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- Product number
- 60203-2-Ig - Provider product page
- Provider
- Proteintech Group
- Proper citation
- Proteintech Cat#60203-2-Ig, RRID:AB_10912803
- Product name
- AKT antibody
- Antibody type
- Monoclonal
- Description
- KD/KO validated AKT antibody (Cat. #60203-2-Ig) is a mouse monoclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB, ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Mouse
- Conjugate
- Unconjugated
- Isotype
- IgG
- Antibody clone number
- 2C5D1
- Vial size
- 20ul, 150ul
Submitted references NRG1 Suppresses NLRP3 Inflammasome Activation and Endothelial-Mesenchymal Transition in Cerebral Ischemia-Reperfusion Injury: Association with the AKT/NF-κB Pathway.
Globulol from Alpinia oxyphylla Miq. Enhances the pharmacological effects of anti-PD-1 drugs in combination by reducing PD-L1 expression in hepatocellular carcinoma.
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Terminalia chebula Extract Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the Interleukin-17-Dependent Mitogen-Activated Protein Kinase/Nuclear Factor-Kappa B Signaling Pathways.
Yinhuo Decoction attenuates depression-like behaviors and promotes M2 microglia polarization by regulating PI3K/Akt/NF-κB signaling pathway in a murine model of menopausal depression.
A multi-omics approach to decipher the protective mechanism of Myristica fragrans against acute lung injury.
Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice.
Puerarin suppress adipogenesis and inflammation on orbital fibroblasts from patients with thyroid eye disease.
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Thrombin Generation Induced by Complement Component C1q Interaction With the Receptor for the Globular Head of C1q on Adventitial Fibroblasts and Vascular Smooth Muscle Cells.
JOSD2 alleviates hypertensive renal disease through deubiquitinating AKT in renal tubular epithelial cells.
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.
Cellular Effects and Regulated Protein Expression of MCF-7 Breast Cancer Cells Following Exposure to PAH Derivative 3-Hydroxybenz[a]anthracene.
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
UFMylation-dependent inhibition of AKT signaling by PHLDA3 in lung adenocarcinoma.
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Combined Multi-Omics Analysis Reveals the Potential Role of Methionine in Regulating the Proliferation, Differentiation, and Lipid Deposition of Yak Intramuscular Preadipocytes.
A monoclonal antibody W1 blocks mesothelin-mediated tumor progression.
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
Hedyotis diffusa and Scutellaria barbata enhance the anti-ovarian cancer effect of cisplatin through network pharmacology analysis and molecular docking technology.
CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance.
Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk.
Oral Rhizoma Coptis Alkaloids Nanoparticle for Treating Diabetes Through Regulating PI3K/Akt Pathways.
Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis.
MRPL15 as a Key Gene in the Malignant Proliferation of LUAD.
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.
Targeting NBL1/PI3K/AKT axis to enhance the chemosensitivity and radiosensitivity of esophageal squamous cell carcinoma.
Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease.
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Novel Roles of GDF15 in Alleviating Renal Fibrosis: Promoting Autophagy and Lysosome Biogenesis via Inhibition of the PI3K/Akt/mTOR Pathway.
Linoleic acid promotes osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates ovariectomy (OVX)-induced osteoporosis in mice through the PI3K/AKT pathway.
QiShenYiQi dripping pills ameliorate post-myocardial infarction cardiac fibrosis via modulation of the cAMP/Rap1 and PI3K/Akt signaling pathways.
Poria cocos Attenuates LPS/D-Galactosamine-Induced Acute Liver Failure in Rats: An Integrative Exploratory Study Combining Network Pharmacology and In Vivo Validation.
Transcriptome and m6A epitranscriptome profiling reveal CCL20 as a key mediator of inflammation in Staphylococcus aureus-induced bovine mastitis.
KIN17 facilitates the initiation and progression of renal tumor progression through the PI3K-AKT-mTOR pathway.
NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy.
Targeting fatty acid metabolism in hepatic macrophages mitigates acetaminophen-induced liver injury and promotes regeneration in mice.
Dysregulation of Rho-Associated Coiled-Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury.
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Knockdown of ALOX15 alleviates acute coronary syndrome via the FGFR2/PI3K/AKT signaling pathway.
DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.
Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.
Mechanistic study of the role of emodin in targeting and inhibiting the Rap1 signaling pathway to regulate epithelial-mesenchymal transition and reverse cisplatin resistance in hepatocellular carcinoma.
Claudin18.2 promote gastric cancer proliferation by activating MCM2/5.
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS.
Leveraging self-healing CASH gel for enhanced paracrine secretion of mesenchymal stem cells to boost endometrial regeneration.
Sildenafil suppresses osteoporosis-related bone marrow adiposity by inhibiting Adipogenic differentiation of mesenchymal stem cells.
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression.
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Panax notoginseng saponins protect the blood-brain barrier against oxidative stress by activating the Akap12-PI3K/AKT-AQP1 signaling axis.
Mettl3-Mediated m6A Methylation of Pdgfrb Regulates the Angiogenesis-Dependent Bone Formation.
Metformin hydrochloride regulates glycolysis and inhibits PEDV replication by inhibition of PI3K-AKT signaling pathway.
Structural characterization and hypoglycemic mechanisms of a Hericium coralloides heteropolysaccharide (HCP-2b) via gut microbiota modulation and PI3K/Akt signaling.
Inhibition of TRPC6 channel suppresses bladder cancer proliferation by disrupting store-operated calcium entry.
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway.
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation.
Unveiling the Therapeutic Potential of Banxia Xiexin Decoction in Alzheimer's Disease: Insights From Network Pharmacology and Experimental Validation.
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.
Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis.
Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus.
Extracellular vesicles-miR-205-5p inhibits lymphatic metastasis in pancreatic cancer through diffusely downregulating VEGFA.
Levocarnitine improves cardiac energy metabolic remodeling in myocarditis mice.
Dual function antibody targeting αvβ3 and PD-L1 provide a promising strategy for solid tumor therapy.
CRTC1 enhances PD-L1-mediated tumor immunosuppression in non-small cell lung cancer via the Notch1/Akt signaling pathway.
Integrative bioinformatics and experimental validation unveil CRISP3 as a hypoxia-, epithelial mesenchymal transition-, and immune-related prognostic biomarker and therapeutic target in breast cancer.
Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling.
Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511.
Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axis.
Ruminococcus bromii-generated acetate alleviated Clonorchis sinensis-induced liver fibrosis in mice.
Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells.
Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves' disease through integrated serum metabolomics and network pharmacology with molecular docking techniques.
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell.
Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming.
MiR-424-5p acts as an oncogene in Hep3B cells by activating the PI3K/AKT signaling pathway.
Role of SUV39H2 in shaping the malignant phenotype of triple-negative breast cancer.
RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3.
The m6A demethylase FTO suppresses glioma proliferation by regulating the EREG/PI3K/Akt signaling pathway.
The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury.
Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis.
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways.
Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway.
Ubiquitin-specific protease 7-mediated stabilization of discoidin domain receptor 1 drives progression of TP53-Mutant cancers.
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Study on the role of FN1 in chronic obstructive pulmonary disease.
Investigating the Mechanism of Yiqi Huoxue Jieyu Granules Against Ischemic Stroke Through Network Pharmacology, Molecular Docking and Experimental Verification.
IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function.
Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway.
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Human papillomavirus-related syntaxin 11 reprograms tumor-associated macrophages to induce breast cancer cell apoptosis via PI3K/AKT signaling.
Reprogramming Macrophage via an Antigen Phagocytosis-Presentation Nanoenhancer for Improved Cancer Immunotherapy.
Strontium-Loaded Chitosan/Wood Hydrogel with Anisotropic Cellular Architecture for Enhanced Critical Bone Regeneration.
Ursolic acid sensitizes bladder cancer to gemcitabine chemotherapy by concurrently targeting PI3K/AKT and JNK pathways.
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway.
METTL16 promotes progression of clear cell renal cell carcinoma via up-regulating N6-methyladenosine modification of KLK4 mRNA.
CXCL10 Involvement in Vestibular Migraine via the PI3K/AKT Signaling Pathway.
TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration.
Astragaloside IV delayed the epithelial-mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways.
Small nucleolar RNA host gene 1 (SNHG1) facilitates gemcitabine chemosensitivity in gallbladder cancer by regulating the miR-23b-3p/phosphatase and tensin homolog (PTEN) pathway.
Lipoxin A4 Regulates M2 Macrophage-Derived Exosomal miR-25-5p to Protect Cell Pyroptosis in Bronchopulmonary Dysplasia.
Single-Nucleus Transcriptomic Landscape of Neonatal Mice Hippocampus During Sevoflurane-Induced Neurotoxicity.
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway.
Autophagy-targeted intervention synergized with pegaspargase: an innovative therapeutic paradigm for pancreatic cancer.
Histone demethylase KDM9 activates the CCND1/AKT pathway to promote the malignant progression of gliomas through interaction with BRD2.
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.
Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1 antibody efficacy via immunometabolic remodeling in colorectal cancer.
Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury.
Exosomal lncRNA MIR210HG derived from hypoxic TAMs promotes the metastasis of triple negative breast cancer.
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway.
Calcitriol Modulates Hippocampal Axon Guidance Through Enhanced EfnA4-Mediated PI3K/AKT Signaling in an Autism Mouse Model.
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways.
Xiao-Chai-Hu granule alleviates influenza virus-induced pneumonia by regulating TLR4-PI3K-Akt/p38 MAPK-NF-κB pathways.
Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model.
Study on the molecular mechanism of UBA52 and BARD1 regulating hepatocellular carcinoma through the PI3 K/AKT signaling pathway.
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus.
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.
Cooperative blockade of FLT3 and ALK synergistically suppresses growth of osteosarcoma.
Preparation, characterization, and stability of selenium nanoparticles decorated with Mori Fructus polysaccharide and its protective effects in bisphenol A-induced Sertoli cells.
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione mediates the effect of ROS-enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer.
Targeting TTK Inhibits Tumorigenesis of T-Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway.
Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction.
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis.
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.
Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
Dichloroacetate protects against sulfur mustard-induced neurotoxicity via the PDK/PDH axis and Akt/Nrf2 pathway.
Insufficient expression of COL6A1 promotes the development of early-onset severe preeclampsia by inhibiting the APJ/AKT signaling pathway.
TSPAN31 Activates Fatty Acid Metabolism and PI3K/AKT Pathway to Promote Tumor Progression in Breast Cancer.
Carnosol mitigates Ang II-stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation.
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway.
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
IL-37 inhibited inflammation to improve gestational diabetes mellitus through the GSK3/NF-κB pathway.
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1.
Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from In Vitro and In Vivo Studies.
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes.
Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway.
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments.
Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling.
Guyuan Jiannao decoction improves neurovascular unit dysfunction by regulating PI3K/AKT/NF-κB signaling pathway in cerebral small vessel disease rats.
Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma.
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets.
Asiaticoside enhances the anti-tumor effect of anti-PDL1 by regulating T cell activity through increasing LCK activity.
The Tumor-Suppressive Role of miR-204-5p Through Targeting Ezrin in Breast Cancer: Experimental Evidence From Cell Lines and Clinical Samples.
LACTB promotes cell differentiation and inhibits cell proliferation in colorectal cancer.
A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma.
Moesin silencing enhances the radiosensitivity of glioblastoma by inhibiting DNA damage repair via CD44/AKT1 signaling pathway.
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR.
Schisandrin A ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis.
Activated mTORC1 signaling pathway aggravates cisplatin induced oxidative damage by inhibiting autophagy in mouse cochlear hair cells.
In-Depth Examination of TPBG as a New Predictive Indicator for Gastric Cancer.
IL-17A's role in exacerbating radiation-induced lung injury: Autophagy impairment via the PP2A-mTOR pathway.
Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer's disease via the PI3K/Akt pathway.
Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease: a network pharmacology and experimental approach.
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.
Homoharringtonine Added to Venetoclax and Azacitidine Improves Outcome and Mitigates Genetic Impact in Relapsed/Refractory AML: A Multicenter Cohort Study.
HSF1 and CPSF1 affect milk fat and protein synthesis by regulating the AKT/mTOR signaling pathway.
MYBL2 promotes proliferation of clear cell renal cell carcinoma by regulating TOP2A and activating AKT/mTOR signaling pathway.
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Integrative multi-omics and network pharmacology reveal the mechanisms of Fangji Huangqi Decoction in treating IgA nephropathy.
Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K/AKT signaling pathway.
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation.
GLP-1/GIP dual agonist tirzepatide normalizes diabetic nephropathy via PI3K/AKT mediated suppression of oxidative stress.
Downregulation of the PI3K/AKT/mTOR/MMP-13 pathway for promoting interface healing via lubricating microspheres.
The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity.
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression.
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells.
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway.
SHCBP1 promotes cisplatin resistance of ovarian cancer through AKT/mTOR/Autophagy pathway.
Network pharmacology and molecular docking reveal the mechanism of action of Bergapten against non‑small cell lung cancer.
α-arbutin prevents UVA-induced skin photodamage via alleviating DNA damage and collagen degradation in NIH-3T3 cells.
Non-starch polysaccharides from Castanea mollissima Bl. ameliorate metabolic syndrome by remodeling barrier function, microbial community, and metabolites in high-fat-diet/streptozotocin-induced diabetic mice.
Cis-Regulation of an m(6)A Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.
Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis.
Orally Administrated Precision Nanomedicine for Restoring the Intestinal Barrier and Alleviating Inflammation in Treatment of Inflammatory Bowel Disease.
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Cordycepin ameliorates spaceflight-induced osteoporosis by preventing BMSCs oxidative stress and senescence via interacting with PI3K p110α and regulating PI3K/Akt/FOXO3 signalling.
MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells.
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Tooth Loss-Induced Gut Dysbiosis Promotes Neuroinflammation via L-Asparagine-Mediated Neuronal Toxicity.
KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers.
Network pharmacology combined with experiments to explore the molecular mechanism of Jiawei Erzhi pill protects against atherosclerosis by inhibiting ferroptosis.
The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis.
HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells.
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.
Inhibition of ALOX5-dependent ferroptosis by 6-C-methylquercetin: a potential therapeutic approach for alleviating rheumatoid arthritis.
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Epigallocatechin-3-Gallate Attenuates Benign Prostatic Hyperplasia Development via Regulating Firmicutes to Inhibit Gastric Secretion of Insulin-Like Growth Factor-1.
A natural flavagline derivative A2073 inhibits the proliferation of erythroleukemia cells by targeting the MAPK, PI3K, NF-κB, and cell cycle pathways.
Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer-related gene in pancreatic cancer.
QSOX2-Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c-Myc Feedback Loop in Esophageal Squamous Cell Carcinoma.
p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes.
Tumor-derived exosomal tsRNA 3'tiRNA-AlaCGC in promoting fibroblast senescence and Galectin-9 secretion to induce immune tolerance in lung adenocarcinoma.
Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression.
Single-cell transcriptome analysis identifies MIF as a novel tumor-associated neutrophil marker for pancreatic ductal adenocarcinoma.
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
Activation of transient receptor potential vanilloid 4 impairs long-term depression in nucleus accumbens and induces depressive-like behavior.
Hua Yu Xiao Zheng decoction induces ectopic endometrial stromal cell senescence via inhibiting the PI3K/AKT signaling.
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes.
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.
Proteomic Analysis of Human Follicular Fluid-Derived Exosomes Reveals That Insufficient Folliculogenesis in Aging Women is Associated With Infertility.
p16(INK4a) Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.
Comparison of the effects between catalase and superoxide dismutase on regulating macrophage inflammatory response and protecting osteogenic function of periodontal ligament cells.
Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway.
Comprehensive analysis illustrating the role of HOXB8 in head and neck squamous cell carcinoma: evidence from multi-omics analysis and experiments validation.
Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32.
HNF4α-Mediated LINC02560 Promotes Papillary Thyroid Carcinoma Progression by Targeting the miR-505-5p/PDE4C Axis.
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Integrating metabolomics and network pharmacology to study the mechanism of Er-Xian decoction in improving intervertebral disc degeneration.
Trelagliptin Ameliorates Memory Decline in Diabetic Rats through the AMPK/AKT/GSK-3β Pathway in the Cerebral Cortex.
Role of Quercetin in Modulating Inflammation and Epigenetic Regulation of Staphylococcus aureus-Induced Bovine Mastitis.
Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis.
The Mechanism of Action and Experimental Verification of Narenmandula in the Treatment of Postmenopausal Osteoporosis.
Network Analysis and Basic Experiments on the Inhibition of Renal Cancer Proliferation and Migration by Alpinetin through PI3K/AKT/ mTOR Pathway.
Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
Electroacupuncture on GB acupoints improves osteoporosis via the estradiol-PI3K-Akt signaling pathway.
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior.
Cold Exposure Alleviates T2DM Through Plasma-Derived Extracellular Vesicles.
Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis.
Unveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora.
Ligustrazine alleviates spinal cord injury-induced neuropathic pain by inhibiting the TLR4/NF-κB signaling pathway.
KRT80 Promotes Lung Adenocarcinoma Progression and Serves as a Substrate for VCP.
Integrated UPLC-ESI-MS/MS, network pharmacology, and transcriptomics to reveal the material basis and mechanism of Schisandra chinensis Fruit Mixture against diabetic nephropathy.
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
KIF11 promotes vascular smooth muscle cell proliferation by regulating cell cycle progression and accelerates neointimal formation after arterial injury in mice.
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment.
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy.
Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier.
Acromegalic Rat Model Presented Cognitive Impairments and Tau Hyperphosphorylation in the Hippocampus.
ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells.
Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway.
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Anti‑epileptic mechanism of isopimaric acid from Platycladi cacumen based on network pharmacology, molecular docking and biological validation.
Nesfatin-1 mitigates calcific aortic valve disease via suppressing ferroptosis mediated by GSH/GPX4 and ZIP8/SOD2 axes.
Panax notoginseng saponins dually modulates autophagy in gastric precancerous lesions complicated with myocardial ischemia-reperfusion injury model through the PI3K/AKT/mTOR pathway.
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways.
BUB1 induces AKT/mTOR pathway activity to promote EMT induction in human small cell lung cancer.
A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4.
Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice.
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.
Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway.
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Promoter hypermethylation-induced downregulation of ITGA7 promotes colorectal cancer proliferation and migration by activating the PI3K/AKT/NF-κB pathway.
The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation.
Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway.
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
ROCK2 increases drug resistance in acute myeloid leukemia via metabolic reprogramming and MAPK/PI3K/AKT signaling.
Unveiling an anoikis-related risk model and the role of RAD9A in colon cancer.
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment.
Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway.
Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma.
Silica nanoparticles cause ovarian dysfunction and fertility decrease in mice via oxidative stress-activated autophagy and apoptosis.
Regulation of cervical cancer via G15-mediated inhibition of G protein-coupled estrogen receptor.
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota.
Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa-induced dyskinesia in a mouse model of Parkinson's disease.
Schizophyllum commune fruiting body polysaccharides inhibit glioma by mediating ARHI regulation of PI3K/AKT signalling pathway.
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18.
Protective effect of folic acid on MNNG-induced proliferation of esophageal epithelial cells via the PI3K/AKT/mTOR signaling pathway.
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation.
Succinic Acid Improves the Metabolism of High-Fat Diet-Induced Mice and Promotes White Adipose Browning.
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Mechanism of cold exposure delaying wound healing in mice.
PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A.
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway.
Folic Acid Attenuates N-Methyl-N'-Nitro-N-NitrosoguanidineInduced Gastric Mucosal Injury in Rats.
Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways.
2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways.
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.
CNPY2 governs PDGF‑BB‑treated vascular smooth muscle cell proliferation, migration and phenotypic transformation via the Akt/mTOR/GSK‑3β signaling pathway.
HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway.
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Untargeted metabolomic reveals the changes in muscle metabolites of mice during exercise recovery and the mechanisms of whey protein and whey protein hydrolysate in promoting muscle repair.
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing.
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.
BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells.
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway.
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology.
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking.
Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice.
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury.
Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway.
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.
The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways.
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway.
Kallistatin Improves High-Fat-Induced Insulin Resistance via Epididymal Adipose Tissue-Derived Exosomes.
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
RNA sequencing screening and gene function analysis uncover G protein-coupled receptor 183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells.
Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer.
FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.
NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.
Chemotherapy-induced high expression of IL23A enhances efficacy of anti-PD-1 therapy in TNBC by co-activating the PI3K-AKT signaling pathway of CTLs.
CSTF3 contributes to platinum resistance in ovarian cancer through alternative polyadenylation of lncRNA NEAT1 and generating the short isoform NEAT1_1.
Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis.
Gold Nanoparticle Delivery of Glut1 SiRNA Facilitates Glucose Starvation Therapy in Lung Cancer.
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism.
Identification of bioactive ingredients and potential mechanisms of flowers of Hosta Plantaginea in treating pneumonia based on network pharmacology and experimental validation.
Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.
Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling.
SPP1 could be an immunological and prognostic biomarker: From pan-cancer comprehensive analysis to osteosarcoma validation.
Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-α/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia.
Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
FAM134B deletion exacerbates apoptosis and epithelial-to-mesenchymal transition in rat lungs exposed to hyperoxia.
Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma.
PRAME promotes proliferation of multiple myeloma cells through CTMP/Akt/p21/CCND3 axis by ubiquitinating CTMP and p21.
LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway.
FOLR1-stabilized β-catenin promotes laryngeal carcinoma progression through EGFR/AKT/GSK-3β pathway.
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer.
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
AKR1B10 inhibits the proliferation and metastasis of hepatocellular carcinoma cells by regulating the PI3K/AKT pathway.
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
TESC acts as a prognostic factor and promotes epithelial-mesenchymal transition progression in esophageal squamous carcinoma.
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway.
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.
SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway.
FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Manipulating HGF signaling reshapes the cirrhotic liver niche and fills a therapeutic gap in regeneration mediated by transplanted stem cells.
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
PXMP4 promotes gastric cancer cell epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.
DPPA2/4 Promote the Pluripotency and Proliferation of Bovine Extended Pluripotent Stem Cells by Upregulating the PI3K/AKT/GSK3β/β-Catenin Signaling Pathway.
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells.
Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease.
Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments.
MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation.
Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.
In silico and in vivo verification of the mechanism of formononetin in treating hepatocellular carcinoma.
MiR-19b-3p inhibits cell viability and proliferation and promotes apoptosis by targeting IGF1 in KGN cells.
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
Polyphyllin II inhibits breast cancer cell proliferation via the PI3K/Akt signaling pathway.
Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis.
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Quercetin inhibits malignant progression of high metastatic advanced colon cancer in hypoxia via suppressing ROS and PI3K/AKT pathway.
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Rehmannioside A promotes the osteoblastic differentiation of MC3T3-E1 cells via the PI3K/AKT signaling pathway and inhibits glucocorticoid-induced bone loss in vivo.
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Tryptophan supplements in high-carbohydrate diets by improving insulin response and glucose transport through PI3K-AKT-GLUT2 pathways in blunt snout bream (Megalobrama amblycephala).
MEK inhibitor trametinib combined with PI3K/mTOR inhibitor BEZ-235 as an effective strategy against NSCLC through impairment of glucose metabolism.
ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/PI3K/AKT pathway in ovarian cancer.
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
The dual role of calnexin on malignant progression and tumor microenvironment in glioma.
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.
Osteoblast-derived exosomal miR-140-3p targets ACER2 and increases the progression of prostate cancer via the AKT/mTOR pathway-mediated inhibition of autophagy.
The vitamin D receptor is essential for the replication of pseudorabies virus.
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.
Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposure.
IL-33-dependent NF-κB activation inhibits apoptosis and drives chemoresistance in acute myeloid leukemia.
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.
Tanshinone I improves TNBC chemosensitivity by suppressing late-phase autophagy through AKT/p38 MAPK signaling pathway.
Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension.
GGT5 as a promising prognostic biomarker and its effects on tumor cell progression in gastric cancer.
Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway.
MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma.
Identification of epithelial-related artificial neural network prognostic models for the prediction of bladder cancer prognosis through comprehensive analysis of single-cell and bulk RNA sequencing.
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma.
Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.
Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway.
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer.
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K/NRF2/system Xc-/GPX4 axis in neonatal rats.
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.
The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation : The involved molecular and immunological mechanisms.
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes.
MATN2 overexpression suppresses tumor growth in ovarian cancer via PTEN/PI3K/AKT pathway.
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
Exploring the Potential Mechanisms of Guanxinshutong Capsules in Treating Pathological Cardiac Hypertrophy based on Network Pharmacology, Computer-Aided Drug Design, and Animal Experiments.
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis-angiogenesis coupling by modulating Cer/PP2A/Akt pathway.
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells.
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Inhibition of Ehrlich ascites carcinoma growth by melatonin: Studies with micro-CT.
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
Upregulation of LRRC8A by m(5)C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer.
Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch.
SHCBP1 Promotes the Proliferation of Breast Cancer Cells by Inhibiting CXCL2.
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats.
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation.
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke.
Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate.
Ze-Qi decoction inhibits non-small cell lung cancer growth and metastasis by modulating the PI3K/Akt/p53 signaling pathway.
Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.
DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.
Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10.
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Irreversible repolarization of tumour-associated macrophages by low-Pi stress inhibits the progression of hepatocellular carcinoma.
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Liquiritigenin regulates insulin sensitivity and ameliorates inflammatory responses in the nonalcoholic fatty liver by activation PI3K/AKT pathway.
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Identification of Potential Mechanisms of Rk1 Combination with Rg5 in the Treatment of Type II Diabetes Mellitus by Integrating Network Pharmacology and Experimental Validation.
Jin-Gui-Shen-Qi Wan ameliorates diabetic retinopathy by inhibiting apoptosis of retinal ganglion cells through the Akt/HIF-1α pathway.
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Meroterpenoids from Daphne genkwa shows promising in vitro antitumor activity via inhibiting PI3K/Akt/mTOR signaling pathway in A549 cells.
MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer.
Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways.
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner.
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.
Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity.
Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis.
Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer.
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
microRNA-17 is a tumor suppressor in oral squamous cell carcinoma and is repressed by LSD1.
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway.
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy.
Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment.
Visceral adipose tissue-directed human kallistatin gene therapy improves adipose tissue remodeling and metabolic health in obese mice.
Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis.
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
HDAC inhibitor chidamide overcomes drug resistance in chronic myeloid leukemia with the T315i mutation through the Akt-autophagy pathway.
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
LHPP suppresses proliferation, migration, and invasion in hepatocellular carcinoma and pancreatic cancer by inhibiting EGFR signaling pathway.
MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway.
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling.
Lysophosphatidic acid is associated with oocyte maturation by enhancing autophagy via PI3K-AKT-mTOR signaling pathway in granulosa cells.
AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.
ATAXIA TELANGIECTASIA MUTATED PROTECTS AGAINST LIPOPOLYSACCARIDE-INDUCED BLOOD-BRAIN BARRIER DISRUPTION BY REGULATING ATK/DRP1-MEDIATED MITOCHONDRIAL HOMEOSTASIS.
Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway.
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3.
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus.
Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of Schisandra Chinensis Mixture on diabetic nephropathy.
PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition.
Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway.
Molecular Targets and Mechanisms of Casein-Derived Tripeptides Ile-Pro-Pro and Val-Pro-Pro on Hepatic Glucose Metabolism.
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Heterodimerization of cholecystokinin 1 and cholecystokinin 2 receptors in gallbladder cancer: a new mechanism for carcinogenesis.
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Tumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response.
MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3.
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism.
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway.
Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus.
Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction.
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice.
Xiao-Chai-Hu Decoction Ameliorates Poly (I:C)-Induced Viral Pneumonia through Inhibiting Inflammatory Response and Modulating Serum Metabolism.
TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
Mechanism of Abelmoschus manihot L. in the Treatment of Contrast-Induced Nephropathy on the Basis of Network Pharmacology Analysis.
Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells.
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Taurine Ameliorates Apoptosis via AKT Pathway in the Kidney of Diabetic Rats.
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Puffball spores improve wound healing in a diabetic rat model.
Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking.
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis.
Neuregulin-1β increases glucose uptake and promotes GLUT4 translocation in palmitate-treated C2C12 myotubes by activating PI3K/AKT signaling pathway.
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Interleukin 33-mediated inhibition of A-type K(+) channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice.
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Sodium butyrate attenuates bovine mammary epithelial cell injury by inhibiting the formation of neutrophil extracellular traps.
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway.
CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.
Exploring Active Ingredients, Beneficial Effects, and Potential Mechanism of Allium tenuissimum L. Flower for Treating T2DM Mice Based on Network Pharmacology and Gut Microbiota.
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.
MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma.
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells.
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1.
Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Exploring the Effective Components and Mechanism of Action of Japanese Ardisia in the Treatment of Autoimmune Hepatitis Based on Network Pharmacology and Experimental Verification.
Taurine attenuates neuronal ferroptosis by regulating GABA(B)/AKT/GSK3β/β-catenin pathway after subarachnoid hemorrhage.
Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.
Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Vitamin D3 promotes autophagy in THP-1 cells infected with Mycobacterium tuberculosis.
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.
COL11A1-Driven Epithelial-Mesenchymal Transition and Stemness of Pancreatic Cancer Cells Induce Cell Migration and Invasion by Modulating the AKT/GSK-3β/Snail Pathway.
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway.
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells.
The anti-fatigue activity of corn peptides and their effect on gut bacteria.
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.
N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Chronic vitamin D(3) supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling.
METTL3-Mediated m(6)A Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling.
PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40.
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
CENPO regulated proliferation and apoptosis of colorectal cancer in a p53-dependent manner.
Mesenchyme homeobox 2 has a cancer-inhibiting function in breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways.
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway.
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity.
CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27(kip1) Axis.
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells.
The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer.
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma via PI3K/AKT Signaling Pathway.
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway.
Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis.
Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway.
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis.
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma.
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis.
Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification.
FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK.
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling.
The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Activation of Wnt/β-catenin signaling restores insulin sensitivity in insulin resistant neurons through transcriptional regulation of IRS-1.
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis.
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.
Functions of Forkhead Box O on Glucose Metabolism in Abalone Haliotis discus hannai and Its Responses to High Levels of Dietary Lipid.
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway.
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model.
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling.
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice.
Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation.
High PD‑L1 expression drives glycolysis via an Akt/mTOR/HIF‑1α axis in acute myeloid leukemia.
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling.
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells.
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
BML-111 inhibits EMT, migration and metastasis of TAMs-stimulated triple-negative breast cancer cells via ILK pathway.
Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities.
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy.
Nogo-B Receptor Directs Mitochondria-Associated Membranes to Regulate Vascular Smooth Muscle Cell Proliferation.
ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways.
Allogeneic adipose-derived stem cells suppress mTORC1 pathway in a murine model of systemic lupus erythematosus.
Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression.
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Chiral ruthenium(ii) complex as potent radiosensitizer of (125)I through DNA-damage-mediated apoptosis.
Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties.
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Apigenin ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1.
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Angiopoietin-like protein 2 facilitates non-small cell lung cancer progression by promoting the polarization of M2 tumor-associated macrophages.
Anti-tumor effect of evodiamine by inducing Akt-mediated apoptosis in hepatocellular carcinoma.
Metformin reduces glycometabolism of papillary thyroid carcinoma in vitro and in vivo.
CALCB splice region pathogenic variants leading to plasma cell neurotropic enrichment in type 1 autoimmune pancreatitis.
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
Quercetin prevents hepatic fibrosis by inhibiting hepatic stellate cell activation and reducing autophagy via the TGF-β1/Smads and PI3K/Akt pathways.
Enho Mutations Causing Low Adropin: A Possible Pathomechanism of MPO-ANCA Associated Lung Injury.
Cai Y, Wang Y, Wang D, Chen H, Zhu K, Cai X, Sun J
Journal of inflammation research 2026;19:584926
Journal of inflammation research 2026;19:584926
Globulol from Alpinia oxyphylla Miq. Enhances the pharmacological effects of anti-PD-1 drugs in combination by reducing PD-L1 expression in hepatocellular carcinoma.
Wang Z, Zhong Y, Hu J, Xie P, Zhao Y, Jiang C, Lu L, Zhou M, Xu J
Frontiers in pharmacology 2026;17:1728692
Frontiers in pharmacology 2026;17:1728692
Stem cell therapy targets THBS1 to reverse endometrial fibrosis.
Yu X, Shi L, Qu M, Zhang Y, Zhang Y, Xu X, Liu L, Wang H, Wang H
Frontiers in cell and developmental biology 2026;14:1766915
Frontiers in cell and developmental biology 2026;14:1766915
Terminalia chebula Extract Alleviates Lipopolysaccharide-Induced Acute Lung Injury by Modulating the Interleukin-17-Dependent Mitogen-Activated Protein Kinase/Nuclear Factor-Kappa B Signaling Pathways.
Li H, Bao S, Bai L, Li Z, Wang Q, Narenhu N, Xiao X, Bao L, Bai T
Phytotherapy research : PTR 2026 May;40(5):2965-2985
Phytotherapy research : PTR 2026 May;40(5):2965-2985
Yinhuo Decoction attenuates depression-like behaviors and promotes M2 microglia polarization by regulating PI3K/Akt/NF-κB signaling pathway in a murine model of menopausal depression.
Zhang Y, Lei X, Xue A, Zhao D, Ai H, Zhou Y, Wang W, Zhang N, Geng F, Xu H
Journal of ethnopharmacology 2026 May 23;363:121365
Journal of ethnopharmacology 2026 May 23;363:121365
A multi-omics approach to decipher the protective mechanism of Myristica fragrans against acute lung injury.
Wang QQ, Li H, Li L, Yang S, Li Z
Journal of ethnopharmacology 2026 May 10;362:121363
Journal of ethnopharmacology 2026 May 10;362:121363
Exercise preconditioning prevents immobilization-induced skeletal muscle atrophy by activating Prmt1-p38/ATF2-Sesn1 signaling axis in C57BL/6J mice.
Yang X, Zou Y, Wang H, Niu Y, Fu L
Sports medicine and health science 2026 Mar;8(2):197-209
Sports medicine and health science 2026 Mar;8(2):197-209
Puerarin suppress adipogenesis and inflammation on orbital fibroblasts from patients with thyroid eye disease.
Ma L, Hou Z, Liu C, Jiang X, Zhang J, Liu H, Li D
Journal of endocrinological investigation 2026 Mar;49(3):547-559
Journal of endocrinological investigation 2026 Mar;49(3):547-559
Baicalin Restores the Hypoglycemic Effect of Metformin by Regulating the Microbial Imidazole Propionate and Short-Chain Fatty Acids.
Wang A, Miao Z, Huang B, Zeng J, Yuan M, Yan D
Phytotherapy research : PTR 2026 Mar;40(3):1060-1073
Phytotherapy research : PTR 2026 Mar;40(3):1060-1073
The sphingolipid metabolite sphingosine protects against hypertension by targeting metabolic-inflammatory crosstalk via the NLRP3 inflammasome.
Li W, Zhou D, Ji Y, Yang M, Yang Y, Dao M, He X, Jin X
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
International journal of cardiology. Cardiovascular risk and prevention 2026 Mar;28:200562
Vitexin targets USP49-GRPR deubiquitination axis in medullary thyroid carcinoma therapy.
Xia Q, Dong S, Xu W, Lai Q, Song H, Zhang W
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168128
Biochimica et biophysica acta. Molecular basis of disease 2026 Mar;1872(3):168128
A novel proteolysis-targeting chimera strategy targeting multiple immune checkpoints containing ITIMs enhances antitumor immunity.
Qiu YY, Wang ZW, He L, Shi GG, Li ZZ, Ma SX, Yu D, Du HC, Xie F, Zhang C, Zhang YQ, Li M, Li WN
Journal of pharmaceutical analysis 2026 Mar;16(3):101511
Journal of pharmaceutical analysis 2026 Mar;16(3):101511
Thrombin Generation Induced by Complement Component C1q Interaction With the Receptor for the Globular Head of C1q on Adventitial Fibroblasts and Vascular Smooth Muscle Cells.
Freda CT, Yin W, Ghebrehiwet B, Rubenstein DA
Immunity, inflammation and disease 2026 Mar;14(3):e70374
Immunity, inflammation and disease 2026 Mar;14(3):e70374
JOSD2 alleviates hypertensive renal disease through deubiquitinating AKT in renal tubular epithelial cells.
Fan S, Zhao Y, Li L, Zhao Q, Fang Z, Xu D, Shao J, Zhao Y, Liang G, He X, Zhu H, Wang Y
Cellular signalling 2026 Mar;139:112330
Cellular signalling 2026 Mar;139:112330
TRIM27-controlled endothelium-derived exosomes play a central role in podocyte injury in diabetic kidney disease.
Tian Y, Liu Y, Feng X, Wu L, Song W, Zhao T, Liu J, Miao X, Ma H, Jia B, Kang L, Liu Q, Zhang W, Guo H, Yang L, Xu J, Liu S
Cell death discovery 2026 Mar 7;12(1)
Cell death discovery 2026 Mar 7;12(1)
Cellular Effects and Regulated Protein Expression of MCF-7 Breast Cancer Cells Following Exposure to PAH Derivative 3-Hydroxybenz[a]anthracene.
Kang X, Song W, Li X, Yang Y, Wu X
Toxics 2026 Mar 4;14(3)
Toxics 2026 Mar 4;14(3)
Stigmasterol upregulates Akt/mTOR/p70S6K signaling through SYVN1 to alleviate osteoporosis in ovariectomized rats.
Zhu F, Li W, Cao Y, Dai B, Wu H, Zhu Y, Liu H
European journal of nutrition 2026 Mar 26;65(3)
European journal of nutrition 2026 Mar 26;65(3)
UFMylation-dependent inhibition of AKT signaling by PHLDA3 in lung adenocarcinoma.
Ma X, Wan R, Yang X, Tang J, Wen Y, Huang L, Li X, Song Y, Zhou Y, Wang SH, Liu T
Cell reports 2026 Mar 25;45(4):117154
Cell reports 2026 Mar 25;45(4):117154
Hydrogen sulfide ameliorates oxalate crystal-related renal injury via inhibiting the activation of NOD-like receptor thermal protein domain associated protein 3 inflammasome in mice.
Shi Y, Chen L, Li M, Wang J, Yin P, Zhou X, Cong Q, Song K
Urolithiasis 2026 Mar 24;54(1)
Urolithiasis 2026 Mar 24;54(1)
Combined Multi-Omics Analysis Reveals the Potential Role of Methionine in Regulating the Proliferation, Differentiation, and Lipid Deposition of Yak Intramuscular Preadipocytes.
Wu X, Li J, Peng T, Fu J, Zhong J, Shi H, Wang H
Animals : an open access journal from MDPI 2026 Mar 2;16(5)
Animals : an open access journal from MDPI 2026 Mar 2;16(5)
A monoclonal antibody W1 blocks mesothelin-mediated tumor progression.
Wang Q, Cao G, Li M, Gong R
Molecular therapy. Oncology 2026 Mar 19;34(1):201094
Molecular therapy. Oncology 2026 Mar 19;34(1):201094
METTL3 stabilizes FASN mRNA by mediating m(6)A modification to promote malignant progression of diffuse large B-cell lymphoma.
Song X, Zhong Y, Yu N, Zou W, Li W, Lv Q, Luo Q, Zhong X
Cell & bioscience 2026 Mar 18;16(1)
Cell & bioscience 2026 Mar 18;16(1)
Hedyotis diffusa and Scutellaria barbata enhance the anti-ovarian cancer effect of cisplatin through network pharmacology analysis and molecular docking technology.
