17978-1-AP

antibody from Proteintech Group

Targeting: CNR1 CANN6, CB-R, CB1, CB1A, CB1K5, CNR

Provider product page for 17978-1-AP

Western blot

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Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [36]
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Validations
Western blot [1]

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Product number: 17978-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#17978-1-AP, RRID:AB_10859098
Product name: Cannabinoid receptor 1 antibody
Antibody type: Polyclonal
Description: Cannabinoid receptor 1 antibody (Cat. #17978-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

CNR1 protein structure - 17978-1-AP shown in red.

Submitted references The role of the kynurenine pathway in conditioned place aversion induced by synthetic cannabinoid CP-55940.

Cong J, Zhang H, Li N, Yang J, Liu M, Ma Q, Zhang C, Yan G
Behavioral and brain functions : BBF 2026 Mar 17;22(1)

Exposure to Green Light-emitting Diodes Alleviates Endometriosis-associated Pain in Mice with Induced Deep Endometriosis.

Dong J, Liu X, Guo SW
Reproductive sciences (Thousand Oaks, Calif.) 2026 Apr;33(4):729-741

Integrated multi-omic profiling uncovers endocannabinoid system as a driver of nerve agent-induced cognitive dysfunction in guinea pigs.

Jin Q, Lin Y, Wei Y, Liu Z, Cao M, Chen X, Li L
Archives of toxicology 2025 Oct;99(10):4081-4103

Epigenetic regulation by WTAPP1 promotes trophoblast dysfunction in gestational diabetes via CNR1/NF-κB activation.

Yang N, Li Y, Zhang J, Gao X, Zhang P, Li W
European journal of medical research 2025 Oct 15;30(1):975

13-Docosenamide Enhances Oligodendrocyte Precursor Cell Differentiation via USP33-Mediated Deubiquitination of CNR1 in Chronic Cerebral Hypoperfusion.

Xu Y, Tan Y, Zhang Z, Chen D, Zhou C, Sun L, Xia S, Bao X, Yang H, Xu Y
Neuroscience bulletin 2025 Nov;41(11):1939-1956

Dopamine D2S/D2L Receptor Regulation of Alcohol-Induced Reward and Signalling.

Tayyab M, Sasaoka T, Abe M, Saito N, Sakimura K, Ninan A, Wang Y
Addiction biology 2025 Nov;30(11):e70093

Δ(9)-tetrahydrocannabinol induces blood-brain barrier disruption: Involving the activation of CB1R and oxidative stress.

Zhang Q, Huang W, Li T, Wang X, Lai X, Hu W, Li Z, Zeng X, Huang J, Zhang R
Neuropharmacology 2025 Jun 1;270:110366

DR8 (DHNNPQIR), a rapeseed-derived peptide, mitigates fibrosis and muscle atrophy in chronic kidney disease by targeting CNR1-ERK/ELK-1 signaling.

Zhang W, Zuo Y, Xu D, Lin Y, Zang Y, Chen R, Chen M, Su Z
Peptides 2025 Dec;194:171456

Differential regulation of pruritic sensation and emotion by cannabinoid type 1 receptors on mPFC glutamatergic and GABAergic neurons.

Zhanmu OY, Yang Y, Feng B, Wang HY, Li H, Zhou HJ, Ge WQ, Wan KX, Wang SX, Zhang KL, Zhang H, Pei L, Pan HL, Tian Q, Li M
Acta pharmacologica Sinica 2025 Apr;46(4):904-921

Deletion of Fgf14 confers resilience to basal and stress-induced depressive-like behavior and reduces anxiety in mice.

Montarolo F, Rominto AM, Berrino L, Bertolotto A, Laezza F, Tempia F, Hoxha E
Translational psychiatry 2025 Apr 9;15(1):136

Cannabinoid receptor 1 positive allosteric modulator ZCZ011 shows differential effects on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice.

Yadav-Samudrala BJ, Dodson H, Ramineni S, Kim E, Poklis JL, Lu D, Ignatowska-Jankowska BM, Lichtman AH, Fitting S
PloS one 2024;19(6):e0305868

Effects of acute cannabidiol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice.

