Explore
Validate
Learn
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [924]
- Comments [0]
- Validations
- Western blot [1]
- Immunocytochemistry [1]
- Immunohistochemistry [2]
Submit
Validation data
Reference
Comment
Report error
- Product number
- 20960-1-AP - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#20960-1-AP, RRID:AB_10732601
- Product name
- HIF1a antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated HIF1a antibody (Cat. #20960-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Versatile Nanotherapeutics for Enhancing Sonodynamic Therapy/Chemotherapy of Thyroid Cancer through Remodeling Tumor Microenvironment and Synergistic Reactive Oxygen Species Augment.
SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis.
Taohong Siwu Decoction Regulates MSC-Mediated H-Type Angiogenesis to Accelerate Bone Fracture Healing Through VHL/HIF-1α Ubiquitination.
Characterization of Gastric Mucinous Carcinoma: Clinicopathological Insights and Vascular Features via MSCT.
Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis.
Hypoxia‑induced exosomal CAMTA1 promotes radio‑resistance in MDA‑MB‑231 cells by regulating NRG1 to mediate M2 macrophage polarization.
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR-HIF1α-LHDA Axis.
LINC01116 promotes glycolysis by up-regulating HIF-1α via YBX1-mediated dual mechanism in lung cancer.
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Live and heat-treated Lactiplantibacillus plantarum induce distinct metabolic and immune responses in intestinal epithelial cells.
TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer.
S100B induces angiogenesis via the clathrin/FOXO1/β-catenin signaling pathway and contributes to Bevacizumab resistance in epithelial ovarian cancer.
Magnesium ion implantation enhances the osseointegration and vascularization of 3D-Printed CoCrMo alloy scaffolds for load-bearing orthopedic applications.
HIF1A transcriptionally activates CDKN1A to drive ferroptosis in skeletal muscle ischaemia-reperfusion injury.
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment.
AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.
Distinct roles of lysophosphatidic acid (LPA) receptor signaling in regulating gastric cancer cell functions under chemical versus physiological hypoxia.
Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization.
Engineered Bacteria-Driven Biohybrid Microrobots Potentiate IL-2 Immunotherapy by Evoking Pyroptosis.
Alternations in the expression of hypoxia inducible factor 1 alpha (HIF1α) and selected angiogenesis-related genes in the hen ovary in relation to follicle development and atresia.
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Hypoxia-triggered dichloroacetate delivery with effective reversal of cancer cell reprogramming.
FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression.
Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity.
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.
GSH-Activated Cu-TCPP(Zn)/Ti(3)C(2)T(x) Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma.
Targeting HIF-1α promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer.
Integrated fabrication of a shape-adaptable, antioxidative composite stent for effective closure and biological repair of enteroatmospheric fistula.
circPLEKHM1 promotes tumor growth and metastasis through enhancing FXR1-mediated protein translation in PDAC.
HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.
Design, synthesis, and biological evaluation of selective cytotoxicity-derived Miliusol derivatives inducing profound TNBC regression in vivo.
GLT8D2-mediated PD-L1 N-glycosylation promotes tumor immune evasion in ovarian cancer peritoneal metastasis.
Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells.
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
NAT10-mediated ac4C modifications regulate glioblastoma progression.
Transcriptional mechanisms of hearing acclimatization to high altitude in rats.
Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway.
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Cell-free mitochondrial DNA as a potential predictor for hypoxic stress.
Targeting endolysosomal acidification inhibits poxvirus entry and replication.
Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress.
Catalase inhibits tumor growth by alleviating oxidative stress and promoting the polarization of tumor-associated macrophage from M2 to M1 phenotype in non-small cell lung cancer.
A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.
Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1.
Shen-Shuai-II-Recipe inhibits aerobic glycolysis through SIRT1 in 5/6 ablation/infarction renal failure model.
ALYREF expression correlated with upregulated YBX1 and HIF1α, contributing to cell migration in gastric cancer.
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer.
Protein tyrosine kinase Src suppresses hepatitis C virus particle release through regulation of Ndrg1.
Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities.
Engineered Gadolinium-Decorated Magnetic Resonance Nanoprobes for Enhanced Liver Fibrosis Theranostics.
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
DCC-2036 induces repolarization of TAMs to M1 type and enhances CD8(+) T cell immunity in TNBC.
Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma.
Asporin regulates glycolysis and stemness of gastric cancer cells.
Vascular normalization by erianin unleashes CAR-T immunotherapy in glioblastoma.
Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.
Modified Erxian Decoction ameliorates premature ovarian insufficiency via HIF-1α-mediated regulation of mitochondrial fission and oxidative stress.
Frehmaglutin F and frehmaglutin H ameliorate hypoxy-induced PASMCs injury via SIRT3/HIF-1α/PKM2 signal pathway.
Tanshinone IIA attenuates airway inflammation and airway remodeling in bronchial asthma by inhibiting p38/NF-κB and AKT/HIF-1α.
Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity.
Mitotic spindle-organizing protein 2A (MZT2A) promotes cisplatin resistance through NEMO ubiquitination and NF-κB activation in lung adenocarcinoma.
Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States.
CircRSU1 Activates the hnRNPA1/HIF-1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma.
Taurine stimulates EPO production in feline renal cells through the HIF pathway.
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Triptolide alleviates pathological neovascularisation in oxygen-induced retinopathy via inhibiting the inflammation mediated by NF-κB pathway.
LUCAT1/PTBP1/HIF-1α feedback loop promotes T cell over-differentiation and Th1/Th2-skewed immune imbalance in sepsis via glucose metabolism.
Hypofractionated radiotherapy followed by rhGM-CSF enhances immunogenic cell death in a murine model of pancreatic cancer.
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy.
Roxadustat: A catalyst for diabetic wound healing through re-epithelialization and angiogenesis.
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis.
Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.
Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway.
Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide.
Mechanistic Insights into Shenzhuo Formula for Diabetic Retinopathy: Integrating UPLC-Q-TOF-MS/MS, Network Pharmacology, Single-Cell RNA Sequencing Data, and Experimental Validation.
PEDF Alleviates Diabetic Renal Fibrosis by Degrading Kidney Ectopic Fat Deposition and Inhibiting Metabolic Reprogramming of Renal Tubular Epithelial Cells.
The molecular mechanism underlying angiogenesis in a mouse model of chronic kidney disease after ischemic stroke.
Hypoxia upregulate TPM4 expression to strengthen epithelial-mesenchymal transition that promotes lymph node metastasis of papillary thyroid cancer.
GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.
Fucoidan from Fucus vesiculosus alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration.
Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice.
Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach.
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.
Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway.
Characterization of hypoxia-related molecular clusters and prognostic riskScore for glioma.
Roxadustat regulates the cell cycle and inhibits proliferation of mesangial cells via the hypoxia-inducible factor-1α/P53/P21 pathway.
Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.
Daughter Cells Budding From PGCCs and Their Clinicopathological Significances in Oral Squamous Cell Carcinoma.
Microplastic exposure induces preeclampsia-like symptoms via HIF-1α/TFRC-mediated ferroptosis in placental trophoblast cells.
Discovery of Baicalein as a Novel Ubiquitin-Specific Protease 21 Inhibitor for the Treatment of Hepatocellular Carcinoma.
Regulation of macrophage phenotypes via NF-κB/NLRP3 and HIF1α/p53 pathways by fuco-galactoglucan from Agrocybe aegerita.
KDM4C regulates trophoblast proliferation and migration in preeclampsia via the NFATc4/Wnt pathway.
LncRNA H19 and miR-138 modulate retinal neovascularization and associated pathological features in hypoxia-induced disease models.
p67phox/NOX2 inhibits psoriasis by regulating the HIF-1α-glycolysis axis via p53-AMPK in keratinocytes.
Phytochemistry analysis of the above-ground parts of Sanguisorba officinalis L. and its effects on myocardial cell metabolism.
Neuroprotective effects of Rosavin via HIF-1α signaling in a rat model of ischemic stroke.
Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis.
Echinacoside targets the HIF-1α/LDHA axis to modulate A1/A2 astrocyte differentiation and promote glial scar repair following ischemic stroke.
Propionate alleviated colitis by modulating iron homeostasis to inhibit ferroptosis and macrophage polarization.
Identification of autophagy-related biomarkers in the circulatory system of ischemic stroke.
Glucose-Fueled Histone Modifications Drive HIV-1 Latency Reversal at Hypoxia.
Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming.
Curcumin inhibits aortic dissection progression: Insights from the integrated analysis of network pharmacology, gut microbiota, and serum metabolomics.
YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer.
Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses.
KIF4A Promotes Glioblastoma Malignant Progression and Transmission of Temozolomide Resistance in the Tumor Microenvironment via the HIF1A/VEGFA Axis.
The oncogenic role of CCDC34 in lower-grade gliomas: prognostic significance and therapeutic potential.
A Novel Injectable Composite Hydrogel HAp-GelMA Co-Doped Magnesium/Zinc Promotes Bone Generation and Angiogenesis Synergistically.
Harpagide Confers Protection Against Acute Lung Injury Through Multi-Omics Dissection of Immune-Microenvironmental Crosstalk and Convergent Therapeutic Mechanisms.
Rutin alleviates preoperative anxiety stress-induced persistent postoperative pain by inhibiting microglia-mediated abnormal synaptic engulfment in the spinal cord dorsal horn.
Molecules interacting with CasL-Like 2 enhances tumor angiogenesis and progression by activating mTOR/HIF1α/VEGF pathway in kidney renal clear cell carcinoma.
Mechanism of retinal angiogenesis induced by HIF-1α and HIF-2α under hyperoxic conditions.
Mitochondrial ribosomal protein L12 mediates metabolic reorganization in clear cell renal cell carcinoma by regulating mitochondrial biosynthesis.
GDF15 attenuates sepsis-induced acute lung injury by suppressing the HIF-1α/LDHA pathway.
Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation.
Baicalin promotes anti-tumor immunity in hepatocellular carcinoma through HIF-1α/Lactate/CXCL9 axis.
Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity.
Osteocyte Neuropeptide Y Aggravates Bone Loss in OVX Mice by Inhibiting Preosteoclast Proliferation and PDGF-BB-Induced Type H Vessel Formation Through PI3K/Akt Signaling Pathway.
Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.
Lineage plasticity and signal dysregulation define the cellular trajectory of osteoarthritis progression.
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
PFKFB4 promotes endometrial cancer by regulating glycolysis through SRC‑3 phosphorylation.
Divalent metal ions enhance bone regeneration through modulation of nervous systems and metabolic pathways.
Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.
Enhancing temozolomide efficacy in GBM: The synergistic role of chuanxiong rhizoma essential oil.
Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC.
The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis.
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.
Hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor AMSP-30 m attenuates CCl(4)-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway.
Exosomal PD-L1 derived from hypoxia nasopharyngeal carcinoma cell exacerbates CD8(+) T cell suppression by promoting PD-L1 upregulation in macrophages.
SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis.
Edaravone dexborneol provides neuroprotective benefits by suppressing ferroptosis in experimental intracerebral hemorrhage.
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway.
Hsp90 and HIF-1α regulate mitophagy by promoting BNIP3 expression in renal ischemia-reperfusion injury.
Hypoxia-inducible factor-1α inhibitor promotes non-alcoholic steatohepatitis development and increases hepatocellular lipid accumulation via TSKU upregulation.
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.
Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.
Ultrasound-Triggered Oxygen Release System for Accelerating Wound Healing of Diabetic Foot Ulcers.
Uric acid promotes aortic valve calcification via mediating valve interstitial cell osteogenic differentiation and endothelial dysfunction.
Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer.
Amniotic fluid-derived exosomal miR-146a-5p ameliorates preeclampsia phenotypes by inhibiting HIF-1α/FLT-1 expression.
Curcumin inhibits ferroptosis-mediated vascular occlusion by regulating the CXCL10/CXCR3 axis in retinopathy of prematurity.
Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia.
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Puerarin Targets HIF-1α to Modulate Hypoxia-Related Sphingolipid Metabolism in Diabetic Hepatopathy via the SPTLC2/Ceramide Pathway.
Rifaximin Inhibits Small Bowel Angiodysplasia-Associated Angiogenesis by Attenuating LncRNA-HIF1A-AS2/miR-153-3p/HIF-1 α/Ang-2 Axis.
Exploring the mechanism of Shenhua tablet alleviating renal injury by regulating macrophage glycolysis hypoxia-inducible factor-1α/ pyruvate kinase M2 signaling pathway in diabetic kidney disease mice.
ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment.
Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling.
Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.
PTEN/PI3K/AKT pathway activation with hypoxia-induced human umbilical vein endothelial cell exosome for angiogenesis-based diabetic skin reconstruction.
Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production.
Antitumour and anti-angiogenesis efficacy of a multifunctional self-oxygenated active-targeting drug delivery system by encapsulating biological and chemotherapeutic drugs.
IL-21 Loading CaMnCO(3) Vitality Backpacks Boost CAR-T Cell Synergistic Immunotherapy.
Triiodothyronine promotes the proliferation and chemoresistance of cholangiocarcinoma cells via HIF-1α/Glut1-stimulated glycolysis.
Hif-1α regulation of the Tet1-β-catenin-Dicer1-miRNAs pathway is involved in depression-like behavior in prenatal hypoxic male offspring.
Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy.
Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer.
ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer.
Platelet Membrane-Coated Drug-Loaded Nanoparticles for Dual-Modal Imaging and Photodynamic Therapy in Triple-Negative Breast Cancer.
Establishment of cell size-dependent growth rate via differential scaling of metabolite uptake and release.
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
Investigating the Therapeutic Potential of Salvianolic Acid B in Ischemic Wound Healing: In Vivo and In Vitro Study.
Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche.
Biofabricated Adipose-Derived Mesenchymal Cell Sheets Recover Cryo-Injured Kidneys in Rats.
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α.
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.
A High-Calorie Diet Aggravates Lipopolysaccharide-Induced Pulmonary Inflammation in Juvenile Rats via Hypothalamic-Pituitary-Adrenal Axis-Related Pathways.
Treatment targets of cellular senescence and circadian rhythms in ischemic stroke.
Hypoxia-mediated HES4 promotes the proliferation and motility of hepatocellular carcinoma cell by enhancing COL4A2 transcription.
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma.
Expression and clinical significance of AUF1 and HIF-1α in papillary thyroid carcinoma.
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.
THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation.
Tea polyphenols nanoparticles integrated with microneedles multifunctionally boost 5-aminolevulinic acid photodynamic therapy for skin cancer.
PGK1 Is Involved in the HIF-1 Signaling Pathway as a Hub Gene for Ferroptosis After Traumatic Brain Injury.
Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling.
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.
Morusin Reverses Epithelial-Mesenchymal Transition in Gallbladder Cancer Cells by Regulating STAT3/HIF-1α Signaling.
CircFAM64A(3) promoted bladder cancer proliferation and inhibited CD8 + T cell via sponging to miR-149-5p and activated IL-6/JAK/STAT pathway.
Detection of serum lactate dehydrogenase A and its metabolites on placental function in patients with intrahepatic cholestasis of pregnancy.
Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239.
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.
LncRNA TUG1 mitigates chronic kidney disease through miR-542-3p/HIF-1α/VEGF axis.
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Hypoxia-responsive liposome enhances intracellular delivery of photosensitizer for effective photodynamic therapy.
Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival.
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.
HSPA5-mediated glioma hypoxia tolerance promotes M2 macrophage polarization under hypoxic microenvironment.
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy.
Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling.
Specific effects of hypoxia-immune core gene ARHGAP11A on lung adenocarcinoma.
AR Deficiency Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Macrophage M1 Polarization and Inflammatory Cytokine Secretion.
VH032 suppresses glioma proliferation by inhibiting the VHL/HIF-1α/VEGF pathway.
An injectable phosphocreatine-grafted hydrogel incorporating hierarchically structured teriparatide/SrZnP-functionalized Zn-Cu particles for osteogenesis-angiogenesis coupling and osteoporotic bone regeneration.
STC2 Serves as a Critical Hypoxic Effector in Keloid Pathogenesis by Orchestrating Fibroblasts Activation and ECM Remodelling.
Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication.
N-formyl methionine mediates NETosis of neutrophil to promote sepsis-induced cardiomyopathy via the FPR1 pathway.
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance.
Hypoxia induced VEGF secretion promotes resistance to bispecific T-cell engagers.
Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy.
De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming.
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Chiral nanoassembly remodels tumor microenvironment through non-oxygen-dependent depletion lactate for effective photodynamic immunotherapy.
A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment.
Cr (VI) induces lactate utilization through HIF-1α/MCT1 dependent on p53 protein level.
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth.
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
Succinate links TCA cycle dysfunction to inflammation by activating HIF-1α signaling in acute kidney injury.
CircCRIM1 promotes the translation of HIF-1α protein through its interaction with PTBP3 and enhances malignant progression and angiogenesis in glioblastoma.
Synergistic Neuroprotection of Artesunate and Tetramethylpyrazine in Ischemic Stroke, Mechanisms of Blood-Brain Barrier Preservation.
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway.
Inulin and hyaluronic acid-based oral liposome for enhanced photo-chemotherapy against orthotopic colon cancer and its reversal effects on tumor hypoxia and intestinal microbiota.
Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia.
Sodium Hyaluronate-PDGF Repairs Cartilage and Subchondral Bone Microenvironment via HIF-1α-VEGF-Notch and SDF-1-CXCR4 Inhibition in Osteoarthritis.
Hypoxia amplifies arecoline-induced invasion and metastasis in oral squamous cell carcinoma - Insights into TGF-β1 signaling and collagen production.
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
The Role of Hippo Signaling in Brain Arteriovenous Malformations: Molecular Insights into Post-Embolization Remodeling.
Estrogen receptor β alleviates colitis in intestinal epithelial cells and activates HIF-1a and ATG-9a-mediated autophagy.
Hypoxia-regulated miR-103-3p/FGF2 axis in adipose-derived stem cells promotes angiogenesis by vascular endothelial cells during ischemic tissue repair.
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage.
Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
The mouse gingiva and HIF-1α, a key gene of hypoxic environment, as tools for post-mortem time estimation.
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma.
Benserazide, a cystathionine beta-synthase (CBS) inhibitor, potentially enhances the anticancer effects of paclitaxel via inhibiting the S-sulfhydration of SIRT1 and the HIF1-α/VEGF pathway.
Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ.
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.
Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2.
Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.
PLAUR facilitates the progression of clear cell renal cell carcinoma by activating the PI3K/AKT/mTOR signaling pathway.
Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing.
The tourniquet's effects on skeletal muscle during total knee arthroplasty.
Cyclophilin J limits linear ubiquitin signaling and controls colorectal cancer progression.
The miR-199a-5p/HIF1α dual-regulatory axis participates in hypoxia-induced aggressive phenotypes of oral squamous cell carcinoma (OSCC) cells.
Stable and oscillatory hypoxia differentially regulate invasibility of breast cancer associated fibroblasts.
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
Hypoxia activates the hypoxia-inducible factor-1α/vascular endothelial growth factor pathway in a prostatic stromal cell line: A mechanism for the pathogenesis of benign prostatic hyperplasia.
Enhanced glioma cell death with ZnO nanorod flowers and temozolomide combination therapy through autophagy and mitophagy pathways.
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells.
Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents.
Intratumoral CXCL13(+) CD160(+) CD8(+) T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer.
HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.
RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs.
KRT19 is regulated by miR-642a-5p and promotes pancreatic cancer progression through the Wnt/β-catenin pathway.
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma.
Electroacupuncture enhances cerebral blood perfusion by inhibiting HIF-1α in rat subarachnoid hemorrhage.
Hypoxia-induced Semaphorin 3A promotes the development of endometriosis through regulating macrophage polarization.
BCLAF1 is Expressed as a Potential Anti-oncogene in Bile Duct Cancer.
Transcription Factor TFAP2B Exerts Neuroprotective Effects Targeting BNIP3-Mediated Mitophagy in Ischemia/Reperfusion Injury.
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia.
Disruption of BACH1 Protects AC16 Cardiomyocytes Against Hypoxia/Reoxygenation-Evoked Injury by Diminishing CDKN3 Transcription.
Enhancing Endogenous Hyaluronic Acid in Osteoarthritic Joints with an Anti-Inflammatory Supramolecular Nanofiber Hydrogel Delivering HAS2 Lentivirus.
The effects of BMP2 and the mechanisms involved in the invasion and angiogenesis of IDH1 mutant glioma cells.
Non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy promote diabetic wound healing.
The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation.
TRIM55 restricts the progression of hepatocellular carcinoma through ubiquitin-proteasome-mediated degradation of NF90.
HIF-1α knockdown suppresses breast cancer metastasis via epithelial mesenchymal transition Abrogation.
SOX9 promotes hypoxic pulmonary hypertension through stabilization of DPP4 in pulmonary artery smooth muscle cells.
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Downregulation of C1R promotes hepatocellular carcinoma development by activating HIF-1α-regulated glycolysis.
SPAG4 enhances mitochondrial respiration and aerobic glycolysis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.
Association of the podocyte phenotype with extracapillary hypercellularity in patients with diabetic kidney disease.
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism.
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway.
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.
Targeted inhibition of CHKα and mTOR in models of pancreatic ductal adenocarcinoma: A novel regimen for metastasis.
Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment.
Influenza A virus-induced glycolysis facilitates virus replication by activating ROS/HIF-1α pathway.
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway.
EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway.
Proteomic analysis reveals the mechanism that low molecular weight hyaluronic acid enhances cell migration in keratinocyte.
Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus.
Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment.
One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects.
Triggered Cascade-Activation Nanoplatform to Alleviate Hypoxia for Effective Tumor Immunotherapy Guided by NIR-II Imaging.
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Hypoxia inducible factor-1α facilitates transmissible gastroenteritis virus replication by inhibiting type I and type III interferon production.
Prognostic biomarker HIF1α and its correlation with immune infiltration in gliomas.
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.
The Bufei Nashen pill inhibits the PI3K/AKT/HIF-1 signaling pathway to regulate extracellular matrix deposition and improve COPD progression.
The Bioactive Compounds of Epimedium and Their Potential Mechanism of Action in Treating Osteoporosis: A Network Pharmacology and Experimental Validation Study.
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis.
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway.
The down-regulation of STC2 mRNA may serve as a biomarker for death from mechanical asphyxia.
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
Light-Enhanced Hypoxia-Responsive Gene Editing for Hypoxia-Resistant Photodynamic and Immunotherapy.
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway.
Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.
FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation.
Bi(2)S(3)/Ti(3)C(2)-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Sustained AhR activity programs memory fate of early effector CD8(+) T cells.
The Anti-Atherosclerotic Effects of Buyang Huanwu Decoction through M1 and M2 Macrophage Polarization in an ApoE Knockout Mouse Model.
Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia.
The human testis-enriched HSPA2 interacts with HIF-1α in epidermal keratinocytes, yet HIF-1α stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity.
The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α-ACER2-Ceramide Signaling Axis.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α.
Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis.
The Role of TPM3 in Protecting Cardiomyocyte from Hypoxia-Induced Injury via Cytoskeleton Stabilization.
Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis.
MATN4 as a target gene of HIF-1α promotes the proliferation and metastasis of osteosarcoma.
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.
Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Hypoxia-mediated attenuation of EGLN2 inhibition of the NF-κB signaling pathway leads to the formation of a loop between HIF-1α and MUC1-C promoting chemoresistance in bladder cancer.
Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Scavenger Receptor Class B Type I Deficiency Induces Iron Overload and Ferroptosis in Renal Tubular Epithelial Cells via Hypoxia-Inducible Factor-1α/Transferrin Receptor 1 Signaling Pathway.
PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α.
Hypoxia-responsive lncRNA MIR155HG promotes PD-L1 expression in hepatocellular carcinoma cells by enhancing HIF-1α mRNA stability.
AUY922 improves sensitivity to sunitinib in clear cell renal cell carcinoma based on network pharmacology and in vitro experiments.
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
Single-cell transcriptomic insights into chemotherapy-induced remodeling of the osteosarcoma tumor microenvironment.
Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma.
The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis.
HIF-1α Contributes to Hypoxia-induced VSMC Proliferation and Migration by Regulating Autophagy in Type A Aortic Dissection.
Hypoxic microenvironment promotes dermal fibroblast migration and proliferation via a BNIP3-autophagy pathway.
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron Efflux.
NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells.
Meta-analysis identifying gut microbial biomarkers of Qinghai-Tibet Plateau populations and the functionality of microbiota-derived butyrate in high-altitude adaptation.
A Self-Homing and Traceable Cardiac Patch Leveraging Ferumoxytol for Spatiotemporal Therapeutic Delivery.
HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer.
The HIF-1/ BNIP3 pathway mediates mitophagy to inhibit the pyroptosis of fibroblast-like synoviocytes in rheumatoid arthritis.
HIF-1α/METTL1/m(7)G axis is involved in CRC response to hypoxia.
Inhibition of glioblastoma cell proliferation and invasion by the choline-kinase inhibitor JAS239 varies with cell type and hypoxia.
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α.
LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis.
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner.
BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma.
HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones.
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma.
Targeted regulation of autophagy using sorafenib-loaded biomineralization nanoenzyme for enhanced photodynamic therapy of hepatoma.
Identification of potential characteristic genes in chronic skin infections through RNA sequencing and immunohistochemical analysis.
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma.
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Quercetin inhibits malignant progression of high metastatic advanced colon cancer in hypoxia via suppressing ROS and PI3K/AKT pathway.
Dual-activity nanozyme as an oxygen pump to alleviate tumor hypoxia and enhance photodynamic/ NIR-II photothermal therapy for sniping oral squamous cell carcinoma.
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.
Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis.
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.
Novel serous effusion-related risk models and biomarkers for predicting prognosis in T-cell lymphoma patients.
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.
DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3.
EIF2S2 transcriptionally upregulates HIF1α to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.
The IL-10/STAT3 Axis Nasopharyngeal Carcinoma Cancer stem cell and radio resistance.
Transposable element exonization generates a reservoir of evolving and functional protein isoforms.
A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention.
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
Induction of Peroxiredoxin 1 by Hypoxia Promotes Cellular Autophagy and Cell Proliferation in Oral Leukoplakia via HIF-1α/BNIP3 Pathway.
High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.
Laponite/lactoferrin hydrogel loaded with eugenol for methicillin-resistant Staphylococcus aureus-infected chronic skin wound healing.
SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1α.
Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy.
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation.
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis.
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
Carrier-Free Hybrid Nanoparticles for Enhanced Photodynamic Therapy in Oral Carcinoma via Reversal of Hypoxia and Oxidative Resistance.
Therapeutic potential of flavopiridol in diabetic retinopathy: Targeting DDX58.
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis.
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Exploration of the underlying mechanism of Astragaloside III in attenuating immunosuppression via network pharmacology and vitro/vivo pharmacological validation.
Hypoxia-inducible factor-1α contributes to the proliferation of cholesteatoma keratinocytes through regulating endothelin converting enzyme 1 expression.
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps.
Preclinical multi-physiologic monitoring of immediate-early responses to diverse treatment strategies in breast cancer by optoacoustic imaging.
Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.
Single-cell RNA sequencing of pediatric renal tissues revealed the potential relationship between immunoglobulin A nephropathy and immunoglobulin A vasculitis with nephritis.
Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.
Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid.
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors.
Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia.
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer.
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Cascade-Catalyzed Nanogel for Amplifying Starvation Therapy by Nitric Oxide-Mediated Hypoxia Alleviation.
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway.
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
Slc6a13 Deficiency Attenuates Pasteurella multocida Infection-Induced Inflammation via Glycine-Inflammasome Signaling.
Large-Scale Identification of Lysine Crotonylation Reveals Its Potential Role in Oral Squamous Cell Carcinoma.
Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis.
Unveiling the role of hypoxic macrophage-derived exosomes in driving colorectal cancer progression.
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α.
Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.
Chronic intermittent hypobaric hypoxia ameliorates osteoporosis after spinal cord injury through balancing osteoblast and osteoclast activities in rats.
The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect.
MK8617 inhibits M1 macrophage polarization and inflammation via the HIF-1α/GYS1/UDPG/P2Y(14) pathway.
Expression of hypoxia-inducing factor-1α and matrix metalloproteinase-9 in the recipient parasylvian cortical arteries with different hemodynamic sources in adult moyamoya disease.
Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression.
Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy.
UBE2S promotes malignant properties via VHL/HIF-1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma.
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Bioengineered "Molecular Glue"-Mediated Tumor-Specific Cascade Nanoreactors with Self-Destruction Ability for Enhanced Precise Starvation/Chemosynergistic Tumor Therapy.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway.
Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis.
Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice.
Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-κB/HIF-1α/Twist1 pathway.
An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.
Astragaloside IV Inhibited Podocyte Pyroptosis in Diabetic Kidney Disease by Regulating SIRT6/HIF-1α Axis.
Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.
Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.
FTY-720 alleviates diabetes-induced liver injury by inhibiting oxidative stress and inflammation.
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
CircABPD1 alleviates oxidative lung injury of bronchopulmonary dysplasia through regulating miR-330-3p/HIF1α axis.
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.
Mechanism of the HIF-1α/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells.
Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent.
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis.
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
Pancreatic Ductal Adenocarcinoma: The Characteristics of Contrast-Enhanced Ultrasound Are Correlated with the Hypoxic Microenvironment.
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer.
NARFL deficiency caused mitochondrial dysfunction in lung cancer cells by HIF-1α-DNMT1 axis.
Neutrophil extracellular traps boost laser-induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF-1α pathway.
HIF‑1α and RACGAP1 promote the progression of hepatocellular carcinoma in a mutually regulatory way.
Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis.
A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.
Ferrostatin-1 attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis.
Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation.
The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.
Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model.
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia.
Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression†.
PI3K/AKT signaling activates HIF1α to modulate the biological effects of invasive breast cancer with microcalcification.
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Diagnosis of asphyxiation in advanced decomposed corpses by using Oil-Red-O Stain and immunohistochemical technology.
MSC-EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF-1α.
The HIF-1α/miR-26a-5p/PFKFB3/ULK1/2 axis regulates vascular remodeling in hypoxia-induced pulmonary hypertension by modulation of autophagy.
Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization.
Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer.
Clinical and pathological features analysis of invasive breast cancer with microcalcification.
Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.
Eriocitrin attenuates sepsis-induced acute lung injury in mice by regulating MKP1/MAPK pathway mediated-glycolysis.
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.
Single-cell transcriptomics of human-skin-equivalent organoids.
DiDang decoction improves mitochondrial function and lipid metabolism via the HIF-1 signaling pathway to treat atherosclerosis and hyperlipidemia.
Effect of miR‑29a‑3p in exosomes on glioma cells by regulating the PI3K/AKT/HIF‑1α pathway.
LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis.
ROS-activated MAPK/ERK pathway regulates crosstalk between Nrf2 and Hif-1α to promote IL-17D expression protecting the intestinal epithelial barrier under hyperoxia.
Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.
NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma.
Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway.
Hypoxia-Induced Kidney Injury in Newborn Rats.
Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a nutrient-oxygen gradient interference.
Photodynamic therapy enhances the cytotoxicity of temozolomide against glioblastoma via reprogramming anaerobic glycolysis.
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis.
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes.
Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.
Type H vessel/platelet-derived growth factor receptor β(+) perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage.
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
5‑aminiolevulinic acid induces a radiodynamic effect with enhanced delayed reactive oxygen species production under hypoxic conditions in lymphoma cells: An in vitro study.
Immune-independent acquired resistance to PD-L1 antibody initiated by PD-L1 upregulation via PI3K/AKT signaling can be reversed by anlotinib.
Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells.
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
Two-in-One Polymeric NO-Donor Prodrugs Mediate Precision and Synergistic Prostate Cancer Treatment.
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.
Deciphering the Mechanism of Wogonin, a Natural Flavonoid, on the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Integrating Network Pharmacology and In Vitro Validation.
EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage.
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension.
Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats.
Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.
Augmenting Intracellular Cargo Delivery of Extracellular Vesicles in Hypoxic Tissues through Inhibiting Hypoxia-Induced Endocytic Recycling.
Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis.
Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway.
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
SND1, a novel co-activator of HIF1α, promotes tumor initiation in PyMT-induced breast tumor.
Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.
The interplay between H19 and HIF-1α in mitochondrial dysfunction in myocardial infarction.
Exploration of the Pharmacological Mechanism of Vitexicarpin against Triple-Negative Breast Cancer in Network Pharmacology.
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Fluorinated Cell-Penetrating Peptide for Co-Delivering siHIF-1α and Sorafenib to Enhance In Vitro Anti-Tumor Efficacy.
O(2)-Generating Fluorescent Carbon Dot-Decorated MnO(2) Nanosheets for "Off/On" MR/Fluorescence Imaging and Enhanced Photodynamic Therapy.
Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype.
Hypoxia induces the production of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis with nasal polyps.
Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats.
TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts.
IGF2BP3/HIF1A/YAP signaling plays a role in driving acute-on-chronic liver failure through activating hepatocyte reprogramming.
Hypoxic tumor-derived exosomal miR-21 induces cancer-associated fibroblast activation to promote head and neck squamous cell carcinoma metastasis.
Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
Luteolin attenuates lupus nephritis by regulating macrophage oxidative stress via HIF-1α pathway.
E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.
P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer.
Lactate modulates microglial inflammatory responses after oxygen-glucose deprivation through HIF-1α-mediated inhibition of NF-κB.
Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.
CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis.
LINC00365 functions as a tumor suppressor by inhibiting HIF-1α-mediated glucose metabolism reprogramming in breast cancer.
IL-7-Treated Periodontal Ligament Cells Regulate Local Immune Homeostasis by Modulating Treg/Th17 Cell Polarization.
HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.
Salvianolic Acid Ameliorates Pressure Overload-Induced Cardiac Endothelial Dysfunction via Activating HIF1[Formula: see text]/HSF1/CD31 Pathway.
Bovine milk exosomes affected proliferation of macrophages under hypoxia.
Effect of hydroxyapatite bioceramics on the growth of osteoblasts and HIF-α/VEGF signal axis in partial hypoxia environment in vitro.
IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.
Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress.
Inhibition of KCTD10 Affects Diabetic Retinopathy Progression by Reducing VEGF and Affecting Angiogenesis.
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
ROS Promote Hypoxia-Induced Keratinocyte Epithelial-Mesenchymal Transition by Inducing SOX2 Expression and Subsequent Activation of Wnt/β-Catenin.
A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signalling.
Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Modified Qing' e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation.
Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α.
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization.
Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p.
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
WWOX-rs13338697 genotype predicts therapeutic efficacy of ADI-PEG 20 for patients with advanced hepatocellular carcinoma.
Multitranscriptome analyses of keloid fibroblasts reveal the role of the HIF-1α/HOXC6/ERK axis in keloid development.
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
HIF‑1α and MBP1 are associated with the progression of breast cancer cells by repressing β‑catenin transcription.
Inhibition of hypoxia-inducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy.
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model.
Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells.
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Transgenic construction and functional miRNA analysis identify the role of miR-7 in prostate cancer suppression.
Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function.
Reticulocalbin3: A Ca(2+) homeostasis regulator that promotes esophageal squamous cell carcinoma progression and cisplatin resistance.
HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1α/HEY1 Signaling Pathway.
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Ti(3) C(2) T(x) MXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids.
Cancer-associated fibroblast-secreted miR-421 promotes pancreatic cancer by regulating the SIRT3/H3K9Ac/HIF-1α axis.
Engineered biomimetic nanoreactor for synergistic photodynamic-chemotherapy against hypoxic tumor.
Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy.
Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling.
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Sinensetin suppresses angiogenesis in liver cancer by targeting the VEGF/VEGFR2/AKT signaling pathway.
Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway.
A novel hypoxia-driven gene signature that can predict the prognosis of hepatocellular carcinoma.
Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation.
RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin.
microRNA-671-5p reduces tumorigenicity of ovarian cancer via suppressing HDAC5 and HIF-1α expression.
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment.
Effects of endurance training on metabolic enzyme activity and transporter protein levels in the skeletal muscles of orchiectomized mice.
Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis.
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis.
LncRNA HOTTIP PROMOTES OVARIAN CANCER CELL INVASION AND METASTASIS BY STABILIZING HIF-1α IN THE ANOXIC CELLULAR MICROENVIRONMENT.
LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia.
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
A maternal high-fat diet induces fetal origins of NASH-HCC in mice.
Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1α/TGF-β1/SMAD pathway.
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages.
Hsa_circ_0019054 up-regulates HIF1A through sequestering miR-340-5p to promote the tumorigenesis of intrahepatic cholangiocarcinoma.
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.
Intraperitoneal Triamcinolone Reduces Postoperative Adhesions, Possibly through Alteration of Mitochondrial Function.
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of HIF-1α and ANGPT2.
Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy.
Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma.
Membrane progesterone receptor α (mPRα) enhances hypoxia-induced vascular endothelial growth factor secretion and angiogenesis in lung adenocarcinoma through STAT3 signaling.
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.
Caveolin-1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole-rats.
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes.
Nanoscale CaO(2) materials for synergistic transarterial chemoembolization in a VX2 orthotopic rabbit liver cancer model.
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Protective effects of Gypenoside XVII against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy.
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Resveratrol Ameliorates Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease via the Autophagy-Lysosome Pathway.
ACAP1 Deficiency Predicts Inferior Immunotherapy Response in Solid Tumors.
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.
Forkhead box A2 transcriptionally activates hsa-let-7 g to inhibit hypoxia-induced epithelial-mesenchymal transition by targeting c14orf28 in colorectal cancer.
High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.
Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma.
HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Cell-Type Dependent Regulation of the Electrogenic Na(+)/HCO(3)(-) Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma.
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Semaphorin 3A attenuates the hypoxia suppression of osteogenesis in periodontal ligament stem cells.
TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma.
Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.
SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.
Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors.
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Metastatic Transition of Pancreatic Ductal Cell Adenocarcinoma Is Accompanied by the Emergence of Pro-Invasive Cancer-Associated Fibroblasts.
Hypoxia Alters the Proteome Profile and Enhances the Angiogenic Potential of Dental Pulp Stem Cell-Derived Exosomes.
MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway.
Notch1 activation of Jagged1 contributes to differentiation of mesenchymal stem cells into endothelial cells under cigarette smoke extract exposure.
SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma.
Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α.
TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair.
miR-125b enhances metastasis and progression of cancer via the TXNIP and HIF1α pathway in pancreatic cancer.
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy.
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions.
LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis.
Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β.
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
P4HA1 as an unfavorable prognostic marker promotes cell migration and invasion of glioblastoma via inducing EMT process under hypoxia microenvironment.
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis.
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma.
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.
Hypoxic colorectal cancer-secreted exosomes deliver miR-210-3p to normoxic tumor cells to elicit a protumoral effect.
Mitochondrial calcium uniporter promotes cell proliferation and migration in esophageal cancer.
LncRNA ZNFTR functions as an inhibitor in pancreatic cancer by modulating ATF3/ZNF24/VEGFA pathway.
Assessing the protective effects of cryptotanshinone on CoCl(2)‑induced hypoxia in RPE cells.
Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets.
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis.
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Ultrathin 2D Titanium Carbide MXene (Ti(3) C(2) T(x) ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone.
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.
The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway.
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Trim47 overexpression correlates with poor prognosis in gastric cancer.
The Expression and Role of Hypoxia-induced Factor-1α in Human Tenon's Capsule Fibroblasts under Hypoxia.
SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
The essential role of PRAK in tumor metastasis and its therapeutic potential.
p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
High expression of NDRG3 in osteoarthritis patients.
Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells.
A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism.
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Thioredoxin-interacting protein is a favored target of miR-125b, promoting metastasis and progression of pancreatic cancer via the HIF1α pathway.
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.
Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF-1α under a hypoxic microenvironment.
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells.
Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis.
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species.
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1α in clear cell renal cell carcinoma.
BML-111, the lipoxin A(4) agonist, modulates VEGF or CoCl(2)-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models.
microRNA-322/424 promotes liver fibrosis by regulating angiogenesis through targeting CUL2/HIF-1α pathway.
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.
A single-cell transcriptomic landscape of the lungs of patients with COVID-19.
Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.
miR-126 regulates angiogenesis in myocardial ischemia by targeting HIF-1α.
Inhibitory effect of maspinon neovascularization in diabetic retinopathy.
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Lysosome Fe(2+) release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.
Leptin attenuates hypoxia-induced apoptosis in human periodontal ligament cells via the reactive oxygen species-hypoxia-inducible factor-1α pathway.
USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma.
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.
Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition.
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway.
The Regulatory Mechanism and Biological Significance of Mitochondrial Calcium Uniporter in the Migration, Invasion, Angiogenesis and Growth of Gastric Cancer.
Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer.
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma.
Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma.
Human Umbilical Cord Mesenchymal Stem Cell Differentiation Into Odontoblast-Like Cells and Endothelial Cells: A Potential Cell Source for Dental Pulp Tissue Engineering.
Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System.
Characterization of Group I Metabotropic Glutamate Receptors in Rat and Human Adrenal Glands.
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a.
Therapeutic effects of Choreito, a traditional Japanese (Kampo) medicine, on detrusor overactivity induced by acetic acid in rats.
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner.
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway.
USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer.
Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma.
Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis.
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
LncRNA HOTAIR knockdown inhibits glycolysis by regulating miR-130a-3p/HIF1A in hepatocellular carcinoma under hypoxia.
Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway.
P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.
Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation.
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.
Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC.
Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α.
Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma.
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Severe OSA associated with higher risk of mortality in stage III and IV lung cancer.
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells.
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a.
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.
Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.
Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia.
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction.
LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α.
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Aspirin, a Potential GLUT1 Inhibitor in a Vascular Endothelial Cell Line.
Proinflammatory-factors-carrying-microvesicles from monocytes induced by high glucose enhance the activation of HIF/VEGF pathway in human renal mesangial cells.
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway.
Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization.
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Rubidium-Containing Calcium Alginate Hydrogel for Antibacterial and Diabetic Skin Wound Healing Applications.
Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals.
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia.
DZNep inhibits Hif-1α and Wnt signalling molecules to attenuate the proliferation and invasion of BGC-823 gastric cancer cells.
Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis.
RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway(✰).
Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma.
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.
Inhibiting Hypoxia and Chemotherapy-Induced Cancer Cell Metastasis under a Valid Therapeutic Effect by an Assistance of Biomimetic Oxygen Delivery.
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.
Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment.
Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.
Transplantation of Amniotic Fluid-Derived Stem Cells Preconditioned with Glial Cell Line-Derived Neurotrophic Factor Gene Alleviates Renal Fibrosis.
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury.
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.
Extremely Effective Chemoradiotherapy by Inducing Immunogenic Cell Death and Radio-Triggered Drug Release under Hypoxia Alleviation.
Nicotine-induced hypoxia in rat urothelium deteriorates bladder storage functions.
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Epithelial-mesenchymal transition induced cancer-stem-cell-like characteristics in hepatocellular carcinoma.
Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α.
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway.
FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization.
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α.
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.
Expression of glucose transporter-1, hypoxia inducible factor-1α and beclin-1 in head and neck cancer and their implication.
High HIF-1α expression predicts poor prognosis of patients with colon adenocarcinoma.
Gli1, a potential cancer stem cell marker, is strongly associated with prognosis in prostate cancer.
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Recombinant human maspin inhibits high glucose-induced oxidative stress and angiogenesis of human retinal microvascular endothelial cells via PI3K/AKT pathway.
SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment.
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.
Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation.
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma.
Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy.
Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders.
Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance.
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis.
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
V-ATPase-dependent repression of androgen receptor in prostate cancer cells.
Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum.
Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models.
Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling.
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo.
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis.
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.
Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy.
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells.
Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma.
Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
BNIP3 promotes the motility and migration of keratinocyte under hypoxia.
In vivo evaluation of the effects of simultaneous inhibition of GLUT-1 and HIF-1α by antisense oligodeoxynucleotides on the radiosensitivity of laryngeal carcinoma using micro 18F-FDG PET/CT.
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration.
Discordant mRNA and protein expression of CXCR4 under in vitro CoCl(2)-induced hypoxic conditions.
Regulation of angiogenic behaviors by oxytocin receptor through Gli1-indcued transcription of HIF-1α in human umbilical vein endothelial cells.
Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis.
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.
Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α.
Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138.
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice.
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.
Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.
Preparation of artificial red cell and its application on alleviation of tumor hypoxia.
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression.
Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion.
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function.
Hydrogen Sulfide and Carbon Monoxide Protect Gastric Mucosa Compromised by Mild Stress Against Alendronate Injury.
Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression.
Association between the expression of HIF-1α and VEGF and prognostic implications in primary liver cancer.
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.
Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model.
Paper-based microreactor array for rapid screening of cell signaling cascades.
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer.
The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer.
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma.
DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.
Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells.
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.
Interferon-γ-induced intestinal epithelial barrier dysfunction by NF-κB/HIF-1α pathway.
Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: angiogenic markers of neoadjuvant chemoradiation.
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer.
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.
Valsartan inhibited HIF-1α pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats.
Wang D, Sun L, Wang J, Wang L, Wang Z, Zhang Y, Zhou Q, Chen Y, Jiang J
Biomaterials research 2026;30:0338
Biomaterials research 2026;30:0338
SHP2 improved Late-onset fetal growth restriction via modulating ROS/BRD4/PI3K/YAP/PIGF signaling induced angiogenesis.
Li F, Li Y, Hao W, Zhang X, Shen X, Yang B, Zhang W, Fu L, Gu S
PloS one 2026;21(2):e0342649
PloS one 2026;21(2):e0342649
Taohong Siwu Decoction Regulates MSC-Mediated H-Type Angiogenesis to Accelerate Bone Fracture Healing Through VHL/HIF-1α Ubiquitination.
Li W, Ma Z, He P, Xu W, Liu X, Yao J, Wu Q, Zou P, Li T
Mediators of inflammation 2026;2026:6551954
Mediators of inflammation 2026;2026:6551954
Characterization of Gastric Mucinous Carcinoma: Clinicopathological Insights and Vascular Features via MSCT.
Huang Y, Li Q, Li L, Zhang M, Luo Y, Shen Q, Xiao S, Huang Q
International journal of general medicine 2026;19:567353
International journal of general medicine 2026;19:567353
Yizong Tongluo formula attenuates idiopathic pulmonary fibrosis and inflammatory injury by inhibiting HIF-1α/LSH/SCD1-mediated ferroptosis.
Ma X, Wang X, Jiang D, Tuerxun Y, Tao S, Li F, Wei Y, Yang L, Xi L, Wang L
Frontiers in immunology 2026;17:1760615
Frontiers in immunology 2026;17:1760615
Hypoxia‑induced exosomal CAMTA1 promotes radio‑resistance in MDA‑MB‑231 cells by regulating NRG1 to mediate M2 macrophage polarization.
Li Q, Jiang M, Zhu B, Wei W, Xia L, Huang J, Gao H, Du M
International journal of oncology 2026 May;68(5)
International journal of oncology 2026 May;68(5)
Hyaluronic acid-coated Cu/Mn Prussian blue nanocubes amplify cuproptosis and cGAS-STING signaling for synergistic prostate cancer therapy.
