Antibody data
- Antibody Data
- Antigen structure
- References [15]
- Comments [0]
- Validations
- Western blot [6]
- Immunocytochemistry [2]
- Immunohistochemistry [1]
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- Product number
- GTX127340 - Provider product page
- Provider
- GeneTex
- Product name
- Histone H2A.XS139ph (phospho Ser139) antibody
- Antibody type
- Polyclonal
- Reactivity
- Human, Mouse, Rat, Zebrafish
- Host
- Rabbit
Submitted references Pyruvate secreted from patient-derived cancer-associated fibroblasts supports survival of primary lymphoma cells.
SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program.
Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair.
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
3'-Hydroxy-4'-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells.
Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair.
αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells.
A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells.
Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine.
The direct interaction of NME3 with Tip60 in DNA repair.
Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response.
The contribution of CMP kinase to the efficiency of DNA repair.
Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.
Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance.
Sakamoto A, Kunou S, Shimada K, Tsunoda M, Aoki T, Iriyama C, Tomita A, Nakamura S, Hayakawa F, Kiyoi H
Cancer science 2019 Jan;110(1):269-278
Cancer science 2019 Jan;110(1):269-278
SRSF3 promotes pluripotency through Nanog mRNA export and coordination of the pluripotency gene expression program.
Ratnadiwakara M, Archer SK, Dent CI, Ruiz De Los Mozos I, Beilharz TH, Knaupp AS, Nefzger CM, Polo JM, Anko ML
eLife 2018 May 9;7
eLife 2018 May 9;7
Corylin increases the sensitivity of hepatocellular carcinoma cells to chemotherapy through long noncoding RNA RAD51-AS1-mediated inhibition of DNA repair.
Chen CC, Chen CY, Ueng SH, Hsueh C, Yeh CT, Ho JY, Chou LF, Wang TH
Cell death & disease 2018 May 1;9(5):543
Cell death & disease 2018 May 1;9(5):543
Tissue-selective effects of nucleolar stress and rDNA damage in developmental disorders.
Calo E, Gu B, Bowen ME, Aryan F, Zalc A, Liang J, Flynn RA, Swigut T, Chang HY, Attardi LD, Wysocka J
Nature 2018 Feb 1;554(7690):112-117
Nature 2018 Feb 1;554(7690):112-117
The anticancer effects of MPT0G211, a novel HDAC6 inhibitor, combined with chemotherapeutic agents in human acute leukemia cells.
Tu HJ, Lin YJ, Chao MW, Sung TY, Wu YW, Chen YY, Lin MH, Liou JP, Pan SL, Yang CR
Clinical epigenetics 2018 Dec 29;10(1):162
Clinical epigenetics 2018 Dec 29;10(1):162
3'-Hydroxy-4'-methoxy-β-methyl-β-nitrostyrene inhibits tumor growth through ROS generation and GSH depletion in lung cancer cells.
Tsai CH, Hsieh PW, Lee YC, Wang CH, Chiu WC, Lu CW, Wang YY, Hu SC, Cheng TL, Yuan SF
Life sciences 2017 Mar 1;172:19-26
Life sciences 2017 Mar 1;172:19-26
Nuclear TRADD prevents DNA damage-mediated death by facilitating non-homologous end-joining repair.
Koo GB, Ji JH, Cho H, Morgan MJ, Kim YS
Scientific reports 2017 Jun 13;7(1):3332
Scientific reports 2017 Jun 13;7(1):3332
αTAT1 downregulation induces mitotic catastrophe in HeLa and A549 cells.
Chien JY, Tsen SD, Chien CC, Liu HW, Tung CY, Lin CH
Cell death discovery 2016;2:16006
Cell death discovery 2016;2:16006
A microtubule inhibitor, ABT-751, induces autophagy and delays apoptosis in Huh-7 cells.
Wei RJ, Lin SS, Wu WR, Chen LR, Li CF, Chen HD, Chou CT, Chen YC, Liang SS, Chien ST, Shiue YL
Toxicology and applied pharmacology 2016 Nov 15;311:88-98
Toxicology and applied pharmacology 2016 Nov 15;311:88-98
Systematic discovery of drug action mechanisms by an integrated chemical genomics approach: identification of functional disparities between azacytidine and decitabine.
Hsieh YY, Huang TC, Lo HL, Jhan JY, Chen ST, Yang PM
Oncotarget 2016 May 10;7(19):27363-78
Oncotarget 2016 May 10;7(19):27363-78
The direct interaction of NME3 with Tip60 in DNA repair.
Tsao N, Yang YC, Deng YJ, Chang ZF
The Biochemical journal 2016 May 1;473(9):1237-45
The Biochemical journal 2016 May 1;473(9):1237-45
Topoisomerase II Inhibitors Can Enhance Baculovirus-Mediated Gene Expression in Mammalian Cells through the DNA Damage Response.
Liu MK, Lin JJ, Chen CY, Kuo SC, Wang YM, Chan HL, Wu TY
International journal of molecular sciences 2016 Jun 14;17(6)
International journal of molecular sciences 2016 Jun 14;17(6)
The contribution of CMP kinase to the efficiency of DNA repair.