Yadav-Samudrala BJ, Gorman BL, Barmada KM, Ravula HP, Huguely CJ, Wallace ED, Peace MR, Poklis JL, Jiang W, Fitting S
Frontiers in neuroscience 2024;18:1358555

Cannabinoid receptor 2 agonist AM1241 alleviates epileptic seizures and epilepsy-associated depression via inhibiting neuroinflammation in a pilocarpine-induced chronic epilepsy mouse model.

Cai Y, Tong F, Li K, Wang Q, Ding J, Wang X
Molecular and cellular neurosciences 2024 Sep;130:103958

Divergent input patterns to the central lateral amygdala play a duet in fear memory formation.

Gao JH, Liu YY, Xu HX, Wu K, Zhang LL, Cheng P, Peng XH, Cao JL, Hua R, Zhang YM
iScience 2024 Oct 18;27(10):110886

Inhibiting the CB1 receptor in CIH-induced animal model alleviates colon injury.

Wang PP, Cheng XQ, Dou ZJ, Fan YQ, Chen J, Zhao L, Han JX, Lin XW, Wang B
Applied microbiology and biotechnology 2024 Jun 18;108(1):380

Effects of acute Δ(9)-tetrahydrocannabinol on behavior and the endocannabinoid system in HIV-1 Tat transgenic female and male mice.

Yadav-Samudrala BJ, Gorman BL, Dodson H, Ramineni S, Wallace ED, Peace MR, Poklis JL, Jiang W, Fitting S
Brain research 2024 Jan 1;1822:148638

Acute Effects of Monoacylglycerol Lipase Inhibitor ABX1431 on Neuronal Hyperexcitability, Nociception, Locomotion, and the Endocannabinoid System in HIV-1 Tat Male Mice.

Yadav-Samudrala BJ, Ravula HP, Barmada KM, Dodson H, Poklis JL, Ignatowska-Jankowska BM, Lichtman AH, Reissner KJ, Fitting S
Cannabis and cannabinoid research 2024 Dec;9(6):1500-1513

Studies of Anticancer Activities In Vitro and In Vivo for Butyltin(IV)-Iridium(III) Imidazole-Phenanthroline Complexes with Aggregation-Induced Emission Properties.

Sun Y, Liu J, Li Q, Zhang X, Cao Z, Bu L, Cao S, Liu X, Yuan XA, Liu Z
Inorganic chemistry 2024 Aug 5;63(31):14641-14655

Role of gut microbiota in Crohn's disease pathogenesis: Insights from fecal microbiota transplantation in mouse model.

Wu Q, Yuan LW, Yang LC, Zhang YW, Yao HC, Peng LX, Yao BJ, Jiang ZX
World journal of gastroenterology 2024 Aug 21;30(31):3689-3704

Outcomes of early social experiences on glucocorticoid and endocannabinoid systems in the prefrontal cortex of male and female adolescent rats.

Rullo L, Losapio LM, Morosini C, Mottarlini F, Schiavi S, Buzzelli V, Ascone F, Ciccocioppo R, Fattore L, Caffino L, Fumagalli F, Romualdi P, Trezza V, Candeletti S
Frontiers in cellular neuroscience 2023;17:1270195

N-linoleyltyrosine resisted the growth of non-small cell lung cancer cells via the regulation of CB(1) and CB(2) involvement of PI3K and ERK pathways.

Hu Y, Zhao Z, Liu YT, Xu ZC, Li JY, Yang ZY, Rui-Wang, Yang YQ, Zhang JH, Qiu SY, He T, Wu YY, Liu S
Frontiers in pharmacology 2023;14:1164367

Reward enhances resilience to chronic social defeat stress in mice: Neural ECs and mGluR5 mechanism via neuroprotection in VTA and DRN.

Shi P, Hu L, Ren H, Dai Q
Frontiers in psychiatry 2023;14:1084367

The neonatal southern white rhinoceros ovary contains oogonia in germ cell nests.

Appeltant R, Hermes R, Holtze S, Modina SC, Galli C, Bjarkadottir BD, Adeniran BV, Wei X, Swegen A, Hildebrandt TB, Williams SA
Communications biology 2023 Oct 17;6(1):1049

Electroacupuncture repairs intestinal barrier by upregulating CB1 through gut microbiota in DSS-induced acute colitis.