Yao X, Ruan Y, Rao T, Lin F, Zhang W
International journal of biological macromolecules 2026 May;362:152036
International journal of biological macromolecules 2026 May;362:152036
YTHDF3 Mediates the Occurrence and Development of Breast Cancer by Regulating Glycolysis Through the mTOR-HIF1α-LHDA Axis.
Liu Z, Jiang T, Li P, Dong K, Wang X, Geng C, Zhang X, Zuo D, Zhao G
Journal of cellular and molecular medicine 2026 May;30(9):e71105
Journal of cellular and molecular medicine 2026 May;30(9):e71105
LINC01116 promotes glycolysis by up-regulating HIF-1α via YBX1-mediated dual mechanism in lung cancer.
Wang X, Li X, Sun R, Zhang S, Jiao T, Lyu X, Zeng L, Yuan B, An X, Zhang C, Ni Z, Yang S
Free radical biology & medicine 2026 May;248:320-332
Free radical biology & medicine 2026 May;248:320-332
Huzhang-Xiangbaji compounds enhance the repair of meniscal cartilage by inhibiting ferroptosis and inflammatory microenvironment.
Li J, Zhou J, Zhang G, Ding N, Kuang Z, Wang J, Liu N, Jia G, Jiang M, Wu S, Yang J, Ding X, Lei Z, Nie Y, Zhang Y, Li Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 May;154:158008
Live and heat-treated Lactiplantibacillus plantarum induce distinct metabolic and immune responses in intestinal epithelial cells.
Matsumoto K, Takada Y, Imamura Y, Yoshida H, Sonomura K, Takahashi M, Moritoki N, Shindo T, Yamamoto J, Albarracin L, Ikeda-Ohtsubo W, Hori M, Villena J, Namai F, Tsujikawa Y, Hashimoto T, Nishiyama K, Kitazawa H
iScience 2026 May 15;29(5):115516
iScience 2026 May 15;29(5):115516
TGM2-mediated serotonylation in tumor endothelial cells promotes angiogenesis and tumor growth in colorectal cancer.
Ling T, Zhang W, Cai H, Kien TT, Yan T, Wang J, Chen J
Cancer letters 2026 May 1;645:218396
Cancer letters 2026 May 1;645:218396
S100B induces angiogenesis via the clathrin/FOXO1/β-catenin signaling pathway and contributes to Bevacizumab resistance in epithelial ovarian cancer.
Xu H, Li W, Yue H, Bai Y, Li J, Lu X, Wang J
Journal of advanced research 2026 Mar;81:613-636
Journal of advanced research 2026 Mar;81:613-636
Magnesium ion implantation enhances the osseointegration and vascularization of 3D-Printed CoCrMo alloy scaffolds for load-bearing orthopedic applications.
Dong Z, Gao C, Wang X, Zhang T, Geng X, Chen J, Feng J, Zheng Y, Zhang Y, Han Z, Wang H, Tan J, Zhang X, Li Y, Li Z, Wei C, Cai Q, Tian H
Bioactive materials 2026 Mar;57:676-693
Bioactive materials 2026 Mar;57:676-693
HIF1A transcriptionally activates CDKN1A to drive ferroptosis in skeletal muscle ischaemia-reperfusion injury.
Zhou M, Wang K, Jin Y, Liu J, Xue Y, Wang Y, Jia X, Liu H, Wang P, Li Z, Pan X, Ma Y, Rui Y
Journal of orthopaedic translation 2026 Mar;57:101055
Journal of orthopaedic translation 2026 Mar;57:101055
MED1 IDR deacetylation controls stress responsive genes through RNA Pol II recruitment.
Lin R, Mo Y, Barrows D, Mei W, Onikubo T, Sun J, Zhang Z, Apostolou E, Tavazoie SF, Roeder RG
Nature chemical biology 2026 Mar;22(3):501-513
Nature chemical biology 2026 Mar;22(3):501-513
AURKA Activates FOXO3a to Form a Positive Feedback Loop in the Proliferation and Migration of Keloid Fibroblasts.
Chu X, Sun J, Dai S, Liang Y, Qian X, Xu J, Zhang J
Advances in wound care 2026 Mar;15(3):168-180
Advances in wound care 2026 Mar;15(3):168-180
Distinct roles of lysophosphatidic acid (LPA) receptor signaling in regulating gastric cancer cell functions under chemical versus physiological hypoxia.
Yashiro N, Yamamoto M, Kusumoto Y, Nagano S, Tamura M, Shimomura N, Takai M, Tsujiuchi T
Acta histochemica 2026 Mar;128(1):152299
Acta histochemica 2026 Mar;128(1):152299
Lactate Metabolism-Immune Regulation-Related Gene Signature in Lower-Grade Gliomas: Prognostic Model Development and Immune Characterization.
Zhang E, Wei L, Ren H, Zhang J, Yang H, Sun M, Gao X, Huang Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71637
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Mar 31;40(6):e71637
Engineered Bacteria-Driven Biohybrid Microrobots Potentiate IL-2 Immunotherapy by Evoking Pyroptosis.
Li P, Li Q, Ding L, Peng S, Wei H, Chen T, Xiong Y, Tang BZ, Huang X
ACS nano 2026 Mar 24;20(11):9407-9427
ACS nano 2026 Mar 24;20(11):9407-9427
Alternations in the expression of hypoxia inducible factor 1 alpha (HIF1α) and selected angiogenesis-related genes in the hen ovary in relation to follicle development and atresia.
Machura MH, Hrabia A
Poultry science 2026 Mar 21;105(6):106839
Poultry science 2026 Mar 21;105(6):106839
USP5-mediated CD73 deubiquitination drives osimertinib resistance via PI3K/AKT and glycolysis activation in LUAD.
Chen R, Han XH, Zhang Z, Han XJ, Xie J
iScience 2026 Mar 20;29(3):114916
iScience 2026 Mar 20;29(3):114916
Hypoxia-triggered dichloroacetate delivery with effective reversal of cancer cell reprogramming.
Sun R, Wang L, Liu Z, Wu H, Wang W, Wang Y, Qian X, Akkaya EU
RSC medicinal chemistry 2026 Mar 2;
RSC medicinal chemistry 2026 Mar 2;
FUT8 reprograms glycolytic metabolism to promote PKM2 lactylation and drive clear cell renal cell carcinoma progression.
Guo Z, Jiang H, Wang X, Xuan K, Zhong H, Liu C, Zhang M, Li Z, Huang W, Sun Y
Cell death discovery 2026 Mar 19;12(1)
Cell death discovery 2026 Mar 19;12(1)
Enhanced HIF-1α cooperation by a human RORγt mutant potentiates Th17 pathogenicity.
Dong P, Liu L, Yu J, Li N, Davidorf B, Shen S, Bouch R, Zhang J, Ho D, Xiao G, Akbari O, Zhang B, He Z
Cell reports 2026 Mar 17;45(4):117123
Cell reports 2026 Mar 17;45(4):117123
O-GlcNAcylation of YAP1 promotes lung transplant ischemia-reperfusion injury via binding to HIF1α transcription factor and activating autophagy and mitophagy.
Dai S, Wan X, Xia L, Xu L, Xie C, Wang G, Tang J
Cell death & disease 2026 Mar 15;17(1)
Cell death & disease 2026 Mar 15;17(1)
GSH-Activated Cu-TCPP(Zn)/Ti(3)C(2)T(x) Nanozymes for Fluorescence Imaging-Guided Synergistic Photodynamic/Chemodynamic Therapy of Oral Squamous Cell Carcinoma.
Wang L, Sun Y, Sun Y, Zhang C, Wang G, He J, Zhao Y, Li M
ACS applied materials & interfaces 2026 Mar 11;18(9):13649-13669
ACS applied materials & interfaces 2026 Mar 11;18(9):13649-13669
Targeting HIF-1α promotes ferroptosis and boosts antitumor immunity in MSS colorectal cancer.
Yang Z, Ma R, Wu W, Shi Y, Chen Y, Luo X, Li K, Wu L, Wang B, Zhang B, Yuan P
Redox biology 2026 Jun;93:104151
Redox biology 2026 Jun;93:104151
Integrated fabrication of a shape-adaptable, antioxidative composite stent for effective closure and biological repair of enteroatmospheric fistula.
Qu G, Li Z, Yang S, Huang L, Liu Y, Li S, Liu J, Yu L, Ma R, Teng Y, Li H, Huang J, Ren J, Wu X
Bioactive materials 2026 Jun;60:55-73
Bioactive materials 2026 Jun;60:55-73
circPLEKHM1 promotes tumor growth and metastasis through enhancing FXR1-mediated protein translation in PDAC.
Yang Y, Li Z, Gao L, Ming Y, Zhang T, Ye Z, Liu W, Xiong Q, Xu X, Xu F, Guo J, Li J, Yang X, Peng Y, Zhu Q
Cancer letters 2026 Jun 1;647:218414
Cancer letters 2026 Jun 1;647:218414
HIF-1α drives pyroptosis in extravillous trophoblasts by suppressing PPAR-γ to activate the NLRP3 inflammasome in RA-complicated pregnancy.
Zhang T, Zhao Y, He W, Chen Y, Liu Q, Tang Y, Geng S, Xu L, Tao L, Yu Z, Zhang X, Yang Y, Zhao J, Zhang L
International immunopharmacology 2026 Jun 1;178:116522
International immunopharmacology 2026 Jun 1;178:116522
Design, synthesis, and biological evaluation of selective cytotoxicity-derived Miliusol derivatives inducing profound TNBC regression in vivo.
Cheng X, Chen W, Hao W, Guo Y, Zhang J, Song C, He Z, Wu H, Yao D
Bioorganic & medicinal chemistry 2026 Jul;138:118680
Bioorganic & medicinal chemistry 2026 Jul;138:118680
GLT8D2-mediated PD-L1 N-glycosylation promotes tumor immune evasion in ovarian cancer peritoneal metastasis.
Xu Y, Huang S, Chen J, Tang Z, Fu Y, Chen Z, Lin Z, Hu J, Zhang W, He S
Cancer letters 2026 Jul 10;650:218478
Cancer letters 2026 Jul 10;650:218478
Poly-ADP-ribosylation modulated by poly(ADP-ribose) polymerase 1 is associated with glucose metabolism in colorectal cancer cells.
Zhang C, Wang P, Yu J, Yuan J, Zhang L, Li M
Translational oncology 2026 Jan;63:102623
Translational oncology 2026 Jan;63:102623
Suppression of HIF-1α alleviates the symptoms associated with diabetic retinopathy in mice.
Wang J, Fang S, Wang J, Liu W, Meng F, Zhou X, Gao L
Experimental eye research 2026 Jan;262:110741
Experimental eye research 2026 Jan;262:110741
NAT10-mediated ac4C modifications regulate glioblastoma progression.
Lin L, Xiong Y, Guo Y, Tu Z, Luo P, Fang Z, Zhang L, Huang K, Wu L
Cell death & disease 2026 Jan 8;17(1):181
Cell death & disease 2026 Jan 8;17(1):181
Transcriptional mechanisms of hearing acclimatization to high altitude in rats.
Awang D, Danzeng K, Ren H, Da Z, Gesang Q, Deji Q, Xie H, Liu X, Zhao B, Gongga L
Scientific reports 2026 Jan 5;16(1):4223
Scientific reports 2026 Jan 5;16(1):4223
Dictamnine inhibited keratinocyte hyperproliferation and alleviated psoriasis-like dermatitis via blocking HIF1A-mediated ferroptotic pathway.
Wang W, Zhang J, Jiang SL, Rao ZM, Liu H, Wang L, Cai CL, Xu XC, Yu CH, Wang W
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120607
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120607
Network pharmacology approach and experimental validation of Lamei pills in treating ischemic stroke based on UHPLC-QE-MS.
Li C, Liu C, Xia Y, Liu X, Wang F, Zhuo G, Ren Q
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120578
Cell-free mitochondrial DNA as a potential predictor for hypoxic stress.
Qu Q, Xiao C, Liu X, Huang A, Li H, Xu G, Shao N, Zhao Y, Gao B
Molecular biology reports 2026 Jan 3;53(1):253
Molecular biology reports 2026 Jan 3;53(1):253
Targeting endolysosomal acidification inhibits poxvirus entry and replication.
Xu S, Zhang X, Li C, Zhang Z, Wang X, Wan C, Wang P, Lv Y, He Y, Chan FK, Liu Z
Cell communication and signaling : CCS 2026 Jan 28;24(1)
Cell communication and signaling : CCS 2026 Jan 28;24(1)
Hypoxic glycolysis-driven histone lactylation activates NHE7 to promote endometrial cancer progression via COX6C-mediated endoplasmic reticulum stress.
Yang S, Wu T, Cao Z, Chen Z, Ma Y, Wang T, Qian L, Huang X
Apoptosis : an international journal on programmed cell death 2026 Jan 23;31(2):55
Apoptosis : an international journal on programmed cell death 2026 Jan 23;31(2):55
Catalase inhibits tumor growth by alleviating oxidative stress and promoting the polarization of tumor-associated macrophage from M2 to M1 phenotype in non-small cell lung cancer.
Tian Y, Liu YR, Jin HZ, Lin QX, Zhao WY, Song WW, Gong YN, Deng YT, Wang SS, Wang K, Tian L, Gu DN
Biology direct 2026 Jan 23;21(1):24
Biology direct 2026 Jan 23;21(1):24
A P4HA2 hypoxia signature derived from single cell atlas stratifies conserved subtypes with prognostic significance in cervical squamous cell carcinoma.
Li X, Zhang X, Dai Y, Huang F, Wei R, Huang X, Ma D, Li F, Li X
BMC cancer 2026 Jan 21;26(1):257
BMC cancer 2026 Jan 21;26(1):257
Hypoxia-induced PRMT6 expression promotes temozolomide chemoresistance in glioblastoma via G3BP1.
Chen S, Yu P, Sun Y, Yan Y, Zhang B, Li G
Journal of translational medicine 2026 Jan 2;24(1):226
Journal of translational medicine 2026 Jan 2;24(1):226
Shen-Shuai-II-Recipe inhibits aerobic glycolysis through SIRT1 in 5/6 ablation/infarction renal failure model.
Lan T, Zhang X, Lyu X, Wu M, Wang C, Yang L
Scientific reports 2026 Jan 11;16(1):5022
Scientific reports 2026 Jan 11;16(1):5022
ALYREF expression correlated with upregulated YBX1 and HIF1α, contributing to cell migration in gastric cancer.
Yuan Y, Qiu J, Tang W, Shen X, Sun H, Shu S, Wang Q, Fan H
Tissue & cell 2026 Feb;98:103210
Tissue & cell 2026 Feb;98:103210
USP3 stabilizes MIC19 by deubiquitination under hypoxic stress and promotes the progression of non-small cell lung cancer.
Zhao WH, Huang H, Ding C, Zhao ZX, Jia CY, Wang YJ, Hu ZX, Wang GN, Li YW, Liu JH, Liu HY, Chen J
Acta pharmacologica Sinica 2026 Feb;47(2):391-403
Acta pharmacologica Sinica 2026 Feb;47(2):391-403
Protein tyrosine kinase Src suppresses hepatitis C virus particle release through regulation of Ndrg1.
Fu L, Takeuchi K, Chihara K, Feng W, Sada K
The Journal of biological chemistry 2026 Feb;302(2):111125
The Journal of biological chemistry 2026 Feb;302(2):111125
Mechanisms of resistance to VHL loss-induced genetic and pharmacological vulnerabilities.
Ge J, Hirosue S, Castillon L, Patel SA, Wesolowski L, Dyas A, Yong C, de Haan S, Drost J, Stewart GD, Obenauf AC, Muñoz-Espín D, Vanharanta S
EMBO molecular medicine 2026 Feb;18(2):599-619
EMBO molecular medicine 2026 Feb;18(2):599-619
Engineered Gadolinium-Decorated Magnetic Resonance Nanoprobes for Enhanced Liver Fibrosis Theranostics.
Wang Y, Zhang Q, Yan B, Pang L, Ren Y, Inam M, Zhang M, Ni N, Xu X, Sun X, Zhou S
Advanced healthcare materials 2026 Feb;15(8):e03891
Advanced healthcare materials 2026 Feb;15(8):e03891
SERPINE1-Driven MAPK Activation Enhances Cuproptosis Resistance and Angiogenic Potential in Colorectal Cancer.
Gao P, Li H, Luo J, Zhang C, Wei J, Li X, Ma H
Digestive diseases and sciences 2026 Feb 9;
Digestive diseases and sciences 2026 Feb 9;
DCC-2036 induces repolarization of TAMs to M1 type and enhances CD8(+) T cell immunity in TNBC.
Liang Y, Zeng Q, Xiao M, Li P, He R, Chen Z, Liu J, Cao J, Li J, Yin L, Zhong J, Chen X, Feng J, He J, Chen X, Zu X, Shen Y
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):985-1008
Molecular therapy : the journal of the American Society of Gene Therapy 2026 Feb 4;34(2):985-1008
Integrated multi-omics analysis reveals GPD1L-mediated dysregulation of glycerophospholipid metabolism facilitates the progression of lung adenocarcinoma.
Sun Y, Yan Y, Zhou Y, Chen Y, Liu C, Bao Y, Zhang Y, Han H, Chen H
Respiratory research 2026 Feb 14;27(1):86
Respiratory research 2026 Feb 14;27(1):86
Asporin regulates glycolysis and stemness of gastric cancer cells.
Xu G, Cai Z, Zhuang Y, Wang H, Lin Q, Guo T, Tao H
Journal of molecular histology 2026 Feb 13;57(2):74
Journal of molecular histology 2026 Feb 13;57(2):74
Vascular normalization by erianin unleashes CAR-T immunotherapy in glioblastoma.
Zhou S, Qian S, Sun B, Shi P, Guo S, Yang C, Zhang J, Gong Y, Yang F
Angiogenesis 2026 Feb 12;29(2):18
Angiogenesis 2026 Feb 12;29(2):18
Endogenous H₂S promotes HSPA8 sulfhydration to downregulate HIF1α and prevent ferroptosis in septic myocardial injury.
Jiankui D, Zhang S, Li Z, Li W, Weina L, Miao W, Jian X, Changnan W
Redox report : communications in free radical research 2026 Dec;31(1):2626159
Redox report : communications in free radical research 2026 Dec;31(1):2626159
Modified Erxian Decoction ameliorates premature ovarian insufficiency via HIF-1α-mediated regulation of mitochondrial fission and oxidative stress.
Deng D, Zeng Z, Feng J, Guo J
Journal of ethnopharmacology 2026 Aug 10;367:121768
Journal of ethnopharmacology 2026 Aug 10;367:121768
Frehmaglutin F and frehmaglutin H ameliorate hypoxy-induced PASMCs injury via SIRT3/HIF-1α/PKM2 signal pathway.
Zhang Y, Zeng M, Guo P, Zhang Z, Chen X, Li X, Lian Z, Feng W, Zheng X
Cytotechnology 2026 Apr;78(2):48
Cytotechnology 2026 Apr;78(2):48
Tanshinone IIA attenuates airway inflammation and airway remodeling in bronchial asthma by inhibiting p38/NF-κB and AKT/HIF-1α.
Yu W, Peng Z, Lü B, Yu Y, Chen J
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Apr;63(4):428-438
The Journal of asthma : official journal of the Association for the Care of Asthma 2026 Apr;63(4):428-438
Macrophage CBX4 Potentiates Atherosclerosis by its SUMO E3 Ligase Activity.
Zhao Z, Xu S, Ma J, Zhang Z, Liang S, Guo J
Cardiovascular drugs and therapy 2026 Apr;40(2):447-460
Cardiovascular drugs and therapy 2026 Apr;40(2):447-460
Mitotic spindle-organizing protein 2A (MZT2A) promotes cisplatin resistance through NEMO ubiquitination and NF-κB activation in lung adenocarcinoma.
Wang H, Zhang Z, Li Y, Li S, Guan J, Liu Z, Ma Y, Yang X
The Journal of biological chemistry 2026 Apr;302(4):111330
The Journal of biological chemistry 2026 Apr;302(4):111330
Interfacial Bioengineering of Dynamic Networks Hybrid Hydrogel for Programmed Intervention in Oral Precancerous Epithelial States.
Zhao X, Zheng A, Zhao Z, Li Q, Wan T, Deng T, Zhang Y, Cao L, Wu L
Advanced healthcare materials 2026 Apr;15(13):e04229
Advanced healthcare materials 2026 Apr;15(13):e04229
CircRSU1 Activates the hnRNPA1/HIF-1α/CD24 Signaling Axis, Promoting Stemness Features of Hepatocellular Carcinoma.
Xue S, Wei D, Zhao Y, Pan J, Zhang H, Liu N, Zhang J, Liu J, Jin J, Xiao M, Feng X, Lin A, Zhao L, Roessler S, Ji J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e22424
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Apr;13(22):e22424
Taurine stimulates EPO production in feline renal cells through the HIF pathway.
Li J, Ma Y, Gao Y, Xu Y, Lv L
Scientific reports 2026 Apr 9;
Scientific reports 2026 Apr 9;
MiR-93-5p Loaded Lipid Nanoparticles Break the Dry Eye Vicious Cycle via Targeting MAP3K8.
Xu B, Ji X, Li L, Zhu L, Wang L, Kang J, Yang S, Fan T
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
ACS applied materials & interfaces 2026 Apr 8;18(13):18740-18754
Triptolide alleviates pathological neovascularisation in oxygen-induced retinopathy via inhibiting the inflammation mediated by NF-κB pathway.
Liu X, Zhao C, Yang H, Huang J, Zhou Q, Zhang Z, Li X, Yang P, Hou S
The British journal of ophthalmology 2026 Apr 22;110(5):527-535
The British journal of ophthalmology 2026 Apr 22;110(5):527-535
LUCAT1/PTBP1/HIF-1α feedback loop promotes T cell over-differentiation and Th1/Th2-skewed immune imbalance in sepsis via glucose metabolism.
Gao W, Zhang H, Fan J, Wu L, Liu W
Cytokine 2026 Apr 21;203:157157
Cytokine 2026 Apr 21;203:157157
Hypofractionated radiotherapy followed by rhGM-CSF enhances immunogenic cell death in a murine model of pancreatic cancer.
Tang J, Chen F, Xia H, Wang C, Tang R, Luo S
Acta cirurgica brasileira 2025;40:e407625
Acta cirurgica brasileira 2025;40:e407625
Nucleolin-Targeted DNA Nanoflowers Enable Multimodal Synergistic Cancer Therapy.
Ren A, Liu H, Tang Z, Zheng P, Hu Q, Huang T
Biomaterials research 2025;29:0254
Biomaterials research 2025;29:0254
Roxadustat: A catalyst for diabetic wound healing through re-epithelialization and angiogenesis.
Tang D, Lin Q, Xu K, Lu QP
CytoJournal 2025;22:90
CytoJournal 2025;22:90
Withaferin-A inhibits colorectal cancer growth and metastasis by targeting the HSP90/HIF-1α/EMT axis.
Lu WQ, Li XD, Gu Y, Huang JM, Qin YK, Cai XY, Wang CM
Archives of medical science : AMS 2025;21(4):1487-1501
Archives of medical science : AMS 2025;21(4):1487-1501
Mechanistic Insights Into Qidan Yixin Decoction for Diabetic Cardiomyopathy via Macrophage Polarization.
Liu Y, Zhang J, Gao W, Han Q, Xue Y, Liu X
Journal of diabetes research 2025;2025:7578626
Journal of diabetes research 2025;2025:7578626
Protective effect of Pinacidil on hypoxic-reoxygenated cardiomyocytes in vitro and in vivo via HIF-1α/HRE pathway.
Wang Y, Wang J, Chen L, Zhou W, He H, Chen X, Wang H
PloS one 2025;20(2):e0318859
PloS one 2025;20(2):e0318859
Enhanced Antitumor Efficacy and Reduced Toxicity in Colorectal Cancer Using a Novel Multifunctional Rg3- Targeting Nanosystem Encapsulated with Oxaliplatin and Calcium Peroxide.
Xie Y, Zhu M, Bao H, Chen K, Wang S, Dai J, Chen H, Li H, Song Q, Wang X, Yu L, Pei J
International journal of nanomedicine 2025;20:1021-1046
International journal of nanomedicine 2025;20:1021-1046
Mechanistic Insights into Shenzhuo Formula for Diabetic Retinopathy: Integrating UPLC-Q-TOF-MS/MS, Network Pharmacology, Single-Cell RNA Sequencing Data, and Experimental Validation.
Zang X, Zhang L, Ma J, Wang A, Ding L, Wang Y, Sun J, Li J, Hang X, Li X, Zhao L
Drug design, development and therapy 2025;19:6183-6205
Drug design, development and therapy 2025;19:6183-6205
PEDF Alleviates Diabetic Renal Fibrosis by Degrading Kidney Ectopic Fat Deposition and Inhibiting Metabolic Reprogramming of Renal Tubular Epithelial Cells.
Mao T, Bi Y, Bao Y
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4211-4227
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:4211-4227
The molecular mechanism underlying angiogenesis in a mouse model of chronic kidney disease after ischemic stroke.
Wang F, Lu L, Feng J, Zheng J, Wei Z, Wang Z
American journal of translational research 2025;17(1):528-537
American journal of translational research 2025;17(1):528-537
Hypoxia upregulate TPM4 expression to strengthen epithelial-mesenchymal transition that promotes lymph node metastasis of papillary thyroid cancer.
Li Z, Li F, Jiang X, Li Y, Jia L, Wang X, Liu Y, Jiang R, Zhao K, Pu G, Tian Y, Wang Y, He X
Journal of Cancer 2025;16(10):3216-3234
Journal of Cancer 2025;16(10):3216-3234
GDF15 orchestrates mitochondrial-immune crosstalk via SMAD7-HIF-1α-PKM2 cascade to attenuate septic liver injury.
Kuang X, Niu Z, Liu W, Huang Z, Li S, Zhang Y, Wang L, Cai X, Wang F, Zhang P
Frontiers in immunology 2025;16:1712741
Frontiers in immunology 2025;16:1712741
HuangLian-4 alleviates myocardial ischemia-reperfusion injury by activating the pro-survival STAT3 signaling pathway.
Gong C, Wang D, Zhang Q
Frontiers in pharmacology 2025;16:1683575
Frontiers in pharmacology 2025;16:1683575
Fucoidan from Fucus vesiculosus alleviates MetALD via promoting HIF-1α ubiquitination to suppress peripheral monocyte infiltration.
Li L, Luo J, Wang D, Chang Y, Duan C, Zuo D
Frontiers in pharmacology 2025;16:1617175
Frontiers in pharmacology 2025;16:1617175
Macrophage PKM2 depletion ameliorates hepatic inflammation and acute liver injury in mice.
Kang Z, Xie R, Cui Y, Chen Z, Li J, Lv J, Ye W, Zhao P, Zhang K, Hong J, Qu H
Frontiers in pharmacology 2025;16:1546045
Frontiers in pharmacology 2025;16:1546045
Exploring the multi-targeted mechanism of Saikosaponin A in prostate cancer treatment: a network pharmacology and molecular docking approach.
Zhu G, Jiang Z, Zhu N, Wang D, Guo T, Meng Y, Zhu Y, Tan K, Hu M, Tang H, Wang X
Frontiers in pharmacology 2025;16:1530715
Frontiers in pharmacology 2025;16:1530715
Regulatory mechanism of ABCB1 transcriptional repression by HDAC5 in rat hepatocytes under hypoxic environment.
Wei Z, Mu H, Qiu F, Zhao M, Zhang X, Li W, Jia H, Wang R
Frontiers in physiology 2025;16:1520246
Frontiers in physiology 2025;16:1520246
Saikosaponin D Mitigates Radioresistance in Triple-Negative Breast Cancer by Inducing MRE11 De-Lactylation via HIF1α/HDAC5 Pathway.
Li J, Feng L, Zhang L, Zhang W, Zhang Y, Liu X, Cai Q, Zhao W, Huang G, Lu C
Theranostics 2025;15(17):8935-8951
Theranostics 2025;15(17):8935-8951
Characterization of hypoxia-related molecular clusters and prognostic riskScore for glioma.
Fang X, Wu X, Xu C
Frontiers in oncology 2025;15:1605949
Frontiers in oncology 2025;15:1605949
Roxadustat regulates the cell cycle and inhibits proliferation of mesangial cells via the hypoxia-inducible factor-1α/P53/P21 pathway.
Cheng Y, Yang Q, Feng B, Yang X, Jin H
Frontiers in cell and developmental biology 2025;13:1503477
Frontiers in cell and developmental biology 2025;13:1503477
Yishen-Huoxue formula alleviates renal interstitial fibrosis by attenuating hypoxia-induced renal cell injury and promoting angiogenesis via miR-210/HIF-1α pathway.
Du M, Yao C, Lv Q, Gong A, Zhu Y, Li J, Zhong J
Frontiers in medicine 2025;10:1530092
Frontiers in medicine 2025;10:1530092
Daughter Cells Budding From PGCCs and Their Clinicopathological Significances in Oral Squamous Cell Carcinoma.
Zhuo S, Jing C, Liu X, Yue J, Zhang W, Zhang S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Sep;54(8):687-693
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2025 Sep;54(8):687-693
Microplastic exposure induces preeclampsia-like symptoms via HIF-1α/TFRC-mediated ferroptosis in placental trophoblast cells.
Jia H, Liu S, Wang W, He P, Zhao F, Xu X
Toxicology 2025 Sep;516:154197
Toxicology 2025 Sep;516:154197
Discovery of Baicalein as a Novel Ubiquitin-Specific Protease 21 Inhibitor for the Treatment of Hepatocellular Carcinoma.
Jia H, Zhao Z, Su C, Du J, Yang S, Song J, Han X, Yu F, Sun Z, Chu P
Phytotherapy research : PTR 2025 Sep;39(9):3935-3951
Phytotherapy research : PTR 2025 Sep;39(9):3935-3951
Regulation of macrophage phenotypes via NF-κB/NLRP3 and HIF1α/p53 pathways by fuco-galactoglucan from Agrocybe aegerita.
Li X, Shui M, Zhang X, Tang H, Guo H, Gu F, Xu H, Han B, Kou Y
International journal of biological macromolecules 2025 Sep;322(Pt 2):146559
International journal of biological macromolecules 2025 Sep;322(Pt 2):146559
KDM4C regulates trophoblast proliferation and migration in preeclampsia via the NFATc4/Wnt pathway.
Shao C, Jia Y, Qiao S, Gao Q, He T, Meng Y, He J, Shan Y
International journal of biological macromolecules 2025 Sep;321(Pt 3):146320
International journal of biological macromolecules 2025 Sep;321(Pt 3):146320
LncRNA H19 and miR-138 modulate retinal neovascularization and associated pathological features in hypoxia-induced disease models.
Yu Y, Di Y, Li P, Nie Q, Chen X, Wang A, Ren K
Experimental eye research 2025 Sep;258:110512
Experimental eye research 2025 Sep;258:110512
p67phox/NOX2 inhibits psoriasis by regulating the HIF-1α-glycolysis axis via p53-AMPK in keratinocytes.
Li A, Zhuang Z, Xia Q, Zhou X, Yang J, Liu B, Huang X, Xue K, Song X, Xu J, Cui Y
Free radical biology & medicine 2025 Sep;237:503-514
Free radical biology & medicine 2025 Sep;237:503-514
Phytochemistry analysis of the above-ground parts of Sanguisorba officinalis L. and its effects on myocardial cell metabolism.
Zhang B, Zhang Q, Liu Z, Zhai Y, Jin P, Luan H
Fitoterapia 2025 Sep;185:106686
Fitoterapia 2025 Sep;185:106686
Neuroprotective effects of Rosavin via HIF-1α signaling in a rat model of ischemic stroke.
Lai W, Nie J, Hong A, Zhang Y, Chen J, Zheng X, Wang Y, Zhang X, Chen J, Hong G
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157068
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157068
Glioblastoma exploits ATP from leading-edge astrocytes to fuel its infiltrative growth revealed by spatially resolved chimeric analysis.
Yang G, Niu X, Gan J, Yu T, Li M, Xiao P, Zhang R, He P, Yang Y, Cui Y, Huang X, Wang Y, Mao Q, Zhou R
Science advances 2025 Sep 26;11(39):eadv5673
Science advances 2025 Sep 26;11(39):eadv5673
Echinacoside targets the HIF-1α/LDHA axis to modulate A1/A2 astrocyte differentiation and promote glial scar repair following ischemic stroke.
Liao Y, Yang L, Guo C, Hu J, Wen L, Ju B, Hou Q, Zhu H, Ding Y, Yang J, Zhao M
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120375
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120375
Propionate alleviated colitis by modulating iron homeostasis to inhibit ferroptosis and macrophage polarization.
Yao T, Dong X, Lv J, Fu L, Li L
International immunopharmacology 2025 Sep 23;162:115151
International immunopharmacology 2025 Sep 23;162:115151
Identification of autophagy-related biomarkers in the circulatory system of ischemic stroke.
Xu Y, Duan J, Zhong D, Yuan M, Zhang G, Zhu Z, Xie Y
Neurological research 2025 Sep 2;:1-18
Neurological research 2025 Sep 2;:1-18
Glucose-Fueled Histone Modifications Drive HIV-1 Latency Reversal at Hypoxia.
Kayode YI, Clemmer DC, Owolabi AA, AlShaheeb AA, McMahon EK, Tangiyan A, Clark L, Simmons GE, Bosque A, McReynolds MR, Taylor HE
bioRxiv : the preprint server for biology 2025 Sep 16;
bioRxiv : the preprint server for biology 2025 Sep 16;
Rapamycin suppresses small bowel adenocarcinoma HUTU 80 cells proliferation by inhibiting hypoxia-inducible factor-1α mediated metabolic reprogramming.
Pu BP, Wang PH, Guo KK, Liu C, Chen SR, Li XM, Chen SM, Zeng XZ, Gao C
World journal of gastrointestinal oncology 2025 Sep 15;17(9):109378
World journal of gastrointestinal oncology 2025 Sep 15;17(9):109378
Curcumin inhibits aortic dissection progression: Insights from the integrated analysis of network pharmacology, gut microbiota, and serum metabolomics.
Liu S, Cheng S, Shan J, Xia L, Li Z
Biochemical and biophysical research communications 2025 Sep 1;777:152281
Biochemical and biophysical research communications 2025 Sep 1;777:152281
YY1-induced USP43 drives ferroptosis suppression by FASN stabilization and subsequent activation of SLC7A11 in ovarian cancer.
Zhao T, Chen X, Wu J, Chen S, Gan Y, Liu C, Ha X, Wu Y, Zhou X, Wu Y, Wu X
Cell death & disease 2025 Sep 1;16(1):589
Cell death & disease 2025 Sep 1;16(1):589
Targeting Ferroptosis Alleviates Pulmonary Arterial Hypertension, Insights from Transcriptomic and Experimental Analyses.
Wang X, Guo Q
Advanced biology 2025 Oct;9(10):e00001
Advanced biology 2025 Oct;9(10):e00001
KIF4A Promotes Glioblastoma Malignant Progression and Transmission of Temozolomide Resistance in the Tumor Microenvironment via the HIF1A/VEGFA Axis.
Shen X, Cheng H, Xia Y, Zheng J, Peng Q, Zhang Z, Yin N, Liu Y, Dong J, Shen Y
CNS neuroscience & therapeutics 2025 Oct;31(10):e70550
CNS neuroscience & therapeutics 2025 Oct;31(10):e70550
The oncogenic role of CCDC34 in lower-grade gliomas: prognostic significance and therapeutic potential.
Shen H, Li J, Jia Y, Liu F
Journal of neuro-oncology 2025 Oct;175(1):71-89
Journal of neuro-oncology 2025 Oct;175(1):71-89
A Novel Injectable Composite Hydrogel HAp-GelMA Co-Doped Magnesium/Zinc Promotes Bone Generation and Angiogenesis Synergistically.
Qiang L, Zhang T, Zhang Q, Yang T, Shan J, Shen G, Kong W, Wei J, Wang J, Liu Y, Niu H, Zheng P
Advanced healthcare materials 2025 Oct;14(27):e01008
Advanced healthcare materials 2025 Oct;14(27):e01008
Harpagide Confers Protection Against Acute Lung Injury Through Multi-Omics Dissection of Immune-Microenvironmental Crosstalk and Convergent Therapeutic Mechanisms.
Wang H, Yang J, Zhang Y, Wang J, Song S, Gao L, Liu M, Chen Z, Li X
Pharmaceuticals (Basel, Switzerland) 2025 Oct 4;18(10)
Pharmaceuticals (Basel, Switzerland) 2025 Oct 4;18(10)
Rutin alleviates preoperative anxiety stress-induced persistent postoperative pain by inhibiting microglia-mediated abnormal synaptic engulfment in the spinal cord dorsal horn.
Zhang Y, Yang H, Zhao Y, Ni K, Sun J, Ma Z
International immunopharmacology 2025 Oct 30;164:115309
International immunopharmacology 2025 Oct 30;164:115309
Molecules interacting with CasL-Like 2 enhances tumor angiogenesis and progression by activating mTOR/HIF1α/VEGF pathway in kidney renal clear cell carcinoma.
Song Y, Zhang J, Liu G, Jiang X, Sun N, He H, Song S, Wang W
Scientific reports 2025 Oct 21;15(1):36581
Scientific reports 2025 Oct 21;15(1):36581
Mechanism of retinal angiogenesis induced by HIF-1α and HIF-2α under hyperoxic conditions.
Feng X, Li C, Zhang W, Jiao K, Zhang L, Xiao L
Scientific reports 2025 Oct 15;15(1):36049
Scientific reports 2025 Oct 15;15(1):36049
Mitochondrial ribosomal protein L12 mediates metabolic reorganization in clear cell renal cell carcinoma by regulating mitochondrial biosynthesis.
Sun S, Su D, Dong T, Wang B, Ji X, Chu L, Lu S, Zhang T, Sun X, Liu Y, Wan Q
Cell communication and signaling : CCS 2025 Oct 14;23(1):435
Cell communication and signaling : CCS 2025 Oct 14;23(1):435
GDF15 attenuates sepsis-induced acute lung injury by suppressing the HIF-1α/LDHA pathway.
Kuang X, Niu Z, Huang Z, Cai X, Wang L, Zhang Y, Luo J, Zhao X, Shuo L, Zhang P
International immunopharmacology 2025 Oct 10;163:115198
International immunopharmacology 2025 Oct 10;163:115198
Low Wall Shear Stress Promotes Atheroma via Arterial Iron Accumulation.
Zheng L, Zhang Z, Liu Y, Cheng C, Zhao B, Ji R, Chen Z, Yang L, Cai J, Li K, Qiao T
Arteriosclerosis, thrombosis, and vascular biology 2025 Nov;45(11):1983-1996
Arteriosclerosis, thrombosis, and vascular biology 2025 Nov;45(11):1983-1996
Baicalin promotes anti-tumor immunity in hepatocellular carcinoma through HIF-1α/Lactate/CXCL9 axis.
Yang X, Chen W, Sun H, He C, Liu Y, Qin M, Jiang W, Wang Y, He S
Biochemical pharmacology 2025 Nov;241:117157
Biochemical pharmacology 2025 Nov;241:117157
Glabridin-Gold(I) Complex as a Novel Immunomodulatory Agent Targeting TrxR and MAPK Pathways for Synergistic Enhancement of Antitumor Immunity.
Wang Z, Wang M, Chen Q, Wang M, Li F, Lv L, Wen Z, Xu Z, Yang Y, Bi C, Liu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04729
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Nov;12(41):e04729
Osteocyte Neuropeptide Y Aggravates Bone Loss in OVX Mice by Inhibiting Preosteoclast Proliferation and PDGF-BB-Induced Type H Vessel Formation Through PI3K/Akt Signaling Pathway.
Chen Q, Zhang Y
Calcified tissue international 2025 Nov 4;116(1):134
Calcified tissue international 2025 Nov 4;116(1):134
Targeting CircNLRP12 attenuates hypoxia-induced pulmonary arterial smooth muscle cell dysfunction by sponging miR-107-5p and suppressing the ITGA2-mediated FAK/PI3K/AKT pathway.
Li Z, Zhao M, Ma S, Lei S
European journal of medical research 2025 Nov 27;30(1):1292
European journal of medical research 2025 Nov 27;30(1):1292
Epigenetic regulation of ACSL4 via H2A monoubiquitylation connects lipid metabolism to BAP1-mediated ferroptosis.
Fan K, Zhou S, Ren Y, Xiong J, Wang H, Fu Y, Chen Y, Wang B, Fan K, Gao M, Guo T, Wei X, Jiao L, Shi J, Ding C, Zhang Y
Cell death and differentiation 2025 Nov 27;
Cell death and differentiation 2025 Nov 27;
Lineage plasticity and signal dysregulation define the cellular trajectory of osteoarthritis progression.
Chen G, Tai K, Dai G
Clinical and experimental medicine 2025 Nov 25;26(1):41
Clinical and experimental medicine 2025 Nov 25;26(1):41
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hu HM, Deng JL, Pan Y, Wang ZH, Zhang J, Yu Gu X, Fan SX, Zhao JZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
PFKFB4 promotes endometrial cancer by regulating glycolysis through SRC‑3 phosphorylation.
Wu Y, Zhao J, Zhao S, Li J, Luo J, Wang Y
Oncology reports 2025 May;53(5)
Oncology reports 2025 May;53(5)
Divalent metal ions enhance bone regeneration through modulation of nervous systems and metabolic pathways.
Luo Y, Liu B, Qiu Y, Li L, Yang F, Zhang C, Wang J
Bioactive materials 2025 May;47:432-447
Bioactive materials 2025 May;47:432-447
Astragalin alleviates lipopolysaccharide-induced depressive-like behavior in mice by preserving blood-brain barrier integrity and suppressing neuroinflammation.
Cao MM, Guo Z, Wang J, Ma HY, Qin XY, Hu Y, Lan R
Free radical biology & medicine 2025 May;232:340-352
Free radical biology & medicine 2025 May;232:340-352
Enhancing temozolomide efficacy in GBM: The synergistic role of chuanxiong rhizoma essential oil.
Ke G, Hu P, Xiong H, Zhang J, Xu H, Xiao C, Liu Y, Cao M, Zheng Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156575
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 May;140:156575
Transcriptome Landscape of Cancer-Associated Fibroblasts in Human PDAC.
Tao M, Liu W, Chen J, Liu R, Zou J, Yu B, Wang C, Huang M, Chen Q, Zhang Z, Chen Z, Sun H, Zhou C, Tan S, Zheng Y, Wang H
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2415196
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(20):e2415196
The biomarker potential of circPOLD1 and its binding protein YBX1 in cervical carcinogenesis.
Zhao L, Chen X, Zhang Y, Cen Y, Zhu T, Wang L, Xia L, Li Y, Cheng X, Xie X, Lu W, Xu J
Journal of translational medicine 2025 May 4;23(1):506
Journal of translational medicine 2025 May 4;23(1):506
The key regulator circPDE3B promotes arsenic-induced bladder carcinogenesis by affecting STAT3 and NF-κB stability.
Gao Y, Xu H, Zhao Q, Cai D, Zhou X, Chen X, Yuan S, Li D, Ning T, Dong X, Li M, Li G, Nan A
Cell biology and toxicology 2025 May 28;41(1):91
Cell biology and toxicology 2025 May 28;41(1):91
Hypoxia-inducible factor-1 alpha (HIF-1α) inhibitor AMSP-30 m attenuates CCl(4)-induced liver fibrosis in mice by inhibiting the sonic hedgehog pathway.
Lu L, Ma Y, Tao Q, Xie J, Liu X, Wu Y, Zhang Y, Xie X, Liu M, Jin Y
Chemico-biological interactions 2025 May 25;413:111480
Chemico-biological interactions 2025 May 25;413:111480
Exosomal PD-L1 derived from hypoxia nasopharyngeal carcinoma cell exacerbates CD8(+) T cell suppression by promoting PD-L1 upregulation in macrophages.
Yuan X, Liu X, Jiang D, Zheng Z, Ma X, Wu S, Li X, Lu J, Fu M
Cancer immunology, immunotherapy : CII 2025 May 24;74(7):220
Cancer immunology, immunotherapy : CII 2025 May 24;74(7):220
SRSF1-mediated alternative splicing regulates bladder cancer progression and cisplatin sensitivity through HIF1A/BNIP3/mitophagy axis.
Wu Q, Yu H, Sun H, Lv J, Zhuang J, Cai L, Jiang L, Chen Y, Tao Y, Bai K, Yang H, Yang X, Lu Q
Journal of translational medicine 2025 May 22;23(1):571
Journal of translational medicine 2025 May 22;23(1):571
Edaravone dexborneol provides neuroprotective benefits by suppressing ferroptosis in experimental intracerebral hemorrhage.
Li H, Li X, Li M, Li W, Wei J, Huang Y, Yan H, Lin J, Zhang P
Scientific reports 2025 May 13;15(1):16595
Scientific reports 2025 May 13;15(1):16595
CPT1A/HIF-1α positive feedback loop induced fatty acid oxidation metabolic pathway contributes to the L-ascorbic acid-driven angiogenesis in breast cancer.
Ma X, Zhang B, Yin X, Yang S, Lin Z, Yang Y, Zhou X
Breast cancer research : BCR 2025 May 12;27(1):74
Breast cancer research : BCR 2025 May 12;27(1):74
Baicalin prevents experimental autoimmune uveitis by promoting macrophage polarization balance through inhibiting the HIF-1α signaling pathway.
Liu B, Peng Y, Wang C, Wei H, Xu S, Liu Y, Yin X, Bi H, Guo D
Scientific reports 2025 May 12;15(1):16424
Scientific reports 2025 May 12;15(1):16424
Hsp90 and HIF-1α regulate mitophagy by promoting BNIP3 expression in renal ischemia-reperfusion injury.
Dong Q, Li X, Cheng K
Transplant immunology 2025 Mar;89:102177
Transplant immunology 2025 Mar;89:102177
Hypoxia-inducible factor-1α inhibitor promotes non-alcoholic steatohepatitis development and increases hepatocellular lipid accumulation via TSKU upregulation.
Zeng R, Wang Y, Wen J, Cen Z, Wang T, Duan M, Huang X, Zhao Z, Zhang Z, Yang C, Chen S
Archives of biochemistry and biophysics 2025 Mar;765:110313
Archives of biochemistry and biophysics 2025 Mar;765:110313
Knockdown of SESN2 Exacerbates Cerebral Ischemia-Reperfusion Injury Through Enhancing Glycolysis via the mTOR/HIF-1α Pathway.
Wang Z, Huang Y, Zhang Y, Zhu H, Amin MR, Chen R, Gu L, Xiong X
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314
CNS neuroscience & therapeutics 2025 Mar;31(3):e70314
Adrenomedullin Inhibits the Efficacy of Combined Immunotherapy and Targeted Therapy in Biliary Tract Cancer by Disrupting Endothelial Cell Functions.
Xuan Z, Hu H, Xu J, Ling X, Zhang L, Li W, Li J, Zhu C, Song Y, Zhang X, Rao J, Wang Y, Cheng F
Journal of cellular and molecular medicine 2025 Mar;29(5):e70460
Journal of cellular and molecular medicine 2025 Mar;29(5):e70460
Ultrasound-Triggered Oxygen Release System for Accelerating Wound Healing of Diabetic Foot Ulcers.
