51077-1-AP

antibody from Proteintech Group

Targeting: AKT1 AKT, PKB, PRKBA, RAC, RAC-alpha

Provider product page for 51077-1-AP

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Antibody data

Antibody Data
Antigen structure
References [31]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 51077-1-AP - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#51077-1-AP, RRID:AB_2242475
Product name: AKT antibody
Antibody type: Polyclonal
Description: KD/KO validated AKT antibody (Cat. #51077-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
Reactivity: Human
Host: Rabbit
Conjugate: Unconjugated
Isotype: IgG
Vial size: 20ul, 150ul

AKT1 protein structure - 51077-1-AP shown in red.

Submitted references IGFBP5 mediates the therapeutic effect of isoliquiritigenin in myocardial ischemia-reperfusion injury via AKT/GLUT4 regulated insulin resistance.

Bai J, Yang SY, Yu SM, Cao Y, Ma CH, Hu XY, Chen X, Song YN, Chen HJ
Frontiers in pharmacology 2025;16:1544869

PRRSV promotes bacterial infection by remodeling actin cytoskeleton and cell membrane proteins.

Liu X, Lv F, Zhu Y, Meng Y, Peng B, Zheng Z, Li Y, Xu L, Feng Y, Zhang J, Xiao S
mBio 2025 Oct 8;16(10):e0194525

Ilicicolin C suppresses the progression of prostate cancer by inhibiting PI3K/AKT/mTOR pathway.

Gan X, Luo X, Chen J, Fang W, Nie M, Lu H, Liu Y, Wang X
Molecular and cellular biochemistry 2025 Feb;480(2):1089-1104

Anticancer activity of Momordica charantia-derived extracellular vesicle-like particle against cervical cancer.

Yin Q, Sun B, Qi X, Wu C, Li M, Wang B, Xu Y, Li S, Huang L, Chen B, Qi S
Tissue & cell 2025 Aug;95:102897

The variant c.274A>G (p.Asn92Asp) in KRT17 in a patient with pachyonychia congenita and a novel clinical feature of acne inversa.

Wang H, Zhu C, Dong L, Wu B, Liu J, Lin L, Lin D, Chen X, Xiao X
Frontiers in genetics 2024;15:1365581

CircCOCH plays a critical role in Hepatocellular carcinoma through modulating miR-450a and activating PI3K/mTOR pathway.

Jiang W, Wang Y, He W, Wang P, Meng P, Zhang S
Translational oncology 2024 Nov;49:102090

Experimental verification about treatment of Bu-Shen-Yi-Jing-Fang in Alzheimer's disease by the analysis of the feasible signaling pathway of network pharmacology.

Hu Y, Hao R, Li D, Lu Y, Yu G
BMC complementary medicine and therapies 2024 Jun 8;24(1):222

Mechanism through which the hsa-circ_0000992- hsa- miR- 936-AKT3 regulatory network promotes the PM(2.5)-induced inflammatory response in human bronchial epithelial cells.

Li JL, Tan Y, Wang QL, Li CX, Hong JC, Wang HJ, Wu Y, Ni C, Peng XW
Ecotoxicology and environmental safety 2024 Jan 15;270:115778

β-Hydroxybutyrate alleviates cartilage senescence through hnRNP A1-mediated up-regulation of PTEN.

Xia G, Wen Z, Zhang L, Huang J, Wang X, Liang C, Cui X, Cao X, Wu S
Experimental gerontology 2023 May;175:112140

Receptor tyrosine kinase C-kit promotes a destructive phenotype of FLS in osteoarthritis via intracellular EMT signaling.

Cao X, Wu S, Wang X, Huang J, Zhang W, Liang C
Molecular medicine (Cambridge, Mass.) 2023 Mar 23;29(1):38

A novel polypeptide encoded by the circular RNA ZKSCAN1 suppresses HCC via degradation of mTOR.

Song R, Ma S, Xu J, Ren X, Guo P, Liu H, Li P, Yin F, Liu M, Wang Q, Yu L, Liu J, Duan B, Rahman NA, Wołczyński S, Li G, Li X
Molecular cancer 2023 Jan 23;22(1):16

CMTM6 overexpression confers trastuzumab resistance in HER2-positive breast cancer.

Xing F, Gao H, Chen G, Sun L, Sun J, Qiao X, Xue J, Liu C
Molecular cancer 2023 Jan 10;22(1):6

Dual network analysis of transcriptome data for discovery of new therapeutic targets in non-small cell lung cancer.

Bai Y, Zhou L, Zhang C, Guo M, Xia L, Tang Z, Liu Y, Deng S
Oncogene 2023 Dec;42(49):3605-3618

Healthy Serum-Derived Exosomes Improve Neurological Outcomes and Protect Blood-Brain Barrier by Inhibiting Endothelial Cell Apoptosis and Reversing Autophagy-Mediated Tight Junction Protein Reduction in Rat Stroke Model.

Huang LY, Song JX, Cai H, Wang PP, Yin QL, Zhang YD, Chen J, Li M, Song JJ, Wang YL, Luo L, Wang W, Qi SH
Frontiers in cellular neuroscience 2022;16:841544

Binding blockade between TLN1 and integrin β1 represses triple-negative breast cancer.