Yang J, Wang L, Mei M, Guo J, Yang X, Liu S
Chinese medicine 2023 Mar 10;18(1):24

Cisplatin-Induced Anorexia and Pica Behavior in Rats Enhanced by Chronic Stress Pretreatment.

Guo Z, Duan J, Chen Y, Cai W, Yang C, Yang Z, Liu X, Xu F
Frontiers in pharmacology 2022;13:913124

Endocannabinoid signalling/cannabinoid receptor 2 is involved in icariin-mediated protective effects against bleomycin-induced pulmonary fibrosis.

Du W, Zhang T, Yang F, Gul A, Tang Z, Zhang H, Jiang S, Wang S, Dong J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Aug;103:154187

Cardiac sudden death in a young cannabis user.

Kasuda S, Kondo T, Terazawa I, Morimoto M, Yuui K, Kudo R
Legal medicine (Tokyo, Japan) 2021 Nov;53:101955

L-Theanine regulates glutamine metabolism and immune function by binding to cannabinoid receptor 1.

Liu A, Lin L, Xu W, Gong Z, Liu Z, Xiao W
Food & function 2021 Jul 5;12(13):5755-5769

N‑linoleyltyrosine protects PC12 cells against oxidative damage via autophagy: Possible involvement of CB1 receptor regulation.

Liu X, Wu Y, Zhou D, Xie Y, Zhou Y, Lu Y, Yang R, Liu S
International journal of molecular medicine 2020 Nov;46(5):1827-1837

A combination of dietary fat intake and nicotine exposure enhances CB1 endocannabinoid receptor expression in hypothalamic nuclei in male mice.

Guo T, Tanaka T, Matsumoto M, Kaneko K, Unzai T, Ogino Y, Aotani D, Kusakabe T, Iwakura H, Miyazawa T, Sawamoto K, Minokoshi Y, Masuzaki H, Inagaki N, Nakao K
Neuroscience letters 2020 Jan 1;714:134550

Dietary intake of polyunsaturated fatty acids alleviates cognition deficits and depression-like behaviour via cannabinoid system in sleep deprivation rats.

Wang T, Niu K, Fan A, Bi N, Tao H, Chen XT, Wang HL
Behavioural brain research 2020 Apr 20;384:112545

Trans-cinnamaldehyde shows anti-depression effect in the forced swimming test and possible involvement of the endocannabinoid system.

Lin J, Song Z, Chen X, Zhao R, Chen J, Chen H, Yang X, Wu Z
Biochemical and biophysical research communications 2019 Oct 15;518(2):351-356

Indoxyl sulfate upregulates the cannabinoid type 1 receptor gene via an ATF3/c-Jun complex-mediated signaling pathway in the model of uremic cardiomyopathy.

Hsu YJ, Hsu SC, Chang YL, Huang SM, Shih CC, Tsai CS, Lin CY
International journal of cardiology 2018 Feb 1;252:128-135

BDNF overexpression prevents cognitive deficit elicited by adolescent cannabis exposure and host susceptibility interaction.

Segal-Gavish H, Gazit N, Barhum Y, Ben-Zur T, Taler M, Hornfeld SH, Gil-Ad I, Weizman A, Slutsky I, Niwa M, Kamiya A, Sawa A, Offen D, Barzilay R
Human molecular genetics 2017 Jul 1;26(13):2462-2471

p21-activated kinase 1 restricts tonic endocannabinoid signaling in the hippocampus.

Xia S, Zhou Z, Leung C, Zhu Y, Pan X, Qi J, Morena M, Hill MN, Xie W, Jia Z
eLife 2016 Jun 14;5

Dominant negative DISC1 mutant mice display specific social behaviour deficits and aberration in BDNF and cannabinoid receptor expression.

Kaminitz A, Barzilay R, Segal H, Taler M, Offen D, Gil-Ad I, Mechoulam R, Weizman A
The world journal of biological psychiatry : the official journal of the World Federation of Societies of Biological Psychiatry 2014 Jan;15(1):76-82

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Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Cannabinoid receptor 1 antibody from Proteintech is a rabbit polyclonal antibody to a fusion protein of human Cannabinoid receptor 1. This antibody recognizes human,mouse,rat antigen. The Cannabinoid receptor 1 antibody has been validated for the following applications: ELISA, WB analysis.
Appendix: 17978-1-AP.pdf

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