Zhuge D, Yang S, Pan X, Xiao Y, Wang X, Wang W, Gao W, Lu A, Shi B, Chen B, Zhao Y
Advanced healthcare materials 2025 Mar;14(6):e2403224
Advanced healthcare materials 2025 Mar;14(6):e2403224
Uric acid promotes aortic valve calcification via mediating valve interstitial cell osteogenic differentiation and endothelial dysfunction.
Zhang J, Lei W, Zhou J, Zhang Y, Huang F, Chen M
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70437
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Mar 31;39(6):e70437
Transcription factor ONECUT3 regulates HDAC6/HIF-1α activity to promote the Warburg effect and tumor growth in colorectal cancer.
Huo R, Li W, Wu H, He K, Wang H, Zhang S, Jiang SH, Li R, Xue J
Cell death & disease 2025 Mar 3;16(1):149
Cell death & disease 2025 Mar 3;16(1):149
Amniotic fluid-derived exosomal miR-146a-5p ameliorates preeclampsia phenotypes by inhibiting HIF-1α/FLT-1 expression.
Lin J, Huang X, Zhang J, Yang W, Sun F, Huang B, Lu W, Wang X
Placenta 2025 Mar 25;162:35-44
Placenta 2025 Mar 25;162:35-44
Curcumin inhibits ferroptosis-mediated vascular occlusion by regulating the CXCL10/CXCR3 axis in retinopathy of prematurity.
Niu R, Wang J, Pan X, Ran M, Hao P, Zhang W, Guo Y, Zhang W
Molecular medicine (Cambridge, Mass.) 2025 Mar 24;31(1):113
Molecular medicine (Cambridge, Mass.) 2025 Mar 24;31(1):113
Estrogen via GPER downregulated HIF-1a and MIF expression, attenuated cardiac arrhythmias, and myocardial inflammation during hypobaric hypoxia.
Wowui PI, Mprah R, Ndzie Noah ML, Adu-Amankwaah J, Kanoseh AWL, Tao L, Chulu D, Yalley SK, Shaheen S, Sun H
Molecular medicine (Cambridge, Mass.) 2025 Mar 20;31(1):107
Molecular medicine (Cambridge, Mass.) 2025 Mar 20;31(1):107
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Simwela NV, Jaecklein E, Sassetti CM, Russell DG
eLife 2025 Mar 13;13
eLife 2025 Mar 13;13
Puerarin Targets HIF-1α to Modulate Hypoxia-Related Sphingolipid Metabolism in Diabetic Hepatopathy via the SPTLC2/Ceramide Pathway.
Cai M, Lai W, Chen H, Cao D, Zhang B, Wang F, Xian M, Wang S
Pharmaceuticals (Basel, Switzerland) 2025 Mar 12;18(3)
Pharmaceuticals (Basel, Switzerland) 2025 Mar 12;18(3)
Rifaximin Inhibits Small Bowel Angiodysplasia-Associated Angiogenesis by Attenuating LncRNA-HIF1A-AS2/miR-153-3p/HIF-1 α/Ang-2 Axis.
Peng S, Yin AN, Liao F, Zhao L
Current medical science 2025 Jun;45(3):574-584
Current medical science 2025 Jun;45(3):574-584
Exploring the mechanism of Shenhua tablet alleviating renal injury by regulating macrophage glycolysis hypoxia-inducible factor-1α/ pyruvate kinase M2 signaling pathway in diabetic kidney disease mice.
Yuanchun C, Jiaxing J, Qingmin LI, Xiaohong Z, Xiaofei J, Weijuan G, Xiangmei C, Wentao YU
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):528-537
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Jun;45(3):528-537
ROS-ATM-CHK2 axis stabilizes HIF-1α and promotes tumor angiogenesis in hypoxic microenvironment.
Bai M, Xu P, Cheng R, Li N, Cao S, Guo Q, Wang X, Li C, Bai N, Jiang B, Wu X, Song X, Sun C, Zhao M, Cao L
Oncogene 2025 Jun;44(21):1609-1619
Oncogene 2025 Jun;44(21):1609-1619
Sequential SDF-1/CGRP-releasing smart composite hydrogel promotes osteoporotic fracture healing by targeting sensory nerve-regulated bone remodeling.
Wang Y, Pan Z, Wang Q, Shu Y, Tan Z, Chen Y, He J, Wang J, Wang J, Yan J
Materials today. Bio 2025 Jun;32:101750
Materials today. Bio 2025 Jun;32:101750
Bufotalin loaded biomimetic nanodrug for combined chemo/photodynamic therapy of cancer.
Chen S, Fan J, Xie Q, Qin Y, Xie H, Xiao C, Wang W, Liu B
Materials today. Bio 2025 Jun;32:101684
Materials today. Bio 2025 Jun;32:101684
PTEN/PI3K/AKT pathway activation with hypoxia-induced human umbilical vein endothelial cell exosome for angiogenesis-based diabetic skin reconstruction.
Li Z, Bai Y, Wu H, Feng Y, Wang X, Zhao C, Wang X
Materials today. Bio 2025 Jun;32:101651
Materials today. Bio 2025 Jun;32:101651
Melatonin attenuates inflammatory bone loss by alleviating mitophagy and lactate production.
Lin Z, Gu Y, Liu Y, Chen Z, Fang S, Wang Z, Liu Z, Lin Q, Hu Y, Jiang N, Yu B, Liu G
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1351-1371
Apoptosis : an international journal on programmed cell death 2025 Jun;30(5-6):1351-1371
Antitumour and anti-angiogenesis efficacy of a multifunctional self-oxygenated active-targeting drug delivery system by encapsulating biological and chemotherapeutic drugs.
Zhu M, Xie Y, Li Z, Bao H, Miao D, Guo X, Wang S, Chen K, Chen H, Dai J, Yang N, Yu L, Pei J
Colloids and surfaces. B, Biointerfaces 2025 Jun;250:114549
Colloids and surfaces. B, Biointerfaces 2025 Jun;250:114549
IL-21 Loading CaMnCO(3) Vitality Backpacks Boost CAR-T Cell Synergistic Immunotherapy.
Wang B, Xue Y, Jia Y, Duan Y, Li D, Sui M, Feng Y, Wang L, Ding H, Wang X, Zhang T, Sun Y, Liu H, Qi J, Duan J, Zhao S, Zhu Q
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(25):e2501645
Small (Weinheim an der Bergstrasse, Germany) 2025 Jun;21(25):e2501645
Triiodothyronine promotes the proliferation and chemoresistance of cholangiocarcinoma cells via HIF-1α/Glut1-stimulated glycolysis.
Huang D, Xu F, Xu L, Tang Z, Hu Y, Li J, Yu J
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167814
Biochimica et biophysica acta. Molecular basis of disease 2025 Jun;1871(5):167814
Hif-1α regulation of the Tet1-β-catenin-Dicer1-miRNAs pathway is involved in depression-like behavior in prenatal hypoxic male offspring.
Zhao Z, Zeng H, Yu X, Shi Y, Zhao Y, Song Y, Li L, Gao Q, Sun M, Wang B
Neuroscience 2025 Jun 7;576:155-166
Neuroscience 2025 Jun 7;576:155-166
Investigating the Mechanism of Emodin in Rheumatoid Arthritis Through the HIF-1α/NLRP3 Pathway and Mitochondrial Autophagy.
Du D, Zhou L, Tian J, Cheng L, Zhang H, Tang Y, Qiu Z, Zhang T, Rong X
Current issues in molecular biology 2025 Jun 25;47(7)
Current issues in molecular biology 2025 Jun 25;47(7)
Macrophage extracellular traps as key mediators of scleral remodeling in myopia induced by hypoxia and activated platelets.
Feng Q, Yuan J, Hu Y, Feng C, Lin X, Liu S, Ji S, Mao X, Lin X, Cong J, Li X, Li X, Li H, Yan D, Dai J
Cell reports 2025 Jun 24;44(6):115771
Cell reports 2025 Jun 24;44(6):115771
Hypoxia upregulates the expression of PD-L1 via NPM1 in breast cancer.
Yu Y, Sun R, Hu F, Ding Z, Li X, Han J, Liang L, Wang T, Xi G, Dong X, Li Y, Zhao X, Zhang D
Journal for immunotherapy of cancer 2025 Jun 23;13(6)
Journal for immunotherapy of cancer 2025 Jun 23;13(6)
ALDOC and PGK1 coordinately induce glucose metabolism reprogramming and promote development of colorectal cancer.
Huang L, Tong Y, Li X, Wang W, Wang Z, Chen B, E J, Zhou R, Wang H, He J
Molecular medicine (Cambridge, Mass.) 2025 Jun 15;31(1):239
Molecular medicine (Cambridge, Mass.) 2025 Jun 15;31(1):239
Platelet Membrane-Coated Drug-Loaded Nanoparticles for Dual-Modal Imaging and Photodynamic Therapy in Triple-Negative Breast Cancer.
Ma K, Yang M, Pan Y, Bao Y, Bao Y, Mai X
ACS applied materials & interfaces 2025 Jun 11;17(23):33513-33527
ACS applied materials & interfaces 2025 Jun 11;17(23):33513-33527
Establishment of cell size-dependent growth rate via differential scaling of metabolite uptake and release.
Meliala I, Chen J, Lyu J, Björklund M
Proceedings of the National Academy of Sciences of the United States of America 2025 Jun 10;122(23):e2425347122
Proceedings of the National Academy of Sciences of the United States of America 2025 Jun 10;122(23):e2425347122
MOTS-c attenuates lung ischemia-reperfusion injury via MYH9-Dependent nuclear translocation and transcriptional activation of antioxidant genes.
Li X, Zhan F, Qiu G, Lu P, Shen Z, Qi Y, Wu M, Chu M, Feng J, Wen Z, Yao X, Wang A, Jin W, Zhang X, Liao J, Zhang J, Song M, Wang W, Wang X
Redox biology 2025 Jul;84:103681
Redox biology 2025 Jul;84:103681
Investigating the Therapeutic Potential of Salvianolic Acid B in Ischemic Wound Healing: In Vivo and In Vitro Study.
Tsai Y, Sun J, Liu Y, Chong C, Zheng D, Zhang Y, Yu L
Aesthetic plastic surgery 2025 Jul;49(13):3814-3827
Aesthetic plastic surgery 2025 Jul;49(13):3814-3827
Spatiotemporally Programming Microenvironment to Recapitulate Endochondral Ossification via Greenhouse-Inspired Bionic Niche.
Liu X, Zhao Y, Wu X, Zhou Y, Liu Y, Wang S, Zhang Y, Yang H, Song F, Huang C
Advanced materials (Deerfield Beach, Fla.) 2025 Jul;37(28):e2504057
Advanced materials (Deerfield Beach, Fla.) 2025 Jul;37(28):e2504057
Biofabricated Adipose-Derived Mesenchymal Cell Sheets Recover Cryo-Injured Kidneys in Rats.
Kitahara R, Imamura T, Domen T, Matsumoto Y, Inoue Y, Ogawa N, Saito T, Ueno M, Minagawa T, Ogawa T, Ishizuka O
Tissue engineering. Part A 2025 Jul;31(13-14):1005-1014
Tissue engineering. Part A 2025 Jul;31(13-14):1005-1014
Tβ4-Engineered ADSC Extracellular Vesicles Rescue Cell Senescence Through Separable Microneedle Patches for Diabetic Wound Healing.
Ding Y, Wang J, Li J, Cheng Y, Zhou S, Zhang Y, Zhao Y, Zhou M
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(26):e2505009
Neuraminidase 1 Exacerbated Glycolytic Dysregulation and Cardiotoxicity by Destabilizing SIRT1 through Interactions with NRF2 and HIF1α.
Gao T, Tang Y, Zeng T, Wang J, Zhang X, Liu Q, Guan X, Tang X, Lu G, Li J, Liu M, Zhang D, Lv S, Gu J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414504
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(25):e2414504
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.
Quan X, Yi H, Huang M, Chen D
Mutation research 2025 Jul-Dec;831:111916
Mutation research 2025 Jul-Dec;831:111916
A High-Calorie Diet Aggravates Lipopolysaccharide-Induced Pulmonary Inflammation in Juvenile Rats via Hypothalamic-Pituitary-Adrenal Axis-Related Pathways.
Li Q, Liu H, Bai C, Jiang L, Su C, Qin X, Liu T, Gu X
International journal of molecular sciences 2025 Jul 8;26(14)
International journal of molecular sciences 2025 Jul 8;26(14)
Treatment targets of cellular senescence and circadian rhythms in ischemic stroke.
Zeng F, Wang M, He M, Li Z, Zhang Y
Medicine 2025 Jul 4;104(27):e43220
Medicine 2025 Jul 4;104(27):e43220
Hypoxia-mediated HES4 promotes the proliferation and motility of hepatocellular carcinoma cell by enhancing COL4A2 transcription.
Zhao P, Xu H
Discover oncology 2025 Jul 25;16(1):1405
Discover oncology 2025 Jul 25;16(1):1405
Ameliorating Myocardial Infarction by Concurrent Pyroptosis Suppression and On-Demand Oxygen Production via Functionalized Nanocarrier.
Zhu W, Lu Y, Zong B, Chen Z, Ma Y, Wang H, Cao P, Han B
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
ACS applied materials & interfaces 2025 Jul 23;17(29):41626-41636
Aberrant Notch-signaling promotes tumor angiogenesis in esophageal squamous-cell carcinoma.
Li C, Wu P, Xie X, Chen X, Chen L, Zhu L, Xuan Z, Liu T, Tan W, Zhang S, Lin D, Wu C
Signal transduction and targeted therapy 2025 Jul 22;10(1):233
Signal transduction and targeted therapy 2025 Jul 22;10(1):233
Expression and clinical significance of AUF1 and HIF-1α in papillary thyroid carcinoma.
Zhang H, Li X, Li Y, Li S, Yan G, Chang W
World journal of surgical oncology 2025 Jul 1;23(1):252
World journal of surgical oncology 2025 Jul 1;23(1):252
Müller cells are activated in response to retinal outer nuclear layer degeneration in rats subjected to simulated weightlessness conditions.
Mu Y, Zhang N, Wei D, Yang G, Yao L, Xu X, Li Y, Xue J, Zhang Z, Chen T
Neural regeneration research 2025 Jul 1;20(7):2116-2128
Neural regeneration research 2025 Jul 1;20(7):2116-2128
THSG counteracts microglial glycolytic reprogramming and neuronal necroptosis both in vivo and in vitro under conditions of neuroinflammation.
Guo Z, Zhong S, Bai J, Lang X, Cao M, Hu Y, Qin X, Sun Y
Scientific reports 2025 Jul 1;15(1):21721
Scientific reports 2025 Jul 1;15(1):21721
Tea polyphenols nanoparticles integrated with microneedles multifunctionally boost 5-aminolevulinic acid photodynamic therapy for skin cancer.
Wang Y, Fu S, Zeng Y, Jiao S, Chai G, Xu Y
Journal of colloid and interface science 2025 Jan;677(Pt A):446-458
Journal of colloid and interface science 2025 Jan;677(Pt A):446-458
PGK1 Is Involved in the HIF-1 Signaling Pathway as a Hub Gene for Ferroptosis After Traumatic Brain Injury.
Wang Z, Tian J, Wang L, Yan H, Feng S, Zhang Y
Molecular neurobiology 2025 Jan;62(1):233-245
Molecular neurobiology 2025 Jan;62(1):233-245
Baicalein suppresses inflammation and attenuates acute lung injury by inhibiting glycolysis via HIF‑1α signaling.
Liu Z, Zheng X, Li N, Wang Z
Molecular medicine reports 2025 Jan;31(1)
Molecular medicine reports 2025 Jan;31(1)
AMPK-regulated glycerol excretion maintains metabolic crosstalk between reductive and energetic stress.
Zhai X, Yang R, Chu Q, Guo Z, Hou P, Li X, Bai C, Lu Z, Qiao L, Fu Y, Niu J, Li B
Nature cell biology 2025 Jan;27(1):141-153
Nature cell biology 2025 Jan;27(1):141-153
Unraveling pathogenesis and potential biomarkers for autism spectrum disorder associated with HIF1A pathway based on machine learning and experiment validation.
Cui J, Li H, Hu C, Zhang F, Li Y, Weng Y, Yang L, Li Y, Yao M, Li H, Luo X, Hao Y
Neurobiology of disease 2025 Jan;204:106763
Neurobiology of disease 2025 Jan;204:106763
Morusin Reverses Epithelial-Mesenchymal Transition in Gallbladder Cancer Cells by Regulating STAT3/HIF-1α Signaling.
Ji L, Chai Y, Tong C, Hu Y, Li J, Lu B, Yu J
Chemical biology & drug design 2025 Jan;105(1):e70054
Chemical biology & drug design 2025 Jan;105(1):e70054
CircFAM64A(3) promoted bladder cancer proliferation and inhibited CD8 + T cell via sponging to miR-149-5p and activated IL-6/JAK/STAT pathway.
Zhuang J, Zhou M, Yu H, Zhou R, Bai K, Lv J, Li K, Cheng Y, Yang H, Yang X, Lu Q
International immunopharmacology 2025 Jan 3;145:113762
International immunopharmacology 2025 Jan 3;145:113762
Detection of serum lactate dehydrogenase A and its metabolites on placental function in patients with intrahepatic cholestasis of pregnancy.
Huang H, Gao J, Dong R, Wang R, Li L, Wang G, Shi Y, Luo K, Chen J, Yuan W, Tian X, Zhao H, Zhang T
International immunopharmacology 2025 Jan 3;145:113739
International immunopharmacology 2025 Jan 3;145:113739
Hypoxia Dependent Inhibition of Glioblastoma Cell Proliferation, Invasion, and Metabolism by the Choline-Kinase Inhibitor JAS239.
Kelly CL, Wydrzynska M, Phelan MM, Osharovich S, Delikatny EJ, Sée V, Poptani H
Metabolites 2025 Jan 26;15(2)
Metabolites 2025 Jan 26;15(2)
Red and blue LED light increases the survival rate of random skin flaps in rats after MRSA infection.
Tu Y, Pan C, Huang Y, Ye Y, Zheng Y, Cao D, Lv Y
Lasers in medical science 2025 Jan 23;40(1):34
Lasers in medical science 2025 Jan 23;40(1):34
LncRNA TUG1 mitigates chronic kidney disease through miR-542-3p/HIF-1α/VEGF axis.
Qian L, Hu W, Wang Y, Waheed YA, Hu S, Sun D, Li S
Heliyon 2025 Jan 15;11(1):e40891
Heliyon 2025 Jan 15;11(1):e40891
TREM2 affects DAM-like cell transformation in the acute phase of TBI in mice by regulating microglial glycolysis.
Wang L, Ouyang D, Li L, Cao Y, Wang Y, Gu N, Zhang Z, Li Z, Tang S, Tang H, Zhang Y, Sun X, Yan J
Journal of neuroinflammation 2025 Jan 13;22(1):6
Journal of neuroinflammation 2025 Jan 13;22(1):6
Impaired fatty acid import or catabolism in macrophages restricts intracellular growth of Mycobacterium tuberculosis.
Simwela NV, Jaecklein E, Sassetti CM, Russell DG
bioRxiv : the preprint server for biology 2025 Jan 11;
bioRxiv : the preprint server for biology 2025 Jan 11;
Hypoxia-responsive liposome enhances intracellular delivery of photosensitizer for effective photodynamic therapy.
Li P, Li J, Cheng J, Huang J, Li J, Xiao J, Duan X
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:277-287
Journal of controlled release : official journal of the Controlled Release Society 2025 Jan 10;377:277-287
Claudin-4 Stabilizes the Genome via Nuclear and Cell-Cycle Remodeling to Support Ovarian Cancer Cell Survival.
Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb PG, Nephew KP, Neville M, Woodruff ER, Bitler BG
Cancer research communications 2025 Jan 1;5(1):39-53
Cancer research communications 2025 Jan 1;5(1):39-53
LINC01224 promotes the Warburg effect in gastric cancer by activating the miR-486-5p/PI3K axis.
Bin Y, Liu M, He R, Tang P, Qu W, Wu D, Tan L, Wang Q, Jiang P, Hu H
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
In vitro cellular & developmental biology. Animal 2025 Feb;61(2):228-244
Modulation of the local angiotensin II: Suppression of ferroptosis and radiosensitivity in nasopharyngeal carcinoma via the HIF-1α-HILPDA axis.
Huang X, Lin K, Chen W, Zhang D, Khan M, Ye X, Wang B, Chen C, Tian Y, Yuan Y, Lin J
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
Radiotherapy and oncology : journal of the European Society for Therapeutic Radiology and Oncology 2025 Feb;203:110686
The mitochondrial DNAJC co-chaperone TCAIM reduces α-ketoglutarate dehydrogenase protein levels to regulate metabolism.
Jiahui W, Xiang Y, Youhuan Z, Xiaomin M, Yuanzhu G, Dejian Z, Jie W, Yinkun F, Shi F, Juncheng S, Masha H, Marcia H, Peiyi W, Yingjie X, Wen Y
Molecular cell 2025 Feb 6;85(3):638-651.e9
Molecular cell 2025 Feb 6;85(3):638-651.e9
HSPA5-mediated glioma hypoxia tolerance promotes M2 macrophage polarization under hypoxic microenvironment.
Yang H, Xue Y, Jiang Q, Tian Q, Xu J, Li J, Yang Q, Du M, Yang T, Wei X, Zhao M, Yan T, Chen X, Li L
International immunopharmacology 2025 Feb 6;147:113856
International immunopharmacology 2025 Feb 6;147:113856
MSC-exosomes pretreated by Danshensu extracts pretreating to target the hsa-miR-27a-5p and STAT3-SHANK2 to enhanced antifibrotic therapy.
Liang J, Zhao J, Yang L, Wang Q, Liao J, Li J, Zhuang W, Li F, He J, Tang Y, Chen H, Huang C
Stem cell research & therapy 2025 Feb 4;16(1):40
Stem cell research & therapy 2025 Feb 4;16(1):40
Endothelial AGGF1 promotes retinal angiogenesis by coordinating TNFSF12/FN14 signalling.
Cheng Y, Zhang M, Li C, Su L, Fu L, Wu S, Xu C, Sun B, Chen L
Nature communications 2025 Feb 4;16(1):1332
Nature communications 2025 Feb 4;16(1):1332
Specific effects of hypoxia-immune core gene ARHGAP11A on lung adenocarcinoma.
Sun K, Wang L, Zhang X, Chen H, Wang Z, Zhang J, Wang X, Lian C
Translational cancer research 2025 Feb 28;14(2):778-795
Translational cancer research 2025 Feb 28;14(2):778-795
AR Deficiency Protects Against Sepsis-Induced Acute Lung Injury by Inhibiting Macrophage M1 Polarization and Inflammatory Cytokine Secretion.
Wang X, Yin D, Sun J, Zhang L, Ye Y, Guo Q
Inflammation 2025 Dec;48(6):4203-4224
Inflammation 2025 Dec;48(6):4203-4224
VH032 suppresses glioma proliferation by inhibiting the VHL/HIF-1α/VEGF pathway.
Zhang Y, Zhu XY, Gu JR, Wang P, Wen YJ, Hou SZ, Yang JY, Gu JH
Biochemistry and biophysics reports 2025 Dec;44:102254
Biochemistry and biophysics reports 2025 Dec;44:102254
An injectable phosphocreatine-grafted hydrogel incorporating hierarchically structured teriparatide/SrZnP-functionalized Zn-Cu particles for osteogenesis-angiogenesis coupling and osteoporotic bone regeneration.
Qin H, Guan Z, Wang Y, Zhao J, Xie Z, Li H, Zhang C, Sheng W, Yu F, Weng J, Chen Y, Wang D, Zeng H, Qian J
Materials today. Bio 2025 Dec;35:102272
Materials today. Bio 2025 Dec;35:102272
STC2 Serves as a Critical Hypoxic Effector in Keloid Pathogenesis by Orchestrating Fibroblasts Activation and ECM Remodelling.
Qian L, Deng S, Tian T, He Y, Li Y, Wang X, Tian T, Jiang M, Pan Y, Li D
Experimental dermatology 2025 Dec;34(12):e70193
Experimental dermatology 2025 Dec;34(12):e70193
Porcine reproductive and respiratory syndrome virus activates the pentose phosphate pathway via the ROS/HIF-1α/G6PD axis to promote viral replication.
Ma YX, Yang JM, Mei HT, Zeng L, Yang GY, Wang J, Ming SL, Chu BB
Virulence 2025 Dec;16(1):2585639
Virulence 2025 Dec;16(1):2585639
N-formyl methionine mediates NETosis of neutrophil to promote sepsis-induced cardiomyopathy via the FPR1 pathway.
Chen S, Lin H, Gu H, Yu X, Xiang J, Xu L, Ye G, Shan Y, Wang Y
International immunopharmacology 2025 Dec 3;166:115602
International immunopharmacology 2025 Dec 3;166:115602
Shikonin inhibits multiple tumor malignant phenotypes and is associated with Hedgehog pathway downregulation in lung adenocarcinoma.
Wang HG, Lu MX, Sheng ML, Lou YB, Xiao YC, Guo A, Yu ZH
Scientific reports 2025 Dec 24;15(1):44516
Scientific reports 2025 Dec 24;15(1):44516
Hypoxic tumor exosomes suppress macrophage inflammation and ferroptosis via NDUFV2 to enhance bystander tumor radioresistance.
Zhang J, Jin X, Abulaihaiti M, Liu X, Zeng L, Xiao Y, Pan Y, Bai Y, Xu Y, Shao C, Zhang J
Cell death & disease 2025 Dec 19;17(1):109
Cell death & disease 2025 Dec 19;17(1):109
Hypoxia induced VEGF secretion promotes resistance to bispecific T-cell engagers.
Xu M, Barakzai SK, Kumar R, Veillard I, Kim E, Bregar A, Eisenhauer E, Penson R, Bouberhan S, Filipi J, Colella T, Bond T, Clark C, Lin LH, Ruan J, Wang C, Qin X, Sarosiek K, Rueda B, Castro C, Spriggs DR, Yeku OO
Signal transduction and targeted therapy 2025 Dec 19;10(1):405
Signal transduction and targeted therapy 2025 Dec 19;10(1):405
Sirt1 attenuates necrotizing enterocolitis via Hif-1α deacetylation-mediated suppression of Bnip3-Dependent mitophagy.
Zhu L, Huang M, He L, Rong Z
Free radical biology & medicine 2025 Dec 16;241:150-160
Free radical biology & medicine 2025 Dec 16;241:150-160
De-ubiquitinase USP35 promotes peritoneal dissemination of gastric cancer by regulating metabolic reprogramming.
Yan L, Chen M, Cai L, Liu A, Li F, Zhang Y, Peng X, Wang Y, Li R, Mei J, Zou D, Gao X, Wang Y, Wu L, Zhang Y
Cell death & disease 2025 Dec 10;16(1):889
Cell death & disease 2025 Dec 10;16(1):889
SETD5 facilitates stemness and represses ferroptosis via m6A-mediating PKM2 stabilization in non-small cell lung cancer.
Liu X, Cui Y, Gong J, Yu X, Cui Y, Xuan Y
Oncogene 2025 Aug;44(29):2474-2489
Oncogene 2025 Aug;44(29):2474-2489
Chiral nanoassembly remodels tumor microenvironment through non-oxygen-dependent depletion lactate for effective photodynamic immunotherapy.
Zhang X, Bai J, Sun S, Li Y, Li X, Meng G, Cheng W, Yin Y, Wang Z, Wang B
Biomaterials 2025 Aug;319:123203
Biomaterials 2025 Aug;319:123203
A tumor microenvironment-responsive nanocomposite for enhanced copper retention and hypoxia reversal to promote cuproptosis in tumor treatment.
Chen W, Lin C, Gao Z, Huang Y, Wang X, Zhang Q, Zhang Y, Tan M, Hou Z
Acta biomaterialia 2025 Aug;202:463-475
Acta biomaterialia 2025 Aug;202:463-475
Cr (VI) induces lactate utilization through HIF-1α/MCT1 dependent on p53 protein level.
Li S, Guo Y, Cui X, Li L, Fan J, Cao J
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Aug;202:115505
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2025 Aug;202:115505
Annexin A2 binds the 3'-UTR of H2AX mRNA and regulates histone-H2AX-derived hypoxia-inducible factor 1-alpha activation.
Zhang S, Wang YS, Li Y, To KI, Zhang ET, Jin YH
Cellular signalling 2025 Aug;132:111781
Cellular signalling 2025 Aug;132:111781
Elevated Histone Lactylation Mediates Ferroptosis Resistance in Endometriosis Through the METTL3-Regulated HIF1A/HMOX1 Signaling Pathway.
Liang Z, Liu J, Gou Y, Wang H, Li Z, Cao Y, Zhang H, Bai R, Zhang Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e08220
Hypoxia-induced genome-wide DNA demethylation by DNMT3A and EMT of cancer cells.
Chatterjee B, Majumder P, Chen CC, Wang JP, Su PH, Lai HC, Liu CC, Lin HN, Yu CA, Yuan HS, Shen CJ
Cellular & molecular biology letters 2025 Aug 5;30(1):95
Cellular & molecular biology letters 2025 Aug 5;30(1):95
Nucleus-translocated glucokinase functions as a protein kinase to phosphorylate TAZ and promote tumour growth.
Zhao G, Luo S, Zhao H, Ma Q, Jiang H, Wang L, Liu J, Guo D, Wang R, Xu Q, Lun J, Xie R, Duan Y, Ma L, Qiu W, Fang J, Lu Z
Nature communications 2025 Aug 4;16(1):7156
Nature communications 2025 Aug 4;16(1):7156
Kurarinone protects against renal injury and fibrosis after unilateral ureteral obstruction through enhancement of the Nrf-2 signaling pathway.
Dong T, Zhao D, Jiang S, Gu Y, Wang C, Yang Q, Liu T, Liu X
Journal of molecular histology 2025 Aug 29;56(5):286
Journal of molecular histology 2025 Aug 29;56(5):286
Silybin Mitigates Post-Myocardial Infarction Heart Failure in Mice via Modulation of HIF-1α-Driven Glycolysis and Energy Metabolism.
Wang M, Chen J, Zhang Z, Wang T, Zhao J, Wang X, Wang J, Zhuang H
Nutrients 2025 Aug 28;17(17)
Nutrients 2025 Aug 28;17(17)
Succinate links TCA cycle dysfunction to inflammation by activating HIF-1α signaling in acute kidney injury.
Xu B, Zhu Z, Shu H, Wang H, Lu X, Zhu X
International immunopharmacology 2025 Aug 28;161:115105
International immunopharmacology 2025 Aug 28;161:115105
CircCRIM1 promotes the translation of HIF-1α protein through its interaction with PTBP3 and enhances malignant progression and angiogenesis in glioblastoma.
Liu Y, Luo Y, Song D, Meng W, Bai J, Li Y, Lin X, Wang J, Fan D, Gu Y
Biochemical pharmacology 2025 Aug 27;242(Pt 1):117279
Biochemical pharmacology 2025 Aug 27;242(Pt 1):117279
Synergistic Neuroprotection of Artesunate and Tetramethylpyrazine in Ischemic Stroke, Mechanisms of Blood-Brain Barrier Preservation.
Liang Y, Deng S, Li Y, Qu S, Liu C, Wang L, Chen L, Liu T, Li Y
International journal of molecular sciences 2025 Aug 18;26(16)
International journal of molecular sciences 2025 Aug 18;26(16)
NDUFB9 ameliorates CUMS-induced depression-like behavior by promoting mitophagy.
Sun Y, Li L, Yang X, Yin S, Xiao Z
Translational psychiatry 2025 Aug 18;15(1):292
Translational psychiatry 2025 Aug 18;15(1):292
Oroxin A suppresses colorectal tumor growth by regulating the TRIM24-mediated ferroptosis and TSPO pathway.
He C, Weng C, Lai Z, Luo H, Chen K, Li T, Li W, Li G
iScience 2025 Aug 15;28(8):113196
iScience 2025 Aug 15;28(8):113196
Inulin and hyaluronic acid-based oral liposome for enhanced photo-chemotherapy against orthotopic colon cancer and its reversal effects on tumor hypoxia and intestinal microbiota.
Wang N, Hu J, Jin L, Wang S, Zeng B, Liu Y, Jin A, Piao J, Chen L, Huang W, Gao Z, Wang Y, Cui W, Jin M
International journal of biological macromolecules 2025 Apr;304(Pt 2):140996
International journal of biological macromolecules 2025 Apr;304(Pt 2):140996
Nobiletin: a potential erythropoietin receptor activator protects renal cells against hypoxia.
Liu N, Sun Y, Liu J, Zhang Y, Yi X, Yan W, Cui X, Guo T, Zhao W, Han S, Ma W, Cao Y, Chen L
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):842-860
Apoptosis : an international journal on programmed cell death 2025 Apr;30(3-4):842-860
Sodium Hyaluronate-PDGF Repairs Cartilage and Subchondral Bone Microenvironment via HIF-1α-VEGF-Notch and SDF-1-CXCR4 Inhibition in Osteoarthritis.
Wang Z, Zhu P, Li H, Ye B, Luo Q, Cheng J, Cai Y
Journal of cellular and molecular medicine 2025 Apr;29(7):e70515
Journal of cellular and molecular medicine 2025 Apr;29(7):e70515
Hypoxia amplifies arecoline-induced invasion and metastasis in oral squamous cell carcinoma - Insights into TGF-β1 signaling and collagen production.
Wu FC, Ting CC, Jeng JH, Chen H, Kim YD, Wu CC, Kao YH, Tseng CH, Chen YK, Ogasawara T, Hoshi K, Lo WL, Takahashi T, Yang YH, Ko EC
Journal of dental sciences 2025 Apr;20(2):1129-1138
Journal of dental sciences 2025 Apr;20(2):1129-1138
Hypoxia-induced PRMT1 methylates HIF2β to promote breast tumorigenesis via enhancing glycolytic gene transcription.
Li WJ, Chen YC, Lin YA, Zou YQ, Hu GS, Yang JJ, Nie XY, Li MY, Wang YR, He YH, Zhao Y, Tan YH, Deng X, He WL, Cheng Y, Fu FM, Liu W
Cell reports 2025 Apr 22;44(4):115487
Cell reports 2025 Apr 22;44(4):115487
The Role of Hippo Signaling in Brain Arteriovenous Malformations: Molecular Insights into Post-Embolization Remodeling.
Neyazi B, Swiatek VM, Karimpour MA, Stassen S, Stein KP, Rashidi A, Dumitru CA, Sandalcioglu IE
International journal of molecular sciences 2025 Apr 17;26(8)
International journal of molecular sciences 2025 Apr 17;26(8)
Estrogen receptor β alleviates colitis in intestinal epithelial cells and activates HIF-1a and ATG-9a-mediated autophagy.
Li J, Chen Y, Yu Q, Li S, Zhang X, Cheng Y, Fu X, Li J, Zhu L
Experimental cell research 2025 Apr 15;447(2):114520
Experimental cell research 2025 Apr 15;447(2):114520
Hypoxia-regulated miR-103-3p/FGF2 axis in adipose-derived stem cells promotes angiogenesis by vascular endothelial cells during ischemic tissue repair.
Lu Y, Cha D, Li Z, Xiao L, Liao X, Li S, Jiang X, Hu B, Yang Y, Liu H
International journal of cardiology 2025 Apr 15;425:133004
International journal of cardiology 2025 Apr 15;425:133004
MicroRNA-122-5p is upregulated in diabetic foot ulcers and decelerates the transition from the inflammatory to the proliferative stage.
Yuan MJ, Huang HC, Shi HS, Hu XM, Zhao Z, Chen YQ, Fan WJ, Sun J, Liu GB
World journal of diabetes 2025 Apr 15;16(4):100113
World journal of diabetes 2025 Apr 15;16(4):100113
Hypoxia-driven TNS4 fosters HNSCC tumorigenesis by stabilizing integrin α5β1 complex and triggering FAK-mediated Akt and TGFβ signaling pathways.
Zhao X, Mai Z, Liu L, Lu Y, Cui L, Yu J
International journal of biological sciences 2024;20(1):231-248
International journal of biological sciences 2024;20(1):231-248
The mouse gingiva and HIF-1α, a key gene of hypoxic environment, as tools for post-mortem time estimation.
Mascarell S, Torrens C, Andrique C, Foda A, Delabarde T, Ludes B, Collignon AM, Poliard A
PloS one 2024;19(11):e0311050
PloS one 2024;19(11):e0311050
Profiling hypoxia signaling reveals a lncRNA signature contributing to immunosuppression in high-grade glioma.
Li X, Xu J, Li X, Shi J, Wei C, Liang Q
Frontiers in immunology 2024;15:1471388
Frontiers in immunology 2024;15:1471388
Benserazide, a cystathionine beta-synthase (CBS) inhibitor, potentially enhances the anticancer effects of paclitaxel via inhibiting the S-sulfhydration of SIRT1 and the HIF1-α/VEGF pathway.
Zhao W, Feng S, Wang J, Zhang Z, Chen L, Jiang L, Li M, Wang T
Frontiers in pharmacology 2024;15:1404532
Frontiers in pharmacology 2024;15:1404532
Multifunctional injectable hydrogel system as a mild photothermal-assisted therapeutic platform for programmed regulation of inflammation and osteo-microenvironment for enhanced healing of diabetic bone defects in situ.
Zhu Y, Liu H, Wu P, Chen Y, Deng Z, Cai L, Wu M
Theranostics 2024;14(18):7140-7198
Theranostics 2024;14(18):7140-7198
Decreased lncRNA HNF4A-AS1 facilitates resistance to sorafenib-induced ferroptosis of hepatocellular carcinoma by reprogramming lipid metabolism.
Zhao Y, Han S, Zeng Z, Zheng H, Li Y, Wang F, Huang Y, Zhao Y, Zhuo W, Lv G, Wang H, Zhao G, Zhao E, Hu Y, Hu P, Zhao G
Theranostics 2024;14(18):7088-7110
Theranostics 2024;14(18):7088-7110
Hypoxia-induced TGFBI maintains glioma stem cells by stabilizing EphA2.
Chen Z, Wang J, Peng P, Liu G, Dong M, Zhang X, Zhang Y, Yang X, Wan L, Xiang W, Zhang S, Zhang B, Wu Q, Yu X, Wan F
Theranostics 2024;14(15):5778-5792
Theranostics 2024;14(15):5778-5792
Hypoxia macrophage-derived exosomal miR-26b-5p targeting PTEN promotes the development of keloids.
Dai S, Xu M, Pang Q, Sun J, Lin X, Chu X, Guo C, Xu J
Burns & trauma 2024;12:tkad036
Burns & trauma 2024;12:tkad036
PLAUR facilitates the progression of clear cell renal cell carcinoma by activating the PI3K/AKT/mTOR signaling pathway.
Qin T, Huang M, Wei W, Zhou W, Tang Q, Huang Q, Tang N, Gai S
PeerJ 2024;12:e17555
PeerJ 2024;12:e17555
Dandelion-shaped strontium-gallium microparticles for the hierarchical stimulation and comprehensive regulation of wound healing.
Ji M, Yuan Z, Ma H, Feng X, Ye C, Shi L, Chen X, Han F, Zhao C
Regenerative biomaterials 2024;11:rbae121
Regenerative biomaterials 2024;11:rbae121
The tourniquet's effects on skeletal muscle during total knee arthroplasty.
Johnsen M, Mousavizadeh R, Scott A, Havik S, Husby VS, Winther SB, Husby OS, Lian Ø
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Sep;42(9):1955-1963
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2024 Sep;42(9):1955-1963
Cyclophilin J limits linear ubiquitin signaling and controls colorectal cancer progression.
Sheng C, Yao C, Wang J, Mao Y, Fu L, Chen S
The Journal of biological chemistry 2024 Sep;300(9):107610
The Journal of biological chemistry 2024 Sep;300(9):107610
The miR-199a-5p/HIF1α dual-regulatory axis participates in hypoxia-induced aggressive phenotypes of oral squamous cell carcinoma (OSCC) cells.
Chen X, Yu J, Tian H, Cai X
International journal of clinical oncology 2024 Sep;29(9):1244-1254
International journal of clinical oncology 2024 Sep;29(9):1244-1254
Stable and oscillatory hypoxia differentially regulate invasibility of breast cancer associated fibroblasts.
Du W, Novin A, Liu Y, Afzal J, Liu S, Suhail Y, Kshitiz
Mechanobiology in medicine 2024 Sep;2(3)
Mechanobiology in medicine 2024 Sep;2(3)
Melatonin reverses EGFR-TKI therapeutic resistance by modulating crosstalk between circadian-related gene signature and immune infiltration patterns in patients with COVID-19 and lung adenocarcinoma.
Dai Z, Lin B, Cao Y, Wang L, Liao K, Guo L, Zhang J
Computers in biology and medicine 2024 Sep;180:108937
Computers in biology and medicine 2024 Sep;180:108937
Hypoxia activates the hypoxia-inducible factor-1α/vascular endothelial growth factor pathway in a prostatic stromal cell line: A mechanism for the pathogenesis of benign prostatic hyperplasia.
Zhang T, Mao C, Chang Y, Lyu J, Zhao D, Ding S
Current urology 2024 Sep;18(3):185-193
Current urology 2024 Sep;18(3):185-193
Enhanced glioma cell death with ZnO nanorod flowers and temozolomide combination therapy through autophagy and mitophagy pathways.
Li Y, Ma Y, Li J, Lu Y, Liu H, Gao M, Cao J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117149
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117149
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Li X, Wang G, Li N, Wang X, Fan W, Zhang Z, Li W, Liu J, Huang J, Liu X, Zhou Q, Hou S
Immunology 2024 Sep;173(1):141-151
Immunology 2024 Sep;173(1):141-151
Fluorinated perhexiline derivative attenuates vascular proliferation in pulmonary arterial hypertension smooth muscle cells.
Griffiths K, Grand RJ, Horan I, Certo M, Keeler RC, Mauro C, Tseng CC, Greig I, Morrell NW, Zanda M, Frenneaux MP, Madhani M
Vascular pharmacology 2024 Sep;156:107399
Vascular pharmacology 2024 Sep;156:107399
Claudin-4 remodeling of nucleus-cell cycle crosstalk maintains ovarian tumor genome stability and drives resistance to genomic instability-inducing agents.
Villagomez FR, Lang J, Nunez-Avellaneda D, Behbakht K, Dimmick HL, Webb P, Nephew KP, Neville M, Woodruff ER, Bitler BG
bioRxiv : the preprint server for biology 2024 Sep 7;
bioRxiv : the preprint server for biology 2024 Sep 7;
Intratumoral CXCL13(+) CD160(+) CD8(+) T cells promote the formation of tertiary lymphoid structures to enhance the efficacy of immunotherapy in advanced gastric cancer.
Wang J, Liang Y, Xue A, Xiao J, Zhao X, Cao S, Li P, Dong J, Li Y, Xu Z, Yang L
Journal for immunotherapy of cancer 2024 Sep 6;12(9)
Journal for immunotherapy of cancer 2024 Sep 6;12(9)
HIF-1α-HPRT1 axis promotes tumorigenesis and gefitinib resistance by enhancing purine metabolism in EGFR-mutant lung adenocarcinoma.
Geng P, Ye F, Dou P, Hu C, He J, Zhao J, Li Q, Bao M, Li X, Liu X, Xu G
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):269
Journal of experimental & clinical cancer research : CR 2024 Sep 30;43(1):269
RNA binding protein ELAVL1-mediated USP33 stabilizes HIF1A to promote pathological proliferation, migration and angiogenesis of RECs.
Xie J, Jiang J, Wang X, Zuo X, Jia Y
International ophthalmology 2024 Sep 25;44(1):393
International ophthalmology 2024 Sep 25;44(1):393
KRT19 is regulated by miR-642a-5p and promotes pancreatic cancer progression through the Wnt/β-catenin pathway.
Shi HQ, Li X, Chen Z, Dong S, Ye C, Hou S, Fan DA, Zhang H, Zhou WC
iScience 2024 Sep 20;27(9):110782
iScience 2024 Sep 20;27(9):110782
The p-MYH9/USP22/HIF-1α axis promotes lenvatinib resistance and cancer stemness in hepatocellular carcinoma.
Shan Q, Yin L, Zhan Q, Yu J, Pan S, Zhuo J, Zhou W, Bao J, Zhang L, Hong J, Xiang J, Que Q, Chen K, Xu S, Wang J, Zhu Y, He B, Wu J, Xie H, Zheng S, Feng T, Ling S, Xu X
Signal transduction and targeted therapy 2024 Sep 19;9(1):249
Signal transduction and targeted therapy 2024 Sep 19;9(1):249
Electroacupuncture enhances cerebral blood perfusion by inhibiting HIF-1α in rat subarachnoid hemorrhage.
Wang Y, Chen Y, Li Z, Tang L, Wen D, Wu Y, Guo Z
Brain research 2024 Sep 15;1839:149010
Brain research 2024 Sep 15;1839:149010
Hypoxia-induced Semaphorin 3A promotes the development of endometriosis through regulating macrophage polarization.
Yang R, Yang F, Wei Y, Huang B, Cao T, Tan H, Liu D, Zou Q, Wen J, Wen L, Lu X, Yu C, Cai H, Xie X, Jiang S, Yao S, Liang Y
International immunopharmacology 2024 Sep 10;138:112559
International immunopharmacology 2024 Sep 10;138:112559
BCLAF1 is Expressed as a Potential Anti-oncogene in Bile Duct Cancer.
Zhou Y, Ran X, Han M
Biochemical genetics 2024 Oct;62(5):3681-3694
Biochemical genetics 2024 Oct;62(5):3681-3694
Transcription Factor TFAP2B Exerts Neuroprotective Effects Targeting BNIP3-Mediated Mitophagy in Ischemia/Reperfusion Injury.
Peng Y, Jia J, Zhang M, Ma W, Cui Y, Yu M
Molecular neurobiology 2024 Oct;61(10):7319-7334
Molecular neurobiology 2024 Oct;61(10):7319-7334
Nrf2/ASPM axis regulated vasculogenic mimicry formation in hepatocellular carcinoma under hypoxia.
Zhang Y, Che N, Wang S, Meng J, Zhao N, Han J, Dong X, Li Y, Mo J, Zhao X, Liu T
Journal of gastroenterology 2024 Oct;59(10):941-957
Journal of gastroenterology 2024 Oct;59(10):941-957
Disruption of BACH1 Protects AC16 Cardiomyocytes Against Hypoxia/Reoxygenation-Evoked Injury by Diminishing CDKN3 Transcription.
Li Y, Zhou Y, Pei H, Li D
Cardiovascular toxicology 2024 Oct;24(10):1105-1115
Cardiovascular toxicology 2024 Oct;24(10):1105-1115
Enhancing Endogenous Hyaluronic Acid in Osteoarthritic Joints with an Anti-Inflammatory Supramolecular Nanofiber Hydrogel Delivering HAS2 Lentivirus.
