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- References [131]
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- Product number
- 24050-1-AP - Provider product page
- Provider
- Proteintech Group
- Product name
- Glucocorticoid receptor antibody
- Antibody type
- Polyclonal
- Description
- KD/KO validated Glucocorticoid receptor antibody (Cat. #24050-1-AP) is a rabbit polyclonal antibody that shows reactivity with human, mouse, rat and has been validated for the following applications: IF, IHC, IP, WB,ELISA.
- Reactivity
- Human, Mouse, Rat
- Host
- Rabbit
- Conjugate
- Unconjugated
- Isotype
- IgG
- Vial size
- 20ul, 150ul
Submitted references 20(R)-Rg3 derived from ginseng fibrous roots ameliorates DSS-induced colitis via selective modulation of glucocorticoid receptor signaling.
Xin-Ji-Er-Kang alleviates chronic heart failure by suppressing mtDNA/cGAS-STING signaling through NR3C1-mediated MFN2 upregulation.
Honghua Xiaoyao tablets ameliorate premenstrual syndrome by modulating HPA axis and restoring ovarian estrogen synthesis to attenuate hippocampal neuroinflammation.
Zhichi Suanzaoren Decoction alleviates perimenopausal insomnia via restoring astrocytic primary cilia and modulating Wnt/GSK-3β/GR signaling axis.
Lp-PLA2-derived LysoPC drives dendritic cell immunogenic activation and Th17 inflammation in severe asthma.
Combinational Analysis of Metabolomic and O-GlcNAcylation Omics Reveals the HBP Metabolic Regulation of Chemoresistance via GFPT1/NR3C1 O-GlcNAcylation/GPX4 Axis.
ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification.
Chronic stress-induced downregulation of MFN1 contributes to fatty liver in chickens.
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Glucocorticoid Receptor and SUMO Fluctuations in Response to Pulsatile Glucocorticoids In Vitro and in Male Rat Brains.
Stress induces corticosterone-mediated CD8(+) T cell exhaustion to promote non-small cell lung cancer.
Acute antilipolytic effects of elevated levels of corticosterone in differentiated murine white adipocytes.
Helicobacter pylori modulates macrophage polarization via the glucocorticoid receptor to promote gastric cancer cell proliferation.
Molecular mechanism of the crosstalk between glucocorticoid receptor (GR) and hypoxia-inducible factor 3α (HIF-3α) pathways.
Pulchinenoside E2: A dual-functional STAT3 and autophagy inhibitor with potent anti-metastatic activity in triple-negative breast cancer.
Sex-Specific Involvement of Gut Microbiota in Behavioral and Endocrine Responses to Chronic Predator Odor in Brandt's Voles.
Vagal pathway activation links chronic stress to decline in intestinal stem cell function.
miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA.
Glucocorticoid receptor-targeting antagomirs alleviates AFB1-induced hepatotoxicity in mice.
Corticosterone induces fatty liver syndrome in chickens via glucocorticoid receptor and inhibition of mitochondrial supercomplex formation.
Single-Cell Transcriptomic Analysis Reveals Biomechanical Loading-Induced Imbalance in Bone and Fat, Leading to Ossification in Lumbar Intervertebral Disc Nucleus Pulposus Degeneration.
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Repeated stress gradually impairs auditory processing and perception.
Pachymic Acid Suppresses Endometrial Cancer Cell Migration by Inhibiting the NR3C1/TGF-β/Smad Signaling Pathway.
Glucocorticoid inhibits lung cancer cells proliferation and migration by suppressing smad2/3 activation.
Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms.
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Tanshinone IIA improved psychological stress-induced embryo implantation disorders by inhibiting GC/GR signaling and promoting angiogenesis.
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
Upregulation of ferroptosis in glucocorticoids-induced posterior subcapsular cataracts.
An Optimized High-Resolution Mapping Method for Glucocorticoid Receptor-DNA Binding in Mouse Primary Macrophages.
Glucocorticoid Receptor-Dependent Binding Analysis Using Chromatin Immunoprecipitation and Quantitative Polymerase Chain Reaction.
Histological analysis of glucocorticoid receptor and eosinophilic cytokines in the adenoid mucosal epithelium.
Diosgenin alleviates arsenic trioxide induced cardiac fibrosis by inhibiting endothelial mesenchymal transition.
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head.
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.
The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes.
Traditional Pediatric Massage Enhanced Hippocampal GR, BDNF and IGF-1 Expressions and Exerted an Anti-depressant Effect in an Adolescent Rat Model of CUMS-induced Depression.
Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth.
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Intermittent Fasting-Improved Glucose Homeostasis Is Not Entirely Dependent on Caloric Restriction in db/db Male Mice.
Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4.
Depression Exacerbates Hepatic Steatosis in C57BL/6J Mice by Activating the Hypothalamic-Pituitary-Adrenal Axis.
Dendrobine Ameliorates Glucocorticoid-Induced Osteoporosis by Promoting Osteogenesis through JNK/p38 MAPK Pathway Activation and GR Nuclear Translocation Inhibition.
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells.
Remote modulation of WWOX by an intronic variant associated with survival of Chinese gastric cancer patients.
Lactobacillus reuteri or Lactobacillus rhamnosus GG intervention facilitates gut barrier function, decreases corticosterone and ameliorates social behavior in LPS-exposed offspring.
Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice.
PERK inhibitor (ISRIB) improves depression-like behavior by inhibitions of HPA-axis over-activation in mice exposed to chronic restraint stress.
Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish.
Stress during pubertal development affects female sociosexual behavior in mice.
Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression.
Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice.
Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.
Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain.
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes.
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
Chronic Corticosterone Exposure Suppresses Copper Transport through GR-Mediated Intestinal CTR1 Pathway in Mice.
LncRNA Ctcflos modulates glucocorticoid receptor-mediated induction of hepatic phosphoenolpyruvate carboxykinase in mice.
The effect of cold exposure on the levels of glucocorticoids, 11-hydroxysteroid dehydrogenase 2, and placental vascularization in a rat model.
The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia.
Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance.
The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1.
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation.
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia.
Monochromatic Light Pollution Exacerbates High-Fat Diet-Induced Adipocytic Hypertrophy in Mice.
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.
Two-hour acute restraint stress facilitates escape behavior and learning outcomes through the activation of the Cdk5/GR P S211 pathway in male mice.
Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway.
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.
HNF4A modulates glucocorticoid action in the liver.
Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer.
Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell.
Hair growth predicts a depression-like phenotype in rats as a mirror of stress traceability.
Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells.
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis.
SRC-1 Deficiency Increases Susceptibility of Mice to Depressive-Like Behavior After Exposure to CUMS.
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice.
Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons.
The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
Sensitivity to behavioral stress impacts disease pathogenesis in dystrophin-deficient mice.
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance.
Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors.
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids.
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.
Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation.
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway.
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta.
MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR.
The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder.
Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107.
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.
Gestational stress induced differential expression of HDAC2 in male rat offspring hippocampus during development.
Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet.
Response of the maternal hypothalamus to cold stress during late pregnancy in rats.
An improved method for quantitative ChIP studies of nuclear receptor function.
