Explore
Validate
Learn
ImmunohistochemistryAntibody data
- Antibody Data
- Antigen structure
- References [8]
- Comments [0]
- Validations [0]
Submit
Validation data
Reference
Comment
Report error
- Product number
- ABIN966245 - Provider product page
- Provider
- antibodies-online
- Product name
- anti-H2A Histone Family, Member X (H2AFX) (C-Term) antibody
- Antibody type
- Polyclonal
- Antigen
- Polyclonal antibody produced in rabbits immunizing with a synthetic peptide corresponding to Cterminal residues of human H2AFX (Histone H2A.x )
- Reactivity
- Human
- Vial size
- 0.1mg
Submitted references Mdc1 couples DNA double-strand break recognition by Nbs1 with its H2AX-dependent chromatin retention.
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.
Megabase chromatin domains involved in DNA double-strand breaks in vivo.
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
Lukas C, Melander F, Stucki M, Falck J, Bekker-Jensen S, Goldberg M, Lerenthal Y, Jackson SP, Bartek J, Lukas J
The EMBO journal 2004 Jul 7;23(13):2674-83
The EMBO journal 2004 Jul 7;23(13):2674-83
ATM and DNA-PK function redundantly to phosphorylate H2AX after exposure to ionizing radiation.
Stiff T, O'Driscoll M, Rief N, Iwabuchi K, Löbrich M, Jeggo PA
Cancer research 2004 Apr 1;64(7):2390-6
Cancer research 2004 Apr 1;64(7):2390-6
Phosphorylation of histone H2AX and activation of Mre11, Rad50, and Nbs1 in response to replication-dependent DNA double-strand breaks induced by mammalian DNA topoisomerase I cleavage complexes.
Furuta T, Takemura H, Liao ZY, Aune GJ, Redon C, Sedelnikova OA, Pilch DR, Rogakou EP, Celeste A, Chen HT, Nussenzweig A, Aladjem MI, Bonner WM, Pommier Y
The Journal of biological chemistry 2003 May 30;278(22):20303-12
The Journal of biological chemistry 2003 May 30;278(22):20303-12
Accumulation of checkpoint protein 53BP1 at DNA breaks involves its binding to phosphorylated histone H2AX.
Ward IM, Minn K, Jorda KG, Chen J
The Journal of biological chemistry 2003 May 30;278(22):19579-82
The Journal of biological chemistry 2003 May 30;278(22):19579-82
MDC1 is a mediator of the mammalian DNA damage checkpoint.
Stewart GS, Wang B, Bignell CR, Taylor AM, Elledge SJ
Nature 2003 Feb 27;421(6926):961-6
Nature 2003 Feb 27;421(6926):961-6
Histone H2AX is phosphorylated in an ATR-dependent manner in response to replicational stress.
Ward IM, Chen J
The Journal of biological chemistry 2001 Dec 21;276(51):47759-62
The Journal of biological chemistry 2001 Dec 21;276(51):47759-62
Megabase chromatin domains involved in DNA double-strand breaks in vivo.
Rogakou EP, Boon C, Redon C, Bonner WM
The Journal of cell biology 1999 Sep 6;146(5):905-16
The Journal of cell biology 1999 Sep 6;146(5):905-16
DNA double-stranded breaks induce histone H2AX phosphorylation on serine 139.
Rogakou EP, Pilch DR, Orr AH, Ivanova VS, Bonner WM
The Journal of biological chemistry 1998 Mar 6;273(10):5858-68
The Journal of biological chemistry 1998 Mar 6;273(10):5858-68
No comments: Submit comment
No validations: Submit validation data