Zhou F, Chen M, Qian Y, Yuan K, Han X, Wang W, Guo JJ, Chen Q, Li B
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400542
Small (Weinheim an der Bergstrasse, Germany) 2024 Oct;20(40):e2400542
The effects of BMP2 and the mechanisms involved in the invasion and angiogenesis of IDH1 mutant glioma cells.
Xu H, Cao Y, Ruan J, Wang F, He Y, Yang L, Yu T, Du F, Zhang N, Cao X
Journal of neuro-oncology 2024 Oct;170(1):161-171
Journal of neuro-oncology 2024 Oct;170(1):161-171
Non-pharmacological interventions of intermittent fasting and pulsed radiofrequency energy (PRFE) combination therapy promote diabetic wound healing.
Huang Y, Qin P, Zhou P, Long B, Zhang S, Gao R, Zhu B, Li Y, Li Q
Nutrition & diabetes 2024 Oct 7;14(1):83
Nutrition & diabetes 2024 Oct 7;14(1):83
The chemically stable analogue of resolvin D1 ameliorates experimental autoimmune encephalomyelitis by mediating the resolution of inflammation.
Zhang Q, Zhang Y, Zou M, Wu H, Liu C, Mi Y, Zhu J, Wang Y, Jin T
International immunopharmacology 2024 Oct 25;140:112740
International immunopharmacology 2024 Oct 25;140:112740
TRIM55 restricts the progression of hepatocellular carcinoma through ubiquitin-proteasome-mediated degradation of NF90.
Luo C, Lu Y, Fang Q, Lu J, Zhan P, Xi W, Wang J, Chen X, Yao Q, Wang F, Yin Z, Xie C
Cell death discovery 2024 Oct 17;10(1):441
Cell death discovery 2024 Oct 17;10(1):441
HIF-1α knockdown suppresses breast cancer metastasis via epithelial mesenchymal transition Abrogation.
Zhao J, Zhang H, Liu Y, Lu G, Wang Z, Mo Q, Wang G, Shen Y, Jiao L
Heliyon 2024 Oct 15;10(19):e37900
Heliyon 2024 Oct 15;10(19):e37900
SOX9 promotes hypoxic pulmonary hypertension through stabilization of DPP4 in pulmonary artery smooth muscle cells.
Guo YZ, Cui HY, Cai MY, Wang D, Deng WP, Hu CP
Experimental cell research 2024 Oct 1;442(2):114254
Experimental cell research 2024 Oct 1;442(2):114254
ZNF740 facilitates the malignant progression of hepatocellular carcinoma via the METTL3/HIF‑1A signaling axis.
Zhang H, Han B, Tian S, Gong Y, Liu L
International journal of oncology 2024 Nov;65(5)
International journal of oncology 2024 Nov;65(5)
Sodium citrate targeting Ca(2+)/CAMKK2 pathway exhibits anti-tumor activity through inducing apoptosis and ferroptosis in ovarian cancer.
Wu Y, Jia C, Liu W, Zhan W, Chen Y, Lu J, Bao Y, Wang S, Yu C, Zheng L, Sun L, Song Z
Journal of advanced research 2024 Nov;65:89-104
Journal of advanced research 2024 Nov;65:89-104
Downregulation of C1R promotes hepatocellular carcinoma development by activating HIF-1α-regulated glycolysis.
Ma Y, Wang Y, Tuo P, Meng Z, Jiang B, Yuan Y, Ding Y, Naeem A, Guo X, Wang X
Molecular carcinogenesis 2024 Nov;63(11):2237-2253
Molecular carcinogenesis 2024 Nov;63(11):2237-2253
SPAG4 enhances mitochondrial respiration and aerobic glycolysis in colorectal cancer cells by activating the PI3K/Akt signaling pathway.
Zhou J, Sun H, Zhou H, Liu Y
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70009
Journal of biochemical and molecular toxicology 2024 Nov;38(11):e70009
Association of the podocyte phenotype with extracapillary hypercellularity in patients with diabetic kidney disease.
Han W, Zheng Q, Zhang Z, Wang X, Gao L, Niu D, Wang X, Li R, Wang C
Journal of nephrology 2024 Nov;37(8):2209-2222
Journal of nephrology 2024 Nov;37(8):2209-2222
Adipose ADM2 ameliorates NAFLD via promotion of ceramide catabolism.
Wang P, Zhang SY, Dong Y, Zeng G, Liu H, Wang X, Jiang C, Li Y
Acta pharmaceutica Sinica. B 2024 Nov;14(11):4883-4898
Acta pharmaceutica Sinica. B 2024 Nov;14(11):4883-4898
Lutein protects senescent ciliary muscle against oxidative stress through the Keap1/Nrf2/ARE pathway.
Gao N, Gao X, Du M, Xiang Y, Zuo H, Huang R, Wan W, Hu K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155982
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155982
m6A-methylase METTL3 promotes retinal angiogenesis through modulation of metabolic reprogramming in RPE cells.
Zhou Q, Liu X, Lu H, Li N, Meng J, Huang J, Zhang Z, Liu J, Fan W, Li W, Li X, Liu X, Zuo H, Yang P, Hou S
Journal of neuroinflammation 2024 Nov 6;21(1):289
Journal of neuroinflammation 2024 Nov 6;21(1):289
Targeted inhibition of CHKα and mTOR in models of pancreatic ductal adenocarcinoma: A novel regimen for metastasis.
Liu J, Jiang B, Xu W, Liu Q, Huang H, Chang X, Ma G, Xu X, Zhou L, Xiao GG, Guo J
Cancer letters 2024 Nov 28;605:217280
Cancer letters 2024 Nov 28;605:217280
Target-Engineered Liposomes Decorated with Nanozymes Alleviate Liver Fibrosis by Remodeling the Liver Microenvironment.
Yang D, Liu K, Cai C, Xi J, Yan C, Peng Z, Wang Y, Jing L, Zhang Y, Xie F, Li X
ACS applied materials & interfaces 2024 Nov 27;16(47):64536-64553
ACS applied materials & interfaces 2024 Nov 27;16(47):64536-64553
Influenza A virus-induced glycolysis facilitates virus replication by activating ROS/HIF-1α pathway.
Zhang Y, Chang L, Xin X, Qiao Y, Qiao W, Ping J, Xia J, Su J
Free radical biology & medicine 2024 Nov 20;225:910-924
Free radical biology & medicine 2024 Nov 20;225:910-924
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway.
Ni J, Zhang Q, Jiang L, Wang H, Zhang C, Deng J
Scientific reports 2024 Nov 16;14(1):28327
Scientific reports 2024 Nov 16;14(1):28327
EHD1 promotes breast cancer metastasis through upregulating HIF2a expression via activating mTOR pathway.
Gao X, Li J, Feng X, Xie Y, Zhang J, Liu J, Wang B, Liu P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70168
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Nov 15;38(21):e70168
Proteomic analysis reveals the mechanism that low molecular weight hyaluronic acid enhances cell migration in keratinocyte.
Liu J, Wang BY, Liu CH, Yang C, Zhao BT
Journal of pharmaceutical and biomedical analysis 2024 Nov 15;250:116402
Journal of pharmaceutical and biomedical analysis 2024 Nov 15;250:116402
Effect of exercise during pregnancy on offspring development through ameliorating high glucose and hypoxia in gestational diabetes mellitus.
Tang YB, Wang LS, Wu YH, Zhang LX, Hu LY, Wu Q, Zhou ML, Liang ZX
World journal of diabetes 2024 Nov 15;15(11):2203-2219
World journal of diabetes 2024 Nov 15;15(11):2203-2219
Iron-based MOF with Catalase-like activity improves the synergistic therapeutic effect of PDT/ferroptosis/starvation therapy by reversing the tumor hypoxic microenvironment.
Chen Y, Chen Y, Wang Z, Yang L, Zhang Y, Zhang Z, Jia L
Journal of nanobiotechnology 2024 Nov 14;22(1):705
Journal of nanobiotechnology 2024 Nov 14;22(1):705
One-Step Gas Foaming Strategy for Constructing Strontium Nanoparticle Decorated 3D Scaffolds: a New Platform for Repairing Critical Bone Defects.
Chen Y, Li Y, Wang X, Mo X, Chen Y, Deng Z, Ye X, Yu J
ACS applied materials & interfaces 2024 Nov 13;16(45):61664-61678
ACS applied materials & interfaces 2024 Nov 13;16(45):61664-61678
Triggered Cascade-Activation Nanoplatform to Alleviate Hypoxia for Effective Tumor Immunotherapy Guided by NIR-II Imaging.
Ji Y, Qu S, Shi G, Fan L, Qian J, Sun Z, Lu F, Han X
ACS nano 2024 Nov 12;18(45):31421-31434
ACS nano 2024 Nov 12;18(45):31421-31434
Synergistic anticancer effects of ginsenoside CK and gefitinib against gefitinib-resistant NSCLC by regulating the balance of angiogenic factors through HIF-1α/VEGF.
Song X, Wang L, Cai P, Xu Y, Liu Q, Fan D
Toxicology and applied pharmacology 2024 May;486:116938
Toxicology and applied pharmacology 2024 May;486:116938
Hypoxia inducible factor-1α facilitates transmissible gastroenteritis virus replication by inhibiting type I and type III interferon production.
Zhang Y, Rui X, Li Y, Zhang Y, Cai Y, Tan C, Yang N, Liu Y, Fu Y, Liu G
Veterinary microbiology 2024 May;292:110055
Veterinary microbiology 2024 May;292:110055
Prognostic biomarker HIF1α and its correlation with immune infiltration in gliomas.
Ding Z, Zhang J, Li L, Wang C, Mei J
Oncology letters 2024 May;27(5):193
Oncology letters 2024 May;27(5):193
Fluorinated hydroxyapatite conditions a favorable osteo-immune microenvironment via triggering metabolic shift from glycolysis to oxidative phosphorylation.
Chen K, Ha S, Xu L, Liu C, Liu Y, Wu X, Li Z, Wu S, Yang B, Chen Z
Journal of translational medicine 2024 May 8;22(1):437
Journal of translational medicine 2024 May 8;22(1):437
The Bufei Nashen pill inhibits the PI3K/AKT/HIF-1 signaling pathway to regulate extracellular matrix deposition and improve COPD progression.
Xinchong P, Changxi Z, Anni Z, Wenrui Y, Jingyun L, Xue S
Journal of ethnopharmacology 2024 May 30;:118390
Journal of ethnopharmacology 2024 May 30;:118390
The Bioactive Compounds of Epimedium and Their Potential Mechanism of Action in Treating Osteoporosis: A Network Pharmacology and Experimental Validation Study.
Dong H, Tang F, Zhao Z, Huang W, Wan X, Hong Z, Liu Y, Dong X, Chen S
Pharmaceuticals (Basel, Switzerland) 2024 May 29;17(6)
Pharmaceuticals (Basel, Switzerland) 2024 May 29;17(6)
Isthmin-1 promotes growth and progression of colorectal cancer through the interaction with EGFR and YBX-1.
Zhou X, Zhang K, Wang C, Teng Y, Yu P, Cai W, Gao W, Li M, Ding Y, Sun P, Chen F, Wang Y, Ma J, Maeshige N, Ma X, Li Q, Liang X, Zhang Y, Su D
Cancer letters 2024 May 28;590:216868
Cancer letters 2024 May 28;590:216868
Human Umbilical Cord Mesenchymal Stromal Cell-Derived Extracellular Vesicles Induce Fetal Wound Healing Features Revealed by Single-Cell RNA Sequencing.
Liu Y, Zhang M, Wang C, Chen H, Su D, Yang C, Tao Y, Lv X, Zhou Z, Li J, Liao Y, You J, Wang Z, Cheng F, Yang R
ACS nano 2024 May 28;18(21):13696-13713
ACS nano 2024 May 28;18(21):13696-13713
NREP, transcriptionally upregulated by HIF-1α, aggravates breast cancer cell growth and metastasis by promoting glycolysis.
Ruan Y, Qiao J, Wang J, Liu Z
Cell death discovery 2024 May 2;10(1):210
Cell death discovery 2024 May 2;10(1):210
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Fu Y, Yuan P, Zeng M, Zhang Q, Hou Y, Gao L, Wei Y, Zheng Y, Feng W, Zheng X
Heliyon 2024 May 15;10(9):e29807
Heliyon 2024 May 15;10(9):e29807
Resveratrol attenuates inflammation and fibrosis in rheumatoid arthritis-associated interstitial lung disease via the AKT/TMEM175 pathway.
Liu N, Fan X, Shao Y, Chen S, Wang T, Yao T, Chen X
Journal of translational medicine 2024 May 14;22(1):457
Journal of translational medicine 2024 May 14;22(1):457
The down-regulation of STC2 mRNA may serve as a biomarker for death from mechanical asphyxia.
Hu Y, Han L, Zhang H, Li W, Wu T, Ma J, Zhang D, Ma K, Xiao B, Yu Y, Xu H, Tian L, Liao X, Chen L
Legal medicine (Tokyo, Japan) 2024 Mar;67:102382
Legal medicine (Tokyo, Japan) 2024 Mar;67:102382
Lipocalin 2 (LCN2) confers acquired resistance to almonertinib in NSCLC through LCN2-MMP-9 signaling pathway.
Shi C, Wang C, Fu Z, Liu J, Zhou Y, Cheng B, Zhang C, Li S, Zhang Y
Pharmacological research 2024 Mar;201:107088
Pharmacological research 2024 Mar;201:107088
Light-Enhanced Hypoxia-Responsive Gene Editing for Hypoxia-Resistant Photodynamic and Immunotherapy.
Qu S, Ji Y, Fan L, Yan T, Zhu G, Song H, Yang K, Han X
Advanced healthcare materials 2024 Mar;13(7):e2302615
Advanced healthcare materials 2024 Mar;13(7):e2302615
TREM2 deficiency impairs the energy metabolism of Schwann cells and exacerbates peripheral neurological deficits.
Zhang N, Ji Q, Chen Y, Wen X, Shan F
Cell death & disease 2024 Mar 7;15(3):193
Cell death & disease 2024 Mar 7;15(3):193
Tetramethylpyrazine alleviates hypoxia-induced proliferation, migration, and inflammatory response of fibroblast-like synoviocytes via inhibiting the HIF-1α- circCDC42BPB pathway.
Zhang YJ, Chen LF, Li X, Chen JH, Tan ZK
Advances in rheumatology (London, England) 2024 Mar 6;64(1):19
Advances in rheumatology (London, England) 2024 Mar 6;64(1):19
Naked mole-rats have distinctive cardiometabolic and genetic adaptations to their underground low-oxygen lifestyles.
Faulkes CG, Eykyn TR, Miljkovic JL, Gilbert JD, Charles RL, Prag HA, Patel N, Hart DW, Murphy MP, Bennett NC, Aksentijevic D
Nature communications 2024 Mar 27;15(1):2204
Nature communications 2024 Mar 27;15(1):2204
FBXO22 promotes glioblastoma malignant progression by mediating VHL ubiquitination and degradation.
Shen Z, Dong T, Yong H, Deng C, Chen C, Chen X, Chen M, Chu S, Zheng J, Li Z, Bai J
Cell death discovery 2024 Mar 23;10(1):151
Cell death discovery 2024 Mar 23;10(1):151
Bi(2)S(3)/Ti(3)C(2)-TPP nano-heterostructures induced by near-infrared for photodynamic therapy combined with photothermal therapy on hypoxic tumors.
Jiang H, Sun J, Liu F, Zhao Y, Chen X, Dai C, Wen Z
Journal of nanobiotechnology 2024 Mar 20;22(1):123
Journal of nanobiotechnology 2024 Mar 20;22(1):123
Cancer-associated fibroblast-secreted FGF7 as an ovarian cancer progression promoter.
Feng S, Ding B, Dai Z, Yin H, Ding Y, Liu S, Zhang K, Lin H, Xiao Z, Shen Y
Journal of translational medicine 2024 Mar 15;22(1):280
Journal of translational medicine 2024 Mar 15;22(1):280
Sustained AhR activity programs memory fate of early effector CD8(+) T cells.
Zhang H, Yang Z, Yuan W, Liu J, Luo X, Zhang Q, Li Y, Chen J, Zhou Y, Lv J, Zhou N, Ma J, Tang K, Huang B
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 12;121(11):e2317658121
Proceedings of the National Academy of Sciences of the United States of America 2024 Mar 12;121(11):e2317658121
The Anti-Atherosclerotic Effects of Buyang Huanwu Decoction through M1 and M2 Macrophage Polarization in an ApoE Knockout Mouse Model.
Ji M, Mao L, Wei Y, Zhu B, Zhai Y, Zhou X, Tao W, Wang W, Wu H
Journal of physiological investigation 2024 Mar 1;67(2):79-87
Journal of physiological investigation 2024 Mar 1;67(2):79-87
Capsaicin Enhanced the Efficacy of Photodynamic Therapy Against Osteosarcoma via a Pro-Death Strategy by Inducing Ferroptosis and Alleviating Hypoxia.
Wang Y, Zhou X, Yao L, Hu Q, Liu H, Zhao G, Wang K, Zeng J, Sun M, Lv C
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2306916
Small (Weinheim an der Bergstrasse, Germany) 2024 Jun;20(26):e2306916
The human testis-enriched HSPA2 interacts with HIF-1α in epidermal keratinocytes, yet HIF-1α stability and HIF-1-dependent gene expression rely on the HSPA (HSP70) activity.
Sojka DR, Gogler A, Kania D, Vydra N, Wiecha K, Adamiec-Organiściok M, Wilk A, Chumak V, Matyśniak D, Scieglinska D
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119735
Biochimica et biophysica acta. Molecular cell research 2024 Jun;1871(5):119735
The Hydrophilic Metabolite UMP Alleviates Obesity Traits through a HIF2α-ACER2-Ceramide Signaling Axis.
Liu H, Wang P, Xu F, Nie Q, Yan S, Zhang Z, Zhang Y, Jiang C, Qin X, Pang Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(21):e2309525
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Jun;11(21):e2309525
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
Sphingosine d18:1 promotes nonalcoholic steatohepatitis by inhibiting macrophage HIF-2α.
Xia J, Chen H, Wang X, Chen W, Lin J, Xu F, Nie Q, Ye C, Zhong B, Zhao M, Yun C, Zeng G, Mao Y, Wen Y, Zhang X, Yan S, Wang X, Sun L, Liu F, Zhong C, Xia P, Jiang C, Rao H, Pang Y
Nature communications 2024 Jun 4;15(1):4755
Nature communications 2024 Jun 4;15(1):4755
Succinate promotes pulmonary fibrosis through GPR91 and predicts death in idiopathic pulmonary fibrosis.
He Y, Han Y, Zou L, Yao T, Zhang Y, Lv X, Jiang M, Long L, Li M, Cheng X, Jiang G, Peng Z, Tao L, Meng J, Xie W
Scientific reports 2024 Jun 22;14(1):14376
Scientific reports 2024 Jun 22;14(1):14376
The Role of TPM3 in Protecting Cardiomyocyte from Hypoxia-Induced Injury via Cytoskeleton Stabilization.
Huang K, Yang W, Shi M, Wang S, Li Y, Xu Z
International journal of molecular sciences 2024 Jun 20;25(12)
International journal of molecular sciences 2024 Jun 20;25(12)
Multiple roles for hypoxia inducible factor 1-alpha in airway epithelial cells during mucormycosis.
Kavaliauskas P, Gu Y, Hasin N, Graf KT, Alqarihi A, Shetty AC, McCracken C, Walsh TJ, Ibrahim AS, Bruno VM
Nature communications 2024 Jun 20;15(1):5282
Nature communications 2024 Jun 20;15(1):5282
MATN4 as a target gene of HIF-1α promotes the proliferation and metastasis of osteosarcoma.
Zhang L, Pan Y, Pan F, Huang S, Wang F, Zeng Z, Chen H, Tian X
Aging 2024 Jun 17;16(12):10462-10476
Aging 2024 Jun 17;16(12):10462-10476
Transmissible gastroenteritis virus induces inflammatory responses via RIG-I/NF-κB/HIF-1α/glycolysis axis in intestinal organoids and in vivo.
Zhang Y, Yang N, Li Y, Tan C, Cai Y, Rui X, Liu Y, Fu Y, Liu G
Journal of virology 2024 Jun 13;98(6):e0046124
Journal of virology 2024 Jun 13;98(6):e0046124
Aerobic exercise-induced HIF-1α upregulation in heart failure: exploring potential impacts on MCT1 and MPC1 regulation.
Xu L, Yang M, Wei A, Wei Z, Qin Y, Wang K, Li B, Chen K, Liu C, Li C, Wang T
Molecular medicine (Cambridge, Mass.) 2024 Jun 12;30(1):83
Molecular medicine (Cambridge, Mass.) 2024 Jun 12;30(1):83
Hypoxia-mediated attenuation of EGLN2 inhibition of the NF-κB signaling pathway leads to the formation of a loop between HIF-1α and MUC1-C promoting chemoresistance in bladder cancer.
Qing L, Li Q, Yang Y, Xu W, Wang Y, Li R, You C, Dong Z
Molecular carcinogenesis 2024 Jul;63(7):1303-1318
Molecular carcinogenesis 2024 Jul;63(7):1303-1318
Angiopoietin-like 4 is upregulated by amphiregulin and activates cell proliferation and migration through p38 kinase in head and neck squamous cell carcinoma.
Kumar A, Asiedu E, Hefni E, Armstrong C, Menon D, Ma T, Sands L, Mbadugha E, Sodhi A, Schneider A, Montaner S
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2024 Jul;53(6):366-375
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2024 Jul;53(6):366-375
Parkin deficiency promotes liver cancer metastasis by TMEFF1 transcription activation via TGF-β/Smad2/3 pathway.
Su Q, Wang JJ, Ren JY, Wu Q, Chen K, Tu KH, Zhang Y, Leong SW, Sarwar A, Han X, Zhang M, Dai WF, Zhang YM
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Acta pharmacologica Sinica 2024 Jul;45(7):1520-1529
Scavenger Receptor Class B Type I Deficiency Induces Iron Overload and Ferroptosis in Renal Tubular Epithelial Cells via Hypoxia-Inducible Factor-1α/Transferrin Receptor 1 Signaling Pathway.
Yang L, Liu Q, Lu Q, Xiao JJ, Fu AY, Wang S, Ni L, Hu JW, Yu H, Wu X, Zhang BF
Antioxidants & redox signaling 2024 Jul;41(1-3):56-73
Antioxidants & redox signaling 2024 Jul;41(1-3):56-73
PDK1 promotes breast cancer progression by enhancing the stability and transcriptional activity of HIF-1α.
Wei Y, Zhang D, Shi H, Qian H, Chen H, Zeng Q, Jin F, Ye Y, Ou Z, Guo M, Guo B, Chen T
Genes & diseases 2024 Jul;11(4):101041
Genes & diseases 2024 Jul;11(4):101041
Hypoxia-responsive lncRNA MIR155HG promotes PD-L1 expression in hepatocellular carcinoma cells by enhancing HIF-1α mRNA stability.
Qiu J, Zhong F, Zhang Z, Pan B, Ye D, Zhang X, Yao Y, Luo Y, Wang X, Tang N
International immunopharmacology 2024 Jul 30;136:112415
International immunopharmacology 2024 Jul 30;136:112415
AUY922 improves sensitivity to sunitinib in clear cell renal cell carcinoma based on network pharmacology and in vitro experiments.
Chen Z, Jia X, Cai Y, Song Y, Tong Y, Cheng S, Liu M
Heliyon 2024 Jul 30;10(14):e34834
Heliyon 2024 Jul 30;10(14):e34834
DEPDC1 as a metabolic target regulates glycolysis in renal cell carcinoma through AKT/mTOR/HIF1α pathway.
Di SC, Chen WJ, Yang W, Zhang XM, Dong KQ, Tian YJ, Sun Y, Qian C, Chen JX, Liu ZC, Gong ZX, Chu J, Zhou W, Pan XW, Cui XG
Cell death & disease 2024 Jul 27;15(7):533
Cell death & disease 2024 Jul 27;15(7):533
Single-cell transcriptomic insights into chemotherapy-induced remodeling of the osteosarcoma tumor microenvironment.
Zheng X, Wu W, Zhao Z, Zhang X, Yu S
Journal of cancer research and clinical oncology 2024 Jul 20;150(7):356
Journal of cancer research and clinical oncology 2024 Jul 20;150(7):356
Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma.
Zang Y, Wang A, Zhang J, Xia M, Jiang Z, Jia B, Lu C, Chen C, Wang S, Zhang Y, Wang C, Cao X, Niu Z, He C, Bai X, Tian S, Zhai G, Cao H, Chen Y, Zhang K
iScience 2024 Jul 19;27(7):110188
iScience 2024 Jul 19;27(7):110188
The ANGPTL4-HIF-1α loop: a critical regulator of renal interstitial fibrosis.
Li Y, Chen S, Yang Q, Liu X, Zhou W, Kang T, Wu W, Ou S
Journal of translational medicine 2024 Jul 11;22(1):649
Journal of translational medicine 2024 Jul 11;22(1):649
HIF-1α Contributes to Hypoxia-induced VSMC Proliferation and Migration by Regulating Autophagy in Type A Aortic Dissection.
Huang B, Chen N, Chen Z, Shen J, Zhang H, Wang C, Sun Y
Advanced biology 2024 Jan;8(1):e2300292
Advanced biology 2024 Jan;8(1):e2300292
Hypoxic microenvironment promotes dermal fibroblast migration and proliferation via a BNIP3-autophagy pathway.
Zhang C, Li H, Jiang M, Zhang Q, Chen J, Jia J, Zhang Z, Yu H, Zhang J, Zhang J
The FEBS journal 2024 Jan;291(2):358-375
The FEBS journal 2024 Jan;291(2):358-375
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Wang T, Chen S, Wang Z, Li S, Fei X, Wang T, Zhang M
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Quantitative Proteomics of Tissue-Infiltrating T Cells From CRC Patients Identified Lipocalin-2 Induces T-Cell Apoptosis and Promotes Tumor Cell Proliferation by Iron Efflux.
Che R, Wang Q, Li M, Shen J, Ji J
Molecular & cellular proteomics : MCP 2024 Jan;23(1):100691
Molecular & cellular proteomics : MCP 2024 Jan;23(1):100691
NRF2 interacts with distal enhancer and inhibits nitric oxide synthase 2 expression in KRAS-driven pancreatic cancer cells.
Di Giorgio E, Cortolezzis Y, Gualandi N, Agostini F, Rapozzi V, Xodo LE
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119606
Biochimica et biophysica acta. Molecular cell research 2024 Jan;1871(1):119606
Meta-analysis identifying gut microbial biomarkers of Qinghai-Tibet Plateau populations and the functionality of microbiota-derived butyrate in high-altitude adaptation.
Zhao H, Sun L, Liu J, Shi B, Zhang Y, Qu-Zong CR, Dorji T, Wang T, Yuan H, Yang J
Gut microbes 2024 Jan-Dec;16(1):2350151
Gut microbes 2024 Jan-Dec;16(1):2350151
A Self-Homing and Traceable Cardiac Patch Leveraging Ferumoxytol for Spatiotemporal Therapeutic Delivery.
Li M, Liu Y, Huang B, Zhou G, Pan M, Jin J, Wang F, Wang Y, Ren X, Xu B, Hu B, Gu N
ACS nano 2024 Jan 30;18(4):3073-3086
ACS nano 2024 Jan 30;18(4):3073-3086
HIF-1A as a prognostic biomarker related to invasion, migration and immunosuppression of cervical cancer.
Li Z, Wei R, Yao S, Meng F, Kong L
Heliyon 2024 Jan 30;10(2):e24664
Heliyon 2024 Jan 30;10(2):e24664
The HIF-1/ BNIP3 pathway mediates mitophagy to inhibit the pyroptosis of fibroblast-like synoviocytes in rheumatoid arthritis.
Hong Z, Wang H, Zhang T, Xu L, Zhai Y, Zhang X, Zhang F, Zhang L
International immunopharmacology 2024 Jan 25;127:111378
International immunopharmacology 2024 Jan 25;127:111378
HIF-1α/METTL1/m(7)G axis is involved in CRC response to hypoxia.
Mi S, Cai S, Xue M, Wu W
Biochemical and biophysical research communications 2024 Jan 22;693:149385
Biochemical and biophysical research communications 2024 Jan 22;693:149385
Inhibition of glioblastoma cell proliferation and invasion by the choline-kinase inhibitor JAS239 varies with cell type and hypoxia.
Louise Kelly C, Wydrzynska M, Phelan MM, Osharovich S, Delikatny EJ, Sée V, Poptani H
bioRxiv : the preprint server for biology 2024 Jan 20;
bioRxiv : the preprint server for biology 2024 Jan 20;
A mitophagy sensor PPTC7 controls BNIP3 and NIX degradation to regulate mitochondrial mass.
Sun Y, Cao Y, Wan H, Memetimin A, Cao Y, Li L, Wu C, Wang M, Chen S, Li Q, Ma Y, Dong M, Jiang H
Molecular cell 2024 Jan 18;84(2):327-344.e9
Molecular cell 2024 Jan 18;84(2):327-344.e9
Downregulation of TET2 Contributes to Nasal Polypogenesis Through Hypoxia-Inducible Factor 1α-Mediated Epithelial-to-Mesenchymal Transition.
Liu K, Xu Y
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77
Clinical and experimental otorhinolaryngology 2024 Feb;17(1):64-77
Resveratrol-laden mesoporous silica nanoparticles regulate the autophagy and apoptosis via ROS-mediated p38-MAPK/HIF-1a /p53 signaling in hypertrophic scar fibroblasts.
Zuo J, Ma S
Heliyon 2024 Feb 29;10(4):e24985
Heliyon 2024 Feb 29;10(4):e24985
DNA polymerase iota promotes EMT and metastasis of esophageal squamous cell carcinoma by interacting with USP7 to stabilize HIF-1α.
Gao A, Zhang M, Zhu SQ, Zou S, Chen H, Li X, He C, Zhou L, Mei Y, Ding W, Zhou J, Zhou Y, Cao Y
Cell death & disease 2024 Feb 24;15(2):171
Cell death & disease 2024 Feb 24;15(2):171
LINC02561 promotes metastasis in HCC via HIF1-α/NDRG1/UPF1 axis.
Li SN, Li MX, Guo WW, Zhang LR, Ding YH, Wu XJ
Gene 2024 Feb 20;896:148033
Gene 2024 Feb 20;896:148033
SERCA2 dysfunction triggers hypertension by interrupting mitochondrial homeostasis and provoking oxidative stress.
Wang Y, Wang M, Su H, Song J, Ren M, Hu P, Liu G, Tong X
Free radical biology & medicine 2024 Feb 20;212:284-294
Free radical biology & medicine 2024 Feb 20;212:284-294
E. Coli LPS-induced calcium signaling regulates the expression of hypoxia-inducible factor 1α in periodontal ligament fibroblasts in a non-hypoxia-dependent manner.
Yang X, Cai X, Lin J, Zheng Y, Liao Z, Lin W, He X, Zhang Y, Ren X, Liu C
International immunopharmacology 2024 Feb 15;128:111418
International immunopharmacology 2024 Feb 15;128:111418
BCLAF1 binds SPOP to stabilize PD-L1 and promotes the development and immune escape of hepatocellular carcinoma.
Yu Z, Wu X, Zhu J, Yan H, Li Y, Zhang H, Zhong Y, Lin M, Ye G, Li X, Jin J, Li K, Wang J, Zhuang H, Lin T, He J, Lu C, Xu Z, Zhang X, Li H, Jin X
Cellular and molecular life sciences : CMLS 2024 Feb 10;81(1):82
Cellular and molecular life sciences : CMLS 2024 Feb 10;81(1):82
HBOC alleviated tumour hypoxia during radiotherapy more intensely in large solid tumours than regular ones.
Xu Y, Zhu K, Wu J, Zheng S, Zhong R, Zhou W, Cao Y, Liu J, Wang H
Artificial cells, nanomedicine, and biotechnology 2024 Dec;52(1):1-14
Artificial cells, nanomedicine, and biotechnology 2024 Dec;52(1):1-14
USP28 promotes tumor progression and glycolysis by stabilizing PKM2/Hif1-α in cholangiocarcinoma.
Qiao Q, Wang J, Liu S, Chang J, Zhou T, Li C, Zhang Y, Jiang W, Chen Y, Xu X, Wu M, Li X
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2217-2231
Cellular oncology (Dordrecht, Netherlands) 2024 Dec;47(6):2217-2231
Targeted regulation of autophagy using sorafenib-loaded biomineralization nanoenzyme for enhanced photodynamic therapy of hepatoma.
Lu T, Liu Z, Qian R, Zhou Y, Li J, Zhang Q, Yang H, Lu W, Xin Y, Xie Z, Yan L, Wang S, Qi R, Zhang Z
Materials today. Bio 2024 Dec;29:101270
Materials today. Bio 2024 Dec;29:101270
Identification of potential characteristic genes in chronic skin infections through RNA sequencing and immunohistochemical analysis.
Cao H, Xiong W, Zeng M, Hu L, Xu Y, Zhong W, Hu Y
Experimental and therapeutic medicine 2024 Dec;28(6):432
Experimental and therapeutic medicine 2024 Dec;28(6):432
YAP1 Overexpression Enhances the Aerobic Glycolysis Process via Suppression of EGLN2 in Pancreatic Ductal Adenocarcinoma.
Hu P, Dou R, Qi Z, Liu G, Su Y
The journal of gene medicine 2024 Dec;26(12):e70006
The journal of gene medicine 2024 Dec;26(12):e70006
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Liu W, Dou C, Zhang C, Chen P, Zhang S, Wang R, Han Q, Zhao H, Li D
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Quercetin inhibits malignant progression of high metastatic advanced colon cancer in hypoxia via suppressing ROS and PI3K/AKT pathway.
Shang P, Yang J, Shao L, Sun C, Ji J, Wang X, Zheng Z, Guo X
Pharmaceutical science advances 2024 Dec;2:100057
Pharmaceutical science advances 2024 Dec;2:100057
Dual-activity nanozyme as an oxygen pump to alleviate tumor hypoxia and enhance photodynamic/ NIR-II photothermal therapy for sniping oral squamous cell carcinoma.
Li X, Hao M, Liu A, Li L, Nešić MD, Yang B, Liu W, Lin Q
Acta biomaterialia 2024 Dec;190:476-487
Acta biomaterialia 2024 Dec;190:476-487
DNMT3A loss drives a HIF-1-dependent synthetic lethality to HDAC6 inhibition in non-small cell lung cancer.
Zhang J, Zhao Y, Liang R, Zhou X, Wang Z, Yang C, Gao L, Zheng Y, Shao H, Su Y, Cui W, Jia L, Yang J, Wu C, Wang L
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5219-5234
Acta pharmaceutica Sinica. B 2024 Dec;14(12):5219-5234
Phytosesquiterpene lactones deregulate mitochondrial activity and phenotypes associated with triple-negative breast cancer metastasis.
Cheng YT, Chang DM, Tung YC, Hsiao PW, Nakagawa-Goto K, Shyur LF
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156226
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156226
HNRNPD/MAD2L2 axis facilitates lung adenocarcinoma progression and is a potential prognostic biomarker.
Gu Z, Ding W, Yuan S, Peng Y, Dong B, Gu Y, Li J, Chen Y, Wang K, Liu T, Han X, Li Y
Cellular signalling 2024 Dec;124:111443
Cellular signalling 2024 Dec;124:111443
Novel serous effusion-related risk models and biomarkers for predicting prognosis in T-cell lymphoma patients.
Shang J, Zhou X, Liu B, Hu S, Wang X
Annals of hematology 2024 Dec;103(12):5557-5572
Annals of hematology 2024 Dec;103(12):5557-5572
Hypoxia drives estrogen receptor β-mediated cell growth via transcription activation in non-small cell lung cancer.
Su Q, Chen K, Ren J, Zhang Y, Han X, Leong SW, Wang J, Wu Q, Tu K, Sarwar A, Zhang Y
Journal of molecular medicine (Berlin, Germany) 2024 Dec;102(12):1471-1484
Journal of molecular medicine (Berlin, Germany) 2024 Dec;102(12):1471-1484
DNMT1-driven methylation of RORA facilitates esophageal squamous cell carcinoma progression under hypoxia through SLC2A3.
Yao W, Shang L, Wang Y, Xu L, Bai Y, Feng M, Jia X, Wu S
Journal of translational medicine 2024 Dec 31;22(1):1167
Journal of translational medicine 2024 Dec 31;22(1):1167
EIF2S2 transcriptionally upregulates HIF1α to promote gastric cancer progression via activating PI3K/AKT/mTOR pathway.
Wang Z, Zhang Y, Xue Y, Huang W, Zhang H
Carcinogenesis 2024 Dec 30;45(12):916-927
Carcinogenesis 2024 Dec 30;45(12):916-927
Turning attention to tumor-host interface and focus on the peritumoral heterogeneity of glioblastoma.
Wang F, Dong J, Xu Y, Jin J, Xu Y, Yan X, Liu Z, Zhao H, Zhang J, Wang N, Hu X, Gao X, Xu L, Yang C, Ma S, Du J, Hu Y, Ji H, Hu S
Nature communications 2024 Dec 30;15(1):10885
Nature communications 2024 Dec 30;15(1):10885
The IL-10/STAT3 Axis Nasopharyngeal Carcinoma Cancer stem cell and radio resistance.
Wang LJ, Zhao Y, Wang YS, Xing L, Duan YJ, Zang HH
Scientific reports 2024 Dec 30;14(1):31943
Scientific reports 2024 Dec 30;14(1):31943
Transposable element exonization generates a reservoir of evolving and functional protein isoforms.
Arribas YA, Baudon B, Rotival M, Suárez G, Bonté PE, Casas V, Roubert A, Klein P, Bonnin E, Mchich B, Legoix P, Baulande S, Sadacca B, Diharce J, Waterfall JJ, Etchebest C, Carrascal M, Goudot C, Quintana-Murci L, Burbage M, Merlotti A, Amigorena S
Cell 2024 Dec 26;187(26):7603-7620.e22
Cell 2024 Dec 26;187(26):7603-7620.e22
A Targetable Secreted Neural Protein Drives Pancreatic Cancer Metastatic Colonization and HIF1α Nuclear Retention.
Yamaguchi N, Wu YG, Ravetch E, Takahashi M, Khan AG, Hayashi A, Mei W, Hsu D, Umeda S, de Stanchina E, Lorenz IC, Iacobuzio-Donahue CA, Tavazoie SF
Cancer discovery 2024 Dec 2;14(12):2489-2508
Cancer discovery 2024 Dec 2;14(12):2489-2508
F13B regulates angiogenesis and tumor progression in hepatocellular carcinoma via the HIF-1α/VEGF pathway.
Jiang D, Qi Z, Xu ZY, Li YR
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
Biomolecules & biomedicine 2024 Dec 11;25(1):189-209
Induction of Peroxiredoxin 1 by Hypoxia Promotes Cellular Autophagy and Cell Proliferation in Oral Leukoplakia via HIF-1α/BNIP3 Pathway.
Li J, Li W, Li L, Wang W, Zhang M, Tang X
Journal of molecular histology 2024 Aug;55(4):403-413
Journal of molecular histology 2024 Aug;55(4):403-413
High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.
Dai P, He J, Wei Y, Xu M, Zhao J, Zhou X, Tang H
Inflammation 2024 Aug;47(4):1248-1261
Inflammation 2024 Aug;47(4):1248-1261
Laponite/lactoferrin hydrogel loaded with eugenol for methicillin-resistant Staphylococcus aureus-infected chronic skin wound healing.
Zhou R, Zhang W, Zhang Y, Wu X, Huang J, Bo R, Liu M, Yu J, Li J
Journal of tissue viability 2024 Aug;33(3):487-503
Journal of tissue viability 2024 Aug;33(3):487-503
SENP1 reduces oxidative stress and apoptosis in renal ischaemia-reperfusion injury by deSUMOylation of HIF-1α.
Hui Y, Xia K, Zhong J, Zhang Y, Qiu Q, Chen Z, Wang L, Liu X
Journal of cellular and molecular medicine 2024 Aug;28(16):e70043
Journal of cellular and molecular medicine 2024 Aug;28(16):e70043
Erastin promotes random-pattern skin flaps survival by inducing mTORC1-TFEB mediated autophagy.
Chen X, Zhu X, Chen Y, Ruan Z, Zhang Y, Wu H, Zhang X, Gao W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116918
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:116918
Melatonin enhances the efficacy of anti-PD-L1 by improving hypoxia in residual tumors after insufficient radiofrequency ablation.
Ren Y, Zhu L, Guo Y, Ma J, Yang L, Zheng C, Dong X
Journal of pharmaceutical analysis 2024 Aug;14(8):100942
Journal of pharmaceutical analysis 2024 Aug;14(8):100942
Inhibition of Let-7b-5p maturation by LIN28A promotes thermal skin damage repair after burn injury.
Zhou S, Guo L, Cui X, Zhang X, Yang Y, Zhang M, Zhang P
Cellular signalling 2024 Aug;120:111217
Cellular signalling 2024 Aug;120:111217
Loss of Bcl-3 regulates macrophage polarization by promoting macrophage glycolysis.
Liu S, Wang H, Li J, Gao J, Yu L, Wei X, Cui M, Zhao Y, Liang Y, Wang H
Immunology and cell biology 2024 Aug;102(7):605-617
Immunology and cell biology 2024 Aug;102(7):605-617
A CLIC1 network coordinates matrix stiffness and the Warburg effect to promote tumor growth in pancreatic cancer.
Zheng JH, Zhu YH, Yang J, Ji PX, Zhao RK, Duan ZH, Yao HF, Jia QY, Yin YF, Hu LP, Li Q, Jiang SH, Huo YM, Liu W, Sun YW, Liu DJ
Cell reports 2024 Aug 27;43(8):114633
Cell reports 2024 Aug 27;43(8):114633
Carrier-Free Hybrid Nanoparticles for Enhanced Photodynamic Therapy in Oral Carcinoma via Reversal of Hypoxia and Oxidative Resistance.
Li X, Li Z, Su Y, Zhou J, Li Y, Zhao Q, Yang X, Shi L, Shen L
Pharmaceutics 2024 Aug 27;16(9)
Pharmaceutics 2024 Aug 27;16(9)
Therapeutic potential of flavopiridol in diabetic retinopathy: Targeting DDX58.
Zhang X, Hu Q, Peng H, Huang J, Sang W, Guan J, Huang Z, Jiang B, Sun D
International immunopharmacology 2024 Aug 20;137:112504
International immunopharmacology 2024 Aug 20;137:112504
FGD5 in basal cells induces CXCL14 secretion that initiates a feedback loop to promote murine mammary epithelial growth and differentiation.
Zhang T, Zhao C, Li Y, Wu J, Wang F, Yu J, Wang Z, Gao Y, Zhao L, Liu Y, Yan Y, Li X, Gao H, Hu Z, Cui B, Li K
Developmental cell 2024 Aug 19;59(16):2085-2100.e9
Developmental cell 2024 Aug 19;59(16):2085-2100.e9
Pilocarpine mediated excessive calcium accumulation leads to ciliary muscle cell senescence and apoptosis.
Gao X, Gao N, Du M, Xiang Y, Zuo H, Cao H, Zheng S, Huang R, Wan W, Hu K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23878
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Aug 15;38(15):e23878
Hypoxia-induced downregulation of PGK1 crotonylation promotes tumorigenesis by coordinating glycolysis and the TCA cycle.
Guo Z, Zhang Y, Wang H, Liao L, Ma L, Zhao Y, Yang R, Li X, Niu J, Chu Q, Fu Y, Li B, Yang C
Nature communications 2024 Aug 12;15(1):6915
Nature communications 2024 Aug 12;15(1):6915
The mechanism of extracellular CypB promotes glioblastoma adaptation to glutamine deprivation microenvironment.
Yin H, Liu Y, Dong Q, Wang H, Yan Y, Wang X, Wan X, Yuan G, Pan Y
Cancer letters 2024 Aug 10;597:216862
Cancer letters 2024 Aug 10;597:216862
Exploration of the underlying mechanism of Astragaloside III in attenuating immunosuppression via network pharmacology and vitro/vivo pharmacological validation.
He Y, Amer HM, Xu Z, Liu L, Wu S, He B, Liu J, Kai G
Journal of ethnopharmacology 2024 Aug 10;330:118235
Journal of ethnopharmacology 2024 Aug 10;330:118235
Hypoxia-inducible factor-1α contributes to the proliferation of cholesteatoma keratinocytes through regulating endothelin converting enzyme 1 expression.
Chen N, Xu L, Bi Z, Wu J
Laryngoscope investigative otolaryngology 2024 Apr;9(2):e1233
Laryngoscope investigative otolaryngology 2024 Apr;9(2):e1233
E3 ubiquitin ligase NEDD4L inhibits epithelial-mesenchymal transition by suppressing the β-catenin/HIF-1α positive feedback loop in chronic rhinosinusitis with nasal polyps.
Chen SY, Liu PQ, Qin DX, Lv H, Zhou HQ, Xu Y
Acta pharmacologica Sinica 2024 Apr;45(4):831-843
Acta pharmacologica Sinica 2024 Apr;45(4):831-843
Preclinical multi-physiologic monitoring of immediate-early responses to diverse treatment strategies in breast cancer by optoacoustic imaging.
Lin X, Yang C, Lv Y, Zhang B, Kan J, Li H, Tao J, Yang C, Li X, Liu Y
Journal of biophotonics 2024 Apr;17(4):e202300457
Journal of biophotonics 2024 Apr;17(4):e202300457
Tumor necrosis factor α-induced protein 8-like-2 controls microglia phenotype via metabolic reprogramming in BV2 microglial cells and responses to neuropathic pain.
Li Y, Yin C, Jiang J, Yang H, Zhang F, Xing Y, Wang W, Lu C
The international journal of biochemistry & cell biology 2024 Apr;169:106541
The international journal of biochemistry & cell biology 2024 Apr;169:106541
Single-cell RNA sequencing of pediatric renal tissues revealed the potential relationship between immunoglobulin A nephropathy and immunoglobulin A vasculitis with nephritis.
Ye Q, Meng H, Ye F, Fu H, Wang J, Liu F, Shen H, Bao Y, Feng C, Zhang X, Huang G, Xie Y, Zhu X, Zhao M, Guo G, Mao J
Clinical and translational medicine 2024 Apr;14(4):e1651
Clinical and translational medicine 2024 Apr;14(4):e1651
Inflammatory Fibroblast-Like Synoviocyte-Derived Exosomes Aggravate Osteoarthritis via Enhancing Macrophage Glycolysis.
Liu B, Xian Y, Chen X, Shi Y, Dong J, Yang L, An X, Shen T, Wu W, Ma Y, He Y, Gong W, Peng R, Lin J, Liu N, Guo B, Jiang Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2024 Apr;11(14):e2307338
Fusobacterium periodonticum BCT protein targeting glucose metabolism to promote the epithelial-mesenchymal transition of esophageal cancer cells by lactic acid.