Sericin Nerve Guidance Conduit Delivering Therapeutically Repurposed Clobetasol for Functional and Structural Regeneration of Transected Peripheral Nerves.
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
E47 modulates hepatic glucocorticoid action.
Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats.
Differences of physical vs. psychological stress: evidences from glucocorticoid receptor expression, hippocampal subfields injury, and behavioral abnormalities.
REVERBa couples the circadian clock to hepatic glucocorticoid action.
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells.
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response.
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1.
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling.
Redox homeostasis protects mitochondria through accelerating ROS conversion to enhance hypoxia resistance in cancer cells.
HOXA13 exerts a beneficial effect in albumin-induced epithelial-mesenchymal transition via the glucocorticoid receptor signaling pathway in human renal tubular epithelial cells.
The secretion, synthesis, and metabolism of cortisol and its downstream genes in the H-P-I axis of rare minnows (Gobiocypris rarus) are disrupted by acute waterborne cadmium exposure.
Glucocorticoid receptor regulates accurate chromosome segregation and is associated with malignancy.
Dihydrocapsaicin Attenuates Plaque Formation through a PPARγ/LXRα Pathway in apoE(-/-) Mice Fed a High-Fat/High-Cholesterol Diet.
Pin1 promotes GR transactivation by enhancing recruitment to target genes.
Kong X, Wang P, Zhang S, Kou L, Tan M, Xie Z, Guo W
Naunyn-Schmiedeberg's archives of pharmacology 2026 May 1;
Naunyn-Schmiedeberg's archives of pharmacology 2026 May 1;
Xin-Ji-Er-Kang alleviates chronic heart failure by suppressing mtDNA/cGAS-STING signaling through NR3C1-mediated MFN2 upregulation.
Zhang R, Wu J, Wang D, Li K, Hou Y, Yu Y, Jin C, Wang C, Gao S
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157714
Phytomedicine : international journal of phytotherapy and phytopharmacology 2026 Jan;150:157714
Honghua Xiaoyao tablets ameliorate premenstrual syndrome by modulating HPA axis and restoring ovarian estrogen synthesis to attenuate hippocampal neuroinflammation.
Chen K, Gao S, Cai B, Ma Z, Liu X, Chen W, Lin N, Zhang Y
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120688
Journal of ethnopharmacology 2026 Jan 30;355(Pt B):120688
Zhichi Suanzaoren Decoction alleviates perimenopausal insomnia via restoring astrocytic primary cilia and modulating Wnt/GSK-3β/GR signaling axis.
Zhang Z, Liu Y, Zhao B, Fu H, Wang J, Zhang M, Zhang Y, Hu L, Zhang X
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120631
Journal of ethnopharmacology 2026 Jan 30;355(Pt A):120631
Lp-PLA2-derived LysoPC drives dendritic cell immunogenic activation and Th17 inflammation in severe asthma.
Wang F, Min Z, Qian Y, Gao J, Yang Z, Jiang Z, Chen Z
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 28;75(1)
Inflammation research : official journal of the European Histamine Research Society ... [et al.] 2026 Apr 28;75(1)
Combinational Analysis of Metabolomic and O-GlcNAcylation Omics Reveals the HBP Metabolic Regulation of Chemoresistance via GFPT1/NR3C1 O-GlcNAcylation/GPX4 Axis.
Zhou X, Zhang C, Li L, Feng Z, Bai X, Mei Y, He W, Gou X, Li X
Research (Washington, D.C.) 2025;8:0809
Research (Washington, D.C.) 2025;8:0809
ITGA4 Contributes to 5-Fluorouracil Resistance by Up-Regulating PI3K/AKT Signaling: Evidence from Network Pharmacology, Molecular Docking and Experimental Verification.
Yan S, Hu X, Wu Y, Ye W, Zhu Y, He Y, Zhan F, Wu W, Ma Z
Drug design, development and therapy 2025;19:4105-4122
Drug design, development and therapy 2025;19:4105-4122
Chronic stress-induced downregulation of MFN1 contributes to fatty liver in chickens.
Zhang K, Yu H, Chen H, Guan Z, Wang X, Liu J, Zhao M, Zhao R, Yang D, Wu L
Frontiers in veterinary science 2025;12:1646921
Frontiers in veterinary science 2025;12:1646921
Chronic Psychological Stress Induces Cardiomyocyte Hypertrophy Through Corticosterone-Glucocorticoid Receptor-LAMA5 Axis.
Zhang C, Song Y, Jin X, Xu Q, Ye H, Wu Z, Lin H, Hu J, Huang C, Zhou J, Lian J
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Advanced science (Weinheim, Baden-Wurttemberg, Germany) 2025 Sep;12(36):e14659
Glucocorticoid Receptor and SUMO Fluctuations in Response to Pulsatile Glucocorticoids In Vitro and in Male Rat Brains.
Rivers CA, Abdulqayoom HA, Kershaw YM, Troy OR, Zhao Z, Conway-Campbell BL, Lightman SL
Endocrinology 2025 Sep 8;166(10)
Endocrinology 2025 Sep 8;166(10)
Stress induces corticosterone-mediated CD8(+) T cell exhaustion to promote non-small cell lung cancer.
Zheng Q, Zhuoga J, Weng Q, Zhang H, Deng L, Yalikun M, Fu P, Dong Z, Dong J
Cancer immunology, immunotherapy : CII 2025 Sep 29;74(10):316
Cancer immunology, immunotherapy : CII 2025 Sep 29;74(10):316
Acute antilipolytic effects of elevated levels of corticosterone in differentiated murine white adipocytes.
Mir N, Lyons SA, Guo Z, Mirza SK, Tan W, Peckett AJ, Beaudry JL
American journal of physiology. Cell physiology 2025 Sep 1;329(3):C972-C985
American journal of physiology. Cell physiology 2025 Sep 1;329(3):C972-C985
Helicobacter pylori modulates macrophage polarization via the glucocorticoid receptor to promote gastric cancer cell proliferation.
Wang X, Weng Y, Yao Y, Shao S, Mao L, Wang J
Tissue & cell 2025 Oct;96:103001
Tissue & cell 2025 Oct;96:103001
Molecular mechanism of the crosstalk between glucocorticoid receptor (GR) and hypoxia-inducible factor 3α (HIF-3α) pathways.
Zhang M, Guo Y, Diao X, Guo M, Teng H, Sun X, Zhuang J, Song C, Xie X, Wu D
Marine life science & technology 2025 Nov;7(4):779-791
Marine life science & technology 2025 Nov;7(4):779-791
Pulchinenoside E2: A dual-functional STAT3 and autophagy inhibitor with potent anti-metastatic activity in triple-negative breast cancer.
Zheng D, Shu J, Gao B, Yu H, Liu K, Zheng M, Liu X, Chen G, Lin Y, Li Q, Sun Y, Zheng Y, Li B, Yang X, Wang K
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157485
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Nov 25;148:157485
Sex-Specific Involvement of Gut Microbiota in Behavioral and Endocrine Responses to Chronic Predator Odor in Brandt's Voles.
Gu C, Xu R, Yin B, Wu R, Wei Y, Wang D, Wei W
Integrative zoology 2025 Nov 11;
Integrative zoology 2025 Nov 11;
Vagal pathway activation links chronic stress to decline in intestinal stem cell function.