Zhang Y, Sun L, Li H, Ai L, Ma Q, Qiao X, Yang J, Zhang H, Ou X, Wang Y, Chen G, Xue J, Zhu X, Zhao Y, Yang Y, Liu C
eLife 2022 Mar 14;11

α-Terthienyl induces prostate cancer cell death through inhibiting androgen receptor expression.

Gan X, Huang H, Wen J, Liu K, Yang Y, Li X, Fang G, Liu Y, Wang X
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2022 Aug;152:113266

Network pharmacology and molecular docking reveal the effective substances and active mechanisms of Dalbergia Odoriferain protecting against ischemic stroke.

Liu K, Tao X, Su J, Li F, Mu F, Zhao S, Lu X, Li J, Chen S, Dong T, Duan J, Wei P, Xi M
PloS one 2021;16(9):e0255736

Low Expression Levels of SLC22A12 Indicates a Poor Prognosis and Progresses Clear Cell Renal Cell Carcinoma.

Xu J, Liu Y, Liu J, Shou Y, Xiong Z, Xiong H, Xu T, Wang Q, Liu D, Liang H, Yang H, Yang X, Zhang X
Frontiers in oncology 2021;11:659208

Chronic stress promotes glioma cell proliferation via the PI3K/Akt signaling pathway.

Zhang ZQ, Wang X, Xue BH, Zhao Y, Xie F, Wang SD, Xue C, Wang Y, Zhang YS, Qian LJ
Oncology reports 2021 Sep;46(3)

Aronia melanocarpa polysaccharide ameliorates inflammation and aging in mice by modulating the AMPK/SIRT1/NF-κB signaling pathway and gut microbiota.

Zhao Y, Liu X, Zheng Y, Liu W, Ding C
Scientific reports 2021 Oct 18;11(1):20558

Effects of CDKN2B-AS1 on cellular proliferation, invasion and AKT3 expression are attenuated by miR-424-5p in a model of ovarian endometriosis.

Wang S, Yi M, Zhang X, Zhang T, Jiang L, Cao L, Zhou Y, Fang X
Reproductive biomedicine online 2021 Jun;42(6):1057-1066

YTHDF1 promotes hepatocellular carcinoma progression via activating PI3K/AKT/mTOR signaling pathway and inducing epithelial-mesenchymal transition.

Luo X, Cao M, Gao F, He X
Experimental hematology & oncology 2021 Jun 4;10(1):35

NRSN2 promotes breast cancer metastasis by activating PI3K/AKT/mTOR and NF-κB signaling pathways.

Ren F, Zhang W, Lu S, Ren H, Guo Y
Oncology letters 2020 Jan;19(1):813-823

Identification of aberrantly methylated differentially expressed genes in prostate carcinoma using integrated bioinformatics.

Wu K, Yin X, Jin Y, Liu F, Gao J
Cancer cell international 2019;19:51

Interaction between epidermal growth factor receptor and interleukin-6 receptor in NSCLC progression.

Yuquan B, Hexiao T, Laiyi W, Gaofeng P, Xuefeng Z, Ming X, Yanhong W, Li Z, Jinping Z
Journal of cellular biochemistry 2019 Jan;120(1):872-881

Combined detection of estrogen and tumor markers is an important reference factor in the diagnosis and prognosis of lung cancer.

Bai Y, Shen W, Zhu M, Zhang L, Wei Y, Tang H, Zhao J
Journal of cellular biochemistry 2019 Jan;120(1):105-114

Interaction of estrogen receptor β5 and interleukin 6 receptor in the progression of non-small cell lung cancer.

Tang H, Bai Y, Xiong L, Zhang L, Wei Y, Zhu M, Wu X, Long D, Yang J, Yu L, Xu S, Zhao J
Journal of cellular biochemistry 2019 Feb;120(2):2028-2038

Clinical significance of combined detection of interleukin-6 and tumour markers in lung cancer.

Tang H, Bai Y, Shen W, Wei Y, Xu M, Zhou X, Zhao J
Autoimmunity 2018 Jun;51(4):191-198

Oestrogen receptor β5 and epidermal growth factor receptor synergistically promote lung cancer progression.

Bai Y, Shen W, Zhang L, Yang Z, Xiong L, Tang H, Zhao J
Autoimmunity 2018 Jun;51(4):157-165

Interleukin-6 and insulin-like growth factor-1 synergistically promote the progression of NSCLC.

Tang H, Bai Y, Pan G, Wang X, Wei Y, Yang Z, Zhao J
Autoimmunity 2018 Dec;51(8):399-407

Gelsolin-like actin-capping protein is associated with patient prognosis, cellular apoptosis and proliferation in prostate cancer.

Li T, Hong X, Zhao J, Teng Y, Zheng J, Chen H, Chen H, Li H
Biomarkers in medicine 2016 Dec;10(12):1251-1260

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The AKT1 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human AKT1. This antibody recognizes human antigen. The AKT1 antibody has been validated for the following applications: ELISA, IHC, WB analysis.
Appendix: 51077-1-AP.pdf

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 51077-1-AP(AKT1 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 51077-1-AP(AKT1 antibody) at dilution of 1:50 (under 40x lens)
Sample type: tissue