Tsao N, Lee MH, Zhang W, Cheng YC, Chang ZF
Cell cycle (Georgetown, Tex.) 2015;14(3):354-63
Cell cycle (Georgetown, Tex.) 2015;14(3):354-63
Variations in dysfunction of sister chromatid cohesion in esco2 mutant zebrafish reflect the phenotypic diversity of Roberts syndrome.
Percival SM, Thomas HR, Amsterdam A, Carroll AJ, Lees JA, Yost HJ, Parant JM
Disease models & mechanisms 2015 Aug 1;8(8):941-55
Disease models & mechanisms 2015 Aug 1;8(8):941-55
Identification of up- and down-regulated proteins in doxorubicin-resistant uterine cancer cells: reticulocalbin-1 plays a key role in the development of doxorubicin-associated resistance.
May EW, Lin ST, Lin CC, Chang JF, Hung E, Lo YW, Lin LH, Hu RY, Feng CL, Lin DY, Wu SB, Lee WC, Lyu KW, Chou HC, Chan HL
Pharmacological research 2014 Dec;90:1-17
Pharmacological research 2014 Dec;90:1-17
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Supportive validation
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- Experimental details
- Histone H2A.X (phospho Ser139) antibody detects H2AFX protein by western blot analysis.A. 30 ?g HCT116 whole cell lysate/extract (untreated for 2hr)B. 30 ?g HCT116 whole cell lysate/extract (UVB treatment 50mJ for 2hr)C. 30 ?g HCT116 whole cell lysate/extract (untreated for 6hr)D. 30 ?g HCT116 whole cell lysate/extract (UVB treatment 50mJ for 6hr)15% SDS-PAGEHistone H2A.X (phospho Ser139) antibody (GTX127340) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
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- Sample (30 ?g of whole cell lysate) A: HCT116 control 0 hr B: HCT116 treated with 30 ?M cisplatin for 24 hr 12% SDS PAGE GTX127340 diluted at 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Histone H2A.X (phospho Ser139) antibody detects H2AFX protein in cisplatin-treated samples by western blot analysis.A. 30 ?g NIH-3T3 whole cell lysate/extract (untreated) B. 30 ?g NIH-3T3 whole cell lysate/extract (30?M cisplatin treatment for 24hr)15% SDS-PAGEHistone H2A.X (phospho Ser139) antibody (GTX127340) dilution: 1:1000 The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Histone H2A.XS139ph (phospho Ser139) antibody detects Histone H2A.XS139ph (phospho Ser139) protein by western blot analysis. Un-treated (-) and treated (+, 30 ?M cisplatin treatment for 24 hrs) PC-12 whole cell extracts (30 ?g) were separated by 15% SDS-PAGE, and the membrane was blotted with Histone H2A.XS139ph (phospho Ser139) antibody (GTX127340) diluted at 1:500. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Untreated (¡V) and treated (+) HCT-116 whole cell extract (30 ?g) were separated by 15% SDS-PAGE, and the membrane was blotted with Histone H2A.XS139ph (phospho Ser139) antibody (GTX127340) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Untreated (¡V) and treated (+) HCT-116 whole cell extract (30 ?g) were separated by 15% SDS-PAGE, and the membrane was blotted with Histone H2A.XS139ph (phospho Ser139) antibody (GTX127340) diluted at 1:1000. The HRP-conjugated anti-rabbit IgG antibody (GTX213110-01) was used to detect the primary antibody.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Histone H2A.X (phospho Ser139) antibody detects H2AFX protein at nuclear by confocal immunofluorescent analysis. Sample: 10uM Cisplatin treated (right) or untreated (left) HeLa cells were fixed in 4% paraformaldehyde for 15 min. Green: H2AFX protein stained by Histone H2A.X (phospho Ser139) antibody (GTX127340) diluted at 1:1000. Blue: Hoechst 33342 staining. Scale bar = 10 £gm. [Images captured by Olympus FV10i Confocal Laser Scanning Microscope]
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Histone H2A.XS139ph (phospho Ser139) antibody detects Histone H2A.XS139ph (phospho Ser139) protein at nucleus by immunofluorescent analysis. Samples: HeLa cells mock (left) and treated with 30 £gM Cisplatin for 24 hrs (right) were fixed in 4% paraformaldehyde at RT for 15 min.Green: Histone H2A.XS139ph (phospho Ser139) protein stained by Histone H2A.XS139ph (phospho Ser139) antibody (GTX127340) diluted at 1:1000.Blue: Hoechst 33342 staining.Scale bar = 10 £gm.
Supportive validation
- Submitted by
- GeneTex (provider)
- Main image
- Experimental details
- Histone H2A.XS139ph (phospho Ser139) antibody detects Histone H2A.XS139ph (phospho Ser139) protein at nucleus on human ovarian carcinoma by immunohistochemical analysis. Sample: Paraffin-embedded human ovarian carcinoma. Histone H2A.XS139ph (phospho Ser139) antibody (GTX127340) diluted at 1:250.