Zhang G, Lian Y, Li Q, Zhou S, Zhang L, Chen L, Tang J, Liu H, Li N, Pan Q, Gu Y, Lin N, Wang H, Wang X, Guo J, Zhang W, Jin Z, Xu B, Su X, Lin M, Han Q, Qin J
Cell stem cell 2025 May 1;32(5):778-794.e10
Cell stem cell 2025 May 1;32(5):778-794.e10
miR124a-3p inhibitor alleviates AFB1-induced hepatoxicity via targeting chicken glucocorticoid receptor mRNA.
Zhao M, Chen L, Zhao Y, Liu J, Chen H, Zhao R
Poultry science 2025 Mar;104(3):104841
Poultry science 2025 Mar;104(3):104841
Glucocorticoid receptor-targeting antagomirs alleviates AFB1-induced hepatotoxicity in mice.
Zhao M, Zhao Y, Liu J, Chen H, Zhao R
Ecotoxicology and environmental safety 2025 Mar 1;292:117935
Ecotoxicology and environmental safety 2025 Mar 1;292:117935
Corticosterone induces fatty liver syndrome in chickens via glucocorticoid receptor and inhibition of mitochondrial supercomplex formation.
Chen H, Zhang K, Yu H, Guan Z, Zhao R, Wu L
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Jun 1;328(6):R770-R782
American journal of physiology. Regulatory, integrative and comparative physiology 2025 Jun 1;328(6):R770-R782
Single-Cell Transcriptomic Analysis Reveals Biomechanical Loading-Induced Imbalance in Bone and Fat, Leading to Ossification in Lumbar Intervertebral Disc Nucleus Pulposus Degeneration.
Zhang P, Wang Y, Bai J, Zhang J, Zhang S, Guo X, Zhan J, Zhu L
Journal of cellular physiology 2025 Jan;240(1):e31506
Journal of cellular physiology 2025 Jan;240(1):e31506
Targeting EGFR-binding protein SLC7A11 enhancing antitumor immunity of T cells via inducing MHC-I antigen presentation in nasopharyngeal carcinoma.
Wang H, Fan S, Zhan Y, Xu Y, Du Y, Luo J, Zang H, Peng S, Wang W
Cell death & disease 2025 Jan 16;16(1):21
Cell death & disease 2025 Jan 16;16(1):21
Repeated stress gradually impairs auditory processing and perception.
Bisharat G, Kaganovski E, Sapir H, Temnogorod A, Levy T, Resnik J
PLoS biology 2025 Feb;23(2):e3003012
PLoS biology 2025 Feb;23(2):e3003012
Pachymic Acid Suppresses Endometrial Cancer Cell Migration by Inhibiting the NR3C1/TGF-β/Smad Signaling Pathway.
Wang Y, Ma L
Chemical biology & drug design 2025 Dec;106(6):e70226
Chemical biology & drug design 2025 Dec;106(6):e70226
Glucocorticoid inhibits lung cancer cells proliferation and migration by suppressing smad2/3 activation.
Xu L, Li Q, Xu C, Tan D, Tan Y
Scientific reports 2025 Dec 8;16(1):36
Scientific reports 2025 Dec 8;16(1):36
Hepatic metabolic reprogramming in male mice during short-term caloric restriction involves enhanced glucocorticoid rhythms.
Makris K, Fonda V, Ramadhani FF, Fadel L, Davezac M, Payet B, Deligiannis IK, Zhang L, Horn T, Heimerl L, Jouffe C, Heddes M, Martinez-Jimenez CP, Quagliarini F, Uhlenhaut NH
Nature communications 2025 Dec 11;16(1):11106
Nature communications 2025 Dec 11;16(1):11106
Sirtuin 1-mediated recruitment of non-structural protein 1 to glucocorticoid receptor induces glucocorticoid insensitivity post RSV infection.
Che S, Long X, Mo S, Jiang Z, Xie X, Liu E, Xie J
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
International journal of biological macromolecules 2025 Aug;320(Pt 1):145811
Tanshinone IIA improved psychological stress-induced embryo implantation disorders by inhibiting GC/GR signaling and promoting angiogenesis.
Li F, Zhao S, Fang Q, Qiao Z, Meng Y, Jin Q, Zong L, Shui L, Chen S, Han H, Wang J, Wu L
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156946
Phytomedicine : international journal of phytotherapy and phytopharmacology 2025 Aug;144:156946
NR3C1/GLMN-Mediated FKBP12.6 Ubiquitination Disrupts Calcium Homeostasis and Impairs Mitochondrial Quality Control in Stress-Induced Myocardial Damage.
Cong J, Liu L, Shi R, He M, An Y, Feng X, Yin X, Li Y, Cong B, Shi W
International journal of molecular sciences 2025 Aug 25;26(17)
International journal of molecular sciences 2025 Aug 25;26(17)
Upregulation of ferroptosis in glucocorticoids-induced posterior subcapsular cataracts.
Zhang Y, Si W, Mao Y, Xu S, Li F, Liu J, Du S, Shao J, Qi Y, Peng X, Xue M, Jiang M, Guo K, Hu Y, Zhang F
Communications biology 2025 Apr 15;8(1):613
Communications biology 2025 Apr 15;8(1):613
An Optimized High-Resolution Mapping Method for Glucocorticoid Receptor-DNA Binding in Mouse Primary Macrophages.
Ansari SA, Uhlenhaut NH
Methods in molecular biology (Clifton, N.J.) 2024;2846:91-107
Methods in molecular biology (Clifton, N.J.) 2024;2846:91-107
Glucocorticoid Receptor-Dependent Binding Analysis Using Chromatin Immunoprecipitation and Quantitative Polymerase Chain Reaction.
Nalbantoglu D, Preuss JM, Vettorazzi S
Methods in molecular biology (Clifton, N.J.) 2024;2846:17-34
Methods in molecular biology (Clifton, N.J.) 2024;2846:17-34
Histological analysis of glucocorticoid receptor and eosinophilic cytokines in the adenoid mucosal epithelium.
Tochigi K, Omura K, Hattori S, Asako M, Tanaka Y
International journal of pediatric otorhinolaryngology 2024 Sep;184:112079
International journal of pediatric otorhinolaryngology 2024 Sep;184:112079
Diosgenin alleviates arsenic trioxide induced cardiac fibrosis by inhibiting endothelial mesenchymal transition.
Cui H, Xu W, Liu L, Hong Y, Lou H, Tang P, Lin Y, Xu H, Xie M, Du M, Tang X, Wang Z, Wang Q, Zhang Y
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155891
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Sep;132:155891
Inhibition of sympathetic tone via hypothalamic descending pathway propagates glucocorticoid-induced endothelial impairment and osteonecrosis of the femoral head.
Shao W, Wang B, Wang P, Zhang S, Gong S, Guo X, Duan D, Shao Z, Liu W, He L, Gao F, Lv X, Feng Y
Bone research 2024 Nov 8;12(1):64
Bone research 2024 Nov 8;12(1):64
Tanshinone IIA potentiates the therapeutic efficacy of glucocorticoids in lipopolysaccharide-treated HEI-OC1 cells through modulation of the FOXP3/Nrf2 signaling pathway.