Bi R, Chen F, Fu Y, Guo C, Li W
Scientific reports 2026 Mar 17;16(1)
Scientific reports 2026 Mar 17;16(1)
CD93-targeted resveratrol-loaded PLGA nanoparticles remodel CD8⁺ T cell metabolism through AIF-mediated oxidative phosphorylation to overcome lung cancer immunotherapy resistance.
Jiang Z, Li Y
Journal of nanobiotechnology 2026 Mar 14;24(1)
Journal of nanobiotechnology 2026 Mar 14;24(1)
Mapping Genetic Regulation of Transcription to Identify Functional Variants and Genes Associated with Pancreatic Cancer Risk.
Wang X, Geng H, Yao Z, Jiang Y, Chen C, Lu Z, Tian S, Zhang M, Liu R, Feng C, Li B, Miao X, Tian J, Zhang S, Zhu Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 13;:e17184
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2026 Mar 13;:e17184
Oral Rhizoma Coptis Alkaloids Nanoparticle for Treating Diabetes Through Regulating PI3K/Akt Pathways.
Liu Y, Zhu M, Su Q, Liu M, Zhao Z, Ma P
Pharmaceutics 2026 Mar 11;18(3)
Pharmaceutics 2026 Mar 11;18(3)
Endothelial Nitric Oxide Synthase Restores Diabetic Dentin Regeneration via AKT/Endothelial Nitric Oxide Synthase Axis.
Feng X, Hu L, Zhang C, Lei W, Zhou B, Xia D, Shan Z, Jin L
International dental journal 2026 Jun;76(3):109511
International dental journal 2026 Jun;76(3):109511
MRPL15 as a Key Gene in the Malignant Proliferation of LUAD.
Wang Z, Qian Y, Lai X, Cui W, Luo J, Zeng W, He W, Liao M
Biochemical genetics 2026 Jun;64(3):3647-3662
Biochemical genetics 2026 Jun;64(3):3647-3662
Astragaloside IV alleviates post-traumatic cytotoxic edema via inhibition of AQP4 expression and subcellular localization.
Shen W, Jiang C, Liu X, Wang D, Li G, Hui Y, Ding Y, Li C, Shao B, Hou B
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jun;155:158096
Targeting NBL1/PI3K/AKT axis to enhance the chemosensitivity and radiosensitivity of esophageal squamous cell carcinoma.
Wang B, Zeng R, Lei L, Yang Z, Feng B
International immunopharmacology 2026 Jul 1;180:116665
International immunopharmacology 2026 Jul 1;180:116665
Allosteric activation of a cell-type-specific GPR120 inhibits amyloid pathology of Alzheimer's disease.
He A, Wang Y, Shen Y, Dong Z, Luo L, Ge X, Liu X, Mao Y, Zhang T, Li X, Li H, Jing W, Zhu LQ, Zhang Q, Lu Y
Nature aging 2026 Jan;6(1):181-199
Nature aging 2026 Jan;6(1):181-199
Nobiletin's role in idiopathic pulmonary fibrosis via the PI3K/AKT/MDM2/p53 signaling pathway.
Li T, Wang J, Bai L, Zhao Q, Zhu D, Xu Y, Wang Y, Wang Z, Feng F, Zhou X
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
Naunyn-Schmiedeberg's archives of pharmacology 2026 Jan;399(1):225-242
A bioactive protein from Dioscorea polystachya residue alleviates hydrocortisone-induced erectile dysfunction in rats via TXNIP/NLRP3 pathway inhibition.
Yu S, Zhang Y, Xi J, Feng J, Xie T, Pan D, Zhao D, Ren J, Dong Z, Liu M, Wang S
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
International journal of biological macromolecules 2026 Jan;335(Pt 1):149351
Novel Roles of GDF15 in Alleviating Renal Fibrosis: Promoting Autophagy and Lysosome Biogenesis via Inhibition of the PI3K/Akt/mTOR Pathway.
Li Y, Gu J, Tao D, Wu H, Yang C, Shi Y, Huang C, Luo B, Zhang J
Journal of cellular and molecular medicine 2026 Jan;30(1):e70951
Journal of cellular and molecular medicine 2026 Jan;30(1):e70951
Linoleic acid promotes osteogenic differentiation of bone marrow mesenchymal stem cells and ameliorates ovariectomy (OVX)-induced osteoporosis in mice through the PI3K/AKT pathway.
Liao H, Luo X, Jiang L
The international journal of biochemistry & cell biology 2026 Jan;190:106878
The international journal of biochemistry & cell biology 2026 Jan;190:106878
QiShenYiQi dripping pills ameliorate post-myocardial infarction cardiac fibrosis via modulation of the cAMP/Rap1 and PI3K/Akt signaling pathways.
Liu Z, Chen S, Fu H, Li K, Liu H, Qin L, Wang L, Jin J, Yin L, Chen J
Fitoterapia 2026 Jan;188:107020
Fitoterapia 2026 Jan;188:107020
Poria cocos Attenuates LPS/D-Galactosamine-Induced Acute Liver Failure in Rats: An Integrative Exploratory Study Combining Network Pharmacology and In Vivo Validation.
Wen P, Jian X, Ren X, Zhao S, Yang Y, Ge H, Li L, Wang H, Li M, Wang L
International journal of molecular sciences 2026 Jan 30;27(3)
International journal of molecular sciences 2026 Jan 30;27(3)
Transcriptome and m6A epitranscriptome profiling reveal CCL20 as a key mediator of inflammation in Staphylococcus aureus-induced bovine mastitis.
Shi Z, Wang Y, Deng T, Shokrollahi B, Wang W, Wang W, Abdel-Shafy H
BMC microbiology 2026 Jan 24;26(1):133
BMC microbiology 2026 Jan 24;26(1):133
KIN17 facilitates the initiation and progression of renal tumor progression through the PI3K-AKT-mTOR pathway.
Wen Y, Lyu L, Zhang H, Zhang Y, Yang S, Wang Q, Song Y, Wen J
Scientific reports 2026 Jan 19;16(1):5721
Scientific reports 2026 Jan 19;16(1):5721
NAT10 drives hepatocellular carcinoma progression through SQLE-mediated cholesterol biosynthesis and is targetable by remodelin.
Wang Y, Yang X, Dong Y, Yang X, Hou Y, Fu Q, Yan J, Du Y, Zhang Q, Zhou Y, Wu A, Chang S, Xu J, Zhang C, Hu X, Meng H, Sun W, Liu D
iScience 2026 Jan 16;29(1):114488
iScience 2026 Jan 16;29(1):114488
Indirubin treatment was associated with modulation of the PI3K/AKT and MAPK pathways and induction of apoptosis and autophagy.
Xie X, Liu C, Liu X, Hou L, Zhang Y, Huang L, Peng W, Liu Y
Scientific reports 2026 Jan 13;16(1):5155
Scientific reports 2026 Jan 13;16(1):5155
Targeting fatty acid metabolism in hepatic macrophages mitigates acetaminophen-induced liver injury and promotes regeneration in mice.
Jiang X, Wu B, Xie L, Li H, Chen C, Huang P, Chen X, Zhu Q, Wang H, Hu C
Hepatology communications 2026 Jan 1;10(1)
Hepatology communications 2026 Jan 1;10(1)
Dysregulation of Rho-Associated Coiled-Coil Protein Kinase1 Depletes Neural Stem Cell Pool and Impairs Hippocampal Neurogenesis After Traumatic Brain Injury.
Yao C, Jin L, Zhong J, Huang Q, Bao Z, Zhou S, Wang C, Li H, Yuan X, Wang Z, Du N, Yu J, Chen H, Zhang X, Ge H, Wu J
Cell proliferation 2026 Feb;59(2):e70093
Cell proliferation 2026 Feb;59(2):e70093
Saikosaponin D overcomes gemcitabine resistance in pancreatic cancer via AKT/mTOR pathway inhibition and synergistic induction of apoptosis and autophagy.
Zheng R, Liu Y, Zhou S, Liu G, Liu X, Yang Y, Zhang Y
Oncology reports 2026 Feb;55(2)
Oncology reports 2026 Feb;55(2)
Knockdown of ALOX15 alleviates acute coronary syndrome via the FGFR2/PI3K/AKT signaling pathway.
Chen H, Zhu N, Huang S, Guan F, Han S, Ye F, You L
Biomedical reports 2026 Feb;24(2):19
Biomedical reports 2026 Feb;24(2):19
DLGAP5 regulates malignancy and lenvatinib sensitivity of hepatocellular carcinoma through AKT/mTOR/NF-κB pathway.
He B, Deng M, Guan R, Mei J, Zou H, Tang Y, Yang Z, Zheng Z, Lin W, Li S, Guo R, Zhao R, Wei W
European journal of medical research 2026 Feb 9;
European journal of medical research 2026 Feb 9;
Kruppel like factor 12 gene regulates ovarian granulosa cells proliferation and apoptosis via the PI3K/Akt signaling pathway.
Cai J, Zhao B, Bao Z, Li Y, Han X, Chen Y, Wu X
BMC veterinary research 2026 Feb 5;22(1)
BMC veterinary research 2026 Feb 5;22(1)
Mechanistic study of the role of emodin in targeting and inhibiting the Rap1 signaling pathway to regulate epithelial-mesenchymal transition and reverse cisplatin resistance in hepatocellular carcinoma.
Zhang R, Jiao Y, Wang S, Wang L, Leng Y, Xiong Z, Yang M
Translational cancer research 2026 Feb 28;15(2):93
Translational cancer research 2026 Feb 28;15(2):93
Claudin18.2 promote gastric cancer proliferation by activating MCM2/5.
Zheng B, Fu M, Lou F, He Y, Zhao L, Huang X, Xie X, Tan W, Chen Q, Zhang W, Hong Y, Rong K, Lu Y, Zhan P, Tu J, Shi H, Hu T, Xiao L
Scientific reports 2026 Feb 23;16(1)
Scientific reports 2026 Feb 23;16(1)
AIF-1 Drives Corneal Neovascularization by Promoting Inflammatory Macrophage Activation via the MAPK and PI3K/AKT/mTOR Signaling Pathways.
Li Q, Bao Q, Wei C, Xie Y, Zhao S, Yan H, Wu F, Li W, Liu X, Gao H
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
Investigative ophthalmology & visual science 2026 Feb 2;67(2):22
TDP-43 dysfunction compromises UPF1-dependent mRNA metabolism in ALS.
Alessandrini F, Wright M, Kurosaki T, Perloff OS, Ngo M, Kofler JK, Donnelly CJ, Maquat LE, Kiskinis E
Neuron 2026 Feb 18;114(4):640-660.e10
Neuron 2026 Feb 18;114(4):640-660.e10
Leveraging self-healing CASH gel for enhanced paracrine secretion of mesenchymal stem cells to boost endometrial regeneration.
Shao F, An C, Xue Q, Xiao Y, Wang Q, Wang S, Yang X, Pan C, Wang L, Yu X, Zhang Y, Cheng F, Wang H, Wang H
Biomaterials 2026 Aug;331:124098
Biomaterials 2026 Aug;331:124098
Sildenafil suppresses osteoporosis-related bone marrow adiposity by inhibiting Adipogenic differentiation of mesenchymal stem cells.
Wu L, Hu M, Wei E, Pan X, Zhu Q, Wu T, Xiuyun X, Lv L, Dong X, Liu H, Liu Y
Cellular signalling 2026 Aug;144:112539
Cellular signalling 2026 Aug;144:112539
Sodium butyrate ameliorates muscle atrophy in type 2 diabetes-related sarcopenia via the PI3K/Akt/FoxO1 pathway.
Song CY, Yang Y, Hong K
Tissue & cell 2026 Aug;101:103487
Tissue & cell 2026 Aug;101:103487
The GOLM1-ACLY pathway regulates macrophage-secreted EFEMP1 via H3K27ac modifications to drive tumor progression.
Zhen L, Min M, Mo X, Zhao G, Li H, Liu M, Wan L, Yang X, Huang L, Zhang Y, Gao Q, Zhong H, Qiang G, Wu F, Xie Q, Wei C, Zhao R
Journal of advanced research 2026 Apr;82:765-783
Journal of advanced research 2026 Apr;82:765-783
An engineered triple-network alginate/gelatin hydrogel mediates osteochondral regeneration through temporal regulation of the PI3K-AKT pathway.
Zhu Y, Leng P, Liang W, Xu W, Liang H, Yang Y, Si X, Liu X, Yang X, Shi C, Liu M
International journal of biological macromolecules 2026 Apr;358:151622
International journal of biological macromolecules 2026 Apr;358:151622
Panax notoginseng saponins protect the blood-brain barrier against oxidative stress by activating the Akap12-PI3K/AKT-AQP1 signaling axis.
Fan L, Qu S, Miao C, Wu D, Rao Y, Xu W, He Y, Ding R, Song G
International journal of biological macromolecules 2026 Apr;353:151045
International journal of biological macromolecules 2026 Apr;353:151045
Mettl3-Mediated m6A Methylation of Pdgfrb Regulates the Angiogenesis-Dependent Bone Formation.
Zhou S, Zhu Y, Yun L, Li M, Zhang T, Wumiti T, Zhou Q, Chen S, Hu Y, Han Z, Zhang C, Tong K, Zhang Y, Ma Y, Guo Y, Wang L
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71817
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2026 Apr 30;40(8):e71817
Metformin hydrochloride regulates glycolysis and inhibits PEDV replication by inhibition of PI3K-AKT signaling pathway.
Zhang X, Li Y, Yuan J, Li Q, Hu X, Song Z, Sun Z, Song Y, Zhong Y, Liao G, Ding J, Yang S, Song Z
Journal of virology 2026 Apr 21;100(4):e0014726
Journal of virology 2026 Apr 21;100(4):e0014726
Structural characterization and hypoglycemic mechanisms of a Hericium coralloides heteropolysaccharide (HCP-2b) via gut microbiota modulation and PI3K/Akt signaling.
Wang M, Fu H, Lv G, Zhao R, Cai W, Pi X, Zhang Z
Carbohydrate polymers 2026 Apr 15;378:124879
Carbohydrate polymers 2026 Apr 15;378:124879
Inhibition of TRPC6 channel suppresses bladder cancer proliferation by disrupting store-operated calcium entry.
Zha J, Guo X, Liao W, Wu P, Wu Y, Guo Y, Yang W, Gao L
Scientific reports 2026 Apr 14;
Scientific reports 2026 Apr 14;
Argininyl-Fructosyl-Galactose: A Novel Amino Acid Derivative Improves Cisplatin-induced Intestinal Toxicity via Reactive Oxygen Species-mediated Apoptosis Pathway.
Liu W, Zheng YN, Jiang S, Ren S, Tang S, Zhang J, Wang Z, Li W
Current medicinal chemistry 2025;32(14):2809-2823
Current medicinal chemistry 2025;32(14):2809-2823
Synergistic effects of notoginsenoside R1 and saikosaponin B2 in atherosclerosis: A novel approach targeting PI3K/AKT/mTOR pathway and macrophage autophagy.
Wang Y, Liao Q, Mei X, Xu H, Luo L, Huang R, Tang Y, Zhou C
PloS one 2025;20(6):e0326687
PloS one 2025;20(6):e0326687
Integrating bulk and single-cell RNA sequencing reveals SH3D21 promotes hepatocellular carcinoma progression by activating the PI3K/AKT/mTOR pathway.
Tong W, Qin N, Lu T, Liu L, Liu R, Chen J, Luo N
PloS one 2025;20(4):e0302766
PloS one 2025;20(4):e0302766
Cannabidiol Ameliorates Doxorubicin-Induced Myocardial Injury via Activating Hippo Pathway.
Dong T, Li J, Liang X, Wang W, Chen M, Yang G, Wu D
Drug design, development and therapy 2025;19:569-583
Drug design, development and therapy 2025;19:569-583
Exploring the Anti-PANoptosis Mechanism of Dachaihu Decoction Against Sepsis-Induced Acute Lung Injury: Network Pharmacology, Bioinformatics, and Experimental Validation.
Yang Z, Kao X, Zhang L, Huang N, Chen J, He M
Drug design, development and therapy 2025;19:349-368
Drug design, development and therapy 2025;19:349-368
Unveiling the Therapeutic Potential of Banxia Xiexin Decoction in Alzheimer's Disease: Insights From Network Pharmacology and Experimental Validation.
Qin G, Song R, Sun J, Dai J, Wang W, Meng F, Wang D, Liu Z, Sun B, Li C
Drug design, development and therapy 2025;19:2133-2155
Drug design, development and therapy 2025;19:2133-2155
Qimai Feiluoping Decoction Inhibits EndMT to Alleviate Pulmonary Fibrosis by Reducing PI3K/AKT/mTOR Pathway-Mediated the Restoration of Autophagy.
Ma J, Ding L, Zang X, Yang Y, Zhang W, Li X, Zhao D, Zhang Z, Wang Z, Zhao L, Tong X
Journal of inflammation research 2025;18:8447-8475
Journal of inflammation research 2025;18:8447-8475
Fu-Fang-Qi-Di-Hua-Yu-Tang Improves Diabetic Macrovascular Disease via PI3K/AKT Pathway Regulation.
Zhang S, Yan M, Liang P, Zhang Y, Liu J, Huang H, Li G, Wu H
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265
Diabetes, metabolic syndrome and obesity : targets and therapy 2025;18:2247-2265
The Role of Dectin-1-Akt-RNF146 Pathway in β-Glucan Induced Immune Trained State of Monocyte in Sepsis.
Guo C, Xu P, Luo W, Zhang J, Sun X, Hoang H, Ma D, Wu D, Zhong J, Miao C
Journal of inflammation research 2025;18:1147-1165
Journal of inflammation research 2025;18:1147-1165
Long Non-Coding RNA lncTAF15:1-1 Promotes CCL5 Secretion and Cell Migration of Monocyte-Derived Dendritic Cells via PI3K/AKT/mTOR Pathway in Systemic Lupus Erythematosus.
Xiang M, Sun Z, Ge Y, Zhang Z, Zheng C, Gao Z, Wang J, Xu J, Liang J, Wang Y
Journal of inflammation research 2025;18:10389-10402
Journal of inflammation research 2025;18:10389-10402
Extracellular vesicles-miR-205-5p inhibits lymphatic metastasis in pancreatic cancer through diffusely downregulating VEGFA.
Wang Y, Qin C, Zhao Y, Zhao B, Li Z, Li T, Zhang X, Wang W
Journal of Cancer 2025;16(7):2197-2211
Journal of Cancer 2025;16(7):2197-2211
Levocarnitine improves cardiac energy metabolic remodeling in myocarditis mice.
Yang S, Li X, Lu Z, Xu X, Guo Z, He B
Frontiers in pharmacology 2025;16:1706936
Frontiers in pharmacology 2025;16:1706936
Dual function antibody targeting αvβ3 and PD-L1 provide a promising strategy for solid tumor therapy.
Li G, Li W, Wang L, Bi Y, Wang Y, Zheng X, Hao R, Yin Y, Yu Y, Mu H, Li J, Ma X, Zhou S, Han J, Wang G, Huang R
Frontiers in immunology 2025;16:1691774
Frontiers in immunology 2025;16:1691774
CRTC1 enhances PD-L1-mediated tumor immunosuppression in non-small cell lung cancer via the Notch1/Akt signaling pathway.
Feng X, Shi Y, Yuan F, Hu Y, Tang X, Zhang W, Gan J, Sun L, Cao L
Frontiers in immunology 2025;16:1658679
Frontiers in immunology 2025;16:1658679
Integrative bioinformatics and experimental validation unveil CRISP3 as a hypoxia-, epithelial mesenchymal transition-, and immune-related prognostic biomarker and therapeutic target in breast cancer.
Ren Y, Li Y, Wang Z, Cui Y, Xing Z, Zhang Y, Cao N, Yu Y, Guo Y, Li X
Frontiers in immunology 2025;16:1634399
Frontiers in immunology 2025;16:1634399
Sphingosine-1-phosphate alleviates colitis by regulating macrophage polarization and PI3k-Akt signaling.
Hu L, Yang Z, Zhang Y, Du C, Yang Y, Chang Z, Li X, Shan Z
Frontiers in immunology 2025;16:1622094
Frontiers in immunology 2025;16:1622094
Study on mechanism of action of β-elemene in inhibiting cisplatin resistance in lung cancer through LncRNA LINC00511.
Deng X, Hu C, Li L, Yang G, Li C, Zhang W, Cheng G
Frontiers in pharmacology 2025;16:1586657
Frontiers in pharmacology 2025;16:1586657
Small extracellular vesicles from human umbilical cord mesenchymal stem cells delivering miR-202-5p alleviate renal ischemia-reperfusion injury by targeting the GOLIM4/PI3K/AKT axis.
Peng X, Shi W, Yu H, Feng Z, Wei Z, He W, Gou X, Xie Y
Frontiers in immunology 2025;16:1586174
Frontiers in immunology 2025;16:1586174
Ruminococcus bromii-generated acetate alleviated Clonorchis sinensis-induced liver fibrosis in mice.
Li C, Cheng C, Jiang L, Zhong X, Huang G, Mo G, Cao D, Peng X
Frontiers in microbiology 2025;16:1532599
Frontiers in microbiology 2025;16:1532599
Brigatinib can inhibit proliferation and induce apoptosis of human immortalized keratinocyte cells.
Yang Q, Zhao D, Ju L, Cao P, Wei J, Liu Z
Frontiers in pharmacology 2025;16:1524277
Frontiers in pharmacology 2025;16:1524277
Elucidating the pharmacological foundations and mechanisms of the Sihai Shuyu formula in treating Graves' disease through integrated serum metabolomics and network pharmacology with molecular docking techniques.
Liu X, Li X, Huang W, Cui Y, Cheng F, Chen G, Mao X, Liu C, Xu S
Frontiers in endocrinology 2025;16:1511808
Frontiers in endocrinology 2025;16:1511808
Curdione combined with borneol treats bacterial mixed HPV infection by regulating the crosstalk among immune cells.
Liu J, Shu T, Mu Y, Zheng W, Lu X, Tao H
Frontiers in immunology 2025;16:1503355
Frontiers in immunology 2025;16:1503355
Entrectinib can induce nerve cell damage by inhibiting PI3K-AKT and TGF-β signaling pathways.
Tang Q, Dong J, Zhang F, Zhao D, Yang Q, Wen J, Sun Y, Wei J, Liu Z
Frontiers in pharmacology 2025;16:1489210
Frontiers in pharmacology 2025;16:1489210
ER-α36 prevents high glucose-induced cellular senescence and apoptosis in renal tubular cell.
Yu D, Luo L, Liang Y, Zhou H, Xiao Y, An X, Wang Y, Xu Z, Sun W, Wang W
Frontiers in endocrinology 2025;16:1426854
Frontiers in endocrinology 2025;16:1426854
Nanodelivery of Y-27632 by RGD-modified liposome enhances radioimmunotherapy of hepatocellular carcinoma via tumor microenvironment matrix stiffness reprogramming.
Shen Y, Zheng Z, Hu X, Zhou Z, Xu Y, Wang S, Yu S, He X, Xu X
Theranostics 2025;15(16):8569-8586
Theranostics 2025;15(16):8569-8586
MiR-424-5p acts as an oncogene in Hep3B cells by activating the PI3K/AKT signaling pathway.
Ding Z, Qi S, Hu M, Wang L, Tang Y, Sun J, Zheng L, Li Y, Li L, Ma Q, Tang H
Frontiers in oncology 2025;15:1726596
Frontiers in oncology 2025;15:1726596
Role of SUV39H2 in shaping the malignant phenotype of triple-negative breast cancer.
Wang ZW, Hu S, Chen Y, Lu Y, Li SF, Deng Y, Jiang HT
Frontiers in oncology 2025;15:1679640
Frontiers in oncology 2025;15:1679640
RNLS promotes ovarian cancer growth and inhibits ferroptosis via mediating STAT3.
Lin L, Xie Z, Zhong P, Chen J, Ma N, Li L, Lin A, Chen L
Frontiers in oncology 2025;15:1604377
Frontiers in oncology 2025;15:1604377
The m6A demethylase FTO suppresses glioma proliferation by regulating the EREG/PI3K/Akt signaling pathway.
Zhai Y, Li C, Cao L, Zhang S, Liu X, Ren J, Liu Y
Frontiers in cell and developmental biology 2025;13:1667990
Frontiers in cell and developmental biology 2025;13:1667990
The role of HDAC2 inhibition in cardioprotection against doxorubicin-induced myocardial injury.
Liu J, Fu W, Wang X, Liang Z, Meng F
Frontiers in cardiovascular medicine 2025;12:1557119
Frontiers in cardiovascular medicine 2025;12:1557119
Lacticaseibacillus rhamnosus HF01 postbiotics reprogram gut microbial tryptophan metabolism to coordinate enterohepatic barrier-insulin signaling axis.
Sun Y, Liu X, Zhao L, Li D, Guan K, Ma Y, Wang R, Li Q
Current research in food science 2025;11:101111
Current research in food science 2025;11:101111
HDAC1/2-mediated deacetylation of KLF9 promotes the malignant progression of nasopharyngeal carcinoma via CDH17.
Zhang K, Peng X, Zhou P, Li X, Shen L, Yang L, Zhou Q
Oncogene 2025 Sep;44(35):3183-3198
Oncogene 2025 Sep;44(35):3183-3198
Protective effects of berberine on MASLD: regulation of glucose and lipid metabolism through PI3K/Akt and STING pathways.
Ji J, Li Y, Xu T, Shao Q, Sun Z, Chen S, Zhang D, Wang Q, Wang X, Ma C, Cheng F
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12405-12420
Naunyn-Schmiedeberg's archives of pharmacology 2025 Sep;398(9):12405-12420
Recombinant chromosome 6 open reading frame 120 protein promotes angiogenesis and endothelial‑to‑mesenchymal transition in human umbilical vein endothelial cells via the PI3K/Akt signaling pathway.
Lin Y, Wang X, Li Y, Cui X, Zhu N, Li X
Molecular medicine reports 2025 Sep;32(3)
Molecular medicine reports 2025 Sep;32(3)
Ubiquitin-specific protease 7-mediated stabilization of discoidin domain receptor 1 drives progression of TP53-Mutant cancers.
Xue Y, Xiu B, Yang M, Zhang Y, Yang C, Zhang L, Yan Y, Luo X, Huang Y, Mei H, Li G, Zhou L, Chen Y, Zhang W, Qian C, Zhang P, Liu J, Liang A, Zeng Y, Yang J
The Journal of biological chemistry 2025 Sep;301(9):110515
The Journal of biological chemistry 2025 Sep;301(9):110515
Fuhu Lijie Tang treats rheumatoid arthritis through multitarget therapy from autoantigen formation to bone destruction.
Yao Z, He J, Hu M, Yan P, Xu Q, Zhang Q, Lin Y, Liao J, Cai X, Liu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Sep;145:157086
Gut Metabolite Indole-3-Propionic Acid Regulates Macrophage Autophagy Through PPT1 Inhibiting Aging-Related Myocardial Fibrosis.
Lu J, Wang H, Zhang H, Li J, Li H, Chen Q, Han D, Liu J, Lv L, Xiong J, Yuan K, Wei X, Sheng S, Liu F, Shi Y, Dong Z, Li Y
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01070
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(34):e01070
Targeting the IRS1 macromolecular signaling node by Trienomycin a triggers cytoprotective autophagy in pancreatic adenocarcinoma.
Li MJ, Zhang R, Sheikho A, Tang JJ, Gao YQ, Huang WW, Gao JM
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
International journal of biological macromolecules 2025 Sep 8;328(Pt 2):147547
Study on the role of FN1 in chronic obstructive pulmonary disease.
Wang F, Zhang J, Yuan Y, Zhou J, Pang S, Li X, Qiu A
Gene 2025 Sep 5;963:149551
Gene 2025 Sep 5;963:149551
Investigating the Mechanism of Yiqi Huoxue Jieyu Granules Against Ischemic Stroke Through Network Pharmacology, Molecular Docking and Experimental Verification.
Chen Y, Zhou H, Zhang T, Wan H
Pharmaceuticals (Basel, Switzerland) 2025 Sep 5;18(9)
Pharmaceuticals (Basel, Switzerland) 2025 Sep 5;18(9)
IRS2/FOXO1 mitigates osteoarthritis by regulating chondrocyte autophagy and mitochondrial function.
Qin C, Chen K, Sun Y, Wang C, Yu Y, Zhu H, Zou G
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):293
Molecular medicine (Cambridge, Mass.) 2025 Sep 26;31(1):293
Antidepressant effects of total phenols and total saponins of Kai-Xin-San mediated by synaptic plasticity induced by BDNF/TrkB/Akt pathway.
Tang YN, Bai YF, Dong A, Rao QL, Wu HH, Wang CG, Xu YT
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120423
Journal of ethnopharmacology 2025 Sep 25;353(Pt B):120423
Comparison of the therapeutic efficacy of leukocyte-poor and leukocyte-rich platelet-rich plasma in rabbit knee osteoarthritis and the study of autophagy mechanism.
Sun L, Wang Y, Zhang K, Chen X, Shi H
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
BMC musculoskeletal disorders 2025 Sep 24;26(1):857
Human papillomavirus-related syntaxin 11 reprograms tumor-associated macrophages to induce breast cancer cell apoptosis via PI3K/AKT signaling.
Hu C, Hu T, Wen J, Jia Z
Molecular medicine (Cambridge, Mass.) 2025 Sep 2;31(1):285
Molecular medicine (Cambridge, Mass.) 2025 Sep 2;31(1):285
Reprogramming Macrophage via an Antigen Phagocytosis-Presentation Nanoenhancer for Improved Cancer Immunotherapy.
Liu L, Zhang J, Wang S, He Z, Wang X, Tian L, Li M, Long G, Zhu S, Jiang Z, Li S
ACS nano 2025 Sep 2;19(34):31077-31091
ACS nano 2025 Sep 2;19(34):31077-31091
Strontium-Loaded Chitosan/Wood Hydrogel with Anisotropic Cellular Architecture for Enhanced Critical Bone Regeneration.
Zhang M, Yang J, Zhang J, Wo K, Dong X, Deng H, Wang M, Yang C
ACS applied materials & interfaces 2025 Sep 10;17(36):50302-50316
ACS applied materials & interfaces 2025 Sep 10;17(36):50302-50316
Ursolic acid sensitizes bladder cancer to gemcitabine chemotherapy by concurrently targeting PI3K/AKT and JNK pathways.
Huang X, Sun Y, Tong H, Zhu J, Pan J, Wen P, He W
Translational andrology and urology 2025 Oct 31;14(10):2902-2916
Translational andrology and urology 2025 Oct 31;14(10):2902-2916
MicroRNA-592 suppresses breast cancer progression by targeting CYP20A1 to modulate the CHOP pathway.
Pan R, Jiang S, Su J, Zhang C, Li X, He K
Journal of physiology and biochemistry 2025 Nov;81(4):1173-1184
Journal of physiology and biochemistry 2025 Nov;81(4):1173-1184
METTL16 promotes progression of clear cell renal cell carcinoma via up-regulating N6-methyladenosine modification of KLK4 mRNA.
Fan B, Niu Y, Li T, Chen H, Zeng K, Li S, Ma Y
Molecular and cellular biochemistry 2025 Nov;480(11):5741-5751
Molecular and cellular biochemistry 2025 Nov;480(11):5741-5751
CXCL10 Involvement in Vestibular Migraine via the PI3K/AKT Signaling Pathway.
Song MM, Chen TY, Song SN, Gao YJ, Li CX, Xu SY
CNS neuroscience & therapeutics 2025 Nov;31(11):e70655
CNS neuroscience & therapeutics 2025 Nov;31(11):e70655
TBRG4 regulates ubiquitination of Beclin1 and participates in autophagy pathway to inhibit intervertebral disc degeneration.
Cui X, Zhang F, Cui D, Zhang W, Wu H, Chen X, Yu H
The spine journal : official journal of the North American Spine Society 2025 Nov;25(11):2569-2584
The spine journal : official journal of the North American Spine Society 2025 Nov;25(11):2569-2584
Astragaloside IV delayed the epithelial-mesenchymal transition in peritoneal fibrosis by inhibiting the activation of EGFR and PI3K-AKT pathways.
Huang Y, Chu CL, Qiu WH, Chen JY, Cao LX, Ji SY, Zhu B, Wang GK, Shen QQ
Journal of integrative medicine 2025 Nov;23(6):694-705
Journal of integrative medicine 2025 Nov;23(6):694-705
Small nucleolar RNA host gene 1 (SNHG1) facilitates gemcitabine chemosensitivity in gallbladder cancer by regulating the miR-23b-3p/phosphatase and tensin homolog (PTEN) pathway.
Wang H, Gu Y, Guo M, Zhan M, He M, Zhang Y, Yang L, Liu Y
Chinese medical journal 2025 Nov 5;138(21):2783-2792
Chinese medical journal 2025 Nov 5;138(21):2783-2792
Lipoxin A4 Regulates M2 Macrophage-Derived Exosomal miR-25-5p to Protect Cell Pyroptosis in Bronchopulmonary Dysplasia.
Chen T, Yang Y, Zhang Y, You M, Zhou Y, Ning T, Lu H, Wang J, Peng S, Chen X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71218
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Nov 30;39(22):e71218
Single-Nucleus Transcriptomic Landscape of Neonatal Mice Hippocampus During Sevoflurane-Induced Neurotoxicity.
Li Y, Qiu X, Zhang J, Cai Z, Shi L, Zhang Q
Neurochemical research 2025 Nov 3;50(6):347
Neurochemical research 2025 Nov 3;50(6):347
Dapagliflozin ameliorates high glucose-induced peritoneal fibrosis through downregulation of ENKUR/PI3K/AKT signaling pathway.
Liu J, Xu X, Zhang L, Jiang T, Zhao Z, Xiao J
Scientific reports 2025 Nov 3;15(1):38334
Scientific reports 2025 Nov 3;15(1):38334
Autophagy-targeted intervention synergized with pegaspargase: an innovative therapeutic paradigm for pancreatic cancer.
Zhou D, Ding Z, Yin T, Huang M, Zhang X, Cao H, Wang C
Cancer cell international 2025 Nov 28;25(1):428
Cancer cell international 2025 Nov 28;25(1):428
Histone demethylase KDM9 activates the CCND1/AKT pathway to promote the malignant progression of gliomas through interaction with BRD2.
Cheng J, Peng X, Tang S, Zhou P, Zhou Z, Mao Z, Li D, Yang L, Peng J
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):423
Cellular and molecular life sciences : CMLS 2025 Nov 26;82(1):423
Breviscapine targets EGFR and SRC to abrogate diabetes-driven GPX4 lactylation and ferroptosis resistance in gastric cancer.
Hu HM, Deng JL, Pan Y, Wang ZH, Zhang J, Yu Gu X, Fan SX, Zhao JZ
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157387
Cistanche deserticola extract and its active components, echinacoside, ameliorate sarcopenia by activating the IGF-1/PI3K-AKT pathway to modulate ferroptosis.
Wang X, Zhu L, Du R, Li A, Li N, Liu X, Zhang Y, Liu X, Wang Q, Han C, Qu C, Zou W, Liu J, Wang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157378
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157378
Zhenqi Fuzheng Granule targets the SCFAs-GPR109A axis to enhance PD-1 antibody efficacy via immunometabolic remodeling in colorectal cancer.
Guo L, Yi J, Zhang A, Zheng X, Wang M, Yang F, Kong X, Meng J
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157312
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157312
Machine Learning Identifies FLNA as a Key Molecular Target Regulating Neuronal Apoptosis after Spinal Cord Injury.
Pei Y, Hu Y, Feng G, Xu Q, Zhou S, Zhang N, Zhang C, Huang F, Zhang L
Journal of molecular neuroscience : MN 2025 Nov 15;75(4):151
Journal of molecular neuroscience : MN 2025 Nov 15;75(4):151
Exosomal lncRNA MIR210HG derived from hypoxic TAMs promotes the metastasis of triple negative breast cancer.
Feng L, Wang Y, Wang X, Li B, Liu Y, Zhang W, Ji J, Shao L, Guo X
International immunopharmacology 2025 Nov 14;165:115416
International immunopharmacology 2025 Nov 14;165:115416
NRG1/PDGFC loop between fibroblasts and cancer cells drives paclitaxel resistance via ferroptosis suppression in breast cancer.
Duan WL, Wang XJ, Gu LH, Guo A, Ding YY, Lin P, Zhang BG
Cell death discovery 2025 Nov 10;11(1):520
Cell death discovery 2025 Nov 10;11(1):520
AATF alleviates cerebral ischemia-reperfusion injury by suppressing endoplasmic reticulum stress-induced ferroptosis through upregulating the PI3K/Akt pathway.
Lei B, Luo W, Li Q, Wu H, Chen L, Chen S, Wu J, Zheng N
Neurological research 2025 Nov 10;:1-17
Neurological research 2025 Nov 10;:1-17
Calcitriol Modulates Hippocampal Axon Guidance Through Enhanced EfnA4-Mediated PI3K/AKT Signaling in an Autism Mouse Model.
Gong T, Sun R, Bai J, Liu X, He C, Jiang Q, Wang Q, Qi Y, Ding W, Shen J, Lei L, Shan Z
CNS neuroscience & therapeutics 2025 May;31(5):e70429
CNS neuroscience & therapeutics 2025 May;31(5):e70429
The Potential Hepatocyte Differentiation Targets and MSC Proliferation by FH1.
Luo S, Wu F, Jin Y, Liu D
Journal of cellular and molecular medicine 2025 May;29(9):e70601
Journal of cellular and molecular medicine 2025 May;29(9):e70601
AKT1 Phosphorylates FDX1 to Promote Cuproptosis Resistance in Triple-Negative Breast Cancer.
Sun Z, Xu H, Lu G, Yang C, Gao X, Zhang J, Liu X, Chen Y, Wang K, Guo J, Li J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2408106
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 May;12(17):e2408106
The Immunotherapeutic Target ANLN Promotes Renal Clear Cell Carcinoma by Regulating PI3K/Akt and P53 Signaling Pathways.
Shan L, Gu GJ, Xiang CC, Zuo ED, Lian L, Cheng X
BioFactors (Oxford, England) 2025 May-Jun;51(3):e70023
BioFactors (Oxford, England) 2025 May-Jun;51(3):e70023
Xiao-Chai-Hu granule alleviates influenza virus-induced pneumonia by regulating TLR4-PI3K-Akt/p38 MAPK-NF-κB pathways.
Li JJ, Chen ZH, Liang WT, Yang YD, Xie TY, Chen DJ, Yang X, Wu PL, Liang XW, Zou HP, Zhang JH, Shi W, Zhang FX
Journal of ethnopharmacology 2025 May 28;348:119760
Journal of ethnopharmacology 2025 May 28;348:119760
Cell-free extracts from human fat tissue attenuate ischemic injury in cardiomyocytes in a murine model.
Yang TY, Sun Y, Zhang WJ, Wang CQ, Zhou J
World journal of stem cells 2025 May 26;17(5):105394
World journal of stem cells 2025 May 26;17(5):105394
Study on the molecular mechanism of UBA52 and BARD1 regulating hepatocellular carcinoma through the PI3 K/AKT signaling pathway.
