66035-1-Ig

antibody from Proteintech Group

Targeting: ANXA2 ANX2, ANX2L4, CAL1H, LIP2, LPC2D

Provider product page for 66035-1-Ig

Western blot

ELISA

Immunocytochemistry

Immunohistochemistry

Flow cytometry

Antibody data

Antibody Data
Antigen structure
References [27]
Comments [0]
Validations
Western blot [1]
Immunohistochemistry [2]

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Product number: 66035-1-Ig - Provider product page
Provider: Proteintech Group
Proper citation: Proteintech Cat#66035-1-Ig, RRID:AB_11045659
Product name: Annexin A2 antibody
Antibody type: Monoclonal
Description: KD/KO validated Annexin A2 antibody (Cat. #66035-1-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: FC, IF, IHC, WB,ELISA.
Reactivity: Human, Mouse, Rat
Host: Mouse
Conjugate: Unconjugated
Isotype: IgG
Antibody clone number: 1C1E12
Vial size: 20ul, 150ul

ANXA2 protein structure - 66035-1-Ig shown in red.

Submitted references Brain and neural cell type proteomics reveal extracellular matrix proteins enriched in progressive multiple sclerosis.

Wang H, Pollock NM, Miranzadeh Mahabadi H, Patel J, Moussa EW, Fernandes JP, Branton WG, Zhang N, Elliott C, Schmitt L, Power C, Julien O
Nature communications 2026 Jan 7;17(1):1368

Changes in Placentas of Pregnant Women Infected with COVID-19.

Kramar S, Nebesna Z, Yakymchuk Y, Boychuk A, Shevchuk O, Korda M, Vari SG
International journal of molecular sciences 2025 Sep 4;26(17)

Dysferlin Protein-Protein Interaction Pathways in the Organ of Corti and Spiral Ganglion Intersect with Alzheimer's Protein Pathways.

Drescher MJ, Drescher DG, Khan KM, Hatfield JS, Hemani D
International journal of molecular sciences 2025 Sep 30;26(19)

Annexin A2 Contributes to Release of Extracellular Vimentin in Response to Inflammation.

Yuan Z, Ostrowska-Podhorodecka Z, Cox T, Norouzi M, Wang Y, Robaszkiewicz K, Siatkowska M, Xia K, Ali A, Abovsky M, Jurisica I, Smith P, McCulloch CA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 May 15;39(9):e70621

A large-scale sORF screen identifies putative microproteins involved in cancer cell fitness.

Schlesinger D, Dirks C, Navarro C, Lafranchi L, Spinner A, Raja GL, Mun-Sum Tong G, Eirich J, Martinez TF, Elsässer SJ
iScience 2025 Mar 21;28(3):111884

Proteomic landscape of tunneling nanotubes reveals CD9 and CD81 tetraspanins as key regulators.

Notario Manzano R, Chaze T, Rubinstein E, Penard E, Matondo M, Zurzolo C, Brou C
eLife 2024 Sep 9;13

Effects of cadherin mediated contact normalization on oncogenic Src kinase mediated gene expression and protein phosphorylation.

Nicoletto RE, Holdcraft CJ, Yin AC, Retzbach EP, Sheehan SA, Greenspan AA, Laugier CM, Trama J, Zhao C, Zheng H, Goldberg GS
Scientific reports 2024 Oct 13;14(1):23942

Quiescent cancer cells induced by high-density cultivation reveals cholesterol-mediated survival and lung metastatic traits.

Liu X, Min Q, Cheng X, Zhang W, Wu Q, Chen X, Lv M, Liu S, Zhao H, Yang D, Tai Y, Lei X, Wang Y, Zhan Q
British journal of cancer 2024 Nov;131(10):1591-1604

Activation of astrocytes by ANXA2-derived extracellular vesicles from lung cancer cells affects aggressiveness, immunotherapy response and microenvironment of lung cancer.

He M, Xie G, Shen F, Li X
Heliyon 2024 Mar 30;10(6):e27729

Dissecting the MUC5AC/ANXA2 signaling axis: implications for brain metastasis in lung adenocarcinoma.

Chaudhary S, Siddiqui JA, Appadurai MI, Maurya SK, Murakonda SP, Blowers E, Swanson BJ, Nasser MW, Batra SK, Lakshmanan I, Ganti AK
Experimental & molecular medicine 2024 Jun;56(6):1450-1460

Identification and validation of the surface proteins FIBG, PDGF-β, and TGF-β on serum extracellular vesicles for non-invasive detection of colorectal cancer: experimental study.

Huang Z, Deng C, Ma C, He G, Tao J, Zhang L, Hu X, Mo Y, Qiu L, Zhang N, Luo C, Xing S, Xie J, Yin H
International journal of surgery (London, England) 2024 Aug 1;110(8):4672-4687

Nuclear autoantigenic sperm protein facilitates glioblastoma progression and radioresistance by regulating the ANXA2/STAT3 axis.

Qiu Y, Pei D, Wang M, Wang Q, Duan W, Wang L, Liu K, Guo Y, Luo L, Guo Z, Guan F, Wang Z, Xing A, Liu Z, Ma Z, Jiang G, Yan D, Liu X, Zhang Z, Wang W
CNS neuroscience & therapeutics 2024 Apr;30(4):e14709

Stress granules plug and stabilize damaged endolysosomal membranes.

