302506

antibody from BioLegend

Targeting: CD22 SIGLEC-2, SIGLEC2

Antibody data

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Validation data

Product number: 302506 - Provider product page
Provider: BioLegend
Proper citation: BioLegend Cat#302506, RRID:AB_2074593
Product name: PE anti-human CD22
Antibody type: Monoclonal
Antigen: CD22
Description: CD22 is a 130 kD type I transmembrane glycoprotein also known as Siglec-2 and BL-CAM. It is a member of the immunoglobulin superfamily (sialoadhesion subgroup). CD22 is expressed in the cytoplasm of pro-B and pre-B cells, and on the surface of mature B and activated B cells, but not on plasma cells. CD22 is present in the B cell receptor complex and associates with SHP-1, Syk, Lck, Lyn, and phospholipase Cγ1. A primary function of CD22 is thought to be in limiting antigen receptor signaling by modulating B cell activation threshold. CD22 has been shown to bind to CD45RO and CD75, although the natural ligands for this molecule remain controversial.
Reactivity: Human, Simian
Host: Mouse
Conjugate: Yellow dye
Isotype: IgG
Vial size: 100 tests
Storage: The antibody solution should be stored undiluted at 4°C and protected from prolonged exposure to light. Do not freeze.

CD22 protein structure - 302506 shown in red.