Li J, Zhu X, Ye S, Dong Q, Hou J, Liu J, She W
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
Acta biochimica et biophysica Sinica 2024 Nov 1;57(5):727-737
Shen Yuan extract exerts a hypnotic effect via the tryptophan/5-hydroxytryptamine/melatonin pathway in mice.
Xia TJ, Jin SW, Liu YG, Zhang SS, Wang Z, Liu XM, Pan RL, Jiang N, Liao YH, Yan MZ, Chang Q
Journal of ethnopharmacology 2024 May 23;326:117992
Journal of ethnopharmacology 2024 May 23;326:117992
The role of microRNA-142a in Toxoplasma gondii infection-induced downregulation of Foxp3: implications for adverse pregnancy outcomes.
Zhong Y, Cao Y, Geng X, Yang S, Qian T, Liu C, Chen J
BMC infectious diseases 2024 May 13;24(1):490
BMC infectious diseases 2024 May 13;24(1):490
Traditional Pediatric Massage Enhanced Hippocampal GR, BDNF and IGF-1 Expressions and Exerted an Anti-depressant Effect in an Adolescent Rat Model of CUMS-induced Depression.
Wu R, Xiong Y, Gu Y, Cao LY, Zhang SY, Song ZX, Fan P, Lin L
Neuroscience 2024 Mar 26;542:47-58
Neuroscience 2024 Mar 26;542:47-58
Cannabidiol Exposure During Rat Pregnancy Leads to Labyrinth-Specific Vascular Defects in the Placenta and Reduced Fetal Growth.
Allen S, Natale BV, Ejeckam AO, Lee K, Hardy DB, Natale DRC
Cannabis and cannabinoid research 2024 Jun;9(3):766-780
Cannabis and cannabinoid research 2024 Jun;9(3):766-780
Deciphering ER stress-unfolded protein response relationship by visualizing unfolded proteins in the ER.
Xu F, Wang L
Cell reports 2024 Jun 25;43(6):114358
Cell reports 2024 Jun 25;43(6):114358
CGG repeats in the human FMR1 gene regulate mRNA localization and cellular stress in developing neurons.
Sirois CL, Guo Y, Li M, Wolkoff NE, Korabelnikov T, Sandoval S, Lee J, Shen M, Contractor A, Sousa AMM, Bhattacharyya A, Zhao X
Cell reports 2024 Jun 25;43(6):114330
Cell reports 2024 Jun 25;43(6):114330
Intermittent Fasting-Improved Glucose Homeostasis Is Not Entirely Dependent on Caloric Restriction in db/db Male Mice.
Zheng D, Hong X, He X, Lin J, Fan S, Wu J, Liang Z, Chen S, Yan L, Ren M, Wang W
Diabetes 2024 Jun 1;73(6):864-878
Diabetes 2024 Jun 1;73(6):864-878
Ginsenoside Rg5 inhibits glioblastoma by activating ferroptosis via NR3C1/HSPB1/NCOA4.
Zhang G, Hu J, Li A, Zhang H, Guo Z, Li X, You Z, Wang Y, Jing Z
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155631
Phytomedicine : international journal of phytotherapy and phytopharmacology 2024 Jul;129:155631
Depression Exacerbates Hepatic Steatosis in C57BL/6J Mice by Activating the Hypothalamic-Pituitary-Adrenal Axis.
Su M, Yan Z, Wang Y, Cai J, Dong J, Luo J, Chen D, Liu A, Ye H
In vivo (Athens, Greece) 2024 Jul-Aug;38(4):1677-1689
In vivo (Athens, Greece) 2024 Jul-Aug;38(4):1677-1689
Dendrobine Ameliorates Glucocorticoid-Induced Osteoporosis by Promoting Osteogenesis through JNK/p38 MAPK Pathway Activation and GR Nuclear Translocation Inhibition.
Li X, Gao C, Zhou K, Gan K, Ye T, Zhao J, Li J, Ma C
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16739-16748
Journal of agricultural and food chemistry 2024 Jul 31;72(30):16739-16748
Cytoprotective effects of Hangekobokuto against corticosterone-induced cell death in HT22 cells.
Miyagishi H, Joyama A, Nango H, Nagayama K, Tsuji M, Takeda H, Kosuge Y
Journal of natural medicines 2024 Jan;78(1):255-265
Journal of natural medicines 2024 Jan;78(1):255-265
Remote modulation of WWOX by an intronic variant associated with survival of Chinese gastric cancer patients.
Cheng L, Chang Y, Xia Z, Liu Y, Liu X, Xiong L, Liu C, Zhu X, Wang M, Qiu L
International journal of cancer 2024 Jan 15;154(2):307-319
International journal of cancer 2024 Jan 15;154(2):307-319
Lactobacillus reuteri or Lactobacillus rhamnosus GG intervention facilitates gut barrier function, decreases corticosterone and ameliorates social behavior in LPS-exposed offspring.
Wang X, Hu R, Lin F, Yang T, Lu Y, Sun Z, Li T, Chen J
Food research international (Ottawa, Ont.) 2024 Dec;197(Pt 1):115212
Food research international (Ottawa, Ont.) 2024 Dec;197(Pt 1):115212
Sex and Age Differences in Glucocorticoid Signaling After an Aversive Experience in Mice.
Li Y, Zhang B, Yang Y, Su P, Samsom JN, Wong AHC, Liu F
Cells 2024 Dec 10;13(24)
Cells 2024 Dec 10;13(24)
PERK inhibitor (ISRIB) improves depression-like behavior by inhibitions of HPA-axis over-activation in mice exposed to chronic restraint stress.
Luhong L, Zhou HM, Tang XH, Chen J, Zhang AM, Zhou CL, Li SY, Wen Yu C, Liyan H, Xiang YY, Yang X
Behavioural brain research 2024 Aug 5;471:115122
Behavioural brain research 2024 Aug 5;471:115122
Elevated glucocorticoid alters the developmental dynamics of hypothalamic neurogenesis in zebrafish.
Eachus H, Choi MK, Tochwin A, Kaspareit J, Ho M, Ryu S
Communications biology 2024 Apr 5;7(1):416
Communications biology 2024 Apr 5;7(1):416
Stress during pubertal development affects female sociosexual behavior in mice.
Bentefour Y, Bakker J
Nature communications 2024 Apr 30;15(1):3610
Nature communications 2024 Apr 30;15(1):3610
Phase-shifting the circadian glucocorticoid profile induces disordered feeding behaviour by dysregulating hypothalamic neuropeptide gene expression.
Yoshimura M, Flynn BP, Kershaw YM, Zhao Z, Ueta Y, Lightman SL, Conway-Campbell BL
Communications biology 2023 Sep 29;6(1):998
Communications biology 2023 Sep 29;6(1):998
Betaine prevents cognitive dysfunction by suppressing hippocampal microglial activation in chronic social isolated male mice.
