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- References [21]
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- Product number
- 17895-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#17895-1-AP, RRID:AB_2065351
- Product name
- BHLHE40 antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated BHLHE40 antibody (Cat. #17895-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Digoxin targets BHLHE40 to inhibit epithelial-mesenchymal transition in cervical cancer cells via downregulation of ANGPTL3.
BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation.
Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation.
BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophages.
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction.
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11.
Single cell RNA-sequencing reveals BHLHE40 and NDRG1 as key regulatory molecules modulating the trophoblastic senescence in preeclampsia.
Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer.
Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties.
Long non-coding RNA NEAT1 induced by BHLHE40 activates Wnt/β-catenin signaling and potentiates colorectal cancer progression.
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
The role of BHLHE40 in clinical features and prognosis value of PDAC by comprehensive analysis and in vitro validation.
The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis.
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10.
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue.
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.
17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression.
LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.
Loss of circadian protein TIMELESS accelerates the progression of cellular senescence.
Li C, Luo P, Tang L, Yang Y, Rao L, Zhong L
Journal of natural medicines 2026 Jan;80(1):38-53
Journal of natural medicines 2026 Jan;80(1):38-53
BHLHE40 Cooperates with GATA2/3 to Control Human Syncytiotrophoblast Lineage Differentiation.
Peng L, Zhao W, Xu C, Li Y, Guo J, Zhou T, Chiu P, Wu H, Wu Q, Wei Y, Gao S, Du M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e07642
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(44):e07642
Comprehensive Multimodal Profiling of Atherosclerosis Reveals Bhlhe40 as a Potential Regulator of Vascular Smooth Muscle Cell Phenotypic Modulation.
Ibikunle CO, Xue C, Kim E, Yan H, Coronel J, Zhu LY, Cui J, Chung A, Bauer RC, Sachs N, Maegdefessel L, Li M, Tall AR, Bashore AC, Reilly MP
bioRxiv : the preprint server for biology 2025 May 23;
bioRxiv : the preprint server for biology 2025 May 23;
BHLHE40 contributes to allergic asthma progression in mice through NRTN downregulation in macrophages.
Dai B, Chen L, Li X, Zhou Q, Zhang Q, Han L, Shen W, Chang Q, Zhao Y, Liu S, Shan L
Communications biology 2025 Jun 4;8(1):863
Communications biology 2025 Jun 4;8(1):863
Icaritin induces paraptosis in hepatocellular carcinoma cells by targeting BHLHE40 via endoplasmic reticulum stress and mitochondrial dysfunction.
Wei W, Wang H, Fu L, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156870
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jul 25;143:156870
Endothelial mechanosensitive transcription factor BHLHE40 induced by Piezo1 suppresses endothelial ferroptosis and inflammation via SLC7A11.
Miao S, Dai X, Li X, Chen Z, Wang Y, Ye T, Ying Y, Yu Y, Wu A, Song H, Teng P, Ma L, Zheng Q
Cell death discovery 2025 Dec 10;12(1):47
Cell death discovery 2025 Dec 10;12(1):47
Single cell RNA-sequencing reveals BHLHE40 and NDRG1 as key regulatory molecules modulating the trophoblastic senescence in preeclampsia.
Zhang Y, Chu J, Yu Z, Gong Y
Placenta 2025 Aug;168:74-87
Placenta 2025 Aug;168:74-87
Single-Cell and Spatial Transcriptome Profiling Identifies the Transcription Factor BHLHE40 as a Driver of EMT in Metastatic Colorectal Cancer.
Yang S, Zhang D, Sun Q, Nie H, Zhang Y, Wang X, Huang Y, Sun Y
Cancer research 2024 Jul 2;84(13):2202-2217
Cancer research 2024 Jul 2;84(13):2202-2217
Discovery of Transcription Factors Involved in the Maintenance of Resident Vascular Endothelial Stem Cell Properties.
Konishi H, Rahmawati FN, Okamoto N, Akuta K, Inukai K, Jia W, Muramatsu F, Takakura N
Molecular and cellular biology 2024 Jan;44(1):17-26
Molecular and cellular biology 2024 Jan;44(1):17-26
Long non-coding RNA NEAT1 induced by BHLHE40 activates Wnt/β-catenin signaling and potentiates colorectal cancer progression.
Ji A, Li H, Fu X, Zhang Y, Liu Y
Cell division 2024 Aug 4;19(1):25
Cell division 2024 Aug 4;19(1):25
DEC1 is involved in circadian rhythm disruption-exacerbated pulmonary fibrosis.
