caloric diet-induced non-alcoholic fatty liver disease.
Cook JJ, Wei M, Segovia B, Cosio-Lima L, Simpson J, Taylor S, Koh Y, Kim S, Lee Y
Annals of hepatology 2022 Jul-Aug;27(4):100709
Annals of hepatology 2022 Jul-Aug;27(4):100709
Quantitative subcellular acyl-CoA analysis reveals distinct nuclear metabolism and isoleucine-dependent histone propionylation.
Trefely S, Huber K, Liu J, Noji M, Stransky S, Singh J, Doan MT, Lovell CD, von Krusenstiern E, Jiang H, Bostwick A, Pepper HL, Izzo L, Zhao S, Xu JP, Bedi KC Jr, Rame JE, Bogner-Strauss JG, Mesaros C, Sidoli S, Wellen KE, Snyder NW
Molecular cell 2022 Jan 20;82(2):447-462.e6
Molecular cell 2022 Jan 20;82(2):447-462.e6
Nanog mediated by FAO/ACLY signaling induces cellular dormancy in colorectal cancer cells.
Zhang M, Peng R, Wang H, Yang Z, Zhang H, Zhang Y, Wang M, Wang H, Lin J, Zhao Q, Liu J
Cell death & disease 2022 Feb 17;13(2):159
Cell death & disease 2022 Feb 17;13(2):159
Glucose-6-phosphate dehydrogenase exerts antistress effects independently of its enzymatic activity.
Jin X, Li X, Li L, Zhong B, Hong Y, Niu J, Li B
The Journal of biological chemistry 2022 Dec;298(12):102587
The Journal of biological chemistry 2022 Dec;298(12):102587
Di-2-ethylhexyl phthalate-induced miR-155-5p promoted lipid metabolism via inhibiting cAMP/PKA signaling pathway in human trophoblastic HTR-8/Svneo cells.
Gu X, Liu H, Luo W, Wang X, Wang H, Li L
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Reproductive toxicology (Elmsford, N.Y.) 2022 Dec;114:22-31
Bempedoic acid, an ATP citrate lyase inhibitor, reduces intimal hyperplasia via activation of AMPKα signaling pathway.
Liu W, Liu M, Xiong H, Xia L, Yang Q, Chen M, Cai Y, Li S
International immunopharmacology 2022 Dec;113(Pt A):109392
International immunopharmacology 2022 Dec;113(Pt A):109392
Hypoxia promotes osteogenesis by facilitating acetyl-CoA-mediated mitochondrial-nuclear communication.
Pouikli A, Maleszewska M, Parekh S, Yang M, Nikopoulou C, Bonfiglio JJ, Mylonas C, Sandoval T, Schumacher AL, Hinze Y, Matic I, Frezza C, Tessarz P
The EMBO journal 2022 Dec 1;41(23):e111239
The EMBO journal 2022 Dec 1;41(23):e111239
Mitofusin 2 Deficiency Causes Pro-Inflammatory Effects in Human Primary Macrophages.
Khodzhaeva V, Schreiber Y, Geisslinger G, Brandes RP, Brüne B, Namgaladze D
Frontiers in immunology 2021;12:723683
Frontiers in immunology 2021;12:723683
Novel SREBP1 inhibitor cinobufotalin suppresses proliferation of hepatocellular carcinoma by targeting lipogenesis.
Meng H, Shen M, Li J, Zhang R, Li X, Zhao L, Huang G, Liu J
European journal of pharmacology 2021 Sep 5;906:174280
European journal of pharmacology 2021 Sep 5;906:174280
Metformin alleviates inflammation through suppressing FASN-dependent palmitoylation of Akt.
Xiong W, Sun KY, Zhu Y, Zhang X, Zhou YH, Zou X
Cell death & disease 2021 Oct 12;12(10):934
Cell death & disease 2021 Oct 12;12(10):934
ER resident protein 44 promotes malignant phenotype in nasopharyngeal carcinoma through the interaction with ATP citrate lyase.
Tian H, Shi S, You B, Zhang Q, Gu M, You Y
Journal of translational medicine 2021 Feb 16;19(1):77
Journal of translational medicine 2021 Feb 16;19(1):77
Nuclear-translocation of ACLY induced by obesity-related factors enhances pyrimidine metabolism through regulating histone acetylation in endometrial cancer.