Shi MM, Xu XF, Sun QM, Luo M, Liu DD, Guo DM, Chen L, Zhong XL, Xu Y, Cao WY
Phytotherapy research : PTR 2023 Oct;37(10):4755-4770
Phytotherapy research : PTR 2023 Oct;37(10):4755-4770
Chronic psychological stress promotes breast cancer pre-metastatic niche formation by mobilizing splenic MDSCs via TAM/CXCL1 signaling.
Zheng Y, Wang N, Wang S, Zhang J, Yang B, Wang Z
Journal of experimental & clinical cancer research : CR 2023 May 20;42(1):129
Journal of experimental & clinical cancer research : CR 2023 May 20;42(1):129
Genomic regulation of Krüppel-like-factor family members by corticosteroid receptors in the rat brain.
Kennedy CLM, Price EM, Mifsud KR, Salatino S, Sharma E, Engledow S, Broxholme J, Goss HM, Reul JMHM
Neurobiology of stress 2023 Mar;23:100532
Neurobiology of stress 2023 Mar;23:100532
An Artemisia scoparia extract attenuates glucocorticoid-induced lipolysis in adipocytes.
Harvey I, Stephens JM
Obesity (Silver Spring, Md.) 2023 Jul;31(7):1859-1870
Obesity (Silver Spring, Md.) 2023 Jul;31(7):1859-1870
A plant-derived glucocorticoid receptor modulator with potency to attenuate the side effects of glucocorticoid therapy.
Wang Y, Gao J, Yu Y, Zhou L, Wang M, Xue W, Liu B, Wu X, Wu X, Gao H, Shen Y, Xu Q
British journal of pharmacology 2023 Jan;180(2):194-213
British journal of pharmacology 2023 Jan;180(2):194-213
Chronic Corticosterone Exposure Suppresses Copper Transport through GR-Mediated Intestinal CTR1 Pathway in Mice.
Guo S, Chen Z, Dong Y, Ni Y, Zhao R, Ma W
Biology 2023 Jan 28;12(2)
Biology 2023 Jan 28;12(2)
LncRNA Ctcflos modulates glucocorticoid receptor-mediated induction of hepatic phosphoenolpyruvate carboxykinase in mice.
Yoon JY, Kim JY, Kim HJ, Ka NL, Lee SH, Lee MO
Life sciences 2023 Jan 1;312:121254
Life sciences 2023 Jan 1;312:121254
The effect of cold exposure on the levels of glucocorticoids, 11-hydroxysteroid dehydrogenase 2, and placental vascularization in a rat model.
Zhang QJ, Chen SW, Xu X, Zhang HL, Yan JY
European review for medical and pharmacological sciences 2023 Dec;27(24):11961-11974
European review for medical and pharmacological sciences 2023 Dec;27(24):11961-11974
The crucial role of muscle glucocorticoid signaling in accelerating obesity and glucose intolerance via hyperinsulinemia.
Yamazaki H, Uehara M, Yoshikawa N, Kuribara-Souta A, Yamamoto M, Hirakawa Y, Kabe Y, Suematsu M, Tanaka H
JCI insight 2023 Apr 24;8(8)
JCI insight 2023 Apr 24;8(8)
Glucocorticoid activation of anti-inflammatory macrophages protects against insulin resistance.
Caratti G, Stifel U, Caratti B, Jamil AJM, Chung KJ, Kiehntopf M, Gräler MH, Blüher M, Rauch A, Tuckermann JP
Nature communications 2023 Apr 20;14(1):2271
Nature communications 2023 Apr 20;14(1):2271
The GR-gp78 Pathway is involved in Hepatic Lipid Accumulation Induced by Overexpression of 11β-HSD1.
Hu M, Han T, Pan Q, Ni D, Gao F, Wang L, Ren H, Zhang X, Jiao H, Wang Y, Dai D, Man Y, Tang W, Sun Y, Li W, Li J, Li G
International journal of biological sciences 2022;18(8):3107-3121
International journal of biological sciences 2022;18(8):3107-3121
Plasma Exosomes Transfer miR-885-3p Targeting the AKT/NFκB Signaling Pathway to Improve the Sensitivity of Intravenous Glucocorticoid Therapy Against Graves Ophthalmopathy.
Sun J, Wei J, Zhang Y, Li J, Li J, Yan J, Guo M, Han J, Qiao H
Frontiers in immunology 2022;13:819680
Frontiers in immunology 2022;13:819680
Effects of Poria cocos extract on metabolic dysfunction-associated fatty liver disease via the FXR/PPARα-SREBPs pathway.
He J, Yang Y, Zhang F, Li Y, Li X, Pu X, He X, Zhang M, Yang X, Yu Q, Qi Y, Li X, Yu J
Frontiers in pharmacology 2022;13:1007274
Frontiers in pharmacology 2022;13:1007274
Apelin-13 reduces lipopolysaccharide-induced neuroinflammation and cognitive impairment via promoting glucocorticoid receptor expression and nuclear translocation.
Hu S, Shen P, Chen B, Tian SW, You Y
Neuroscience letters 2022 Sep 25;788:136850
Neuroscience letters 2022 Sep 25;788:136850
P-Glycoprotein Aggravates Blood Brain Barrier Dysfunction in Experimental Ischemic Stroke by Inhibiting Endothelial Autophagy.
Huang L, Chen Y, Liu R, Li B, Fei X, Li X, Liu G, Li Y, Xu B, Fang W
Aging and disease 2022 Oct 1;13(5):1546-1561
Aging and disease 2022 Oct 1;13(5):1546-1561
Hypothalamic AgRP neurons exert top-down control on systemic TNF-α release during endotoxemia.
Boutagouga Boudjadja M, Culotta I, De Paula GC, Harno E, Hunter J, Cavalcanti-de-Albuquerque JP, Luckman SM, Hepworth M, White A, Aviello G, D'Agostino G
Current biology : CB 2022 Nov 7;32(21):4699-4706.e4
Current biology : CB 2022 Nov 7;32(21):4699-4706.e4
Monochromatic Light Pollution Exacerbates High-Fat Diet-Induced Adipocytic Hypertrophy in Mice.
Guan Q, Li Y, Wang Z, Cao J, Dong Y, Ren F, Chen Y
Cells 2022 Nov 28;11(23)
Cells 2022 Nov 28;11(23)
Comprehensive analysis of FKBP4/NR3C1/TMEM173 signaling pathway in triple-negative breast cancer cell and dendritic cell among tumor microenvironment.
Xiong H, Chen Z, Lin B, Chen W, Li Q, Li Y, Fang M, Wang Y, Zhang H, Lu Y, Bi A, Wu S, Jia Y, Wang X
Molecular therapy oncolytics 2022 Mar 17;24:371-384
Molecular therapy oncolytics 2022 Mar 17;24:371-384
A macrophage-hepatocyte glucocorticoid receptor axis coordinates fasting ketogenesis.
Loft A, Schmidt SF, Caratti G, Stifel U, Havelund J, Sekar R, Kwon Y, Sulaj A, Chow KK, Alfaro AJ, Schwarzmayr T, Rittig N, Svart M, Tsokanos FF, Maida A, Blutke A, Feuchtinger A, Møller N, Blüher M, Nawroth P, Szendrödi J, Færgeman NJ, Zeigerer A, Tuckermann J, Herzig S
Cell metabolism 2022 Mar 1;34(3):473-486.e9
Cell metabolism 2022 Mar 1;34(3):473-486.e9
Two-hour acute restraint stress facilitates escape behavior and learning outcomes through the activation of the Cdk5/GR P S211 pathway in male mice.
