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Learn55290-1-AP
antibody from Proteintech Group
Targeting: FBXW7
AGO, CDC4, FBW7, FBX30, FBXW6, FLJ11071, SEL-10, SEL10
Western blot
ELISAAntibody data
- Antibody Data
- Antigen structure
- References [21]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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- Product number
- 55290-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- FBXW7 antibody
- Antibody type
- Polyclonal
- Description
- FBXW7 antibody (Cat. #55290-1-AP) is a rabbit polyclonal antibody that shows reactivity with human and has been validated for the following applications: IF, IHC, WB, ELISA.
- Reactivity
- Human
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references Cell-based high-throughput screening using a target-NanoLuc fusion construct to identify molecular glue degraders of c-Myc oncoprotein.
CREM-activated LTBP1 transcription promotes radioresistance and immune escape in triple-negative breast cancer.
Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies.
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
The HTLV-I oncoprotein Tax inactivates the tumor suppressor FBXW7.
CircNCX1 modulates cardiomyocyte proliferation through promoting ubiquitination of BRG1.
FBXO8 is a novel prognostic biomarker in different molecular subtypes of breast cancer and suppresses breast cancer progression by targeting c-MYC.
F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway.
The interface targeting hnRNPA2B1 regulates the repression of transthyretin against human retinal microvascular endothelial cells in high-glucose environment.
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal.
Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication.
Demethylzeylasteral inhibits proliferation, migration, and invasion through FBXW7/c-Myc axis in gastric cancer.
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1.
Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.
Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway.
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.
Xu M, Qiu J, Tan L, Xu J, Wang Y, Kong W, Liao H, Chen A, Chen X, Zhang J, Chiu CKC, Zhang M, Tian Y, Li C, Ma B, Wang L, Fu J, Choi SH, Hill J, Shen W
RSC chemical biology 2025 Oct 29;6(11):1759-1771
RSC chemical biology 2025 Oct 29;6(11):1759-1771
CREM-activated LTBP1 transcription promotes radioresistance and immune escape in triple-negative breast cancer.
Zhao B, Ge X, Du P, Zhang M, Jiang M, Deng M, Wang P, Dong L, Wang W, Wang D, Mi X, Liu Y, Qiu X
Biochemical pharmacology 2025 Nov;241:117172
Biochemical pharmacology 2025 Nov;241:117172
Sorafenib promotes the E3 ubiquitin ligase FBXW7 to increase tau degradation and ameliorate tauopathies.
Zhou Y, Wang Y, Yang H, Zhang C, Meng J, Zhang L, Li K, Huang LL, Zhang X, Luo H, Zhang Y
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5817-5831
Acta pharmaceutica Sinica. B 2025 Nov;15(11):5817-5831
Deciphering the molecular mechanism of YY1/HIF1A modulating ovarian cancer angiogenesis based on single-cell transcriptomics technology.
Quan X, Yi H, Huang M, Chen D
Mutation research 2025 Jul-Dec;831:111916
Mutation research 2025 Jul-Dec;831:111916
CREG1 attenuates doxorubicin-induced cardiotoxicity by inhibiting the ferroptosis of cardiomyocytes.
Liu D, Cheng X, Wu H, Song H, Bu Y, Wang J, Zhang X, Yan C, Han Y
Redox biology 2024 Sep;75:103293
Redox biology 2024 Sep;75:103293
ARMCX1 inhibits lung adenocarcinoma progression by recruiting FBXW7 for c-Myc degradation.
Hu Z, Wu Y, Sun X, Tong Y, Qiu H, Zhuo E
Biology direct 2024 Sep 16;19(1):82
Biology direct 2024 Sep 16;19(1):82
The HTLV-I oncoprotein Tax inactivates the tumor suppressor FBXW7.
Bellon M, Yeh C-h, Bai XT, Nicot C
Journal of virology 2024 Jul 23;98(7):e0040524
Journal of virology 2024 Jul 23;98(7):e0040524
CircNCX1 modulates cardiomyocyte proliferation through promoting ubiquitination of BRG1.
Yijian L, Weihan S, Lin Y, Heng Z, Yu W, Lin S, Shuo M, Mengyang L, Jianxun W
Cellular signalling 2024 Aug;120:111193
Cellular signalling 2024 Aug;120:111193
FBXO8 is a novel prognostic biomarker in different molecular subtypes of breast cancer and suppresses breast cancer progression by targeting c-MYC.
Khan AJ, Man S, Abbas M, Liu S, Zhang F
Biochimica et biophysica acta. General subjects 2024 Apr;1868(4):130577
Biochimica et biophysica acta. General subjects 2024 Apr;1868(4):130577
F-box and WD repeat domain containing 7 inhibits the activation of hepatic stellate cells by degrading delta-like ligand 1 to block Notch signaling pathway.