Yang C, Zhang Y, Liu Y, Wu X, Sun F
Discover oncology 2025 May 21;16(1):840
Discover oncology 2025 May 21;16(1):840
Overexpression of Tgm2 in Chinese Hamster Ovary Cells Enhances Recombinant Monoclonal Antibody Expression and Promotes Cell Proliferation through Reduction of Apoptosis.
Zhang HJ, Zhao Q, Zhang M, Yang LL, Abiti J, Han MM, Gao YP, Lu JT, Wang JN, Ji MY, Zhang X, Wang W, Qiu LL, Wang XY, Wang TY, Jia YL
ACS synthetic biology 2025 May 16;14(5):1802-1812
ACS synthetic biology 2025 May 16;14(5):1802-1812
TRPV4 Blockage Inhibits the Neurogenesis in the Adult Hippocampal Dentate Gyrus Following Pilocarpine‑Induced Status Epilepticus.
Qi X, Chen X, Luo Q, Liu L, An D, Sha S, Du Y, Wu C, Chen L
Molecular neurobiology 2025 Mar;62(3):3615-3629
Molecular neurobiology 2025 Mar;62(3):3615-3629
Multi-omic profiling of sarcopenia identifies disrupted branched-chain amino acid catabolism as a causal mechanism and therapeutic target.
Zuo X, Zhao R, Wu M, Wang Y, Wang S, Tang K, Wang Y, Chen J, Yan X, Cao Y, Li T
Nature aging 2025 Mar;5(3):419-436
Nature aging 2025 Mar;5(3):419-436
Cooperative blockade of FLT3 and ALK synergistically suppresses growth of osteosarcoma.
Zhang W, Qi L, Xu H, Yin C, Yu Z, Xu R, Feng C, Ren X, Tu C, Li Z
Oncogene 2025 Mar;44(7):427-438
Oncogene 2025 Mar;44(7):427-438
Preparation, characterization, and stability of selenium nanoparticles decorated with Mori Fructus polysaccharide and its protective effects in bisphenol A-induced Sertoli cells.
Cao M, Qian Y, Sun Z, Liu S, Zheng R, Zhao L, Chen G
International journal of biological macromolecules 2025 Mar;294:139463
International journal of biological macromolecules 2025 Mar;294:139463
2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione mediates the effect of ROS-enhanced PI3K/Akt/mTOR pathway on autophagy in breast cancer.
Chen L, Chen M, Xie Y, Zhang Y, Mo S, He Y, Liang T, Liao Y, Huang R, Huang G, Han C, Pham TTH
FEBS open bio 2025 Mar;15(3):474-489
FEBS open bio 2025 Mar;15(3):474-489
Targeting TTK Inhibits Tumorigenesis of T-Cell Lymphoma Through Dephosphorylating p38α and Activating AMPK/mTOR Pathway.
Liu B, Lu T, Ding M, Zhou X, Jiang Y, Shang J, Sun W, Hu S, Wang X, Zhou X
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2413990
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Mar;12(10):e2413990
Edaravone dextranol alleviates ferroptosis, Cuproptosis, and blood-brain barrier damage after acute cerebral infarction.
Jin G, Han W, Duan T, Xue Z, Song C, Xu Y, Yu M
Metabolic brain disease 2025 Mar 3;40(3):134
Metabolic brain disease 2025 Mar 3;40(3):134
Fatty acid synthase inhibitor cerulenin attenuates glioblastoma progression by reducing EMT and stemness phenotypes, inducing oxidative and ER stress response, and targeting PI3K/AKT/NF-κB axis.
Pekmez M, Mete ŞB, Aksüt Y, Öğütcü İ, Baştürk FN, Gerçek YC, Şengelen A
Medical oncology (Northwood, London, England) 2025 Mar 25;42(5):136
Medical oncology (Northwood, London, England) 2025 Mar 25;42(5):136
Role of octamer transcription factor 4 in proliferation, migration, drug sensitivity, and stemness maintenance of pancreatic cancer cells.
Shi XY, Wang XL, Zhao J, Yang SH, Zhang CH
World journal of clinical oncology 2025 Mar 24;16(3):100723
World journal of clinical oncology 2025 Mar 24;16(3):100723
Microsecond pulsed electric fields induce myocardial ablation by secondary mitochondrial damage and cell death mechanisms.
Gao Q, Zhang M, Chen R, Teng P, Dai X, Wu B, Hong L, Ma L, Liu L, Wu S, Li M
Scientific reports 2025 Mar 24;15(1):10132
Scientific reports 2025 Mar 24;15(1):10132
Low intensity pulsed ultrasound alleviates synovial fibrosis in osteoarthritis via the PI3K/AKT pathway.
Liao Q, Chen J, Liu G
Scientific reports 2025 Mar 20;15(1):9644
Scientific reports 2025 Mar 20;15(1):9644
Effect of fecal microbiota transplantation on diabetic wound healing through the IL-17A-mTOR-HIF1α signaling axis.
Peng C, Lei P, Qi H, Zhu Q, Huang C, Fu J, Zhao C
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Applied and environmental microbiology 2025 Mar 19;91(3):e0201924
Dichloroacetate protects against sulfur mustard-induced neurotoxicity via the PDK/PDH axis and Akt/Nrf2 pathway.
Zhang S, Gong Y, Cen J, Pei Z, Wei A, Luo Z, Zhao X, Mao G, Zhang X, Xu Q, Sun M, Meng WQ
Free radical biology & medicine 2025 Mar 1;229:154-167
Free radical biology & medicine 2025 Mar 1;229:154-167
Insufficient expression of COL6A1 promotes the development of early-onset severe preeclampsia by inhibiting the APJ/AKT signaling pathway.
Qi G, Gong Y, Li Y, Jin Y, Chi S, Zhang W, Luo X
Cell death discovery 2025 Mar 1;11(1):81
Cell death discovery 2025 Mar 1;11(1):81
TSPAN31 Activates Fatty Acid Metabolism and PI3K/AKT Pathway to Promote Tumor Progression in Breast Cancer.
Luo W, Sun Y, Cao L
Molecular carcinogenesis 2025 Jun;64(6):1078-1089
Molecular carcinogenesis 2025 Jun;64(6):1078-1089
Carnosol mitigates Ang II-stimulated vascular injury and oxidative stress by directly binding to FAK and inhibiting its activation.
Jiang Y, Zheng Z, Wang J, Liao Y, Jia Z, Lin W, Xu D, Wang J, Wu G, Liang G, Ye B
Inflammopharmacology 2025 Jun;33(6):3349-3362
Inflammopharmacology 2025 Jun;33(6):3349-3362
Mechanistic study of Liquiritigenin inhibiting bladder cancer cell proliferation and migration by regulating STING1.
Li W, Yin Q, Qiu Y, Liu J, Wang J, Li C, Zhang D, Zhang P, Lv H, Lv Y, Wang Y
Cancer genetics 2025 Jun;294-295:156-170
Cancer genetics 2025 Jun;294-295:156-170
Kaempferol targets Src to exert its chemopreventive effects on mammary tumorigenesis via regulation of the PI3K/AKT pathway.
Wang P, Ma Y, Rao X, Luo Q, Xiao X, Wang T, Long F
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156701
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Jun;141:156701
α9 Nicotinic Acetylcholine Receptor Promotes Tumor Proliferation and Suppresses Ferroptosis in Triple-Negative Breast Cancer.
Feng X, Tian Y, Guo X, Lei JH, Yu J, Zheng C, Chen M, Ding RB, Kwok HF, Luo S, Bao J
Biomolecules 2025 Jun 8;15(6)
Biomolecules 2025 Jun 8;15(6)
IL-37 inhibited inflammation to improve gestational diabetes mellitus through the GSK3/NF-κB pathway.
Song M, Zhang G
Diabetology & metabolic syndrome 2025 Jun 5;17(1):193
Diabetology & metabolic syndrome 2025 Jun 5;17(1):193
SOX3 facilitates granulosa cell proliferation and suppresses cell apoptosis through modulating PI3K/AKT pathway by targeting SPP1.
Cai R, Li C, Shi W, Xie F, Fan M, Zhang H, Liu Z, Chen Y, Hong Q
Cellular and molecular life sciences : CMLS 2025 Jun 30;82(1):266
Cellular and molecular life sciences : CMLS 2025 Jun 30;82(1):266
Oleanolic Acid Restores Drug Sensitivity in Sorafenib-resistant Hepatocellular Carcinoma: Evidence from In Vitro and In Vivo Studies.
Li T, Shen X, Zhang T, Ren J, Wang W, Wang D, Zhang P
Journal of clinical and translational hepatology 2025 Jun 28;13(6):469-483
Journal of clinical and translational hepatology 2025 Jun 28;13(6):469-483
SETDB1 promotes mammalian liver regeneration by stimulating cytokine CSF3 in hepatocytes.
Huang XY, Yang D, Liu YZ, Zhang EX, Yang Q, Kang W, Zhang XO, Shi J, Song CQ
Cell reports 2025 Jun 24;44(6):115843
Cell reports 2025 Jun 24;44(6):115843
Cytohesin-4/ARF6 facilitates the progression of acute myeloid leukemia through activating PIK3R5/PI3K/AKT pathway.
Qiu XF, He CM, Zeng YM, Deng XL, Liang GL, Zhong MX, Zou M, Xiong XJ, Zhang JD, Ye Y, Niu Q, Chen XL
iScience 2025 Jun 20;28(6):112634
iScience 2025 Jun 20;28(6):112634
An exploration of the protective effects of Ginsenoside Rb1 against acute lung injury using network pharmacology, molecular docking, molecular dynamics simulations, and in vivo experiments.
Zhang L, Xu SY, Shi MY, Wang H, Ding J, Tong JB, Zhu J, Li ZG, Yang QJ
International immunopharmacology 2025 Jun 17;158:114822
International immunopharmacology 2025 Jun 17;158:114822
Regulator of chromosome condensation 1 promotes hepatocellular carcinoma proliferation via cell-division-cycle-associated-8 dependent phosphoinositide 3-kinase/protein kinase B signaling.
Wang YT, Yong YL, Liu ZK, Shen YX, Yang XM, Chen ZN
World journal of gastrointestinal oncology 2025 Jun 15;17(6):106080
World journal of gastrointestinal oncology 2025 Jun 15;17(6):106080
Guyuan Jiannao decoction improves neurovascular unit dysfunction by regulating PI3K/AKT/NF-κB signaling pathway in cerebral small vessel disease rats.
Zhong Z, Long H, Li N, Liu T, Wu M, Wang J, Liu M, Zhang X, Mei Z, Fang R, Ge J, Meng P
Journal of ethnopharmacology 2025 Jun 12;349:119942
Journal of ethnopharmacology 2025 Jun 12;349:119942
Comprehensive multi-omics analysis of histone acetylation modulators identifies ASH1L as a novel aggressive marker for osteosarcoma.
Ni C, Sun Q, Yin H
Discover oncology 2025 Jun 12;16(1):1070
Discover oncology 2025 Jun 12;16(1):1070
Pharmacological inhibition of Septins with Forchlorfenuron attenuates thrombus formation in experimental thrombotic mice models with modulating multiple signaling pathways in platelets.
Hao Z, Yan M, Tuerhong R, Zhang L, Zhang Z, Alam H, Wu J, Qin Y, Zhao F, Shi L
Journal of advanced research 2025 Jul;73:517-533
Journal of advanced research 2025 Jul;73:517-533
Asiaticoside enhances the anti-tumor effect of anti-PDL1 by regulating T cell activity through increasing LCK activity.
Ren Q, Wang F, Du F, He C, Wang X, Wang J, Zhang Z, Sun Y
Pathology, research and practice 2025 Jul;271:155995
Pathology, research and practice 2025 Jul;271:155995
The Tumor-Suppressive Role of miR-204-5p Through Targeting Ezrin in Breast Cancer: Experimental Evidence From Cell Lines and Clinical Samples.
Dong T, Zhou H, Tang J
Clinical breast cancer 2025 Jul;25(5):e588-e596
Clinical breast cancer 2025 Jul;25(5):e588-e596
LACTB promotes cell differentiation and inhibits cell proliferation in colorectal cancer.
Ma L, Huang G, Lin C, Li X, Liu C, Huang W, Zhang Q, Luo Y
Biochimica et biophysica acta. General subjects 2025 Jul;1869(8):130816
Biochimica et biophysica acta. General subjects 2025 Jul;1869(8):130816
A Dual Approach with Organoid and CRISPR Screening Reveals ERCC6 as a Determinant of Cisplatin Resistance in Osteosarcoma.
Xu R, Zhu S, Zhang W, Xu H, Tu C, Wang H, Wang L, He N, Liu T, Guo X, Ren X, Li Z
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2500632
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Jul;12(28):e2500632
Moesin silencing enhances the radiosensitivity of glioblastoma by inhibiting DNA damage repair via CD44/AKT1 signaling pathway.
Ding X, Wang Y, Shao Z, Wen X, Wang B, Liu G, Xu C, Chai L, Qiu H, Zhang L
Discover oncology 2025 Jul 31;16(1):1451
Discover oncology 2025 Jul 31;16(1):1451
Elevated SLC4A11 expression promotes OV progression via interaction with EGFR.
Peng Q, Sun Y, Wang R, Zhang S, Hu L, Teng Y, Zhu X
Scientific reports 2025 Jul 28;15(1):27439
Scientific reports 2025 Jul 28;15(1):27439
Schisandrin A ameliorates the diabetes-associated memory impairment by alleviating inflammation and ferroptosis.
Ma G, Lei M, Guo S, Zhang Y, Sun Y, Ji H, Ouyang C, Yang X, Zhang Y, Liu X, Zhao B, Guo X
Acta biochimica et biophysica Sinica 2025 Jul 1;57(10):1647-1659
Acta biochimica et biophysica Sinica 2025 Jul 1;57(10):1647-1659
Activated mTORC1 signaling pathway aggravates cisplatin induced oxidative damage by inhibiting autophagy in mouse cochlear hair cells.
Xu NN, Wen YC, Pan J, Shu F, Qu JX, Qi XF, Tang J
Neuropharmacology 2025 Jul 1;272:110433
Neuropharmacology 2025 Jul 1;272:110433
In-Depth Examination of TPBG as a New Predictive Indicator for Gastric Cancer.
Yang L, Weng C, Zhang Y, Zhao Y, Chen K, Li G, Zhong X, He C
Journal of cellular and molecular medicine 2025 Jan;29(2):e70354
Journal of cellular and molecular medicine 2025 Jan;29(2):e70354
IL-17A's role in exacerbating radiation-induced lung injury: Autophagy impairment via the PP2A-mTOR pathway.
Liu L, Yi G, Li X, Chen C, Chen K, He H, Li J, Cai F, Peng Y, Yang Z, Zhang X
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119864
Biochimica et biophysica acta. Molecular cell research 2025 Jan;1872(1):119864
Trametinib and M17, a novel small molecule inhibitor of AKT, display a synergistic antitumor effect in triple negative breast cancer cells through the AKT/mTOR and MEK/ERK pathways.
Han H, Yang M, Wen Z, Mei F, Chen Q, Ma Y, Lai X, Zhang Y, Fang R, Yin T, Sun S, Wang X, Qi J, Lin H, Yang Y
Bioorganic chemistry 2025 Jan;154:107981
Bioorganic chemistry 2025 Jan;154:107981
Shen Zhi Ling oral liquid improve neuroinflammation against Alzheimer's disease via the PI3K/Akt pathway.
Qin G, Cui W, Song R
3 Biotech 2025 Jan;15(1):29
3 Biotech 2025 Jan;15(1):29
Investigating the therapeutic effects of Shenzhiling oral liquid on Alzheimer's disease: a network pharmacology and experimental approach.
Qin G, Song R, Sun J, Chen B, Liu Z, Han L, Sun B, Li C
3 Biotech 2025 Jan;15(1):14
3 Biotech 2025 Jan;15(1):14
Transplantation of engineered endothelial progenitor cells with H19 overexpression promotes arterial reendothelialization and inhibits neointimal hyperplasia.
Ye Y, Huang L, Wang K, Sun Y, Zhou Z, Deng T, Liu Y, Wang R, Wu R, Yao C
Journal of tissue engineering 2025 Jan-Dec;16:20417314251315959
Journal of tissue engineering 2025 Jan-Dec;16:20417314251315959
Homoharringtonine Added to Venetoclax and Azacitidine Improves Outcome and Mitigates Genetic Impact in Relapsed/Refractory AML: A Multicenter Cohort Study.
Yu G, Zhang Y, Yu S, Yin Z, Weng G, Xu N, Du X, Lin D, Xiao J, Sun Z, Zhang H, Liang X, Guo Z, Zhao W, Dai M, Fan Z, Xuan L, Liu H, Xu D, Ye J, Jiang X, Shi P, Jin H, Liu Q
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Jan 6;31(1):87-97
Clinical cancer research : an official journal of the American Association for Cancer Research 2025 Jan 6;31(1):87-97
HSF1 and CPSF1 affect milk fat and protein synthesis by regulating the AKT/mTOR signaling pathway.
Chen Z, Zhang X, Teng J, Jiang L, Zhang Q
Journal of animal science 2025 Jan 4;103
Journal of animal science 2025 Jan 4;103
MYBL2 promotes proliferation of clear cell renal cell carcinoma by regulating TOP2A and activating AKT/mTOR signaling pathway.
Huang Y, Xi X, Ye Z, Zhang C, Jiang Y, Yu F, Huang G
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70330
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Jan 31;39(2):e70330
Network pharmacology, transcriptomics, and biological validation reveal a lipid secretion inhibitory and anti-inflammatory mechanism of tanreqing gel in the treatment of acne.
Ren X, Zhou N, Li D, Li L, Wang Y, Li L, Ma Y, Gao X, Zhao Y, Sun Y, Wang Y
Journal of ethnopharmacology 2025 Jan 31;340:119278
Journal of ethnopharmacology 2025 Jan 31;340:119278
Integrative multi-omics and network pharmacology reveal the mechanisms of Fangji Huangqi Decoction in treating IgA nephropathy.
Liu T, Zhuang XX, Zheng WJ, Gao JR
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118996
Journal of ethnopharmacology 2025 Jan 30;337(Pt 3):118996
Bie Jia Jian pill ameliorates BDL-induced cholestatic hepatic fibrosis in rats by regulating intestinal microbial composition and TMAO-mediated PI3K/AKT signaling pathway.
Cui X, Zhang R, Li Y, Li P, Liu Y, Yu X, Zhou J, Wang L, Tian X, Li H, Zhang S, Lan T, Li X, Zhang G, Li J, Liu Z
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118910
Journal of ethnopharmacology 2025 Jan 30;337(Pt 2):118910
Therapeutic potential of simvastatin in ALS: Enhanced axonal integrity and motor neuron survival through Apoa4 and Alb modulation.
Luo S, Wang X, Ma B, Liu D, Li L, Wang L, Ding N, Zou L, Wang J, Pan J, Sang D, Zhou H, Qu H, Lu Y, Yang L
Biomolecules & biomedicine 2025 Jan 30;25(3):632-647
Biomolecules & biomedicine 2025 Jan 30;25(3):632-647
GLP-1/GIP dual agonist tirzepatide normalizes diabetic nephropathy via PI3K/AKT mediated suppression of oxidative stress.
Tian Y, Tian R, Juan H, Guo Y, Yan P, Cheng Y, Li R, Wang B
International immunopharmacology 2025 Jan 27;146:113877
International immunopharmacology 2025 Jan 27;146:113877
Downregulation of the PI3K/AKT/mTOR/MMP-13 pathway for promoting interface healing via lubricating microspheres.
Yao S, Yuan H, Yang L, Zhang Y, Wang H, Li R, Ye T, Cui W, Wang L
Acta biomaterialia 2025 Jan 24;193:291-304
Acta biomaterialia 2025 Jan 24;193:291-304
The direct and indirect inhibition of proinflammatory adipose tissue macrophages by acarbose in diet-induced obesity.
Li X, Zheng S, Xu H, Zhang Z, Han X, Wei Y, Jin H, Du X, Xu H, Li M, Zhang Z, Wang S, Sun G, Zhang D
Cell reports. Medicine 2025 Jan 21;6(1):101883
Cell reports. Medicine 2025 Jan 21;6(1):101883
Multiomics analysis reveals the involvement of NET1 in tumour immune regulation and malignant progression.
Pang J, Huang X, Gao Y, Guan X, Xiong L, Li L, Yin N, Dai M, Han T, Yi W
Scientific reports 2025 Jan 2;15(1):56
Scientific reports 2025 Jan 2;15(1):56
Chimeric antigen receptor with novel intracellular modules improves antitumor performance of T cells.
Wang P, Wang Y, Zhao X, Zheng R, Zhang Y, Meng R, Dong H, Liang S, He X, Song Y, Su H, Yan B, Yang AG, Jia L
Signal transduction and targeted therapy 2025 Jan 15;10(1):20
Signal transduction and targeted therapy 2025 Jan 15;10(1):20
Maternal exposure to polystyrene nanoplastics during gestation and lactation caused fertility decline in female mouse offspring.
Cheng X, Xue Y, Wang H, Ma Z, Hu N, Zhang C, Gao Y, Fan R, Hu L, Li J, Zhang D, Huang J, Fang S, Xiao R, He Y, Luo T, Zheng L
Ecotoxicology and environmental safety 2025 Jan 1;289:117632
Ecotoxicology and environmental safety 2025 Jan 1;289:117632
Integrating Network Pharmacology and In Vitro Experimental Verification Revealing Bushenhuoxue Recipe Against Intrauterine Adhesions via PI3K-AKT Signaling Pathway.
Wang L, Zhuang L, Lu Y, Jia J, Chen C, Zhang Y, Hong Z, Wang X
Biochemical genetics 2025 Feb;63(1):686-697
Biochemical genetics 2025 Feb;63(1):686-697
SHCBP1 promotes cisplatin resistance of ovarian cancer through AKT/mTOR/Autophagy pathway.
Qi G, Ma H, Teng K, Gai P, Gong Y, Chen J, Luo X, Kong B
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):83-98
Apoptosis : an international journal on programmed cell death 2025 Feb;30(1-2):83-98
Network pharmacology and molecular docking reveal the mechanism of action of Bergapten against non‑small cell lung cancer.
Chen Y, Fu Y, Zou H, Wang P, Xu Y, Xie Q
Oncology letters 2025 Feb;29(2):87
Oncology letters 2025 Feb;29(2):87
α-arbutin prevents UVA-induced skin photodamage via alleviating DNA damage and collagen degradation in NIH-3T3 cells.
Zhao N, Nie X, Yan Y, Liu Z, Chen X, Shu P, Zhong J
Journal of photochemistry and photobiology. B, Biology 2025 Feb;263:113100
Journal of photochemistry and photobiology. B, Biology 2025 Feb;263:113100
Non-starch polysaccharides from Castanea mollissima Bl. ameliorate metabolic syndrome by remodeling barrier function, microbial community, and metabolites in high-fat-diet/streptozotocin-induced diabetic mice.
Peng F, Yu Z, Du B, Niu K, Yu X, Wang S, Yang Y
Food research international (Ottawa, Ont.) 2025 Feb;202:115638
Food research international (Ottawa, Ont.) 2025 Feb;202:115638
Cis-Regulation of an m(6)A Eraser by an Insertion Variant Associated with Survival of Patients With Non-Small Cell Lung Carcinoma.
Cheng L, Hu Q, Wang Y, Nie W, Lu H, Zhang B, Zhao G, Ding S, Pan F, Shen Y, Zhong R, Zhang R
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407652
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Feb;12(5):e2407652
TMEM45A enhances palbociclib resistance and cellular glycolysis by activating AKT/mTOR signaling pathway in HR+ breast cancer.
Chen C, Chen Z, Zhao J, Wen X, Yao H, Weng Z, Xiong H, Zheng Z, Wu J
Cell death discovery 2025 Feb 5;11(1):47
Cell death discovery 2025 Feb 5;11(1):47
Meteorin-like alleviates hepatic steatosis by regulating hepatic triglyceride secretion and fatty acid oxidation.
Song L, Huang Y, Liu L, Chang X, Hu L, Wang G, Xu L, Zhang T, Wang Y, Xiao Y, Yang H, Ran S, Shi Q, Wang T, Shi M, Zhou Y, Guo B
Cell reports 2025 Feb 25;44(2):115246
Cell reports 2025 Feb 25;44(2):115246
Targeting NLRC5 in cardiomyocytes protects postinfarction cardiac injury by enhancing autophagy flux through the CAVIN1/CAV1 axis.
Gu L, Wang S, Zhou L, Wang W, Bao Y, He Y, Yang T, Sun J, Jiang Q, Shan T, Du C, Wang Z, Wang H, Xie L, Gu A, Zhao Y, Ji Y, Wang Q, Wang L
Communications biology 2025 Feb 23;8(1):292
Communications biology 2025 Feb 23;8(1):292
Orally Administrated Precision Nanomedicine for Restoring the Intestinal Barrier and Alleviating Inflammation in Treatment of Inflammatory Bowel Disease.
Wang D, Jiang Q, Li P, Yu C, Yuan R, Dong Z, Meng T, Hu F, Wang J, Yuan H
ACS applied materials & interfaces 2025 Feb 19;17(7):10986-11001
ACS applied materials & interfaces 2025 Feb 19;17(7):10986-11001
Metformin inhibits the growth of SCLC cells by inducing autophagy and apoptosis via the suppression of EGFR and AKT signalling.
Xia H, Tai XJ, Cheng W, Wu Y, He D, Wang LF, Liu H, Zhang SY, Sun YT, Liu HZ, Liu DD, Zhao HZ, Ji FY, Li XH
Scientific reports 2025 Feb 19;15(1):6081
Scientific reports 2025 Feb 19;15(1):6081
Cordycepin ameliorates spaceflight-induced osteoporosis by preventing BMSCs oxidative stress and senescence via interacting with PI3K p110α and regulating PI3K/Akt/FOXO3 signalling.
Zhai Y, Zhang Y, Xu K, Wang T, Zhiqun Bian, Qu L, Wu F, Hu Z, Chang X, Li H, Zhang C, Li C, Shi C
Free radical biology & medicine 2025 Feb 16;228:108-125
Free radical biology & medicine 2025 Feb 16;228:108-125
MAZ regulates ferroptosis, apoptosis and differentiation of oligodendrocyte precursor cells.
Jing F, Wang Q, Xu Y, Dong J, Huang H, Li Y
Brain research 2025 Feb 15;1849:149349
Brain research 2025 Feb 15;1849:149349
Dihydroartemisinin inhibits EphA2/PI3K/Akt pathway-mediated malignant behaviors and vasculogenic mimicry in glioma stem cells.
Fu H, Wu S, Shen H, Luo K, Huang Z, Lu N, Li Y, Lan Q, Xian Y
Heliyon 2025 Feb 15;11(3):e42095
Heliyon 2025 Feb 15;11(3):e42095
Tooth Loss-Induced Gut Dysbiosis Promotes Neuroinflammation via L-Asparagine-Mediated Neuronal Toxicity.
Ji Z, Liu S, Tian Z, Guo N, Wei W, Jiang Q
International dental journal 2025 Dec;75(6):103929
International dental journal 2025 Dec;75(6):103929
KSQ-4279, an Inhibitor of Ubiquitin Specific Peptidase 1, Enhanced the Chemotherapeutic Efficacy in ABCB1/ABCG2/ABCC1-Mediated Multidrug Resistant Cancers.
Yang Q, Luo K, To KKW, Pan C, Fu K, Zhu S, Li S, Wang F, Wu C, Fu L
MedComm 2025 Dec;6(12):e70517
MedComm 2025 Dec;6(12):e70517
Network pharmacology combined with experiments to explore the molecular mechanism of Jiawei Erzhi pill protects against atherosclerosis by inhibiting ferroptosis.
Guiping MA, Ran C, Junlong LI, Le S, Shiping HU, Yiyi Z, Chuangxiong H
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1330-1341
Journal of traditional Chinese medicine = Chung i tsa chih ying wen pan 2025 Dec;45(6):1330-1341
The role and mechanism of autophagy-regulated Keap1/Nrf2 pathway in oxidative stress-induced cartilage endplate cell apoptosis.
Wang W, Deng K, Chen W, Du L, Chen J
Cellular signalling 2025 Dec;136:112153
Cellular signalling 2025 Dec;136:112153
HMBOX1 plays a critical role in plumbagin-induced growth inhibition of hepatocellular carcinoma cells.
Wei Y, Cheng T, Liu H, Ma Y, Liu H, Du Y, Deng S
Scientific reports 2025 Dec 24;16(1):3909
Scientific reports 2025 Dec 24;16(1):3909
Exploring the Protective Effect of Gastrodia elata Extract on D-Galactose-Induced Liver Injury in Mice Based on the PI3K/Akt Signaling Pathway.
Han L, Zhai H, Ma X, Li H, Ren Q, Liu J, Zhang Z, Li X, Zhang Q, Sun X
Current issues in molecular biology 2025 Dec 20;48(1)
Current issues in molecular biology 2025 Dec 20;48(1)
Protective Effects of Arecoline on LPS-Induced Neuroinflammation in BV2 Microglial Cells.
Zhang X, Cui J, Sun J, Fan B, Wang F, Lu C
International journal of molecular sciences 2025 Dec 16;26(24)
International journal of molecular sciences 2025 Dec 16;26(24)
Inhibition of ALOX5-dependent ferroptosis by 6-C-methylquercetin: a potential therapeutic approach for alleviating rheumatoid arthritis.
Jia B, Zhou S, Liu M, Zhang M, Jiang X, Guo X, Bi Y
Free radical biology & medicine 2025 Dec 1;240:153-169
Free radical biology & medicine 2025 Dec 1;240:153-169
Integrated stress response activation induced by usnic acid alleviates BCL-2 inhibitor ABT-199 resistance in acute myeloid leukemia.
Wu D, Li M, Hong Y, Jin L, Liu Q, Sun C, Li L, Han X, Deng S, Feng Y, Shen Y, Kai G
Journal of advanced research 2025 Aug;74:621-635
Journal of advanced research 2025 Aug;74:621-635
Epigallocatechin-3-Gallate Attenuates Benign Prostatic Hyperplasia Development via Regulating Firmicutes to Inhibit Gastric Secretion of Insulin-Like Growth Factor-1.
Yang T, Shao Y, Wang Z, Liu C, Gu M
Cell biology international 2025 Aug;49(8):952-964
Cell biology international 2025 Aug;49(8):952-964
A natural flavagline derivative A2073 inhibits the proliferation of erythroleukemia cells by targeting the MAPK, PI3K, NF-κB, and cell cycle pathways.
Zhou M, Yuan CM, He ZX, Long MT, He LT, Yang Y, Zhang FL, Yang CX, Chen D, Huang MJ, Zhou MX, Wu XJ, Li YM, Yang XY
Bioorganic chemistry 2025 Aug;163:108612
Bioorganic chemistry 2025 Aug;163:108612
Analysis of hepatitis B virus integration identifies KMT2B as a novel cancer-related gene in pancreatic cancer.
Li M, Li H, Liu D, Liu S, Yuan H, Wu Y, Du M, Fang Y, Li J, Cong H, Zhao D, Fan C, Wang Q, Shen C, Gan Y, Sun Y, Tu H
Clinical and translational medicine 2025 Aug;15(8):e70424
Clinical and translational medicine 2025 Aug;15(8):e70424
QSOX2-Mediated Disulfide Bond Modification Enhances Tumor Stemness and Chemoresistance by Activating TSC2/mTOR/c-Myc Feedback Loop in Esophageal Squamous Cell Carcinoma.
Chen WM, Zhang XP, Sun X, Liu HC, Yan YY, Wei X, Liang Y, Feng Y, Chen Z, Jia Y, Jiang C, Yan Q, Li L
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e00597
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Aug;12(31):e00597
p53 Modulates the Gut-Liver Axis via PI3K/AKT/Wnt Signaling Pathways in Type 2 Diabetes.
Li Q, Zhang L, Sun Y, Du Z, Xu S, Wang X, Wei S, Tao Y, Li B, Jiang J, Di G, Huang Y, Xu Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70898
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2025 Aug 31;39(16):e70898
Tumor-derived exosomal tsRNA 3'tiRNA-AlaCGC in promoting fibroblast senescence and Galectin-9 secretion to induce immune tolerance in lung adenocarcinoma.
Zhao G, Zhang Y, Zhang H, Guo Y, Xu C, Ge D, Gu J
Cell death discovery 2025 Aug 25;11(1):403
Cell death discovery 2025 Aug 25;11(1):403
Osteopontin derived from hypoxia-induced M2 macrophages promotes osteosarcoma progression through modulation of EGR3/ISG15 signaling and RIG-I expression.
Xing C, Hu W, Zhao L
Journal of translational medicine 2025 Aug 21;23(1):950
Journal of translational medicine 2025 Aug 21;23(1):950
Single-cell transcriptome analysis identifies MIF as a novel tumor-associated neutrophil marker for pancreatic ductal adenocarcinoma.
Zeng Y, Yu J, Chen Y, Zhuang J, Liang X, Li Y, Chen S, Pang W, Zeng L
NPJ precision oncology 2025 Aug 20;9(1):293
NPJ precision oncology 2025 Aug 20;9(1):293
hUC-MSCs and derived exosomes attenuate DEX-induced muscle atrophy through modulation of estrogen signaling pathway.
Li N, Liu X, Wang Q, Chen Y, Han C, Qu C, Guan X, Zou W, Wang X, Li A, Zhang Y, Zhu L, Du R, Liu J, Wang Y
Stem cell research & therapy 2025 Aug 2;16(1):419
Stem cell research & therapy 2025 Aug 2;16(1):419
Activation of transient receptor potential vanilloid 4 impairs long-term depression in nucleus accumbens and induces depressive-like behavior.
Li K, Liu L, Zhang G, Wang X, Gu T, Luo Q, Sha S, Du Y, Wu C, Chen L
Neuropharmacology 2025 Aug 1;273:110429
Neuropharmacology 2025 Aug 1;273:110429
Hua Yu Xiao Zheng decoction induces ectopic endometrial stromal cell senescence via inhibiting the PI3K/AKT signaling.
Xu Y, Li Y, Zhang J, Cai P
Tissue & cell 2025 Apr;93:102763
Tissue & cell 2025 Apr;93:102763
Electroacupuncture alleviates insulin resistance and impacts the hypothalamic IRS-1/PI3K/AKT pathway and miRNA-29a-3p in a rat model of type 2 diabetes.
Zhuang S, Liu S, Li R, Duan H
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):104-113
Acupuncture in medicine : journal of the British Medical Acupuncture Society 2025 Apr;43(2):104-113
Heliox alleviates ischemia-reperfusion-induced damage to neuronal cells by repressing the USP46-SNX5 Axis-triggered ferroptosis.
Yang H, Wang Z, Xiong W, Zhou L, Yu S
Experimental neurology 2025 Apr;386:115175
Experimental neurology 2025 Apr;386:115175
Sustained release of miR-21 carried by mesenchymal stem cell-derived exosomes from GelMA microspheres inhibits ovarian granulosa cell apoptosis in premature ovarian insufficiency.
Zhang X, Ma L, Liu X, Zhou X, Wang A, Lai Y, Zhang J, Li Y, Chen S
Materials today. Bio 2025 Apr;31:101469
Materials today. Bio 2025 Apr;31:101469
Proteomic Analysis of Human Follicular Fluid-Derived Exosomes Reveals That Insufficient Folliculogenesis in Aging Women is Associated With Infertility.
Liu Z, Zhou Q, Zan J, Tian J, Zhang Y, Wu F, Zhao H, Peng Q, Liu S, Chen Q, Liu E, Liao Z, Zou P, Mei L, Wang W, Dong S, Niu L, Wu S, He L, Zhou X, Jin Y, Li P, Yang S
Molecular & cellular proteomics : MCP 2025 Apr;24(4):100930
Molecular & cellular proteomics : MCP 2025 Apr;24(4):100930
p16(INK4a) Aggravated Sepsis-associated Cardiac Injury by Inhibiting the PI3K/AKT Pathway and Inducing Redox Imbalance.
Li B, Wang K, Wang X, Zhang Z, Huang G, Ma Y, Du Y, Gu X, Hui J
Journal of cardiovascular translational research 2025 Apr;18(2):375-391
Journal of cardiovascular translational research 2025 Apr;18(2):375-391
Accumulation of Damaging Lipids in the Arf1-Ablated Neurons Promotes Neurodegeneration through Releasing mtDNA and Activating Inflammatory Pathways in Microglia.
Li X, Jin S, Wang D, Wu Y, Tang X, Liu Y, Yao T, Han S, Sun L, Wang Y, Hou SX
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Apr;12(16):e2414260
Electroacupuncture modulates the gut-brain axis via the PI3K/Akt pathway to improve feeding behavior, body weight, glucolipid metabolism, and reduce insulin resistance in T2DM rats.
Liu S, Zhuang S, Li R, Duan H
Diabetology & metabolic syndrome 2025 Apr 9;17(1):122
Diabetology & metabolic syndrome 2025 Apr 9;17(1):122
Comparison of the effects between catalase and superoxide dismutase on regulating macrophage inflammatory response and protecting osteogenic function of periodontal ligament cells.
Zhu B, Song L, Li M, Cheng M, Tang W, Miao L
Biochemical and biophysical research communications 2025 Apr 5;756:151523
Biochemical and biophysical research communications 2025 Apr 5;756:151523
Garcinol promotes wound healing in diabetic mice by regulating inflammation and NLRP3 inflammasome-mediated pyroptosis via the PI3K/Akt/NF-κB pathway.
Li Z, Lin K, Wang Y, Mao J, Yin Y, Li Z, Wang F, Zeng X, Li Q, Wang X, Li Z, Miao R, Lin C, Mao C
International immunopharmacology 2025 Apr 4;151:114352
International immunopharmacology 2025 Apr 4;151:114352
Comprehensive analysis illustrating the role of HOXB8 in head and neck squamous cell carcinoma: evidence from multi-omics analysis and experiments validation.
Zhang JW, Gao XL, Wang J, Fan XL, Liang QW
BMC cancer 2025 Apr 30;25(1):804
BMC cancer 2025 Apr 30;25(1):804
Alleviating vascular calcification with Bushen Huoxue formula in rats with chronic kidney disease by inhibiting the PTEN/PI3K/AKT signaling pathway through exosomal microRNA-32.
Guo X, Liu S, Wu X, Yang R, Ren Q, Zhou Y, Shi K, Yuan L, Zhang N, Liu S
The Journal of pharmacy and pharmacology 2025 Apr 3;77(4):550-563
The Journal of pharmacy and pharmacology 2025 Apr 3;77(4):550-563
HNF4α-Mediated LINC02560 Promotes Papillary Thyroid Carcinoma Progression by Targeting the miR-505-5p/PDE4C Axis.
Su Y, Xu B, Gao C, Pei W, Ma M, Zhang W, Hu T, Zhang F, Zhang S
Biomolecules 2025 Apr 28;15(5)
Biomolecules 2025 Apr 28;15(5)
Tanshinone IIA alleviates tri-ortho-cresyl phosphate-induced ovarian damage through Hippo signaling pathway activation in mice.
Ma Z, Hu N, Zheng L, Xue Y, Zhou C, Wang W, Cheng X, Luo T, Yu J, Hu L
Journal of ovarian research 2025 Apr 26;18(1):85
Journal of ovarian research 2025 Apr 26;18(1):85
Integrating metabolomics and network pharmacology to study the mechanism of Er-Xian decoction in improving intervertebral disc degeneration.
