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- References [12]
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- Product number
- H00253782-A01 - Provider product page
- Provider
- Novus Biologicals
- Proper citation
- Novus Cat#H00253782-A01, RRID:AB_2133108
- Product name
- Mouse Polyclonal LASS6 Antibody
- Antibody type
- Polyclonal
- Description
- Unpurified. LASS6 - LAG1 longevity assurance homolog 6 (S. cerevisiae)
- Reactivity
- Human, Mouse
- Host
- Mouse
- Isotype
- IgG
- Vial size
- 0.05 ml
- Storage
- Aliquot and store at -20C or -80C. Avoid freeze-thaw cycles.
Submitted references SIRT3 Deacetylates Ceramide Synthases: IMPLICATIONS FOR MITOCHONDRIAL DYSFUNCTION AND BRAIN INJURY.
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.
Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
Novgorodov SA, Riley CL, Keffler JA, Yu J, Kindy MS, Macklin WB, Lombard DB, Gudz TI
The Journal of biological chemistry 2016 Jan 22;291(4):1957-73
The Journal of biological chemistry 2016 Jan 22;291(4):1957-73
Cytochrome c oxidase deficiency accelerates mitochondrial apoptosis by activating ceramide synthase 6.
Schüll S, Günther SD, Brodesser S, Seeger JM, Tosetti B, Wiegmann K, Pongratz C, Diaz F, Witt A, Andree M, Brinkmann K, Krönke M, Wiesner RJ, Kashkar H
Cell death & disease 2015 Mar 12;6:e1691
Cell death & disease 2015 Mar 12;6:e1691
Radiation-induced acid ceramidase confers prostate cancer resistance and tumor relapse.
Cheng JC, Bai A, Beckham TH, Marrison ST, Yount CL, Young K, Lu P, Bartlett AM, Wu BX, Keane BJ, Armeson KE, Marshall DT, Keane TE, Smith MT, Jones EE, Drake RR Jr, Bielawska A, Norris JS, Liu X
The Journal of clinical investigation 2013 Oct;123(10):4344-58
The Journal of clinical investigation 2013 Oct;123(10):4344-58
Folate stress induces apoptosis via p53-dependent de novo ceramide synthesis and up-regulation of ceramide synthase 6.
Hoeferlin LA, Fekry B, Ogretmen B, Krupenko SA, Krupenko NI
The Journal of biological chemistry 2013 May 3;288(18):12880-90
The Journal of biological chemistry 2013 May 3;288(18):12880-90
Ceramide synthase 6 knockdown suppresses apoptosis after photodynamic therapy in human head and neck squamous carcinoma cells.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI
Anticancer research 2012 Mar;32(3):753-60
Anticancer research 2012 Mar;32(3):753-60
siRNA-mediated down-regulation of ceramide synthase 1 leads to apoptotic resistance in human head and neck squamous carcinoma cells after photodynamic therapy.
Separovic D, Breen P, Joseph N, Bielawski J, Pierce JS, VAN Buren E, Gudz TI
Anticancer research 2012 Jul;32(7):2479-2485
Anticancer research 2012 Jul;32(7):2479-2485
Alteration of ceramide synthase 6/C16-ceramide induces activating transcription factor 6-mediated endoplasmic reticulum (ER) stress and apoptosis via perturbation of cellular Ca2+ and ER/Golgi membrane network.
Senkal CE, Ponnusamy S, Manevich Y, Meyers-Needham M, Saddoughi SA, Mukhopadyay A, Dent P, Bielawski J, Ogretmen B
The Journal of biological chemistry 2011 Dec 9;286(49):42446-58
The Journal of biological chemistry 2011 Dec 9;286(49):42446-58
Antiapoptotic roles of ceramide-synthase-6-generated C16-ceramide via selective regulation of the ATF6/CHOP arm of ER-stress-response pathways.
Senkal CE, Ponnusamy S, Bielawski J, Hannun YA, Ogretmen B
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jan;24(1):296-308
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jan;24(1):296-308
The BCL-2 protein BAK is required for long-chain ceramide generation during apoptosis.
Siskind LJ, Mullen TD, Romero Rosales K, Clarke CJ, Hernandez-Corbacho MJ, Edinger AL, Obeid LM
The Journal of biological chemistry 2010 Apr 16;285(16):11818-26
The Journal of biological chemistry 2010 Apr 16;285(16):11818-26
Ceramide synthase 6 modulates TRAIL sensitivity and nuclear translocation of active caspase-3 in colon cancer cells.
White-Gilbertson S, Mullen T, Senkal C, Lu P, Ogretmen B, Obeid L, Voelkel-Johnson C
Oncogene 2009 Feb 26;28(8):1132-41
Oncogene 2009 Feb 26;28(8):1132-41
Role of human longevity assurance gene 1 and C18-ceramide in chemotherapy-induced cell death in human head and neck squamous cell carcinomas.
Senkal CE, Ponnusamy S, Rossi MJ, Bialewski J, Sinha D, Jiang JC, Jazwinski SM, Hannun YA, Ogretmen B
Molecular cancer therapeutics 2007 Feb;6(2):712-22
Molecular cancer therapeutics 2007 Feb;6(2):712-22
JNK3 signaling pathway activates ceramide synthase leading to mitochondrial dysfunction.
Yu J, Novgorodov SA, Chudakova D, Zhu H, Bielawska A, Bielawski J, Obeid LM, Kindy MS, Gudz TI
The Journal of biological chemistry 2007 Aug 31;282(35):25940-9
The Journal of biological chemistry 2007 Aug 31;282(35):25940-9
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Supportive validation
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LASS6 Antibody [H00253782-A01] - LASS6 polyclonal antibody (A01) Western Blot analysis of LASS6 expression in IMR-32.
- Submitted by
- Novus Biologicals (provider)
- Main image
- Experimental details
- Western Blot: LASS6 Antibody [H00253782-A01] - Detection against Immunogen (33.81 KDa) .