Guo X, Wan P, Shen W, Sun M, Peng Z, Liao Y, Huang Y, Liu R
Journal of translational medicine 2024 Apr 30;22(1):401
Journal of translational medicine 2024 Apr 30;22(1):401
Pathophysiological Implications of Protein Lactylation in Pancreatic Epithelial Tumors.
Takata T, Nakamura A, Yasuda H, Miyake H, Sogame Y, Sawai Y, Hayakawa M, Mochizuki K, Nakao R, Ogata T, Ikoma H, Konishi E, Harada Y, Otsuji E, Itoh Y, Tanaka H
Acta histochemica et cytochemica 2024 Apr 25;57(2):57-66
Acta histochemica et cytochemica 2024 Apr 25;57(2):57-66
Integrating spatial transcriptomics and single-cell RNA-sequencing reveals the alterations in epithelial cells during nodular formation in benign prostatic hyperplasia.
Fei X, Liu J, Xu J, Jing H, Cai Z, Yan J, Wu Z, Li H, Wang Z, Shen Y
Journal of translational medicine 2024 Apr 23;22(1):380
Journal of translational medicine 2024 Apr 23;22(1):380
Suppression of hypoxia-induced CAV1 autophagic degradation enhances nanoalbumin-paclitaxel transcytosis and improves therapeutic activity in pancreatic cancer.
Bai X, Xiong J, Li L, Yu C, Sun C
European journal of pharmacology 2024 Apr 15;969:176431
European journal of pharmacology 2024 Apr 15;969:176431
ED-71 ameliorates bone regeneration in type 2 diabetes by reducing ferroptosis in osteoblasts via the HIF1α pathway.
Wang M, Liu Y, Gui H, Ma G, Li B, Zhang Z, Yu G, Wu A, Xu X, Zhang D
European journal of pharmacology 2024 Apr 15;969:176303
European journal of pharmacology 2024 Apr 15;969:176303
Cascade-Catalyzed Nanogel for Amplifying Starvation Therapy by Nitric Oxide-Mediated Hypoxia Alleviation.
Wang W, Niu Y, Zhang N, Wan Y, Xiao Y, Zhao L, Zhao B, Chen W, Huang D
ACS applied materials & interfaces 2024 Apr 10;16(14):17313-17322
ACS applied materials & interfaces 2024 Apr 10;16(14):17313-17322
Germline USP36 Mutation Confers Resistance to EGFR-TKIs by Upregulating MLLT3 Expression in Patients with Non-Small Cell Lung Cancer.
Guan S, Chen X, Wei Y, Wang F, Xie W, Chen Y, Liang H, Zhu X, Yang Y, Fang W, Huang Y, Zhao H, Zhang X, Liu S, Zhuang W, Huang M, Wang X, Zhang L
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Clinical cancer research : an official journal of the American Association for Cancer Research 2024 Apr 1;30(7):1382-1396
Wogonin Diminishes Radioresistance of Breast Cancer via Inhibition of the Nrf2/HIF-1[Formula: see text] Pathway.
Wang T, Wang P, Wang S, Ma Y, Zhao Z, Long F
The American journal of Chinese medicine 2023;51(8):2243-2262
The American journal of Chinese medicine 2023;51(8):2243-2262
The SARS-CoV-2 spike glycoprotein interacts with MAO-B and impairs mitochondrial energetics.
Pileggi CA, Parmar G, Elkhatib H, Stewart CM, Alecu I, Côté M, Bennett SAL, Sandhu JK, Cuperlovic-Culf M, Harper ME
Current research in neurobiology 2023;5:100112
Current research in neurobiology 2023;5:100112
MDM2 promotes cancer cell survival through regulating the expression of HIF-1α and pVHL in retinoblastoma.
Zhang S, Xu H, Li W, Ji J, Jin Q, Chen L, Gan Q, Tao Q, Chai Y
Pathology oncology research : POR 2023;29:1610801
Pathology oncology research : POR 2023;29:1610801
Slc6a13 Deficiency Attenuates Pasteurella multocida Infection-Induced Inflammation via Glycine-Inflammasome Signaling.
He F, Qiu Y, Wu X, Xia Y, Yang L, Wu C, Li P, Zhang R, Fang R, Li N, Peng Y
Journal of innate immunity 2023;15(1):107-121
Journal of innate immunity 2023;15(1):107-121
Large-Scale Identification of Lysine Crotonylation Reveals Its Potential Role in Oral Squamous Cell Carcinoma.
Yin X, Zhang H, Wei Z, Wang Y, Han S, Zhou M, Xu W, Han W
Cancer management and research 2023;15:1165-1179
Cancer management and research 2023;15:1165-1179
Hypoxia-induced miR-653 enhances colorectal cancer progression by targeting circSETD3/KLF6 axis.
Chen Q, Deng Q, Pan Y, Ding X, Liu J
Journal of Cancer 2023;14(1):163-173
Journal of Cancer 2023;14(1):163-173
Unveiling the role of hypoxic macrophage-derived exosomes in driving colorectal cancer progression.
Jiang J, Wang W, Zhu L, Shi B, Chen Y, Xia Y, Feng W, Yao W, Lu A, Zhang H
Frontiers in immunology 2023;14:1260638
Frontiers in immunology 2023;14:1260638
Diabetes mellitus induces a novel inflammatory network involving cancer progression: Insights from bioinformatic analysis and in vitro validation.
Tan Y, Kang J, Li H, Zhong A, Liu Y, Zhang Z, Huang R, Cheng X, Peng W
Frontiers in immunology 2023;14:1149810
Frontiers in immunology 2023;14:1149810
Thymoquinone affects the gemcitabine sensitivity of pancreatic cancer by regulating collagen via hypoxia inducible factor-1α.
Zhao Z, Liu L, Chen H, Li S, Guo Y, Hou X, Yang J
Frontiers in pharmacology 2023;14:1138265
Frontiers in pharmacology 2023;14:1138265
Occlusion preconditioned mice are resilient to hypobaric hypoxia-induced myocarditis and arrhythmias due to enhanced immunomodulation, metabolic homeostasis, and antioxidants defense.
Adzika GK, Mprah R, Rizvi R, Adekunle AO, Ndzie Noah ML, Wowui PI, Adzraku SY, Adu-Amankwaah J, Wang F, Lin Y, Fu L, Liu X, Xiang J, Sun H
Frontiers in immunology 2023;14:1124649
Frontiers in immunology 2023;14:1124649
Chronic intermittent hypobaric hypoxia ameliorates osteoporosis after spinal cord injury through balancing osteoblast and osteoclast activities in rats.
Zhang L, Yin Y, Guo J, Jin L, Hou Z
Frontiers in endocrinology 2023;14:1035186
Frontiers in endocrinology 2023;14:1035186
The Aurora kinase inhibitor AT9283 inhibits Burkitt lymphoma growth by regulating Warburg effect.
Jiang K, Bai L, Wang C, Xiao X, Cheng Z, Peng H, Liu S
PeerJ 2023;11:e16581
PeerJ 2023;11:e16581
MK8617 inhibits M1 macrophage polarization and inflammation via the HIF-1α/GYS1/UDPG/P2Y(14) pathway.
Qian L, Chen XQ, Kong D, Wang G, Cao Y, Xiao Y, Cao JY, Zou C
PeerJ 2023;11:e15591
PeerJ 2023;11:e15591
Expression of hypoxia-inducing factor-1α and matrix metalloproteinase-9 in the recipient parasylvian cortical arteries with different hemodynamic sources in adult moyamoya disease.
Luo M, Yu J, Xin C, Hu M, Tao T, Wan G, Chen J, Zhang J
Frontiers in surgery 2023;10:1080395
Frontiers in surgery 2023;10:1080395
Hypoxia caused by unilateral nasal obstruction decreases mandibular density in rats through inhibition of Cyp1a1 expression.
Xu Y, Wang Y, Xiao H, Li Y
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Sep;52(8):786-794
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology 2023 Sep;52(8):786-794
Tumor microenvironment-initiated lipid redox cycling for efficient triple-negative breast cancer therapy.
Zhou TJ, Wan X, Zhang MM, Liu DM, Huang LL, Xing L, Wang Y, Jiang HL
Biomaterials 2023 Sep;300:122205
Biomaterials 2023 Sep;300:122205
UBE2S promotes malignant properties via VHL/HIF-1α and VHL/JAK2/STAT3 signaling pathways and decreases sensitivity to sorafenib in hepatocellular carcinoma.
Wu J, Xu X, Wu S, Shi W, Zhang G, Cao Y, Wang Z, Wu J, Jiang C
Cancer medicine 2023 Sep;12(17):18078-18097
Cancer medicine 2023 Sep;12(17):18078-18097
Ginsenoside Rh4 delays skeletal muscle aging through SIRT1 pathway.
Zhu A, Duan Z, Chen Y, Zhu C, Fan D
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Sep;118:154906
Bioengineered "Molecular Glue"-Mediated Tumor-Specific Cascade Nanoreactors with Self-Destruction Ability for Enhanced Precise Starvation/Chemosynergistic Tumor Therapy.
Zhang Q, Xuan Q, Wang C, Shi C, Wang X, Ma T, Zhang W, Li H, Wang P, Chen C
ACS applied materials & interfaces 2023 Sep 6;15(35):41271-41286
ACS applied materials & interfaces 2023 Sep 6;15(35):41271-41286
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
IGF1R-phosphorylated PYCR1 facilitates ELK4 transcriptional activity and sustains tumor growth under hypoxia.
Zheng K, Sha N, Hou G, Leng Z, Zhao Q, Zhang L, He L, Xu M, Jiang Y, Chen T
Nature communications 2023 Sep 30;14(1):6117
Nature communications 2023 Sep 30;14(1):6117
Hypoxia-induced TMTC3 expression in esophageal squamous cell carcinoma potentiates tumor angiogenesis through Rho GTPase/STAT3/VEGFA pathway.
Yuan H, Zhao Z, Xu J, Zhang R, Ma L, Han J, Zhao W, Guo M, Song Y
Journal of experimental & clinical cancer research : CR 2023 Sep 26;42(1):249
Journal of experimental & clinical cancer research : CR 2023 Sep 26;42(1):249
Combining network pharmacology and in vitro and in vivo experiments to study the mechanism of Keluoxin in the treatment of radiation nephropathy†.
Deng L, Wang S, Leng X, Yao P, Li C, Zheng Y
Journal of radiation research 2023 Sep 22;64(5):769-782
Journal of radiation research 2023 Sep 22;64(5):769-782
Hypoxia-inducible factor upregulation by roxadustat attenuates drug reward by altering brain iron homoeostasis.
Yan P, Li N, Ma M, Liu Z, Yang H, Li J, Wan C, Gao S, Li S, Zheng L, Waddington JL, Xu L, Zhen X
Signal transduction and targeted therapy 2023 Sep 18;8(1):355
Signal transduction and targeted therapy 2023 Sep 18;8(1):355
Systems pharmacology reveals the mechanism of Astragaloside IV in improving immune activity on cyclophosphamide-induced immunosuppressed mice.
Yao J, Liu J, He Y, Liu L, Xu Z, Lin X, Liu N, Kai G
Journal of ethnopharmacology 2023 Sep 15;313:116533
Journal of ethnopharmacology 2023 Sep 15;313:116533
Cerebellin-2 promotes endothelial-mesenchymal transition in hypoxic pulmonary hypertension rats by activating NF-κB/HIF-1α/Twist1 pathway.
Wang EL, Zhang JJ, Luo FM, Fu MY, Li D, Peng J, Liu B
Life sciences 2023 Sep 1;328:121879
Life sciences 2023 Sep 1;328:121879
An extra-erythrocyte role of haemoglobin body in chondrocyte hypoxia adaption.
Zhang F, Zhang B, Wang Y, Jiang R, Liu J, Wei Y, Gao X, Zhu Y, Wang X, Sun M, Kang J, Liu Y, You G, Wei D, Xin J, Bao J, Wang M, Gu Y, Wang Z, Ye J, Guo S, Huang H, Sun Q
Nature 2023 Oct;622(7984):834-841
Nature 2023 Oct;622(7984):834-841
Astragaloside IV Inhibited Podocyte Pyroptosis in Diabetic Kidney Disease by Regulating SIRT6/HIF-1α Axis.
Zhang M, Liu W, Liu Y, Zhang Z, Hu Y, Sun D, Li S, Fang J
DNA and cell biology 2023 Oct;42(10):594-607
DNA and cell biology 2023 Oct;42(10):594-607
Cav3.2 T-Type calcium channels downregulation attenuates bone cancer pain induced by inhibiting IGF-1/HIF-1α signaling pathway in the rat spinal cord.
Liu Q, Lu Z, Ren H, Fu L, Wang Y, Bu H, Ma M, Ma L, Huang C, Wang J, Zang W, Cao J, Fan X
Journal of bone oncology 2023 Oct;42:100495
Journal of bone oncology 2023 Oct;42:100495
Degradation of HIF-1α induced by curcumol blocks glutaminolysis and inhibits epithelial-mesenchymal transition and invasion in colorectal cancer cells.
Bian Y, Yin G, Wang G, Liu T, Liang L, Yang X, Zhang W, Tang D
Cell biology and toxicology 2023 Oct;39(5):1957-1978
Cell biology and toxicology 2023 Oct;39(5):1957-1978
FTY-720 alleviates diabetes-induced liver injury by inhibiting oxidative stress and inflammation.
Ye H, Sun M, Jin Z, Yuan Y, Weng H
Fundamental & clinical pharmacology 2023 Oct;37(5):960-970
Fundamental & clinical pharmacology 2023 Oct;37(5):960-970
PDK4 facilitates fibroblast functions and diabetic wound healing through regulation of HIF-1α protein stability and gene expression.
Ma Z, Mo R, Yang P, Ding Y, Zhang H, Dong Z, Chen Y, Tan Q
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Oct;37(10):e23215
CircABPD1 alleviates oxidative lung injury of bronchopulmonary dysplasia through regulating miR-330-3p/HIF1α axis.
Li H, Ma K, Dou H, Liu L, Qian Y, Li S, Chen J, Han S, Gu X, Yin J
The international journal of biochemistry & cell biology 2023 Oct;163:106464
The international journal of biochemistry & cell biology 2023 Oct;163:106464
Ganoderma lucidum polysaccharide peptide (GLPP) attenuates rheumatic arthritis in rats through inactivating NF-κB and MAPK signaling pathways.
Meng M, Wang L, Yao Y, Lin D, Wang C, Yao J, Sun H, Liu M
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155010
The PRX-1/TLR4 axis promotes hypoxia-induced radiotherapy resistance in non-small cell lung cancer by targeting the NF-κB/p65 pathway.
Hao J, Song Z, Su J, Li L, Zou L, Zou K
Cellular signalling 2023 Oct;110:110806
Cellular signalling 2023 Oct;110:110806
Mechanism of the HIF-1α/VEGF/VEGFR-2 pathway in the proliferation and apoptosis of human haemangioma endothelial cells.
Zhang W, Sun L, Gao H, Wang S
International journal of experimental pathology 2023 Oct;104(5):258-268
International journal of experimental pathology 2023 Oct;104(5):258-268
Fasting mimicking diet inhibits tumor-associated macrophage survival and pro-tumor function in hypoxia: implications for combination therapy with anti-angiogenic agent.
Wang L, Wang YJ, Wang R, Gong FL, Shi YH, Li SN, Chen PP, Yuan YF
Journal of translational medicine 2023 Oct 26;21(1):754
Journal of translational medicine 2023 Oct 26;21(1):754
Sirtuin4 alleviates severe acute pancreatitis by regulating HIF-1α/HO-1 mediated ferroptosis.
Liu Y, Cui H, Mei C, Cui M, He Q, Wang Q, Li D, Song Y, Li J, Chen S, Zhu C
Cell death & disease 2023 Oct 21;14(10):694
Cell death & disease 2023 Oct 21;14(10):694
ERRα promotes glycolytic metabolism and targets the NLRP3/caspase-1/GSDMD pathway to regulate pyroptosis in endometrial cancer.
Su P, Mao X, Ma J, Huang L, Yu L, Tang S, Zhuang M, Lu Z, Osafo KS, Ren Y, Wang X, Lin X, Huang L, Huang X, Braicu EI, Sehouli J, Sun P
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
Journal of experimental & clinical cancer research : CR 2023 Oct 20;42(1):274
Pancreatic Ductal Adenocarcinoma: The Characteristics of Contrast-Enhanced Ultrasound Are Correlated with the Hypoxic Microenvironment.
Wang L, Li M, Dong T, Li Y, Yin C, Nie F
Diagnostics (Basel, Switzerland) 2023 Oct 20;13(20)
Diagnostics (Basel, Switzerland) 2023 Oct 20;13(20)
Evodiamine impairs HIF1A histone lactylation to inhibit Sema3A-mediated angiogenesis and PD-L1 by inducing ferroptosis in prostate cancer.
Yu Y, Huang X, Liang C, Zhang P
European journal of pharmacology 2023 Oct 15;957:176007
European journal of pharmacology 2023 Oct 15;957:176007
NARFL deficiency caused mitochondrial dysfunction in lung cancer cells by HIF-1α-DNMT1 axis.
Liu H, Wu X, Yang T, Wang C, Huang F, Xu Y, Peng J
Scientific reports 2023 Oct 11;13(1):17176
Scientific reports 2023 Oct 11;13(1):17176
Neutrophil extracellular traps boost laser-induced mouse choroidal neovascularization through the activation of the choroidal endothelial cell TLR4/HIF-1α pathway.
Zeng J, Wang Y, Zhu M, Wu M, Zhou Y, Wang Q, Xu Y, Lin F, Wang J, Li Y, Liang S, Wang Z, Xie L, Liu X
The FEBS journal 2023 Nov;290(22):5395-5410
The FEBS journal 2023 Nov;290(22):5395-5410
HIF‑1α and RACGAP1 promote the progression of hepatocellular carcinoma in a mutually regulatory way.
Wu X, Xu Z, Li W, Lu Y, Pu J
Molecular medicine reports 2023 Nov;28(5)
Molecular medicine reports 2023 Nov;28(5)
Dl-3-n-butylphthalide exerts neuroprotective effects by modulating hypoxia-inducible factor 1-alpha ubiquitination to attenuate oxidative stress-induced apoptosis.
Li S, Zhao J, Xi Y, Ren J, Zhu Y, Lu Y, Dong D
Neural regeneration research 2023 Nov;18(11):2424-2428
Neural regeneration research 2023 Nov;18(11):2424-2428
A positive feedback loop between miR-574-3p and HIF-1α in promoting angiogenesis under hypoxia.
Zhang R, Miao Z, Liu Y, Zhang X, Yang Q
Microvascular research 2023 Nov;150:104589
Microvascular research 2023 Nov;150:104589
Nuciferine protects against lipopolysaccharide-induced endometritis via inhibiting ferroptosis and modulating AMPKα/mTOR/HIF-1α signaling axis.
Jiang P, Zhao L, Hu R, Zhai Z, Guo J, Zhang K
International immunopharmacology 2023 Nov;124(Pt B):110914
International immunopharmacology 2023 Nov;124(Pt B):110914
Ferrostatin-1 attenuates hypoxic-ischemic brain damage in neonatal rats by inhibiting ferroptosis.
Zhang M, Liu Z, Zhou W, Shen M, Mao N, Xu H, Wang Y, Xu Z, Li M, Jiang H, Chen Y, Zhu J, Lin W, Yuan J, Lin Z
Translational pediatrics 2023 Nov 28;12(11):1944-1970
Translational pediatrics 2023 Nov 28;12(11):1944-1970
Hypoxia-induced PLOD2 promotes clear cell renal cell carcinoma progression via modulating EGFR-dependent AKT pathway activation.
Liu T, Xiang W, Chen Z, Wang G, Cao R, Zhou F, Meng Z, Luo Y, Chen L
Cell death & disease 2023 Nov 27;14(11):774
Cell death & disease 2023 Nov 27;14(11):774
The survivin-ran inhibitor LLP-3 decreases oxidative phosphorylation, glycolysis and growth of neuroblastoma cells.
Galiger C, Zohora FT, Dorneburg C, Tews D, Debatin KM, Beltinger C
BMC cancer 2023 Nov 25;23(1):1148
BMC cancer 2023 Nov 25;23(1):1148
Anti-infection effects of heparin on SARS-CoV-2 in a diabetic mouse model.
Zhang Z, Zhang N, Lu X, Zhou M, Yan X, Gu W, Yang J, Zhang Q, Zhang C, Gong Y, Jia M, Zhang X, Ning P, Liu M, Li X, Shi X, Liu W, Gao GF, Ning G, Wang J, Bi Y
Zoological research 2023 Nov 18;44(6):1003-1014
Zoological research 2023 Nov 18;44(6):1003-1014
JUN mediates glucocorticoid resistance by stabilizing HIF1a in T cell acute lymphoblastic leukemia.
Zhang Z, Shi J, Wu Q, Zhang Z, Liu X, Ren A, Zhao G, Dong G, Wu H, Zhao J, Zhao Y, Hu J, Li H, Zhang T, Zhou F, Zhu H
iScience 2023 Nov 17;26(11):108242
iScience 2023 Nov 17;26(11):108242
Hypoxia activation attenuates progesterone synthesis in goat trophoblast cells via NR1D1 inhibition of StAR expression†.
Li C, Yang D, Yang W, Wang Y, Li D, Li Y, Xiao B, Zhang H, Zhao H, Dong H, Zhang J, Chu G, Wang A, Jin Y, Liu Y, Chen H
Biology of reproduction 2023 Nov 15;109(5):720-735
Biology of reproduction 2023 Nov 15;109(5):720-735
PI3K/AKT signaling activates HIF1α to modulate the biological effects of invasive breast cancer with microcalcification.
Tian Y, Zhao L, Gui Z, Liu S, Liu C, Yu T, Zhang L
NPJ breast cancer 2023 Nov 13;9(1):93
NPJ breast cancer 2023 Nov 13;9(1):93
Lnc AC016727.1/BACH1/HIF-1 α signal loop promotes the progression of non-small cell lung cancer.
Zhang L, Liang J, Qin H, Lv Y, Liu X, Li Z, Chao Z, Jia C, Qin X, Zhang H
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Journal of experimental & clinical cancer research : CR 2023 Nov 10;42(1):296
Diagnosis of asphyxiation in advanced decomposed corpses by using Oil-Red-O Stain and immunohistochemical technology.
Reisinger C, Sölkner J, Risser DU, Seltenhammer MH
Legal medicine (Tokyo, Japan) 2023 May;62:102214
Legal medicine (Tokyo, Japan) 2023 May;62:102214
MSC-EXO and tempol ameliorate bronchopulmonary dysplasia in newborn rats by activating HIF-1α.
Wang J, Zhang A, Huang F, Xu J, Zhao M
Pediatric pulmonology 2023 May;58(5):1367-1379
Pediatric pulmonology 2023 May;58(5):1367-1379
The HIF-1α/miR-26a-5p/PFKFB3/ULK1/2 axis regulates vascular remodeling in hypoxia-induced pulmonary hypertension by modulation of autophagy.
Ma C, Xu Q, Huang S, Song J, Sun M, Zhang J, Chu G, Zhang B, Bai Y, Zhao X, Wang Z, Li P
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22906
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 May;37(5):e22906
Mechanism of piR-1245/PIWI-like protein-2 regulating Janus kinase-2/signal transducer and activator of transcription-3/vascular endothelial growth factor signaling pathway in retinal neovascularization.
Yu Y, Xia LK, Di Y, Nie QZ, Chen XL
Neural regeneration research 2023 May;18(5):1132-1138
Neural regeneration research 2023 May;18(5):1132-1138
Integrating HPLC-Q-TOF-MS/MS, network pharmacology and experimental validation to decipher the chemical substances and mechanism of modified Gui-shao-liu-jun-zi decoction against gastric cancer.
Huang W, Wen F, Ruan S, Gu P, Gu S, Song S, Zhou J, Li Y, Liu J, Shu P
Journal of traditional and complementary medicine 2023 May;13(3):245-262
Journal of traditional and complementary medicine 2023 May;13(3):245-262
Clinical and pathological features analysis of invasive breast cancer with microcalcification.
Tian Y, Zhao L, Gui Z, Liu S, Liu C, Yu T, Zhang L
Cancer medicine 2023 May;12(10):11351-11362
Cancer medicine 2023 May;12(10):11351-11362
Hypoxia disrupts the nasal epithelial barrier by inhibiting PTPN2 in chronic rhinosinusitis with nasal polyps.
Zhang M, Xiong Y, Tu J, Tang B, Zhang Z, Yu J, Shen L, Luo Q, Ye J
International immunopharmacology 2023 May;118:110054
International immunopharmacology 2023 May;118:110054
Eriocitrin attenuates sepsis-induced acute lung injury in mice by regulating MKP1/MAPK pathway mediated-glycolysis.
Li D, Yang L, Wang W, Song C, Xiong R, Pan S, Li N, Geng Q
International immunopharmacology 2023 May;118:110021
International immunopharmacology 2023 May;118:110021
TMT-based quantitative proteomic analysis of spheroid cells of endometrial cancer possessing cancer stem cell properties.
Cao M, Liu Z, You D, Pan Y, Zhang Q
Stem cell research & therapy 2023 May 4;14(1):119
Stem cell research & therapy 2023 May 4;14(1):119
Single-cell transcriptomics of human-skin-equivalent organoids.
Stabell AR, Lee GE, Jia Y, Wong KN, Wang S, Ling J, Nguyen SD, Sen GL, Nie Q, Atwood SX
Cell reports 2023 May 30;42(5):112511
Cell reports 2023 May 30;42(5):112511
DiDang decoction improves mitochondrial function and lipid metabolism via the HIF-1 signaling pathway to treat atherosclerosis and hyperlipidemia.
Wu X, Pan J, Yu JJ, Kang J, Hou S, Cheng M, Xu L, Gong L, Li Y
Journal of ethnopharmacology 2023 May 23;308:116289
Journal of ethnopharmacology 2023 May 23;308:116289
Effect of miR‑29a‑3p in exosomes on glioma cells by regulating the PI3K/AKT/HIF‑1α pathway.
Liu Z, Yang Z, He L
Molecular medicine reports 2023 Mar;27(3)
Molecular medicine reports 2023 Mar;27(3)
LncRNA FRMD6-AS1 promotes hepatocellular carcinoma cell migration and stemness by regulating SENP1/HIF-1α axis.
Sun W, Lei X, Lu Q, Wu Q, Ma Q, Huang D, Zhang Y
Pathology, research and practice 2023 Mar;243:154377
Pathology, research and practice 2023 Mar;243:154377
ROS-activated MAPK/ERK pathway regulates crosstalk between Nrf2 and Hif-1α to promote IL-17D expression protecting the intestinal epithelial barrier under hyperoxia.
Wang P, Li T, Niu C, Sun S, Liu D
International immunopharmacology 2023 Mar;116:109763
International immunopharmacology 2023 Mar;116:109763
Protein disulfide-isomerase A4 confers glioblastoma angiogenesis promotion capacity and resistance to anti-angiogenic therapy.
Tu Z, Wang C, Hu Q, Tao C, Fang Z, Lin L, Lei K, Luo M, Sheng Y, Long X, Li J, Wu L, Huang K, Zhu X
Journal of experimental & clinical cancer research : CR 2023 Mar 30;42(1):77
Journal of experimental & clinical cancer research : CR 2023 Mar 30;42(1):77
NPAS2 promotes aerobic glycolysis and tumor growth in prostate cancer through HIF-1A signaling.
Ma S, Chen Y, Quan P, Zhang J, Han S, Wang G, Qi R, Zhang X, Wang F, Yuan J, Yang X, Jia W, Qin W
BMC cancer 2023 Mar 28;23(1):280
BMC cancer 2023 Mar 28;23(1):280
KCNJ2/HIF1α positive-feedback loop promotes the metastasis of osteosarcoma.
Shen M, Pan R, Lei S, Zhang L, Zhou C, Zeng Z, Nie Y, Tian X
Cell communication and signaling : CCS 2023 Mar 2;21(1):46
Cell communication and signaling : CCS 2023 Mar 2;21(1):46
Platelet Lysate Therapy Attenuates Hypoxia Induced Apoptosis in Human Uroepithelial SV-HUC-1 Cells through Regulating the Oxidative Stress and Mitochondrial-Mediated Intrinsic Apoptotic Pathway.
Wu ZS, Luo HL, Chuang YC, Lee WC, Wang HJ, Chancellor MB
Biomedicines 2023 Mar 17;11(3)
Biomedicines 2023 Mar 17;11(3)
Hypoxia-Induced Kidney Injury in Newborn Rats.
Chu YT, Chen BH, Chen HH, Lee JC, Kuo TJ, Chiu HC, Lu WH
Toxics 2023 Mar 11;11(3)
Toxics 2023 Mar 11;11(3)
Decellularized brain extracellular matrix slice glioblastoma culture model recapitulates the interaction between cells and the extracellular matrix without a nutrient-oxygen gradient interference.
Wang C, Zhao Q, Zheng X, Li S, Chen J, Zhao H, Chen F, Cui L, Li W
Acta biomaterialia 2023 Mar 1;158:132-150
Acta biomaterialia 2023 Mar 1;158:132-150
Photodynamic therapy enhances the cytotoxicity of temozolomide against glioblastoma via reprogramming anaerobic glycolysis.
Li Y, Wang D, Zhang Z, Wang Y, Zhang Z, Liang Z, Liu F, Chen L
Photodiagnosis and photodynamic therapy 2023 Jun;42:103342
Photodiagnosis and photodynamic therapy 2023 Jun;42:103342
Loss of exosomal miR-200b-3p from hypoxia cancer-associated fibroblasts promotes tumorigenesis and reduces sensitivity to 5-Flourouracil in colorectal cancer via upregulation of ZEB1 and E2F3.
Gong W, Guo Y, Yuan H, Chai R, Wan Z, Zheng B, Hu X, Chen B, Gao S, Dai Q, Yu P, Tu S
Cancer gene therapy 2023 Jun;30(6):905-916
Cancer gene therapy 2023 Jun;30(6):905-916
De novo pyrimidine biosynthetic complexes support cancer cell proliferation and ferroptosis defence.
Yang C, Zhao Y, Wang L, Guo Z, Ma L, Yang R, Wu Y, Li X, Niu J, Chu Q, Fu Y, Li B
Nature cell biology 2023 Jun;25(6):836-847
Nature cell biology 2023 Jun;25(6):836-847
CBX7 Rejuvenates Late Passage Dental Pulp Stem Cells by Maintaining Stemness and Pro-angiogenic Ability.
Wu Y, Li B, Yu D, Zhou Z, Shen M, Jiang F
Tissue engineering and regenerative medicine 2023 Jun;20(3):473-488
Tissue engineering and regenerative medicine 2023 Jun;20(3):473-488
HPIP is an essential scaffolding protein running through the EGFR-RAS-ERK pathway and drives tumorigenesis.
Jiang Q, Zhang D, Liu J, Liang C, Yang R, Zhang C, Wu J, Lin J, Ye T, Ding L, Li J, Gao S, Li B, Ye Q
Science advances 2023 Jun 9;9(23):eade1155
Science advances 2023 Jun 9;9(23):eade1155
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Guo M, Zhu C, Fu R, Ma X, Duan Z, Fan D
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Alpha-ketoglutarate alleviates cadmium-induced inflammation by inhibiting the HIF1A-TNFAIP3 pathway in hepatocytes.
Jia Y, Yin C, Ke W, Liu J, Guo B, Wang X, Zhao P, Hu S, Zhang C, Li X, Liu R, Zheng X, Wang Y, Wang G, Pan H, Hu W, Song Z
The Science of the total environment 2023 Jun 20;878:163069
The Science of the total environment 2023 Jun 20;878:163069
Energy stress modulation of AMPK/FoxO3 signaling inhibits mitochondria-associated ferroptosis.
Zhong S, Chen W, Wang B, Gao C, Liu X, Song Y, Qi H, Liu H, Wu T, Wang R, Chen B
Redox biology 2023 Jul;63:102760
Redox biology 2023 Jul;63:102760
Type H vessel/platelet-derived growth factor receptor β(+) perivascular cell disintegration is involved in vascular injury and bone loss in radiation-induced bone damage.
Li J, Chen X, Ren L, Chen X, Wu T, Wang Y, Ren X, Cheng B, Xia J
Cell proliferation 2023 Jul;56(7):e13406
Cell proliferation 2023 Jul;56(7):e13406
Adipocytes promote pancreatic cancer migration and invasion through fatty acid metabolic reprogramming.
Cai Z, Li Y, Ma M, Wang L, Wang H, Liu M, Jiang C
Oncology reports 2023 Jul;50(1)
Oncology reports 2023 Jul;50(1)
PIEZO2 promotes cell proliferation and metastasis in colon carcinoma through the SLIT2/ROBO1/VEGFC pathway.
Shang H, Xu A, Yan H, Xu D, Zhang J, Fang X
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
Advances in clinical and experimental medicine : official organ Wroclaw Medical University 2023 Jul;32(7):763-776
5‑aminiolevulinic acid induces a radiodynamic effect with enhanced delayed reactive oxygen species production under hypoxic conditions in lymphoma cells: An in vitro study.
Suzuki K, Yamamoto J, Toh K, Miyaoka R
Experimental and therapeutic medicine 2023 Jul;26(1):360
Experimental and therapeutic medicine 2023 Jul;26(1):360
Immune-independent acquired resistance to PD-L1 antibody initiated by PD-L1 upregulation via PI3K/AKT signaling can be reversed by anlotinib.
Gao Y, Feng Y, Liu S, Zhang Y, Wang J, Qin T, Chen P, Li K
Cancer medicine 2023 Jul;12(14):15337-15349
Cancer medicine 2023 Jul;12(14):15337-15349
Ginkgo biloba extract attenuates cisplatin-induced renal interstitial fibrosis by inhibiting the activation of renal fibroblasts through down-regulating the HIF-1α/STAT3/IL-6 pathway in renal tubular epithelial cells.
Zhang Y, Qin X, Yang Y, Li J, Li X, Zou X, Huang Z, Huang S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154809
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jul;115:154809
Histone acetyltransferase P300 deficiency promotes ferroptosis of vascular smooth muscle cells by activating the HIF-1α/HMOX1 axis.
Shi J, Wang QH, Wei X, Huo B, Ye JN, Yi X, Feng X, Fang ZM, Jiang DS, Ma MJ
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91
Molecular medicine (Cambridge, Mass.) 2023 Jul 6;29(1):91
Two-in-One Polymeric NO-Donor Prodrugs Mediate Precision and Synergistic Prostate Cancer Treatment.
Zhao B, Wan Y, Zhou X, Zhang J, Chen J, Yang J, Liu Y, Chen W, Zhong Y, Qian H
ACS applied materials & interfaces 2023 Jul 19;15(28):33309-33321
ACS applied materials & interfaces 2023 Jul 19;15(28):33309-33321
Fibronectin promotes tumor angiogenesis and progression of non-small-cell lung cancer by elevating WISP3 expression via FAK/MAPK/ HIF-1α axis and activating wnt signaling pathway.
Zhou F, Sun J, Ye L, Jiang T, Li W, Su C, Ren S, Wu F, Zhou C, Gao G
Experimental hematology & oncology 2023 Jul 19;12(1):61
Experimental hematology & oncology 2023 Jul 19;12(1):61
Deciphering the Mechanism of Wogonin, a Natural Flavonoid, on the Proliferation of Pulmonary Arterial Smooth Muscle Cells by Integrating Network Pharmacology and In Vitro Validation.
Cui L, Zeng Z, Wang X, Yuan T, Wang C, Liu D, Guo J, Chen Y
Current issues in molecular biology 2023 Jan 8;45(1):555-570
Current issues in molecular biology 2023 Jan 8;45(1):555-570
EOAI, a ubiquitin-specific peptidase 5 inhibitor, prevents non-small cell lung cancer progression by inducing DNA damage.
Zheng Y, Wang L, Niu X, Guo Y, Zhao J, Li L, Zhao J
BMC cancer 2023 Jan 7;23(1):28
BMC cancer 2023 Jan 7;23(1):28
Hypoxia truncates and constitutively activates the key cholesterol synthesis enzyme squalene monooxygenase.
Coates HW, Capell-Hattam IM, Olzomer EM, Du X, Farrell R, Yang H, Byrne FL, Brown AJ
eLife 2023 Jan 19;12
eLife 2023 Jan 19;12
Iron metabolism disorder regulated by BMP signaling in hypoxic pulmonary hypertension.
Jiang Y, Guo Y, Feng X, Yang P, Liu Y, Dai X, Zhao F, Lei D, Li X, Liu Y, Li Y
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166589
Biochimica et biophysica acta. Molecular basis of disease 2023 Feb;1869(2):166589
Caprin-1 plays a role in cell proliferation and Warburg metabolism of esophageal carcinoma by regulating METTL3 and WTAP.
Gao Y, Yuan L, Ke C, Pei Z, Liu X, Wu R, Kui X, Zhang Y
Journal of translational medicine 2023 Feb 28;21(1):159
Journal of translational medicine 2023 Feb 28;21(1):159
Protective effects of pentoxifylline against chlorine-induced acute lung injury in rats.
Liu MM, Liu JZ, Zhao CQ, Guo P, Wang Z, Wu H, Yu W, Liu R, Hai CX, Zhang XD
BMC pharmacology & toxicology 2023 Feb 27;24(1):12
BMC pharmacology & toxicology 2023 Feb 27;24(1):12
Novel fusion protein PK5-RL-Gal-3C inhibits hepatocellular carcinoma via anti-angiogenesis and cytotoxicity.
Gao X, Jiang P, Wei X, Zhang W, Zheng J, Sun S, Yao H, Liu X, Zhang Q
BMC cancer 2023 Feb 15;23(1):154
BMC cancer 2023 Feb 15;23(1):154
Augmenting Intracellular Cargo Delivery of Extracellular Vesicles in Hypoxic Tissues through Inhibiting Hypoxia-Induced Endocytic Recycling.
Tong B, Liao Z, Liu H, Ke W, Lei C, Zhang W, Liang H, Wang H, He Y, Lei J, Yang K, Zhang X, Li G, Ma L, Song Y, Hua W, Feng X, Wang K, Wu X, Tan L, Gao Y, Yang C
ACS nano 2023 Feb 14;17(3):2537-2553
ACS nano 2023 Feb 14;17(3):2537-2553
Extracellular vesicle-derived circCEBPZOS attenuates postmyocardial infarction remodeling by promoting angiogenesis via the miR-1178-3p/PDPK1 axis.
Yu L, Liang Y, Zhang M, Yang PC, Hinek A, Mao S
Communications biology 2023 Feb 1;6(1):133
Communications biology 2023 Feb 1;6(1):133
Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway.
Liu J, Li L, Han X, Chen Y, Diao J
Pharmaceutical biology 2023 Dec;61(1):1332-1342
Pharmaceutical biology 2023 Dec;61(1):1332-1342
Hypoxia dissociates HDAC6/FOXO1 complex and aggregates them into nucleus to regulate autophagy and osteogenic differentiation.
Xu Y, Wang Y, Xiao H, Li Y
Journal of periodontal research 2023 Dec;58(6):1248-1260
Journal of periodontal research 2023 Dec;58(6):1248-1260
Estrogen receptor-related receptor γ uppresses hypoxia-induced angiogenesis by regulating VEGFA in endometrial cancer.
Wang XX, Hua T, Wang HB
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Dec;39(1):2264411
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2023 Dec;39(1):2264411
SND1, a novel co-activator of HIF1α, promotes tumor initiation in PyMT-induced breast tumor.
Hu L, Zeng Y, Xin L, Yang J
The FEBS journal 2023 Dec;290(24):5759-5772
The FEBS journal 2023 Dec;290(24):5759-5772
Pancreatic Acinar Cells-Derived Sphingosine-1-Phosphate Contributes to Fibrosis of Chronic Pancreatitis via Inducing Autophagy and Activation of Pancreatic Stellate Cells.
Wang D, Han S, Lv G, Hu Y, Zhuo W, Zeng Z, Tang J, Huang Y, Wang F, Wang J, Zhao Y, Zhao G
Gastroenterology 2023 Dec;165(6):1488-1504.e20
Gastroenterology 2023 Dec;165(6):1488-1504.e20
The interplay between H19 and HIF-1α in mitochondrial dysfunction in myocardial infarction.
Xie L, He J, Mao J, Zhang Q, Bo H, Li L
Cellular signalling 2023 Dec;112:110919
Cellular signalling 2023 Dec;112:110919
Exploration of the Pharmacological Mechanism of Vitexicarpin against Triple-Negative Breast Cancer in Network Pharmacology.
Wu T, Xiang M, Li Y, Gao Y, Teng D, Sun M, Guo W, Zhou Y
Frontiers in bioscience (Landmark edition) 2023 Dec 26;28(12):341
Frontiers in bioscience (Landmark edition) 2023 Dec 26;28(12):341
Dynamin-Related Protein 1 Binding Partners MiD49 and MiD51 Increased Mitochondrial Fission In Vitro and Atherosclerosis in High-Fat-Diet-Fed ApoE(-/-) Mice.
Ren J, Liu J, Zhang J, Hu X, Cui Y, Wei X, Ma Y, Li X, Zhao Y
International journal of molecular sciences 2023 Dec 23;25(1)
International journal of molecular sciences 2023 Dec 23;25(1)
Fluorinated Cell-Penetrating Peptide for Co-Delivering siHIF-1α and Sorafenib to Enhance In Vitro Anti-Tumor Efficacy.
Wan Y, Yang Y, Lai Q, Wang W, Wu M, Feng S
Pharmaceutics 2023 Dec 16;15(12)
Pharmaceutics 2023 Dec 16;15(12)
O(2)-Generating Fluorescent Carbon Dot-Decorated MnO(2) Nanosheets for "Off/On" MR/Fluorescence Imaging and Enhanced Photodynamic Therapy.
Xie M, Gao R, Li K, Kuang S, Wang X, Wen X, Lin X, Wan Y, Han C
ACS applied materials & interfaces 2023 Dec 13;15(49):56717-56732
ACS applied materials & interfaces 2023 Dec 13;15(49):56717-56732
Targeting metabolism by B-raf inhibitors and diclofenac restrains the viability of BRAF-mutated thyroid carcinomas with Hif-1α-mediated glycolytic phenotype.
Aprile M, Cataldi S, Perfetto C, Federico A, Ciccodicola A, Costa V
British journal of cancer 2023 Aug;129(2):249-265
British journal of cancer 2023 Aug;129(2):249-265
Hypoxia induces the production of epithelial-derived cytokines in eosinophilic chronic rhinosinusitis with nasal polyps.
Zhang M, Tang B, Huang L, Xiong Y, Tu J, Jia Y, Jiang F, Shen L, Luo Q, Ye J
International immunopharmacology 2023 Aug;121:110559
International immunopharmacology 2023 Aug;121:110559
Ginsenoside Rb1 inhibits ferroptosis to ameliorate hypoxic-ischemic brain damage in neonatal rats.
Zhang M, Lin W, Tao X, Zhou W, Liu Z, Zhang Z, Jin S, Zhang H, Teng C, Zhu J, Guo X, Lin Z
International immunopharmacology 2023 Aug;121:110503
International immunopharmacology 2023 Aug;121:110503
TSLP/TSLPR promotes renal fibrosis by activating STAT3 in renal fibroblasts.
Wang D, Wang F, Huang Y, Wang J, Luo H, Zhang P, Peng J, Tang G, Wang Y, Yu L, Ni D
International immunopharmacology 2023 Aug;121:110430
International immunopharmacology 2023 Aug;121:110430
IGF2BP3/HIF1A/YAP signaling plays a role in driving acute-on-chronic liver failure through activating hepatocyte reprogramming.
Cheng K, Liu S, Li C, Zhao Y, Wang Q
Cellular signalling 2023 Aug;108:110727
Cellular signalling 2023 Aug;108:110727
Hypoxic tumor-derived exosomal miR-21 induces cancer-associated fibroblast activation to promote head and neck squamous cell carcinoma metastasis.
Ye B, Duan Y, Zhou M, Wang Y, Lai Q, Yue K, Cao J, Wu Y, Wang X, Jing C
Cellular signalling 2023 Aug;108:110725
Cellular signalling 2023 Aug;108:110725
Radially Electrospun Fibrous Membrane Incorporated with Copper Peroxide Nanodots Capable of Self-Catalyzed Chemodynamic Therapy for Angiogenesis and Healing Acceleration of Diabetic Wounds.
Huang Y, Qi L, Liu Z, Jiang Y, Wang J, Liu L, Li Y, Zhang L, Feng G
ACS applied materials & interfaces 2023 Aug 2;15(30):35986-35998
ACS applied materials & interfaces 2023 Aug 2;15(30):35986-35998
Luteolin attenuates lupus nephritis by regulating macrophage oxidative stress via HIF-1α pathway.
Ding T, Yi T, Li Y, Zhang W, Wang X, Liu J, Fan Y, Ji J, Xu L
European journal of pharmacology 2023 Aug 15;953:175823
European journal of pharmacology 2023 Aug 15;953:175823
E3 ligase MAEA-mediated ubiquitination and degradation of PHD3 promotes glioblastoma progression.
Zhou P, Peng X, Tang S, Zhang K, Tan Z, Li D, Shen L, Peng J, Yang L
Oncogene 2023 Apr;42(16):1308-1320
Oncogene 2023 Apr;42(16):1308-1320
P4HA2-mediated HIF-1α stabilization promotes erdafitinib-resistance in FGFR3-alteration bladder cancer.
Li X, Li Y, Liu B, Chen L, Lyu F, Zhang P, He Q, Cheng L, Liu C, Song Y, Xing Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22840
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22840
Lactate modulates microglial inflammatory responses after oxygen-glucose deprivation through HIF-1α-mediated inhibition of NF-κB.
Zhang Y, Jia P, Wang K, Zhang Y, Lv Y, Fan P, Yang L, Zhang S, Wang T, Zhao J, Lv H, Chen X, Liu Y, Wei H, Zhang P
Brain research bulletin 2023 Apr;195:1-13
Brain research bulletin 2023 Apr;195:1-13
Silencing of OGDHL promotes liver cancer metastasis by enhancing hypoxia inducible factor 1 α protein stability.
Dai W, Li Y, Sun W, Ji M, Bao R, Chen J, Xu S, Dai Y, Chen Y, Liu W, Ge C, Sun W, Mo W, Guo C, Xu X
Cancer science 2023 Apr;114(4):1309-1323
Cancer science 2023 Apr;114(4):1309-1323
CPT1C-mediated fatty acid oxidation facilitates colorectal cancer cell proliferation and metastasis.
Li J, Zheng W, Wu J, Zhang J, Lv B, Li W, Liu J, Zhang X, Huang T, Luo Z
Acta biochimica et biophysica Sinica 2023 Apr 20;55(8):1301-1309
Acta biochimica et biophysica Sinica 2023 Apr 20;55(8):1301-1309
LINC00365 functions as a tumor suppressor by inhibiting HIF-1α-mediated glucose metabolism reprogramming in breast cancer.
Liu B, Qu X, Wang J, Xu L, Zhang L, Xu B, Su J, Bian X
Experimental cell research 2023 Apr 1;425(1):113514
Experimental cell research 2023 Apr 1;425(1):113514
IL-7-Treated Periodontal Ligament Cells Regulate Local Immune Homeostasis by Modulating Treg/Th17 Cell Polarization.
