orb106884

antibody from Biorbyt
Targeting: H2AX H2AFX
Provider product page for orb106884
Western blot
Immunohistochemistry

Antibody data

Product number
orb106884 - Provider product page
Provider
Biorbyt
Product name
H2AFX antibody
Antibody type
Monoclonal
Antigen
Synthetic peptide
Description
Mouse monoclonal to H2AFX. Variant histone H2A which replaces conventional H2A in a subset of nucleosomes. Nucleosomes wrap and compact DNA into chromatin, limiting DNA accessibility to the cellular machineries which require DNA as a template. Histones thereby play a central role in transcription regulation, DNA repair, DNA replication and chromosomal stability. DNA accessibility is regulated via a complex set of post-translational modifications of histones, also called histone code, and nucleosome remodeling. Required for checkpoint-mediated arrest of cell cycle progression in response to low doses of ionizing radiation and for efficient repair of DNA double strand breaks (DSBs) specifically when modified by C-terminal phosphorylation.
Reactivity
Human
Host
Mouse
Conjugate
Unconjugated
Isotype
IgG
Antibody clone number
938CT5.1.1
Vial size
50 ul
Storage
Maintain refrigerated at 2-8°C for up to 2 weeks. For long term storage store at -20°C in small aliquots to prevent freeze-thaw cycles
H2AX protein structure - orb106884 shown in red.