Wang X, Ren G, Chen B
Journal of ethnopharmacology 2025 Apr 25;346:119702
Journal of ethnopharmacology 2025 Apr 25;346:119702
Trelagliptin Ameliorates Memory Decline in Diabetic Rats through the AMPK/AKT/GSK-3β Pathway in the Cerebral Cortex.
Yao Y, Shu T, Guo X, Huang J, Chen Q, Liu X, Ouyang C, Yang X, Lei M
ACS omega 2025 Apr 22;10(15):15673-15680
ACS omega 2025 Apr 22;10(15):15673-15680
Role of Quercetin in Modulating Inflammation and Epigenetic Regulation of Staphylococcus aureus-Induced Bovine Mastitis.
Shi Z, Wang W, Shokrollahi B, Wang W, Abdel-Shafy H, Deng T
Journal of agricultural and food chemistry 2025 Apr 16;73(15):8784-8797
Journal of agricultural and food chemistry 2025 Apr 16;73(15):8784-8797
Troxerutin suppresses the stemness of osteosarcoma via the CD155/SRC/β-catenin signaling axis.
Chen J, Li H, Jin Q, Li X, Zhang Y, Shen J, Huang G, Yin J, Zou C, Li X, He X, Xie X, Lin T
Cellular & molecular biology letters 2025 Apr 11;30(1):45
Cellular & molecular biology letters 2025 Apr 11;30(1):45
The Mechanism of Action and Experimental Verification of Narenmandula in the Treatment of Postmenopausal Osteoporosis.
Xiao J, Yu Z, Han Q, Guo Y, Ye J, Lian H, Wang L, Ma Y, Liu M
Combinatorial chemistry & high throughput screening 2024;27(15):2249-2259
Combinatorial chemistry & high throughput screening 2024;27(15):2249-2259
Network Analysis and Basic Experiments on the Inhibition of Renal Cancer Proliferation and Migration by Alpinetin through PI3K/AKT/ mTOR Pathway.
Guo Y, Jiang L, Luo S, Hu D, Zhao X, Zhao G, Tang W
Current molecular medicine 2024;24(1):134-144
Current molecular medicine 2024;24(1):134-144
Endothelial Cell-Derived Exosomes Inhibit Osteoblast Apoptosis and Steroid-Induced Necrosis of Femoral Head Progression by Activating the PI3K/Akt/Bcl-2 Pathway.
Sun J, Yao C, Luo W, Ge X, Zheng W, Sun C, Zhang Y
Journal of tissue engineering and regenerative medicine 2024;2024:3870988
Journal of tissue engineering and regenerative medicine 2024;2024:3870988
HSPD1 Supports Osteosarcoma Progression through Stabilizing ATP5A1 and thus Activation of AKT/mTOR Signaling.
Zhang Y, Pan R, Li K, Cheang LH, Zhao J, Zhong Z, Li S, Wang J, Zhang X, Cheng Y, Zheng X, He R, Wang H
International journal of biological sciences 2024;20(13):5162-5190
International journal of biological sciences 2024;20(13):5162-5190
Exosomal SLC16A1-AS1-induced M2 macrophages polarization facilitates hepatocellular carcinoma progression.
Hu Y, Li Y, Xiong H, Zhang Y, Wang F, Zhuo W, Zeng Z, Zhao Y, Wang H, Hu P, Han S, Huang Y, Lv G, Zhao G
International journal of biological sciences 2024;20(11):4341-4363
International journal of biological sciences 2024;20(11):4341-4363
Chronic intermittent hypoxia aggravated diabetic cardiomyopathy through LKB1/AMPK/Nrf2 signaling pathway.
Liu B, Si J, Qi K, Li D, Li T, Tang Y, Ji E, Yang S
PloS one 2024;19(3):e0296792
PloS one 2024;19(3):e0296792
Electroacupuncture on GB acupoints improves osteoporosis via the estradiol-PI3K-Akt signaling pathway.
Wang X, Zeng X, Long Y, Du Y, Li C, Jiang H, Li G
Open life sciences 2024;19(1):20220978
Open life sciences 2024;19(1):20220978
LARP1 knockdown inhibits cultured gastric carcinoma cell cycle progression and metastatic behavior.
Liu X, Zhang WM, Meng N, Lin LJ, Tang GD
Open life sciences 2024;19(1):20220806
Open life sciences 2024;19(1):20220806
Cold Exposure Alleviates T2DM Through Plasma-Derived Extracellular Vesicles.
Li FX, Xu F, Li CC, Lei LM, Shan SK, Zheng MH, Lin X, Guo B, Tang KX, Duan JY, Wu YY, Cao YC, Liu JJ, Yuan LQ
International journal of nanomedicine 2024;19:10077-10095
International journal of nanomedicine 2024;19:10077-10095
Unveiling the Renoprotective Mechanisms of Schisandrin B in Ischemia-Reperfusion Injury Through Transcriptomic and Pharmacological Analysis.
Xu C, Deng Y, Man J, Wang H, Che T, Ding L, Yang L
Drug design, development and therapy 2024;18:4241-4256
Drug design, development and therapy 2024;18:4241-4256
Unveiling the Therapeutic Potential of Berberine in Rheumatoid Arthritis: A Comprehensive Study of Network Pharmacology, Metabolomics, and Intestinal Flora.
Li B, Liu J, He C, Deng Z, Zhou X, Peng R
Journal of inflammation research 2024;17:10849-10869
Journal of inflammation research 2024;17:10849-10869
Ligustrazine alleviates spinal cord injury-induced neuropathic pain by inhibiting the TLR4/NF-κB signaling pathway.
Jin H, He Y, Liu T, Yang T, Sun X, Chen Y, Shen F
American journal of translational research 2024;16(8):3557-3571
American journal of translational research 2024;16(8):3557-3571
KRT80 Promotes Lung Adenocarcinoma Progression and Serves as a Substrate for VCP.
Huang S, Tong W, Yang B, Ma L, Zhang J, Wang C, Xu L, Mei J
Journal of Cancer 2024;15(8):2229-2244
Journal of Cancer 2024;15(8):2229-2244
Integrated UPLC-ESI-MS/MS, network pharmacology, and transcriptomics to reveal the material basis and mechanism of Schisandra chinensis Fruit Mixture against diabetic nephropathy.
Deng YY, Ma XY, He PF, Luo Z, Tian N, Dong SN, Zhang S, Pan J, Miao PW, Liu XJ, Chen C, Zhu PY, Pang B, Wang J, Zheng LY, Zhang XK, Zhang MY, Zhang MZ
Frontiers in immunology 2024;15:1526465
Frontiers in immunology 2024;15:1526465
Shensu IV maintains the integrity of the glomerular filtration barrier and exerts renal protective effects by regulating endogenous hydrogen sulfide levels.
Zhou S, Zheng L, Zheng T, Zhan H, Lin Q, Wei J, Huang Y
Frontiers in pharmacology 2024;15:1447249
Frontiers in pharmacology 2024;15:1447249
KIF11 promotes vascular smooth muscle cell proliferation by regulating cell cycle progression and accelerates neointimal formation after arterial injury in mice.
Wang G, Zhao P, Yin C, Zheng X, Xie Y, Li X, Shang D, Shao S, Chen H, Wei L, Song Z
Frontiers in pharmacology 2024;15:1392352
Frontiers in pharmacology 2024;15:1392352
Enhanced amphiregulin exposure promotes modulation of the high grade serous ovarian cancer tumor immune microenvironment.
Ebott J, McAdams J, Kim C, Jansen C, Woodman M, De La Cruz P, Schrol C, Ribeiro J, James N
Frontiers in pharmacology 2024;15:1375421
Frontiers in pharmacology 2024;15:1375421
Endosome-microautophagy targeting chimera (eMIATAC) for targeted proteins degradation and enhance CAR-T cell anti-tumor therapy.
Lei K, Li J, Tu Z, Gong C, Liu J, Luo M, Ai W, Wu L, Li Y, Zhou Z, Chen Z, Lv S, Ye M, Wu M, Long X, Zhu X, Huang K
Theranostics 2024;14(11):4481-4498
Theranostics 2024;14(11):4481-4498
Lipopolysaccharide in Bile Promotes the Neutrophil Extracellular Traps-Induced Gallstone Formation by Activating the Gallbladder Immune Barrier.
Yu J, Meng Z, Liu X, Zheng Y, Xue D, Hao C, Wang L
ImmunoTargets and therapy 2024;13:789-803
ImmunoTargets and therapy 2024;13:789-803
Acromegalic Rat Model Presented Cognitive Impairments and Tau Hyperphosphorylation in the Hippocampus.
Chen J, Xiang Z, Zhang Z, Yang Y, Shu K, Lei T
Neuroendocrinology 2024;114(6):577-588
Neuroendocrinology 2024;114(6):577-588
ABT‑737 increases cisplatin sensitivity through the ROS‑ASK1‑JNK MAPK signaling axis in human ovarian cancer cisplatin‑resistant A2780/DDP cells.
Li X, Guo Y, Xing Z, Gong T, Yang L, Yang T, Chang B, Wang X, Yu B, Guo R
Oncology reports 2024 Sep;52(3)
Oncology reports 2024 Sep;52(3)
Effects of catechin on the malignant biological behavior of gastric cancer cells through the PI3K/Akt signaling pathway.
Ding Y, Li H, Cao S, Yu Y
Toxicology and applied pharmacology 2024 Sep;490:117036
Toxicology and applied pharmacology 2024 Sep;490:117036
Single-Cell Landscape and a Macrophage Subset Enhancing Brown Adipocyte Function in Diabetes.
Gu J, Jin J, Ren X, Zhang X, Li J, Wang X, Zhang S, Yin X, Zhang Q, Wang Z
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Diabetes & metabolism journal 2024 Sep;48(5):885-900
Anti‑epileptic mechanism of isopimaric acid from Platycladi cacumen based on network pharmacology, molecular docking and biological validation.
Wang Y, Wang Y, Li C, Liu D, Cai Y, Li Q
Experimental and therapeutic medicine 2024 Sep;28(3):348
Experimental and therapeutic medicine 2024 Sep;28(3):348
Nesfatin-1 mitigates calcific aortic valve disease via suppressing ferroptosis mediated by GSH/GPX4 and ZIP8/SOD2 axes.
Wang S, Gu J, Bian J, He Y, Xu X, Wang C, Li G, Zhang H, Ni B, Chen S, Shao Y, Jiang Y
Free radical biology & medicine 2024 Sep;222:149-164
Free radical biology & medicine 2024 Sep;222:149-164
Panax notoginseng saponins dually modulates autophagy in gastric precancerous lesions complicated with myocardial ischemia-reperfusion injury model through the PI3K/AKT/mTOR pathway.
Wang X, Zhang R, Zeng N, Li H, Hua B
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117268
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Sep;178:117268
Icariin alleviates oxygen-induced retinopathy by targeting microglia hexokinase 2.
Li X, Wang G, Li N, Wang X, Fan W, Zhang Z, Li W, Liu J, Huang J, Liu X, Zhou Q, Hou S
Immunology 2024 Sep;173(1):141-151
Immunology 2024 Sep;173(1):141-151
Canthin-6-one analogs block Newcastle disease virus proliferation via suppressing the Akt and ERK pathways.
Wang C, Wang T, Dai J, Han Y, Hu R, Li N, Yang Z, Wang J
Poultry science 2024 Sep;103(9):103944
Poultry science 2024 Sep;103(9):103944
BUB1 induces AKT/mTOR pathway activity to promote EMT induction in human small cell lung cancer.
Wang M, You L, Su Z, He Y, Li D, Liu Z
Scientific reports 2024 Sep 4;14(1):20654
Scientific reports 2024 Sep 4;14(1):20654
A novel PROTAC molecule dBET1 alleviates pathogenesis of experimental autoimmune encephalomyelitis in mice by degrading BRD4.
Song Z, Li J, He Y, Wang X, Tian J, Wu Y
International immunopharmacology 2024 Sep 30;139:112646
International immunopharmacology 2024 Sep 30;139:112646
Clarithromycin attenuates airway epithelial-mesenchymal transition in ovalbumin-induced asthmatic mice through modulation of Kv1.3 channels and PI3K/Akt signaling.
Sun B, Shen K, Zhao R, Li Y, Lin J
International immunopharmacology 2024 Sep 30;139:112624
International immunopharmacology 2024 Sep 30;139:112624
Melatonin alleviates aging-related heart failure through melatonin receptor 1A/B knockout in mice.
Feng Z, Liu Y, Yang Y, Bai J, Lin QY, Xia YL, Xie Y
Heliyon 2024 Sep 30;10(18):e38098
Heliyon 2024 Sep 30;10(18):e38098
Acetate enables metabolic fitness and cognitive performance during sleep disruption.
He Q, Ji L, Wang Y, Zhang Y, Wang H, Wang J, Zhu Q, Xie M, Ou W, Liu J, Tang K, Lu K, Liu Q, Zhou J, Zhao R, Cai X, Li N, Cao Y, Li T
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Cell metabolism 2024 Sep 3;36(9):1998-2014.e15
Reduced syncytin-1 regulates trophoblast invasion and apoptosis in preeclampsia.
Wang YN, Chen XL, Yang J, Gong XX, Zhang HF, Zhang YM, Zeng DF, Chen PS, Chen HB
Placenta 2024 Sep 26;155:32-41
Placenta 2024 Sep 26;155:32-41
Epicatechin and β-Glucan from Whole Highland Barley Grain Synergistic Benefit on Attenuating Hyperglycemia via Improving Hepatic Glucose Metabolism in Diabetic C57BL/6J Mice.
Liu Z, Zhang Z, Tang R, Liu J, Yang Y
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
Journal of agricultural and food chemistry 2024 Sep 18;72(37):20458-20469
FABP4 deficiency ameliorates alcoholic steatohepatitis in mice via inhibition of p53 signaling pathway.
Xing H, Wu Z, Jiang K, Yuan G, Guo Z, Yu S, He S, Zhong F
Scientific reports 2024 Sep 10;14(1):21135
Scientific reports 2024 Sep 10;14(1):21135
Promotion of apoptosis in melanoma cells by taxifolin through the PI3K/AKT signaling pathway: Screening of natural products using WGCNA and CMAP platforms.
Wang Y, Chen SJ, Ma T, Long Q, Chen L, Xu KX, Cao Y
International immunopharmacology 2024 Sep 10;138:112517
International immunopharmacology 2024 Sep 10;138:112517
Matrine inhibits invasion and migration of gallbladder cancer via regulating the PI3K/AKT signaling pathway.
Mo RL, Li Z, Zhang P, Sheng MH, Han GC, Sun DQ
Naunyn-Schmiedeberg's archives of pharmacology 2024 Oct;397(10):8129-8143
Naunyn-Schmiedeberg's archives of pharmacology 2024 Oct;397(10):8129-8143
Plasma-derived exosome miR-10a-5p promotes premature ovarian failure by target BDNF via the TrkB/Akt/mTOR signaling pathway.
Bao Z, Li J, Cai J, Yao S, Yang N, Yang J, Zhao B, Chen Y, Wu X
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
International journal of biological macromolecules 2024 Oct;277(Pt 1):134195
Promoter hypermethylation-induced downregulation of ITGA7 promotes colorectal cancer proliferation and migration by activating the PI3K/AKT/NF-κB pathway.
Wang J, Wang Y, Zhu J, Wang L, Huang Y, Zhang H, Wang X, Li X
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119785
Biochimica et biophysica acta. Molecular cell research 2024 Oct;1871(7):119785
The neuroprotective role of celastrol on hippocampus in diabetic rats by inflammation restraint, insulin signaling adjustment, Aβ reduction and synaptic plasticity alternation.
Zhou Q, Guo X, Chen T, Liu Y, Ji H, Sun Y, Yang X, Ouyang C, Liu X, Lei M
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117397
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Oct;179:117397
Design, synthesis and anticancer activity of β-carboline based pseudo-natural products by inhibiting AKT/mTOR signaling pathway.
Lv L, Song K, Xiao Y, Zheng J, Zhang W, Li L, Wei Y, Chen H, He Y, Guo Z, Nie S
Bioorganic chemistry 2024 Oct;151:107648
Bioorganic chemistry 2024 Oct;151:107648
Inhibition of HOXC11 by artesunate induces ferroptosis and suppresses ovarian cancer progression through transcriptional regulation of the PROM2/PI3K/AKT pathway.
Li J, Feng L, Yuan Y, He T, Zou X, Su B, Liu K, Yang X
World journal of surgical oncology 2024 Oct 8;22(1):268
World journal of surgical oncology 2024 Oct 8;22(1):268
ROCK2 increases drug resistance in acute myeloid leukemia via metabolic reprogramming and MAPK/PI3K/AKT signaling.
Yan M, Luo X, Han H, Qiu J, Ye Q, Zhang L, Wang Y
International immunopharmacology 2024 Oct 25;140:112897
International immunopharmacology 2024 Oct 25;140:112897
Unveiling an anoikis-related risk model and the role of RAD9A in colon cancer.
Yang T, Liu YL, Guo HL, Peng XF, Zhang B, Wang D, Yao HF, Zhang JF, Wang XY, Chen PC, Xu DP
International immunopharmacology 2024 Oct 25;140:112874
International immunopharmacology 2024 Oct 25;140:112874
Astragaloside IV augments anti-PD-1 therapy to suppress tumor growth in lung cancer by remodeling the tumor microenvironment.
Wu T, Wu S, Gao H, Liu H, Feng J, Yin G
European journal of histochemistry : EJH 2024 Oct 23;68(4)
European journal of histochemistry : EJH 2024 Oct 23;68(4)
Nuclear receptor 4A1 ameliorates UUO-induced renal fibrosis by inhibiting the PI3K/AKT pathway.
Wang H, Wei Z, Xu C, Fang F, Wang Z, Zhong Y, Wang X
Scientific reports 2024 Oct 21;14(1):24787
Scientific reports 2024 Oct 21;14(1):24787
Reprograming immunosuppressive microenvironment by eIF4G1 targeting to eradicate pancreatic ductal adenocarcinoma.
He L, Zhang X, Shi F, Zhang H, Chen Y, Sun K, Yang H, Shi J, Lin Z, Lu Q, Wang S, Liu L, Liu X, Meng Q, Huang J, Xu P, Bai X, Liang T
Cell reports. Medicine 2024 Oct 15;5(10):101731
Cell reports. Medicine 2024 Oct 15;5(10):101731
Silica nanoparticles cause ovarian dysfunction and fertility decrease in mice via oxidative stress-activated autophagy and apoptosis.
Liu W, Liu H, Zhang S, Hao H, Meng F, Ma W, Guo Z, Jiang S, Shang X
Ecotoxicology and environmental safety 2024 Oct 15;285:117049
Ecotoxicology and environmental safety 2024 Oct 15;285:117049
Regulation of cervical cancer via G15-mediated inhibition of G protein-coupled estrogen receptor.
Zhu Z, Nie X, Deng L, Ding J, Chen J, Zhu J, Yin X, Guo B, Zhang F
Anti-cancer drugs 2024 Oct 1;35(9):817-829
Anti-cancer drugs 2024 Oct 1;35(9):817-829
Yeast Extract Peptides Alleviate Depression in Chronic Restraint Stress Rats by Alleviating Hippocampal Neuronal Apoptosis and Dysbiosis of the Gut Microbiota.
Zou Z, Xiao N, Chen Z, Lin X, Li Y, Li P, Cheng Q, Du B
Molecular nutrition & food research 2024 Nov;68(21):e2300467
Molecular nutrition & food research 2024 Nov;68(21):e2300467
Targeting serum response factor (SRF) deactivates ΔFosB and mitigates Levodopa-induced dyskinesia in a mouse model of Parkinson's disease.
Kambey PA, Wu J, Liu W, Su M, Buberwa W, Tang C
Gene therapy 2024 Nov;31(11-12):614-624
Gene therapy 2024 Nov;31(11-12):614-624
Schizophyllum commune fruiting body polysaccharides inhibit glioma by mediating ARHI regulation of PI3K/AKT signalling pathway.
Zheng SX, Chen JP, Liang RS, Zhuang BB, Wang CH, Zhang GL, Shi SS, Chen J
International journal of biological macromolecules 2024 Nov;279(Pt 3):135326
International journal of biological macromolecules 2024 Nov;279(Pt 3):135326
Piperlongumine, a natural alkaloid from Piper longum L. ameliorates metabolic-associated fatty liver disease by antagonizing the thromboxane A(2) receptor.
Dai Y, Chen J, Fang J, Liang S, Zhang H, Li H, Chen W
Biochemical pharmacology 2024 Nov;229:116518
Biochemical pharmacology 2024 Nov;229:116518
Cardamonin intervenes in myocardial hypertrophy progression by regulating Usp18.
Feng Z, Pan L, Qiao C, Yang Y, Yang X, Xie Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155970
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Nov;134:155970
Protective effect of folic acid on MNNG-induced proliferation of esophageal epithelial cells via the PI3K/AKT/mTOR signaling pathway.
Cheng S, Chen J, Li Q, Nie Y, Ni T, Peng C, Luo X, Yasin P, Zhang S, Tang J, Liu Z
The Journal of nutritional biochemistry 2024 Nov;133:109702
The Journal of nutritional biochemistry 2024 Nov;133:109702
Co-exposure of polyvinyl chloride microplastics with cadmium promotes nonalcoholic fatty liver disease in female ducks through oxidative stress and glycolipid accumulation.
Chen Y, Jin H, Ali W, Zhuang T, Sun J, Wang T, Song J, Ma Y, Yuan Y, Bian J, Liu Z, Zou H
Poultry science 2024 Nov;103(11):104152
Poultry science 2024 Nov;103(11):104152
Succinic Acid Improves the Metabolism of High-Fat Diet-Induced Mice and Promotes White Adipose Browning.
Yang Y, Luo L, Li Y, Shi X, Li C, Chai J, Jiang S, Zheng R
Nutrients 2024 Nov 8;16(22)
Nutrients 2024 Nov 8;16(22)
Ythdf2 facilitates precursor miR-378/miR-378-5p maturation to support myogenic differentiation.
Deng K, Su Y, Liu Z, Hu S, Ren C, Wei W, Fan Y, Zhang Y, Wang F
Cellular and molecular life sciences : CMLS 2024 Nov 6;81(1):445
Cellular and molecular life sciences : CMLS 2024 Nov 6;81(1):445
DsbA-L activates TGF-β1/SMAD3 signaling and M2 macrophage polarization by stimulating AKT1 and NLRP3 to promote pulmonary fibrosis.
Wang J, Xia Z, Qing B, Chen Y, Gu L, Chen H, Ge Z, Yuan Y
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Molecular medicine (Cambridge, Mass.) 2024 Nov 23;30(1):228
Mechanism of cold exposure delaying wound healing in mice.
Li FX, Liu JJ, Lei LM, Li YH, Xu F, Lin X, Cui RR, Zheng MH, Guo B, Shan SK, Tang KX, Li CC, Wu YY, Duan JY, Cao YC, Wu YL, He SY, Chen X, Wu F, Yuan LQ
Journal of nanobiotechnology 2024 Nov 20;22(1):723
Journal of nanobiotechnology 2024 Nov 20;22(1):723
PXD101 inhibits malignant progression and radioresistance of glioblastoma by upregulating GADD45A.
Hu X, Zhou P, Peng X, Ouyang Y, Li D, Wu X, Yang L
Journal of translational medicine 2024 Nov 20;22(1):1047
Journal of translational medicine 2024 Nov 20;22(1):1047
Catalpol regulates apoptosis and proliferation of endothelial cell via activating HIF-1α/VEGF signaling pathway.
Ni J, Zhang Q, Jiang L, Wang H, Zhang C, Deng J
Scientific reports 2024 Nov 16;14(1):28327
Scientific reports 2024 Nov 16;14(1):28327
Folic Acid Attenuates N-Methyl-N'-Nitro-N-NitrosoguanidineInduced Gastric Mucosal Injury in Rats.
Peng C, Wang L, Liang Y, Che L, Sun R, Yu J, Gong J, Wang D, Cheng S, Yang Q, Jing T, Liu Z
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Nov 1;35(11):839-848
The Turkish journal of gastroenterology : the official journal of Turkish Society of Gastroenterology 2024 Nov 1;35(11):839-848
Inhibition of HIF-2α expression in cardiomyocytes attenuates PCB126-induced cardiotoxicity associated with decreased apoptosis through the PI3K/Akt and p53 signaling pathways.
Chen L, Chen LJ, Shen HW, Hsu C, Zeng JH, Li JH, Liu JL, Yang JZ, Liu Y, Li XW, Xie XL, Wang Q, Zhao D
Ecotoxicology and environmental safety 2024 Nov 1;286:117185
Ecotoxicology and environmental safety 2024 Nov 1;286:117185
2-Ethylhexyl diphenyl phosphate aggravates colitis-induced neuroinflammation and behavioral abnormalities by inhibiting the PI3K-AKT-NF-κB and Wnt/GSK3β signaling pathways.
Hsu C, Zeng JH, Chen L, Chen LJ, Li XW, Yang JZ, Liu Y, Liu JL, Li JH, Li JH, Xie XL, Wang Q
Ecotoxicology and environmental safety 2024 Nov 1;286:117173
Ecotoxicology and environmental safety 2024 Nov 1;286:117173
Sorcin promotes proliferation of hepatocellular carcinoma by regulating VEGFA/B via PI3K pathway.
Zhang H, Hu S, Sanches JGP, Li Y, Wei Y, Pu C, Zhang J
Journal of physiology and biochemistry 2024 May;80(2):381-392
Journal of physiology and biochemistry 2024 May;80(2):381-392
Schisandrin A Alleviates Spatial Learning and Memory Impairment in Diabetic Rats by Inhibiting Inflammatory Response and Through Modulation of the PI3K/AKT Pathway.
Guo X, Lei M, Ma G, Ouyang C, Yang X, Liu C, Chen Q, Liu X
Molecular neurobiology 2024 May;61(5):2514-2529
Molecular neurobiology 2024 May;61(5):2514-2529
CNPY2 governs PDGF‑BB‑treated vascular smooth muscle cell proliferation, migration and phenotypic transformation via the Akt/mTOR/GSK‑3β signaling pathway.
Sun H, Wang X, Ma L, Li X, Jin W, Yang Y
Experimental and therapeutic medicine 2024 May;27(5):197
Experimental and therapeutic medicine 2024 May;27(5):197
HNF1A induces glioblastoma by upregulating EPS8 and activating PI3K/AKT signaling pathway.
Yang G, Su F, Han BX, Su HX, Guo CH, Yu SH, Guan QL, Hou XM
Biochemical pharmacology 2024 May;223:116133
Biochemical pharmacology 2024 May;223:116133
Daurisoline suppress glioma progression by inhibiting autophagy through PI3K/AKT/mTOR pathway and increases TMZ sensitivity.
Yin HT, Hui-Lu, Yang JH, Li Q, Li M, Zhao QQ, Wen ZP
Biochemical pharmacology 2024 May;223:116113
Biochemical pharmacology 2024 May;223:116113
Untargeted metabolomic reveals the changes in muscle metabolites of mice during exercise recovery and the mechanisms of whey protein and whey protein hydrolysate in promoting muscle repair.
Zhao C, Gong Y, Zheng L, Zhao M
Food research international (Ottawa, Ont.) 2024 May;184:114261
Food research international (Ottawa, Ont.) 2024 May;184:114261
Tiliroside disrupted iron homeostasis and induced ferroptosis via directly targeting calpain-2 in pancreatic cancer cells.
Xu M, Zhong W, Yang C, Liu M, Yuan X, Lu T, Li D, Zhang G, Liu H, Zeng Y, Yang X, Zhou Y, Zhou L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 May;127:155392
Patient tissue-derived FGFR4-variant and wild-type colorectal cancer organoid development and anticancer drug sensitivity testing.
Lin H, Fu H, Sun S, Yin H, Yuan J, Liao J
Heliyon 2024 May 30;10(10):e30985
Heliyon 2024 May 30;10(10):e30985
αO-Conotoxin GeXIVA[1,2] Suppresses In Vivo Tumor Growth of Triple-Negative Breast Cancer by Inhibiting AKT-mTOR, STAT3 and NF-κB Signaling Mediated Proliferation and Inducing Apoptosis.
Guo X, He L, Xu W, Wang W, Feng X, Fu Y, Zhang X, Ding RB, Qi X, Bao J, Luo S
Marine drugs 2024 May 29;22(6)
Marine drugs 2024 May 29;22(6)
Hypoxia-induced TREM1 promotes mesenchymal-like states of glioma stem cells via alternatively activating tumor-associated macrophages.
Dong M, Zhang X, Peng P, Chen Z, Zhang Y, Wan L, Xiang W, Liu G, Guo Y, Xiao Q, Wang B, Guo D, Zhu M, Yu X, Wan F
Cancer letters 2024 May 28;590:216801
Cancer letters 2024 May 28;590:216801
BDTX-189, a novel tyrosine kinase inhibitor, inhibits cell activity via ERK and AKT pathways in the EGFR C797S triple mutant cells.
Wang R, Cui W, Li L, Wei X, Chu C, Zhang G, Liu C, Xu H, Liu C, Wang K, Li Y, An L
Chemico-biological interactions 2024 May 25;395:111033
Chemico-biological interactions 2024 May 25;395:111033
Mechanic study based on untargeted metabolomics of Pi-pa-run-fei-tang on pepper combined with ammonia induced chronic cough model mice.
Jie XL, Tong ZR, Xu XY, Wu JH, Jiang XL, Tao Y, Feng PS, Yu J, Lan JP, Wang P
Journal of ethnopharmacology 2024 May 23;326:117905
Journal of ethnopharmacology 2024 May 23;326:117905
Novel miR-490-3p/hnRNPA1-b/PKM2 axis mediates the Warburg effect and proliferation of colon cancer cells via the PI3K/AKT pathway.
Wan XH, Jin GB, Yang Q, Hu JL, Liu ZL, Rao J, Wen C, Li PL, Yang XM, Huang B, Wang XZ
World journal of gastrointestinal oncology 2024 May 15;16(5):2038-2059
World journal of gastrointestinal oncology 2024 May 15;16(5):2038-2059
Dihydroquercetin regulates HIF-1α/AKT/NR2B signalling to improve impaired brain function in rats with metabolic syndrome.
Fu Y, Yuan P, Zeng M, Zhang Q, Hou Y, Gao L, Wei Y, Zheng Y, Feng W, Zheng X
Heliyon 2024 May 15;10(9):e29807
Heliyon 2024 May 15;10(9):e29807
Mechanistic exploration and experimental validation of the Xiaochaihu decoction for the treatment of breast cancer by network pharmacology.
Liu Q, Luo Z, Sun M, Li W, Liu S
Aging 2024 May 13;16(9):7979-7999
Aging 2024 May 13;16(9):7979-7999
Advanced glycation end products promote meniscal calcification by activating the mTOR-ATF4 positive feedback loop.
Yang S, Xie J, Pan Z, Guan H, Tu Y, Ye Y, Huang S, Fu S, Li K, Huang Z, Li X, Shi Z, Li L, Zhang Y
Experimental & molecular medicine 2024 Mar;56(3):630-645
Experimental & molecular medicine 2024 Mar;56(3):630-645
The potential mechanism of ursolic acid in the treatment of bladder cancer based on network pharmacology and molecular docking.
Huang XL, Sun Y, Wen P, Pan JC, He WY
The Journal of international medical research 2024 Mar;52(3):3000605241234006
The Journal of international medical research 2024 Mar;52(3):3000605241234006
Hypothermic machine perfusion reduces donation after circulatory death liver ischemia-reperfusion injury through the SERPINA3-mediated PI3Kδ/Akt pathway.
Peng S, Liang W, Liu Z, Ye S, Peng Z, Zhong Z, Ye Q
Human cell 2024 Mar;37(2):420-434
Human cell 2024 Mar;37(2):420-434
Carrimycin ameliorates lipopolysaccharide and cecal ligation and puncture-induced sepsis in mice.
Lai J, Liang J, Chen K, Guan B, Chen Z, Chen L, Fan J, Zhang Y, Li Q, Su J, Chen Q, Lin J
Chinese journal of natural medicines 2024 Mar;22(3):235-248
Chinese journal of natural medicines 2024 Mar;22(3):235-248
Extracellular vesicle mediated targeting delivery of growth differentiation factor-15 improves myocardial repair by reprogramming macrophages post myocardial injury.
Xiao T, Wei J, Cai D, Wang Y, Cui Z, Chen Q, Gu Q, Zou A, Mao L, Chi B, Ji Y, Wang Q, Sun L
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116224
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Mar;172:116224
Structure-based design and synthesis of anti-fibrotic compounds derived from para-positioned 3,4,5-trisubstituted benzene.
Hong W, Xiao T, Lin G, Liu C, Li H, Li Y, Hu H, Wu S, Wang S, Liang Z, Lin T, Liu J, Chen X
Bioorganic chemistry 2024 Mar;144:107113
Bioorganic chemistry 2024 Mar;144:107113
SP140 inhibitor suppressing TRIM22 expression regulates glioma progress through PI3K/AKT signaling pathway.
Li X, Li G, Li L, Gao B, Niu X, Wang Y, Wang Z
Brain and behavior 2024 Mar;14(3):e3465
Brain and behavior 2024 Mar;14(3):e3465
Mechanisms of vemurafenib-induced anti-tumor effects in ATC FRO cells.
Xu J, Xue D, Li Y, Zhou J, Chen H, Fan L
Heliyon 2024 Mar 30;10(6):e27629
Heliyon 2024 Mar 30;10(6):e27629
Exploring the molecular mechanism of Artemisia rupestris L. for the treatment of hepatocellular carcinoma via PI3K/AKT pathway.
Zhang S, Cai X, Khan GJ, Cheng J, He J, Zhai K, Mao Y
Journal of ethnopharmacology 2024 Mar 25;322:117572
Journal of ethnopharmacology 2024 Mar 25;322:117572
Extracellular vesicles secreted from mesenchymal stem cells ameliorate renal ischemia reperfusion injury by delivering miR-100-5p targeting FKBP5/AKT axis.
Chen G, Li X, Zhou X, Li Y, Yu H, Peng X, Bai X, Zhang C, Feng Z, Mei Y, Li L, Liu Y, Gou X, Jiang Y
Scientific reports 2024 Mar 20;14(1):6720
Scientific reports 2024 Mar 20;14(1):6720
GL-V9 inhibits the activation of AR-AKT-HK2 signaling networks and induces prostate cancer cell apoptosis through mitochondria-mediated mechanism.
Wang R, Min Q, Guo Y, Zhou Y, Zhang X, Wang D, Gao Y, Wei L
iScience 2024 Mar 15;27(3):109246
iScience 2024 Mar 15;27(3):109246
PEBP4 deficiency aggravates LPS-induced acute lung injury and alveolar fluid clearance impairment via modulating PI3K/AKT signaling pathway.
Shi QQ, Huang YH, Li YF, Zhen SY, Li YH, Huang JY, Wang JY, Zhou XY
Cellular and molecular life sciences : CMLS 2024 Mar 13;81(1):133
Cellular and molecular life sciences : CMLS 2024 Mar 13;81(1):133
The mechanism of EGFL7 regulating neovascularization in diabetic retinopathy through the PI3K/AKT/VEGFA pathway.
Xian Y, Wang X, Yu Y, Chen X
Life sciences 2024 Mar 1;340:122483
Life sciences 2024 Mar 1;340:122483
Study on the effect and mechanism of Zhenzhu Tongluo pills in treating diabetic peripheral neuropathy injury.
Dong P, Zhou L, Wang X, Xue L, Du Y, Cui R
European journal of medical research 2024 Mar 1;29(1):149
European journal of medical research 2024 Mar 1;29(1):149
Downregulation of HIGD1B induces mitochondria-mediated apoptosis in gastric cancer cells by inactivating Akt and ERK pathways.
Chen X, Sun B, Li S
Drug development research 2024 Jun;85(4):e22221
Drug development research 2024 Jun;85(4):e22221
Apigetrin alleviates intervertebral disk degeneration by regulating nucleus pulposus cell autophagy.
Xu T, Zhao H, Li J, Fang X, Wu H, Hu W
JOR spine 2024 Jun;7(2):e1325
JOR spine 2024 Jun;7(2):e1325
Licochalcone A alleviates ferroptosis in doxorubicin-induced cardiotoxicity via the PI3K/AKT/MDM2/p53 pathway.
Chen G, Luo S, Guo H, Lin J, Xu S
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4247-4262
Naunyn-Schmiedeberg's archives of pharmacology 2024 Jun;397(6):4247-4262
Kallistatin Improves High-Fat-Induced Insulin Resistance via Epididymal Adipose Tissue-Derived Exosomes.
Yang ZW, Ji JJ, Jiang Y, Wu Y, Guo JQ, Ma GS, Yao YY
Human gene therapy 2024 Jun;35(11-12):388-400
Human gene therapy 2024 Jun;35(11-12):388-400
Thymoquinone affects hypoxia-inducible factor-1α expression in pancreatic cancer cells via HSP90 and PI3K/AKT/mTOR pathways.
Zhao ZX, Li S, Liu LX
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
World journal of gastroenterology 2024 Jun 7;30(21):2793-2816
RNA sequencing screening and gene function analysis uncover G protein-coupled receptor 183 as a key mediator for methionine to stimulate milk synthesis in mouse mammary epithelial cells.
Zhou Y, Fan S, Xu M, Zhang M, Gao X
The British journal of nutrition 2024 Jun 4;:1-13
The British journal of nutrition 2024 Jun 4;:1-13
Extracellular vesicles activated cancer-associated fibroblasts promote lung cancer metastasis through mitophagy and mtDNA transfer.
Zhou Z, Qu C, Zhou P, Zhou Q, Li D, Wu X, Yang L
Journal of experimental & clinical cancer research : CR 2024 Jun 3;43(1):158
Journal of experimental & clinical cancer research : CR 2024 Jun 3;43(1):158
FLT3-selective PROTAC: Enhanced safety and increased synergy with Venetoclax in FLT3-ITD mutated acute myeloid leukemia.
Tan Y, Xin L, Wang Q, Xu R, Tong X, Chen G, Ma L, Yang F, Jiang H, Zhang N, Wu J, Li X, Guo X, Wang C, Zhou H, Zhou F
Cancer letters 2024 Jun 28;592:216933
Cancer letters 2024 Jun 28;592:216933
NAT1 inhibits liver metastasis of colorectal cancer by regulating EMT and glycolysis.
Gu W, Li C, Shen T, Tong L, Yuan W, Zheng X, Wang T, Wang S, Zhu B, Zhang C, Zhang C
Aging 2024 Jun 24;16(12):10546-10562
Aging 2024 Jun 24;16(12):10546-10562
Amiloride reduces fructosamine-3-kinase expression to restore sunitinib sensitivity in renal cell carcinoma.
Bai Y, You Y, Chen D, Chen Y, Yin Z, Liao S, You B, Lu D, Sun Y, Wu L, Wu Y
iScience 2024 Jun 21;27(6):109997
iScience 2024 Jun 21;27(6):109997
Chemotherapy-induced high expression of IL23A enhances efficacy of anti-PD-1 therapy in TNBC by co-activating the PI3K-AKT signaling pathway of CTLs.
