51065-1-AP

antibody from Proteintech Group

Targeting: GSK3B

Provider product page for 51065-1-AP

Western blot

ELISA

Immunocytochemistry

Immunoprecipitation

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunocytochemistry [1]
Immunohistochemistry [2]

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Product number: 51065-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#51065-1-AP, RRID:AB_2232770
Product name: GSK3B antibody
Antibody type: Polyclonal
Description: KD/KO validated GSK3B antibody (Cat. #51065-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
Reactivity: Human, Mouse
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

GSK3B protein structure - 51065-1-AP shown in red.

Submitted references Asiatic Acid Ameliorates MNNG-Induced Chronic Atrophic Gastritis by Inhibiting the Activation of the HRAS/PI3K/AKT/GSK3β Signaling Axis.

Zhou F, Zhu C, Yuan W, Peng W, Xu Q, Yang H, Cao R, Wang B, Wang M, Xu H
Phytotherapy research : PTR 2026 May;40(5):2210-2229

Astrocytic PYGM attenuates tau pathology by promoting lactate-mediated neuroprotection.

Cao J, Meng J, Chen Y, Tang Z, Wang Y, Li K, Zhang X, Luo H, Li H, Wang Z, Zhang YW
Alzheimer's & dementia : the journal of the Alzheimer's Association 2026 Feb;22(2):e71202

Frizzled-4 promotes bone formation in chickens via activation of the canonical Wnt signaling pathway.

Liu X, Guo Y, Zhou E, An Z, Li W, Cui P, Jin W, Guo Y, Zhang Y, Li G, Tian W, Li Z, Kang X, Han R
Poultry science 2026 Apr;105(4):106589

Quercetin Improves Hippocampal Neurogenesis in Depression by Regulating the Level of Let-7e-5p in Microglia Exosomes.

Xie Y, Ouyang T, Xu A, Bian Q, Zhu B, Zhao M
Drug design, development and therapy 2025;19:2189-2203

Synergistic exacerbation of periprosthetic osteolysis by inflammatory bowel disease and titanium ions: Impaired osteogenesis of BMSCs via PI3K/AKT signaling.

Ming P, Li K, Zhu W
Materials today. Bio 2025 Oct;34:102236

Microcystin-LR disrupts ovarian granulosa cell glycolysis via GSK3β-Mediated HK2 mitochondrial dissociation: Evidence from integrated In Vivo and In Vitro models.

Yuan J, Li X, Yan S, Luo C, Xian S, Li Y, Wu J
Reproductive toxicology (Elmsford, N.Y.) 2025 Oct;137:109028

TRIM21 as a potential prognostic biomarker and therapeutic target affects the growth of pancreatic cancer.

Sun D, Zheng S, Wang S, Xue Y, Song S, Bai Y, Li X, Ci Y
Discover oncology 2025 Oct 30;16(1):1993

FMRP attenuates Tau pathology through the CDK5/p35 signaling pathway.

Zhao S, Jiang X, Jiang Y, Meng J, Han L, Cao J, Zhu M, Zhou Y, Zhang X, Luo H, Zhang YW, Li H
Neurobiology of disease 2025 Nov;216:107145

Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies.

Zhou Y, Wang Y, Yang H, Zhang C, Meng J, Zhang L, Li K, Huang LL, Zhang X, Luo H, Zhang Y
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5817-5831

Mapping the hippocampal spatial proteomic signature in male and female mice of an early Alzheimer's disease model.

Contreras A, Jiménez-Herrera R, Djebari S, Navarro-López JD, Jiménez-Díaz L
Biology of sex differences 2025 May 25;16(1):36

Interaction of osteopontin with α-lactalbumin and their synergistic effects in protecting intestinal barrier injury.

He W, Wang X, Zhang J, Cao H, Ren S, Sun X, Yu H, Zhang G, Li C, Liu L, Wang C, He J
Food research international (Ottawa, Ont.) 2025 Jun;211:116513

TMEM59 deficiency activates chaperone-mediated autophagy and ameliorates disease-like pathologies in tauopathy model mice.

Zheng N, Wang Z, Cao J, Li K, Xu H, Wang J, Zhang L, Meng J, Tang Z, Luo H, Sun H, Zhang X, Zhang YW
Alzheimer's & dementia : the journal of the Alzheimer's Association 2025 Jun;21(6):e70369

The JAK1/STAT3 pathway mediates the effects of SERPINH1 on glioma EMT.

Wang S, Sun Z, Wang C, Zhang A, Zhang C, Hou S, Lin N, Li Q
International immunopharmacology 2025 Jun 5;157:114731

Analysis of mRNA Pentatricopeptide Repeat Domain 1 as a prospective oncogene in clear cell renal cell carcinoma that accelerates tumor cells proliferation and invasion via the Akt/GSK3β/β-catenin pathway.

