60051-1-Ig

antibody from Proteintech Group

Targeting: ANXA2 ANX2, ANX2L4, CAL1H, LIP2, LPC2D

Western blot (Supportive data in Antibodypedia)

ELISA (Data presented on provider website)

Immunocytochemistry (Supportive data in Antibodypedia)

Immunoprecipitation (Supportive data in Antibodypedia)

Flow cytometry (Data presented on provider website)

Antibody Data

Product number

60051-1-Ig

Provider

Proteintech Group

Proper citation

Proteintech Cat#60051-1-Ig, RRID:AB_2057309

Product name

Annexin A2 antibody

Antibody type

Monoclonal

Description

KD/KO validated Annexin A2 antibody (Cat. #60051-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IP, WB,ELISA.

Reactivity

Human, Mouse, Rat

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Antibody clone number

3H1B11

Vial size

20ul, 150ul

References

Submitted references

Neural stem cell-derived exosomal PA2G4 induces ANXA2 degradation to promote mitophagy and alleviate neuronal oxidative stress in cerebral ischemia/reperfusion.

Dai M, Lu T, Li J, Yu H
Apoptosis : an international journal on programmed cell death 2026 Feb 20;31(3)

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VSIG2 hinders gastric cancer progression by suppressing ANXA2-mediated NF-κB pathway activation.

Ni Q, Wang Y, Bian X, Qu Q, Shen B, Niu Y, Yu J, Zhu J
Acta biochimica et biophysica Sinica 2025 Nov 4;57(11):1834-1846

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Phosphorylation of annexin A2 at serine 25 is required for endothelin-1 stimulated cell proliferation and AKT activation in melanoma cells.

Mazaki Y, Horinouchi T, Onodera Y, Nam JM
Biochemical and biophysical research communications 2025 Jan;743:151168

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The Novel Direct AR Target Gene Annexin A2 Mediates Androgen-Induced Cellular Senescence in Prostate Cancer Cells.

Mirzakhani K, Heidari Horestani M, Kallenbach J, Atri Roozbahani G, Baniahmad A
Biochemical genetics 2025 Dec;63(6):5013-5028

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Annexin A2 stabilizes the endoplasmic reticulum and actin cytoskeleton and influences the formation of reovirus factories.

Tenorio R, Taylor GM, Cayuela A, Sorzano COS, Fernández de Castro I, Fernández-Sánchez SY, Roth AN, Somoulay X, Treadaway GS, Dermody TS, Risco C
Journal of virology 2025 Dec 23;99(12):e0138925

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NudCL2 is required for cytokinesis by stabilizing RCC2 with Hsp90 at the midbody.

Xu X, Huang Y, Yang F, Sun X, Lin R, Feng J, Yang M, Shao J, Liu X, Zhou T, Xie S, Yang Y
Protein & cell 2024 Oct 1;15(10):766-782

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Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits.

Liu X, Min Q, Cheng X, Zhang W, Wu Q, Chen X, Lv M, Liu S, Zhao H, Yang D, Tai Y, Lei X, Wang Y, Zhan Q
British journal of cancer 2024 Nov;131(10):1591-1604

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Opportunistic pathogen Porphyromonas gingivalis targets the LC3B-ceramide complex and mediates lethal mitophagy resistance in oral tumors.

Sheridan M, Chowdhury N, Wellslager B, Oleinik N, Kassir MF, Lee HG, Engevik M, Peterson Y, Pandruvada S, Szulc ZM, Yilmaz Ö, Ogretmen B
iScience 2024 Jun 21;27(6):109860

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Streptococcus anginosus promotes gastric inflammation, atrophy, and tumorigenesis in mice.

Fu K, Cheung AHK, Wong CC, Liu W, Zhou Y, Wang F, Huang P, Yuan K, Coker OO, Pan Y, Chen D, Lam NM, Gao M, Zhang X, Huang H, To KF, Sung JJY, Yu J
Cell 2024 Feb 15;187(4):882-896.e17

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Matrix vesicles from osteoblasts promote atherosclerotic calcification.

Wang X, Ren J, Fang F, Wang E, Li J, He W, Zhang Z, Shen Y, Liu X
Matrix biology : journal of the International Society for Matrix Biology 2024 Dec;134:79-92

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The novel DNA methylation marker FIBIN suppresses non-small cell lung cancer metastasis by negatively regulating ANXA2.

Peng M, Yang L, Liao J, Le X, Dai F, Sun R, Wu F, Jiang Y, Tian R, Shao B, Zhou L, Wu M, Guo S, Xiang T
Cellular signalling 2024 Aug;120:111197

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Upregulation of HDAC9 in hippocampal neurons mediates depression-like behaviours by inhibiting ANXA2 degradation.

Dai Y, Wei T, Huang Y, Bei Y, Lin H, Shen Z, Yu L, Yang M, Xu H, He W, Lin Z, Dai H
Cellular and molecular life sciences : CMLS 2023 Sep 10;80(10):289

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Compounds targeting YadC of uropathogenic Escherichia coli and its host receptor annexin A2 decrease bacterial colonization in bladder.

Li X, Pei G, Zhang L, Cao Y, Wang J, Yu L, Dianjun W, Gao S, Zhang ZS, Yao Z, Wang Q
EBioMedicine 2019 Dec;50:23-33

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The Tick Protein Sialostatin L2 Binds to Annexin A2 and Inhibits NLRC4-Mediated Inflammasome Activation.

Wang X, Shaw DK, Sakhon OS, Snyder GA, Sundberg EJ, Santambrogio L, Sutterwala FS, Dumler JS, Shirey KA, Perkins DJ, Richard K, Chagas AC, Calvo E, Kopecký J, Kotsyfakis M, Pedra JHF
Infection and immunity 2016 Jun;84(6):1796-1805

Western blot

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

K-562 cells were subjected to SDS PAGE followed by western blot with 60051-1-Ig(ANXA2 antibody) at dilution of 1:1000

Sample type

cell line

Immunocytochemistry

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

Immunofluorescent analysis of Hela cells, using ANXA2 antibody 66051-1-lg at 1:25 dilution and Rhodamine-labeled goat anti-mouse IgG (red).

Sample type

cell line

Immunoprecipitation

Supportive validation

Submitted by

Proteintech Group (provider)

Main image

Experimental details

IP Result of anti-Annexin A2 (IP:60051-1-Ig, 4ug; Detection:60051-1-Ig 1:1500) with HeLa cells lysate 2400ug.

Sample type

cell line