Antibody data
- Antibody Data
- Antigen structure
- References [52]
- Comments [0]
- Validations
- Western blot [1]
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Validation data
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- Product number
- 16456-1-AP - Provider product page

- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#16456-1-AP, RRID:AB_10733226
- Product name
- Claudin 3 antibody
- Antibody type
- Polyclonal
- Description
- Claudin 3 antibody (Cat. #16456-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IHC, IP,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references The Protective Effects and Underlying Mechanisms of Taraxacum kok-saghyz Polysaccharides Against Intestinal Dysbiosis-Induced Mastitis Were Elucidated Using a Murine Model of the "Gut-Mammary" Axis.
Lycium Barbarum Polysaccharide Attenuates Staphylococcus aureus-Induced Mastitis via the Gut Microbiota-Derived Indole-3-Propionic Acid/AhR-IL-22-STAT3 Axis.
Physical crowding in 3D niche regulates neural stem cell differentiation via Cx43-mediated gap junction communication.
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Insight into perfluorooctanoic acid-induced impairment of mouse embryo implantation via single-cell RNA-seq.
Fisetin alleviates Salmonella typhimurium-induced colitis through the TLR2/TLR4-NF-κB pathway, regulating microbiota, and repressing intracellular bacterial proliferation by focal adhesion kinase.
Phillyrin ameliorates DSS-induced colitis in mice via modulating the gut microbiota and inhibiting the NF-κB/MLCK pathway.
Swertiamarin relieves radiation-induced intestinal injury by limiting DNA damage.
Overexpression of the Mas1 gene mitigated LPS-induced inflammatory injury in mammary epithelial cells by inhibiting the NF-κB/MAPKs signaling pathways.
Zinc oxide nanoparticles disrupt the mammary epithelial barrier via Z-DNA binding protein 1-triggered PANoptosis.
MTCH2 promotes the malignant progression of ovarian cancer through the upregulation of AIMP2 expression levels, mitochondrial dysfunction and by mediating energy metabolism.
Gut Lactococcus garvieae promotes protective immunity to foodborne Clostridium perfringens infection.
Morin alleviates DSS-induced ulcerative colitis in mice via inhibition of inflammation and modulation of intestinal microbiota.
Increased SPARC in brain microvessels of ob/ob mice accelerates molecular transport into the brain accompany with albumin.
Puerarin Delays Mammary Gland Aging by Regulating Gut Microbiota and Inhibiting the p38MAPK Signaling Pathway.
Longitudinal gut fungal alterations and potential fungal biomarkers for the progression of primary liver disease.
An Isofibrous Diet with Fiber Konjac Glucomannan Ameliorates Salmonella typhimurium-Induced Colonic Injury by Regulating TLR2-NF-κB Signaling and Intestinal Microbiota in Mice.
Expression Patterns of Grainyhead-Like 2 and Ovo-Like 2 in Mouse Mammary Gland Development During Pregnancy, Lactation, and Weaning.
Platelet-rich plasma-derived exosomes promote blood-spinal cord barrier repair and attenuate neuroinflammation after spinal cord injury.
Gubra Amylin-NASH Diet Induced Nonalcoholic Fatty Liver Disease Associated with Histological Damage, Oxidative Stress, Immune Disorders, Gut Microbiota, and Its Metabolic Dysbiosis in Colon.
Live and pasteurized Akkermansia muciniphila decrease susceptibility to Salmonella Typhimurium infection in mice.
The coexistence of aflatoxin M1 and ochratoxin A induced intestinal barrier disruption via the regulation of key differentially expressed microRNAs and long non-coding RNAs in BALB/c mice.
Environmental cadmium exposure facilitates mammary tumorigenesis via reprogramming gut microbiota-mediated glutamine metabolism in MMTV-Erbb2 mice.
Rat tight junction proteins are disrupted after subchronic exposure to okadaic acid.
A high-sucrose diet causes microbiota composition shift and promotes the susceptibility of mice to Salmonella Typhimurium infection.
Dendritic cell-derived exosomal miR-3064-5p inhibits SIRT6/PCSK9 to protect the blood-brain barrier after subarachnoid hemorrhage.
Open hepatic artery flow with portal vein clamping protects against bile duct injury compared to pringles maneuver.
Inhibition of S100A9 alleviates neurogenic pulmonary edema after subarachnoid hemorrhage.
Dietary pectin attenuates Salmonella typhimurium-induced colitis by modulating the TLR2-NF-κB pathway and intestinal microbiota in mice.
A high-concentrate diet induces colonic inflammation and barrier damage in Hu sheep.
Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
Zhibai Dihuang Pill Alleviates Ureaplasma urealyticum-Induced Spermatogenic Failure and Testicular Dysfunction via MAPK Signaling Pathway.
Effects of Electroacupuncture at Different Acupoints on Functional Dyspepsia Rats.
Phytic Acid Improves Hepatic Steatosis, Inflammation, and Oxidative Stress in High-Fat Diet (HFD)-Fed Mice by Modulating the Gut-Liver Axis.
Sanhuang Xiexin decoction ameliorates DSS-induced colitis in mice by regulating intestinal inflammation, intestinal barrier, and intestinal flora.
JAC4 Protects from X-ray Radiation-Induced Intestinal Injury by JWA-Mediated Anti-Oxidation/Inflammation Signaling.
Decreased ZO1 expression causes loss of time-dependent tight junction function in the liver of ob/ob mice.
Integrated Profiles of Transcriptome and mRNA m6A Modification Reveal the Intestinal Cytotoxicity of Aflatoxin B1 on HCT116 Cells.
Curcumin Alleviates Dextran Sulfate Sodium-Induced Colitis in Mice Through Regulating Gut Microbiota.
