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- Antibody Data
- Antigen structure
- References [5]
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- Product number
- ABIN358393 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-Ribosomal Protein S6 Kinase, 90kDa, Polypeptide 1 (RPS6KA1) (pSer363) antibody
- Antibody type
- Polyclonal
- Description
- Affinity purification in a 2-step procedure with the control and phosphorylated peptides. The phospho-specific antibody is eluted with high and low pH buffers and neutralized immediately, followed by dialysis against PBS.
- Reactivity
- Human
- Host
- Rabbit
- Epitope
- pSer363
- Vial size
- 0.4 mL
- Storage
- Store the antibody undiluted at 2-8°C for one month or (in aliquots) at-20°C for longer.
- Handling
- Avoid repeated freezing and thawing.
Submitted references Tumor-promoting phorbol esters and activated Ras inactivate the tuberous sclerosis tumor suppressor complex via p90 ribosomal S6 kinase.
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.
Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt.
90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.
14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.
Roux PP, Ballif BA, Anjum R, Gygi SP, Blenis J
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 14;101(37):13489-94
Proceedings of the National Academy of Sciences of the United States of America 2004 Sep 14;101(37):13489-94
p53 induces NF-kappaB activation by an IkappaB kinase-independent mechanism involving phosphorylation of p65 by ribosomal S6 kinase 1.
Bohuslav J, Chen LF, Kwon H, Mu Y, Greene WC
The Journal of biological chemistry 2004 Jun 18;279(25):26115-25
The Journal of biological chemistry 2004 Jun 18;279(25):26115-25
Estradiol abrogates apoptosis in breast cancer cells through inactivation of BAD: Ras-dependent nongenomic pathways requiring signaling through ERK and Akt.
Fernando RI, Wimalasena J
Molecular biology of the cell 2004 Jul;15(7):3266-84
Molecular biology of the cell 2004 Jul;15(7):3266-84
90-kDa ribosomal S6 kinase is a direct target for the nuclear fibroblast growth factor receptor 1 (FGFR1): role in FGFR1 signaling.
Hu Y, Fang X, Dunham SM, Prada C, Stachowiak EK, Stachowiak MK
The Journal of biological chemistry 2004 Jul 9;279(28):29325-35
The Journal of biological chemistry 2004 Jul 9;279(28):29325-35
14-3-3beta is a p90 ribosomal S6 kinase (RSK) isoform 1-binding protein that negatively regulates RSK kinase activity.
Cavet ME, Lehoux S, Berk BC
The Journal of biological chemistry 2003 May 16;278(20):18376-83
The Journal of biological chemistry 2003 May 16;278(20):18376-83
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