Wang B, Yang X, Lu J, Ntim M, Xia M, Kundu S, Jiang R, Chen D, Wang Y, Yang JY, Li S
Experimental neurology 2022 Aug;354:114023
Experimental neurology 2022 Aug;354:114023
Midkine promotes breast cancer cell proliferation and migration by upregulating NR3C1 expression and activating the NF-κB pathway.
Zhang L, Song L, Xu Y, Xu Y, Zheng M, Zhang P, Wang Q
Molecular biology reports 2022 Apr;49(4):2953-2961
Molecular biology reports 2022 Apr;49(4):2953-2961
Maternal stress programs a demasculinization of glutamatergic transmission in stress-related brain regions of aged rats.
Verhaeghe R, Gao V, Morley-Fletcher S, Bouwalerh H, Van Camp G, Cisani F, Nicoletti F, Maccari S
GeroScience 2022 Apr;44(2):1047-1069
GeroScience 2022 Apr;44(2):1047-1069
HNF4A modulates glucocorticoid action in the liver.
Hunter AL, Poolman TM, Kim D, Gonzalez FJ, Bechtold DA, Loudon ASI, Iqbal M, Ray DW
Cell reports 2022 Apr 19;39(3):110697
Cell reports 2022 Apr 19;39(3):110697
Network Pharmacology-Based Approach to Investigate the Molecular Targets of Sinomenine for Treating Breast Cancer.
Li XM, Li MT, Jiang N, Si YC, Zhu MM, Wu QY, Shi DC, Shi H, Luo Q, Yu B
Cancer management and research 2021;13:1189-1204
Cancer management and research 2021;13:1189-1204
Naringenin Regulates FKBP4/NR3C1/NRF2 Axis in Autophagy and Proliferation of Breast Cancer and Differentiation and Maturation of Dendritic Cell.
Xiong H, Chen Z, Lin B, Xie B, Liu X, Chen C, Li Z, Jia Y, Wu Z, Yang M, Jia Y, Wang L, Zhou J, Meng X
Frontiers in immunology 2021;12:745111
Frontiers in immunology 2021;12:745111
Hair growth predicts a depression-like phenotype in rats as a mirror of stress traceability.
Ren SY, Zhang YN, Wang MJ, Wen BR, Xia CY, Li X, Wang HQ, Zhang RP, Zhang Y, Wang ZZ, Chen NH
Neurochemistry international 2021 Sep;148:105110
Neurochemistry international 2021 Sep;148:105110
Discovery of a covalent inhibitor of heat shock protein 90 with antitumor activity that blocks the co-chaperone binding via C-terminal modification.
Li L, Chen N, Xia D, Xu S, Dai W, Tong Y, Wang L, Jiang Z, You Q, Xu X
Cell chemical biology 2021 Oct 21;28(10):1446-1459.e6
Cell chemical biology 2021 Oct 21;28(10):1446-1459.e6
ZNF598 co-translationally titrates poly(GR) protein implicated in the pathogenesis of C9ORF72-associated ALS/FTD.
Park J, Lee J, Kim JH, Lee J, Park H, Lim C
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Nucleic acids research 2021 Nov 8;49(19):11294-11311
Differential Effects of Fkbp4 and Fkbp5 on Regulation of the Proopiomelanocortin Gene in Murine AtT-20 Corticotroph Cells.
Kageyama K, Iwasaki Y, Watanuki Y, Niioka K, Daimon M
International journal of molecular sciences 2021 May 27;22(11)
International journal of molecular sciences 2021 May 27;22(11)
Oxidative stress in retrotrapezoid nucleus/parafacial respiratory group and impairment of central chemoreception in rat offspring exposed to maternal cigarette smoke.
Lei F, Wang W, Fu Y, Wang J, Zheng Y
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Reproductive toxicology (Elmsford, N.Y.) 2021 Mar;100:35-41
Honokiol Prevents Non-Alcoholic Steatohepatitis-Induced Liver Cancer via EGFR Degradation through the Glucocorticoid Receptor-MIG6 Axis.
Okuda K, Umemura A, Umemura S, Kataoka S, Taketani H, Seko Y, Nishikawa T, Yamaguchi K, Moriguchi M, Kanbara Y, Arbiser JL, Shima T, Okanoue T, Karin M, Itoh Y
Cancers 2021 Mar 25;13(7)
Cancers 2021 Mar 25;13(7)
SRC-1 Deficiency Increases Susceptibility of Mice to Depressive-Like Behavior After Exposure to CUMS.
Wu Q, Wang B, Ntim M, Zhang X, Na XY, Yuan YH, Wu XF, Yang JY, Li S
Neurochemical research 2021 Jul;46(7):1830-1843
Neurochemical research 2021 Jul;46(7):1830-1843
The co-chaperone Fkbp5 shapes the acute stress response in the paraventricular nucleus of the hypothalamus of male mice.
Häusl AS, Brix LM, Hartmann J, Pöhlmann ML, Lopez JP, Menegaz D, Brivio E, Engelhardt C, Roeh S, Bajaj T, Rudolph L, Stoffel R, Hafner K, Goss HM, Reul JMHM, Deussing JM, Eder M, Ressler KJ, Gassen NC, Chen A, Schmidt MV
Molecular psychiatry 2021 Jul;26(7):3060-3076
Molecular psychiatry 2021 Jul;26(7):3060-3076
Chronic glucocorticoid treatment induces hepatic lipid accumulation and hyperinsulinaemia in part through actions on AgRP neurons.
Harno E, Sefton C, Wray JR, Allen TJ, Davies A, Coll AP, White A
Scientific reports 2021 Jul 2;11(1):13776
Scientific reports 2021 Jul 2;11(1):13776
The glucocorticoid receptor recruits the COMPASS complex to regulate inflammatory transcription at macrophage enhancers.
Greulich F, Wierer M, Mechtidou A, Gonzalez-Garcia O, Uhlenhaut NH
Cell reports 2021 Feb 9;34(6):108742
Cell reports 2021 Feb 9;34(6):108742
Sensitivity to behavioral stress impacts disease pathogenesis in dystrophin-deficient mice.
Lindsay A, Trewin AJ, Sadler KJ, Laird C, Della Gatta PA, Russell AP
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22034
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2021 Dec;35(12):e22034
Glucocorticoid receptor regulates PD-L1 and MHC-I in pancreatic cancer cells to promote immune evasion and immunotherapy resistance.
Deng Y, Xia X, Zhao Y, Zhao Z, Martinez C, Yin W, Yao J, Hang Q, Wu W, Zhang J, Yu Y, Xia W, Yao F, Zhao D, Sun Y, Ying H, Hung MC, Ma L
Nature communications 2021 Dec 6;12(1):7041
Nature communications 2021 Dec 6;12(1):7041
Distinct regulation of hippocampal neuroplasticity and ciliary genes by corticosteroid receptors.