BMSCs Regulate Astrocytes through TSG-6 to Protect the Blood-Brain Barrier after Subarachnoid Hemorrhage.
Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice.
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Immune infiltration profiling in gastric cancer and their clinical implications.
Whole transcriptome-based ceRNA network analysis revealed ochratoxin A-induced compromised intestinal tight junction proteins through WNT/Ca(2+) signaling pathway.
Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.
Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts.
Altered protein S-glutathionylation depicts redox imbalance triggered by transition metal oxide nanoparticles in a breastfeeding system.
Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.
Tandem mass tag (TMT) proteomic analysis of fetal lungs revealed differential expression of tight junction proteins in a rat model of congenital diaphragmatic hernia.
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Translocation of transition metal oxide nanoparticles to breast milk and offspring: The necessity of bridging mother-offspring-integration toxicological assessments.
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.
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Open hepatic artery flow with portal vein clamping protects against bile duct injury compared to pringles maneuver.
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Benzo[a]pyrene induces epithelial tight junction disruption and apoptosis via inhibiting the initiation of autophagy in intestinal porcine epithelial cells.
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Chemico-biological interactions 2023 Apr 1;374:110386
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Journal of agricultural and food chemistry 2022 Sep 14;70(36):11401-11411
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Journal of ethnopharmacology 2022 Oct 28;297:115537
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Antioxidants (Basel, Switzerland) 2022 May 27;11(6)
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Molecular biology reports 2022 Dec;49(12):11881-11890
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Molecular nutrition & food research 2022 Apr;66(8):e2100943
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Mediators of inflammation 2021;2021:5522291
Laminin alpha-3 and thrombospondin-1 differently regulate the survival and differentiation of hepatocytes and hepatic stem cells from neonatal mice.
Zhang S, Sharaf Eldin HE, Gu WL, Li TS
American journal of translational research 2021;13(11):12684-12693
American journal of translational research 2021;13(11):12684-12693
Tumor Necrosis Factor-stimulated Gene-6 (TSG-6) Secreted by BMSCs Regulates Activated Astrocytes by Inhibiting NF-κB Signaling Pathway to Ameliorate Blood Brain Barrier Damage After Intracerebral Hemorrhage.
Tang B, Song M, Xie X, Le D, Tu Q, Wu X, Chen M
Neurochemical research 2021 Sep;46(9):2387-2402
Neurochemical research 2021 Sep;46(9):2387-2402
Immune infiltration profiling in gastric cancer and their clinical implications.
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Cancer science 2021 Sep;112(9):3569-3584
Cancer science 2021 Sep;112(9):3569-3584
Whole transcriptome-based ceRNA network analysis revealed ochratoxin A-induced compromised intestinal tight junction proteins through WNT/Ca(2+) signaling pathway.
Yang X, Gao Y, Huang S, Su C, Wang J, Zheng N
Ecotoxicology and environmental safety 2021 Nov;224:112637
Ecotoxicology and environmental safety 2021 Nov;224:112637
Expression of Grainyhead-like 2 in the Process of Ductal Development of Mouse Mammary Gland.
Matsuoka S, Suzuki H, Kato C, Kamikawa-Tokai M, Kamikawa A, Okamatsu-Ogura Y, Kimura K
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2021 Jun;69(6):373-388
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society 2021 Jun;69(6):373-388
Advanced maternal age causes premature placental senescence and malformation via dysregulated α-Klotho expression in trophoblasts.
Chen Z, Xiong L, Jin H, Yu J, Li X, Fu H, Wen L, Qi H, Tong C, Saffery R, Kilby MD, Baker PN
Aging cell 2021 Jul;20(7):e13417
Aging cell 2021 Jul;20(7):e13417
Altered protein S-glutathionylation depicts redox imbalance triggered by transition metal oxide nanoparticles in a breastfeeding system.
Cai J, Zang X, Wu Z, Liu J, Wang D
NanoImpact 2021 Apr;22:100305
NanoImpact 2021 Apr;22:100305
Dual effects of JNK activation in blood-milk barrier damage induced by zinc oxide nanoparticles.
Wu J, Lai X, Cui G, Chen Q, Liu J, Kang Y, Zhang Y, Feng X, Hu C, Shao L
Journal of hazardous materials 2020 Nov 15;399:122809
Journal of hazardous materials 2020 Nov 15;399:122809
Tandem mass tag (TMT) proteomic analysis of fetal lungs revealed differential expression of tight junction proteins in a rat model of congenital diaphragmatic hernia.
Li X, Liu H, Yu W, Liu X, Liu C
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109621
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Jan;121:109621
Responses of intestinal morphology and function in offspring to heat stress in primiparous sows during late gestation.
Guo H, He J, Yang X, Zheng W, Yao W
Journal of thermal biology 2020 Apr;89:102539
Journal of thermal biology 2020 Apr;89:102539
Translocation of transition metal oxide nanoparticles to breast milk and offspring: The necessity of bridging mother-offspring-integration toxicological assessments.
Cai J, Zang X, Wu Z, Liu J, Wang D
Environment international 2019 Dec;133(Pt A):105153
Environment international 2019 Dec;133(Pt A):105153
Deficiency in intestinal epithelial O-GlcNAcylation predisposes to gut inflammation.
Zhao M, Xiong X, Ren K, Xu B, Cheng M, Sahu C, Wu K, Nie Y, Huang Z, Blumberg RS, Han X, Ruan HB
EMBO molecular medicine 2018 Aug;10(8)
EMBO molecular medicine 2018 Aug;10(8)
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image

- Experimental details
- The Claudin 3 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human Claudin 3. This antibody recognizes human,mouse,rat antigen. The Claudin 3 antibody has been validated for the following applications: ELISA, WB analysis.