Yu XY, Zhang ZQ, Huang JC, Lin JY, Cai XP, Liu CF
Frontiers in medicine 2022;9:754341
Frontiers in medicine 2022;9:754341
HDAC5 inhibits ovarian angiogenesis in dehydroepiandrosterone-induced mouse model of polycystic ovary syndrome.
Wang Y, Wang Y, Chen Y, Gao Q, Hou L, Feng X
Folia histochemica et cytobiologica 2022;60(3):260-270
Folia histochemica et cytobiologica 2022;60(3):260-270
Salvianolic Acid Ameliorates Pressure Overload-Induced Cardiac Endothelial Dysfunction via Activating HIF1[Formula: see text]/HSF1/CD31 Pathway.
Li N, Hang W, Shu H, Wen Z, Ceesay BM, Zhou N
The American journal of Chinese medicine 2022;50(7):1869-1885
The American journal of Chinese medicine 2022;50(7):1869-1885
Bovine milk exosomes affected proliferation of macrophages under hypoxia.
Matic S, Dia VP
Current research in food science 2022;5:2108-2113
Current research in food science 2022;5:2108-2113
Effect of hydroxyapatite bioceramics on the growth of osteoblasts and HIF-α/VEGF signal axis in partial hypoxia environment in vitro.
Liu Y, Gan Z, Hu F
Technology and health care : official journal of the European Society for Engineering and Medicine 2022;30(S1):363-369
Technology and health care : official journal of the European Society for Engineering and Medicine 2022;30(S1):363-369
IL-22 Protects against Biliary Ischemia-Reperfusion Injury after Liver Transplantation via Activating STAT3 and Reducing Apoptosis and Oxidative Stress Levels In Vitro and In Vivo.
Bai Y, Wu H, Zhang J, Zhang S, Zhang Z, Wang H, Zhang Y, Shen Z
Oxidative medicine and cellular longevity 2022;2022:9635075
Oxidative medicine and cellular longevity 2022;2022:9635075
Lycopene Ameliorates Hypoxic Pulmonary Hypertension via Suppression of Oxidative Stress.
Wang D, Ji Y, Wang R, Cheng K, Liu L, Wu N, Tang Q, Zheng X, Li J, Zhu Z, Wang Q, Zhang X, Li R, Pan J, Sui Z, Yuan Y
Oxidative medicine and cellular longevity 2022;2022:9179427
Oxidative medicine and cellular longevity 2022;2022:9179427
Inhibition of KCTD10 Affects Diabetic Retinopathy Progression by Reducing VEGF and Affecting Angiogenesis.
Feng Y, Wang C, Wang G
Genetics research 2022;2022:4112307
Genetics research 2022;2022:4112307
Lignans from Mosla scabra Ameliorated Influenza A Virus-Induced Pneumonia via Inhibiting Macrophage Activation.
Cai W, Wu LR, Zhang SL
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1688826
Tissue Kallikrein Protects Rat Prostate against the Inflammatory Damage in a Chronic Autoimmune Prostatitis Model via Restoring Endothelial Function in a Bradykinin Receptor B2-Dependent Way.
Zhang M, Lin D, Luo C, Wei P, Cui K, Chen Z
Oxidative medicine and cellular longevity 2022;2022:1247806
Oxidative medicine and cellular longevity 2022;2022:1247806
ROS Promote Hypoxia-Induced Keratinocyte Epithelial-Mesenchymal Transition by Inducing SOX2 Expression and Subsequent Activation of Wnt/β-Catenin.
Shi Y, Wang S, Yang R, Wang Z, Zhang W, Liu H, Huang Y
Oxidative medicine and cellular longevity 2022;2022:1084006
Oxidative medicine and cellular longevity 2022;2022:1084006
A long-term high-fat diet influences brain damage and is linked to the activation of HIF-1α/AMPK/mTOR/p70S6K signalling.
Chen F, Yi WM, Wang SY, Yuan MH, Wen J, Li HY, Zou Q, Liu S, Cai ZY
Frontiers in neuroscience 2022;16:978431
Frontiers in neuroscience 2022;16:978431
Orexin-A Reverse Bone Mass Loss Induced by Chronic Intermittent Hypoxia Through OX1R-Nrf2/HIF-1α Pathway.
Gu H, Ru Y, Wang W, Cai G, Gu L, Ye J, Zhang WB, Wang L
Drug design, development and therapy 2022;16:2145-2160
Drug design, development and therapy 2022;16:2145-2160
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Hao M, Ding C, Sun S, Peng X, Liu W
Journal of inflammation research 2022;15:4921-4938
Journal of inflammation research 2022;15:4921-4938
Modified Qing' e Pills exerts anti-osteoporosis effects and prevents bone loss by enhancing type H blood vessel formation.
Lu J, Hu D, Ma C, Xu X, Shen L, Rong J, Zhao J, Shuai B
Frontiers in endocrinology 2022;13:998971
Frontiers in endocrinology 2022;13:998971
Dietary choline, via gut microbe- generated trimethylamine-N- oxide, aggravates chronic kidney disease-induced cardiac dysfunction by inhibiting hypoxia-induced factor 1α.
Xie F, Zhen X, Liu Z, Chen X, Liu Z, Zhou M, Zhou Z, Hu Z, Zhu F, Huang Q, Zhang L, Nie J
Frontiers in physiology 2022;13:996166
Frontiers in physiology 2022;13:996166
Exploring the pharmacological mechanisms of icaritin against nasopharyngeal carcinoma via network pharmacology and experimental validation.
Liu M, Hu T, Gou W, Chang H, Li Y, Li Y, Zuo D, Hou W, Jiao S
Frontiers in pharmacology 2022;13:993022
Frontiers in pharmacology 2022;13:993022
Dihydromyricetin-Encapsulated Liposomes Inhibit Exhaustive Exercise-Induced Liver Inflammation by Orchestrating M1/M2 Macrophage Polarization.
Zhou X, Yi L, Lang H, Zhang J, Zhang Q, Yu L, Zhu J, Mi M
Frontiers in pharmacology 2022;13:887263
Frontiers in pharmacology 2022;13:887263
Hypoxia-Induced Upregulation of lncRNA ELFN1-AS1 Promotes Colon Cancer Growth and Metastasis Through Targeting TRIM14 via Sponging miR-191-5p.
Jing X, Du L, Shi S, Niu A, Wu J, Wang Y, Wang C
Frontiers in pharmacology 2022;13:806682
Frontiers in pharmacology 2022;13:806682
Honokiol Inhibits HIF-1α-Mediated Glycolysis to Halt Breast Cancer Growth.
Yi X, Qi M, Huang M, Zhou S, Xiong J
Frontiers in pharmacology 2022;13:796763
Frontiers in pharmacology 2022;13:796763
WWOX-rs13338697 genotype predicts therapeutic efficacy of ADI-PEG 20 for patients with advanced hepatocellular carcinoma.
Chu YD, Liu HF, Chen YC, Chou CH, Yeh CT
Frontiers in oncology 2022;12:996820
Frontiers in oncology 2022;12:996820
Multitranscriptome analyses of keloid fibroblasts reveal the role of the HIF-1α/HOXC6/ERK axis in keloid development.
Wang Q, Zhong Y, Li Z, Zhu D, Lu H, Chen P, Li C, Peng X, Li Q, Zeng K
Burns & trauma 2022;10:tkac013
Burns & trauma 2022;10:tkac013
Transcriptional Repression of Aerobic Glycolysis by OVOL2 in Breast Cancer.
Zhang X, Luo F, Luo S, Li L, Ren X, Lin J, Liang Y, Ma C, Ding L, Zhang D, Ye T, Lin Y, Jin B, Gao S, Ye Q
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Sep;9(27):e2200705
HIF‑1α and MBP1 are associated with the progression of breast cancer cells by repressing β‑catenin transcription.
Zhuang Y, Li X, Zhan P, Pi G, Wen G
Oncology reports 2022 Sep;48(3)
Oncology reports 2022 Sep;48(3)
Inhibition of hypoxia-inducible factor 1 by acriflavine renders glioblastoma sensitive for photodynamic therapy.
Ma S, Wang F, Dong J, Wang N, Tao S, Du J, Hu S
Journal of photochemistry and photobiology. B, Biology 2022 Sep;234:112537
Journal of photochemistry and photobiology. B, Biology 2022 Sep;234:112537
Fraxinellone inhibits progression of glioblastoma via regulating the SIRT3 signaling pathway.
Shi J, Sun S, Xing S, Huang C, Huang Y, Wang Q, Xue X, Chen Z, Wang Y, Huang Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113416
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Sep;153:113416
Exercise protects intestinal epithelial barrier from high fat diet- induced permeabilization through SESN2/AMPKα1/HIF-1α signaling.
Yu C, Liu S, Niu Y, Fu L
The Journal of nutritional biochemistry 2022 Sep;107:109059
The Journal of nutritional biochemistry 2022 Sep;107:109059
Adipocyte-derived lactate is a signalling metabolite that potentiates adipose macrophage inflammation via targeting PHD2.
Feng T, Zhao X, Gu P, Yang W, Wang C, Guo Q, Long Q, Liu Q, Cheng Y, Li J, Cheung CKY, Wu D, Kong X, Xu Y, Ye D, Hua S, Loomes K, Xu A, Hui X
Nature communications 2022 Sep 5;13(1):5208
Nature communications 2022 Sep 5;13(1):5208
M(6)A RNA Methylation Mediates NOD1/NF-kB Signaling Activation in the Liver of Piglets Challenged with Lipopolysaccharide.
Xu M, Zhuo R, Tao S, Liang Y, Liu C, Liu Q, Wang T, Zhong X
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)
Antioxidants (Basel, Switzerland) 2022 Sep 30;11(10)
Small extracellular vesicles of hypoxic endothelial cells regulate the therapeutic potential of adipose-derived mesenchymal stem cells via miR-486-5p/PTEN in a limb ischemia model.
Shen Z, Wang W, Chen J, Chen B, Tang Y, Hou J, Li J, Liu S, Mei Y, Zhang L, Lu S
Journal of nanobiotechnology 2022 Sep 24;20(1):422
Journal of nanobiotechnology 2022 Sep 24;20(1):422
Regulatory mechanisms and function of hypoxia-induced long noncoding RNA NDRG1-OT1 in breast cancer cells.
Chao HH, Luo JL, Hsu MH, Chen LH, Lu TP, Tsai MH, Chuang EY, Chuang LL, Lai LC
Cell death & disease 2022 Sep 20;13(9):807
Cell death & disease 2022 Sep 20;13(9):807
Oleuropein ameliorated lung ischemia-reperfusion injury by inhibiting TLR4 signaling cascade in alveolar macrophages.
Xu Z, Sun X, Ding B, Zi M, Ma Y
Transplant immunology 2022 Oct;74:101664
Transplant immunology 2022 Oct;74:101664
Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.
Cai J, Liu J, Yan J, Lu X, Wang X, Li S, Mustafa K, Wang H, Xue Y, Mustafa M, Kantarci A, Xing Z
Journal of periodontal research 2022 Oct;57(5):1034-1042
Journal of periodontal research 2022 Oct;57(5):1034-1042
Environmental exposure to microcystin-LR increases the risks of urinary bladder proliferation and carcinogenesis: Evidence from case control, animal, and in vitro studies.
Pan C, Qin H, Jin H, Chen W, Guo H, Han X
Toxicology 2022 Oct;480:153326
Toxicology 2022 Oct;480:153326
Transgenic construction and functional miRNA analysis identify the role of miR-7 in prostate cancer suppression.
Wang C, Li W, Hu Q, Feng N, Liu C, Shi N, Chen S, Chen M, Guan H, You Z, Xu B
Oncogene 2022 Oct;41(41):4645-4657
Oncogene 2022 Oct;41(41):4645-4657
Inhibition of Hypoxia-Inducible Factor Prolyl-Hydroxylase Modulates Platelet Function.
Gu W, Qi J, Zhang S, Ding Y, Qiao J, Han Y
Thrombosis and haemostasis 2022 Oct;122(10):1693-1705
Thrombosis and haemostasis 2022 Oct;122(10):1693-1705
Reticulocalbin3: A Ca(2+) homeostasis regulator that promotes esophageal squamous cell carcinoma progression and cisplatin resistance.
Cai R, Wang P, Zhao X, Lu X, Deng R, Wang X, Hong C, Lin J
Cancer science 2022 Oct;113(10):3593-3607
Cancer science 2022 Oct;113(10):3593-3607
HOCI Probe CPP Induces the Differentiation of Human Dermal Fibroblasts into Vascular Endothelial Cells through PHD2/HIF-1α/HEY1 Signaling Pathway.
Cui X, Wen J, Li N, Hao X, Zhang S, Zhao B, Wu X, Miao J
Cells 2022 Oct 4;11(19)
Cells 2022 Oct 4;11(19)
Cancer cell autophagy, reprogrammed macrophages, and remodeled vasculature in glioblastoma triggers tumor immunity.
Chryplewicz A, Scotton J, Tichet M, Zomer A, Shchors K, Joyce JA, Homicsko K, Hanahan D
Cancer cell 2022 Oct 10;40(10):1111-1127.e9
Cancer cell 2022 Oct 10;40(10):1111-1127.e9
Ti(3) C(2) T(x) MXene Composite 3D Hydrogel Potentiates mTOR Signaling to Promote the Generation of Functional Hair Cells in Cochlea Organoids.
Zhang Z, Gao S, Hu YN, Chen X, Cheng C, Fu XL, Zhang SS, Wang XL, Che YW, Zhang C, Chai RJ
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(32):e2203557
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2022 Nov;9(32):e2203557
Cancer-associated fibroblast-secreted miR-421 promotes pancreatic cancer by regulating the SIRT3/H3K9Ac/HIF-1α axis.
Zhou B, Lei JH, Wang Q, Qu TF, Cha LC, Zhan HX, Liu SL, Hu X, Sun CD, Guo WD, Qiu FB, Cao JY
The Kaohsiung journal of medical sciences 2022 Nov;38(11):1080-1092
The Kaohsiung journal of medical sciences 2022 Nov;38(11):1080-1092
Engineered biomimetic nanoreactor for synergistic photodynamic-chemotherapy against hypoxic tumor.
Guo H, Wang L, Wu W, Guo M, Yang L, Zhang Z, Cao L, Pu F, Huang X, Shao Z
Journal of controlled release : official journal of the Controlled Release Society 2022 Nov;351:151-163
Journal of controlled release : official journal of the Controlled Release Society 2022 Nov;351:151-163
Biomimetic cell membrane-coated glucose/oxygen-exhausting nanoreactor for remodeling tumor microenvironment in targeted hypoxic tumor therapy.
Guo H, Zhang W, Wang L, Shao Z, Huang X
Biomaterials 2022 Nov;290:121821
Biomaterials 2022 Nov;290:121821
Panax notoginseng saponins alleviates inflammation induced by microglial activation and protects against ischemic brain injury via inhibiting HIF-1α/PKM2/STAT3 signaling.
Gao J, Yao M, Zhang W, Yang B, Yuan G, Liu JX, Zhang Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113479
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Nov;155:113479
Targeting APLN/APJ restores blood-testis barrier and improves spermatogenesis in murine and human diabetic models.
Song K, Yang X, An G, Xia X, Zhao J, Xu X, Wan C, Liu T, Zheng Y, Ren S, Wang M, Chang G, Cronin SJF, Penninger JM, Jing T, Ou X, Rao S, Liu Z, Zhao XY
Nature communications 2022 Nov 28;13(1):7335
Nature communications 2022 Nov 28;13(1):7335
Polarization and β-Glucan Reprogram Immunomodulatory Metabolism in Human Macrophages and Ex Vivo in Human Lung Cancer Tissues.
Fan TW, Daneshmandi S, Cassel TA, Uddin MB, Sledziona J, Thompson PT, Lin P, Higashi RM, Lane AN
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Journal of immunology (Baltimore, Md. : 1950) 2022 Nov 1;209(9):1674-1690
Sinensetin suppresses angiogenesis in liver cancer by targeting the VEGF/VEGFR2/AKT signaling pathway.
Li X, Li Y, Wang Y, Liu F, Liu Y, Liang J, Zhan R, Wu Y, Ren H, Zhang X, Liu J
Experimental and therapeutic medicine 2022 May;23(5):360
Experimental and therapeutic medicine 2022 May;23(5):360
Paeoniflorin alleviates the progression of retinal vein occlusion via inhibiting hypoxia inducible factor-1α/vascular endothelial growth factor/STAT3 pathway.
Kong L, Li J, Yang Y, Tang H, Zou H
Bioengineered 2022 May;13(5):13622-13631
Bioengineered 2022 May;13(5):13622-13631
A novel hypoxia-driven gene signature that can predict the prognosis of hepatocellular carcinoma.
Zeng Z, Lei S, Wang J, Yang Y, Lan J, Tian Q, Chen T, Hao X
Bioengineered 2022 May;13(5):12193-12210
Bioengineered 2022 May;13(5):12193-12210
Fabrication of a bio-instructive scaffold conferred with a favorable microenvironment allowing for superior implant osseointegration and accelerated in situ vascularized bone regeneration via type H vessel formation.
He Y, Wang W, Lin S, Yang Y, Song L, Jing Y, Chen L, He Z, Li W, Xiong A, Yeung KWK, Zhao Q, Jiang Y, Li Z, Pei G, Zhang ZY
Bioactive materials 2022 Mar;9:491-507
Bioactive materials 2022 Mar;9:491-507
RETRACTED: PINK1 deficiency in gastric cancer compromises mitophagy, promotes the Warburg effect, and facilitates M2 polarization of macrophages.
Xu Y, Lu J, Tang Y, Xie W, Zhang H, Wang B, Zhang S, Hou W, Zou C, Jiang P, Zhang W
Cancer letters 2022 Mar 31;529:19-36
Cancer letters 2022 Mar 31;529:19-36
Short isoform thymic stromal lymphopoietin reduces inflammation and aerobic glycolysis of asthmatic airway epithelium by antagonizing long isoform thymic stromal lymphopoietin.
Yu C, Huang W, Zhou Z, Liang S, Zhou Z, Liu J, Zhao H, Liu L, Dong H, Zou F, Cai S
Respiratory research 2022 Mar 29;23(1):75
Respiratory research 2022 Mar 29;23(1):75
microRNA-671-5p reduces tumorigenicity of ovarian cancer via suppressing HDAC5 and HIF-1α expression.
Peng D, Wu T, Wang J, Huang J, Zheng L, Wang P, Li J, Wu L, Luo M
Chemico-biological interactions 2022 Mar 1;355:109780
Chemico-biological interactions 2022 Mar 1;355:109780
Tanshinone IIA inhibits cell growth by suppressing SIX1-induced aerobic glycolysis in non-small cell lung cancer cells.
Qi H, Chen Z, Qin Y, Wang X, Zhang Z, Li Y
Oncology letters 2022 Jun;23(6):184
Oncology letters 2022 Jun;23(6):184
A reduced level of the long non-coding RNA SNHG8 activates the NF-kappaB pathway by releasing functional HIF-1alpha in a hypoxic inflammatory microenvironment.
Wang C, Yang Q, Han Y, Liu H, Wang Y, Huang Y, Zheng Y, Li W
Stem cell research & therapy 2022 Jun 3;13(1):229
Stem cell research & therapy 2022 Jun 3;13(1):229
Effects of endurance training on metabolic enzyme activity and transporter protein levels in the skeletal muscles of orchiectomized mice.
Takahashi K, Kitaoka Y, Hatta H
The journal of physiological sciences : JPS 2022 Jun 29;72(1):14
The journal of physiological sciences : JPS 2022 Jun 29;72(1):14
Inhibition of HIF-1α Attenuates Silica-Induced Pulmonary Fibrosis.
Xu X, Li Y, Niu Z, Xia J, Dai K, Wang C, Yao W, Guo Y, Deng X, He J, Deng M, Si H, Hao C
International journal of environmental research and public health 2022 Jun 1;19(11)
International journal of environmental research and public health 2022 Jun 1;19(11)
Dysregulation of iron homeostasis and methamphetamine reward behaviors in Clk1-deficient mice.
Yan PJ, Ren ZX, Shi ZF, Wan CL, Han CJ, Zhu LS, Li NN, Waddington JL, Zhen XC
Acta pharmacologica Sinica 2022 Jul;43(7):1686-1698
Acta pharmacologica Sinica 2022 Jul;43(7):1686-1698
Induction of cancer cell stemness in glioma through glycolysis and the long noncoding RNA HULC-activated FOXM1/AGR2/HIF-1α axis.
Li YP, Liu Y, Xiao LM, Chen LK, Tao EX, Zeng EM, Xu CH
Laboratory investigation; a journal of technical methods and pathology 2022 Jul;102(7):691-701
Laboratory investigation; a journal of technical methods and pathology 2022 Jul;102(7):691-701
LncRNA HOTTIP PROMOTES OVARIAN CANCER CELL INVASION AND METASTASIS BY STABILIZING HIF-1α IN THE ANOXIC CELLULAR MICROENVIRONMENT.
Zhang S, Ma Q, Wu X, Chen P
Acta endocrinologica (Bucharest, Romania : 2005) 2022 Jul-Sep;18(3):263-270
Acta endocrinologica (Bucharest, Romania : 2005) 2022 Jul-Sep;18(3):263-270
LGALS3BP in Microglia Promotes Retinal Angiogenesis Through PI3K/AKT Pathway During Hypoxia.
Zhao C, Liu Y, Meng J, Wang X, Liu X, Li W, Zhou Q, Xiang J, Li N, Hou S
Investigative ophthalmology & visual science 2022 Jul 8;63(8):25
Investigative ophthalmology & visual science 2022 Jul 8;63(8):25
Iron increases lipid deposition via oxidative stress-mediated mitochondrial dysfunction and the HIF1α-PPARγ pathway.
Song CC, Pantopoulos K, Chen GH, Zhong CC, Zhao T, Zhang DG, Luo Z
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
Cellular and molecular life sciences : CMLS 2022 Jul 4;79(7):394
A maternal high-fat diet induces fetal origins of NASH-HCC in mice.
Takiyama T, Sera T, Nakamura M, Hoshino M, Uesugi K, Horike SI, Meguro-Horike M, Bessho R, Takiyama Y, Kitsunai H, Takeda Y, Sawamoto K, Yagi N, Nishikawa Y, Takiyama Y
Scientific reports 2022 Jul 30;12(1):13136
Scientific reports 2022 Jul 30;12(1):13136
Bone marrow mesenchymal stem cells facilitate diabetic wound healing through the restoration of epidermal cell autophagy via the HIF-1α/TGF-β1/SMAD pathway.
Shi Y, Wang S, Zhang W, Zhu Y, Fan Z, Huang Y, Li F, Yang R
Stem cell research & therapy 2022 Jul 15;13(1):314
Stem cell research & therapy 2022 Jul 15;13(1):314
Sestrin2 induction contributes to anti-inflammatory responses and cell survival by globular adiponectin in macrophages.
Lee S, Pham DV, Park PH
Archives of pharmacal research 2022 Jan;45(1):38-50
Archives of pharmacal research 2022 Jan;45(1):38-50
Hsa_circ_0019054 up-regulates HIF1A through sequestering miR-340-5p to promote the tumorigenesis of intrahepatic cholangiocarcinoma.
Tang J, Tang R, Gu P, Han J, Huang W, Xue F
Human & experimental toxicology 2022 Jan-Dec;41:9603271221126494
Human & experimental toxicology 2022 Jan-Dec;41:9603271221126494
ROS/PI3K/Akt and Wnt/β-catenin signalings activate HIF-1α-induced metabolic reprogramming to impart 5-fluorouracil resistance in colorectal cancer.
Dong S, Liang S, Cheng Z, Zhang X, Luo L, Li L, Zhang W, Li S, Xu Q, Zhong M, Zhu J, Zhang G, Hu S
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Journal of experimental & clinical cancer research : CR 2022 Jan 8;41(1):15
Hypoxia-mediated YTHDF2 overexpression promotes lung squamous cell carcinoma progression by activation of the mTOR/AKT axis.
Xu P, Hu K, Zhang P, Sun ZG, Zhang N
Cancer cell international 2022 Jan 7;22(1):13
Cancer cell international 2022 Jan 7;22(1):13
Intraperitoneal Triamcinolone Reduces Postoperative Adhesions, Possibly through Alteration of Mitochondrial Function.
Purandare N, Kramer KJ, Minchella P, Ottum S, Walker C, Rausch J, Chao CR, Grossman LI, Aras S, Recanati MA
Journal of clinical medicine 2022 Jan 7;11(2)
Journal of clinical medicine 2022 Jan 7;11(2)
MiR-29a Curbs Hepatocellular Carcinoma Incidence via Targeting of HIF-1α and ANGPT2.
Huang YH, Lian WS, Wang FS, Wang PW, Lin HY, Tsai MC, Yang YL
International journal of molecular sciences 2022 Jan 31;23(3)
International journal of molecular sciences 2022 Jan 31;23(3)
Biodegradable oxygen-producing manganese-chelated metal organic frameworks for tumor-targeted synergistic chemo/photothermal/ photodynamic therapy.
Feng L, Chen M, Li R, Zhou L, Wang C, Ye P, Hu X, Yang J, Sun Y, Zhu Z, Fang K, Chai K, Shi S, Dong C
Acta biomaterialia 2022 Jan 15;138:463-477
Acta biomaterialia 2022 Jan 15;138:463-477
Ferroptosis-related gene NOX4, CHAC1 and HIF1A are valid biomarkers for stomach adenocarcinoma.
Xiao R, Wang S, Guo J, Liu S, Ding A, Wang G, Li W, Zhang Y, Bian X, Zhao S, Qiu W
Journal of cellular and molecular medicine 2022 Feb;26(4):1183-1193
Journal of cellular and molecular medicine 2022 Feb;26(4):1183-1193
Membrane progesterone receptor α (mPRα) enhances hypoxia-induced vascular endothelial growth factor secretion and angiogenesis in lung adenocarcinoma through STAT3 signaling.
Xia Z, Xiao J, Dai Z, Chen Q
Journal of translational medicine 2022 Feb 5;20(1):72
Journal of translational medicine 2022 Feb 5;20(1):72
The anti-MDR efficacy of YAN against A549/Taxol cells is associated with its inhibition on glycolysis and is further enhanced by 2-deoxy-d-glucose.
Gao M, Yang Y, Gao Y, Liu T, Guan Q, Zhou T, Shi Y, Hao M, Li Z, Zuo D, Zhang W, Wu Y
Chemico-biological interactions 2022 Feb 25;354:109843
Chemico-biological interactions 2022 Feb 25;354:109843
Frankincense myrrh attenuates hepatocellular carcinoma by regulating tumor blood vessel development through multiple epidermal growth factor receptor-mediated signaling pathways.
Zheng P, Huang Z, Tong DC, Zhou Q, Tian S, Chen BW, Ning DM, Guo YM, Zhu WH, Long Y, Xiao W, Deng Z, Lei YC, Tian XF
World journal of gastrointestinal oncology 2022 Feb 15;14(2):450-477
World journal of gastrointestinal oncology 2022 Feb 15;14(2):450-477
RNA sequence analysis reveals pathways and candidate genes associated with pancreatic acinar cells injury in a mouse pancreatitis model.
Chaoqun H, Rong Y, Yunpeng P, Xiaole Z, Wanli G, Chenyuan S, Dongya H, Yi M, Qiang L
Tissue & cell 2022 Dec;79:101940
Tissue & cell 2022 Dec;79:101940
Caveolin-1 suppresses hippocampal neuron apoptosis via the regulation of HIF1α in hypoxia in naked mole-rats.
Yang W, Wu W, Zhao Y, Li Y, Zhang C, Zhang J, Chen C, Cui S
Cell biology international 2022 Dec;46(12):2060-2074
Cell biology international 2022 Dec;46(12):2060-2074
Polydopamine-mediated graphene oxide and nanohydroxyapatite-incorporated conductive scaffold with an immunomodulatory ability accelerates periodontal bone regeneration in diabetes.
Li Y, Yang L, Hou Y, Zhang Z, Chen M, Wang M, Liu J, Wang J, Zhao Z, Xie C, Lu X
Bioactive materials 2022 Dec;18:213-227
Bioactive materials 2022 Dec;18:213-227
Nanoscale CaO(2) materials for synergistic transarterial chemoembolization in a VX2 orthotopic rabbit liver cancer model.
Wang Y, He X, Zhou C, Bai Y, Li T, Liu J, Ju S, Wang C, Xiang G, Xiong B
Acta biomaterialia 2022 Dec;154:536-548
Acta biomaterialia 2022 Dec;154:536-548
IL-8 exacerbates CCl(4)-induced liver fibrosis in human IL-8-expressing mice via the PI3K/Akt/HIF-1α pathway.
Ma Y, Bao Y, Wu L, Ke Y, Tan L, Ren H, Song J, Zhang Q, Jin Y
Molecular immunology 2022 Dec;152:111-122
Molecular immunology 2022 Dec;152:111-122
Protective effects of Gypenoside XVII against cerebral ischemia/reperfusion injury via SIRT1-FOXO3A- and Hif1a-BNIP3-mediated mitochondrial autophagy.
Xie W, Zhu T, Zhang S, Sun X
Journal of translational medicine 2022 Dec 27;20(1):622
Journal of translational medicine 2022 Dec 27;20(1):622
Stomatin-like protein-2 attenuates macrophage pyroptosis and H9c2 cells apoptosis by protecting mitochondrial function.
Fan R, Jiang H, Hu Y, Xu Y, Zhou Y, Chen G, Liu Y, Yao Y, Qin W, Chen W, Huang F, Chen X
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Biochemical and biophysical research communications 2022 Dec 25;636(Pt 1):112-120
Resveratrol Ameliorates Fibrosis in Rheumatoid Arthritis-Associated Interstitial Lung Disease via the Autophagy-Lysosome Pathway.
Bao L, Ye J, Liu N, Shao Y, Li W, Fan X, Zhao D, Wang H, Chen X
Molecules (Basel, Switzerland) 2022 Dec 2;27(23)
Molecules (Basel, Switzerland) 2022 Dec 2;27(23)
ACAP1 Deficiency Predicts Inferior Immunotherapy Response in Solid Tumors.
Yi Q, Pu Y, Chao F, Bian P, Lv L
Cancers 2022 Dec 1;14(23)
Cancers 2022 Dec 1;14(23)
An Original Aspirin-Containing Carbonic Anhydrase 9 Inhibitor Overcomes Hypoxia-Induced Drug Resistance to Enhance the Efficacy of Myocardial Protection.
Zhou W, Zhang B, Fan K, Yin X, Liu J, Gou S
Cardiovascular drugs and therapy 2022 Aug;36(4):605-618
Cardiovascular drugs and therapy 2022 Aug;36(4):605-618
Forkhead box A2 transcriptionally activates hsa-let-7 g to inhibit hypoxia-induced epithelial-mesenchymal transition by targeting c14orf28 in colorectal cancer.
Ouyang C, Fu Q, Xie Y, Xie J
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2022 Aug;23(3):188-194
Arab journal of gastroenterology : the official publication of the Pan-Arab Association of Gastroenterology 2022 Aug;23(3):188-194
High VHL Expression Reverses Warburg Phenotype and Enhances Immunogenicity in Kidney Tumor Cells.
Zhu S, Ding W, Chen Y, Wang W, Xu R, Liu C, Liu X, Deng H
Genomics, proteomics & bioinformatics 2022 Aug;20(4):657-669
Genomics, proteomics & bioinformatics 2022 Aug;20(4):657-669
Sirolimus increases the anti-cancer effect of Huai Er by regulating hypoxia inducible factor-1α-mediated glycolysis in hepatocellular carcinoma.
Zhou L, Zhao Y, Pan LC, Wang J, Shi XJ, Du GS, He Q
World journal of gastroenterology 2022 Aug 28;28(32):4600-4619
World journal of gastroenterology 2022 Aug 28;28(32):4600-4619
HIF-1α mediates renal fibrosis by regulating metabolic remodeling of renal tubule epithelial cells.
Liu D, Sun H, Li K, Zhao Z, Liu Z, Zhang G, Ge Y, Zhang J, Wang D, Leng Y
Biochemical and biophysical research communications 2022 Aug 27;618:15-23
Biochemical and biophysical research communications 2022 Aug 27;618:15-23
Global crotonylome reveals hypoxia-mediated lamin A crotonylation regulated by HDAC6 in liver cancer.
Zhang D, Tang J, Xu Y, Huang X, Wang Y, Jin X, Wu G, Liu P
Cell death & disease 2022 Aug 17;13(8):717
Cell death & disease 2022 Aug 17;13(8):717
Tubular epithelial cell-derived extracellular vesicles induce macrophage glycolysis by stabilizing HIF-1α in diabetic kidney disease.
Jia Y, Chen J, Zheng Z, Tao Y, Zhang S, Zou M, Yang Y, Xue M, Hu F, Li Y, Zhang Q, Xue Y, Zheng Z
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Molecular medicine (Cambridge, Mass.) 2022 Aug 12;28(1):95
Cell-Type Dependent Regulation of the Electrogenic Na(+)/HCO(3)(-) Cotransporter 1 (NBCe1) by Hypoxia and Acidosis in Glioblastoma.
Giannaki M, Ruf DE, Pfeifer E, Everaerts K, Heiland DH, Schnell O, Rose CR, Roussa E
International journal of molecular sciences 2022 Aug 11;23(16)
International journal of molecular sciences 2022 Aug 11;23(16)
Hypoxia-induced proteasomal degradation of DBC1 by SIAH2 in breast cancer progression.
Liu Q, Luo Q, Feng J, Zhao Y, Ma B, Cheng H, Zhao T, Lei H, Mu C, Chen L, Meng Y, Zhang J, Long Y, Su J, Chen G, Li Y, Hu G, Liao X, Chen Q, Zhu Y
eLife 2022 Aug 1;11
eLife 2022 Aug 1;11
Semaphorin 3A attenuates the hypoxia suppression of osteogenesis in periodontal ligament stem cells.
Chang X, Zhou F, Bu L, Wang N, Deng J, Wang S
Journal of periodontal research 2022 Apr;57(2):425-433
Journal of periodontal research 2022 Apr;57(2):425-433
TRIM7 suppresses cell invasion and migration through inhibiting HIF-1α accumulation in clear cell renal cell carcinoma.
Yuan C, Liu J, Liu L, Jia H, Gao Q, Wang X, Zhao J
Cell biology international 2022 Apr;46(4):554-567
Cell biology international 2022 Apr;46(4):554-567
Tumor-specific nitric oxide generator to amplify peroxynitrite based on highly penetrable nanoparticles for metastasis inhibition and enhanced cancer therapy.
Shi M, Zhang J, Wang Y, Peng C, Hu H, Qiao M, Zhao X, Chen D
Biomaterials 2022 Apr;283:121448
Biomaterials 2022 Apr;283:121448
SETD5 Regulates Glycolysis in Breast Cancer Stem-Like Cells and Fuels Tumor Growth.
Yang Z, Zhang C, Liu X, Che N, Feng Y, Xuan Y
The American journal of pathology 2022 Apr;192(4):712-721
The American journal of pathology 2022 Apr;192(4):712-721
Synthesis and evaluation of biarylquinoline derivatives as novel HIF-1α inhibitors.
Wu YC, Lu MT, Lin TH, Chu PC, Chang CS
Bioorganic chemistry 2022 Apr;121:105681
Bioorganic chemistry 2022 Apr;121:105681
CYLD deficiency enhances metabolic reprogramming and tumor progression in nasopharyngeal carcinoma via PFKFB3.
Wang L, Lin Y, Zhou X, Chen Y, Li X, Luo W, Zhou Y, Cai L
Cancer letters 2022 Apr 28;532:215586
Cancer letters 2022 Apr 28;532:215586
Metastatic Transition of Pancreatic Ductal Cell Adenocarcinoma Is Accompanied by the Emergence of Pro-Invasive Cancer-Associated Fibroblasts.
Liu S, Suhail Y, Novin A, Perpetua L, Kshitiz
Cancers 2022 Apr 28;14(9)
Cancers 2022 Apr 28;14(9)
Hypoxia Alters the Proteome Profile and Enhances the Angiogenic Potential of Dental Pulp Stem Cell-Derived Exosomes.
Li B, Xian X, Lin X, Huang L, Liang A, Jiang H, Gong Q
Biomolecules 2022 Apr 14;12(4)
Biomolecules 2022 Apr 14;12(4)
MFN2 knockdown promotes osteogenic differentiation of iPSC-MSCs through aerobic glycolysis mediated by the Wnt/β-catenin signaling pathway.
Deng L, Yi S, Yin X, Li Y, Luan Q
Stem cell research & therapy 2022 Apr 12;13(1):162
Stem cell research & therapy 2022 Apr 12;13(1):162
Notch1 activation of Jagged1 contributes to differentiation of mesenchymal stem cells into endothelial cells under cigarette smoke extract exposure.
Cheng Y, Gu W, Zhang G, Guo X
BMC pulmonary medicine 2022 Apr 11;22(1):139
BMC pulmonary medicine 2022 Apr 11;22(1):139
SLC25A38 as a novel biomarker for metastasis and clinical outcome in uveal melanoma.
Fan Z, Duan J, Luo P, Shao L, Chen Q, Tan X, Zhang L, Xu X
Cell death & disease 2022 Apr 11;13(4):330
Cell death & disease 2022 Apr 11;13(4):330
Lack of MOF Decreases Susceptibility to Hypoxia and Promotes Multidrug Resistance in Hepatocellular Carcinoma via HIF-1α.
Wang M, Liu H, Zhang X, Zhao W, Lin X, Zhang F, Li D, Xu C, Xie F, Wu Z, Yang Q, Li X
Frontiers in cell and developmental biology 2021;9:718707
Frontiers in cell and developmental biology 2021;9:718707
TMSB4 Overexpression Enhances the Potency of Marrow Mesenchymal Stromal Cells for Myocardial Repair.
Tang S, Fan C, Iroegbu CD, Zhou W, Zhang Z, Wu M, Chen W, Wu X, Peng J, Li Z, Yang J
Frontiers in cell and developmental biology 2021;9:670913
Frontiers in cell and developmental biology 2021;9:670913
miR-125b enhances metastasis and progression of cancer via the TXNIP and HIF1α pathway in pancreatic cancer.
Wang P, Zheng D, Qi H, Gao Q
Cancer biomarkers : section A of Disease markers 2021;31(1):27-38
Cancer biomarkers : section A of Disease markers 2021;31(1):27-38
NOX4-Derived ROS Mediates TGF-β1-Induced Metabolic Reprogramming during Epithelial-Mesenchymal Transition through the PI3K/AKT/HIF-1α Pathway in Glioblastoma.
Su X, Yang Y, Guo C, Zhang R, Sun S, Wang Y, Qiao Q, Fu Y, Pang Q
Oxidative medicine and cellular longevity 2021;2021:5549047
Oxidative medicine and cellular longevity 2021;2021:5549047
Retinal Neuropathy in IGT Stage of OLETF Rats: Another Characteristic Change of Diabetic Retinopathy.
Guo Z, Sun X, Yang J, Xie J, Zhong F, Li X, Zhang Y, Han F, Yang X, Yang S, Zhou W, Chang B
Journal of diabetes research 2021;2021:3181347
Journal of diabetes research 2021;2021:3181347
NEDD4L-induced β-catenin ubiquitination suppresses the formation and progression of interstitial pulmonary fibrosis via inhibiting the CTHRC1/HIF-1α axis.
Chen L, Yang Y, Yan H, Peng X, Zou J
International journal of biological sciences 2021;17(13):3320-3330
International journal of biological sciences 2021;17(13):3320-3330
Downregulation of RAB7 and Caveolin-1 increases MMP-2 activity in renal tubular epithelial cells under hypoxic conditions.
Yu W, Ke X, Li M, Ye P, Peng J, Li H
Open medicine (Warsaw, Poland) 2021;16(1):1428-1437
Open medicine (Warsaw, Poland) 2021;16(1):1428-1437
LncRNA IGFL2-AS1 Promotes the Proliferation, Migration, and Invasion of Colon Cancer Cells and is Associated with Patient Prognosis.
Cen X, Huang Y, Lu Z, Shao W, Zhuo C, Bao C, Feng S, Wei C, Tang X, Cen L, Guo W, Tian X, Tang Q, Huang X
Cancer management and research 2021;13:5957-5968
Cancer management and research 2021;13:5957-5968
Dextran Sulfate Effects EMT of Human Gastric Cancer Cells by Reducing HIF-1α/ TGF-β.
Huang YN, Xu YY, Ma Q, Li MQ, Guo JX, Wang X, Jin X, Shang J, Jiao LX
Journal of Cancer 2021;12(11):3367-3377
Journal of Cancer 2021;12(11):3367-3377
Inhibition of SPATS2 Suppresses Proliferation and Invasion of Hepatocellular Carcinoma Cells through TRIM44-STAT3 Signaling Pathway.
Chen L, Yi C, Li W, Tseng Y, Zhang J, Liu J
Journal of Cancer 2021;12(1):89-98
Journal of Cancer 2021;12(1):89-98
Claudin-5 Affects Endothelial Autophagy in Response to Early Hypoxia.
Yu P, Li Y, Zhong G, Li W, Chen B, Zhang J
Frontiers in physiology 2021;12:737474
Frontiers in physiology 2021;12:737474
Qian Yang Yu Yin Granule Improves Renal Injury of Hypertension by Regulating Metabolic Reprogramming Mediated by HIF-1α/PKM2 Positive Feedback Loop.
Qian L, Ren S, Xu Z, Zheng Y, Wu L, Yang Y, Wang Y, Li J, Yan S, Fang Z
Frontiers in pharmacology 2021;12:667433
Frontiers in pharmacology 2021;12:667433
A novel role of kallikrein-related peptidase 8 in the pathogenesis of diabetic cardiac fibrosis.
Du JK, Yu Q, Liu YJ, Du SF, Huang LY, Xu DH, Ni X, Zhu XY
Theranostics 2021;11(9):4207-4231
Theranostics 2021;11(9):4207-4231
A Mitochondrial DNA Variant Elevates the Risk of Gallstone Disease by Altering Mitochondrial Function.
Sun D, Niu Z, Zheng HX, Wu F, Jiang L, Han TQ, Wei Y, Wang J, Jin L
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
Cellular and molecular gastroenterology and hepatology 2021;11(4):1211-1226.e15
P4HA1 as an unfavorable prognostic marker promotes cell migration and invasion of glioblastoma via inducing EMT process under hypoxia microenvironment.
Zhu X, Liu S, Yang X, Wang W, Shao W, Ji T
American journal of cancer research 2021;11(2):590-617
American journal of cancer research 2021;11(2):590-617
Autophagy-Induced HDAC6 Activity During Hypoxia Regulates Mitochondrial Energy Metabolism Through the β-Catenin/COUP-TFII Axis in Hepatocellular Carcinoma Cells.
Yan X, Qu X, Liu B, Zhao Y, Xu L, Yu S, Wang J, Wang L, Su J
Frontiers in oncology 2021;11:742460
Frontiers in oncology 2021;11:742460
Artesunate Suppresses Choroidal Melanoma Vasculogenic Mimicry Formation and Angiogenesis via the Wnt/CaMKII Signaling Axis.
Geng B, Zhu Y, Yuan Y, Bai J, Dou Z, Sui A, Luo W
Frontiers in oncology 2021;11:714646
Frontiers in oncology 2021;11:714646
GRK6 Depletion Induces HIF Activity in Lung Adenocarcinoma.
Yao S, Ertay A, Zhou Y, Yao L, Hill C, Chen J, Guan Y, Sun H, Ewing RM, Liu Y, Lv X, Wang Y
Frontiers in oncology 2021;11:654812
Frontiers in oncology 2021;11:654812
Biochanin A Inhibits Glioblastoma Growth via Restricting Glycolysis and Mitochondrial Oxidative Phosphorylation.
Dong Q, Li Q, Duan L, Yin H, Wang X, Liu Y, Wang B, Li K, Yao X, Yuan G, Pan Y
Frontiers in oncology 2021;11:652008
Frontiers in oncology 2021;11:652008
IL-1β Promotes Vasculogenic Mimicry of Breast Cancer Cells Through p38/MAPK and PI3K/Akt Signaling Pathways.
Nisar MA, Zheng Q, Saleem MZ, Ahmmed B, Ramzan MN, Ud Din SR, Tahir N, Liu S, Yan Q
Frontiers in oncology 2021;11:618839
Frontiers in oncology 2021;11:618839
Hypoxic colorectal cancer-secreted exosomes deliver miR-210-3p to normoxic tumor cells to elicit a protumoral effect.
Ge L, Zhou F, Nie J, Wang X, Zhao Q
Experimental biology and medicine (Maywood, N.J.) 2021 Sep;246(17):1895-1906
Experimental biology and medicine (Maywood, N.J.) 2021 Sep;246(17):1895-1906
Mitochondrial calcium uniporter promotes cell proliferation and migration in esophageal cancer.
Miao Y, Wang X, Lai Y, Lin W, Huang Y, Yin H, Hou R, Zhang F
Oncology letters 2021 Sep;22(3):686
Oncology letters 2021 Sep;22(3):686
LncRNA ZNFTR functions as an inhibitor in pancreatic cancer by modulating ATF3/ZNF24/VEGFA pathway.
Li W, Han S, Hu P, Chen D, Zeng Z, Hu Y, Xu F, Tang J, Wang F, Zhao Y, Huang M, Zhao G
Cell death & disease 2021 Sep 3;12(9):830
Cell death & disease 2021 Sep 3;12(9):830
Assessing the protective effects of cryptotanshinone on CoCl(2)‑induced hypoxia in RPE cells.
Gu Y, Liu W, Liu G, Li X, Lu P
Molecular medicine reports 2021 Oct;24(4)
Molecular medicine reports 2021 Oct;24(4)
Dihydroartemisinin regulates lipid droplet metabolism in hepatic stellate cells by inhibiting lncRNA-H19-induced AMPK signal.
Xia S, Wang Z, Chen L, Zhou Y, Li Y, Wang S, Chen A, Xu X, Shao J, Zhang Z, Tan S, Zhang F, Zheng S
Biochemical pharmacology 2021 Oct;192:114730
Biochemical pharmacology 2021 Oct;192:114730
PPARα agonist WY-14,643 induces adipose atrophy and fails to blunt chronic ethanol-induced hepatic fat accumulation in mice lacking adipose FGFR1.
Xu Y, Denning KL, Lu Y
Biochemical pharmacology 2021 Oct;192:114678
Biochemical pharmacology 2021 Oct;192:114678
Photothermal and Enhanced Photocatalytic Therapies Conduce to Synergistic Anticancer Phototherapy with Biodegradable Titanium Diselenide Nanosheets.
Duo Y, Luo G, Li Z, Chen Z, Li X, Jiang Z, Yu B, Huang H, Sun Z, Yu XF
Small (Weinheim an der Bergstrasse, Germany) 2021 Oct;17(40):e2103239
Small (Weinheim an der Bergstrasse, Germany) 2021 Oct;17(40):e2103239
Panax notoginseng saponins reduces the cisplatin-induced acute renal injury by increasing HIF-1α/BNIP3 to inhibit mitochondrial apoptosis pathway.
