ABIN362461

antibody from antibodies-online

Targeting: MARCKS 80K-L, MACS, PKCSL

Western blot (Recommended by provider)

Immunohistochemistry (Recommended by provider)

Antibody Data

Product number

ABIN362461

Provider

antibodies-online

Product name

anti-Myristoylated Alanine-Rich Protein Kinase C Substrate (MARCKS) (pSer170) antibody

Antibody type

Polyclonal

Antigen

Peptide sequence around phosphorylation site of pSer170 (G-F-S (p) -F-K) derived from Human MARCKS. Antibodies were produced by immunizing rabbits with synthetic phosphopeptide and KLH conjugates.

Description

The antibody was affinity-purified from rabbit antiserum by affinity-chromatography usingepitope-specific phosphopeptide. The antibody against non-phosphopeptide was removedby chromatography using non-phosphopeptide corresponding to the phosphorylation site.

Reactivity

Human

Host

Rabbit

Epitope

pSer170

Isotype

IgG

Vial size

50 μL

Concentration

1 mg/mL

Storage

Store at -20°C for long term preservation (recommended). Store at 4°C for short term use.

References

Submitted references

MARCKS: a case of molecular exaptation?

Ramsden JJ
The international journal of biochemistry & cell biology 2000 May;32(5):475-9

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MARCKS is an actin filament crosslinking protein regulated by protein kinase C and calcium-calmodulin.

Hartwig JH, Thelen M, Rosen A, Janmey PA, Nairn AC, Aderem A
Nature 1992 Apr 16;356(6370):618-22

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Regulation by phosphorylation of reversible association of a myristoylated protein kinase C substrate with the plasma membrane.

Thelen M, Rosen A, Nairn AC, Aderem A
Nature 1991 May 23;351(6324):320-2

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Phosphorylation-regulated calmodulin binding to a prominent cellular substrate for protein kinase C.

Graff JM, Young TN, Johnson JD, Blackshear PJ
The Journal of biological chemistry 1989 Dec 25;264(36):21818-23