Pan F, Liu J, Chen Y, Zhu B, Chen W, Yang Y, Zhu C, Zhao H, Liu X, Xu Y, Xu X, Huo L, Xie L, Wang R, Gu J, Huang G
Scientific reports 2024 Jun 20;14(1):14248
Scientific reports 2024 Jun 20;14(1):14248
CSTF3 contributes to platinum resistance in ovarian cancer through alternative polyadenylation of lncRNA NEAT1 and generating the short isoform NEAT1_1.
Luo X, Wei Q, Jiang X, Chen N, Zuo X, Zhao H, Liu Y, Liu X, Xie L, Yang Y, Liu T, Yi P, Xu J
Cell death & disease 2024 Jun 19;15(6):432
Cell death & disease 2024 Jun 19;15(6):432
Treg and neutrophil extracellular trap interaction contributes to the development of immunosuppression in sepsis.
Shi Y, Wu D, Wang Y, Shao Y, Zeng F, Zhou D, Zhang H, Miao C
JCI insight 2024 Jun 18;9(14)
JCI insight 2024 Jun 18;9(14)
Gold Nanoparticle Delivery of Glut1 SiRNA Facilitates Glucose Starvation Therapy in Lung Cancer.
Li J, Yu J, Fang Q, Du Y, Zhang X
Chembiochem : a European journal of chemical biology 2024 Jun 17;25(12):e202400239
Chembiochem : a European journal of chemical biology 2024 Jun 17;25(12):e202400239
β-elemene promotes microglial M2-like polarization against ischemic stroke via AKT/mTOR signaling axis-mediated autophagy.
Zhao Q, Chen L, Zhang X, Yang H, Li Y, Li P
Chinese medicine 2024 Jun 15;19(1):86
Chinese medicine 2024 Jun 15;19(1):86
BI-2865, a pan-KRAS inhibitor, reverses the P-glycoprotein induced multidrug resistance in vitro and in vivo.
Yang Q, To KKW, Hu G, Fu K, Yang C, Zhu S, Pan C, Wang F, Luo K, Fu L
Cell communication and signaling : CCS 2024 Jun 13;22(1):325
Cell communication and signaling : CCS 2024 Jun 13;22(1):325
The therapeutic effect of ultrasound targeted destruction of schisandrin A contrast microbubbles on liver cancer and its mechanism.
Wang X, Wang F, Dong P, Zhou L
Radiology and oncology 2024 Jun 1;58(2):221-233
Radiology and oncology 2024 Jun 1;58(2):221-233
Identification of bioactive ingredients and potential mechanisms of flowers of Hosta Plantaginea in treating pneumonia based on network pharmacology and experimental validation.
Li Z, Xu Y, Wang Q, Yao M, Zhang H, He M, Li Z, Li H, Feng Y
Fitoterapia 2024 Jul;176:106010
Fitoterapia 2024 Jul;176:106010
Antidiabetic action of the Chinese formula Shouhuitongbian and the underlying mechanism associated with alteration of gut microbiota.
Wang T, Liao H, Lin J, Zhang M, Chen B, Yin R, Sun J, Dai H, Liu H
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155575
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155575
Ginkgetin improved experimental colitis by inhibiting intestinal epithelial cell apoptosis through EGFR/PI3K/AKT signaling.
Geng Z, Zuo L, Li J, Yin L, Yang J, Duan T, Wang L, Zhang X, Song X, Wang Y, Hu J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23817
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23817
SPP1 could be an immunological and prognostic biomarker: From pan-cancer comprehensive analysis to osteosarcoma validation.
Zhang Z, Liu B, Lin Z, Mei L, Chen R, Li Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23783
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jul 31;38(14):e23783
Exploring the Molecular Mechanism of Schisandrin C for the Treatment of Atherosclerosis via the PI3K/AKT/mTOR Autophagy Pathway.
Duan H, Li H, Liu T, Chen Y, Luo M, Shi Y, Zhou J, Rashed MMA, Zhai K, Li L, Wei Z
ACS omega 2024 Jul 30;9(30):32920-32930
ACS omega 2024 Jul 30;9(30):32920-32930
Hydrogen Sulfide Promotes Platelet Autophagy via PDGFR-α/PI3K/Akt Signaling in Cirrhotic Thrombocytopenia.
Yang HX, Li YJ, He YL, Jin KK, Lyu LN, Ding HG
Journal of clinical and translational hepatology 2024 Jul 28;12(7):625-633
Journal of clinical and translational hepatology 2024 Jul 28;12(7):625-633
Transcription factor 7 like 2 promotes metastasis in hepatocellular carcinoma via NEDD9-mediated activation of AKT/mTOR signaling pathway.
Tang L, Xu S, Wei R, Fan G, Zhou J, Wei X, Xu X
Molecular medicine (Cambridge, Mass.) 2024 Jul 25;30(1):108
Molecular medicine (Cambridge, Mass.) 2024 Jul 25;30(1):108
FAM134B deletion exacerbates apoptosis and epithelial-to-mesenchymal transition in rat lungs exposed to hyperoxia.
Guo H, Huang RR, Qu SS, Yao Y, Chen SH, Ding SL, Li YL
iScience 2024 Jul 19;27(7):110385
iScience 2024 Jul 19;27(7):110385
Hypoxia promotes histone H3K9 lactylation to enhance LAMC2 transcription in esophageal squamous cell carcinoma.
Zang Y, Wang A, Zhang J, Xia M, Jiang Z, Jia B, Lu C, Chen C, Wang S, Zhang Y, Wang C, Cao X, Niu Z, He C, Bai X, Tian S, Zhai G, Cao H, Chen Y, Zhang K
iScience 2024 Jul 19;27(7):110188
iScience 2024 Jul 19;27(7):110188
PRAME promotes proliferation of multiple myeloma cells through CTMP/Akt/p21/CCND3 axis by ubiquitinating CTMP and p21.
Sun K, Yang L, Wang F, Liu Y, Xu N, Shi ZY, Chen WM, Li K, Qin YZ
Heliyon 2024 Jul 15;10(13):e34094
Heliyon 2024 Jul 15;10(13):e34094
LncRNA ZFAS1 regulates ATIC transcription and promotes the proliferation and migration of hepatocellular carcinoma through the PI3K/AKT signaling pathway.
Luo B, Zhuang L, Huang J, Shi L, Zhang L, Zhu M, Lu Y, Zhu Q, Sun D, Wang H, Fang H
Journal of cancer research and clinical oncology 2024 Jul 13;150(7):351
Journal of cancer research and clinical oncology 2024 Jul 13;150(7):351
FOLR1-stabilized β-catenin promotes laryngeal carcinoma progression through EGFR/AKT/GSK-3β pathway.
Tuo H, Li X, Du H, Li M, Xu C, Yu Z, Zhao H
Molecular carcinogenesis 2024 Jan;63(1):34-44
Molecular carcinogenesis 2024 Jan;63(1):34-44
Muscle fibre transition and transcriptional changes of horse skeletal muscles during traditional Mongolian endurance training.
Bou T, Ding W, Ren X, Liu H, Gong W, Jia Z, Zhang X, Dugarjaviin M, Bai D
Equine veterinary journal 2024 Jan;56(1):178-192
Equine veterinary journal 2024 Jan;56(1):178-192
Gab2 promotes the growth of colorectal cancer by regulating the M2 polarization of tumor‑associated macrophages.
Gao X, Long R, Qin M, Zhu W, Wei L, Dong P, Chen J, Luo J, Feng J
International journal of molecular medicine 2024 Jan;53(1)
International journal of molecular medicine 2024 Jan;53(1)
MicroRNA-10a-5p-mediated downregulation of GATA6 inhibits tumor progression in ovarian cancer.
Gao F, Wu Q, Lu D
Human cell 2024 Jan;37(1):271-284
Human cell 2024 Jan;37(1):271-284
KIRREL promotes the proliferation of gastric cancer cells and angiogenesis through the PI3K/AKT/mTOR pathway.
Wang T, Chen S, Wang Z, Li S, Fei X, Wang T, Zhang M
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
Journal of cellular and molecular medicine 2024 Jan;28(1):e18020
AKR1B10 inhibits the proliferation and metastasis of hepatocellular carcinoma cells by regulating the PI3K/AKT pathway.
Tian K, Deng Y, Li Z, Zhou H, Yao H
Oncology letters 2024 Jan;27(1):18
Oncology letters 2024 Jan;27(1):18
Hematoporphyrin derivative photodynamic therapy induces apoptosis and suppresses the migration of human esophageal squamous cell carcinoma cells by regulating the PI3K/AKT/mTOR signaling pathway.
Wei X, Ni J, Yuan L, Li X
Oncology letters 2024 Jan;27(1):17
Oncology letters 2024 Jan;27(1):17
TESC acts as a prognostic factor and promotes epithelial-mesenchymal transition progression in esophageal squamous carcinoma.
Dong Y, Fan B, Li M, Zhang J, Xie S, Di S, Jia Q, Gong T
Pathology, research and practice 2024 Jan;253:154964
Pathology, research and practice 2024 Jan;253:154964
Metabolomics reveals that chronic restraint stress alleviates carbon tetrachloride-induced hepatic fibrosis through the INSR/PI3K/AKT/AMPK pathway.
Zhang S, Liu B, Huang L, Zhang R, An L, Liu Z
Journal of molecular medicine (Berlin, Germany) 2024 Jan;102(1):113-128
Journal of molecular medicine (Berlin, Germany) 2024 Jan;102(1):113-128
A novel lncRNA LOC105613571 binding with BDNF in pituitary promotes gonadotropin secretion by AKT/ERK-mTOR pathway in sheep associated with prolificacy.
Cai Y, Yang H, Wan Z, Chen PY, Wang ZB, Guo JJ, Wang D, Wang F, Zhang Y
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
BioFactors (Oxford, England) 2024 Jan-Feb;50(1):58-73
Regulation of the immune microenvironment by pioglitazone-loaded polylactic glycolic acid nanosphere composite scaffolds to promote vascularization and bone regeneration.
Fan S, Tan Y, Yuan X, Liu C, Wu X, Dai T, Ni S, Wang J, Weng Y, Zhao H
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452
Journal of tissue engineering 2024 Jan-Dec;15:20417314241231452
SPHK1/S1P/S1PR pathway promotes the progression of peritoneal fibrosis by mesothelial-mesenchymal transition.
Zhao T, Ding T, Sun Z, Shao X, Li S, Lu H, Yuan JH, Guo Z
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Jan 31;38(2):e23417
FBW7/GSK3β mediated degradation of IGF2BP2 inhibits IGF2BP2-SLC7A5 positive feedback loop and radioresistance in lung cancer.
Zhou Z, Zhang B, Deng Y, Deng S, Li J, Wei W, Wang Y, Wang J, Feng Z, Che M, Yang X, Meng J, Li Y, Hu Y, Sun Y, Wen L, Huang F, Sheng Y, Wan C, Yang K
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34
Journal of experimental & clinical cancer research : CR 2024 Jan 29;43(1):34
Network pharmacology and in vivo evidence of the pharmacological mechanism of geniposide in the treatment of atherosclerosis.
Ma G, Dong Q, Li F, Jin Z, Pi J, Wu W, Li J
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
BMC complementary medicine and therapies 2024 Jan 24;24(1):53
Investigation of Tongxie-Yaofang formula in treating ulcerative colitis based on network pharmacology via regulating MAPK/AKT signaling pathway.
Liu X, Ye M, He Y, Lai Q, Liu B, Zhang L
Aging 2024 Jan 24;16(2):1911-1924
Aging 2024 Jan 24;16(2):1911-1924
FOXP3(+) regulatory T cell perturbation mediated by the IFNγ-STAT1-IFITM3 feedback loop is essential for anti-tumor immunity.
Liu X, Zhang W, Han Y, Cheng H, Liu Q, Ke S, Zhu F, Lu Y, Dai X, Wang C, Huang G, Su B, Zou Q, Li H, Zhao W, Xiao L, Lu L, Tong X, Pan F, Li H, Li B
Nature communications 2024 Jan 2;15(1):122
Nature communications 2024 Jan 2;15(1):122
Heliox Protects SH-SY5Y Cells from Oxygen-Glucose Deprivation/Reperfusion-Induced Ferroptosis.
Yu S, Xiong W, Xu W, Chen Y
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Journal of integrative neuroscience 2024 Jan 16;23(1):14
Network pharmacology and experimental validation on yangjing zhongyu decoction against diminished ovarian reserve.
Liu J, Wei B, Ma Q, Shi D, Pan X, Liu Z, Li J, Zhao P
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Journal of ethnopharmacology 2024 Jan 10;318(Pt B):117023
Hesperetin promotes bladder cancer cells death via the PI3K/AKT pathway by network pharmacology and molecular docking.
Lv Y, Liu Z, Deng L, Xia S, Mu Q, Xiao B, Xiu Y, Liu Z
Scientific reports 2024 Jan 10;14(1):1009
Scientific reports 2024 Jan 10;14(1):1009
Manipulating HGF signaling reshapes the cirrhotic liver niche and fills a therapeutic gap in regeneration mediated by transplanted stem cells.
Zhang H, Chen Q, Hu D, Lai J, Yan M, Wu Z, Yang Z, Zheng S, Liu W, Zhang L, Bai L
Experimental cell research 2024 Jan 1;434(1):113867
Experimental cell research 2024 Jan 1;434(1):113867
Involvement of PI3K/AKT Pathway in the Rapid Antidepressant Effects of Crocetin in Mice with Depression-Like Phenotypes.
Lin S, Chen Z, Wu Z, Fei F, Xu Z, Tong Y, Sun W, Wang P
Neurochemical research 2024 Feb;49(2):477-491
Neurochemical research 2024 Feb;49(2):477-491
MiR-4524b-5p-targeting ALDH1A3 attenuates the proliferation and radioresistance of glioblastoma via PI3K/AKT/mTOR signaling.
Yu H, Li X, Li Y, Wang T, Wang M, Mao P
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
CNS neuroscience & therapeutics 2024 Feb;30(2):e14396
IGF2BP3 loss inhibits cell progression by upregulating has_circRNA_103820, and hsa_circRNA_103820-encoded peptide inhibits cell progression by inactivating the AKT pathway in lung cancer.
Zhou J, Yao L, Su Y, Tian L
Chemical biology & drug design 2024 Feb;103(2):e14473
Chemical biology & drug design 2024 Feb;103(2):e14473
Blockade of C5a receptor unleashes tumor-associated macrophage antitumor response and enhances CXCL9-dependent CD8(+) T cell activity.
Luan X, Lei T, Fang J, Liu X, Fu H, Li Y, Chu W, Jiang P, Tong C, Qi H, Fu Y
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
Molecular therapy : the journal of the American Society of Gene Therapy 2024 Feb 7;32(2):469-489
FAM76B regulates PI3K/Akt/NF-κB-mediated M1 macrophage polarization by influencing the stability of PIK3CD mRNA.
Wang J, Zhao X, Wang Q, Zheng X, Simayi D, Zhao J, Yang P, Mao Q, Xia H
Cellular and molecular life sciences : CMLS 2024 Feb 29;81(1):107
Cellular and molecular life sciences : CMLS 2024 Feb 29;81(1):107
BOP1 contributes to the activation of autophagy in polycystic ovary syndrome via nucleolar stress response.
Ji R, Zhang Z, Yang Z, Chen X, Yin T, Yang J
Cellular and molecular life sciences : CMLS 2024 Feb 27;81(1):101
Cellular and molecular life sciences : CMLS 2024 Feb 27;81(1):101
KEAP1 promotes anti-tumor immunity by inhibiting PD-L1 expression in NSCLC.
Li J, Shi D, Li S, Shi X, Liu Y, Zhang Y, Wang G, Zhang C, Xia T, Piao HL, Liu HX
Cell death & disease 2024 Feb 27;15(2):175
Cell death & disease 2024 Feb 27;15(2):175
PXMP4 promotes gastric cancer cell epithelial-mesenchymal transition via the PI3K/AKT signaling pathway.
Li W, Dong X, Wan Z, Wang W, Zhang J, Mi Y, Li R, Xu Z, Wang B, Li N, He G
Molecular biology reports 2024 Feb 24;51(1):350
Molecular biology reports 2024 Feb 24;51(1):350
DPPA2/4 Promote the Pluripotency and Proliferation of Bovine Extended Pluripotent Stem Cells by Upregulating the PI3K/AKT/GSK3β/β-Catenin Signaling Pathway.
Fang S, Wang J, Liu G, Qu B, Chunyu J, Xu W, Xiang J, Li X
Cells 2024 Feb 23;13(5)
Cells 2024 Feb 23;13(5)
Metastatic effects of perfluorooctanoic acid (PFOA) on Drosophila melanogaster with metabolic reprogramming and dysrhythmia in a multigenerational exposure scenario.
Fangninou FF, Yu Z, Li W, Xue L, Yin D
The Science of the total environment 2024 Feb 20;912:169305
The Science of the total environment 2024 Feb 20;912:169305
The pathogenicity of vancomycin-resistant Enterococcus faecalis to colon cancer cells.
Zhang L, Deng M, Liu J, Zhang J, Wang F, Yu W
BMC infectious diseases 2024 Feb 20;24(1):230
BMC infectious diseases 2024 Feb 20;24(1):230
Total flavonoids of Astragalus protects glomerular filtration barrier in diabetic kidney disease.
Liu PY, Hong KF, Liu YD, Sun ZY, Zhao TT, Li XL, Lao CC, Tan SF, Zhang HY, Zhao YH, Xie Y, Xu YH
Chinese medicine 2024 Feb 16;19(1):27
Chinese medicine 2024 Feb 16;19(1):27
Exploring the therapeutic mechanisms and prognostic targets of Biochanin A in glioblastoma via integrated computational analysis and in vitro experiments.
Ge W, Yuan G, Wang D, Dong L
Scientific reports 2024 Feb 15;14(1):3783
Scientific reports 2024 Feb 15;14(1):3783
MiR-92a-2-5p suppresses esophageal squamous cell carcinoma cell proliferation and invasion by targeting PRDX2.
Zhan X, Li J, Zeng R, Lei L, Feng A, Yang Z
Experimental cell research 2024 Feb 1;435(1):113925
Experimental cell research 2024 Feb 1;435(1):113925
Down-expression of miR-494-3p in senescent osteocyte-derived exosomes inhibits osteogenesis and accelerates age-related bone loss via PTEN/PI3K/AKT pathway.
Yao C, Sun J, Luo W, Chen H, Chen T, Chen C, Zhang B, Zhang Y
Bone & joint research 2024 Feb 1;13(2):52-65
Bone & joint research 2024 Feb 1;13(2):52-65
Amphotericin B for injection triggers degranulation of human LAD2 mast cells by MRGPRX2 and pseudo-allergic reactions in mice via MRGPRB2 activation.
He X, Yang X, Qin L, Zhang Q, Ji X, Tang W, Zhan Y, Zhang Y
Immunologic research 2024 Dec;72(6):1337-1349
Immunologic research 2024 Dec;72(6):1337-1349
Peptidylprolyl isomerase D circular RNA sensitizes breast cancer to trastuzumab through remodeling HER2 N4-acetylcytidine modification.
Wang S, Li Q, Wang Y, Li X, Feng X, Wei Y, Wang J, Zhou X
Journal of applied genetics 2024 Dec;65(4):797-807
Journal of applied genetics 2024 Dec;65(4):797-807
In silico and in vivo verification of the mechanism of formononetin in treating hepatocellular carcinoma.
Ma G, Pang X, Ran Y, Chen W, Zhou Y, Li X, Liu B, Li F, Hu S
Annals of medicine 2024 Dec;56(1):2404550
Annals of medicine 2024 Dec;56(1):2404550
MiR-19b-3p inhibits cell viability and proliferation and promotes apoptosis by targeting IGF1 in KGN cells.
Li Y, Ye Y, Zhang H, Yang Y, Zhang N, Gao H, Wu R
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2024 Dec;40(1):2425318
Gynecological endocrinology : the official journal of the International Society of Gynecological Endocrinology 2024 Dec;40(1):2425318
Novel isobavachalcone derivatives induce apoptosis and necroptosis in human non-small cell lung cancer H1975 cells.
Chen J, Zhao L, Xu MF, Huang D, Sun XL, Zhang YX, Li HM, Wu CZ
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2292006
Journal of enzyme inhibition and medicinal chemistry 2024 Dec;39(1):2292006
Polyphyllin II inhibits breast cancer cell proliferation via the PI3K/Akt signaling pathway.
Miao W, Wang Z, Gao J, Ohno Y
Molecular medicine reports 2024 Dec;30(6)
Molecular medicine reports 2024 Dec;30(6)
Christensenellaceae minuta modulates epithelial healing via PI3K-AKT pathway and macrophage differentiation in the colitis.
Yao T, Wu Y, Fu L, Lv J, Lv L, Li L
Microbiological research 2024 Dec;289:127927
Microbiological research 2024 Dec;289:127927
PX-478 induces apoptosis in acute myeloid leukemia under hypoxia by inhibiting the PI3K/AKT/mTOR pathway through downregulation of GBE1.
Liu W, Dou C, Zhang C, Chen P, Zhang S, Wang R, Han Q, Zhao H, Li D
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Biochemical pharmacology 2024 Dec;230(Pt 3):116620
Quercetin inhibits malignant progression of high metastatic advanced colon cancer in hypoxia via suppressing ROS and PI3K/AKT pathway.
Shang P, Yang J, Shao L, Sun C, Ji J, Wang X, Zheng Z, Guo X
Pharmaceutical science advances 2024 Dec;2:100057
Pharmaceutical science advances 2024 Dec;2:100057
JuA alleviates liver ischemia-reperfusion injury by activating AKT/NRF2/HO-1 pathways.
Fang H, Xu M, Zhang J, Qin H, Tang H, He Y, Guo W
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Biochimica et biophysica acta. Molecular basis of disease 2024 Dec;1870(8):167496
Rehmannioside A promotes the osteoblastic differentiation of MC3T3-E1 cells via the PI3K/AKT signaling pathway and inhibits glucocorticoid-induced bone loss in vivo.
Huang H, Ji F, Qi G, Cao Y, He X, Wang H, Jiang Z
Journal of pharmacological sciences 2024 Dec;156(4):247-257
Journal of pharmacological sciences 2024 Dec;156(4):247-257
Cepharanthine sensitizes gastric cancer cells to chemotherapy by targeting TRIB3-FOXO3-FOXM1 axis to inhibit autophagy.
Lu YY, Fang YY, Wang SS, Guo J, Song JL, Zhu L, Lin ZK, Wang R, Zhang SY, Qiu WS, Qi WW
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Dec;135:156161
Tryptophan supplements in high-carbohydrate diets by improving insulin response and glucose transport through PI3K-AKT-GLUT2 pathways in blunt snout bream (Megalobrama amblycephala).
Xiao K, Jia X, Qiang W, Chang L, Liu W, Zhang D
The Journal of nutritional biochemistry 2024 Dec;134:109715
The Journal of nutritional biochemistry 2024 Dec;134:109715
MEK inhibitor trametinib combined with PI3K/mTOR inhibitor BEZ-235 as an effective strategy against NSCLC through impairment of glucose metabolism.
Liu Y, Qing B, Ke W, Wang M
Cellular signalling 2024 Dec;124:111415
Cellular signalling 2024 Dec;124:111415
ALOX5 induces EMT and promotes cell metastasis via the LTB4/BLT2/PI3K/AKT pathway in ovarian cancer.
Ji Z, Li X, Gao W, Xia Q, Li J
Cellular signalling 2024 Dec;124:111404
Cellular signalling 2024 Dec;124:111404
miR-134-3p Regulates Cell Proliferation and Apoptosis by Targeting INHBA via Inhibiting the TGF-β/PI3K/AKT Pathway in Sheep Granulosa Cells.
Huang X, Bao Y, Yang F, Li X, Wang F, Zhang C
Biology 2024 Dec 30;14(1)
Biology 2024 Dec 30;14(1)
Single-cell view and a novel protective macrophage subset in perivascular adipose tissue in T2DM.
Li J, Tian Z, Zhang T, Jin J, Zhang X, Xie P, Lin H, Gu J, Wu Y, Wang X, Zhang S, Yan X, Guo D, Wang Z, Zhang Q
Cellular & molecular biology letters 2024 Dec 3;29(1):148
Cellular & molecular biology letters 2024 Dec 3;29(1):148
The dual role of calnexin on malignant progression and tumor microenvironment in glioma.
Wang W, Shi Y, Yan B, Cai Y, Zheng H, Zhang Y, Wang L, Wang H
Scientific reports 2024 Dec 28;14(1):30796
Scientific reports 2024 Dec 28;14(1):30796
SIRT7 inhibits the aging and inflammatory damage of hPDLFs by suppressing the AKT/mTOR.
Sun J, Li Y, Meng M, Zeng X, Wang Q, Li W, Luo Y, Chen H, Dong Q
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
International immunopharmacology 2024 Dec 25;143(Pt 1):113300
OSGEP regulates islet β-cell function by modulating proinsulin translation and maintaining ER stress homeostasis in mice.
Liu Y, Yang X, Zhou J, Yang H, Yang R, Zhu P, Zhou R, Wu T, Gao Y, Ye Z, Li X, Liu R, Zhang W, Zhou H, Li Q
Nature communications 2024 Dec 2;15(1):10479
Nature communications 2024 Dec 2;15(1):10479
Osteoblast-derived exosomal miR-140-3p targets ACER2 and increases the progression of prostate cancer via the AKT/mTOR pathway-mediated inhibition of autophagy.
Liu Y, Chen S, Guo K, Ma S, Wang X, Liu Q, Yan R, Huang Y, Li T, He S, Hui J
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70206
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2024 Dec 15;38(23):e70206
The vitamin D receptor is essential for the replication of pseudorabies virus.
Zeng L, Wang S-Y, Du M-H, Chu B-B, Ming S-L
mBio 2024 Dec 11;15(12):e0213724
mBio 2024 Dec 11;15(12):e0213724
Potential Effects of Indomethacin on Alleviating Osteoarthritis Progression in Vitro.
Zhao X, Wang T, Li N, Meng Z, Wang W, Wang B, Song D
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
Journal of musculoskeletal & neuronal interactions 2024 Dec 1;24(4):409-419
High Dose of Estrogen Protects the Lungs from Ischemia-Reperfusion Injury by Downregulating the Angiotensin II Signaling Pathway.
Dai P, He J, Wei Y, Xu M, Zhao J, Zhou X, Tang H
Inflammation 2024 Aug;47(4):1248-1261
Inflammation 2024 Aug;47(4):1248-1261
Effect of elastin on abnormal proliferation of pulmonary artery smooth muscle cells at an early stage of hypoxic exposure.
Dong H, Li P, Wang X, Zhang Y, Han F, Gao S, Hu W, Hao X
Journal of receptor and signal transduction research 2024 Aug;44(4):129-139
Journal of receptor and signal transduction research 2024 Aug;44(4):129-139
IL-33-dependent NF-κB activation inhibits apoptosis and drives chemoresistance in acute myeloid leukemia.
Yan M, Chen X, Ye Q, Li H, Zhang L, Wang Y
Cytokine 2024 Aug;180:156672
Cytokine 2024 Aug;180:156672
Digirseophene A promotes recovery in injured developing cerebellum via AMPK/AKT/GSK3β pathway-mediated neural stem cell proliferation.
Tang X, Huang Y, Fu W, Wang P, Feng L, Yang J, Zhu H, Huang X, Ming Q, Li P
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117046
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117046
Tanshinone I improves TNBC chemosensitivity by suppressing late-phase autophagy through AKT/p38 MAPK signaling pathway.
Tang X, Gong J, Ren L, Wang Z, Yang B, Wang W, Wang N
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117037
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2024 Aug;177:117037
Lactate dehydrogenase A (LDHA)-mediated lactate generation promotes pulmonary vascular remodeling in pulmonary hypertension.
Wu D, Wang S, Wang F, Zhang Q, Zhang Z, Li X
Journal of translational medicine 2024 Aug 5;22(1):738
Journal of translational medicine 2024 Aug 5;22(1):738
GGT5 as a promising prognostic biomarker and its effects on tumor cell progression in gastric cancer.
Chen W, Yang F, Shen H, Xu J, Chen J, Zhang Z, Xu J, Xu B
Translational cancer research 2024 Aug 31;13(8):4459-4473
Translational cancer research 2024 Aug 31;13(8):4459-4473
Ac-HSP20 regulates autophagy and promotes the encystation of Acanthamoeba castellanii by inhibiting the PI3K/AKT/mTOR signaling pathway.
Guo S, Liu D, Wan X, Guo D, Zheng M, Zheng W, Feng X
Parasites & vectors 2024 Aug 19;17(1):347
Parasites & vectors 2024 Aug 19;17(1):347
MZT2A serves as a prognostic biomarker and promotes the progression of kidney renal clear cell carcinoma.
Cao L, Jing X, Liu L, Wang H, Zhu J, Zhou J, Peng H, Zhang J, Li F, Wang X, Zhao L
Heliyon 2024 Aug 15;10(15):e35695
Heliyon 2024 Aug 15;10(15):e35695
Identification of epithelial-related artificial neural network prognostic models for the prediction of bladder cancer prognosis through comprehensive analysis of single-cell and bulk RNA sequencing.
Zhao F, Zhang K, Ma L, Huang Y
Heliyon 2024 Aug 15;10(15):e34632
Heliyon 2024 Aug 15;10(15):e34632
Targeted degradation of NDUFS1 by agrimol B promotes mitochondrial ROS accumulation and cytotoxic autophagy arrest in hepatocellular carcinoma.
Dong L, Luo L, Wang Z, Lian S, Wang M, Wu X, Fan J, Zeng Y, Li S, Lv S, Yang Y, Chen R, Shen E, Yang W, Li C, Wang K
Free radical biology & medicine 2024 Aug 1;220:111-124
Free radical biology & medicine 2024 Aug 1;220:111-124
Cytoplasmic localization of SETDB1‑induced Warburg effect via c‑MYC‑LDHA axis enhances migration and invasion in breast carcinoma.
Yang W, Wei Y, Wang T, Xu Y, Jin X, Qian H, Yang S, He S
International journal of molecular medicine 2024 Apr;53(4)
International journal of molecular medicine 2024 Apr;53(4)
Ganoderic acids alleviate atherosclerosis by inhibiting macrophage M1 polarization via TLR4/MyD88/NF-κB signaling pathway.
Quan YZ, Ma A, Ren CQ, An YP, Qiao PS, Gao C, Zhang YK, Li XW, Lin SM, Li NN, Chen DL, Pan Y, Zhou H, Lin DM, Lin SQ, Li M, Yang BX
Atherosclerosis 2024 Apr;391:117478
Atherosclerosis 2024 Apr;391:117478
A Pt(II) complex bearing N-heterocycle ring induced ferroptotic cell death in ovarian cancer.
Shen X, Peng Y, Zhou H, Ye X, Han Z, Shi X
Journal of inorganic biochemistry 2024 Apr;253:112502
Journal of inorganic biochemistry 2024 Apr;253:112502
H3K18 lactylation-mediated VCAM1 expression promotes gastric cancer progression and metastasis via AKT-mTOR-CXCL1 axis.
Zhao Y, Jiang J, Zhou P, Deng K, Liu Z, Yang M, Yang X, Li J, Li R, Xia J
Biochemical pharmacology 2024 Apr;222:116120
Biochemical pharmacology 2024 Apr;222:116120
The regulatory role of the apelin/APJ axis in scarring: Identification of upstream and downstream mechanisms.
Shi N, Wang Y, Xia Z, Zhang J, Jia S, Jiao Y, Wang C, Wang X, Zhao J, Zhang J, Jiang D
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167125
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167125
Resistance exercise preconditioning prevents disuse muscle atrophy by inhibiting apoptosis and protein degradation via SESN2 in C57BL/6J mice.
Huang Y, Jiang C, Li X, Liu S, Niu Y, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Biochimica et biophysica acta. Molecular basis of disease 2024 Apr;1870(4):167111
Thromboxane A2/thromboxane A2 receptor axis facilitates hepatic insulin resistance and steatosis through endoplasmic reticulum stress in non-alcoholic fatty liver disease.
Dai Y, Xu R, Chen J, Fang J, Zhang H, Li H, Chen W
British journal of pharmacology 2024 Apr;181(7):967-986
British journal of pharmacology 2024 Apr;181(7):967-986
Catalpol alleviates hypoxia ischemia-induced brain damage by inhibiting ferroptosis through the PI3K/NRF2/system Xc-/GPX4 axis in neonatal rats.
Lin J, Deng L, Qi A, Jiang H, Xu D, Zheng Y, Zhang Z, Guo X, Hu B, Li P
European journal of pharmacology 2024 Apr 5;968:176406
European journal of pharmacology 2024 Apr 5;968:176406
Circulating tumor cells shielded with extracellular vesicle-derived CD45 evade T cell attack to enable metastasis.
Yang C, Wang X, To KKW, Cui C, Luo M, Wu S, Huang L, Fu K, Pan C, Liu Z, Fan T, Yang C, Wang F, Fu L
Signal transduction and targeted therapy 2024 Apr 5;9(1):84
Signal transduction and targeted therapy 2024 Apr 5;9(1):84
The mechanisms of MicroRNA 21 in premature ovarian insufficiency mice with mesenchymal stem cells transplantation : The involved molecular and immunological mechanisms.
Yin N, Luo C, Wei L, Yang G, Bo L, Mao C
Journal of ovarian research 2024 Apr 4;17(1):75
Journal of ovarian research 2024 Apr 4;17(1):75
Exploring the neuroprotection of the combination of astragaloside A, chlorogenic acid and scutellarin in treating chronic cerebral ischemia via network analysis and experimental validation.
Cheng F, Zhang J, Yang P, Chen Z, Fu Y, Mi J, Xie X, Liu S, Sheng Y
Heliyon 2024 Apr 30;10(8):e29162
Heliyon 2024 Apr 30;10(8):e29162
The Lipophilic Extract from Ginkgo biloba L. Leaves Promotes Glucose Uptake and Alleviates Palmitate-Induced Insulin Resistance in C2C12 Myotubes.
Li T, Lv Q, Liu C, Li C, Xie X, Zhang W
Molecules (Basel, Switzerland) 2024 Apr 3;29(7)
Molecules (Basel, Switzerland) 2024 Apr 3;29(7)
MATN2 overexpression suppresses tumor growth in ovarian cancer via PTEN/PI3K/AKT pathway.
Liu J, Zhang J, Zhang Y, Yang B, Liu H, Chen Y
Functional & integrative genomics 2024 Apr 3;24(2):71
Functional & integrative genomics 2024 Apr 3;24(2):71
Mas receptor activation facilitates innate hematoma resolution and neurological recovery after hemorrhagic stroke in mice.
Deng X, Ren J, Chen K, Zhang J, Zhang Q, Zeng J, Li T, Tang Q, Lin J, Zhu J
Journal of neuroinflammation 2024 Apr 24;21(1):106
Journal of neuroinflammation 2024 Apr 24;21(1):106
Exploring the Potential Mechanisms of Guanxinshutong Capsules in Treating Pathological Cardiac Hypertrophy based on Network Pharmacology, Computer-Aided Drug Design, and Animal Experiments.
Liu Y, Li Q, Shao C, She Y, Zhou H, Guo Y, An H, Wang T, Yang J, Wan H
ACS omega 2024 Apr 23;9(16):18083-18098
ACS omega 2024 Apr 23;9(16):18083-18098
METTL14 promotes neuroblastoma formation by inhibiting YWHAH via an m6A-YTHDF1-dependent mechanism.
Wang J, Yin H, Li G, Wu D, Xu Y, Chen Y, Wang X, Xing Y, Zhang T, Fei D, Yang P, Fang F, Tao Y, Li X, Yu J, Yang Y, Li Z, Shi L, Zhang Z, Pan J
Cell death discovery 2024 Apr 22;10(1):186
Cell death discovery 2024 Apr 22;10(1):186
SGMS1 facilitates osteogenic differentiation of MSCs and strengthens osteogenesis-angiogenesis coupling by modulating Cer/PP2A/Akt pathway.
Yang K, Luan YY, Wang S, Yan YS, Wang YP, Wu J, Sun YQ, Zhang J, Chen WQ, Xiang YL, Li ZL, Zhang DL, Yin CH
iScience 2024 Apr 19;27(4):109358
iScience 2024 Apr 19;27(4):109358
Semisynthesis and in Vitro Anti-cancer Effect of New Magnolol Derivatives on the Cell Proliferation, Apoptosis, Migration, and Invasion of Human Hepatocellular Carcinoma SMMC-7721 Cells.
He NN, Wang JA, Huang D, Sun XL, Ding F, Zhao L, Zhang YX, Li HM, Wu CZ
Chemical & pharmaceutical bulletin 2023;71(11):798-803
Chemical & pharmaceutical bulletin 2023;71(11):798-803
Herpetrione, a New Type of PPARα Ligand as a Therapeutic Strategy Against Nonalcoholic Steatohepatitis.
Linghu L, Zong W, Liao Y, Chen Q, Meng F, Wang G, Liao Z, Lan X, Chen M
Research (Washington, D.C.) 2023;6:0276
Research (Washington, D.C.) 2023;6:0276
Inhibition of Ehrlich ascites carcinoma growth by melatonin: Studies with micro-CT.
Yilmaz S, Doğanyiğit Z, Ocak M, Söylemez ESA, Oflamaz AO, Uçar S, Ateş Ş, Farooqi AA
Oncology research 2023;32(1):175-185
Oncology research 2023;32(1):175-185
Mechanism of Xiezhuo Huayu Yiqi Tongluo Formula in the Treatment of Uric Acid Nephropathy Based on Network Pharmacology, Molecular Docking, and In Vivo Experiments.
Fan L, Guo Y, Wu Q, Hu T, Chen X, Guo J, Liu Y, Lu Y, Lin M
Evidence-based complementary and alternative medicine : eCAM 2023;2023:6931644
Evidence-based complementary and alternative medicine : eCAM 2023;2023:6931644
Upregulation of LRRC8A by m(5)C modification-mediated mRNA stability suppresses apoptosis and facilitates tumorigenesis in cervical cancer.
Chen Y, Zuo X, Wei Q, Xu J, Liu X, Liu S, Wang H, Luo Q, Wang Y, Yang Y, Zhao H, Xu J, Liu T, Yi P
International journal of biological sciences 2023;19(2):691-704
International journal of biological sciences 2023;19(2):691-704
Chemokine receptor CXCR2 in primary sensory neurons of trigeminal ganglion mediates orofacial itch.
Li DJ, Zhong ZJ, Wang XL, Wei N, Zhao SJ, Shan TT, Liu YP, Yu YQ
Frontiers in molecular neuroscience 2023;16:1279237
Frontiers in molecular neuroscience 2023;16:1279237
SHCBP1 Promotes the Proliferation of Breast Cancer Cells by Inhibiting CXCL2.
Yu X, Feng G, Nian R, Han S, Ke M, Wang L, Li W, Tian S, Lu H
Journal of Cancer 2023;14(18):3444-3456
Journal of Cancer 2023;14(18):3444-3456
HECW2 promotes the progression and chemoresistance of colorectal cancer via AKT/mTOR signaling activation by mediating the ubiquitin-proteasome degradation of lamin B1.
Li F, Wang L, Wang Y, Shen H, Kou Q, Shen C, Xu X, Zhang Y, Zhang J
Journal of Cancer 2023;14(15):2820-2832
Journal of Cancer 2023;14(15):2820-2832
Artesunate, as an Hsp90 inhibitor, inhibits the proliferation of Burkitt's lymphoma cells by inhibiting AKT and ERK.