Li Q, Zhang Y, Yang Y, Huang S, Zou X, Wei C, Liang T, Zhong X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 Oct;142:111965
Hypoxic tubular epithelial cells regulate the angiogenesis of HMEC-1 cells via mediation of Rab7/MMP-2 axis.
Yang Y, Wang J, Zhang Y, Hu X, Li L, Chen P
Aging 2021 Oct 25;13(20):23769-23779
Aging 2021 Oct 25;13(20):23769-23779
Overexpression of HIF-1α enhances the protective effect of mitophagy on steroid-induced osteocytes apoptosis.
Xu K, Lu C, Ren X, Wang J, Xu P, Zhang Y
Environmental toxicology 2021 Nov;36(11):2123-2137
Environmental toxicology 2021 Nov;36(11):2123-2137
PLGA/β-TCP composite scaffold incorporating cucurbitacin B promotes bone regeneration by inducing angiogenesis.
Cheng WX, Liu YZ, Meng XB, Zheng ZT, Li LL, Ke LQ, Li L, Huang CS, Zhu GY, Pan HD, Qin L, Wang XL, Zhang P
Journal of orthopaedic translation 2021 Nov;31:41-51
Journal of orthopaedic translation 2021 Nov;31:41-51
2-Deoxy-D-glucose impedes T cell-induced apoptosis of keratinocytes in oral lichen planus.
Wang F, Zhang J, Zhou G
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Journal of cellular and molecular medicine 2021 Nov;25(21):10257-10267
Ultrathin 2D Titanium Carbide MXene (Ti(3) C(2) T(x) ) Nanoflakes Activate WNT/HIF-1α-Mediated Metabolism Reprogramming for Periodontal Regeneration.
Cui D, Kong N, Ding L, Guo Y, Yang W, Yan F
Advanced healthcare materials 2021 Nov;10(22):e2101215
Advanced healthcare materials 2021 Nov;10(22):e2101215
NOX4-derived ROS-induced overexpression of FOXM1 regulates aerobic glycolysis in glioblastoma.
Su X, Yang Y, Yang Q, Pang B, Sun S, Wang Y, Qiao Q, Guo C, Liu H, Pang Q
BMC cancer 2021 Nov 5;21(1):1181
BMC cancer 2021 Nov 5;21(1):1181
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Tang L, Wang F, Xiao L, Shen M, Xia S, Zhang Z, Zhang F, Zheng S, Tan S
Journal of ethnopharmacology 2021 Nov 15;280:114411
Journal of ethnopharmacology 2021 Nov 15;280:114411
Silencing CTNND1 Mediates Triple-Negative Breast Cancer Bone Metastasis via Upregulating CXCR4/CXCL12 Axis and Neutrophils Infiltration in Bone.
Lin Q, Fang X, Liang G, Luo Q, Cen Y, Shi Y, Jia S, Li J, Yang W, Sanders AJ, Gong C, Jiang W
Cancers 2021 Nov 15;13(22)
Cancers 2021 Nov 15;13(22)
33-kDa ANXA3 isoform contributes to hepatocarcinogenesis via modulating ERK, PI3K/Akt-HIF and intrinsic apoptosis pathways.
Guo C, Li N, Dong C, Wang L, Li Z, Liu Q, Ma Q, Greenaway FT, Tian Y, Hao L, Liu S, Sun MZ
Journal of advanced research 2021 May;30:85-102
Journal of advanced research 2021 May;30:85-102
The DpdtbA induced EMT inhibition in gastric cancer cell lines was through ferritinophagy-mediated activation of p53 and PHD2/hif-1α pathway.
Guan D, Li C, Li Y, Li Y, Wang G, Gao F, Li C
Journal of inorganic biochemistry 2021 May;218:111413
Journal of inorganic biochemistry 2021 May;218:111413
Ginsenoside CK Inhibits Hypoxia-Induced Epithelial-Mesenchymal Transformation through the HIF-1α/NF-κB Feedback Pathway in Hepatocellular Carcinoma.
Zhang J, Ma X, Fan D
Foods (Basel, Switzerland) 2021 May 26;10(6)
Foods (Basel, Switzerland) 2021 May 26;10(6)
A HIF1A/miR-485-5p/SRPK1 axis modulates the aggressiveness of glioma cells upon hypoxia.
Cheng L, Peng R, Guo P, Zhang H, Liu D, Liao X, Liu Y, Mo X, Liao Y
Experimental cell research 2021 May 1;402(1):112547
Experimental cell research 2021 May 1;402(1):112547
Trim47 overexpression correlates with poor prognosis in gastric cancer.
Xia Y, Wei Z, Huang W, Wei X, He Y
Neoplasma 2021 Mar;68(2):307-316
Neoplasma 2021 Mar;68(2):307-316
The Expression and Role of Hypoxia-induced Factor-1α in Human Tenon's Capsule Fibroblasts under Hypoxia.
Qin X, Wu K, Zuo C, Lin M
Current eye research 2021 Mar;46(3):417-425
Current eye research 2021 Mar;46(3):417-425
SETD7 mediates the vascular invasion in articular cartilage and chondrocytes apoptosis in osteoarthriis.
Xiaoshi J, Maoquan L, Jiwei W, Jinqiu N, Ke Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21283
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Mar;35(3):e21283
YEATS2 is a target of HIF1α and promotes pancreatic cancer cell proliferation and migration.
Zeng Z, Lei S, He Z, Chen T, Jiang J
Journal of cellular physiology 2021 Mar;236(3):2087-2098
Journal of cellular physiology 2021 Mar;236(3):2087-2098
The essential role of PRAK in tumor metastasis and its therapeutic potential.
Wang Y, Wang W, Wu H, Zhou Y, Qin X, Wang Y, Wu J, Sun XY, Yang Y, Xu H, Qian X, Pang X, Li Y, Zhang Z, Han J, Zhang Y
Nature communications 2021 Mar 19;12(1):1736
Nature communications 2021 Mar 19;12(1):1736
p97/VCP is highly expressed in the stem-like cells of breast cancer and controls cancer stemness partly through the unfolded protein response.
Li C, Huang Y, Fan Q, Quan H, Dong Y, Nie M, Wang J, Xie F, Ji J, Zhou L, Zheng Z, Wang L
Cell death & disease 2021 Mar 17;12(4):286
Cell death & disease 2021 Mar 17;12(4):286
High expression of NDRG3 in osteoarthritis patients.
Chen L, Wang Y, Li S, Zhou W, Sun L
Arthroplasty (London, England) 2021 Mar 1;3(1):1
Arthroplasty (London, England) 2021 Mar 1;3(1):1
Marein ameliorates Ang II/hypoxia-induced abnormal glucolipid metabolism by modulating the HIF-1α/PPARα/γ pathway in H9c2 cells.
Niu G, Zhou M, Wang F, Yang J, Huang J, Zhu Z
Drug development research 2021 Jun;82(4):523-532
Drug development research 2021 Jun;82(4):523-532
A HIF1α-GPD1 feedforward loop inhibits the progression of renal clear cell carcinoma via mitochondrial function and lipid metabolism.
Liu R, Feng Y, Deng Y, Zou Z, Ye J, Cai Z, Zhu X, Liang Y, Lu J, Zhang H, Luo Y, Han Z, Zhuo Y, Xie Q, Hon CT, Liang Y, Wu CL, Zhong W
Journal of experimental & clinical cancer research : CR 2021 Jun 7;40(1):188
Journal of experimental & clinical cancer research : CR 2021 Jun 7;40(1):188
STAT3/HIF-1α signaling activation mediates peritoneal fibrosis induced by high glucose.
Yang X, Bao M, Fang Y, Yu X, Ji J, Ding X
Journal of translational medicine 2021 Jun 30;19(1):283
Journal of translational medicine 2021 Jun 30;19(1):283
Thioredoxin-interacting protein is a favored target of miR-125b, promoting metastasis and progression of pancreatic cancer via the HIF1α pathway.
Wang P, Zheng D, Qi H, Gao Q
Journal of biochemical and molecular toxicology 2021 Jul;35(7):e22782
Journal of biochemical and molecular toxicology 2021 Jul;35(7):e22782
Cynaroside prevents macrophage polarization into pro-inflammatory phenotype and alleviates cecal ligation and puncture-induced liver injury by targeting PKM2/HIF-1α axis.
Pei L, Le Y, Chen H, Feng J, Liu Z, Zhu J, Wang C, Chen L, Dou X, Lu D
Fitoterapia 2021 Jul;152:104922
Fitoterapia 2021 Jul;152:104922
USP19 promotes hypoxia-induced mitochondrial division via FUNDC1 at ER-mitochondria contact sites.
Chai P, Cheng Y, Hou C, Yin L, Zhang D, Hu Y, Chen Q, Zheng P, Teng J, Chen J
The Journal of cell biology 2021 Jul 5;220(7)
The Journal of cell biology 2021 Jul 5;220(7)
Oxygen-dependent changes in binding partners and post-translational modifications regulate the abundance and activity of HIF-1α/2α.
Daly LA, Brownridge PJ, Batie M, Rocha S, Sée V, Eyers CE
Science signaling 2021 Jul 20;14(692)
Science signaling 2021 Jul 20;14(692)
Mitochondrial creatine kinase 1 in non-small cell lung cancer progression and hypoxia adaptation.
Li M, Liu H, Li J, Guo S, Lv Y
Respiratory research 2021 Jul 1;22(1):190
Respiratory research 2021 Jul 1;22(1):190
MSH6 Aggravates the Hypoxic Microenvironment via Regulating HIF1A to Promote the Metastasis of Glioblastoma Multiforme.
Shi Y, Jiang J, Cui Y, Chen Y, Dong T, An H, Liu P
DNA and cell biology 2021 Jan;40(1):93-100
DNA and cell biology 2021 Jan;40(1):93-100
Transcription factor YY1 enhances the stemness of lung cancer cells by stabilizing hypoxia factor HIF-1α under a hypoxic microenvironment.
Huang X, Zhou W, Zhang Y
Environmental toxicology 2021 Jan;36(1):114-122
Environmental toxicology 2021 Jan;36(1):114-122
Reprogramming of m(6)A epitranscriptome is crucial for shaping of transcriptome and proteome in response to hypoxia.
Wang YJ, Yang B, Lai Q, Shi JF, Peng JY, Zhang Y, Hu KS, Li YQ, Peng JW, Yang ZZ, Li YT, Pan Y, Koeffler HP, Liao JY, Yin D
RNA biology 2021 Jan;18(1):131-143
RNA biology 2021 Jan;18(1):131-143
Hypoxia-induced FOXO4/LDHA axis modulates gastric cancer cell glycolysis and progression.
Wang XH, Jiang ZH, Yang HM, Zhang Y, Xu LH
Clinical and translational medicine 2021 Jan;11(1):e279
Clinical and translational medicine 2021 Jan;11(1):e279
Identification of the atypical cadherin FAT1 as a novel glypican-3 interacting protein in liver cancer cells.
Meng P, Zhang YF, Zhang W, Chen X, Xu T, Hu S, Liang X, Feng M, Yang X, Ho M
Scientific reports 2021 Jan 8;11(1):40
Scientific reports 2021 Jan 8;11(1):40
Enhanced renoprotective effect of GDNF-modified adipose-derived mesenchymal stem cells on renal interstitial fibrosis.
Li S, Wang Y, Wang Z, Chen L, Zuo B, Liu C, Sun D
Stem cell research & therapy 2021 Jan 7;12(1):27
Stem cell research & therapy 2021 Jan 7;12(1):27
SIRT6 promotes angiogenesis and hemorrhage of carotid plaque via regulating HIF-1α and reactive oxygen species.
Yang Z, Huang Y, Zhu L, Yang K, Liang K, Tan J, Yu B
Cell death & disease 2021 Jan 12;12(1):77
Cell death & disease 2021 Jan 12;12(1):77
Canstatin represses glioma growth by inhibiting formation of VM-like structures.
Ma Y, Wu T, Zhou H, He G, Li Y, Wang B, Guo Q, Chen B, Li W
Translational neuroscience 2021 Jan 1;12(1):309-319
Translational neuroscience 2021 Jan 1;12(1):309-319
Long noncoding RNA SNHG6 promotes carcinogenesis by enhancing YBX1-mediated translation of HIF1α in clear cell renal cell carcinoma.
Zhao P, Deng Y, Wu Y, Guo Q, Zhou L, Yang X, Wang C
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21160
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Feb;35(2):e21160
BML-111, the lipoxin A(4) agonist, modulates VEGF or CoCl(2)-induced migration, angiogenesis and permeability in tumor-derived endothelial cells.
Lin L, Wang Q, Xu F, Luo X, Xu J, Yan L, Li Q, Hao H
Immunology letters 2021 Feb;230:27-35
Immunology letters 2021 Feb;230:27-35
Jiedu Sangen decoction inhibits chemoresistance to 5-fluorouracil of colorectal cancer cells by suppressing glycolysis via PI3K/AKT/HIF-1α signaling pathway.
Sun LT, Zhang LY, Shan FY, Shen MH, Ruan SM
Chinese journal of natural medicines 2021 Feb;19(2):143-152
Chinese journal of natural medicines 2021 Feb;19(2):143-152
IL-8 exacerbates alcohol-induced fatty liver disease via the Akt/HIF-1α pathway in human IL-8-expressing mice.
Wang Z, Li B, Jiang H, Ma Y, Bao Y, Zhu X, Xia H, Jin Y
Cytokine 2021 Feb;138:155402
Cytokine 2021 Feb;138:155402
Aldehyde Dehydrogenase, a Therapeutic Target in Chordoma: Analysis in 3D Cellular Models.
Locquet MA, Dechaume AL, Berchard P, Abbes L, Pissaloux D, Tirode F, Ramos I, Bedoucha J, Valantin J, Karanian M, Perret R, Gille O, Blay JY, Dutour A
Cells 2021 Feb 15;10(2)
Cells 2021 Feb 15;10(2)
microRNA-322/424 promotes liver fibrosis by regulating angiogenesis through targeting CUL2/HIF-1α pathway.
Wang Q, Zhang F, Lei Y, Liu P, Liu C, Tao Y
Life sciences 2021 Feb 1;266:118819
Life sciences 2021 Feb 1;266:118819
HAX1 maintains the glioma progression in hypoxia through promoting mitochondrial fission.
Lin J, Wang Y, Lin Z
Journal of cellular and molecular medicine 2021 Dec;25(24):11170-11184
Journal of cellular and molecular medicine 2021 Dec;25(24):11170-11184
A single-cell transcriptomic landscape of the lungs of patients with COVID-19.
Wang S, Yao X, Ma S, Ping Y, Fan Y, Sun S, He Z, Shi Y, Sun L, Xiao S, Song M, Cai J, Li J, Tang R, Zhao L, Wang C, Wang Q, Zhao L, Hu H, Liu X, Sun G, Chen L, Pan G, Chen H, Li Q, Zhang P, Xu Y, Feng H, Zhao GG, Wen T, Yang Y, Huang X, Li W, Liu Z, Wang H, Wu H, Hu B, Ren Y, Zhou Q, Qu J, Zhang W, Liu GH, Bian XW
Nature cell biology 2021 Dec;23(12):1314-1328
Nature cell biology 2021 Dec;23(12):1314-1328
Hypoxia-inducible factor-1alpha protects the liver against ischemia-reperfusion injury by regulating the A2B adenosine receptor.
Zhang X, Du P, Luo K, Li Y, Liu Z, Wang W, Zeng C, Ye Q, Xiao Q
Bioengineered 2021 Dec;12(1):3737-3752
Bioengineered 2021 Dec;12(1):3737-3752
miR-126 regulates angiogenesis in myocardial ischemia by targeting HIF-1α.
Gao S, Gao H, Dai L, Han Y, Lei Z, Wang X, Chang H, Liu S, Wang Z, Tong H, Wu H
Experimental cell research 2021 Dec 15;409(2):112925
Experimental cell research 2021 Dec 15;409(2):112925
Inhibitory effect of maspinon neovascularization in diabetic retinopathy.
Qiu F, Tong HJ
World journal of diabetes 2021 Dec 15;12(12):2050-2057
World journal of diabetes 2021 Dec 15;12(12):2050-2057
Guanosine and uridine alleviate airway inflammation via inhibition of the MAPK and NF-κB signals in OVA-induced asthmatic mice.
Luo Y, Chen H, Huang R, Wu Q, Li Y, He Y
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Pulmonary pharmacology & therapeutics 2021 Aug;69:102049
Lysosome Fe(2+) release is responsible for etoposide- and cisplatin-induced stemness of small cell lung cancer cells.
Wang K, Chen X, Zuyi W, Chen L, Fu W
Environmental toxicology 2021 Aug;36(8):1654-1663
Environmental toxicology 2021 Aug;36(8):1654-1663
Leptin attenuates hypoxia-induced apoptosis in human periodontal ligament cells via the reactive oxygen species-hypoxia-inducible factor-1α pathway.
Gao J, Zhu J, Zhao Y, Gan X, Yu H
Experimental physiology 2021 Aug;106(8):1752-1761
Experimental physiology 2021 Aug;106(8):1752-1761
USP14 maintains HIF1-α stabilization via its deubiquitination activity in hepatocellular carcinoma.
Lv C, Wang S, Lin L, Wang C, Zeng K, Meng Y, Sun G, Wei S, Liu Y, Zhao Y
Cell death & disease 2021 Aug 21;12(9):803
Cell death & disease 2021 Aug 21;12(9):803
STAT3/LINC00671 axis regulates papillary thyroid tumor growth and metastasis via LDHA-mediated glycolysis.
Huo N, Cong R, Sun ZJ, Li WC, Zhu X, Xue CY, Chen Z, Ma LY, Chu Z, Han YC, Kang XF, Jia SH, Du N, Kang L, Xu XJ
Cell death & disease 2021 Aug 17;12(9):799
Cell death & disease 2021 Aug 17;12(9):799
Hepatic metastasis of gastric cancer is associated with enhanced expression of ethanolamine kinase 2 via the p53-Bcl-2 intrinsic apoptosis pathway.
Miwa T, Kanda M, Shimizu D, Umeda S, Sawaki K, Tanaka H, Tanaka C, Hattori N, Hayashi M, Yamada S, Nakayama G, Koike M, Kodera Y
British journal of cancer 2021 Apr;124(8):1449-1460
British journal of cancer 2021 Apr;124(8):1449-1460
Withanolides from dietary tomatillo suppress HT1080 cancer cell growth by targeting mutant IDH1.
Yang Y, Xiang K, Sun D, Zheng M, Song Z, Li M, Wang X, Li H, Chen L
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
Bioorganic & medicinal chemistry 2021 Apr 15;36:116095
NDUFA4L2 Regulated by HIF-1α Promotes Metastasis and Epithelial-Mesenchymal Transition of Osteosarcoma Cells Through Inhibiting ROS Production.
Xu WN, Yang RZ, Zheng HL, Jiang LS, Jiang SD
Frontiers in cell and developmental biology 2020;8:515051
Frontiers in cell and developmental biology 2020;8:515051
MicroRNA-143-5p modulates pulmonary artery smooth muscle cells functions in hypoxic pulmonary hypertension through targeting HIF-1α.
Tang BI, Tang MM, Xu QM, Guo JL, Xuan L, Zhou J, Wang XJ, Zhang H, Kang PF
Journal of biosciences 2020;45
Journal of biosciences 2020;45
Citron Rho-Interacting Serine/Threonine Kinase Promotes HIF1a-CypA Signaling and Growth of Human Pancreatic Adenocarcinoma.
Cong L, Bai Z, Du Y, Cheng Y
BioMed research international 2020;2020:9210891
BioMed research international 2020;2020:9210891
Gallbladder Cancer Progression Is Reversed by Nanomaterial-Induced Photothermal Therapy in Combination with Chemotherapy and Autophagy Inhibition.
Cai Q, Wang X, Wang S, Jin L, Ding J, Zhou D, Ma F
International journal of nanomedicine 2020;15:253-262
International journal of nanomedicine 2020;15:253-262
Empagliflozin Protects Against Proximal Renal Tubular Cell Injury Induced by High Glucose via Regulation of Hypoxia-Inducible Factor 1-Alpha.
Ndibalema AR, Kabuye D, Wen S, Li L, Li X, Fan Q
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
Diabetes, metabolic syndrome and obesity : targets and therapy 2020;13:1953-1967
DUSP9 Suppresses Proliferation and Migration of Clear Cell Renal Cell Carcinoma via the mTOR Pathway.
Luo J, Luo X, Liu X, Fang Z, Xu J, Li L
OncoTargets and therapy 2020;13:1321-1330
OncoTargets and therapy 2020;13:1321-1330
The Regulatory Mechanism and Biological Significance of Mitochondrial Calcium Uniporter in the Migration, Invasion, Angiogenesis and Growth of Gastric Cancer.
Wang X, Song X, Cheng G, Zhang J, Dong L, Bai J, Luo D, Xiong Y, Li S, Liu F, Sun Y, Wang X, Li Y, Huang Y
OncoTargets and therapy 2020;13:11781-11794
OncoTargets and therapy 2020;13:11781-11794
Role of GLUT-1 in the Upregulation of PD-L1 Expression After Radiotherapy and Association of PD-L1 with Favourable Overall Survival in Hypopharyngeal Cancer.
Shen LF, Zhou SH, Guo Y
OncoTargets and therapy 2020;13:11221-11235
OncoTargets and therapy 2020;13:11221-11235
MiR-935/HIF1α Feedback Loop Inhibits the Proliferation and Invasiveness of Glioma.
Huang G, Chen J, Liu J, Zhang X, Duan H, Fang Q
OncoTargets and therapy 2020;13:10817-10828
OncoTargets and therapy 2020;13:10817-10828
Distinct Roles of VEGFA and ANGPT2 in Lung Adenocarcinoma and Squamous Cell Carcinoma.
Qin S, Yi M, Jiao D, Li A, Wu K
Journal of Cancer 2020;11(1):153-167
Journal of Cancer 2020;11(1):153-167
Human Umbilical Cord Mesenchymal Stem Cell Differentiation Into Odontoblast-Like Cells and Endothelial Cells: A Potential Cell Source for Dental Pulp Tissue Engineering.
Zhang S, Zhang W, Li Y, Ren L, Deng H, Yin X, Gao X, Pan S, Niu Y
Frontiers in physiology 2020;11:593
Frontiers in physiology 2020;11:593
Integrated Analysis of Key Genes and Pathways Involved in Fetal Growth Restriction and Their Associations With the Dysregulation of the Maternal Immune System.
Wang X, Zhu H, Lei L, Zhang Y, Tang C, Wu JX, Zhou JR, Xiao XR
Frontiers in genetics 2020;11:581789
Frontiers in genetics 2020;11:581789
Characterization of Group I Metabotropic Glutamate Receptors in Rat and Human Adrenal Glands.
Fan YN, Li C, Huang L, Chen L, Tang Z, Han G, Liu Y
Frontiers in physiology 2020;11:401
Frontiers in physiology 2020;11:401
Critical Role of AdipoR1 in Regulating Th17 Cell Differentiation Through Modulation of HIF-1α-Dependent Glycolysis.
Zhang Q, Wang L, Jiang J, Lin S, Luo A, Zhao P, Tan W, Zhang M
Frontiers in immunology 2020;11:2040
Frontiers in immunology 2020;11:2040
Hypoxia-induced lncRNA-AC020978 promotes proliferation and glycolytic metabolism of non-small cell lung cancer by regulating PKM2/HIF-1α axis.
Hua Q, Mi B, Xu F, Wen J, Zhao L, Liu J, Huang G
Theranostics 2020;10(11):4762-4778
Theranostics 2020;10(11):4762-4778
Dual inhibition of VEGF and PARP suppresses KRAS-mutant colorectal cancer.
Zhong L, Wang R, Wang Y, Peng S, Ma Y, Ding S, Yang H, Chen S, Luo X, Wang W
Neoplasia (New York, N.Y.) 2020 Sep;22(9):365-375
Neoplasia (New York, N.Y.) 2020 Sep;22(9):365-375
Antitumor effects of aconitine in A2780 cells via estrogen receptor β‑mediated apoptosis, DNA damage and migration.
Wang X, Lin Y, Zheng Y
Molecular medicine reports 2020 Sep;22(3):2318-2328
Molecular medicine reports 2020 Sep;22(3):2318-2328
Hypoxia regulates the degradation of non-nuclear organelles during lens differentiation through activation of HIF1a.
Brennan L, Disatham J, Kantorow M
Experimental eye research 2020 Sep;198:108129
Experimental eye research 2020 Sep;198:108129
Therapeutic effects of Choreito, a traditional Japanese (Kampo) medicine, on detrusor overactivity induced by acetic acid in rats.
Ueno M, Minagawa T, Saito T, Imamura T, Nagai T, Ogawa T, Ishizuka O
Lower urinary tract symptoms 2020 Sep;12(3):198-205
Lower urinary tract symptoms 2020 Sep;12(3):198-205
The AKT/GSK3-Mediated Slug Expression Contributes to Oxaliplatin Resistance in Colorectal Cancer via Upregulation of ERCC1.
Wei W, Ma XD, Jiang GM, Shi B, Zhong W, Sun CL, Zhao L, Hou YJ, Wang H
Oncology research 2020 Sep 1;28(4):423-438
Oncology research 2020 Sep 1;28(4):423-438
Homocysteine promotes hepatic steatosis by activating the adipocyte lipolysis in a HIF1α-ERO1α-dependent oxidative stress manner.
Yan Y, Wu X, Wang P, Zhang S, Sun L, Zhao Y, Zeng G, Liu B, Xu G, Liu H, Wang L, Wang X, Jiang C
Redox biology 2020 Oct;37:101742
Redox biology 2020 Oct;37:101742
Hypoxia-autophagy axis induces VEGFA by peritoneal mesothelial cells to promote gastric cancer peritoneal metastasis through an integrin α5-fibronectin pathway.
Wang X, Che X, Yu Y, Cheng Y, Bai M, Yang Z, Guo Q, Xie X, Li D, Guo M, Hou K, Guo W, Qu X, Cao L
Journal of experimental & clinical cancer research : CR 2020 Oct 20;39(1):221
Journal of experimental & clinical cancer research : CR 2020 Oct 20;39(1):221
USP22 positively modulates ERα action via its deubiquitinase activity in breast cancer.
Wang S, Zhong X, Wang C, Luo H, Lin L, Sun H, Sun G, Zeng K, Zou R, Liu W, Sun N, Song H, Liu W, Zhang Q, Liao Z, Teng X, Zhou T, Sun X, Zhao Y
Cell death and differentiation 2020 Nov;27(11):3131-3145
Cell death and differentiation 2020 Nov;27(11):3131-3145
Anti-tumor efficacy of CKD-516 in combination with radiation in xenograft mouse model of lung squamous cell carcinoma.
Kim MY, Shin JY, Kim JO, Son KH, Kim YS, Jung CK, Kang JH
BMC cancer 2020 Nov 3;20(1):1057
BMC cancer 2020 Nov 3;20(1):1057
Effect of conditioned medium from neural stem cells on glioma progression and its protein expression profile analysis.
Zhang GL, Qian C, Zhang SZ, Tuo YH, Zeng BY, Ji YX, Wang YZ
World journal of stem cells 2020 Nov 26;12(11):1396-1409
World journal of stem cells 2020 Nov 26;12(11):1396-1409
MiR-103a-3p promotes tumour glycolysis in colorectal cancer via hippo/YAP1/HIF1A axis.
Sun Z, Zhang Q, Yuan W, Li X, Chen C, Guo Y, Shao B, Dang Q, Zhou Q, Wang Q, Wang G, Liu J, Kan Q
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
Journal of experimental & clinical cancer research : CR 2020 Nov 20;39(1):250
LncRNA HOTAIR knockdown inhibits glycolysis by regulating miR-130a-3p/HIF1A in hepatocellular carcinoma under hypoxia.
Hu M, Fu Q, Jing C, Zhang X, Qin T, Pan Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109703
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 May;125:109703
Hirudin Reduces the Expression of Markers of the Extracellular Matrix in Renal Tubular Epithelial Cells in a Rat Model of Diabetic Kidney Disease Through the Hypoxia-Inducible Factor-1α (HIF-1α)/Vascular Endothelial Growth Factor (VEGF) Signaling Pathway.
Pang X, Zhang Y, Shi X, Peng Z, Xing Y, Jiarui H
Medical science monitor : international medical journal of experimental and clinical research 2020 May 30;26:e921894
Medical science monitor : international medical journal of experimental and clinical research 2020 May 30;26:e921894
P-21-activated kinase 1 contributes to tumor angiogenesis upon photodynamic therapy via the HIF-1α/VEGF pathway.
Jiang S, Gao Y, Yu QH, Li M, Cheng X, Hu SB, Song ZF, Zheng QC
Biochemical and biophysical research communications 2020 May 21;526(1):98-104
Biochemical and biophysical research communications 2020 May 21;526(1):98-104
Micheliolide Enhances Radiosensitivities of p53-Deficient Non-Small-Cell Lung Cancer via Promoting HIF-1α Degradation.
Kong P, Yu KN, Yang M, Almahi WA, Nie L, Chen G, Han W
International journal of molecular sciences 2020 May 11;21(9)
International journal of molecular sciences 2020 May 11;21(9)
Synthesis and biological evaluation of novel 5,6,7-trimethoxy flavonoid salicylate derivatives as potential anti-tumor agents.
Liu R, Deng X, Peng Y, Feng W, Xiong R, Zou Y, Lei X, Zheng X, Xie Z, Tang G
Bioorganic chemistry 2020 Mar;96:103652
Bioorganic chemistry 2020 Mar;96:103652
MTFP1 overexpression promotes the growth of oral squamous cell carcinoma by inducing ROS production.
Xiao T, Sun J, Xing Z, Xie F, Yang L, Ding W
Cell biology international 2020 Mar;44(3):821-829
Cell biology international 2020 Mar;44(3):821-829
The effect of high glucose on the biological characteristics of nucleus pulposus-derived mesenchymal stem cells.
Liu Y, Li Y, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Cell biochemistry and function 2020 Mar;38(2):130-140
Cell biochemistry and function 2020 Mar;38(2):130-140
Inhibiting both proline biosynthesis and lipogenesis synergistically suppresses tumor growth.
Liu M, Wang Y, Yang C, Ruan Y, Bai C, Chu Q, Cui Y, Chen C, Ying G, Li B
The Journal of experimental medicine 2020 Mar 2;217(3)
The Journal of experimental medicine 2020 Mar 2;217(3)
Cytotoxic necrotizing factor 1 promotes bladder cancer angiogenesis through activating RhoC.
Guo Y, Wang J, Zhou K, Lv J, Wang L, Gao S, Keller ET, Zhang ZS, Wang Q, Yao Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7927-7940
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jun;34(6):7927-7940
Hypoxia-preconditioned olfactory mucosa mesenchymal stem cells abolish cerebral ischemia/reperfusion-induced pyroptosis and apoptotic death of microglial cells by activating HIF-1α.
Huang Y, Tan F, Zhuo Y, Liu J, He J, Duan D, Lu M, Hu Z
Aging 2020 Jun 7;12(11):10931-10950
Aging 2020 Jun 7;12(11):10931-10950
Role of Central Hypo-enhancement in the Hepatic Arterial Phase of Dynamic Computed Tomography in Patients with Mass-Forming Intrahepatic Cholangiocarcinoma.
Teraoku H, Morine Y, Uyama N, Ikemoto T, Iwahashi S, Saito Y, Takasu C, Imura S, Harada M, Shimada M
World journal of surgery 2020 Jul;44(7):2350-2358
World journal of surgery 2020 Jul;44(7):2350-2358
Knockdown of KRT17 decreases osteosarcoma cell proliferation and the Warburg effect via the AKT/mTOR/HIF1α pathway.
Yan X, Yang C, Hu W, Chen T, Wang Q, Pan F, Qiu B, Tang B
Oncology reports 2020 Jul;44(1):103-114
Oncology reports 2020 Jul;44(1):103-114
HIF1α/PLD2 axis linked to glycolysis induces T-cell immunity in oral lichen planus.
Wang F, Zhang J, Zhou G
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Biochimica et biophysica acta. General subjects 2020 Jul;1864(7):129602
Severe OSA associated with higher risk of mortality in stage III and IV lung cancer.
Huang HY, Lin SW, Chuang LP, Wang CL, Sun MH, Li HY, Chang CJ, Chang SC, Yang CT, Chen NH
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2020 Jul 15;16(7):1091-1098
Journal of clinical sleep medicine : JCSM : official publication of the American Academy of Sleep Medicine 2020 Jul 15;16(7):1091-1098
Hypoxic mast cells accelerate the proliferation, collagen accumulation and phenotypic alteration of human lung fibroblasts.
Wang X, Lin L, Chai X, Wu Y, Li Y, Liu X
International journal of molecular medicine 2020 Jan;45(1):175-185
International journal of molecular medicine 2020 Jan;45(1):175-185
SLC6A8 Knockdown Suppresses the Invasion and Migration of Human Hepatocellular Carcinoma Huh-7 and Hep3B Cells.
Yuan L, Wu XJ, Li WC, Zhuo C, Xu Z, Tan C, Ma R, Wang J, Pu J
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820983029
Technology in cancer research & treatment 2020 Jan-Dec;19:1533033820983029
Simvastatin re-sensitizes hepatocellular carcinoma cells to sorafenib by inhibiting HIF-1α/PPAR-γ/PKM2-mediated glycolysis.
Feng J, Dai W, Mao Y, Wu L, Li J, Chen K, Yu Q, Kong R, Li S, Zhang J, Ji J, Wu J, Mo W, Xu X, Guo C
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
Journal of experimental & clinical cancer research : CR 2020 Jan 30;39(1):24
MCP-1/CCR-2 axis in adipocytes and cancer cell respectively facilitates ovarian cancer peritoneal metastasis.
Sun C, Li X, Guo E, Li N, Zhou B, Lu H, Huang J, Xia M, Shan W, Wang B, Li K, Weng D, Xu X, Gao Q, Wang S, Hu J, Lu Y, Mills GB, Chen G
Oncogene 2020 Feb;39(8):1681-1695
Oncogene 2020 Feb;39(8):1681-1695
CHCHD2 is a potential prognostic factor for NSCLC and is associated with HIF-1a expression.
Yin X, Xia J, Sun Y, Zhang Z
BMC pulmonary medicine 2020 Feb 13;20(1):40
BMC pulmonary medicine 2020 Feb 13;20(1):40
Dihydroartemisinin inhibits endothelial cell tube formation by suppression of the STAT3 signaling pathway.
Gao P, Wang LL, Liu J, Dong F, Song W, Liao L, Wang B, Zhang W, Zhou X, Xie Q, Sun R, Liu J
Life sciences 2020 Feb 1;242:117221
Life sciences 2020 Feb 1;242:117221
LncRNA NUTM2A-AS1 positively modulates TET1 and HIF-1A to enhance gastric cancer tumorigenesis and drug resistance by sponging miR-376a.
Wang J, Yu Z, Wang J, Shen Y, Qiu J, Zhuang Z
Cancer medicine 2020 Dec;9(24):9499-9510
Cancer medicine 2020 Dec;9(24):9499-9510
Signatures of host-pathogen evolutionary conflict reveal MISTR-A conserved MItochondrial STress Response network.
Sorouri M, Chang T, Jesudhasan P, Pinkham C, Elde NC, Hancks DC
PLoS biology 2020 Dec;18(12):e3001045
PLoS biology 2020 Dec;18(12):e3001045
Enhanced fatty acid oxidation mediated by CPT1C promotes gastric cancer progression.
Chen T, Wu G, Hu H, Wu C
Journal of gastrointestinal oncology 2020 Aug;11(4):695-707
Journal of gastrointestinal oncology 2020 Aug;11(4):695-707
Caloric restriction alleviates aging-related fibrosis of kidney through downregulation of miR-21 in extracellular vesicles.
Liu JR, Cai GY, Ning YC, Wang JC, Lv Y, Guo YN, Fu B, Hong Q, Sun XF, Chen XM
Aging 2020 Aug 27;12(18):18052-18072
Aging 2020 Aug 27;12(18):18052-18072
Advanced glycation end products enhance macrophage polarization to the M1 phenotype via the HIF-1α/PDK4 pathway.
Han X, Ma W, Zhu Y, Sun X, Liu N
Molecular and cellular endocrinology 2020 Aug 20;514:110878
Molecular and cellular endocrinology 2020 Aug 20;514:110878
Bcl2 inhibitor ABT737 reverses the Warburg effect via the Sirt3-HIF1α axis to promote oxidative stress-induced apoptosis in ovarian cancer cells.
Dong D, Dong Y, Fu J, Lu S, Yuan C, Xia M, Sun L
Life sciences 2020 Aug 15;255:117846
Life sciences 2020 Aug 15;255:117846
Protective function of exosomes from adipose tissue-derived mesenchymal stem cells in acute kidney injury through SIRT1 pathway.
Gao F, Zuo B, Wang Y, Li S, Yang J, Sun D
Life sciences 2020 Aug 15;255:117719
Life sciences 2020 Aug 15;255:117719
Suppression of CLEC3A inhibits osteosarcoma cell proliferation and promotes their chemosensitivity through the AKT1/mTOR/HIF1α signaling pathway.
Ren C, Pan R, Hou L, Wu H, Sun J, Zhang W, Tian X, Chen H
Molecular medicine reports 2020 Apr;21(4):1739-1748
Molecular medicine reports 2020 Apr;21(4):1739-1748
Systemic hypoxia potentiates anti-tumor effects of metformin in hepatocellular carcinoma in mice.
Lin H, Zhou W, Huang Y, Ren M, Xu F, Wang H
Acta biochimica et biophysica Sinica 2020 Apr 20;52(4):421-429
Acta biochimica et biophysica Sinica 2020 Apr 20;52(4):421-429
Circadian clock gene Clock is involved in the pathogenesis of preeclampsia through hypoxia.
Li Y, Li J, Hou Y, Huang L, Bian Y, Song G, Qiao C
Life sciences 2020 Apr 15;247:117441
Life sciences 2020 Apr 15;247:117441
Acidic Microenvironment Up-Regulates Exosomal miR-21 and miR-10b in Early-Stage Hepatocellular Carcinoma to Promote Cancer Cell Proliferation and Metastasis.
Tian XP, Wang CY, Jin XH, Li M, Wang FW, Huang WJ, Yun JP, Xu RH, Cai QQ, Xie D
Theranostics 2019;9(7):1965-1979
Theranostics 2019;9(7):1965-1979
Oncogenic MSH6-CXCR4-TGFB1 Feedback Loop: A Novel Therapeutic Target of Photothermal Therapy in Glioblastoma Multiforme.
Chen Y, Liu P, Sun P, Jiang J, Zhu Y, Dong T, Cui Y, Tian Y, An T, Zhang J, Li Z, Yang X
Theranostics 2019;9(5):1453-1473
Theranostics 2019;9(5):1453-1473
Reversing activity of cancer associated fibroblast for staged glycolipid micelles against internal breast tumor cells.
Zhu Y, Yu F, Tan Y, Hong Y, Meng T, Liu Y, Dai S, Qiu G, Yuan H, Hu F
Theranostics 2019;9(23):6764-6779
Theranostics 2019;9(23):6764-6779
Hypoxia-induced H19/YB-1 cascade modulates cardiac remodeling after infarction.
Choong OK, Chen CY, Zhang J, Lin JH, Lin PJ, Ruan SC, Kamp TJ, Hsieh PCH
Theranostics 2019;9(22):6550-6567
Theranostics 2019;9(22):6550-6567
LncRNA-MTA2TR functions as a promoter in pancreatic cancer via driving deacetylation-dependent accumulation of HIF-1α.
Zeng Z, Xu FY, Zheng H, Cheng P, Chen QY, Ye Z, Zhong JX, Deng SJ, Liu ML, Huang K, Li Q, Li W, Hu YH, Wang F, Wang CY, Zhao G
Theranostics 2019;9(18):5298-5314
Theranostics 2019;9(18):5298-5314
Hypoxia-induced feedback of HIF-1α and lncRNA-CF129 contributes to pancreatic cancer progression through stabilization of p53 protein.
Liu M, Zhong J, Zeng Z, Huang K, Ye Z, Deng S, Chen H, Xu F, Li Q, Zhao G
Theranostics 2019;9(16):4795-4810
Theranostics 2019;9(16):4795-4810
Targeting JUN, CEBPB, and HDAC3: A Novel Strategy to Overcome Drug Resistance in Hypoxic Glioblastoma.
Gao Y, Liu B, Feng L, Sun B, He S, Yang Y, Wu G, E G, Liu C, Gao Y, Zhang E, Zhu B
Frontiers in oncology 2019;9:33
Frontiers in oncology 2019;9:33
RAD51 is a potential marker for prognosis and regulates cell proliferation in pancreatic cancer.
Zhang X, Ma N, Yao W, Li S, Ren Z
Cancer cell international 2019;19:356
Cancer cell international 2019;19:356
Aspirin, a Potential GLUT1 Inhibitor in a Vascular Endothelial Cell Line.
Hu Y, Lou X, Wang R, Sun C, Liu X, Liu S, Wang Z, Ni C
Open medicine (Warsaw, Poland) 2019;14:552-560
Open medicine (Warsaw, Poland) 2019;14:552-560
Proinflammatory-factors-carrying-microvesicles from monocytes induced by high glucose enhance the activation of HIF/VEGF pathway in human renal mesangial cells.
Li M, Yu J, Sun L
International journal of clinical and experimental pathology 2019;12(8):2967-2971
International journal of clinical and experimental pathology 2019;12(8):2967-2971
Hypoxic non-small-cell lung cancer cell-derived exosomal miR-21 promotes resistance of normoxic cell to cisplatin.
Dong C, Liu X, Wang H, Li J, Dai L, Li J, Xu Z
OncoTargets and therapy 2019;12:1947-1956
OncoTargets and therapy 2019;12:1947-1956
HIF1α/miR-520a-3p/AKT1/mTOR Feedback Promotes The Proliferation And Glycolysis Of Gastric Cancer Cells.
Pan C, Liu Q, Wu X
Cancer management and research 2019;11:10145-10156
Cancer management and research 2019;11:10145-10156
HIF-1α Regulates Glucocorticoid-Induced Osteoporosis Through PDK1/AKT/mTOR Signaling Pathway.
Xu WN, Zheng HL, Yang RZ, Jiang LS, Jiang SD
Frontiers in endocrinology 2019;10:922
Frontiers in endocrinology 2019;10:922
Sedum sarmentosum Bunge extract alleviates inflammation and kidney injury via inhibition of M1-macrophage polarization.
Lu H, Cheng S, Wu C, Zheng S, Hong W, Liu L, Bai Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 Sep;62:152976
Phytomedicine : international journal of phytotherapy and phytopharmacology 2019 Sep;62:152976
Association between CIRP expression and hypoxic-ischemic brain injury in neonatal rats.
Chen L, Tian Q, Wang W
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Experimental and therapeutic medicine 2019 Sep;18(3):1515-1520
Prolyl hydroxylase 3 involvement in lung cancer progression under hypoxic conditions: association with hypoxia-inducible factor-1α and pyruvate kinase M2.
Chu X, Xiang M, Feng L, Liu H, Zhou C
Journal of thoracic disease 2019 Sep;11(9):3941-3950
Journal of thoracic disease 2019 Sep;11(9):3941-3950
Rubidium-Containing Calcium Alginate Hydrogel for Antibacterial and Diabetic Skin Wound Healing Applications.
He X, Ding Y, Xie W, Sun R, Hunt NC, Song J, Sun X, Peng C, Zeng Q, Tan Y, Liu Y
ACS biomaterials science & engineering 2019 Sep 9;5(9):4726-4738
ACS biomaterials science & engineering 2019 Sep 9;5(9):4726-4738
Oleanolic acid reduces aerobic glycolysis-associated proliferation by inhibiting yes-associated protein in gastric cancer cells.
Li Y, Xu Q, Yang W, Wu T, Lu X
Gene 2019 Sep 5;712:143956
Gene 2019 Sep 5;712:143956
Downregulation of exosomal CLEC3B in hepatocellular carcinoma promotes metastasis and angiogenesis via AMPK and VEGF signals.
Dai W, Wang Y, Yang T, Wang J, Wu W, Gu J
Cell communication and signaling : CCS 2019 Sep 2;17(1):113
Cell communication and signaling : CCS 2019 Sep 2;17(1):113
Asparaginyl endopeptidase induces endothelial permeability and tumor metastasis via downregulating zonula occludens protein ZO-1.
Kang L, Shen L, Lu L, Wang D, Zhao Y, Chen C, Du L, Gong J, Zhang Y, Mi X, Xiang R, Zhang M, Tan X
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2267-2275
Biochimica et biophysica acta. Molecular basis of disease 2019 Sep 1;1865(9):2267-2275
Relationship between Intracellular Signaling of the (Pro)renin Receptor and the Pathogenesis of Preeclampsia.
Tamada S, Mitsui T, Ohira A, Tani K, Maki J, Eguchi T, Eto E, Hayata K, Masuyama H
Acta medica Okayama 2019 Oct;73(5):433-440
Acta medica Okayama 2019 Oct;73(5):433-440
DZNep inhibits Hif-1α and Wnt signalling molecules to attenuate the proliferation and invasion of BGC-823 gastric cancer cells.
Huang R, Jin X, Gao Y, Yuan H, Wang F, Cao X
Oncology letters 2019 Oct;18(4):4308-4316
Oncology letters 2019 Oct;18(4):4308-4316
Discovery of Novel Aryl Carboxamide Derivatives as Hypoxia-Inducible Factor 1α Signaling Inhibitors with Potent Activities of Anticancer Metastasis.
Liu M, Liang Y, Zhu Z, Wang J, Cheng X, Cheng J, Xu B, Li R, Liu X, Wang Y
Journal of medicinal chemistry 2019 Oct 24;62(20):9299-9314
Journal of medicinal chemistry 2019 Oct 24;62(20):9299-9314
RUNX1 mutations promote leukemogenesis of myeloid malignancies in ASXL1-mutated leukemia.
Bera R, Chiu MC, Huang YJ, Lin TH, Kuo MC, Shih LY
Journal of hematology & oncology 2019 Oct 22;12(1):104
Journal of hematology & oncology 2019 Oct 22;12(1):104
Macrophage metabolic reprogramming aggravates aortic dissection through the HIF1α-ADAM17 pathway(✰).
Lian G, Li X, Zhang L, Zhang Y, Sun L, Zhang X, Liu H, Pang Y, Kong W, Zhang T, Wang X, Jiang C
EBioMedicine 2019 Nov;49:291-304
EBioMedicine 2019 Nov;49:291-304
Carbohydrate Antigen 19-9 Is a Prognostic Factor Which Correlates With HDAC1 and HIF-1α for Intrahepatic Cholangiocarcinoma.
