351803

antibody from BioLegend

Targeting: IGF1R CD221, IGFIR, IGFR, JTK13, MGC18216

Western blot (Recommended by provider)

Immunoprecipitation (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Flow cytometry (Data presented on provider website)

Blocking/Neutralizing (Recommended by provider)

Antibody Data

Product number

351803

Provider

BioLegend

Proper citation

BioLegend Cat#351803, RRID:AB_10933256

Product name

LEAF™ Purified anti-human CD221 (IGF-1R) [1H7/CD221]

Antibody type

Monoclonal

Antigen

IGF-1 receptor purified from human placentas

Description

CD221, also known as insulin-like growth factor 1 receptor (IGF1R), is a 135 kD transmembrane receptor. It is widely expressed on lymphoid and myeloid cells as well as non-haematopoietic cells. CD221 is a tyrosine kinase receptor and the ligands for CD221 are insulin-like growth factor 1 and 2 (IGF-1 and IGF-2), the polypeptide hormones similar in molecular structure to insulin. IGF-1/2 binding activates downstream PI3K and MAPK pathways and plays an important role in cell growth. Recent studies reveal its function of recruiting immune cells during tissue repair.

Reactivity

Human

Host

Mouse

Conjugate

Unconjugated

Isotype

IgG

Vial size

50 µg

Concentration

1 mg/ml

Storage

The antibody solution should be stored undiluted at 4°C. This LEAF™ solution contains no preservative; handle under aseptic conditions.