Yuan-Ce L, Qi Z, Hong-Yang Z, Yan-Wen W, Yu-Mei S, Bi-Juan Y, Jun-Lin Y
Frontiers in pharmacology 2023;14:1218467
Frontiers in pharmacology 2023;14:1218467
Tirzepatide ameliorates spatial learning and memory impairment through modulation of aberrant insulin resistance and inflammation response in diabetic rats.
Guo X, Lei M, Zhao J, Wu M, Ren Z, Yang X, Ouyang C, Liu X, Liu C, Chen Q
Frontiers in pharmacology 2023;14:1146960
Frontiers in pharmacology 2023;14:1146960
Mechanism of action of icaritin on uterine corpus endometrial carcinoma based on network pharmacology and experimental evaluation.
Jin YB, Liang XC, Cai JH, Wang K, Wang CY, Wang WH, Chen XL, Bao S
Frontiers in oncology 2023;13:1205604
Frontiers in oncology 2023;13:1205604
MiR-93-5p inhibits retinal neurons apoptosis by regulating PDCD4 in acute ocular hypertension model.
Tan C, Shi W, Zhang Y, Liu C, Hu T, Chen D, Huang J
Life science alliance 2023 Sep;6(9)
Life science alliance 2023 Sep;6(9)
Cuproptosis enhances docetaxel chemosensitivity by inhibiting autophagy via the DLAT/mTOR pathway in prostate cancer.
Wen H, Qu C, Wang Z, Gao H, Liu W, Wang H, Sun H, Gu J, Yang Z, Wang X
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Sep;37(9):e23145
ANRIL promotes the regulation of colorectal cancer on lymphatic endothelial cells via VEGF-C and is the key target for Pien Tze Huang to inhibit cancer metastasis.
Huang B, Lu Y, Ni Z, Liu J, He Y, An H, Ye F, Shen J, Lin M, Chen Y, Lin J
Cancer gene therapy 2023 Sep;30(9):1260-1273
Cancer gene therapy 2023 Sep;30(9):1260-1273
Loss of NSUN6 inhibits osteosarcoma progression by downregulating EEF1A2 expression and activation of Akt/mTOR signaling pathway via m(5)C methylation.
Hu S, Yang M, Xiao K, Yang Z, Cai L, Xie Y, Wang L, Wei R
Experimental and therapeutic medicine 2023 Sep;26(3):457
Experimental and therapeutic medicine 2023 Sep;26(3):457
miR-181b promotes angiogenesis and neurological function recovery after ischemic stroke.
Xue LX, Shu LY, Wang HM, Lu KL, Huang LG, Xiang JY, Geng Z, Zhao YW, Chen H
Neural regeneration research 2023 Sep;18(9):1983-1989
Neural regeneration research 2023 Sep;18(9):1983-1989
Yueju volatile oil plays an integral role in the antidepressant effect by up-regulating ERK/AKT-mediated GLT-1 expression to clear glutamate.
Zhang B, Su D, Song Y, Li H, Chen C, Liao L, Zhang H, Luo J, Yang M, Zhu G, Ai Z
Fitoterapia 2023 Sep;169:105583
Fitoterapia 2023 Sep;169:105583
Ze-Qi decoction inhibits non-small cell lung cancer growth and metastasis by modulating the PI3K/Akt/p53 signaling pathway.
Zhang J, Zhuang Z, Guo M, Wu K, Yang Q, Min X, Cui W, Xu F
Journal of traditional and complementary medicine 2023 Sep;13(5):417-429
Journal of traditional and complementary medicine 2023 Sep;13(5):417-429
Asarinin attenuates bleomycin-induced pulmonary fibrosis by activating PPARγ.
Zeng Q, Zhou TT, Huang WJ, Huang XT, Huang L, Zhang XH, Sang XX, Luo YY, Tian YM, Wu B, Liu L, Luo ZQ, He B, Liu W, Tang SY
Scientific reports 2023 Sep 7;13(1):14706
Scientific reports 2023 Sep 7;13(1):14706
Degenerated nucleus pulposus cells derived exosome carrying miR-27a-3p aggravates intervertebral disc degeneration by inducing M1 polarization of macrophages.
Zhao X, Sun Z, Xu B, Duan W, Chang L, Lai K, Ye Z
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Journal of nanobiotechnology 2023 Sep 4;21(1):317
Human umbilical cord-derived mesenchymal stem cells (hUC-MSCs) alleviate excessive autophagy of ovarian granular cells through VEGFA/PI3K/AKT/mTOR pathway in premature ovarian failure rat model.
Dai W, Yang H, Xu B, He T, Liu L, Ma X, Ma J, Yang G, Si R, Pei X, Du X, Fu X
Journal of ovarian research 2023 Sep 30;16(1):198
Journal of ovarian research 2023 Sep 30;16(1):198
SQLE Knockdown inhibits bladder cancer progression by regulating the PTEN/AKT/GSK3β signaling pathway through P53.
Zou F, Chen W, Song T, Xing J, Zhang Y, Chen K, Hu W, Li L, Ning J, Li C, Yu W, Cheng F
Cancer cell international 2023 Sep 28;23(1):221
Cancer cell international 2023 Sep 28;23(1):221
DKK1 Promotes Epithelial-Mesenchymal Transition and Cisplatin Resistance in Gastric Cancer via Activation of the PI3K/AKT Pathway.
Li J, Zhang Y, Ye F, Qian P, Qin Z, Li D, Ye L, Feng L
Cancers 2023 Sep 27;15(19)
Cancers 2023 Sep 27;15(19)
Carbon Ions Suppress Angiogenesis and Lung Metastases in Melanoma by Targeting CXCL10.
Li C, Zhang Q, Luo H, Liu R, Feng S, Geng Y, Wang L, Yang Z, Zhang Y, Wang X
Radiation research 2023 Sep 1;200(3):307-319
Radiation research 2023 Sep 1;200(3):307-319
Targeting HSP90 with picropodophyllin suppresses gastric cancer tumorigenesis by disrupting the association of HSP90 and AKT.
Li X, Wang G, Zhou X, Zhao H, Chen X, Cui Q, Li M, Gao X, Wei X, Ye L, Li D, Hong P
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Phytotherapy research : PTR 2023 Oct;37(10):4740-4754
Irreversible repolarization of tumour-associated macrophages by low-Pi stress inhibits the progression of hepatocellular carcinoma.
Lv YF, Liao ZQ, Bi QC, Xie CS, Wei XY, Yun Y, He YQ, Tang Q
Journal of cellular and molecular medicine 2023 Oct;27(19):2906-2921
Journal of cellular and molecular medicine 2023 Oct;27(19):2906-2921
17-DMAG ameliorates neuroinflammation and BBB disruption via SOX5 mediated PI3K/Akt pathway after intracerebral hemorrhage in rats.
Hu D, Mo X, Luo J, Wang F, Huang C, Xie H, Jin L
International immunopharmacology 2023 Oct;123:110698
International immunopharmacology 2023 Oct;123:110698
Anti-rheumatoid arthritis effects of total saponins from Rhizoma Panacis Majoris on adjuvant-induced arthritis in rats and rheumatoid arthritis fibroblast-like synoviocytes.
Ren M, Ma K, Pang X, Liu Y, Song Z, Zhou R, Tang Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Oct;119:155021
Liquiritigenin regulates insulin sensitivity and ameliorates inflammatory responses in the nonalcoholic fatty liver by activation PI3K/AKT pathway.
Bao L, Hao P, Jiang M, Chu W
Chemical biology & drug design 2023 Oct;102(4):793-804
Chemical biology & drug design 2023 Oct;102(4):793-804
Acteoside protects podocyte against apoptosis through regulating AKT/GSK-3β signaling pathway in db/db mice.
Li X, Liu Z, He Z, Wang X, Li R, Wang J, Ma G, Zhang P, Ma C
BMC endocrine disorders 2023 Oct 23;23(1):230
BMC endocrine disorders 2023 Oct 23;23(1):230
Identification of Potential Mechanisms of Rk1 Combination with Rg5 in the Treatment of Type II Diabetes Mellitus by Integrating Network Pharmacology and Experimental Validation.
Liu Y, Zhang J, An C, Liu C, Zhang Q, Ding H, Ma S, Xue W
International journal of molecular sciences 2023 Oct 2;24(19)
International journal of molecular sciences 2023 Oct 2;24(19)
Jin-Gui-Shen-Qi Wan ameliorates diabetic retinopathy by inhibiting apoptosis of retinal ganglion cells through the Akt/HIF-1α pathway.
Liang D, Qi Y, Liu L, Chen Z, Tang S, Tang J, Chen N
Chinese medicine 2023 Oct 12;18(1):130
Chinese medicine 2023 Oct 12;18(1):130
Integrative analysis reveals that SLC38A1 promotes hepatocellular carcinoma development via PI3K/AKT/mTOR signaling via glutamine mediated energy metabolism.
Feng HG, Wu CX, Zhong GC, Gong JP, Miao CM, Xiong B
Journal of cancer research and clinical oncology 2023 Nov;149(17):15879-15898
Journal of cancer research and clinical oncology 2023 Nov;149(17):15879-15898
Meroterpenoids from Daphne genkwa shows promising in vitro antitumor activity via inhibiting PI3K/Akt/mTOR signaling pathway in A549 cells.
Ma RF, Liu H, Zhao XC, Shan P, Sun P, Xue JJ, Wei G, Zhang H
Bioorganic chemistry 2023 Nov;140:106803
Bioorganic chemistry 2023 Nov;140:106803
MiR-26a-5p exerts its influence by targeting EP300, a molecule known for its role in activating the PI3K/AKT/mTOR signaling pathway in CD8+tumor-infiltrating lymphocytes of colorectal cancer.
Wang C, Lin H, Zhao W, Liang Y, Chen Y, Wang C
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 30;69(12):232-241
Cellular and molecular biology (Noisy-le-Grand, France) 2023 Nov 30;69(12):232-241
Synergistic anti-tumour activity of ginsenoside Rg3 and doxorubicin on proliferation, metastasis and angiogenesis in osteosarcoma by modulating mTOR/HIF-1α/VEGF and EMT signalling pathways.
Zeng X, Liu S, Yang H, Jia M, Liu W, Zhu W
The Journal of pharmacy and pharmacology 2023 Nov 23;75(11):1405-1417
The Journal of pharmacy and pharmacology 2023 Nov 23;75(11):1405-1417
WIPF1 promotes gastric cancer progression by regulating PI3K/Akt signaling in a myocardin-dependent manner.
Su F, Xiao R, Chen R, Yang T, Wang D, Xu X, Hou X, Guan Q, Feng M
iScience 2023 Nov 17;26(11):108273
iScience 2023 Nov 17;26(11):108273
The total alkaloids of Sophora alopecuroides L. improve depression-like behavior in mice via BDNF-mediated AKT/mTOR signaling pathway.
Li J, Zhang M, Pei Y, Yang Q, Zheng L, Wang G, Sun Y, Yang W, Liu L
Journal of ethnopharmacology 2023 Nov 15;316:116723
Journal of ethnopharmacology 2023 Nov 15;316:116723
Study on the Alleviating Effect and Potential Mechanism of Ethanolic Extract of Limonium aureum (L.) Hill. on Lipopolysaccharide-Induced Inflammatory Responses in Macrophages.
Yang Z, Man J, Liu Y, Zhang H, Wu D, Shao D, Hao B, Wang S
International journal of molecular sciences 2023 Nov 13;24(22)
International journal of molecular sciences 2023 Nov 13;24(22)
Sevoflurane Preconditioning Alleviates Posttraumatic Stress Disorder-Induced Apoptosis in the Hippocampus via the EZH2-Regulated Akt/mTOR Axis and Improves Synaptic Plasticity.
Gu T, Xu C, Meng X, Gao D, Jiang G, Yin A, Liu Q, Zhang L
Journal of molecular neuroscience : MN 2023 May;73(4-5):225-236
Journal of molecular neuroscience : MN 2023 May;73(4-5):225-236
Silk Fibroin and Sericin Differentially Potentiate the Paracrine and Regenerative Functions of Stem Cells Through Multiomics Analysis.
Zhang Y, Sheng R, Chen J, Wang H, Zhu Y, Cao Z, Zhao X, Wang Z, Liu C, Chen Z, Zhang P, Kuang B, Zheng H, Shen C, Yao Q, Zhang W
Advanced materials (Deerfield Beach, Fla.) 2023 May;35(20):e2210517
Advanced materials (Deerfield Beach, Fla.) 2023 May;35(20):e2210517
Targeting complement C5a to improve radiotherapy sensitivity in non-small cell lung cancer.
Yuan M, Wang C, Wu Y, Qiao L, Deng G, Liang N, Chen F, Liu L, Chen Y, Yang Y, Wang H, Liu T, Yang X, Zhang Y, Lv Y, Suwinski R, Hu P, Zhang Y, Zhang J
Translational lung cancer research 2023 May 31;12(5):1093-1107
Translational lung cancer research 2023 May 31;12(5):1093-1107
LMNB1 deletion in ovarian cancer inhibits the proliferation and metastasis of tumor cells through PI3K/Akt pathway.
Dong J, Ru Y, Zhai L, Gao Y, Guo X, Chen B, Lv X
Experimental cell research 2023 May 15;426(2):113573
Experimental cell research 2023 May 15;426(2):113573
Persistent Degradation of HER2 Protein by Hybrid nanoPROTAC for Programmed Cell Death.
Wang Z, Tan M, Su W, Huang W, Zhang J, Jia F, Cao G, Liu X, Song H, Ran H, Nie G, Wang H
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
Journal of medicinal chemistry 2023 May 11;66(9):6263-6273
Liver X receptor agonists exert antitumor effects against hepatocellular carcinoma via inducing REPS2 expression.
He XY, Zhu MM, Zheng J, Wang CY, Zhao XK, Zhang BT, Zhou DC, Zhang S, Yang XX, Duan YJ, Han JH, Chen YL
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
Acta pharmacologica Sinica 2023 Mar;44(3):635-646
Physalin A alleviates intervertebral disc degeneration via anti-inflammatory and anti-fibrotic effects.
Lu R, Xu H, Deng X, Wang Y, He Z, Xu S, Liang S, Huang X, You H, Guo F, Cheng P, Chen AM
Journal of orthopaedic translation 2023 Mar;39:74-87
Journal of orthopaedic translation 2023 Mar;39:74-87
microRNA-17 is a tumor suppressor in oral squamous cell carcinoma and is repressed by LSD1.
Wangzhou K, Fu W, Li M, Lu Z, Lai Z, Liu C, Tan Y, Hao C
Oral diseases 2023 Mar;29(2):491-504
Oral diseases 2023 Mar;29(2):491-504
Aspirin increases the efficacy of gemcitabine in pancreatic cancer by modulating the PI3K/AKT/mTOR signaling pathway and reversing epithelial‑mesenchymal transition.
Zhou H, Yun X, Shu Y, Xu K
Oncology letters 2023 Mar;25(3):101
Oncology letters 2023 Mar;25(3):101
GIPC2 is a tumor suppressor gene for acute myeloid leukemia and induces apoptosis of leukemia cells by regulating the PI3K/AKT pathway.
Zhao J, Liu J, Liu S, Tian S, Yuan H, Li S
Epigenomics 2023 Mar;15(6):369-383
Epigenomics 2023 Mar;15(6):369-383
A peptide encoded by lncRNA MIR7-3 host gene (MIR7-3HG) alleviates dexamethasone-induced dysfunction in pancreatic β-cells through the PI3K/AKT signaling pathway.
Mao X, Zhou J, Kong L, Zhu L, Yang D, Zhang Z
Biochemical and biophysical research communications 2023 Mar 5;647:62-71
Biochemical and biophysical research communications 2023 Mar 5;647:62-71
Activation of HCA2 regulates microglial responses to alleviate neurodegeneration in LPS-induced in vivo and in vitro models.
He D, Fu S, Ye B, Wang H, He Y, Li Z, Li J, Gao X, Liu D
Journal of neuroinflammation 2023 Mar 29;20(1):86
Journal of neuroinflammation 2023 Mar 29;20(1):86
BI-D1870 Induces Mitotic Dysfunction and Apoptosis in Neuroblastoma by Regulating the PI3K-Akt-mTORC1 Signal Axis.
Jin L, Mi T, Wu X, Wang Z, Zhang Z, Liu J, Wang Z, Wang J, Li M, Ren C, Guo P, He D
Cancers 2023 Mar 28;15(7)
Cancers 2023 Mar 28;15(7)
Fatostatin induces ferroptosis through inhibition of the AKT/mTORC1/GPX4 signaling pathway in glioblastoma.
Cai J, Ye Z, Hu Y, Ye L, Gao L, Wang Y, Sun Q, Tong S, Zhang S, Wu L, Yang J, Chen Q
Cell death & disease 2023 Mar 25;14(3):211
Cell death & disease 2023 Mar 25;14(3):211
Identification of a novel small-molecule inhibitor of miR-29b attenuates muscle atrophy.
Liu Q, Yuan W, Yan Y, Jin B, You M, Liu T, Gao M, Li J, Gokulnath P, Vulugundam G, Li G, Xu B, Xiao J
Molecular therapy. Nucleic acids 2023 Mar 14;31:527-540
Molecular therapy. Nucleic acids 2023 Mar 14;31:527-540
Berbamine dihydrochloride suppresses the progression of colorectal cancer via RTKs/Akt axis.
Liu L, Liang D, Zheng Q, Zhao M, Lv R, Tang J, Chen N
Journal of ethnopharmacology 2023 Mar 1;303:116025
Journal of ethnopharmacology 2023 Mar 1;303:116025
ARID3A plays a key regulatory role in palmitic acid-stimulated milk fat synthesis in mouse mammary epithelial cells.
Guo X, Qi H, Lin G, Yu J, Zhang M, Gao X
Cell biology international 2023 Jun;47(6):1106-1117
Cell biology international 2023 Jun;47(6):1106-1117
Protective Effect and Mechanism of Kuntai Capsule on Angiotensin II -Induced Hypertension in Ovariectomized Rats.
Ge XF, Li SS, Liu YH, Lu MQ, Su HN, Yang X, Sun XW
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Chinese journal of integrative medicine 2023 Jun;29(6):526-533
Silencing of FAM111B inhibits tumor growth and promotes apoptosis by decreasing AKT activity in ovarian cancer.
Wang W, Gu Y, Ni H, Quan Q, Guo L
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Experimental biology and medicine (Maywood, N.J.) 2023 Jun;248(12):1043-1055
Differences in p38-STAT3-S100A11 signaling after the administration of aristolochic acid I and IVa may account for the disparity in their nephrotoxicity.
Xian Z, Tian J, Zhao Y, Yi Y, Li C, Han J, Zhang Y, Wang Y, Wang L, Liu S, Pan C, Liu C, Wang D, Meng J, Tang X, Wang F, Liang A
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154815
A systematic pharmacology-based in vivo study to reveal the effective mechanism of Yupingfeng in asthma treatment.
Liu X, Yu Y, Wu Y, Luo A, Yang M, Li T, Li T, Mao B, Chen X, Fu J, Jiang H, Liu W
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154783
Phytomedicine : international journal of phytotherapy and phytopharmacology 2023 Jun;114:154783
Visceral adipose tissue-directed human kallistatin gene therapy improves adipose tissue remodeling and metabolic health in obese mice.
Wu Y, Jiang Y, Guo JQ, Yang ZW, Carvalho A, Qian LL, Ji JJ, Ji ZJ, Ma GS, Yao YY
Cellular signalling 2023 Jun;106:110637
Cellular signalling 2023 Jun;106:110637
Polystyrene microplastics mediate inflammatory responses in the chicken thymus by Nrf2/NF-κB pathway and trigger autophagy and apoptosis.
Li J, Yin K, Hou L, Zhang Y, Lu H, Ma C, Xing M
Environmental toxicology and pharmacology 2023 Jun;100:104136
Environmental toxicology and pharmacology 2023 Jun;100:104136
Tumor-Associated Fibroblast-Derived Exosomal circDennd1b Promotes Pituitary Adenoma Progression by Modulating the miR-145-5p/ONECUT2 Axis and Activating the MAPK Pathway.
Jiang Q, Lei Z, Wang Z, Wang Q, Zhang Z, Liu X, Xing B, Li S, Guo X, Liu Y, Li X, Qi Y, Shu K, Zhang H, Huang Y, Lei T
Cancers 2023 Jun 27;15(13)
Cancers 2023 Jun 27;15(13)
EZH2 Gene Knockdown Inhibits Sheep Pituitary Cell Proliferation via Downregulating the AKT/ERK Signaling Pathway.
Cai Y, Chen P, Xu H, Li S, Zhao B, Fan Y, Wang F, Zhang Y
International journal of molecular sciences 2023 Jun 26;24(13)
International journal of molecular sciences 2023 Jun 26;24(13)
Ginsenoside Rk3 Regulates Nonalcoholic Steatohepatitis by Modulation of Intestinal Flora and the PI3K/AKT Signaling Pathway in C57BL/6 Mice.
Guo M, Zhu C, Fu R, Ma X, Duan Z, Fan D
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Journal of agricultural and food chemistry 2023 Jun 21;71(24):9370-9380
Cathepsin K promotes the proliferation of hepatocellular carcinoma cells through induction of SIAH1 ubiquitination and degradation.
Zhang C, Liu Z, Wang X, Zhang B, Cui L, Hu Q, Hu B, Cao K, Shan W, Shi H, Wang R
iScience 2023 Jun 16;26(6):106852
iScience 2023 Jun 16;26(6):106852
HDAC inhibitor chidamide overcomes drug resistance in chronic myeloid leukemia with the T315i mutation through the Akt-autophagy pathway.
Yin L, Zhang Q, Xie S, Cheng Z, Li R, Zhu H, Yu Q, Yuan H, Wang C, Peng H, Zhang G
Human cell 2023 Jul;36(4):1564-1577
Human cell 2023 Jul;36(4):1564-1577
CRIP1 supports the growth and migration of AML-M5 subtype cells by activating Wnt/β-catenin pathway.
Deng X, Zeng Y, Qiu X, Zhong M, Xiong X, Luo M, Zhang J, Chen X
Leukemia research 2023 Jul;130:107312
Leukemia research 2023 Jul;130:107312
Targeting L-Selectin Lymphocytes to Deliver Immunosuppressive Drug in Lymph Nodes for Durable Multiple Sclerosis Treatment.
Zhao Y, Zhang J, Cheng X, Huang W, Shen S, Wu S, Huang Y, Nie G, Wang H, Qiu W
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2300738
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2023 Jul;10(20):e2300738
LHPP suppresses proliferation, migration, and invasion in hepatocellular carcinoma and pancreatic cancer by inhibiting EGFR signaling pathway.
Zhu H, Song C, Li J, Liu Q, Liu M, Fu L
Medical oncology (Northwood, London, England) 2023 Jul 31;40(9):257
Medical oncology (Northwood, London, England) 2023 Jul 31;40(9):257
MAT as a promising therapeutic strategy against triple-negative breast cancer via inhibiting PI3K/AKT pathway.
Wei S, Zhang Y, Ma X, Yao Y, Zhou Q, Zhang W, Zhou C, Zhuang J
Scientific reports 2023 Jul 31;13(1):12351
Scientific reports 2023 Jul 31;13(1):12351
Serine protease PRSS56, a novel cancer-testis antigen activated by DNA hypomethylation, promotes colorectal and gastric cancer progression via PI3K/AKT axis.
Li D, Xia L, Huang P, Wang Z, Guo Q, Huang C, Leng W, Qin S
Cell & bioscience 2023 Jul 3;13(1):124
Cell & bioscience 2023 Jul 3;13(1):124
NVS-ZP7-4 inhibits hepatocellular carcinoma tumorigenesis and promotes apoptosis via PI3K/AKT signaling.
Tong Q, Yan D, Cao Y, Dong X, Abula Y, Yang H, Kong P, Yi M
Scientific reports 2023 Jul 21;13(1):11795
Scientific reports 2023 Jul 21;13(1):11795
Lysophosphatidic acid is associated with oocyte maturation by enhancing autophagy via PI3K-AKT-mTOR signaling pathway in granulosa cells.
Liu J, Wang C
Journal of ovarian research 2023 Jul 11;16(1):137
Journal of ovarian research 2023 Jul 11;16(1):137
AFP deletion leads to anti-tumorigenic but pro-metastatic roles in liver cancers with concomitant CTNNB1 mutations.
Xu Y, Zhang X, Zhang R, Sun Y, Liu J, Luo C, Yang J, Fang W, Guo Q, Wei L
Cancer letters 2023 Jul 10;566:216240
Cancer letters 2023 Jul 10;566:216240
ATAXIA TELANGIECTASIA MUTATED PROTECTS AGAINST LIPOPOLYSACCARIDE-INDUCED BLOOD-BRAIN BARRIER DISRUPTION BY REGULATING ATK/DRP1-MEDIATED MITOCHONDRIAL HOMEOSTASIS.
Luo S, Lyu Z, Ge L, Li Y, Liu Y, Yuan Y, Zhao R, Huang L, Zhao J, Huang H, Luo Y
Shock (Augusta, Ga.) 2023 Jul 1;60(1):100-109
Shock (Augusta, Ga.) 2023 Jul 1;60(1):100-109
Biochemical and clinical effects of RPS20 expression in renal clear cell carcinoma.
Shen C, Chen Z, Zhang Y, Xu W, Peng R, Jiang J, Zuo W, Fan Y, Zheng B
Oncology reports 2023 Jan;49(1)
Oncology reports 2023 Jan;49(1)
Effect of transmembrane protein 100 on prostate cancer progression by regulating SCNN1D through the FAK/PI3K/AKT pathway.
Ye Z, Xia Y, Li L, Li B, Chen W, Han S, Zhou X, Chen L, Yu W, Ruan Y, Cheng F
Translational oncology 2023 Jan;27:101578
Translational oncology 2023 Jan;27:101578
The deubiquitinase OTUD1 noncanonically suppresses Akt activation through its N-terminal intrinsically disordered region.
Fan G, Wang F, Chen Y, Zheng Q, Xiong J, Lv Q, Wu K, Xiong J, Wei L, Li D, Zhang J, Zhang W, Li F
Cell reports 2023 Jan 31;42(1):111916
Cell reports 2023 Jan 31;42(1):111916
Promotion of the genipin crosslinked chitosan-fiber hydrogel loaded with sustained release of clemastine fumarate in diabetic wound repair.
Zuo R, Shi J, Jiang S, Chu M, Wang Q, Kong L, Kang Q, Guo Y, Guan J
International journal of biological macromolecules 2023 Jan 31;226:900-914
International journal of biological macromolecules 2023 Jan 31;226:900-914
Cancer-associated fibroblast-secreted IGFBP7 promotes gastric cancer by enhancing tumor associated macrophage infiltration via FGF2/FGFR1/PI3K/AKT axis.
Li D, Xia L, Huang P, Wang Z, Guo Q, Huang C, Leng W, Qin S
Cell death discovery 2023 Jan 21;9(1):17
Cell death discovery 2023 Jan 21;9(1):17
Annexin A2 promotes angiogenesis after ischemic stroke via annexin A2 receptor - AKT/ERK pathways.
Lin H, Li W, Shen Z, Bei Y, Wei T, Yu Z, Dai Y, Dai H
Neuroscience letters 2023 Jan 1;792:136941
Neuroscience letters 2023 Jan 1;792:136941
Aerobic exercise ameliorates insulin resistance in C57BL/6 J mice via activating Sestrin3.
Han X, Yang Y, Liu S, Niu Y, Shao H, Fu L
Biochimica et biophysica acta. Molecular basis of disease 2023 Jan 1;1869(1):166568
Biochimica et biophysica acta. Molecular basis of disease 2023 Jan 1;1869(1):166568
Protective role of cezanne in doxorubicin-induced cardiotoxicity by inhibiting autophagy, apoptosis and oxidative stress.
Zhang J, Zha Y, Jiao Y, Li Y, Zhang S
Toxicology 2023 Feb;485:153426
Toxicology 2023 Feb;485:153426
Adiponectin receptor agonist AdipoRon modulates human and mouse platelet function.
Zhou XH, Cheng ZP, Lu M, Lin WY, Luo LL, Ming ZY, Hu Y
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Acta pharmacologica Sinica 2023 Feb;44(2):356-366
Bone marrow mesenchymal stem cells repair hexavalent chromium-induced testicular injury by regulating autophagy and ferroptosis mediated by the AKT/mTOR pathway in rats.
Zhuge R, Li Z, He C, Ma W, Yan J, Xue Q, Wang R, Liu Y, Lu R, Du H, Yin F, Guo L
Environmental toxicology 2023 Feb;38(2):289-299
Environmental toxicology 2023 Feb;38(2):289-299
Expression of glucose transporter-1 in follicular lymphoma affected tumor-infiltrating immunocytes and was related to progression of disease within 24 months.
Deng Y, Ma J, Zhao S, Yang M, Sun Y, Zhang Q
Translational oncology 2023 Feb;28:101614
Translational oncology 2023 Feb;28:101614
Exploration the role of INHBA in Hu sheep granulosa cells using RNA-Seq.
Bao Y, Li X, El-Samahy MA, Yang H, Wang Z, Yang F, Yao X, Wang F
Theriogenology 2023 Feb;197:198-208
Theriogenology 2023 Feb;197:198-208
Saxagliptin alleviates erectile dysfunction through increasing stromal cell-derived factor-1 in diabetes mellitus.
Sun T, Xu W, Wang J, Wang T, Wang S, Liu K, Liu J
Andrology 2023 Feb;11(2):295-306
Andrology 2023 Feb;11(2):295-306
Study on the mechanism of aging-related erectile dysfunction based on bioinformatics and experimental verification.
Sun T, Liu Y, Chen Y, Xu W, Wang T, Liu K, Liu J
Translational andrology and urology 2023 Feb 28;12(2):197-208
Translational andrology and urology 2023 Feb 28;12(2):197-208
The protective effect of the mitochondrial-derived peptide MOTS-c on LPS-induced septic cardiomyopathy.
Wu J, Xiao D, Yu K, Shalamu K, He B, Zhang M
Acta biochimica et biophysica Sinica 2023 Feb 25;55(2):285-294
Acta biochimica et biophysica Sinica 2023 Feb 25;55(2):285-294
Glioblastoma upregulates SUMOylation of hnRNP A2/B1 to eliminate the tumor suppressor miR-204-3p, accelerating angiogenesis under hypoxia.
Guo Q, Fan Y, Wang Q, Li B, Qiu W, Qi Y, Pan Z, Zhang S, Zhao S, Yang K, Xu H, Li M, Gao Z, Xu J, Wang H, Wang S, Tang Q, Qiu J, Guo X, Deng L, Zhang P, Zhao R, Xue H, Wang C, Li G
Cell death & disease 2023 Feb 21;14(2):147
Cell death & disease 2023 Feb 21;14(2):147
Enterococcus faecalis promotes the progression of colorectal cancer via its metabolite: biliverdin.
Zhang L, Liu J, Deng M, Chen X, Jiang L, Zhang J, Tao L, Yu W, Qiu Y
Journal of translational medicine 2023 Feb 2;21(1):72
Journal of translational medicine 2023 Feb 2;21(1):72
Mulberroside A alleviates osteoarthritis via restoring impaired autophagy and suppressing MAPK/NF-κB/PI3K-AKT-mTOR signaling pathways.
Lu R, Wei Z, Wang Z, Xu S, Sun K, Cheng P, Huang X, You H, Guo F, Liang S, Chen AM
iScience 2023 Feb 17;26(2):105936
iScience 2023 Feb 17;26(2):105936
Deciphering the underlying wound healing mechanisms of Streptocaulon juventas (Lour.) Merr. by integrating network pharmacology, transcriptomics, and experimental validation.
Li Y, Zang J, Wang X, Feng X, Qiu F
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115890
Network pharmacology analysis combined with experimental validation to explore the therapeutic mechanism of Schisandra Chinensis Mixture on diabetic nephropathy.
Ma Y, Deng Y, Li N, Dong A, Li H, Chen S, Zhang S, Zhang M
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115768
Journal of ethnopharmacology 2023 Feb 10;302(Pt A):115768
PLCB1 Enhances Cell Migration and Invasion in Gastric Cancer Via Regulating Actin Cytoskeletal Remodeling and Epithelial-Mesenchymal Transition.
Wang Y, Tu Z, Zhao W, Wang L, Jiang J, Gu L, Li M, Jiang L, Wang Y, Bi Y
Biochemical genetics 2023 Dec;61(6):2618-2632
Biochemical genetics 2023 Dec;61(6):2618-2632
Loke zupa decoction attenuates bronchial EMT-mediated airway remodelling in chronic asthma through the PI3K-Akt/HIF-1α signaling pathway.
Liu J, Li L, Han X, Chen Y, Diao J
Pharmaceutical biology 2023 Dec;61(1):1332-1342
Pharmaceutical biology 2023 Dec;61(1):1332-1342
Molecular Targets and Mechanisms of Casein-Derived Tripeptides Ile-Pro-Pro and Val-Pro-Pro on Hepatic Glucose Metabolism.
Wang C, Zheng L, Zhao M
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18802-18814
Journal of agricultural and food chemistry 2023 Dec 6;71(48):18802-18814
Pi-Pa-Run-Fei-Tang alleviates lung injury by modulating IL-6/JAK2/STAT3/IL-17 and PI3K/AKT/NF-κB signaling pathway and balancing Th17 and Treg in murine model of OVA-induced asthma.
Jie XL, Luo ZR, Yu J, Tong ZR, Li QQ, Wu JH, Tao Y, Feng PS, Lan JP, Wang P
Journal of ethnopharmacology 2023 Dec 5;317:116719
Journal of ethnopharmacology 2023 Dec 5;317:116719
Targeting AKT induced Ferroptosis through FTO/YTHDF2-dependent GPX4 m6A methylation up-regulating and degradating in colorectal cancer.
Zhang G, Mi W, Wang C, Li J, Zhang Y, Liu N, Jiang M, Jia G, Wang F, Yang G, Zhang L, Wang J, Fu Y, Zhang Y
Cell death discovery 2023 Dec 15;9(1):457
Cell death discovery 2023 Dec 15;9(1):457
Thymosin β4 Exerts a Cytoprotective Function and Attenuates Liver Injury in Murine Hepatic Sinusoidal Obstruction Syndrome after Hematopoietic Stem Cell Transplantation.
Wang X, Zhou Y, Sun Q, Zhang Q, Zhou H, Zhang J, Du Y, Wang Y, Yuan K, Xu L, Zhang M, Yan D, Zeng L, Xu K, Sang W
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Transplantation and cellular therapy 2023 Aug;29(8):492.e1-492.e10
Profile of N6-methyladenosine of Pb-exposed neurons presents epitranscriptomic alterations in PI3K-AKT pathway-associated genes.
Ai S, Li D, Gu X, Xu Y, Wang Y, Wang HL, Chen XT
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2023 Aug;178:113821
Heterodimerization of cholecystokinin 1 and cholecystokinin 2 receptors in gallbladder cancer: a new mechanism for carcinogenesis.
Nigam J, Kazmi HR, Khare L, Srivastava M, Chandra A
Journal of cancer research and clinical oncology 2023 Aug;149(10):7069-7078
Journal of cancer research and clinical oncology 2023 Aug;149(10):7069-7078
Astragaloside IV protects LO2 cells from oxidative damage caused by radiation-induced bystander effect through Akt/Nrf2 pathway.
Wan D, Zhu Z, Zhou J, Deng Z, Lei P, Liu Q, Sun X, Huang B
Toxicology research 2023 Aug;12(4):635-647
Toxicology research 2023 Aug;12(4):635-647
Tumor-Associated Extracellular Microvesicles with Fluorine-Modified Carbohydrate Antigens Trigger a Stronger Antitumor Immune Response.
Mo J, Zou Y, Li BH, Li G, Zheng XJ, Liu Y, Ye XS
ACS applied materials & interfaces 2023 Aug 30;15(34):40201-40212
ACS applied materials & interfaces 2023 Aug 30;15(34):40201-40212
MiR-297 inhibits tumour progression of liver cancer by targeting PTBP3.
Lu N, Min J, Peng L, Huang S, Chai X, Wang S, Wang J
Cell death & disease 2023 Aug 26;14(8):564
Cell death & disease 2023 Aug 26;14(8):564
WITHDRAWN: Expression of Tmem41b and MMP13 associated with poor outcome in osteosarcomas.
Li GH, Liu X, Feng LJ, Zhang L
Neoplasma 2023 Aug 20;
Neoplasma 2023 Aug 20;
Aerobic Exercise Facilitates the Nuclear Translocation of SREBP2 by Activating AKT/SEC24D to Contribute Cholesterol Homeostasis for Improving Cognition in APP/PS1 Mice.
Hu Z, Yuan Y, Tong Z, Liao M, Yuan S, Wu W, Tang Y, Wang Y, Tang C, Liu W
International journal of molecular sciences 2023 Aug 16;24(16)
International journal of molecular sciences 2023 Aug 16;24(16)
Targeting phenylpyruvate restrains excessive NLRP3 inflammasome activation and pathological inflammation in diabetic wound healing.
Lv D, Cao X, Zhong L, Dong Y, Xu Z, Rong Y, Xu H, Wang Z, Yang H, Yin R, Chen M, Ke C, Hu Z, Deng W, Tang B
Cell reports. Medicine 2023 Aug 15;4(8):101129
Cell reports. Medicine 2023 Aug 15;4(8):101129
Intermittent fasting activates macrophage migration inhibitory factor and alleviates high-fat diet-induced nonalcoholic fatty liver disease.
Li D, Dun Y, Qi D, Ripley-Gonzalez JW, Dong J, Zhou N, Qiu L, Zhang J, Zeng T, You B, Liu S
Scientific reports 2023 Aug 11;13(1):13068
Scientific reports 2023 Aug 11;13(1):13068
Marein reduces lipid levels via modulating the PI3K/AKT/mTOR pathway to induce lipophagy.
Zhang PP, Zhuo BY, Duan ZW, Li X, Huang SL, Cao Q, Zhao T, Wei SL, Hu XH, Zhang Y
Journal of ethnopharmacology 2023 Aug 10;312:116523
Journal of ethnopharmacology 2023 Aug 10;312:116523
Saponin extract from Achyranthes bidentata Blume alleviates disuse-induced muscle atrophy through PI3K/Akt signaling pathway.
Shi Y, Zhang ZW, Du MM, Wu J, Li JX
Journal of ethnopharmacology 2023 Aug 10;312:116458
Journal of ethnopharmacology 2023 Aug 10;312:116458
Deletion of the tyrosine phosphatase Shp2 in cervical cancer cells promotes reprogramming of glutamine metabolism.
Gao X, Kang J, Li X, Chen C, Luo D
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22880
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2023 Apr;37(4):e22880
Kaempferol promotes melanogenesis and reduces oxidative stress in PIG1 normal human skin melanocytes.
Xie Y, Mei X, Shi W
Journal of cellular and molecular medicine 2023 Apr;27(7):982-990
Journal of cellular and molecular medicine 2023 Apr;27(7):982-990
CircHGS enhances the progression of bladder cancer by regulating the miR-513a-5p/VEGFC axis and activating the AKT/mTOR signaling pathway.