Ohta S, Morine Y, Imura S, Ikemoto T, Arakawa Y, Iwahashi S, Saito YU, Yamada S, Wada Y, Yamashita S, Bando Y, Shimada M
Anticancer research 2019 Nov;39(11):6025-6033
Anticancer research 2019 Nov;39(11):6025-6033
Exogenous hydrogen sulfide protects against high glucose-induced apoptosis and oxidative stress by inhibiting the STAT3/HIF-1α pathway in H9c2 cardiomyocytes.
Li J, Yuan YQ, Zhang L, Zhang H, Zhang SW, Zhang Y, Xuan XX, Wang MJ, Zhang JY
Experimental and therapeutic medicine 2019 Nov;18(5):3948-3958
Experimental and therapeutic medicine 2019 Nov;18(5):3948-3958
Inhibiting Hypoxia and Chemotherapy-Induced Cancer Cell Metastasis under a Valid Therapeutic Effect by an Assistance of Biomimetic Oxygen Delivery.
Jiang MS, Yin XY, Qin B, Xuan SY, Yuan XL, Yin H, Zhu C, Li X, Yang J, Du YZ, Luo LH, You J
Molecular pharmaceutics 2019 Nov 4;16(11):4530-4541
Molecular pharmaceutics 2019 Nov 4;16(11):4530-4541
Mitochondrial NDUFA4L2 attenuates the apoptosis of nucleus pulposus cells induced by oxidative stress via the inhibition of mitophagy.
Xu WN, Zheng HL, Yang RZ, Liu T, Yu W, Zheng XF, Li B, Jiang SD, Jiang LS
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Experimental & molecular medicine 2019 Nov 18;51(11):1-16
Chronic fetal hypoxia disrupts the peri-conceptual environment in next-generation adult female rats.
Aiken CE, Tarry-Adkins JL, Spiroski AM, Nuzzo AM, Ashmore TJ, Rolfo A, Sutherland MJ, Camm EJ, Giussani DA, Ozanne SE
The Journal of physiology 2019 May;597(9):2391-2401
The Journal of physiology 2019 May;597(9):2391-2401
PKM2 is the target of proanthocyanidin B2 during the inhibition of hepatocellular carcinoma.
Feng J, Wu L, Ji J, Chen K, Yu Q, Zhang J, Chen J, Mao Y, Wang F, Dai W, Xu L, Wu J, Guo C
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Journal of experimental & clinical cancer research : CR 2019 May 17;38(1):204
Nuciferine inhibits the progression of glioblastoma by suppressing the SOX2-AKT/STAT3-Slug signaling pathway.
Li Z, Chen Y, An T, Liu P, Zhu J, Yang H, Zhang W, Dong T, Jiang J, Zhang Y, Jiang M, Yang X
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Journal of experimental & clinical cancer research : CR 2019 Mar 29;38(1):139
Beraprost sodium mitigates renal interstitial fibrosis through repairing renal microvessels.
Li S, Wang Y, Chen L, Wang Z, Liu G, Zuo B, Liu C, Sun D
Journal of molecular medicine (Berlin, Germany) 2019 Jun;97(6):777-791
Journal of molecular medicine (Berlin, Germany) 2019 Jun;97(6):777-791
Downregulation of microRNA‑199a‑5p attenuates hypoxia/reoxygenation‑induced cytotoxicity in cardiomyocytes by targeting the HIF‑1α‑GSK3β‑mPTP axis.
Liu DW, Zhang YN, Hu HJ, Zhang PQ, Cui W
Molecular medicine reports 2019 Jun;19(6):5335-5344
Molecular medicine reports 2019 Jun;19(6):5335-5344
UHRF1 promotes aerobic glycolysis and proliferation via suppression of SIRT4 in pancreatic cancer.
Hu Q, Qin Y, Ji S, Xu W, Liu W, Sun Q, Zhang Z, Liu M, Ni Q, Yu X, Xu X
Cancer letters 2019 Jun 28;452:226-236
Cancer letters 2019 Jun 28;452:226-236
The effect of intervertebral disc degenerative change on biological characteristics of nucleus pulposus mesenchymal stem cell: an in vitro study in rats.
Liu Y, Li Y, Huang ZN, Wang ZY, Nan LP, Wang F, Zhou SF, Wang JC, Feng XM, Zhang L
Connective tissue research 2019 Jul;60(4):376-388
Connective tissue research 2019 Jul;60(4):376-388
Co-Delivery of Metformin Enhances the Antimultidrug Resistant Tumor Effect of Doxorubicin by Improving Hypoxic Tumor Microenvironment.
Li Y, Luo J, Lin MT, Zhi P, Guo WW, Han M, You J, Gao JQ
Molecular pharmaceutics 2019 Jul 1;16(7):2966-2979
Molecular pharmaceutics 2019 Jul 1;16(7):2966-2979
Hypermethylated gene ANKDD1A is a candidate tumor suppressor that interacts with FIH1 and decreases HIF1α stability to inhibit cell autophagy in the glioblastoma multiforme hypoxia microenvironment.
Feng J, Zhang Y, She X, Sun Y, Fan L, Ren X, Fu H, Liu C, Li P, Zhao C, Liu Q, Liu Q, Li G, Wu M
Oncogene 2019 Jan;38(1):103-119
Oncogene 2019 Jan;38(1):103-119
Transplantation of Amniotic Fluid-Derived Stem Cells Preconditioned with Glial Cell Line-Derived Neurotrophic Factor Gene Alleviates Renal Fibrosis.
Li S, Zhao Y, Wang Z, Wang J, Liu C, Sun D
Cell transplantation 2019 Jan;28(1):65-78
Cell transplantation 2019 Jan;28(1):65-78
Coordinative metabolism of glutamine carbon and nitrogen in proliferating cancer cells under hypoxia.
Wang Y, Bai C, Ruan Y, Liu M, Chu Q, Qiu L, Yang C, Li B
Nature communications 2019 Jan 14;10(1):201
Nature communications 2019 Jan 14;10(1):201
Carpesium abrotanoides (L.) Root as a Potential Source of Natural Anticancer Compounds: Targeting Glucose Metabolism and PKM2/HIF-1α Axis of Breast Cancer Cells.
Chai XX, Le YF, Wang JC, Mei CX, Feng JF, Zhao H, Wang C, Lu DZ
Journal of food science 2019 Dec;84(12):3825-3832
Journal of food science 2019 Dec;84(12):3825-3832
HIF-1α/BNIP3 signaling pathway-induced-autophagy plays protective role during myocardial ischemia-reperfusion injury.
Zhang Y, Liu D, Hu H, Zhang P, Xie R, Cui W
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109464
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2019 Dec;120:109464
KDM3A Senses Oxygen Availability to Regulate PGC-1α-Mediated Mitochondrial Biogenesis.
Qian X, Li X, Shi Z, Bai X, Xia Y, Zheng Y, Xu D, Chen F, You Y, Fang J, Hu Z, Zhou Q, Lu Z
Molecular cell 2019 Dec 19;76(6):885-895.e7
Molecular cell 2019 Dec 19;76(6):885-895.e7
Extremely Effective Chemoradiotherapy by Inducing Immunogenic Cell Death and Radio-Triggered Drug Release under Hypoxia Alleviation.
Zhu C, Guo X, Luo L, Wu Z, Luo Z, Jiang M, Zhang J, Qin B, Shi Y, Lou Y, Qiu Y, You J
ACS applied materials & interfaces 2019 Dec 18;11(50):46536-46547
ACS applied materials & interfaces 2019 Dec 18;11(50):46536-46547
Nicotine-induced hypoxia in rat urothelium deteriorates bladder storage functions.
Nagai T, Imamura T, Ogawa T, Minagawa T, Domen T, Suzuki T, Ueno M, Ishizuka O
Neurourology and urodynamics 2019 Aug;38(6):1560-1570
Neurourology and urodynamics 2019 Aug;38(6):1560-1570
Bone marrow mesenchymal stem cells could reduce the toxic effects of hexavalent chromium on the liver by decreasing endoplasmic reticulum stress-mediated apoptosis via SIRT1/HIF-1α signaling pathway in rats.
Zhao Y, Yan J, Li AP, Zhang ZL, Li ZR, Guo KJ, Zhao KC, Ruan Q, Guo L
Toxicology letters 2019 Aug;310:31-38
Toxicology letters 2019 Aug;310:31-38
Epithelial-mesenchymal transition induced cancer-stem-cell-like characteristics in hepatocellular carcinoma.
Jing L, Ruan Z, Sun H, Li Q, Han L, Huang L, Yu S, Wang Y, Guo H, Jiao M
Journal of cellular physiology 2019 Aug;234(10):18448-18458
Journal of cellular physiology 2019 Aug;234(10):18448-18458
Cytotoxic Necrotizing Factor 1 Downregulates CD36 Transcription in Macrophages to Induce Inflammation During Acute Urinary Tract Infections.
Yang H, Li Q, Wang C, Wang J, Lv J, Wang L, Zhang ZS, Yao Z, Wang Q
Frontiers in immunology 2018;9:1987
Frontiers in immunology 2018;9:1987
Integrated Metabolomics and Network Pharmacology Approach to Explain Possible Action Mechanisms of Xin-Sheng-Hua Granule for Treating Anemia.
Pang HQ, Yue SJ, Tang YP, Chen YY, Tan YJ, Cao YJ, Shi XQ, Zhou GS, Kang A, Huang SL, Shi YJ, Sun J, Tang ZS, Duan JA
Frontiers in pharmacology 2018;9:165
Frontiers in pharmacology 2018;9:165
Ligand Activation of PPARγ by Ligustrazine Suppresses Pericyte Functions of Hepatic Stellate Cells via SMRT-Mediated Transrepression of HIF-1α.
Zhang F, Lu S, He J, Jin H, Wang F, Wu L, Shao J, Chen A, Zheng S
Theranostics 2018;8(3):610-626
Theranostics 2018;8(3):610-626
PGC-1α Participates in the Protective Effect of Chronic Intermittent Hypobaric Hypoxia on Cardiomyocytes.
Gu S, Hua H, Guo X, Jia Z, Zhang Y, Maslov LN, Zhang X, Ma H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;50(5):1891-1902
MicroRNA-224 Promotes Pancreatic Cancer Cell Proliferation and Migration by Targeting the TXNIP-Mediated HIF1α Pathway.
Zhu G, Zhou L, Liu H, Shan Y, Zhang X
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(4):1735-1746
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;48(4):1735-1746
FG-4592 Accelerates Cutaneous Wound Healing by Epidermal Stem Cell Activation via HIF-1α Stabilization.
Tang D, Zhang J, Yan T, Wei J, Jiang X, Zhang D, Zhang Q, Jia J, Huang Y
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2460-2470
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;46(6):2460-2470
MBD2 regulates differentiation and function of Th17 cells in neutrophils- dominant asthma via HIF-1α.
Xu L, Sun WJ, Jia AJ, Qiu LL, Xiao B, Mu L, Li JM, Zhang XF, Wei Y, Peng C, Zhang DS, Xiang XD
Journal of inflammation (London, England) 2018;15:15
Journal of inflammation (London, England) 2018;15:15
FBW7 suppresses metastasis of colorectal cancer by inhibiting HIF1α/CEACAM5 functional axis.
Li Q, Li Y, Li J, Ma Y, Dai W, Mo S, Xu Y, Li X, Cai S
International journal of biological sciences 2018;14(7):726-735
International journal of biological sciences 2018;14(7):726-735
Expression of glucose transporter-1, hypoxia inducible factor-1α and beclin-1 in head and neck cancer and their implication.
Lin W, Yin CY, Yu Q, Zhou SH, Chai L, Fan J, Wang WD
International journal of clinical and experimental pathology 2018;11(7):3708-3717
International journal of clinical and experimental pathology 2018;11(7):3708-3717
High HIF-1α expression predicts poor prognosis of patients with colon adenocarcinoma.
Huang ZY, Zhang LH, Zhao C, Liu R, Tong H, Gan C, Lan T, Tang CW, Gao JH
International journal of clinical and experimental pathology 2018;11(12):5635-5646
International journal of clinical and experimental pathology 2018;11(12):5635-5646
Gli1, a potential cancer stem cell marker, is strongly associated with prognosis in prostate cancer.
Lv L, Yang Z, Ma T, Xuan Y
International journal of clinical and experimental pathology 2018;11(10):4957-4966
International journal of clinical and experimental pathology 2018;11(10):4957-4966
Inhibition of GLUT-1 expression and the PI3K/Akt pathway to enhance the chemosensitivity of laryngeal carcinoma cells in vitro.
Jiang T, Zhou ML, Fan J
OncoTargets and therapy 2018;11:7865-7872
OncoTargets and therapy 2018;11:7865-7872
Cryptotanshinone suppresses cell proliferation and glucose metabolism via STAT3/SIRT3 signaling pathway in ovarian cancer cells.
Yang Y, Cao Y, Chen L, Liu F, Qi Z, Cheng X, Wang Z
Cancer medicine 2018 Sep;7(9):4610-4618
Cancer medicine 2018 Sep;7(9):4610-4618
Recombinant human maspin inhibits high glucose-induced oxidative stress and angiogenesis of human retinal microvascular endothelial cells via PI3K/AKT pathway.
Qiu F, Tong H, Wang Y, Tao J, Wang H, Chen L
Molecular and cellular biochemistry 2018 Sep;446(1-2):127-136
Molecular and cellular biochemistry 2018 Sep;446(1-2):127-136
SYT7 acts as a driver of hepatic metastasis formation of gastric cancer cells.
Kanda M, Tanaka H, Shimizu D, Miwa T, Umeda S, Tanaka C, Kobayashi D, Hattori N, Suenaga M, Hayashi M, Iwata N, Yamada S, Fujiwara M, Kodera Y
Oncogene 2018 Sep;37(39):5355-5366
Oncogene 2018 Sep;37(39):5355-5366
Anterior gradient 2 as a supervisory marker for tumor vessel normalization induced by anti-angiogenic treatment.
Pan F, Li W, Yang W, Yang XY, Liu S, Li X, Zhao X, Ding H, Qin L, Pan Y
Oncology letters 2018 Sep;16(3):3083-3091
Oncology letters 2018 Sep;16(3):3083-3091
Yes-associated protein (YAP) binds to HIF-1α and sustains HIF-1α protein stability to promote hepatocellular carcinoma cell glycolysis under hypoxic stress.
Zhang X, Li Y, Ma Y, Yang L, Wang T, Meng X, Zong Z, Sun X, Hua X, Li H
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Journal of experimental & clinical cancer research : CR 2018 Sep 4;37(1):216
Protective roles of NRF2 signaling pathway in cobalt chloride-induced hypoxic cytotoxicity in human HaCaT keratinocytes.
Yang B, Cheng H, Wang L, Fu J, Zhang G, Guan D, Qi R, Gao X, Zhao R
Toxicology and applied pharmacology 2018 Sep 15;355:189-197
Toxicology and applied pharmacology 2018 Sep 15;355:189-197
Long non‑coding RNA urothelial cancer associated 1 regulates radioresistance via the hexokinase 2/glycolytic pathway in cervical cancer.
Fan L, Huang C, Li J, Gao T, Lin Z, Yao T
International journal of molecular medicine 2018 Oct;42(4):2247-2259
International journal of molecular medicine 2018 Oct;42(4):2247-2259
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.
Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK
Aging cell 2018 Oct;17(5):e12800
Aging cell 2018 Oct;17(5):e12800
Dextran sulfate inhibition on human gastric cancer cells invasion, migration and epithelial-mesenchymal transformation.
Xu Y, Jin X, Huang Y, Wang J, Wang X, Wang H
Oncology letters 2018 Oct;16(4):5041-5049
Oncology letters 2018 Oct;16(4):5041-5049
Inhibition of lysyl oxidase expression by dextran sulfate affects invasion and migration of gastric cancer cells.
Xu Y, Wang X, Huang Y, Ma Y, Jin X, Wang H, Wang J
International journal of molecular medicine 2018 Nov;42(5):2737-2749
International journal of molecular medicine 2018 Nov;42(5):2737-2749
CRISPR/Cas9‑mediated hypoxia inducible factor‑1α knockout enhances the antitumor effect of transarterial embolization in hepatocellular carcinoma.
Liu Q, Fan D, Adah D, Wu Z, Liu R, Yan QT, Zhang Y, Du ZY, Wang D, Li Y, Bao SY, Liu LP
Oncology reports 2018 Nov;40(5):2547-2557
Oncology reports 2018 Nov;40(5):2547-2557
Synchronous delivery of oxygen and photosensitizer for alleviation of hypoxia tumor microenvironment and dramatically enhanced photodynamic therapy.
Guo X, Qu J, Zhu C, Li W, Luo L, Yang J, Yin X, Li Q, Du Y, Chen D, Qiu Y, Lou Y, You J
Drug delivery 2018 Nov;25(1):585-599
Drug delivery 2018 Nov;25(1):585-599
Biofabricated Structures Reconstruct Functional Urinary Bladders in Radiation-Injured Rat Bladders.
Imamura T, Shimamura M, Ogawa T, Minagawa T, Nagai T, Silwal Gautam S, Ishizuka O
Tissue engineering. Part A 2018 Nov;24(21-22):1574-1587
Tissue engineering. Part A 2018 Nov;24(21-22):1574-1587
Hypoxic tumor therapy by hemoglobin-mediated drug delivery and reversal of hypoxia-induced chemoresistance.
Yang J, Li W, Luo L, Jiang M, Zhu C, Qin B, Yin H, Yuan X, Yin X, Zhang J, Luo Z, Du Y, You J
Biomaterials 2018 Nov;182:145-156
Biomaterials 2018 Nov;182:145-156
Donor Treatment With a Hypoxia-Inducible Factor-1 Agonist Prevents Donation After Cardiac Death Liver Graft Injury in a Rat Isolated Perfusion Model.
Zhang X, Liu Z, Xiao Q, Zeng C, Lai CH, Fan X, Ye Q, Wang Y, Xiong Y
Artificial organs 2018 Mar;42(3):280-289
Artificial organs 2018 Mar;42(3):280-289
Transcriptional Regulation of the Warburg Effect in Cancer by SIX1.
Li L, Liang Y, Kang L, Liu Y, Gao S, Chen S, Li Y, You W, Dong Q, Hong T, Yan Z, Jin S, Wang T, Zhao W, Mai H, Huang J, Han X, Ji Q, Song Q, Yang C, Zhao S, Xu X, Ye Q
Cancer cell 2018 Mar 12;33(3):368-385.e7
Cancer cell 2018 Mar 12;33(3):368-385.e7
Hypoxia-Inducible Factor-1α (HIF-1α) Expression on Endothelial Cells in Juvenile Nasopharyngeal Angiofibroma: A Review of 70 cases and Tissue Microarray Analysis.
Song X, Yang C, Zhang H, Wang J, Sun X, Hu L, Liu Z, Wang D
The Annals of otology, rhinology, and laryngology 2018 Jun;127(6):357-366
The Annals of otology, rhinology, and laryngology 2018 Jun;127(6):357-366
Klotho negatively regulated aerobic glycolysis in colorectal cancer via ERK/HIF1α axis.
Li Q, Li Y, Liang L, Li J, Luo D, Liu Q, Cai S, Li X
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
Cell communication and signaling : CCS 2018 Jun 8;16(1):26
V-ATPase-dependent repression of androgen receptor in prostate cancer cells.
Licon-Munoz Y, Fordyce CA, Hayek SR, Parra KJ
Oncotarget 2018 Jun 22;9(48):28921-28934
Oncotarget 2018 Jun 22;9(48):28921-28934
Anti-glioma Efficacy and Mechanism of Action of Tripolinolate A from Tripolium pannonicum.
Chai W, Chen L, Lian XY, Zhang Z
Planta medica 2018 Jul;84(11):786-794
Planta medica 2018 Jul;84(11):786-794
Metformin synergistically suppress tumor growth with doxorubicin and reverse drug resistance by inhibiting the expression and function of P-glycoprotein in MCF7/ADR cells and xenograft models.
Li Y, Wang M, Zhi P, You J, Gao JQ
Oncotarget 2018 Jan 5;9(2):2158-2174
Oncotarget 2018 Jan 5;9(2):2158-2174
Oroxylin A prevents angiogenesis of LSECs in liver fibrosis via inhibition of YAP/HIF-1α signaling.
Zhang C, Bian M, Chen X, Jin H, Zhao S, Yang X, Shao J, Chen A, Guo Q, Zhang F, Zheng S
Journal of cellular biochemistry 2018 Feb;119(2):2258-2268
Journal of cellular biochemistry 2018 Feb;119(2):2258-2268
TCF7L2 positively regulates aerobic glycolysis via the EGLN2/HIF-1α axis and indicates prognosis in pancreatic cancer.
Xiang J, Hu Q, Qin Y, Ji S, Xu W, Liu W, Shi S, Liang C, Liu J, Meng Q, Liang D, Ni Q, Xu J, Zhang B, Yu X
Cell death & disease 2018 Feb 23;9(3):321
Cell death & disease 2018 Feb 23;9(3):321
Hypoxia Activates Src and Promotes Endocytosis Which Decreases MMP-2 Activity and Aggravates Renal Interstitial Fibrosis.
Cheng Z, Liu L, Wang Z, Cai Y, Xu Q, Chen P
International journal of molecular sciences 2018 Feb 15;19(2)
International journal of molecular sciences 2018 Feb 15;19(2)
Resveratrol inhibits VEGF-induced angiogenesis in human endothelial cells associated with suppression of aerobic glycolysis via modulation of PKM2 nuclear translocation.
Wu H, He L, Shi J, Hou X, Zhang H, Zhang X, An Q, Fan F
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
Clinical and experimental pharmacology & physiology 2018 Dec;45(12):1265-1273
Metformin suppresses hypoxia‑induced migration via the HIF‑1α/VEGF pathway in gallbladder cancer in vitro and in vivo.
Ye J, Chen K, Qi L, Li R, Tang H, Zhou C, Zhai W
Oncology reports 2018 Dec;40(6):3501-3510
Oncology reports 2018 Dec;40(6):3501-3510
Radiosensitizing effects of miR-18a-5p on lung cancer stem-like cells via downregulating both ATM and HIF-1α.
Chen X, Wu L, Li D, Xu Y, Zhang L, Niu K, Kong R, Gu J, Xu Z, Chen Z, Sun J
Cancer medicine 2018 Aug;7(8):3834-3847
Cancer medicine 2018 Aug;7(8):3834-3847
ANXA2 promotes esophageal cancer progression by activating MYC-HIF1A-VEGF axis.
Ma S, Lu CC, Yang LY, Wang JJ, Wang BS, Cai HQ, Hao JJ, Xu X, Cai Y, Zhang Y, Wang MR
Journal of experimental & clinical cancer research : CR 2018 Aug 6;37(1):183
Journal of experimental & clinical cancer research : CR 2018 Aug 6;37(1):183
Phosphoglycerate Mutase 1 (PGAM1) Promotes Pancreatic Ductal Adenocarcinoma (PDAC) Metastasis by Acting as a Novel Downstream Target of the PI3K/Akt/mTOR Pathway.
Liu X, Tan X, Liu P, Wu Y, Qian S, Zhang X
Oncology research 2018 Aug 23;26(7):1123-1131
Oncology research 2018 Aug 23;26(7):1123-1131
Mini-peptide RPL41 attenuated retinal neovascularization by inducing degradation of ATF4 in oxygen-induced retinopathy mice.
Geng W, Qin F, Ren J, Xiao S, Wang A
Experimental cell research 2018 Aug 15;369(2):243-250
Experimental cell research 2018 Aug 15;369(2):243-250
R-spondin3-LGR4 signaling protects hepatocytes against DMOG-induced hypoxia/reoxygenation injury through activating β-catenin.
Liu S, Yin Y, Yu R, Li Y, Zhang W
Biochemical and biophysical research communications 2018 Apr 30;499(1):59-65
Biochemical and biophysical research communications 2018 Apr 30;499(1):59-65
Targeting tumor hypoxia with stimulus-responsive nanocarriers in overcoming drug resistance and monitoring anticancer efficacy.
Xie Z, Guo W, Guo N, Huangfu M, Liu H, Lin M, Xu W, Chen J, Wang T, Wei Q, Han M, Gao J
Acta biomaterialia 2018 Apr 15;71:351-362
Acta biomaterialia 2018 Apr 15;71:351-362
Downregulation of Mitochondrial Single Stranded DNA Binding Protein (SSBP1) Induces Mitochondrial Dysfunction and Increases the Radiosensitivity in Non-Small Cell Lung Cancer Cells.
Wang Y, Hu L, Zhang X, Zhao H, Xu H, Wei Y, Jiang H, Xie C, Zhou Y, Zhou F
Journal of Cancer 2017;8(8):1400-1409
Journal of Cancer 2017;8(8):1400-1409
A Human Long Non-Coding RNA ALT1 Controls the Cell Cycle of Vascular Endothelial Cells Via ACE2 and Cyclin D1 Pathway.
Li W, Wang R, Ma JY, Wang M, Cui J, Wu WB, Liu RM, Zhang CX, Li W, Wang SM
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2017;43(3):1152-1167
Lyophilized Powder of Catalpol and Puerarin Protected Cerebral Vessels from Ischemia by Its Anti-apoptosis on Endothelial Cells.
Liu Y, Tang Q, Shao S, Chen Y, Chen W, Xu X
International journal of biological sciences 2017;13(3):327-338
International journal of biological sciences 2017;13(3):327-338
Macrophage migration inhibitory factor promotes vasculogenic mimicry formation induced by hypoxia via CXCR4/AKT/EMT pathway in human glioblastoma cells.
Guo X, Xu S, Gao X, Wang J, Xue H, Chen Z, Zhang J, Guo X, Qian M, Qiu W, Li G
Oncotarget 2017 Oct 6;8(46):80358-80372
Oncotarget 2017 Oct 6;8(46):80358-80372
Gli1 is a potential cancer stem cell marker and predicts poor prognosis in ductal breast carcinoma.
Ni W, Yang Z, Qi W, Cui C, Cui Y, Xuan Y
Human pathology 2017 Nov;69:38-45
Human pathology 2017 Nov;69:38-45
Codelivery for Paclitaxel and Bcl-2 Conversion Gene by PHB-PDMAEMA Amphiphilic Cationic Copolymer for Effective Drug Resistant Cancer Therapy.
Wang X, Liow SS, Wu Q, Li C, Owh C, Li Z, Loh XJ, Wu YL
Macromolecular bioscience 2017 Nov;17(11)
Macromolecular bioscience 2017 Nov;17(11)
HIF-1α/Ascl2/miR-200b regulatory feedback circuit modulated the epithelial-mesenchymal transition (EMT) in colorectal cancer cells.
Shang Y, Chen H, Ye J, Wei X, Liu S, Wang R
Experimental cell research 2017 Nov 15;360(2):243-256
Experimental cell research 2017 Nov 15;360(2):243-256
A new facet of NDRG1 in pancreatic ductal adenocarcinoma: Suppression of glycolytic metabolism.
Liu W, Zhang B, Hu Q, Qin Y, Xu W, Shi S, Liang C, Meng Q, Xiang J, Liang D, Ji S, Liu J, Hu P, Liu L, Liu C, Long J, Ni Q, Yu X, Xu J
International journal of oncology 2017 May;50(5):1792-1800
International journal of oncology 2017 May;50(5):1792-1800
BNIP3 promotes the motility and migration of keratinocyte under hypoxia.
Zhang J, Zhang D, Yan T, Jiang X, Zhang C, Zhao L, Li L, Tang D, Zhang Q, Jia J, Zhang J, Huang Y
Experimental dermatology 2017 May;26(5):416-422
Experimental dermatology 2017 May;26(5):416-422
In vivo evaluation of the effects of simultaneous inhibition of GLUT-1 and HIF-1α by antisense oligodeoxynucleotides on the radiosensitivity of laryngeal carcinoma using micro 18F-FDG PET/CT.
Shen LF, Zhao X, Zhou SH, Lu ZJ, Zhao K, Fan J, Zhou ML
Oncotarget 2017 May 23;8(21):34709-34726
Oncotarget 2017 May 23;8(21):34709-34726
Canonical hedgehog signalling regulates hepatic stellate cell-mediated angiogenesis in liver fibrosis.
Zhang F, Hao M, Jin H, Yao Z, Lian N, Wu L, Shao J, Chen A, Zheng S
British journal of pharmacology 2017 Mar;174(5):409-423
British journal of pharmacology 2017 Mar;174(5):409-423
Notch1 Signaling Contributes to Hypoxia-induced High Expression of Integrin β1 in Keratinocyte Migration.
Tang D, Yan T, Zhang J, Jiang X, Zhang D, Huang Y
Scientific reports 2017 Mar 7;7:43926
Scientific reports 2017 Mar 7;7:43926
Discordant mRNA and protein expression of CXCR4 under in vitro CoCl(2)-induced hypoxic conditions.
Tang M, Yang Y, Yu J, Wu N, Chen P, Xu L, Wang Q, Xu Z, Ge J, Yu K, Zhuang J
Biochemical and biophysical research communications 2017 Mar 4;484(2):285-291
Biochemical and biophysical research communications 2017 Mar 4;484(2):285-291
Regulation of angiogenic behaviors by oxytocin receptor through Gli1-indcued transcription of HIF-1α in human umbilical vein endothelial cells.
Zhu J, Wang H, Zhang X, Xie Y
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jun;90:928-934
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2017 Jun;90:928-934
Conjugation of gold nanoparticles and recombinant human endostatin modulates vascular normalization via interruption of anterior gradient 2-mediated angiogenesis.
Pan F, Yang W, Li W, Yang XY, Liu S, Li X, Zhao X, Ding H, Qin L, Pan Y
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317708547
Tumour biology : the journal of the International Society for Oncodevelopmental Biology and Medicine 2017 Jul;39(7):1010428317708547
Polyoxometalate-Based Radiosensitization Platform for Treating Hypoxic Tumors by Attenuating Radioresistance and Enhancing Radiation Response.
Yong Y, Zhang C, Gu Z, Du J, Guo Z, Dong X, Xie J, Zhang G, Liu X, Zhao Y
ACS nano 2017 Jul 25;11(7):7164-7176
ACS nano 2017 Jul 25;11(7):7164-7176
Endothelial progenitor cells transplantation attenuated blood-brain barrier damage after ischemia in diabetic mice via HIF-1α.
Geng J, Wang L, Qu M, Song Y, Lin X, Chen Y, Mamtilahun M, Chen S, Zhang Z, Wang Y, Yang GY
Stem cell research & therapy 2017 Jul 11;8(1):163
Stem cell research & therapy 2017 Jul 11;8(1):163
Long non-coding RNA LINC00152 promotes gallbladder cancer metastasis and epithelial-mesenchymal transition by regulating HIF-1α via miR-138.
Cai Q, Wang Z, Wang S, Weng M, Zhou D, Li C, Wang J, Chen E, Quan Z
Open biology 2017 Jan;7(1)
Open biology 2017 Jan;7(1)
The Promoting Effect of Radiation on Glucose Metabolism in Breast Cancer Cells under the Treatment of Cobalt Chloride.
Zhao CB, Shi L, Pu HH, Zhang QY
Pathology oncology research : POR 2017 Jan;23(1):47-53
Pathology oncology research : POR 2017 Jan;23(1):47-53
Antiangiogenic Effects of Doxazosin on Experimental Choroidal Neovascularization in Mice.
Guo J, Luo X, Liang J, Xiao M, Sun X
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2017 Jan Feb;33(1):50-56
Journal of ocular pharmacology and therapeutics : the official journal of the Association for Ocular Pharmacology and Therapeutics 2017 Jan Feb;33(1):50-56
Nrf2 Activation Is Required for Ligustrazine to Inhibit Hepatic Steatosis in Alcohol-Preferring Mice and Hepatocytes.
Lu C, Xu W, Shao J, Zhang F, Chen A, Zheng S
Toxicological sciences : an official journal of the Society of Toxicology 2017 Feb;155(2):432-443
Toxicological sciences : an official journal of the Society of Toxicology 2017 Feb;155(2):432-443
Expression of HMGB2 indicates worse survival of patients and is required for the maintenance of Warburg effect in pancreatic cancer.
Cai X, Ding H, Liu Y, Pan G, Li Q, Yang Z, Liu W
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
Acta biochimica et biophysica Sinica 2017 Feb 6;49(2):119-127
RBM4 Regulates Neuronal Differentiation of Mesenchymal Stem Cells by Modulating Alternative Splicing of Pyruvate Kinase M.
Su CH, Hung KY, Hung SC, Tarn WY
Molecular and cellular biology 2017 Feb 1;37(3)
Molecular and cellular biology 2017 Feb 1;37(3)
Neutrophils and Snail Orchestrate the Establishment of a Pro-tumor Microenvironment in Lung Cancer.
Faget J, Groeneveld S, Boivin G, Sankar M, Zangger N, Garcia M, Guex N, Zlobec I, Steiner L, Piersigilli A, Xenarios I, Meylan E
Cell reports 2017 Dec 12;21(11):3190-3204
Cell reports 2017 Dec 12;21(11):3190-3204
Preparation of artificial red cell and its application on alleviation of tumor hypoxia.
Qu J, Guo X, Li W, Hou W, Zhang H, Luo L, Zhu C, Yang J, Yin X, Tao Y, Du Y, Lou Y, Chen D, You J
Colloids and surfaces. B, Biointerfaces 2017 Dec 1;160:446-454
Colloids and surfaces. B, Biointerfaces 2017 Dec 1;160:446-454
Macrophages Regulate Unilateral Ureteral Obstruction-Induced Renal Lymphangiogenesis through C-C Motif Chemokine Receptor 2-Dependent Phosphatidylinositol 3-Kinase-AKT-Mechanistic Target of Rapamycin Signaling and Hypoxia-Inducible Factor-1α/Vascular Endothelial Growth Factor-C Expression.
Guo YC, Zhang M, Wang FX, Pei GC, Sun F, Zhang Y, He X, Wang Y, Song J, Zhu FM, Pandupuspitasari NS, Liu J, Huang K, Yang P, Xiong F, Zhang S, Yu Q, Yao Y, Wang CY
The American journal of pathology 2017 Aug;187(8):1736-1749
The American journal of pathology 2017 Aug;187(8):1736-1749
Effect of a hypoxic microenvironment after radiofrequency ablation on residual hepatocellular cell migration and invasion.
Tong Y, Yang H, Xu X, Ruan J, Liang M, Wu J, Luo B
Cancer science 2017 Apr;108(4):753-762
Cancer science 2017 Apr;108(4):753-762
Non-benzoquinone geldanamycin analogs trigger various forms of death in human breast cancer cells.
Zhang Z, Li HM, Zhou C, Li Q, Ma L, Zhang Z, Sun Y, Wang L, Zhang X, Zhu B, Hong YS, Wu CZ, Liu H
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
Journal of experimental & clinical cancer research : CR 2016 Sep 22;35(1):149
The critical role of mast cell-derived hypoxia-inducible factor-1α in regulating mast cell function.
Liang X, Yin G, Ma Y, Xu K, Liu J, Li J
The Journal of pharmacy and pharmacology 2016 Nov;68(11):1409-1416
The Journal of pharmacy and pharmacology 2016 Nov;68(11):1409-1416
Hydrogen Sulfide and Carbon Monoxide Protect Gastric Mucosa Compromised by Mild Stress Against Alendronate Injury.
Magierowski M, Magierowska K, Szmyd J, Surmiak M, Sliwowski Z, Kwiecien S, Brzozowski T
Digestive diseases and sciences 2016 Nov;61(11):3176-3189
Digestive diseases and sciences 2016 Nov;61(11):3176-3189
Inhibition of peritoneal metastasis of human gastric cancer cells by dextran sulphate through the reduction in HIF-1α and ITGβ1 expression.
Xu Y, Jin X, Huang Y, Dong J, Wang H, Wang X, Cao X
Oncology reports 2016 May;35(5):2624-34
Oncology reports 2016 May;35(5):2624-34
Association between the expression of HIF-1α and VEGF and prognostic implications in primary liver cancer.
Guo LY, Zhu P, Jin XP
Genetics and molecular research : GMR 2016 May 9;15(2)
Genetics and molecular research : GMR 2016 May 9;15(2)
Arginine ADP-ribosyltransferase 1 promotes angiogenesis in colorectal cancer via the PI3K/Akt pathway.
Yang L, Xiao M, Li X, Tang Y, Wang YL
International journal of molecular medicine 2016 Mar;37(3):734-42
International journal of molecular medicine 2016 Mar;37(3):734-42
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
Li P, Zhang D, Shen L, Dong K, Wu M, Ou Z, Shi D
Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
Quercetin alleviates pulmonary angiogenesis in a rat model of hepatopulmonary syndrome.
Li X, Chen Y, Wang L, Shang G, Zhang C, Zhao Z, Zhang H, Liu A
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016 Jul 4;49(7)
Brazilian journal of medical and biological research = Revista brasileira de pesquisas medicas e biologicas 2016 Jul 4;49(7)
Gold Nanoparticle-Mediated Targeted Delivery of Recombinant Human Endostatin Normalizes Tumour Vasculature and Improves Cancer Therapy.
Li W, Zhao X, Du B, Li X, Liu S, Yang XY, Ding H, Yang W, Pan F, Wu X, Qin L, Pan Y
Scientific reports 2016 Jul 29;6:30619
Scientific reports 2016 Jul 29;6:30619
KLF5 mediates vascular remodeling via HIF-1α in hypoxic pulmonary hypertension.
Li X, He Y, Xu Y, Huang X, Liu J, Xie M, Liu X
American journal of physiology. Lung cellular and molecular physiology 2016 Feb 15;310(4):L299-310
American journal of physiology. Lung cellular and molecular physiology 2016 Feb 15;310(4):L299-310
Interaction between endogenous carbon monoxide and hydrogen sulfide in the mechanism of gastroprotection against acute aspirin-induced gastric damage.
Magierowski M, Magierowska K, Hubalewska-Mazgaj M, Adamski J, Bakalarz D, Sliwowski Z, Pajdo R, Kwiecien S, Brzozowski T
Pharmacological research 2016 Dec;114:235-250
Pharmacological research 2016 Dec;114:235-250
Inhibition of p38 mitogen-activated protein kinases attenuates renal interstitial fibrosis in a murine unilateral ureteral occlusion model.
Gao F, Wang Y, Li S, Wang Z, Liu C, Sun D
Life sciences 2016 Dec 15;167:78-84
Life sciences 2016 Dec 15;167:78-84
Paper-based microreactor array for rapid screening of cell signaling cascades.
Huang CH, Lei KF, Tsang NM
Lab on a chip 2016 Aug 7;16(15):2911-20
Lab on a chip 2016 Aug 7;16(15):2911-20
ROS-mediated glucose metabolic reprogram induces insulin resistance in type 2 diabetes.
Dong K, Ni H, Wu M, Tang Z, Halim M, Shi D
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
Biochemical and biophysical research communications 2016 Aug 5;476(4):204-211
MicroRNA-421 regulated by HIF-1α promotes metastasis, inhibits apoptosis, and induces cisplatin resistance by targeting E-cadherin and caspase-3 in gastric cancer.
Ge X, Liu X, Lin F, Li P, Liu K, Geng R, Dai C, Lin Y, Tang W, Wu Z, Chang J, Lu J, Li J
Oncotarget 2016 Apr 26;7(17):24466-82
Oncotarget 2016 Apr 26;7(17):24466-82
The DEK oncogene activates VEGF expression and promotes tumor angiogenesis and growth in HIF-1α-dependent and -independent manners.
Zhang Y, Liu J, Wang S, Luo X, Li Y, Lv Z, Zhu J, Lin J, Ding L, Ye Q
Oncotarget 2016 Apr 26;7(17):23740-56
Oncotarget 2016 Apr 26;7(17):23740-56
Dynamic metabolic change is indicative of inflammation-induced transformation of hepatic cells.
Peng B, Liu F, Han R, Luo G, Cathopoulis T, Lu K, Li X, Yang L, Liu GY, Cai JC, Shi SL
The international journal of biochemistry & cell biology 2015 Sep;66:45-58
The international journal of biochemistry & cell biology 2015 Sep;66:45-58
The oncoprotein HBXIP promotes glucose metabolism reprogramming via downregulating SCO2 and PDHA1 in breast cancer.
Liu F, Zhang W, You X, Liu Y, Li Y, Wang Z, Wang Y, Zhang X, Ye L
Oncotarget 2015 Sep 29;6(29):27199-213
Oncotarget 2015 Sep 29;6(29):27199-213
MiR-373 drives the epithelial-to-mesenchymal transition and metastasis via the miR-373-TXNIP-HIF1α-TWIST signaling axis in breast cancer.
Chen D, Dang BL, Huang JZ, Chen M, Wu D, Xu ML, Li R, Yan GR
Oncotarget 2015 Oct 20;6(32):32701-12
Oncotarget 2015 Oct 20;6(32):32701-12
Transarterial chemoembolization aggravated peritumoral fibrosis via hypoxia-inducible factor-1α dependent pathway in hepatocellular carcinoma.
Qu K, Yan Z, Wu Y, Chen Y, Qu P, Xu X, Yuan P, Huang X, Xing J, Zhang H, Liu C, Zhang J
Journal of gastroenterology and hepatology 2015 May;30(5):925-32
Journal of gastroenterology and hepatology 2015 May;30(5):925-32
Antivascular ultrasound therapy: magnetic resonance imaging validation and activation of the immune response in murine melanoma.
Hunt SJ, Gade T, Soulen MC, Pickup S, Sehgal CM
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2015 Feb;34(2):275-87
Journal of ultrasound in medicine : official journal of the American Institute of Ultrasound in Medicine 2015 Feb;34(2):275-87
DEC2 expression is positively correlated with HIF-1 activation and the invasiveness of human osteosarcomas.
Hu T, He N, Yang Y, Yin C, Sang N, Yang Q
Journal of experimental & clinical cancer research : CR 2015 Feb 28;34(1):22
Journal of experimental & clinical cancer research : CR 2015 Feb 28;34(1):22
Low-Dose Cadmium Upregulates VEGF Expression in Lung Adenocarcinoma Cells.
Liu F, Wang B, Li L, Dong F, Chen X, Li Y, Dong X, Wada Y, Kapron CM, Liu J
International journal of environmental research and public health 2015 Aug 28;12(9):10508-21
International journal of environmental research and public health 2015 Aug 28;12(9):10508-21
mTORC1/2 targeted by n-3 polyunsaturated fatty acids in the prevention of mammary tumorigenesis and tumor progression.
Chen Z, Zhang Y, Jia C, Wang Y, Lai P, Zhou X, Wang Y, Song Q, Lin J, Ren Z, Gao Q, Zhao Z, Zheng H, Wan Z, Gao T, Zhao A, Dai Y, Bai X
Oncogene 2014 Sep 11;33(37):4548-57
Oncogene 2014 Sep 11;33(37):4548-57
The oncoprotein HBXIP enhances angiogenesis and growth of breast cancer through modulating FGF8 and VEGF.
Liu F, You X, Wang Y, Liu Q, Liu Y, Zhang S, Chen L, Zhang X, Ye L
Carcinogenesis 2014 May;35(5):1144-53
Carcinogenesis 2014 May;35(5):1144-53
Role of microRNA-27a in down-regulation of angiogenic factor AGGF1 under hypoxia associated with high-grade bladder urothelial carcinoma.
Xu Y, Zhou M, Wang J, Zhao Y, Li S, Zhou B, Su Z, Xu C, Xia Y, Qian H, Tu X, Xiao W, Chen X, Chen Q, Wang QK
Biochimica et biophysica acta 2014 May;1842(5):712-25
Biochimica et biophysica acta 2014 May;1842(5):712-25
Interferon-γ-induced intestinal epithelial barrier dysfunction by NF-κB/HIF-1α pathway.
Yang S, Yu M, Sun L, Xiao W, Yang X, Sun L, Zhang C, Ma Y, Yang H, Liu Y, Lu D, Teitelbaum DH, Yang H
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Mar;34(3):195-203
Journal of interferon & cytokine research : the official journal of the International Society for Interferon and Cytokine Research 2014 Mar;34(3):195-203
Hyperthermia-conditioned OECs serum-free-conditioned medium induce NSC differentiation into neuron more efficiently by the upregulation of HIF-1 alpha and binding activity.
Wang L, Jiang M, Duan D, Zhao Z, Ge L, Teng X, Liu B, Liu B, Chen P, Lu M
Transplantation 2014 Jun 27;97(12):1225-32
Transplantation 2014 Jun 27;97(12):1225-32
Upregulation of stromal cell-derived factor 1α expression is associated with the resistance to neoadjuvant chemoradiotherapy of locally advanced rectal cancer: angiogenic markers of neoadjuvant chemoradiation.
Kim HJ, Bae SB, Jeong D, Kim ES, Kim CN, Park DG, Ahn TS, Cho SW, Shin EJ, Lee MS, Baek MJ
Oncology reports 2014 Dec;32(6):2493-500
Oncology reports 2014 Dec;32(6):2493-500
Brucine, an alkaloid from seeds of Strychnos nux-vomica Linn., represses hepatocellular carcinoma cell migration and metastasis: the role of hypoxia inducible factor 1 pathway.
Shu G, Mi X, Cai J, Zhang X, Yin W, Yang X, Li Y, Chen L, Deng X
Toxicology letters 2013 Oct 24;222(2):91-101
Toxicology letters 2013 Oct 24;222(2):91-101
Necrosis degree displayed in computed tomography images correlated with hypoxia and angiogenesis in breast cancer.
Shan X, Wang D, Chen J, Xiao X, Jiang Y, Wang Y, Fan Y
Journal of computer assisted tomography 2013 Jan-Feb;37(1):22-8
Journal of computer assisted tomography 2013 Jan-Feb;37(1):22-8
PROX1 promotes hepatocellular carcinoma metastasis by way of up-regulating hypoxia-inducible factor 1α expression and protein stability.
Liu Y, Zhang JB, Qin Y, Wang W, Wei L, Teng Y, Guo L, Zhang B, Lin Z, Liu J, Ren ZG, Ye QH, Xie Y
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
Hepatology (Baltimore, Md.) 2013 Aug;58(2):692-705
FHL family members suppress vascular endothelial growth factor expression through blockade of dimerization of HIF1α and HIF1β.
Lin J, Qin X, Zhu Z, Mu J, Zhu L, Wu K, Jiao H, Xu X, Ye Q
IUBMB life 2012 Nov;64(11):921-30
IUBMB life 2012 Nov;64(11):921-30
Valsartan inhibited HIF-1α pathway and attenuated renal interstitial fibrosis in streptozotocin-diabetic rats.
Tang L, Yi R, Yang B, Li H, Chen H, Liu Z
Diabetes research and clinical practice 2012 Jul;97(1):125-31
Diabetes research and clinical practice 2012 Jul;97(1):125-31
No comments: Submit comment
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Whole cell lysate from HeLa cells that were either treated with cobalt chloride (+; 150 uM) or mock treated (-) and were subjected to SDS PAGE followed by western blot with 20960-1-AP( HIF1a Antibody) at dilution of 1:300.
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of Hela cells, using HIF1A antibody 20960-1-AP at 1:25 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human thyroid cancer using 20960-1-AP(HIF1A antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human thyroid cancer using 20960-1-AP(HIF1A antibody) at dilution of 1:50 (under 40x lens)
- Sample type
- tissue