Mifsud KR, Kennedy CLM, Salatino S, Sharma E, Price EM, Haque SN, Gialeli A, Goss HM, Panchenko PE, Broxholme J, Engledow S, Lockstone H, Cordero Llana O, Reul JMHM
Nature communications 2021 Aug 6;12(1):4737
Nature communications 2021 Aug 6;12(1):4737
Individual-specific functional epigenomics reveals genetic determinants of adverse metabolic effects of glucocorticoids.
Hu W, Jiang C, Kim M, Yang W, Zhu K, Guan D, Lv W, Xiao Y, Wilson JR, Rader DJ, Pui CH, Relling MV, Lazar MA
Cell metabolism 2021 Aug 3;33(8):1592-1609.e7
Cell metabolism 2021 Aug 3;33(8):1592-1609.e7
Abnormal Glu/mGluR(2/3)/PI3K pathway in the hippocampal neurovascular unit leads to diabetes-related depression.
Liu J, Han YS, Liu L, Tang L, Yang H, Meng P, Zhao HQ, Wang YH
Neural regeneration research 2021 Apr;16(4):727-733
Neural regeneration research 2021 Apr;16(4):727-733
LRRK2 Inhibition Ameliorates Dexamethasone-Induced Glucose Intolerance via Prevents Impairment in GLUT4 Membrane Translocation in Adipocytes.
Imai M, Kawakami F, Kubo M, Kanzaki M, Maruyama H, Kawashima R, Maekawa T, Kurosaki Y, Kojima F, Ichikawa T
Biological & pharmaceutical bulletin 2020;43(11):1660-1668
Biological & pharmaceutical bulletin 2020;43(11):1660-1668
Anti-inflammatory functions of the glucocorticoid receptor require DNA binding.
Escoter-Torres L, Greulich F, Quagliarini F, Wierer M, Uhlenhaut NH
Nucleic acids research 2020 Sep 4;48(15):8393-8407
Nucleic acids research 2020 Sep 4;48(15):8393-8407
Small-molecule inhibitor targeting orphan nuclear receptor COUP-TFII for prostate cancer treatment.
Wang L, Cheng CM, Qin J, Xu M, Kao CY, Shi J, You E, Gong W, Rosa LP, Chase P, Scampavia L, Madoux F, Spicer T, Hodder P, Xu HE, Tsai SY, Tsai MJ
Science advances 2020 May;6(18):eaaz8031
Science advances 2020 May;6(18):eaaz8031
Maternal betaine protects rat offspring from glucocorticoid-induced activation of lipolytic genes in adipose tissue through modification of DNA methylation.
Zhao N, Yang S, Sun B, Feng Y, Zhao R
European journal of nutrition 2020 Jun;59(4):1707-1716
European journal of nutrition 2020 Jun;59(4):1707-1716
Rice Protein Exerts Endogenous Antioxidant Capacity via Methionine Sulfoxide Reductase and the Nrf2 Antioxidant System Independent of Age.
Li H, Liang M, Wang Z, Zhang Y, Wu Q, Yang L
Journal of medicinal food 2020 Jun;23(6):565-574
Journal of medicinal food 2020 Jun;23(6):565-574
Glucocorticoids rapidly inhibit cell migration through a novel, non-transcriptional HDAC6 pathway.
Kershaw S, Morgan DJ, Boyd J, Spiller DG, Kitchen G, Zindy E, Iqbal M, Rattray M, Sanderson CM, Brass A, Jorgensen C, Hussell T, Matthews LC, Ray DW
Journal of cell science 2020 Jun 11;133(11)
Journal of cell science 2020 Jun 11;133(11)
Δ9-tetrahydrocannabinol exposure during rat pregnancy leads to symmetrical fetal growth restriction and labyrinth-specific vascular defects in the placenta.
Natale BV, Gustin KN, Lee K, Holloway AC, Laviolette SR, Natale DRC, Hardy DB
Scientific reports 2020 Jan 17;10(1):544
Scientific reports 2020 Jan 17;10(1):544
MicroRNA 322 Aggravates Dexamethasone-Induced Muscle Atrophy by Targeting IGF1R and INSR.
Geng H, Song Q, Cheng Y, Li H, Yang R, Liu S, Hao L
International journal of molecular sciences 2020 Feb 7;21(3)
International journal of molecular sciences 2020 Feb 7;21(3)
The glucocorticoid receptor-FKBP51 complex contributes to fear conditioning and posttraumatic stress disorder.
Li H, Su P, Lai TK, Jiang A, Liu J, Zhai D, Campbell CT, Lee FH, Yong W, Pasricha S, Li S, Wong AH, Ressler KJ, Liu F
The Journal of clinical investigation 2020 Feb 3;130(2):877-889
The Journal of clinical investigation 2020 Feb 3;130(2):877-889
Hypoxia regulates GR function through multiple mechanisms involving microRNAs 103 and 107.
Yang N, Berry A, Sauer C, Baxter M, Donaldson IJ, Forbes K, Donn R, Matthews L, Ray D
Molecular and cellular endocrinology 2020 Dec 1;518:111007
Molecular and cellular endocrinology 2020 Dec 1;518:111007
Corticosterone Excess-Mediated Mitochondrial Damage Induces Hippocampal Neuronal Autophagy in Mice Following Cold Exposure.
Xu B, Lang L, Li S, Yuan J, Wang J, Yang H, Lian S
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Animals : an open access journal from MDPI 2019 Sep 14;9(9)
Developmental nicotine exposure elicits multigenerational disequilibria in proBDNF proteolysis and glucocorticoid signaling in the frontal cortices, striata, and hippocampi of adolescent mice.
Buck JM, O'Neill HC, Stitzel JA
Biochemical pharmacology 2019 Oct;168:438-451
Biochemical pharmacology 2019 Oct;168:438-451
Gestational stress induced differential expression of HDAC2 in male rat offspring hippocampus during development.
Liao L, Wang X, Yao X, Zhang B, Zhou L, Huang J
Neuroscience research 2019 Oct;147:9-16
Neuroscience research 2019 Oct;147:9-16
Cistromic Reprogramming of the Diurnal Glucocorticoid Hormone Response by High-Fat Diet.
Quagliarini F, Mir AA, Balazs K, Wierer M, Dyar KA, Jouffe C, Makris K, Hawe J, Heinig M, Filipp FV, Barish GD, Uhlenhaut NH
Molecular cell 2019 Nov 21;76(4):531-545.e5
Molecular cell 2019 Nov 21;76(4):531-545.e5
Response of the maternal hypothalamus to cold stress during late pregnancy in rats.
Wang D, Xu B, Wang J, Wang H, Guo J, Ji H, Li S, Wu R, Yang H, Lian S
Brain research 2019 Nov 1;1722:146354
Brain research 2019 Nov 1;1722:146354
An improved method for quantitative ChIP studies of nuclear receptor function.
Hunter AL, Narang N, Baxter M, Ray DW, Poolman TM
Journal of molecular endocrinology 2019 May 1;62(4):169-177
Journal of molecular endocrinology 2019 May 1;62(4):169-177
Sericin Nerve Guidance Conduit Delivering Therapeutically Repurposed Clobetasol for Functional and Structural Regeneration of Transected Peripheral Nerves.