Sun Y, He L, Guo P, Li F, Wang B, Zhang Y, An K, Peng M
Open medicine (Warsaw, Poland) 2023;18(1):20230634
Open medicine (Warsaw, Poland) 2023;18(1):20230634
The interface targeting hnRNPA2B1 regulates the repression of transthyretin against human retinal microvascular endothelial cells in high-glucose environment.
Tian Y, Ye L, Shao J, Xin Y
Diabetic medicine : a journal of the British Diabetic Association 2023 Sep;40(9):e15125
Diabetic medicine : a journal of the British Diabetic Association 2023 Sep;40(9):e15125
RUNX3 inactivates oncogenic MYC through disruption of MYC/MAX complex and subsequent recruitment of GSK3β-FBXW7 cascade.
Oei V, Chuang LSH, Matsuo J, Srivastava S, Teh M, Ito Y
Communications biology 2023 Jul 3;6(1):689
Communications biology 2023 Jul 3;6(1):689
Polycomb repressive complex 2 binds and stabilizes NANOG to suppress differentiation-related genes to promote self-renewal.
Yeh DW, Liu C, Hernandez JC, Tahara SM, Tsukamoto H, Machida K
iScience 2023 Jul 21;26(7):107035
iScience 2023 Jul 21;26(7):107035
Cyclin E-induced replicative stress drives p53-dependent whole-genome duplication.
Zeng J, Hills SA, Ozono E, Diffley JFX
Cell 2023 Feb 2;186(3):528-542.e14
Cell 2023 Feb 2;186(3):528-542.e14
Demethylzeylasteral inhibits proliferation, migration, and invasion through FBXW7/c-Myc axis in gastric cancer.
Li Y, Su Y, Zhao Y, Hu X, Zhao G, He J, Wan S, Lü M, Cui H
MedComm 2021 Sep;2(3):467-480
MedComm 2021 Sep;2(3):467-480
The deubiquitinase USP38 promotes cell proliferation through stabilizing c-Myc.
Xu Z, Hu H, Fang D, Wang J, Zhao K
The international journal of biochemistry & cell biology 2021 Aug;137:106023
The international journal of biochemistry & cell biology 2021 Aug;137:106023
E3 ligase Fbw7 participates in oxidative stress‑induced myocardial cell injury via interacting with Mcl‑1.
Li X, Zhang N, Zhang Y, Jia P, Guo Y, Tian Y, You S, Wu S, Sun Y
Molecular medicine reports 2019 Aug;20(2):1561-1568
Molecular medicine reports 2019 Aug;20(2):1561-1568
Inhibition of the prolyl isomerase Pin1 enhances the ability of sorafenib to induce cell death and inhibit tumor growth in hepatocellular carcinoma.
Zheng M, Xu H, Liao XH, Chen CP, Zhang AL, Lu W, Wang L, Yang D, Wang J, Liu H, Zhou XZ, Lu KP
Oncotarget 2017 May 2;8(18):29771-29784
Oncotarget 2017 May 2;8(18):29771-29784
Sensitivity of non-small cell lung cancer to erlotinib is regulated by the Notch/miR-223/FBXW7 pathway.
Zhang H, Chen F, He Y, Yi L, Ge C, Shi X, Tang C, Wang D, Wu Y, Nian W
Bioscience reports 2017 Jun 30;37(3)
Bioscience reports 2017 Jun 30;37(3)
Targeted inhibition of the COP9 signalosome for treatment of cancer.
Schlierf A, Altmann E, Quancard J, Jefferson AB, Assenberg R, Renatus M, Jones M, Hassiepen U, Schaefer M, Kiffe M, Weiss A, Wiesmann C, Sedrani R, Eder J, Martoglio B
Nature communications 2016 Oct 24;7:13166
Nature communications 2016 Oct 24;7:13166
Rictor Regulates Spermatogenesis by Controlling Sertoli Cell Cytoskeletal Organization and Cell Polarity in the Mouse Testis.
Dong H, Chen Z, Wang C, Xiong Z, Zhao W, Jia C, Lin J, Lin Y, Yuan W, Zhao AZ, Bai X
Endocrinology 2015 Nov;156(11):4244-56
Endocrinology 2015 Nov;156(11):4244-56
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- human brain tissue were subjected to SDS PAGE followed by western blot with 55290-1-AP(FBXW7 antibody) at dilution of 1:600
- Sample type
- tissue
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- The FBXW7 antibody from Proteintech is a rabbit polyclonal antibody to a peptide of human FBXW7. This antibody recognizes human, mouse antigen. The FBXW7 antibody has been validated for the following applications: ELISA, WB, IHC analysis.