Chen SJ, Yu F, Feng X, Li Q, Jiang YH, Zhao LQ, Cheng PP, Wang M, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ye H, Ma WL
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
Cell communication and signaling : CCS 2024 Apr 26;22(1):245
The role of BHLHE40 in clinical features and prognosis value of PDAC by comprehensive analysis and in vitro validation.
Liu C, Du J, Zheng J, Zhang R, Zhu J, Xing B, Dong L, Zhou Q, Yao X, Gao S, Wang Y, Ren Y, Zhou X
Frontiers in oncology 2023;13:1151321
Frontiers in oncology 2023;13:1151321
The PRMT6/PARP1/CRL4B Complex Regulates the Circadian Clock and Promotes Breast Tumorigenesis.
Yang T, Huang W, Ma T, Yin X, Zhang J, Huo M, Hu T, Gao T, Liu W, Zhang D, Yu H, Teng X, Zhang M, Qin H, Yang Y, Yuan B, Wang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2202737
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 May;10(14):e2202737
Long noncoding RNA SNHG1 alleviates high glucose-induced vascular smooth muscle cells calcification/senescence by post-transcriptionally regulating Bhlhe40 and autophagy via Atg10.
Li S, Ni Y, Li C, Xiang Q, Zhao Y, Xu H, Huang W, Wang Y, Wang Y, Zhan J, Liu Y
Journal of physiology and biochemistry 2023 Feb;79(1):83-105
Journal of physiology and biochemistry 2023 Feb;79(1):83-105
BMAL1/p53 mediating bronchial epithelial cell autophagy contributes to PM2.5-aggravated asthma.
Chen SJ, Huang Y, Yu F, Feng X, Zheng YY, Li Q, Niu Q, Jiang YH, Zhao LQ, Wang M, Cheng PP, Song LJ, Liang LM, He XL, Xiong L, Xiang F, Wang X, Ma WL, Ye H
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
Cell communication and signaling : CCS 2023 Feb 20;21(1):39
The miR-23-27-24 clusters drive lipid-associated macrophage proliferation in obese adipose tissue.
Sprenkle NT, Winn NC, Bunn KE, Zhao Y, Park DJ, Giese BG, Karijolich JJ, Ansel KM, Serezani CH, Hasty AH, Pua HH
Cell reports 2023 Aug 29;42(8):112928
Cell reports 2023 Aug 29;42(8):112928
Cardiac-specific knockdown of Bhlhe40 attenuates angiotensin II (Ang II)-Induced atrial fibrillation in mice.
Ren KW, Yu XH, Gu YH, Xie X, Wang Y, Wang SH, Li HH, Bi HL
Frontiers in cardiovascular medicine 2022;9:957903
Frontiers in cardiovascular medicine 2022;9:957903
Bhlhe40/Sirt1 Axis-Regulated Mitophagy Is Implicated in All-Trans Retinoic Acid-Induced Spina Bifida Aperta.
Zhao L, Liu D, Ma W, Gu H, Wei X, Luo W, Yuan Z
Frontiers in cell and developmental biology 2021;9:644346
Frontiers in cell and developmental biology 2021;9:644346
17β-Estradiol Inhibits Proliferation and Oxidative Stress in Vascular Smooth Muscle Cells by Upregulating BHLHE40 Expression.
Feng DD, Zheng B, Yu J, Zhang ML, Ma Y, Hao X, Wen JK, Zhang XH
Frontiers in cardiovascular medicine 2021;8:768662
Frontiers in cardiovascular medicine 2021;8:768662
LncRNA-ES3 inhibition by Bhlhe40 is involved in high glucose-induced calcification/senescence of vascular smooth muscle cells.
Zhong JY, Cui XJ, Zhan JK, Wang YJ, Li S, Lin X, Xiang QY, Ni YQ, Liu L, Liu YS
Annals of the New York Academy of Sciences 2020 Aug;1474(1):61-72
Annals of the New York Academy of Sciences 2020 Aug;1474(1):61-72
Loss of circadian protein TIMELESS accelerates the progression of cellular senescence.
Shen X, Li M, Mao Z, Yu W
Biochemical and biophysical research communications 2018 Sep 18;503(4):2784-2791
Biochemical and biophysical research communications 2018 Sep 18;503(4):2784-2791
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The BHLHE40 antibody from Proteintech is a rabbit polyclonal antibody to a recombinant protein of human BHLHE40. This antibody recognizes human,mouse,rat antigen. The BHLHE40 antibody has been validated for the following applications: ELISA, WB analysis.