Bussi C, Mangiarotti A, Vanhille-Campos C, Aylan B, Pellegrino E, Athanasiadi N, Fearns A, Rodgers A, Franzmann TM, Šarić A, Dimova R, Gutierrez MG
Nature 2023 Nov;623(7989):1062-1069

Inhibition of ANXA2 activity attenuates epileptic susceptibility and GluA1 phosphorylation.

Ma L, Wu Q, Yuan J, Wang Y, Zhang P, Liu Q, Tan D, Liang M, Chen Y
CNS neuroscience & therapeutics 2023 Nov;29(11):3644-3656

Selenomethionine promotes ANXA2 phosphorylation for proliferation and protein synthesis of myoblasts and skeletal muscle growth.

Zhang M, Li X, Cui X, Li R, Ma Z, Gao X
The Journal of nutritional biochemistry 2023 May;115:109277

Hypoxia-induced circADAMTS6 in a TDP43-dependent manner accelerates glioblastoma progression via ANXA2/ NF-κB pathway.

Zhao S, Li B, Zhao R, Pan Z, Zhang S, Qiu W, Guo Q, Qi Y, Gao Z, Fan Y, Xu H, Li M, Zhang J, Wang H, Xu J, Wang S, Wang Q, Qiu J, Deng L, Guo X, Zhang P, Xue H, Li G
Oncogene 2023 Jan;42(2):138-153

Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.

Lin H, Li W, Shen Z, Bei Y, Wei T, Yu Z, Dai Y, Dai H
Neuroscience letters 2023 Jan 1;792:136941

Analysis of Dysferlin Direct Interactions with Putative Repair Proteins Links Apoptotic Signaling to Ca(2+) Elevation via PDCD6 and FKBP8.

Drescher DG, Drescher MJ, Selvakumar D, Annam NP
International journal of molecular sciences 2023 Feb 28;24(5)

Chip-DSF: A rapid screening strategy for drug protein targets.

Cui Z, Chen P, Li C, Deng S, Yang H
Pharmacological research 2022 Aug;182:106346

Annexins A1 and A2 are recruited to larger lysosomal injuries independently of ESCRTs to promote repair.

Yim WW, Yamamoto H, Mizushima N
FEBS letters 2022 Apr;596(8):991-1003

Human epididymis protein 4 promotes P‑glycoprotein‑mediated chemoresistance in ovarian cancer cells through interactions with Annexin II.

Liu Q, Liu DW, Zheng MJ, Deng L, Wang HM, Jin S, Liu JJ, Hao YY, Zhu LC, Lin B
Molecular medicine reports 2021 Jul;24(1)

TRIM21-regulated Annexin A2 plasma membrane trafficking facilitates osteosarcoma cell differentiation through the TFEB-mediated autophagy.

Zhang HT, Zeng Q, Wu B, Lu J, Tong KL, Lin J, Liu QY, Xu L, Yang J, Liu X, Liu W, Zhang YF, Lian Q, Liu L, Gao X
Cell death & disease 2021 Jan 6;12(1):21

Chlorogenic acid inhibits the proliferation of human lung cancer A549 cell lines by targeting annexin A2 in vitro and in vivo.

Wang L, Du H, Chen P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2020 Nov;131:110673

Interaction of HE4 and ANXA2 exists in various malignant cells-HE4-ANXA2-MMP2 protein complex promotes cell migration.

Wang J, Deng L, Zhuang H, Liu J, Liu D, Li X, Jin S, Zhu L, Wang H, Lin B
Cancer cell international 2019;19:161

Role of Annexin A2 isoform 2 on the aggregative growth of dermal papillae cells.

Gu J, Ma Y, Yang L, Wang F, Lei C, Zhai J, Xia R
Bioscience reports 2018 Dec 21;38(6)

Expression and clinical significance of annexin A2 and human epididymis protein 4 in endometrial carcinoma.

Deng L, Gao Y, Li X, Cai M, Wang H, Zhuang H, Tan M, Liu S, Hao Y, Lin B
Journal of experimental & clinical cancer research : CR 2015 Sep 11;34(1):96

An iTRAQ based quantitative proteomic strategy to explore novel secreted proteins in metastatic hepatocellular carcinoma cell lines.

Yu Y, Pan X, Ding Y, Liu X, Tang H, Shen C, Shen H, Yang P
The Analyst 2013 Aug 21;138(16):4505-11

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Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: human brain tissue were subjected to SDS PAGE followed by western blot with 66035-1-Ig(ANXA2 antibody) at dilution of 1:1000
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: Immunohistochemical of paraffin-embedded human breast cancer using 66035-1-Ig(ANXA2 antibody) at dilution of 1:50 (under 10x lens)
Sample type: tissue

Supportive validation

Submitted by: Proteintech Group (provider)
Main image
Experimental details: The Annexin A2 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human Annexin A2. This antibody recognizes human antigen. The Annexin A2 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
Appendix: 66035-1-Ig.pdf

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