Zhang L, Yang W, Xie H, Wang H, Wang J, Su Q, Li X, Song Y, Wang G, Wang L, Wang Z
ACS biomaterials science & engineering 2019 Mar 11;5(3):1426-1439
ACS biomaterials science & engineering 2019 Mar 11;5(3):1426-1439
Cortisol Excess-Mediated Mitochondrial Damage Induced Hippocampal Neuronal Apoptosis in Mice Following Cold Exposure.
Xu B, Lang LM, Li SZ, Guo JR, Wang JF, Wang D, Zhang LP, Yang HM, Lian S
Cells 2019 Jun 18;8(6)
Cells 2019 Jun 18;8(6)
E47 modulates hepatic glucocorticoid action.
Hemmer MC, Wierer M, Schachtrup K, Downes M, Hübner N, Evans RM, Uhlenhaut NH
Nature communications 2019 Jan 18;10(1):306
Nature communications 2019 Jan 18;10(1):306
Possible mechanisms of prenatal cold stress induced-anxiety-like behavior depression in offspring rats.
Lian S, Xu B, Wang D, Wang L, Li W, Yao R, Ji H, Wang J, Guo J, Li S, Yang H
Behavioural brain research 2019 Feb 1;359:304-311
Behavioural brain research 2019 Feb 1;359:304-311
Differences of physical vs. psychological stress: evidences from glucocorticoid receptor expression, hippocampal subfields injury, and behavioral abnormalities.
Li Y, Qin J, Yan J, Zhang N, Xu Y, Zhu Y, Sheng L, Zhu X, Ju S
Brain imaging and behavior 2019 Dec;13(6):1780-1788
Brain imaging and behavior 2019 Dec;13(6):1780-1788
REVERBa couples the circadian clock to hepatic glucocorticoid action.
Caratti G, Iqbal M, Hunter L, Kim D, Wang P, Vonslow RM, Begley N, Tetley AJ, Woodburn JL, Pariollaud M, Maidstone R, Donaldson IJ, Zhang Z, Ince LM, Kitchen G, Baxter M, Poolman TM, Daniels DA, Stirling DR, Brocker C, Gonzalez F, Loudon AS, Bechtold DA, Rattray M, Matthews LC, Ray DW
The Journal of clinical investigation 2018 Oct 1;128(10):4454-4471
The Journal of clinical investigation 2018 Oct 1;128(10):4454-4471
l-Arginine induces antioxidant response to prevent oxidative stress via stimulation of glutathione synthesis and activation of Nrf2 pathway.
Liang M, Wang Z, Li H, Cai L, Pan J, He H, Wu Q, Tang Y, Ma J, Yang L
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association 2018 May;115:315-328
α-Viniferin activates autophagic apoptosis and cell death by reducing glucocorticoid receptor expression in castration-resistant prostate cancer cells.
Cheng K, Liu X, Chen L, Lv JM, Qu FJ, Pan XW, Li L, Cui XG, Gao Y, Xu DF
Medical oncology (Northwood, London, England) 2018 Jun 15;35(7):105
Medical oncology (Northwood, London, England) 2018 Jun 15;35(7):105
Prenatal cold stress: Effect on maternal hippocampus and offspring behavior in rats.
Lian S, Wang D, Xu B, Guo W, Wang L, Li W, Ji H, Wang J, Kong F, Zhen L, Li S, Zhang L, Guo J, Yang H
Behavioural brain research 2018 Jul 2;346:1-10
Behavioural brain research 2018 Jul 2;346:1-10
Maternal betaine supplementation attenuates glucocorticoid-induced hepatic lipid accumulation through epigenetic modification in adult offspring rats.
Zhao N, Yang S, Jia Y, Sun B, He B, Zhao R
The Journal of nutritional biochemistry 2018 Apr;54:105-112
The Journal of nutritional biochemistry 2018 Apr;54:105-112
A non-transcriptional role for the glucocorticoid receptor in mediating the cell stress response.
Ptushkina M, Poolman T, Iqbal M, Ashe M, Petersen J, Woodburn J, Rattray M, Whetton A, Ray D
Scientific reports 2017 Sep 21;7(1):12101
Scientific reports 2017 Sep 21;7(1):12101
CUE domain-containing protein 2 promotes the Warburg effect and tumorigenesis.
Zhong X, Tian S, Zhang X, Diao X, Dong F, Yang J, Li Z, Sun L, Wang L, He X, Wu G, Hu X, Wang L, Song L, Zhang H, Pan X, Li A, Gao P
EMBO reports 2017 May;18(5):809-825
EMBO reports 2017 May;18(5):809-825
Glucocorticoid therapy regulates podocyte motility by inhibition of Rac1.
McCaffrey JC, Webb NJ, Poolman TM, Fresquet M, Moxey C, Zeef LAH, Donaldson IJ, Ray DW, Lennon R
Scientific reports 2017 Jul 27;7(1):6725
Scientific reports 2017 Jul 27;7(1):6725
Impact of prenatal cold stress on placental physiology, inflammatory response, and apoptosis in rats.
Lian S, Guo J, Wang L, Li W, Wang J, Ji H, Kong F, Xu B, Li S, Yang H
Oncotarget 2017 Dec 29;8(70):115304-115314
Oncotarget 2017 Dec 29;8(70):115304-115314
Long non-coding RNA GAS5 controls human embryonic stem cell self-renewal by maintaining NODAL signalling.
Xu C, Zhang Y, Wang Q, Xu Z, Jiang J, Gao Y, Gao M, Kang J, Wu M, Xiong J, Ji K, Yuan W, Wang Y, Liu H
Nature communications 2016 Nov 4;7:13287
Nature communications 2016 Nov 4;7:13287
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Scientific reports 2016 Mar 9;6:22831
Scientific reports 2016 Mar 9;6:22831
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Molecular medicine reports 2016 Jul;14(1):271-6
Molecular medicine reports 2016 Jul;14(1):271-6
The secretion, synthesis, and metabolism of cortisol and its downstream genes in the H-P-I axis of rare minnows (Gobiocypris rarus) are disrupted by acute waterborne cadmium exposure.
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Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2016 Jul-Aug;185-186:112-121
Comparative biochemistry and physiology. Toxicology & pharmacology : CBP 2016 Jul-Aug;185-186:112-121
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Proceedings of the National Academy of Sciences of the United States of America 2015 Apr 28;112(17):5479-84
Proceedings of the National Academy of Sciences of the United States of America 2015 Apr 28;112(17):5479-84
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PloS one 2013;8(6):e66876
PloS one 2013;8(6):e66876
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Nucleic acids research 2013 Oct;41(18):8515-25
Nucleic acids research 2013 Oct;41(18):8515-25
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Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- HeLa cells were subjected to SDS PAGE followed by western blot with 24050-1-AP(NR3C1 antibody) at dilution of 1:1000
- Sample type
- cell line
Supportive validation
- Submitted by
- Proteintech Group (provider)
- Main image
- Experimental details
- Immunofluorescent analysis of HepG2 cells, using NR3C1 antibody 24050-1-AP at 1:50 dilution and Rhodamine-labeled goat anti-rabbit IgG (red).
- Sample type
- cell line