Zhou Z, Li Y, Chai Y, Zhang Y, Yan P
Discover oncology 2025 Jan 8;16(1):22

Cordycepin Extracted from Cordyceps militaris mitigated CUMS-induced depression of rats via targeting GSK3β/β-catenin signaling pathway.

Wang Y, Deng Y, Feng M, Chen J, Zhong M, Han Z, Zhang Q, Sun Y
Journal of ethnopharmacology 2025 Jan 31;340:119249

Electrophysiology-based screening identifies neuronal HtrA serine peptidase 2 (HTRA2) as a synaptic plasticity regulator participating in tauopathy.

Zheng N, Li K, Cao J, Wang Z, Zhang L, Zhao Z, He J, Wang Y, Zhu X, Chen Y, Meng J, Zhao D, Niu M, Luo H, Zhang X, Sun H, Zhang YW
Translational psychiatry 2025 Jan 10;15(1):5

Comparative Analysis of Egg Yolk Phospholipid Unsaturation and Its Impact on Neural Health in Alzheimer Disease Mice.

Sun Y, Wu Y, Fang B, Li J, Liu Y, Gao H, Zhang M
Foods (Basel, Switzerland) 2025 Feb 26;14(5)

Daurisoline inhibits glycolysis of lung cancer by targeting the AKT-HK2 axis.

Tan SM, Luo L, He YF, Li W, Wan XX
Cancer biology & therapy 2025 Dec;26(1):2442556

p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes.

Li Q, Zhang L, Sun Y, Du Z, Xu S, Wang X, Wei S, Tao Y, Li B, Jiang J, Di G, Huang Y, Xu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70898

2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways.

Hsu C, Zeng JH, Chen L, Chen LJ, Li XW, Yang JZ, Liu Y, Liu JL, Li JH, Li JH, Xie XL, Wang Q
Ecotoxicology and environmental safety 2024 Nov 1;286:117173

Chebulagic acid suppresses gastric cancer by inhibiting the AURKA/β-catenin/Wnt pathway.

Zhao J, Shi Y, Ma Y, Pan L, Wang Y, Yuan L, Dong J, Ying J
Frontiers in pharmacology 2023;14:1143427

AQP8 may affect glioma proliferation and growth by regulating GSK-3β phosphorylation and nuclear transport of β-catenin.

Cai Z, Shen Z, Zhao J, Zhang H, Guo Z, Xia Q, Liang H, Liu J, Tan L, Sheng H, Zhu S
International journal of developmental neuroscience : the official journal of the International Society for Developmental Neuroscience 2023 Jun;83(4):333-345

Isoliquiritigenin Inhibits the Growth of Colorectal Cancer Cells through the ESR2/PI3K/AKT Signalling Pathway.

Luo F, Tang Y, Zheng L, Yang Y, Gao H, Tian S, Chen H, Tang C, Tang S, Man Q, Wu Y
Pharmaceuticals (Basel, Switzerland) 2023 Dec 27;17(1)

N-glycosylation of CD82 at Asn157 is required for suppressing migration and invasion by reversing EMT via Wnt/β-catenin pathway in colon cancer.

Zhu L, Chen Y, Du H, Cong Y, Yan W, Ma K, Huang X
Biochemical and biophysical research communications 2022 Nov 12;629:121-127

RPS23RG1 modulates tau phosphorylation and axon outgrowth through regulating p35 proteasomal degradation.

Zhao D, Zhou Y, Huo Y, Meng J, Xiao X, Han L, Zhang X, Luo H, Can D, Sun H, Huang TY, Wang X, Zhang J, Liu FR, Xu H, Zhang YW
Cell death and differentiation 2021 Jan;28(1):337-348

High glucose impaired estrogen receptor alpha signaling via β-catenin in osteoblastic MC3T3-E1.

Wang R, Gao D, Zhou Y, Chen L, Luo B, Yu Y, Li H, Hu J, Huang Q, He M, Peng W, Luo D
The Journal of steroid biochemistry and molecular biology 2017 Nov;174:276-283

ILK modulates epithelial polarity and matrix formation in hair follicles.

Rudkouskaya A, Welch I, Dagnino L
Molecular biology of the cell 2014 Mar;25(5):620-32

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: HeLa cells were subjected to SDS PAGE followed by western blot with 51065-1-AP(GSK3B antibody) at dilution of 1:1000
Sample type: cell line

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The GSK3B antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human GSK3B. This antibody recognizes human, mouse antigen. The GSK3B antibody has been validated for the following applications: ELISA, WB, IHC, IF analysis.
Appendix: 51065-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 51065-1-AP(GSK3B antibody) at dilution of 1:100 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human prostate cancer using 51065-1-AP(GSK3B antibody) at dilution of 1:100 (under 40x lens)
Sample type: tissue