Dai M, Yang B, Chen J, Liu F, Zhou Y, Zhou Y, Xu Q, Jiang S, Zhao S, Li X, Zhou X, Yang Q, Li J, Wang Y, Zhang Z, Teng Y
Cancer letters 2021 Aug 10;513:36-49
Cancer letters 2021 Aug 10;513:36-49
Control of Adipocyte Thermogenesis and Lipogenesis through β3-Adrenergic and Thyroid Hormone Signal Integration.
Guilherme A, Yenilmez B, Bedard AH, Henriques F, Liu D, Lee A, Goldstein L, Kelly M, Nicoloro SM, Chen M, Weinstein L, Collins S, Czech MP
Cell reports 2020 May 5;31(5):107598
Cell reports 2020 May 5;31(5):107598
Dietary fructose feeds hepatic lipogenesis via microbiota-derived acetate.
Zhao S, Jang C, Liu J, Uehara K, Gilbert M, Izzo L, Zeng X, Trefely S, Fernandez S, Carrer A, Miller KD, Schug ZT, Snyder NW, Gade TP, Titchenell PM, Rabinowitz JD, Wellen KE
Nature 2020 Mar;579(7800):586-591
Nature 2020 Mar;579(7800):586-591
Acetyl-CoA Derived from Hepatic Peroxisomal β-Oxidation Inhibits Autophagy and Promotes Steatosis via mTORC1 Activation.
He A, Chen X, Tan M, Chen Y, Lu D, Zhang X, Dean JM, Razani B, Lodhi IJ
Molecular cell 2020 Jul 2;79(1):30-42.e4
Molecular cell 2020 Jul 2;79(1):30-42.e4
Emodin Induced SREBP1-Dependent and SREBP1-Independent Apoptosis in Hepatocellular Carcinoma Cells.
Yang N, Li C, Li H, Liu M, Cai X, Cao F, Feng Y, Li M, Wang X
Frontiers in pharmacology 2019;10:709
Frontiers in pharmacology 2019;10:709
ACLY facilitates colon cancer cell metastasis by CTNNB1.
Wen J, Min X, Shen M, Hua Q, Han Y, Zhao L, Liu L, Huang G, Liu J, Zhao X
Journal of experimental & clinical cancer research : CR 2019 Sep 12;38(1):401
Journal of experimental & clinical cancer research : CR 2019 Sep 12;38(1):401
Lin28 enhances de novo fatty acid synthesis to promote cancer progression via SREBP-1.
Zhang Y, Li C, Hu C, Wu Q, Cai Y, Xing S, Lu H, Wang L, Huang D, Sun L, Li T, He X, Zhong X, Wang J, Gao P, Smith ZJ, Jia W, Zhang H
EMBO reports 2019 Oct 4;20(10):e48115
EMBO reports 2019 Oct 4;20(10):e48115
Adipocyte ACLY Facilitates Dietary Carbohydrate Handling to Maintain Metabolic Homeostasis in Females.
Fernandez S, Viola JM, Torres A, Wallace M, Trefely S, Zhao S, Affronti HC, Gengatharan JM, Guertin DA, Snyder NW, Metallo CM, Wellen KE
Cell reports 2019 May 28;27(9):2772-2784.e6
Cell reports 2019 May 28;27(9):2772-2784.e6
Subcellular metabolic pathway kinetics are revealed by correcting for artifactual post harvest metabolism.
Trefely S, Liu J, Huber K, Doan MT, Jiang H, Singh J, von Krusenstiern E, Bostwick A, Xu P, Bogner-Strauss JG, Wellen KE, Snyder NW
Molecular metabolism 2019 Dec;30:61-71
Molecular metabolism 2019 Dec;30:61-71
Polarization of Human Macrophages by Interleukin-4 Does Not Require ATP-Citrate Lyase.
Namgaladze D, Zukunft S, Schnütgen F, Kurrle N, Fleming I, Fuhrmann D, Brüne B
Frontiers in immunology 2018;9:2858
Frontiers in immunology 2018;9:2858
DJ-1 Deficiency Protects Hepatic Steatosis by Enhancing Fatty Acid Oxidation in Mice.
Xu M, Wu H, Li M, Wen Y, Yu C, Xia L, Xia Q, Kong X
International journal of biological sciences 2018;14(13):1892-1900
International journal of biological sciences 2018;14(13):1892-1900
Acetate Production from Glucose and Coupling to Mitochondrial Metabolism in Mammals.