Zhu Y, Zuo L, Xiong H, Li S, Chen R, Liu H
Cell cycle (Georgetown, Tex.) 2023 Apr;22(8):919-938
Cell cycle (Georgetown, Tex.) 2023 Apr;22(8):919-938
ARID1B blocks methionine-stimulated mTOR activation to inhibit milk fat and protein synthesis in and proliferation of mouse mammary epithelial cells.
Lin G, Qi H, Guo X, Wang W, Zhang M, Gao X
The Journal of nutritional biochemistry 2023 Apr;114:109274
The Journal of nutritional biochemistry 2023 Apr;114:109274
Integrated network pharmacology and experimental verification to explore the molecular mechanism of Jingxin Zhidong formula for treating Tic disorder.
Tian X, Ou G, Hu S, Wang C, Han F, Gao L
Journal of ethnopharmacology 2023 Apr 6;305:116114
Journal of ethnopharmacology 2023 Apr 6;305:116114
Anti-inflammatory effect of Irisin on LPS-stimulated macrophages through inhibition of MAPK pathway.
Ma Y, Du Y, Yang J, He Q, Wang H, Lin X
Physiological research 2023 Apr 30;72(2):235-249
Physiological research 2023 Apr 30;72(2):235-249
Brassicasterol inhibits hepatitis B virus-associated hepatocellular carcinoma development via suppression of AKT signaling pathway.
Zeng J, Wu J, Pang S, Wang F, Yu X, Zhang S, Zeng J, Yan J, Lian J
Infectious agents and cancer 2023 Apr 20;18(1):22
Infectious agents and cancer 2023 Apr 20;18(1):22
Xiaoyaosan ameliorates depressive-like behavior and susceptibility to glucose intolerance in rat: involvement of LepR-STAT3/PI3K pathway in hypothalamic arcuate nucleus.
Qiu W, Wu Q, Zhang K, Da X, Tang K, Yuan N, Deng L, Wu M, Zhang Y, Quan J, Ma Q, Li X, Chen J
BMC complementary medicine and therapies 2023 Apr 12;23(1):116
BMC complementary medicine and therapies 2023 Apr 12;23(1):116
Momordica. charantia-Derived Extracellular Vesicles-Like Nanovesicles Protect Cardiomyocytes Against Radiation Injury via Attenuating DNA Damage and Mitochondria Dysfunction.
Cui WW, Ye C, Wang KX, Yang X, Zhu PY, Hu K, Lan T, Huang LY, Wang W, Gu B, Yan C, Ma P, Qi SH, Luo L
Frontiers in cardiovascular medicine 2022;9:864188
Frontiers in cardiovascular medicine 2022;9:864188
Molecular and Cellular Response of the Myocardium (H9C2 Cells) Towards Hypoxia and HIF-1α Inhibition.
Osuru HP, Lavallee M, Thiele RH
Frontiers in cardiovascular medicine 2022;9:711421
Frontiers in cardiovascular medicine 2022;9:711421
Network Pharmacology-Based Prediction and Verification of the Potential Targets of Pinoresinol Diglucoside for OA Treatment.
Lou H, Zhang Y, Fang J, Jin Y
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9733742
Guanxinping Tablets Inhibit ET-1-Induced Proliferation and Migration of MOVAS by Suppressing Activated PI3K/Akt/NF-κB Signaling Cascade.
Wu YY, Huang YL, Dai B, Liu JW, Han X
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9485463
Evidence-based complementary and alternative medicine : eCAM 2022;2022:9485463
Brevilin A Inhibits VEGF-Induced Angiogenesis through ROS-Dependent Mitochondrial Dysfunction.
Wei B, Hao Z, Zheng H, Qin Y, Zhao F, Shi L
Oxidative medicine and cellular longevity 2022;2022:5888636
Oxidative medicine and cellular longevity 2022;2022:5888636
Prediction of the Mechanism of Shaoyao Gancao Decoction in the Treatment of Alopecia Areata by Network Pharmacology and Its Preliminary Verification Study.
Lv S, Wang L, Duan Y, Huang D, Yang D
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5764107
Evidence-based complementary and alternative medicine : eCAM 2022;2022:5764107
Targeting Inhibition of Accumulation and Function of Myeloid-Derived Suppressor Cells by Artemisinin via PI3K/AKT, mTOR, and MAPK Pathways Enhances Anti-PD-L1 Immunotherapy in Melanoma and Liver Tumors.
Zhang M, Wang L, Liu W, Wang T, De Sanctis F, Zhu L, Zhang G, Cheng J, Cao Q, Zhou J, Tagliabue A, Bronte V, Yan D, Wan X, Yu G
Journal of immunology research 2022;2022:2253436
Journal of immunology research 2022;2022:2253436
Aerobic Exercise Regulates Apoptosis through the PI3K/Akt/GSK-3β Signaling Pathway to Improve Cognitive Impairment in Alzheimer's Disease Mice.
Peng Y, Chi R, Liu G, Tian W, Zhang J, Zhang R
Neural plasticity 2022;2022:1500710
Neural plasticity 2022;2022:1500710
Xiao-Chai-Hu Decoction Ameliorates Poly (I:C)-Induced Viral Pneumonia through Inhibiting Inflammatory Response and Modulating Serum Metabolism.
Chen F, Qu F, Jia Y, Wang C, Yu Y, Liao J, Lin M, Chen F, Sun Z
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1240242
Evidence-based complementary and alternative medicine : eCAM 2022;2022:1240242
TAB2 Promotes the Biological Functions of Head and Neck Squamous Cell Carcinoma Cells via EMT and PI3K Pathway.
Liu H, Zhang H, Fan H, Tang S, Weng J
Disease markers 2022;2022:1217918
Disease markers 2022;2022:1217918
Mechanism of Abelmoschus manihot L. in the Treatment of Contrast-Induced Nephropathy on the Basis of Network Pharmacology Analysis.
Xu Z, Qian L, Niu R, Wang Y, Yang Y, Liu C, Lin X
Frontiers in nephrology 2022;2:834513
Frontiers in nephrology 2022;2:834513
Human CPTP promotes growth and metastasis via sphingolipid metabolite ceramide and PI4KA/AKT signaling in pancreatic cancer cells.
Zhang Y, Ji S, Zhang X, Lu M, Hu Y, Han Y, Shui G, Lam SM, Zou X
International journal of biological sciences 2022;18(13):4963-4983
International journal of biological sciences 2022;18(13):4963-4983
Exploration of the Effect and Potential Mechanism of Echinacoside Against Endometrial Cancer Based on Network Pharmacology and in vitro Experimental Verification.
Shu W, Wang Z, Zhao R, Shi R, Zhang J, Zhang W, Wang H
Drug design, development and therapy 2022;16:1847-1863
Drug design, development and therapy 2022;16:1847-1863
Chitosan/Sodium Alginate/Velvet Antler Blood Peptides Hydrogel Promotes Diabetic Wound Healing via Regulating Angiogenesis, Inflammatory Response and Skin Flora.
Hao M, Ding C, Sun S, Peng X, Liu W
Journal of inflammation research 2022;15:4921-4938
Journal of inflammation research 2022;15:4921-4938
Effect of β-hydroxybutyrate on behavioral alterations, molecular and morphological changes in CNS of multiple sclerosis mouse model.
Sun W, Wen M, Liu M, Wang Q, Liu Q, Li L, Siebert HC, Loers G, Zhang R, Zhang N
Frontiers in aging neuroscience 2022;14:1075161
Frontiers in aging neuroscience 2022;14:1075161
Taurine Ameliorates Apoptosis via AKT Pathway in the Kidney of Diabetic Rats.
Li S, Wang D, Zhang M, Zhang C, Piao F
Advances in experimental medicine and biology 2022;1370:227-233
Advances in experimental medicine and biology 2022;1370:227-233
Honokiol improves depression-like behaviors in rats by HIF-1α- VEGF signaling pathway activation.
Fan XX, Sun WY, Li Y, Tang Q, Li LN, Yu X, Wang SY, Fan AR, Xu XQ, Chang HS
Frontiers in pharmacology 2022;13:968124
Frontiers in pharmacology 2022;13:968124
Network pharmacology and experimental analysis to reveal the mechanism of Dan-Shen-Yin against endothelial to mesenchymal transition in atherosclerosis.
Hong M, Wu Y, Zhang H, Gu J, Chen J, Guan Y, Qin X, Li Y, Cao J
Frontiers in pharmacology 2022;13:946193
Frontiers in pharmacology 2022;13:946193
Puffball spores improve wound healing in a diabetic rat model.
He T, Sun P, Liu B, Wan S, Fang P, Chen J, Huang G, Min W
Frontiers in endocrinology 2022;13:942549
Frontiers in endocrinology 2022;13:942549
Mechanism of Tripterygium wilfordii Hook.F.- Trichosanthes kirilowii Maxim decoction in treatment of diabetic kidney disease based on network pharmacology and molecular docking.
Lu L, Peng J, Wan P, Peng H, Lu J, Xiong G
Frontiers in pharmacology 2022;13:940773
Frontiers in pharmacology 2022;13:940773
Hua-Tan-Sheng-Jing Decoction Treats Obesity With Oligoasthenozoospermia by Up-Regulating the PI3K-AKT and Down-Regulating the JNK MAPK Signaling Pathways: At the Crossroad of Obesity and Oligoasthenozoospermia.
Dong Y, Zheng Y, Zhu L, Li T, Guan Y, Zhao S, Wang Q, Wang J, Li L
Frontiers in pharmacology 2022;13:896434
Frontiers in pharmacology 2022;13:896434
Network Pharmacology-Based Strategy to Identify the Pharmacological Mechanisms of Pulsatilla Decoction against Crohn's Disease.
Liu J, Zhang L, Wang Z, Chen S, Feng S, He Y, Zhang S
Frontiers in pharmacology 2022;13:844685
Frontiers in pharmacology 2022;13:844685
Shexiang Tongxin Dropping Pills Promote Macrophage Polarization-Induced Angiogenesis Against Coronary Microvascular Dysfunction via PI3K/Akt/mTORC1 Pathway.
Lu X, Yao J, Li C, Cui L, Liu Y, Liu X, Wang G, Dong J, Deng Q, Hu Y, Guo D, Wang W, Li C
Frontiers in pharmacology 2022;13:840521
Frontiers in pharmacology 2022;13:840521
Therapeutic Potential of Astragaloside IV Against Adriamycin-Induced Renal Damage in Rats via Ferroptosis.
Qin LY, Guan P, Wang JX, Chen Y, Zhao YS, Yang SC, Guo YJ, Wang N, Ji ES
Frontiers in pharmacology 2022;13:812594
Frontiers in pharmacology 2022;13:812594
Neuregulin-1β increases glucose uptake and promotes GLUT4 translocation in palmitate-treated C2C12 myotubes by activating PI3K/AKT signaling pathway.
Yu M, Wu S, Gong C, Chen L
Frontiers in pharmacology 2022;13:1066279
Frontiers in pharmacology 2022;13:1066279
Oroxin B alleviates osteoarthritis through anti-inflammation and inhibition of PI3K/AKT/mTOR signaling pathway and enhancement of autophagy.
Lu R, He Z, Zhang W, Wang Y, Cheng P, Lv Z, Yuan X, Guo F, You H, Chen AM, Hu W
Frontiers in endocrinology 2022;13:1060721
Frontiers in endocrinology 2022;13:1060721
Depletion of PARP10 inhibits the growth and metastatic potential of oral squamous cell carcinoma.
Zhou Z, Wei B, Liu Y, Liu T, Zeng S, Gan J, Qi G
Frontiers in genetics 2022;13:1035638
Frontiers in genetics 2022;13:1035638
Interleukin 33-mediated inhibition of A-type K(+) channels induces sensory neuronal hyperexcitability and nociceptive behaviors in mice.
Wang Y, Wang X, Qi R, Lu Y, Tao Y, Jiang D, Sun Y, Jiang X, Liu C, Zhang Y, Tao J
Theranostics 2022;12(5):2232-2247
Theranostics 2022;12(5):2232-2247
Synergistic effects of nab-PTX and anti-PD-1 antibody combination against lung cancer by regulating the Pi3K/AKT pathway through the Serpinc1 gene.
Zhang J, Tang Z, Guo X, Wang Y, Zhou Y, Cai W
Frontiers in oncology 2022;12:933646
Frontiers in oncology 2022;12:933646
FNDC5 Causes Resistance to Sorafenib by Activating the PI3K/Akt/Nrf2 Pathway in Hepatocellular Carcinoma Cells.
Liu H, Zhao L, Wang M, Yang K, Jin Z, Zhao C, Shi G
Frontiers in oncology 2022;12:852095
Frontiers in oncology 2022;12:852095
HRK inhibits colorectal cancer cells proliferation by suppressing the PI3K/AKT/mTOR pathway.
Wang H, Chen Y, Yuan Q, Chen L, Dai P, Li X
Frontiers in oncology 2022;12:1053510
Frontiers in oncology 2022;12:1053510
HIF-1/2α-Activated RNF146 Enhances the Proliferation and Glycolysis of Hepatocellular Carcinoma Cells via the PTEN/AKT/mTOR Pathway.
Shen G, Wang H, Zhu N, Lu Q, Liu J, Xu Q, Huang D
Frontiers in cell and developmental biology 2022;10:893888
Frontiers in cell and developmental biology 2022;10:893888
Icariside II suppresses the tumorigenesis and development of ovarian cancer by regulating miR-144-3p/IGF2R axis.
Yuan D, Guo T, Qian H, Ge H, Zhao Y, Huang A, Wang X, Cao X, Zhu D, He C, Yu H
Drug development research 2022 Sep;83(6):1383-1393
Drug development research 2022 Sep;83(6):1383-1393
Sodium butyrate attenuates bovine mammary epithelial cell injury by inhibiting the formation of neutrophil extracellular traps.
Li Y, Liu J, Cui Y, Cao Y, Xu P, Kan X, Guo W, Fu S
International immunopharmacology 2022 Sep;110:109009
International immunopharmacology 2022 Sep;110:109009
Magnoflorine attenuates inflammatory responses in RA by regulating the PI3K/Akt/NF-κB and Keap1-Nrf2/HO-1 signalling pathways in vivo and in vitro.
Shen Y, Fan X, Qu Y, Tang M, Huang Y, Peng Y, Fu Q
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Sep;104:154339
TRAF4 Promotes the Proliferation of Glioblastoma by Stabilizing SETDB1 to Activate the AKT Pathway.
Gu H, Zhu S, Peng C, Wei Z, Shen Y, Yuan C, Yang H, Cui H, Yang L
International journal of molecular sciences 2022 Sep 5;23(17)
International journal of molecular sciences 2022 Sep 5;23(17)
CLDN4 promotes growth of acute myeloid leukemia cells via regulating AKT and ERK1/2 signaling.
Hao S, Yang C, Song P, Shi H, Zou Y, Chen M, Wu X, Yin Y, Yu Z, Zhu W, Li M
Biochemical and biophysical research communications 2022 Sep 3;619:137-143
Biochemical and biophysical research communications 2022 Sep 3;619:137-143
Exploring Active Ingredients, Beneficial Effects, and Potential Mechanism of Allium tenuissimum L. Flower for Treating T2DM Mice Based on Network Pharmacology and Gut Microbiota.
Zhang SS, Hou YF, Liu SJ, Guo S, Ho CT, Bai NS
Nutrients 2022 Sep 25;14(19)
Nutrients 2022 Sep 25;14(19)
MED16 Promotes Tumour Progression and Tamoxifen Sensitivity by Modulating Autophagy through the mTOR Signalling Pathway in ER-Positive Breast Cancer.
Li H, Li K, Shu D, Shen M, Tan Z, Zhang W, Pu D, Tan W, Tang Z, Jin A, Liu S
Life (Basel, Switzerland) 2022 Sep 20;12(10)
Life (Basel, Switzerland) 2022 Sep 20;12(10)
KCNJ14 knockdown significantly inhibited the proliferation and migration of colorectal cells.
Li B, Ge N, Pan Z, Hou C, Xie K, Wang D, Liu J, Wan J, Deng F, Li M, Luo S
BMC medical genomics 2022 Sep 13;15(1):194
BMC medical genomics 2022 Sep 13;15(1):194
Impact of Resolvin D1 on the inflammatory phenotype of periodontal ligament cell response to hypoxia.
Cai J, Liu J, Yan J, Lu X, Wang X, Li S, Mustafa K, Wang H, Xue Y, Mustafa M, Kantarci A, Xing Z
Journal of periodontal research 2022 Oct;57(5):1034-1042
Journal of periodontal research 2022 Oct;57(5):1034-1042
MiR-574-5p promotes cell proliferation by negatively regulating small C-terminal domain phosphatase 1 in esophageal squamous cell carcinoma.
Zhao C, Liu J, Xu Y, Guo J, Wang L, Chen L, Xu L, Dong G, Zheng W, Li Z, Cai H, Li S
Iranian journal of basic medical sciences 2022 Oct;25(10):1243-1250
Iranian journal of basic medical sciences 2022 Oct;25(10):1243-1250
Identification of a five m6A-relevant mRNAs signature and risk score for the prognostication of gastric cancer.
Yin L, Feng S, Sun Y, Jiang Y, Tang C, Sun D
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
Journal of gastrointestinal oncology 2022 Oct;13(5):2234-2248
A ROS-Responsive Liposomal Composite Hydrogel Integrating Improved Mitochondrial Function and Pro-Angiogenesis for Efficient Treatment of Myocardial Infarction.
Zheng Z, Lei C, Liu H, Jiang M, Zhou Z, Zhao Y, Yu CY, Wei H
Advanced healthcare materials 2022 Oct;11(19):e2200990
Advanced healthcare materials 2022 Oct;11(19):e2200990
Ginseng under forest exerts stronger anti-aging effects compared to garden ginseng probably via regulating PI3K/AKT/mTOR pathway, SIRT1/NF-κB pathway and intestinal flora.
Hao M, Ding C, Peng X, Chen H, Dong L, Zhang Y, Chen X, Liu W, Luo Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Oct;105:154365
The GBM Tumor Microenvironment as a Modulator of Therapy Response: ADAM8 Causes Tumor Infiltration of Tams through HB-EGF/EGFR-Mediated CCL2 Expression and Overcomes TMZ Chemosensitization in Glioblastoma.
Liu X, Huang Y, Qi Y, Wu S, Hu F, Wang J, Shu K, Zhang H, Bartsch JW, Nimsky C, Dong F, Lei T
Cancers 2022 Oct 7;14(19)
Cancers 2022 Oct 7;14(19)
Protein disulfide isomerase blocks the interaction of LC3II-PHB2 and promotes mTOR signaling to regulate autophagy and radio/chemo-sensitivity.
Wang R, Shang Y, Chen B, Xu F, Zhang J, Zhang Z, Zhao X, Wan X, Xu A, Wu L, Zhao G
Cell death & disease 2022 Oct 6;13(10):851
Cell death & disease 2022 Oct 6;13(10):851
Inhibition of SRPK1, a key splicing regulator, exhibits antitumor and chemotherapeutic-sensitizing effects on extranodal NK/T-cell lymphoma cells.
He C, Liu B, Wang HY, Wu L, Zhao G, Huang C, Liu Y, Shan B, Liu L
BMC cancer 2022 Oct 27;22(1):1100
BMC cancer 2022 Oct 27;22(1):1100
MCM2 promotes the stemness and sorafenib resistance of hepatocellular carcinoma cells via hippo signaling.
Zhou X, Luo J, Xie H, Wei Z, Li T, Liu J, Liao X, Zhu G, Peng T
Cell death discovery 2022 Oct 15;8(1):418
Cell death discovery 2022 Oct 15;8(1):418
Design, Synthesis and Evaluation of Novel 1,4-Disubstituted Piperazine-2,5-dione Derivatives as Antioxidants against H(2)O(2)-Induced Oxidative Injury via the IL-6/Nrf2 Loop Pathway.
Xiong L, Wu H, Zhong T, Luo F, Li Q, Li M, Fan Y
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Antioxidants (Basel, Switzerland) 2022 Oct 12;11(10)
Siah1 promotes the proliferation of NSCLC cells through ubiquitinating and stabilizing Notch1.
Liu Y, Li Q, Geng L, Zhou X, Zhou X, Dong Y, Zhang Y
Experimental cell research 2022 Oct 1;419(1):113305
Experimental cell research 2022 Oct 1;419(1):113305
Kaempferol prevents angiogenesis of rat intestinal microvascular endothelial cells induced by LPS and TNF-α via inhibiting VEGF/Akt/p38 signaling pathways and maintaining gut-vascular barrier integrity.
Yu R, Zhong J, Zhou Q, Ren W, Liu Z, Bian Y
Chemico-biological interactions 2022 Oct 1;366:110135
Chemico-biological interactions 2022 Oct 1;366:110135
CCT4 knockdown enhances the sensitivity of cisplatin by inhibiting glycolysis in human esophageal squamous cell carcinomas.
Fang J, Ma Y, Li Y, Li J, Zhang X, Han X, Ma S, Guan F
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
Molecular carcinogenesis 2022 Nov;61(11):1043-1055
An oleanolic acid derivative, K73-03, inhibits pancreatic cancer cells proliferation in vitro and in vivo via blocking EGFR/Akt pathway.
Zhou Z, Dong Y, Li N, Niu M, Wang S, Zhou Y, Sun Z, Chu P, Tang Z
Cell biology international 2022 Nov;46(11):1801-1813
Cell biology international 2022 Nov;46(11):1801-1813
AGR2-induced cholesterol synthesis drives lovastatin resistance that is overcome by combination therapy with allicin.
Sheng N, Wang YQ, Wang CF, Jia MQ, Niu HM, Lu QQ, Wang YN, Feng D, Zheng XX, Yuan HQ
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916
Acta pharmacologica Sinica 2022 Nov;43(11):2905-2916
Total flavonoids from the dried root of Tetrastigma hemsleyanum Diels et Gilg inhibit colorectal cancer growth through PI3K/AKT/mTOR signaling pathway.
Zhai Y, Sun J, Sun C, Zhao H, Li X, Yao J, Su J, Xu X, Xu X, Hu J, Daglia M, Han B, Kai G
Phytotherapy research : PTR 2022 Nov;36(11):4263-4277
Phytotherapy research : PTR 2022 Nov;36(11):4263-4277
Legumain affects the PI3K/AKT tumor progression pathway in retinoblastoma.
Tang Q, Xu F, Lin J, Zhang C, Liu X, Dong L, Zhao J, Zhu L, Lin T
Experimental eye research 2022 Nov;224:109221
Experimental eye research 2022 Nov;224:109221
Maizediterpene D from the roots of Zea mays L. alleviates hydrogen peroxide induced oxidative stress and improves cell survival by activation of TrkB/IGF-1R crosstalk pathways.
Fan Y, Wu H, Xiong L, Luo F, Li Q, Wang D, Zhong T
Fitoterapia 2022 Nov;163:105314
Fitoterapia 2022 Nov;163:105314
Exploring the Effective Components and Mechanism of Action of Japanese Ardisia in the Treatment of Autoimmune Hepatitis Based on Network Pharmacology and Experimental Verification.
Fu T, Chen Y, Li J, Zhu P, He H, Zhang W, Yung KKL, Wu W
Pharmaceuticals (Basel, Switzerland) 2022 Nov 24;15(12)
Pharmaceuticals (Basel, Switzerland) 2022 Nov 24;15(12)
Taurine attenuates neuronal ferroptosis by regulating GABA(B)/AKT/GSK3β/β-catenin pathway after subarachnoid hemorrhage.
Liu C, He P, Guo Y, Tian Q, Wang J, Wang G, Zhang Z, Li M
Free radical biology & medicine 2022 Nov 20;193(Pt 2):795-807
Free radical biology & medicine 2022 Nov 20;193(Pt 2):795-807
Transformer 2 alpha homolog is a downstream gene of hypoxia-inducible factor 1 subunit alpha and is involved in the progression of pancreatic cancer.
Cao W, Lei S, Zeng Z, Xiao C, Sun B, Xie P, Li Y, Luo D, Yu W
Bioengineered 2022 May;13(5):13238-13251
Bioengineered 2022 May;13(5):13238-13251
Circadian Period 2 (Per2) downregulate inhibitor of differentiation 3 (Id3) expression via PTEN/AKT/Smad5 axis to inhibits glioma cell proliferation.
Zhang Y, Hu X, Li H, Yao J, Yang P, Lan Y, Xia H
Bioengineered 2022 May;13(5):12350-12364
Bioengineered 2022 May;13(5):12350-12364
Protective Effect of Resveratrol on Immortalized Duck Intestinal Epithelial Cells Exposed to H(2)O(2).
Zhou N, Tian Y, Wu H, Cao Y, Li R, Zou K, Xu W, Lu L
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Molecules (Basel, Switzerland) 2022 May 31;27(11)
Ginsenoside Rg3 ameliorates myocardial glucose metabolism and insulin resistance via activating the AMPK signaling pathway.
Ni J, Liu Z, Jiang M, Li L, Deng J, Wang X, Su J, Zhu Y, He F, Mao J, Gao X, Fan G
Journal of ginseng research 2022 Mar;46(2):235-247
Journal of ginseng research 2022 Mar;46(2):235-247
Vitamin D3 promotes autophagy in THP-1 cells infected with Mycobacterium tuberculosis.
Wu Y, Lin X, Song F, Xue D, Wang Y
Experimental and therapeutic medicine 2022 Mar;23(3):240
Experimental and therapeutic medicine 2022 Mar;23(3):240
Downregulation of NCL attenuates tumor formation and growth in HeLa cells by targeting the PI3K/AKT pathway.
Ying J, Pan R, Tang Z, Zhu J, Ren P, Lou Y, Zhang E, Huang D, Hu P, Li D, Bao Q, Li P
Cancer medicine 2022 Mar;11(6):1454-1464
Cancer medicine 2022 Mar;11(6):1454-1464
Fucoidan protects the pancreas and improves glucose metabolism through inhibiting inflammation and endoplasmic reticulum stress in T2DM rats.
Liu Y, Huang H, Xu Z, Xue Y, Zhang D, Zhang Y, Li W, Li X
Food & function 2022 Mar 7;13(5):2693-2709
Food & function 2022 Mar 7;13(5):2693-2709
Ascorbic acid 2-glucoside preconditioning enhances the ability of bone marrow mesenchymal stem cells in promoting wound healing.
Yi Y, Wu M, Zhou X, Xiong M, Tan Y, Yu H, Liu Z, Wu Y, Zhang Q
Stem cell research & therapy 2022 Mar 21;13(1):119
Stem cell research & therapy 2022 Mar 21;13(1):119
COL11A1-Driven Epithelial-Mesenchymal Transition and Stemness of Pancreatic Cancer Cells Induce Cell Migration and Invasion by Modulating the AKT/GSK-3β/Snail Pathway.
Wang H, Zhou H, Ni H, Shen X
Biomolecules 2022 Mar 2;12(3)
Biomolecules 2022 Mar 2;12(3)
Fucoidan ameliorates glucose metabolism by the improvement of intestinal barrier and inflammatory damage in type 2 diabetic rats.
Liu Y, Xu Z, Huang H, Xue Y, Zhang D, Zhang Y, Li W, Li X
International journal of biological macromolecules 2022 Mar 15;201:616-629
International journal of biological macromolecules 2022 Mar 15;201:616-629
Protection of pancreatic β-cell by phosphocreatine through mitochondrial improvement via the regulation of dual AKT/IRS-1/GSK-3β and STAT3/Cyp-D signaling pathways.
Wang H, Ai J, Shopit A, Niu M, Ahmed N, Tesfaldet T, Tang Z, Li X, Jamalat Y, Chu P, Peng J, Ma X, Qaed E, Han G, Zhang W, Wang J, Tang Z
Cell biology and toxicology 2022 Jun;38(3):531-551
Cell biology and toxicology 2022 Jun;38(3):531-551
Inhibition of FAM83D displays antitumor effects in glioblastoma via down-regulation of the AKT/Wnt/β-catenin pathway.
Wang J, Quan Y, Lv J, Gong S, Ren P
Environmental toxicology 2022 Jun;37(6):1343-1356
Environmental toxicology 2022 Jun;37(6):1343-1356
Rutin-activated adipose tissue thermogenesis is correlated with increased intestinal short-chain fatty acid levels.
Cheng L, Shi L, He C, Wang C, Lv Y, Li H, An Y, Dai H, Duan Y, Zhang H, Huang Y, Fu W, Meng Y, Zhao B
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Phytotherapy research : PTR 2022 Jun;36(6):2495-2510
Cyclo-(Phe-Tyr) as a novel cyclic dipeptide compound alleviates ischemic/reperfusion brain injury via JUNB/JNK/NF-κB and SOX5/PI3K/AKT pathways.
Cai J, Liang J, Zhang Y, Shen L, Lin H, Hu T, Zhan S, Xie M, Liang S, Xian M, Wang S
Pharmacological research 2022 Jun;180:106230
Pharmacological research 2022 Jun;180:106230
Effects of 2-dodecyl-6-methoxycyclohexa-2,5-diene-1,4-dione on autophagy and the PI3K/AKT/mTOR signaling pathway in human cholangiocarcinoma QBC939 cells.
He Y, Li Y, Liang T, Mo S, Liao Y, Chen Z, Zhao S, Ran Q, Han C, Hoa PTT
Journal of gastrointestinal oncology 2022 Jun;13(3):1423-1432
Journal of gastrointestinal oncology 2022 Jun;13(3):1423-1432
The anti-fatigue activity of corn peptides and their effect on gut bacteria.
Feng Z, Wei Y, Xu Y, Zhang R, Li M, Qin H, Gu R, Cai M
Journal of the science of food and agriculture 2022 Jun;102(8):3456-3466
Journal of the science of food and agriculture 2022 Jun;102(8):3456-3466
Psoralen alleviates radiation-induced bone injury by rescuing skeletal stem cell stemness through AKT-mediated upregulation of GSK-3β and NRF2.
Yin BF, Li ZL, Yan ZQ, Guo Z, Liang JW, Wang Q, Zhao ZD, Li PL, Hao RC, Han MY, Li XT, Mao N, Ding L, Chen DF, Gao Y, Zhu H
Stem cell research & therapy 2022 Jun 7;13(1):241
Stem cell research & therapy 2022 Jun 7;13(1):241
Hexokinase 2-mediated glycolysis promotes receptor activator of NF-κB ligand expression in Porphyromonas gingivalis lipopolysaccharide-treated osteoblasts.
Yu Y, Jiang L, Li J, Lei L, Li H
Journal of periodontology 2022 Jul;93(7):1036-1047
Journal of periodontology 2022 Jul;93(7):1036-1047
KGF-2 Regulates STAP-2-Mediated Signal Transducer and Activator of Transcription 3 Signaling and Reduces Skin Scar Formation.
Zhou Q, Gong J, Bi J, Yang X, Zhang L, Lu C, Li L, Chen M, Cai J, Yang R, Li X, Li Z, Wang X
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
The Journal of investigative dermatology 2022 Jul;142(7):2003-2013.e5
Extracellular Vesicles from BMSCs Prevent Glucocorticoid-Induced BMECs Injury by Regulating Autophagy via the PI3K/Akt/mTOR Pathway.
Ma J, Shen M, Yue D, Wang W, Gao F, Wang B
Cells 2022 Jul 3;11(13)
Cells 2022 Jul 3;11(13)
Inhibition of CSPG receptor PTPσ promotes migration of newly born neuroblasts, axonal sprouting, and recovery from stroke.
Luo F, Wang J, Zhang Z, You Z, Bedolla A, Okwubido-Williams F, Huang LF, Silver J, Luo Y
Cell reports 2022 Jul 26;40(4):111137
Cell reports 2022 Jul 26;40(4):111137
N-glycosylation of GDF15 abolishes its inhibitory effect on EGFR in AR inhibitor-resistant prostate cancer cells.
Wang R, Wen P, Yang G, Feng Y, Mi Y, Wang X, Zhu S, Chen YQ
Cell death & disease 2022 Jul 19;13(7):626
Cell death & disease 2022 Jul 19;13(7):626
Glycyrrhizic Acid Attenuates Pulmonary Fibrosis of Silicosis by Inhibiting the Interaction between HMGB1 and BRG1 through PI3K/Akt/mTOR Pathway.
Niu Z, Lin J, Hao C, Xu X, Wang C, Dai K, Deng X, Deng M, Guo Y, Yao W
International journal of environmental research and public health 2022 Jul 18;19(14)
International journal of environmental research and public health 2022 Jul 18;19(14)
ANGPTL8 is a negative regulator in pathological cardiac hypertrophy.
Hu L, Wei J, Zhang Y, Wang Z, Tang J, Tang J, Gao Y, Zhang X, Li Y, Liu Y, Ma S, Guo X, Zhang Q
Cell death & disease 2022 Jul 18;13(7):621
Cell death & disease 2022 Jul 18;13(7):621
Rab22a promotes the proliferation, migration, and invasion of lung adenocarcinoma via up-regulating PI3K/Akt/mTOR signaling pathway.
Wang J, Luo X, Lu J, Wang X, Miao Y, Li Q, Wang L
Experimental cell research 2022 Jul 15;416(2):113179
Experimental cell research 2022 Jul 15;416(2):113179
Jiedu Tongluo Baoshen formula enhances podocyte autophagy and reduces proteinuria in diabetic kidney disease by inhibiting PI3K/Akt/mTOR signaling pathway.
Jin D, Liu F, Yu M, Zhao Y, Yan G, Xue J, Sun Y, Zhao D, Li X, Qi W, Wang X
Journal of ethnopharmacology 2022 Jul 15;293:115246
Journal of ethnopharmacology 2022 Jul 15;293:115246
Chronic vitamin D(3) supplementation alleviates cognition impairment via inhibition of oxidative stress regulated by PI3K/AKT/Nrf2 in APP/PS1 transgenic mice.
Lin J, Niu Z, Xue Y, Gao J, Zhang M, Li M, Peng Y, Zhang S, Li W, Zhang Q, Li X
Neuroscience letters 2022 Jul 13;783:136725
Neuroscience letters 2022 Jul 13;783:136725
Protective effects of Huang-Lian-Jie-Du Decoction on diabetic nephropathy through regulating AGEs/RAGE/Akt/Nrf2 pathway and metabolic profiling in db/db mice.
Tang D, He WJ, Zhang ZT, Shi JJ, Wang X, Gu WT, Chen ZQ, Xu YH, Chen YB, Wang SM
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777
Phytomedicine : international journal of phytotherapy and phytopharmacology 2022 Jan;95:153777
TNFSF9 promotes metastasis of pancreatic cancer by regulating M2 polarization of macrophages through Src/FAK/p-Akt/IL-1β signaling.
Wu J, Wang Y, Yang Y, Liu F, Jiang Z, Jiang Z
International immunopharmacology 2022 Jan;102:108429
International immunopharmacology 2022 Jan;102:108429
METTL3-Mediated m(6)A Modification of lncRNA MALAT1 Facilitates Prostate Cancer Growth by Activation of PI3K/AKT Signaling.
Mao Y, Li W, Weng Y, Hua B, Gu X, Lu C, Xu B, Xu H, Wang Z
Cell transplantation 2022 Jan-Dec;31:9636897221122997
Cell transplantation 2022 Jan-Dec;31:9636897221122997
PGK1 represses autophagy-mediated cell death to promote the proliferation of liver cancer cells by phosphorylating PRAS40.
Zhang T, Wang Y, Yu H, Zhang T, Guo L, Xu J, Wei X, Wang N, Wu Y, Wang X, Huang L
Cell death & disease 2022 Jan 20;13(1):68
Cell death & disease 2022 Jan 20;13(1):68
AKT1/HK2 Axis-mediated Glucose Metabolism: A Novel Therapeutic Target of Sulforaphane in Bladder Cancer.
Huang L, He C, Zheng S, Wu C, Ren M, Shan Y
Molecular nutrition & food research 2022 Feb;66(3):e2100738
Molecular nutrition & food research 2022 Feb;66(3):e2100738
CENPO regulated proliferation and apoptosis of colorectal cancer in a p53-dependent manner.
Liu Z, Chen C, Yan M, Zeng X, Zhang Y, Lai D
Discover oncology 2022 Feb 3;13(1):8
Discover oncology 2022 Feb 3;13(1):8
Mesenchyme homeobox 2 has a cancer-inhibiting function in breast carcinoma via affection of the PI3K/AKT/mTOR and ERK1/2 pathways.
Cai Y, Liu Y, Sun Y, Ren Y
Biochemical and biophysical research communications 2022 Feb 19;593:20-27
Biochemical and biophysical research communications 2022 Feb 19;593:20-27
Exploring the pharmacological mechanism of calculus bovis in cerebral ischaemic stroke using a network pharmacology approach.
Du X, Li C, Zhang S, Sun C, Zhang X, Chen C, Wang X, Cheng F, Wang Q
Journal of ethnopharmacology 2022 Feb 10;284:114507
Journal of ethnopharmacology 2022 Feb 10;284:114507
The neuroprotective effects of phosphocreatine on amyloid beta 25-35-induced differentiated neuronal cell death through inhibition of AKT/GSK-3β /Tau/APP/CDK5 pathways in vivo and vitro.
Ai J, Wang H, Chu P, Shopit A, Niu M, Ahmad N, Tesfaldet T, Wang FH, Fang JN, Li X, Tang SJ, Han QJ, Han G, Peng J, Tang Z
Free radical biology & medicine 2022 Feb 1;179:416-417
Free radical biology & medicine 2022 Feb 1;179:416-417
LRPPRC inhibits autophagy and promotes foam cell formation in atherosclerosis.
Xu Z, Li X, Ding Z, Zhang Y, Peng Z, Yang X, Cao W, Du R
The FEBS journal 2022 Dec;289(23):7545-7560
The FEBS journal 2022 Dec;289(23):7545-7560
A Novel Mast Cell Stabilizer JM25-1 Rehabilitates Impaired Gut Barrier by Targeting the Corticotropin-Releasing Hormone Receptors.
Sun Y, Li H, Liu L, Bai X, Wu L, Shan J, Sun X, Wang Q, Guo Y
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
Pharmaceuticals (Basel, Switzerland) 2022 Dec 29;16(1)
YAP1-TEAD1 mediates the perineural invasion of prostate cancer cells induced by cancer-associated fibroblasts.
Shen T, Li Y, Wang D, Su Y, Li G, Shang Z, Niu Y, Tan X
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166540
Biochimica et biophysica acta. Molecular basis of disease 2022 Dec 1;1868(12):166540
l-Arginine prevents 4-hydroxy-2-nonenal accumulation and depresses inflammation via inhibiting NF-κB activation.
Liang M, Wang Z, Li H, Liu B, Yang L
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23087
Journal of biochemical and molecular toxicology 2022 Aug;36(8):e23087
PP2Acα regulates epidermal cell proliferation via the EGFR/AKT/mTOR pathway in psoriasis-like skin lesions caused by PPP2CA deficiency.
Tao T, Chen Y, Chen J, Lian C, Xu S, Zhang M, Fang C
Experimental dermatology 2022 Aug;31(8):1154-1164
Experimental dermatology 2022 Aug;31(8):1154-1164
Long noncoding RNA BMPR1B-AS1 facilitates endometrial cancer cell proliferation and metastasis by sponging miR-7-2-3p to modulate the DCLK1/Akt/NF-κB pathway.
Lai T, Qiu H, Si L, Zhen Y, Chu D, Guo R
Cell cycle (Georgetown, Tex.) 2022 Aug;21(15):1599-1618
Cell cycle (Georgetown, Tex.) 2022 Aug;21(15):1599-1618
The miR-410-5p /ITGA6 axis participates in the pathogenesis of recurrent abortion by regulating the biological function of trophoblast.