Liu X, Cooper DE, Cluntun AA, Warmoes MO, Zhao S, Reid MA, Liu J, Lund PJ, Lopes M, Garcia BA, Wellen KE, Kirsch DG, Locasale JW
Cell 2018 Oct 4;175(2):502-513.e13
Cell 2018 Oct 4;175(2):502-513.e13
Fatty acid synthesis is critical for stem cell pluripotency via promoting mitochondrial fission.
Wang L, Zhang T, Wang L, Cai Y, Zhong X, He X, Hu L, Tian S, Wu M, Hui L, Zhang H, Gao P
The EMBO journal 2017 May 15;36(10):1330-1347
The EMBO journal 2017 May 15;36(10):1330-1347
Acetyl-CoA synthetase regulates histone acetylation and hippocampal memory.
Mews P, Donahue G, Drake AM, Luczak V, Abel T, Berger SL
Nature 2017 Jun 15;546(7658):381-386
Nature 2017 Jun 15;546(7658):381-386
Nuclear Acetyl-CoA Production by ACLY Promotes Homologous Recombination.
Sivanand S, Rhoades S, Jiang Q, Lee JV, Benci J, Zhang J, Yuan S, Viney I, Zhao S, Carrer A, Bennett MJ, Minn AJ, Weljie AM, Greenberg RA, Wellen KE
Molecular cell 2017 Jul 20;67(2):252-265.e6
Molecular cell 2017 Jul 20;67(2):252-265.e6
ACSS2-mediated acetyl-CoA synthesis from acetate is necessary for human cytomegalovirus infection.
Vysochan A, Sengupta A, Weljie AM, Alwine JC, Yu Y
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 21;114(8):E1528-E1535
Proceedings of the National Academy of Sciences of the United States of America 2017 Feb 21;114(8):E1528-E1535
The microRNA-182-PDK4 axis regulates lung tumorigenesis by modulating pyruvate dehydrogenase and lipogenesis.
Li G, Li M, Hu J, Lei R, Xiong H, Ji H, Yin H, Wei Q, Hu G
Oncogene 2017 Feb 16;36(7):989-998
Oncogene 2017 Feb 16;36(7):989-998
CDC5L drives FAH expression to promote metabolic reprogramming in melanoma.
Gu Z, Zhang H, Li Y, Shen S, Yin X, Zhang W, Cheng R, Zhang Y, Zhang X, Chen H, Huang B, Cao Y
Oncotarget 2017 Dec 26;8(69):114328-114343
Oncotarget 2017 Dec 26;8(69):114328-114343
Acetyl-coenzyme A carboxylase alpha promotion of glucose-mediated fatty acid synthesis enhances survival of hepatocellular carcinoma in mice and patients.
Wang MD, Wu H, Fu GB, Zhang HL, Zhou X, Tang L, Dong LW, Qin CJ, Huang S, Zhao LH, Zeng M, Wu MC, Yan HX, Wang HY
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Hepatology (Baltimore, Md.) 2016 Apr;63(4):1272-86
Knockdown of PKM2 Suppresses Tumor Growth and Invasion in Lung Adenocarcinoma.
Sun H, Zhu A, Zhang L, Zhang J, Zhong Z, Wang F
International journal of molecular sciences 2015 Oct 15;16(10):24574-87
International journal of molecular sciences 2015 Oct 15;16(10):24574-87
Mutations in CIC and IDH1 cooperatively regulate 2-hydroxyglutarate levels and cell clonogenicity.
Chittaranjan S, Chan S, Yang C, Yang KC, Chen V, Moradian A, Firme M, Song J, Go NE, Blough MD, Chan JA, Cairncross JG, Gorski SM, Morin GB, Yip S, Marra MA
Oncotarget 2014 Sep 15;5(17):7960-79
Oncotarget 2014 Sep 15;5(17):7960-79
Human cytomegalovirus infection induces adipocyte-like lipogenesis through activation of sterol regulatory element binding protein 1.
Yu Y, Maguire TG, Alwine JC
Journal of virology 2012 Mar;86(6):2942-9
Journal of virology 2012 Mar;86(6):2942-9
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- K-562 cells were subjected to SDS PAGE followed by western blot with 15421-1-AP(ACLY antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using ACLY antibody 15421-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