Wu S, Liu H, Zhou M, Shang Y, Luo L, Chen J, Yang J
Journal of reproductive immunology 2022 Aug;152:103647
Journal of reproductive immunology 2022 Aug;152:103647
Dapagliflozin Improves Cardiac Function, Remodeling, Myocardial Apoptosis, and Inflammatory Cytokines in Mice with Myocardial Infarction.
Wang K, Li Z, Sun Y, Liu X, Ma W, Ding Y, Hong J, Qian L, Xu D
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
Journal of cardiovascular translational research 2022 Aug;15(4):786-796
The inhibitory effect and mechanism of Yi-qi-hua-yu-jie-du decoction on the drug resistance of gastric cancer stem cells based on ABC transporters.
Huang W, Wen F, Gu P, Liu J, Xia Y, Li Y, Zhou J, Song S, Ruan S, Gu S, Chen X, Shu P
Chinese medicine 2022 Aug 9;17(1):93
Chinese medicine 2022 Aug 9;17(1):93
Progesterone activates GPR126 to promote breast cancer development via the Gi pathway.
An W, Lin H, Ma L, Zhang C, Zheng Y, Cheng Q, Ma C, Wu X, Zhang Z, Zhong Y, Wang M, He D, Yang Z, Du L, Feng S, Wang C, Yang F, Xiao P, Zhang P, Yu X, Sun JP
Proceedings of the National Academy of Sciences of the United States of America 2022 Apr 12;119(15):e2117004119
Proceedings of the National Academy of Sciences of the United States of America 2022 Apr 12;119(15):e2117004119
Nrf2 Activation Is Involved in Cyclic Mechanical Stress-Stimulated Osteogenic Differentiation in Periodontal Ligament Stem Cells via PI3K/Akt Signaling and HO1-SOD2 Interaction.
Xi X, Li Z, Liu H, Chen S, Liu D
Frontiers in cell and developmental biology 2021;9:816000
Frontiers in cell and developmental biology 2021;9:816000
Overexpression of PTPRN Promotes Metastasis of Lung Adenocarcinoma and Suppresses NK Cell Cytotoxicity.
Song X, Jiao X, Yan H, Yu L, Jiang L, Zhang M, Chen L, Ju M, Wang L, Wei Q, Zhao L, Wei M
Frontiers in cell and developmental biology 2021;9:622018
Frontiers in cell and developmental biology 2021;9:622018
CYP2C8 Suppress Proliferation, Migration, Invasion and Sorafenib Resistance of Hepatocellular Carcinoma via PI3K/Akt/p27(kip1) Axis.
Zhou X, Li TM, Luo JZ, Lan CL, Wei ZL, Fu TH, Liao XW, Zhu GZ, Ye XP, Peng T
Journal of hepatocellular carcinoma 2021;8:1323-1338
Journal of hepatocellular carcinoma 2021;8:1323-1338
Fisetin inhibits inflammation and induces autophagy by mediating PI3K/AKT/mTOR signaling in LPS-induced RAW264.7 cells.
Sun Y, Qin H, Zhang H, Feng X, Yang L, Hou DX, Chen J
Food & nutrition research 2021;65
Food & nutrition research 2021;65
The mechanism and candidate compounds of aged citrus peel (chenpi) preventing chronic obstructive pulmonary disease and its progression to lung cancer.
Zhou L, Gu W, Kui F, Gao F, Niu Y, Li W, Zhang Y, Guo L, Wang J, Guo Z, Du G
Food & nutrition research 2021;65
Food & nutrition research 2021;65
Expression of Ubiquitin-specific protease 7 in oral squamous cell carcinoma promotes tumor cell proliferation and invasion.
Yang X, Jin J, Yang J, Zhou L, Mi S, Qi G
Genetics and molecular biology 2021;44(4):e20210058
Genetics and molecular biology 2021;44(4):e20210058
Tuftelin 1 (TUFT1) Promotes the Proliferation and Migration of Renal Cell Carcinoma via PI3K/AKT Signaling Pathway.
Lin H, Zeng W, Lei Y, Chen D, Nie Z
Pathology oncology research : POR 2021;27:640936
Pathology oncology research : POR 2021;27:640936
Lipidomic Alterations and PPARα Activation Induced by Resveratrol Lead to Reduction in Lesion Size in Endometriosis Models.
Chen Z, Wang C, Lin C, Zhang L, Zheng H, Zhou Y, Li X, Li C, Zhang X, Yang X, Guan M, Xi Y
Oxidative medicine and cellular longevity 2021;2021:9979953
Oxidative medicine and cellular longevity 2021;2021:9979953
Ganoderma lucidum Spore Polysaccharide Inhibits the Growth of Hepatocellular Carcinoma Cells by Altering Macrophage Polarity and Induction of Apoptosis.
Song M, Li ZH, Gu HS, Tang RY, Zhang R, Zhu YL, Liu JL, Zhang JJ, Wang LY
Journal of immunology research 2021;2021:6696606
Journal of immunology research 2021;2021:6696606
OM-MSCs Alleviate the Golgi Apparatus Stress Response following Cerebral Ischemia/Reperfusion Injury via the PEDF-PI3K/Akt/mTOR Signaling Pathway.
He J, Liu J, Huang Y, Tang X, Xiao H, Liu Z, Jiang Z, Zeng L, Hu Z, Lu M
Oxidative medicine and cellular longevity 2021;2021:4805040
Oxidative medicine and cellular longevity 2021;2021:4805040
Hypoxia Enhances Activity and Malignant Behaviors of Colorectal Cancer Cells through the STAT3/MicroRNA-19a/PTEN/PI3K/AKT Axis.
Tang Y, Weng X, Liu C, Li X, Chen C
Analytical cellular pathology (Amsterdam) 2021;2021:4132488
Analytical cellular pathology (Amsterdam) 2021;2021:4132488
Cox-2 Antagonizes the Protective Effect of Sevoflurane on Hypoxia/Reoxygenation-Induced Cardiomyocyte Apoptosis through Inhibiting the Akt Pathway.
Guo C, Zhang L, Gao Y, Sun J, Fan L, Bai Y, Zhang J, Naren G, Yang J, Li L
Disease markers 2021;2021:4114593
Disease markers 2021;2021:4114593
The Roles of Liver Inflammation and the Insulin Signaling Pathway in PM2.5 Instillation-Induced Insulin Resistance in Wistar Rats.
Zhang Z, Hu S, Fan P, Li L, Feng S, Xiao H, Zhu L
Disease markers 2021;2021:2821673
Disease markers 2021;2021:2821673
The COL11A1/Akt/CREB signaling axis enables mitochondrial-mediated apoptotic evasion to promote chemoresistance in pancreatic cancer cells through modulating BAX/BCL-2 function.
Wang H, Ren R, Yang Z, Cai J, Du S, Shen X
Journal of Cancer 2021;12(5):1406-1420
Journal of Cancer 2021;12(5):1406-1420
B7-H3 inhibits apoptosis of gastric cancer cell by interacting with Fibronectin.
Sun M, Xie J, Zhang D, Chen C, Lin S, Chen Y, Zhang G
Journal of Cancer 2021;12(24):7518-7526
Journal of Cancer 2021;12(24):7518-7526
Sempervirine Mediates Autophagy and Apoptosis via the Akt/mTOR Signaling Pathways in Glioma Cells.
Li G, Zhong Y, Wang W, Jia X, Zhu H, Jiang W, Song Y, Xu W, Wu S
Frontiers in pharmacology 2021;12:770667
Frontiers in pharmacology 2021;12:770667
Selective STAT3 Inhibitor Alantolactone Ameliorates Osteoarthritis via Regulating Chondrocyte Autophagy and Cartilage Homeostasis.
Pei W, Huang X, Ni B, Zhang R, Niu G, You H
Frontiers in pharmacology 2021;12:730312
Frontiers in pharmacology 2021;12:730312
Autophagic Inhibition of Caveolin-1 by Compound Phyllanthus urinaria L. Activates Ubiquitination and Proteasome Degradation of β-catenin to Suppress Metastasis of Hepatitis B-Associated Hepatocellular Carcinoma.
Huang D, Yang B, Yao Y, Liao M, Zhang Y, Zeng Y, Zhang F, Wang N, Tong G
Frontiers in pharmacology 2021;12:659325
Frontiers in pharmacology 2021;12:659325
Autophagy Blockade by Ai Du Qing Formula Promotes Chemosensitivity of Breast Cancer Stem Cells Via GRP78/β-Catenin/ABCG2 Axis.
Liao M, Wang C, Yang B, Huang D, Zheng Y, Wang S, Wang X, Zhang J, Tang C, Xu Z, He Y, Huang R, Zhang F, Wang Z, Wang N
Frontiers in pharmacology 2021;12:659297
Frontiers in pharmacology 2021;12:659297
Therapeutic Potential of CUDC-907 (Fimepinostat) for Hepatocarcinoma Treatment Revealed by Tumor Spheroids-Based Drug Screening.
Liao W, Yang W, Xu J, Yan Z, Pan M, Xu X, Zhou S, Zhu Y, Lan J, Zeng M, Han X, Li S, Li Y, Liang K, Gao Y, Peng Q
Frontiers in pharmacology 2021;12:658197
Frontiers in pharmacology 2021;12:658197
Lack of Mof reduces acute liver injury by enhancing transcriptional activation of Igf1.
Wang M, Liu H, Zhang X, Zhao W, Li D, Xu C, Wu Z, Xie F, Li X
Journal of cellular physiology 2021 Sep;236(9):6559-6570
Journal of cellular physiology 2021 Sep;236(9):6559-6570
PKC-β/Alox5 axis activation promotes Bcr-Abl-independent TKI-resistance in chronic myeloid leukemia.
Ma D, Liu P, Wang P, Zhou Z, Fang Q, Wang J
Journal of cellular physiology 2021 Sep;236(9):6312-6327
Journal of cellular physiology 2021 Sep;236(9):6312-6327
Targeting IFN-γ-inducible lysosomal thiol reductase overcomes chemoresistance in AML through regulating the ROS-mediated mitochondrial damage.
Niu LT, Wang YQ, Wong CCL, Gao SX, Mo XD, Huang XJ
Translational oncology 2021 Sep;14(9):101159
Translational oncology 2021 Sep;14(9):101159
Targeting cancer cell plasticity by HDAC inhibition to reverse EBV-induced dedifferentiation in nasopharyngeal carcinoma.
Xie J, Wang Z, Fan W, Liu Y, Liu F, Wan X, Liu M, Wang X, Zeng D, Wang Y, He B, Yan M, Zhang Z, Zhang M, Hou Z, Wang C, Kang Z, Fang W, Zhang L, Lam EW, Guo X, Yan J, Zeng Y, Chen M, Liu Q
Signal transduction and targeted therapy 2021 Sep 4;6(1):333
Signal transduction and targeted therapy 2021 Sep 4;6(1):333
Round Scad-Derived Octapeptide WCPFSRSF Confers Neuroprotection by Regulating Akt/Nrf2/NFκB Signaling.
Zhang Q, Su G, Yang Q, Wei Z, Wang J, Zheng L, Zhao M
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Journal of agricultural and food chemistry 2021 Sep 15;69(36):10606-10616
Quercitrin Rapidly Alleviated Depression-like Behaviors in Lipopolysaccharide-Treated Mice: The Involvement of PI3K/AKT/NF-κB Signaling Suppression and CREB/BDNF Signaling Restoration in the Hippocampus.
Sun Y, Zhang H, Wu Z, Yu X, Yin Y, Qian S, Wang Z, Huang J, Wang W, Liu T, Xue W, Chen G
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
ACS chemical neuroscience 2021 Sep 15;12(18):3387-3396
Sodium alginate/collagen/stromal cell-derived factor-1 neural scaffold loaded with BMSCs promotes neurological function recovery after traumatic brain injury.
Ma S, Zhou J, Huang T, Zhang Z, Xing Q, Zhou X, Zhang K, Yao M, Cheng T, Wang X, Wen X, Guan F
Acta biomaterialia 2021 Sep 1;131:185-197
Acta biomaterialia 2021 Sep 1;131:185-197
Mice lacking the proton channel Hv1 exhibit sex-specific differences in glucose homeostasis.
Pang H, Li J, Wang Y, Su X, Gao Y, Li SJ
The Journal of biological chemistry 2021 Oct;297(4):101212
The Journal of biological chemistry 2021 Oct;297(4):101212
Erianin, the main active ingredient of Dendrobium chrysotoxum Lindl, inhibits precancerous lesions of gastric cancer (PLGC) through suppression of the HRAS-PI3K-AKT signaling pathway as revealed by network pharmacology and in vitro experimental verification.
Wang Y, Chu F, Lin J, Li Y, Johnson N, Zhang J, Gai C, Su Z, Cheng H, Wang L, Ding X
Journal of ethnopharmacology 2021 Oct 28;279:114399
Journal of ethnopharmacology 2021 Oct 28;279:114399
FGGY carbohydrate kinase domain containing is expressed and alternatively spliced in skeletal muscle and attenuates MAP kinase and Akt signaling.
Smith AL, Gjoka E, Izhar M, Novo KJ, Mason BC, De Las Casas A, Waddell DS
Gene 2021 Oct 20;800:145836
Gene 2021 Oct 20;800:145836
Elaiophylin reduces body weight and lowers glucose levels in obese mice by activating AMPK.
Bao R, Meng Y, Zhang H, Yang C, Li W, Zhang C, Zhang J, Sun R, Li Z, Jiang W, Zhang C, Zhang C, Yuan HX, Dang Y
Cell death & disease 2021 Oct 20;12(11):972
Cell death & disease 2021 Oct 20;12(11):972
Knockdown of ST6Gal-I expression in human hepatocellular carcinoma cells inhibits their exosome-mediated proliferation- and migration-promoting effects.
Wang L, Chen X, Wang L, Wang S, Li W, Liu Y, Zhang J
IUBMB life 2021 Nov;73(11):1378-1391
IUBMB life 2021 Nov;73(11):1378-1391
Nitrate increases cisplatin chemosensitivity of oral squamous cell carcinoma via REDD1/AKT signaling pathway.
Feng Y, Cao X, Zhao B, Song C, Pang B, Hu L, Zhang C, Wang J, He J, Wang S
Science China. Life sciences 2021 Nov;64(11):1814-1828
Science China. Life sciences 2021 Nov;64(11):1814-1828
SC66 inhibits the proliferation and induces apoptosis of human bladder cancer cells by targeting the AKT/β-catenin pathway.
Chen W, Zhao S, Yu W, Rao T, Ruan Y, Zhu S, Xia Y, Song H, Cheng F
Journal of cellular and molecular medicine 2021 Nov;25(22):10684-10697
Journal of cellular and molecular medicine 2021 Nov;25(22):10684-10697
A network pharmacology approach to reveal the pharmacological targets and biological mechanism of compound kushen injection for treating pancreatic cancer based on WGCNA and in vitro experiment validation.
Wu C, Huang ZH, Meng ZQ, Fan XT, Lu S, Tan YY, You LM, Huang JQ, Stalin A, Ye PZ, Wu ZS, Zhang JY, Liu XK, Zhou W, Zhang XM, Wu JR
Chinese medicine 2021 Nov 22;16(1):121
Chinese medicine 2021 Nov 22;16(1):121
Yi-Qi-Jian-Pi formula modulates the PI3K/AKT signaling pathway to attenuate acute-on-chronic liver failure by suppressing hypoxic injury and apoptosis in vivo and in vitro.
Tang L, Wang F, Xiao L, Shen M, Xia S, Zhang Z, Zhang F, Zheng S, Tan S
Journal of ethnopharmacology 2021 Nov 15;280:114411
Journal of ethnopharmacology 2021 Nov 15;280:114411
Dihydromyricetin ameliorates vascular calcification in chronic kidney disease by targeting AKT signaling.
Feng L, Que D, Li Z, Zhong X, Yan J, Wei J, Zhang X, Yang P, Ou C, Chen M
Clinical science (London, England : 1979) 2021 Nov 12;135(21):2483-2502
Clinical science (London, England : 1979) 2021 Nov 12;135(21):2483-2502
The Effects of Flavonoid Apigenin on Male Reproductive Health: Inhibition of Spermatogonial Proliferation through Downregulation of Prmt7/Akt3 Pathway.
Wang B, Zhang M, Guo J, Liu Z, Zhou R, Guo F, Li K, Mu Y
International journal of molecular sciences 2021 Nov 11;22(22)
International journal of molecular sciences 2021 Nov 11;22(22)
Hepatic COX-2 expression protects mice from an alcohol-high fat diet-induced metabolic disorder by involving protein acetylation related energy metabolism.
Chen M, Sun X, Wei W, Cucarella C, Martín-Sanz P, Casado M, Pi L, Ren B, Cao Q
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Alcohol (Fayetteville, N.Y.) 2021 May;92:41-52
Activation of Wnt/β-catenin signaling restores insulin sensitivity in insulin resistant neurons through transcriptional regulation of IRS-1.
Tian S, Tan S, Jia W, Zhao J, Sun X
Journal of neurochemistry 2021 May;157(3):467-478
Journal of neurochemistry 2021 May;157(3):467-478
Qingjie Fuzheng Granule suppresses lymphangiogenesis in colorectal cancer via the VEGF-C/VEGFR-3 dependent PI3K/AKT pathway.
Huang B, Lu Y, Gui M, Guan J, Lin M, Zhao J, Mao Q, Lin J
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111331
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2021 May;137:111331
MicroRNA-216a targets WT1 expression and regulates KRT7 transcription to mediate the progression of pancreatic cancer-A transcriptome analysis.
Wang W, Wang J, Yang C, Wang J
IUBMB life 2021 Jun;73(6):866-882
IUBMB life 2021 Jun;73(6):866-882
Design, synthesis and biological evaluation of anilide (dicarboxylic acid) shikonin esters as antitumor agents through targeting PI3K/Akt/mTOR signaling pathway.
Ma Y, Yang X, Han H, Wen Z, Yang M, Zhang Y, Fu J, Wang X, Yin T, Lu G, Qi J, Lin H, Wang X, Yang Y
Bioorganic chemistry 2021 Jun;111:104872
Bioorganic chemistry 2021 Jun;111:104872
NOL4L, a novel nuclear protein, promotes cell proliferation and metastasis by enhancing the PI3K/AKT pathway in ovarian cancer.
Lin F, Zhou J, Li X, Wang X
Biochemical and biophysical research communications 2021 Jun 25;559:121-128
Biochemical and biophysical research communications 2021 Jun 25;559:121-128
Treatment of keloids through Runx2 siRNA‑induced inhibition of the PI3K/AKT signaling pathway.
Lv W, Wu M, Ren Y, Luo X, Hu W, Zhang Q, Wu Y
Molecular medicine reports 2021 Jan;23(1)
Molecular medicine reports 2021 Jan;23(1)
Hypoxic pancreatic stellate cell-derived exosomal mirnas promote proliferation and invasion of pancreatic cancer through the PTEN/AKT pathway.
Cao W, Zeng Z, He Z, Lei S
Aging 2021 Feb 26;13(5):7120-7132
Aging 2021 Feb 26;13(5):7120-7132
Functions of Forkhead Box O on Glucose Metabolism in Abalone Haliotis discus hannai and Its Responses to High Levels of Dietary Lipid.
Wang L, Guo Y, Pan M, Li X, Huang D, Liu Y, Wu C, Zhang W, Mai K
Genes 2021 Feb 20;12(2)
Genes 2021 Feb 20;12(2)
BAIAP2L2 promotes the proliferation, migration and invasion of osteosarcoma associated with the Wnt/β-catenin pathway.
Guo H, Peng J, Hu J, Chang S, Liu H, Luo H, Chen X, Tang H, Chen Y
Journal of bone oncology 2021 Dec;31:100393
Journal of bone oncology 2021 Dec;31:100393
The protective effect of Metformin/Donepezil in diabetic mice brain: evidence from bioinformatics analysis and experiments.
Hou Y, Li FZ
European review for medical and pharmacological sciences 2021 Dec;25(24):7668-7678
European review for medical and pharmacological sciences 2021 Dec;25(24):7668-7678
Protective effects of safranal on hypoxia/reoxygenation-induced injury in H9c2 cardiac myoblasts via the PI3K/AKT/GSK3β signaling pathway.
Wang H, Zheng B, Che K, Han X, Li L, Wang H, Liu Y, Shi J, Sun S
Experimental and therapeutic medicine 2021 Dec;22(6):1400
Experimental and therapeutic medicine 2021 Dec;22(6):1400
Protective Effect of Flavonoids from a Deep-Sea-Derived Arthrinium sp. against ox-LDL-Induced Oxidative Injury through Activating the AKT/Nrf2/HO-1 Pathway in Vascular Endothelial Cells.
Hou JR, Wang YH, Zhong YN, Che TT, Hu Y, Bao J, Meng N
Marine drugs 2021 Dec 18;19(12)
Marine drugs 2021 Dec 18;19(12)
Nr2e1 deficiency aggravates insulin resistance and chronic inflammation of visceral adipose tissues in a diet-induced obese mice model.
He G, Gu J, Wang H, Cheng S, Xiong Q, Ke M, Hu Y, Feng J, Song L, Liu Z, Xu Y
Life sciences 2021 Aug 1;278:119562
Life sciences 2021 Aug 1;278:119562
Melatonin prevents diabetes-associated cognitive dysfunction from microglia-mediated neuroinflammation by activating autophagy via TLR4/Akt/mTOR pathway.
Cui Y, Yang M, Wang Y, Ren J, Lin P, Cui C, Song J, He Q, Hu H, Wang K, Sun Y
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21485
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Apr;35(4):e21485
TBHQ Attenuates Neurotoxicity Induced by Methamphetamine in the VTA through the Nrf2/HO-1 and PI3K/AKT Signaling Pathways.
Meng X, Zhang C, Guo Y, Han Y, Wang C, Chu H, Kong L, Ma H
Oxidative medicine and cellular longevity 2020;2020:8787156
Oxidative medicine and cellular longevity 2020;2020:8787156
AOC1 Contributes to Tumor Progression by Promoting the AKT and EMT Pathways in Gastric Cancer.
Xu F, Xu Y, Xiong JH, Zhang JH, Wu J, Luo J, Xiong JP
Cancer management and research 2020;12:1789-1798
Cancer management and research 2020;12:1789-1798
Circadian Clock Protein PERIOD2 Suppresses the PI3K/Akt Pathway and Promotes Cisplatin Sensitivity in Ovarian Cancer.
Wang Z, Li F, Wei M, Zhang S, Wang T
Cancer management and research 2020;12:11897-11908
Cancer management and research 2020;12:11897-11908
Susceptibility to Hyperglycemia in Rats With Stress-Induced Depressive-Like Behavior: Involvement of IL-6 Mediated Glucose Homeostasis Signaling.
Li X, Qiu W, Li N, Da X, Ma Q, Hou Y, Wang T, Song M, Chen J
Frontiers in psychiatry 2020;11:557
Frontiers in psychiatry 2020;11:557
LMP1 promotes nasopharyngeal carcinoma metastasis through NTRK2-mediated anoikis resistance.
Li Z, Zhou Z, Wu X, Zhou Q, Liao C, Liu Y, Li D, Shen L, Feng D, Yang L
American journal of cancer research 2020;10(7):2083-2099
American journal of cancer research 2020;10(7):2083-2099
PRDX2 plays an oncogenic role in esophageal squamous cell carcinoma via Wnt/β-catenin and AKT pathways.
Feng AL, Han X, Meng X, Chen Z, Li Q, Shu W, Dai H, Zhu J, Yang Z
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Clinical & translational oncology : official publication of the Federation of Spanish Oncology Societies and of the National Cancer Institute of Mexico 2020 Oct;22(10):1838-1848
Ambient PM2.5 caused cardiac dysfunction through FoxO1-targeted cardiac hypertrophy and macrophage-activated fibrosis in mice.
Su X, Tian J, Li B, Zhou L, Kang H, Pei Z, Zhang M, Li C, Wu M, Wang Q, Han B, Chu C, Pang Y, Ning J, Zhang B, Niu Y, Zhang R
Chemosphere 2020 May;247:125881
Chemosphere 2020 May;247:125881
Inhibition of protein phosphatase methylesterase 1 dysregulates MAP kinase signaling and attenuates muscle cell differentiation.
Labuzan SA, Lynch SA, Cooper LM, Waddell DS
Gene 2020 May 20;739:144515
Gene 2020 May 20;739:144515
High PD‑L1 expression drives glycolysis via an Akt/mTOR/HIF‑1α axis in acute myeloid leukemia.
Ma P, Xing M, Han L, Gan S, Ma J, Wu F, Huang Y, Chen Y, Tian W, An C, Sun H, Sun L
Oncology reports 2020 Mar;43(3):999-1009
Oncology reports 2020 Mar;43(3):999-1009
Cyclovirobuxine D Exerts Anticancer Effects by Suppressing the EGFR-FAK-AKT/ERK1/2-Slug Signaling Pathway in Human Hepatocellular Carcinoma.
Zhang J, Chen Y, Lin J, Jia R, An T, Dong T, Zhang Y, Yang X
DNA and cell biology 2020 Mar;39(3):355-367
DNA and cell biology 2020 Mar;39(3):355-367
Fam83d modulates MAP kinase and AKT signaling and is induced during neurogenic skeletal muscle atrophy.
Cooper LM, Hanson A, Kavanagh JA, Waddell DS
Cellular signalling 2020 Jun;70:109576
Cellular signalling 2020 Jun;70:109576
PTPN3 Inhibits the Growth and Metastasis of Clear Cell Renal Cell Carcinoma via Inhibition of PI3K/AKT Signaling.
Peng XS, Yang JP, Qiang YY, Sun R, Cao Y, Zheng LS, Peng LX, Lang YH, Mei Y, Li CZ, Meng DF, Liu ZJ, Wang MD, Zhou FJ, Huang BJ, Qian CN
Molecular cancer research : MCR 2020 Jun;18(6):903-912
Molecular cancer research : MCR 2020 Jun;18(6):903-912
Long noncoding RNA linc00467 plays an oncogenic role in hepatocellular carcinoma by regulating the miR-18a-5p/NEDD9 axis.
Zheng Y, Nie P, Xu S
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Journal of cellular biochemistry 2020 Jun;121(5-6):3135-3144
Resveratrol inhibits the malignant progression of hepatocellular carcinoma via MARCH1-induced regulation of PTEN/AKT signaling.
Dai H, Li M, Yang W, Sun X, Wang P, Wang X, Su J, Wang X, Hu X, Zhao M
Aging 2020 Jun 12;12(12):11717-11731
Aging 2020 Jun 12;12(12):11717-11731
Effective-component compatibility of Bufei Yishen formula II inhibits mucus hypersecretion of chronic obstructive pulmonary disease rats by regulating EGFR/PI3K/mTOR signaling.
Li J, Ma J, Tian Y, Zhao P, Liu X, Dong H, Zheng W, Feng S, Zhang L, Wu M, Zhu L, Liu S, Zhao D
Journal of ethnopharmacology 2020 Jul 15;257:112796
Journal of ethnopharmacology 2020 Jul 15;257:112796
The anti-migration and anti-invasion effects of Bruceine D in human triple-negative breast cancer MDA-MB-231 cells.
Luo C, Wang Y, Wei C, Chen Y, Ji Z
Experimental and therapeutic medicine 2020 Jan;19(1):273-279
Experimental and therapeutic medicine 2020 Jan;19(1):273-279
An insertion mutation of ERBB2 enhances breast cancer cell growth and confers resistance to lapatinib through AKT signaling pathway.
Yang ZY, Yang L, Xu CW, Wang XJ, Lei L
Biology open 2020 Jan 24;9(1)
Biology open 2020 Jan 24;9(1)
Prucalopride inhibits lung cancer cell proliferation, invasion, and migration through blocking of the PI3K/AKT/mTor signaling pathway.
Chen M, Zhu LL, Su JL, Li GL, Wang J, Zhang YN
Human & experimental toxicology 2020 Feb;39(2):173-181
Human & experimental toxicology 2020 Feb;39(2):173-181
Epigenetic silencing of IGFBPL1 promotes esophageal cancer growth by activating PI3K-AKT signaling.
Liu Y, Zhang M, He T, Yang W, Wang L, Zhang L, Guo M
Clinical epigenetics 2020 Feb 10;12(1):22
Clinical epigenetics 2020 Feb 10;12(1):22
Human cathelicidin antimicrobial peptide suppresses proliferation, migration and invasion of oral carcinoma HSC-3 cells via a novel mechanism involving caspase-3 mediated apoptosis.
Chen X, Ji S, Si J, Zhang X, Wang X, Guo Y, Zou X
Molecular medicine reports 2020 Dec;22(6):5243-5250
Molecular medicine reports 2020 Dec;22(6):5243-5250
BML-111 inhibits EMT, migration and metastasis of TAMs-stimulated triple-negative breast cancer cells via ILK pathway.
Lin L, Luo X, Wang L, Xu F, He Y, Wang Q, Yuan C, Xu J, Yan L, Hao H
International immunopharmacology 2020 Aug;85:106625
International immunopharmacology 2020 Aug;85:106625
Phenolic Glycosides from the Roots of Ficus hirta Vahl. and Their Antineuroinflammatory Activities.
Ye X, Tian W, Wang G, Zhang X, Zhou M, Zeng D, Liu X, Yao X, Zhang Y, Chen H
Journal of agricultural and food chemistry 2020 Apr 8;68(14):4196-4204
Journal of agricultural and food chemistry 2020 Apr 8;68(14):4196-4204
Tetrandrine-Induced Autophagy in MDA-MB-231 Triple-Negative Breast Cancer Cell through the Inhibition of PI3K/AKT/mTOR Signaling.
Guo Y, Pei X
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
Evidence-based complementary and alternative medicine : eCAM 2019;2019:7517431
SSRP1 influences colorectal cancer cell growth and apoptosis via the AKT pathway.
Wang Q, Jia S, Jiao Y, Xu L, Wang D, Chen X, Hu X, Liang H, Wen N, Zhang S, Guo B, Zhang L
International journal of medical sciences 2019;16(12):1573-1582
International journal of medical sciences 2019;16(12):1573-1582
siPRDX2-elevated DNM3 inhibits the proliferation and metastasis of colon cancer cells via AKT signaling pathway.
Ma Y, Guan L, Han Y, Zhou Y, Li X, Liu Y, Zhang X, Zhang W, Li X, Wang S, Lu W
Cancer management and research 2019;11:5799-5811
Cancer management and research 2019;11:5799-5811
Autophagy Protects the Blood-Brain Barrier Through Regulating the Dynamic of Claudin-5 in Short-Term Starvation.
Yang Z, Huang C, Wu Y, Chen B, Zhang W, Zhang J
Frontiers in physiology 2019;10:2
Frontiers in physiology 2019;10:2
Knockdown of METTL14 inhibits the growth and invasion of cervical cancer.
Geng F, Fan MJ, Li J, Liang SM, Li CY, Li N
Translational cancer research 2019 Oct;8(6):2307-2315
Translational cancer research 2019 Oct;8(6):2307-2315
NKAP functions as an oncogene in Ewing sarcoma cells partly through the AKT signaling pathway.
Li F, Wu JT, Wang PF, Qu LZ
Experimental and therapeutic medicine 2019 Oct;18(4):3037-3045
Experimental and therapeutic medicine 2019 Oct;18(4):3037-3045
Combined targeting of PI3K and MEK effector pathways via CED for DIPG therapy.
Chang R, Tosi U, Voronina J, Adeuyan O, Wu LY, Schweitzer ME, Pisapia DJ, Becher OJ, Souweidane MM, Maachani UB
Neuro-oncology advances 2019 May-Dec;1(1):vdz004
Neuro-oncology advances 2019 May-Dec;1(1):vdz004
Nogo-B Receptor Directs Mitochondria-Associated Membranes to Regulate Vascular Smooth Muscle Cell Proliferation.
Yang YD, Li MM, Xu G, Feng L, Zhang EL, Chen J, Chen DW, Gao YQ
International journal of molecular sciences 2019 May 10;20(9)
International journal of molecular sciences 2019 May 10;20(9)
ITGA6 and RPSA synergistically promote pancreatic cancer invasion and metastasis via PI3K and MAPK signaling pathways.
Wu Y, Tan X, Liu P, Yang Y, Huang Y, Liu X, Meng X, Yu B, Wu M, Jin H
Experimental cell research 2019 Jun 1;379(1):30-47
Experimental cell research 2019 Jun 1;379(1):30-47
Allogeneic adipose-derived stem cells suppress mTORC1 pathway in a murine model of systemic lupus erythematosus.
Wei S, Xie S, Yang Z, Peng X, Gong L, Zhao K, Zeng K, Lai K
Lupus 2019 Feb;28(2):199-209
Lupus 2019 Feb;28(2):199-209
Dual-specificity tyrosine phosphorylation-regulated kinase 1A ameliorates insulin resistance in neurons by up-regulating IRS-1 expression.
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The Journal of biological chemistry 2019 Dec 27;294(52):20164-20176
The Journal of biological chemistry 2019 Dec 27;294(52):20164-20176
The Orexin-A-Regulated Akt/mTOR Pathway Promotes Cell Proliferation Through Inhibiting Apoptosis in Pancreatic Cancer Cells.
Suo L, Chang X, Zhao Y
Frontiers in endocrinology 2018;9:647
Frontiers in endocrinology 2018;9:647
Aspirin Reduces Cardiac Interstitial Fibrosis by Inhibiting Erk1/2-Serpine2 and P-Akt Signalling Pathways.
Li X, Wang G, QiLi M, Liang H, Li T, E X, Feng Y, Zhang Y, Liu X, Qian M, Xu B, Shen Z, Gitau SC, Zhao D, Shan H
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(5):1955-1965
Cellular physiology and biochemistry : international journal of experimental cellular physiology, biochemistry, and pharmacology 2018;45(5):1955-1965
UNBS5162 inhibits proliferation of human melanoma cells by inducing apoptosis via the PI3K/Akt pathway.
Shi X, Yang L, Xie J, Zhao Y, Cong J, Li Z, Li H, Cheng X, Fan J
Molecular medicine reports 2018 Sep;18(3):3382-3388
Molecular medicine reports 2018 Sep;18(3):3382-3388
miR-25 Promotes Melanoma Progression by regulating RNA binding motif protein 47.
Jiang QQ, Liu WB
Medecine sciences : M/S 2018 Oct;34 Focus issue F1:59-65
Medecine sciences : M/S 2018 Oct;34 Focus issue F1:59-65
Diosmetin Attenuates Akt Signaling Pathway by Modulating Nuclear Factor Kappa-Light-Chain-Enhancer of Activated B Cells (NF-κB)/Inducible Nitric Oxide Synthase (iNOS) in Streptozotocin (STZ)-Induced Diabetic Nephropathy Mice.
Jiang Y, Liu J, Zhou Z, Liu K, Liu C
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 2;24:7007-7014
Medical science monitor : international medical journal of experimental and clinical research 2018 Oct 2;24:7007-7014
Neuroprotective effect of phosphocreatine on oxidative stress and mitochondrial dysfunction induced apoptosis in vitro and in vivo: Involvement of dual PI3K/Akt and Nrf2/HO-1 pathways.
Li H, Tang Z, Chu P, Song Y, Yang Y, Sun B, Niu M, Qaed E, Shopit A, Han G, Ma X, Peng J, Hu M, Tang Z
Free radical biology & medicine 2018 May 20;120:228-238
Free radical biology & medicine 2018 May 20;120:228-238
Formononetin inhibits colon carcinoma cell growth and invasion by microRNA‑149‑mediated EphB3 downregulation and inhibition of PI3K/AKT and STAT3 signaling pathways.
Wang AL, Li Y, Zhao Q, Fan LQ
Molecular medicine reports 2018 Jun;17(6):7721-7729
Molecular medicine reports 2018 Jun;17(6):7721-7729
Salidroside mediates apoptosis and autophagy inhibition in concanavalin A-induced liver injury.
Feng J, Niu P, Chen K, Wu L, Liu T, Xu S, Li J, Li S, Wang W, Lu X, Yu Q, Liu N, Xu L, Wang F, Dai W, Xia Y, Fan X, Guo C
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Experimental and therapeutic medicine 2018 Jun;15(6):4599-4614
Chiral ruthenium(ii) complex as potent radiosensitizer of (125)I through DNA-damage-mediated apoptosis.
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RSC advances 2018 Jun 5;8(37):20612-20618
RSC advances 2018 Jun 5;8(37):20612-20618
Exosomes released by hepatocarcinoma cells endow adipocytes with tumor-promoting properties.
Wang S, Xu M, Li X, Su X, Xiao X, Keating A, Zhao RC
Journal of hematology & oncology 2018 Jun 14;11(1):82
Journal of hematology & oncology 2018 Jun 14;11(1):82
Qing brick tea (QBT) aqueous extract protects monosodium glutamate-induced obese mice against metabolic syndrome and involves up-regulation Transcription Factor Nuclear Factor-Erythroid 2-Related Factor 2 (Nrf2) antioxidant pathway.
Gao W, Xiao C, Hu J, Chen B, Wang C, Cui B, Deng P, Yang J, Deng Z
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:637-644
Biomedicine & pharmacotherapy = Biomedecine & pharmacotherapie 2018 Jul;103:637-644
Apigenin ameliorates vascular injury in rats with high fructose-induced metabolic disturbance by inhibiting PI3K/AKT/GLUT1.
Chen X, Tan J, Zhang L, Liu Y, Cheng Y, Zhang Q, Ding H
RSC advances 2018 Jul 2;8(43):24470-24476
RSC advances 2018 Jul 2;8(43):24470-24476
Apatinib promotes apoptosis of the SMMC-7721 hepatocellular carcinoma cell line via the PI3K/Akt pathway.
Zhang H, Cao Y, Chen Y, Li G, Yu H
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American journal of cancer research 2017;7(11):2220-2233
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Biochemical and biophysical research communications 2017 Mar 25;485(1):54-61
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Journal of molecular endocrinology 2017 Jan;58(1):15-23
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Cell death & disease 2017 Feb 2;8(2):e2591
DHPAC, a novel synthetic microtubule destabilizing agent, possess high anti-tumor activity in vincristine-resistant oral epidermoid carcinoma in vitro and in vivo.
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The international journal of biochemistry & cell biology 2017 Dec;93:1-11
The international journal of biochemistry & cell biology 2017 Dec;93:1-11
SOCS1 regulates hepatic regenerative response and provides prognostic makers for acute obstructive cholangitis.
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Scientific reports 2017 Aug 25;7(1):9482
Scientific reports 2017 Aug 25;7(1):9482
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Scientific reports 2017 Aug 24;7(1):9289
Enho Mutations Causing Low Adropin: A Possible Pathomechanism of MPO-ANCA Associated Lung Injury.
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EBioMedicine 2016 Jul;9:324-335
EBioMedicine 2016 Jul;9:324-335
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 60203-2-Ig(AKT antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunohistochemical of paraffin-embedded human cervical cancer using 60203-2-Ig(AKT antibody) at dilution of 1:50 (under 10x lens)
- Sample type
- tissue
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The AKT1 antibody from Proteintech is a mouse monoclonal antibody to a fusion protein of human AKT1. This antibody recognizes human,mouse, rat antigen. The AKT1 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
