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Western blotAntibody data
- Antibody Data
- Antigen structure
- References [735]
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- Validations
- Western blot [1]
- Immunocytochemistry [2]
- Other assay [9]
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- Product number
- AM4300 - Provider product page
- Provider
- Invitrogen Antibodies
- Product name
- GAPDH Monoclonal Antibody (6C5)
- Antibody type
- Monoclonal
- Antigen
- Purifed from natural sources
- Reactivity
- Human, Mouse, Rat, Canine, Chicken/Avian, Rabbit
- Host
- Mouse
- Isotype
- IgG
- Antibody clone number
- 6C5
- Vial size
- 100 µg
- Storage
- Maintain refrigerated at 2-8°C for up to 1 month. For long term storage store at -20°C
Submitted references Study on Toll-Like Receptor 2-Mediated Inflammation-Induced Familial Hypertension Combined with Hyperlipemia and Its Mechanism.
Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids.
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.
MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells.
The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.
Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma.
TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Deep learning for de-convolution of Smad2 versus Smad3 binding sites.
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.
Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma.
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.
MYC amplifies gene expression through global changes in transcription factor dynamics.
GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors.
High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals.
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.
Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia.
Histone deacetylase HDAC2 regulates microRNA-125a expression in neuroblastoma.
The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.
PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II.
Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.
Induction of osteogenesis by bone-targeted Notch activation.
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.
Pten regulates collagen fibrillogenesis by fibroblasts through SPARC.
Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88.
Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.
Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis.
Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling.
Loss of presenilin function enhances tau phosphorylation and aggregation in mice.
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.
A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function.
Zbtb46-dependent altered developmental program in embryonic stem cell-derived blood cell progenitors.
Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation.
Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT.
P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation.
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA.
The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling.
A cytosolic reductase pathway is required for efficient N-glycosylation of an STT3B-dependent acceptor site.
Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level.
Effect of Microbial Status on Hepatic Odd-Chain Fatty Acids Is Diet-Dependent.
Pericentromeric Satellite III transcripts induce etoposide resistance.
microRNAs (miR 9, 124, 155 and 224) transdifferentiate mouse macrophages to neurons.
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.
A lamin A/C variant causing striated muscle disease provides insights into filament organization.
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis.
AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS.
TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers.
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Integrin α4β1 is required for IL-1α- and Nrf2-dependent, Cox-2 induction in fibroblasts, supporting a mechanism that suppresses α-SMA expression.
Targeting senescent cells improves functional recovery after spinal cord injury.
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis.
Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts.
Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells.
An epilepsy-associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model.
Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles.
Expanding the clinical and metabolic phenotype of DPM2 deficient congenital disorders of glycosylation.
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes.
The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.
MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration.
Bisphenol A promotes stress granule assembly and modulates the integrated stress response.
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.
Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.
Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein.
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.
Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells.
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer.
AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
Human Cytomegalovirus UL138 Protein Inhibits the STING Pathway and Reduces Interferon Beta mRNA Accumulation during Lytic and Latent Infections.
High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats.
Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.
Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells.
Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase.
A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.
The exocyst complex regulates C. elegans germline stem cell proliferation by controlling membrane Notch levels.
Liquid-like protein interactions catalyse assembly of endocytic vesicles.
Restricted Water Intake Adversely Affects Rat Vocal Fold Biology.
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Drosophila primary microRNA-8 encodes a microRNA-encoded peptide acting in parallel of miR-8.
Inhibitory Activity of Boesenbergia rotunda (L.) Mansf. Rhizome towards the Expression of Akt and NF-KappaB p65 in Acetic Acid-Induced Wistar Rats.
Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells.
Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice.
Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished T(H)17 but Enhanced T(reg) Differentiation.
Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line.
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression.
The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.
MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells.
Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating.
Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.
G(4)C(2) Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Antiviral Properties of the LSD1 Inhibitor SP-2509.
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.
Systemic Delivery of AAV-Fdxr Mitigates the Phenotypes of Mitochondrial Disorders in Fdxr Mutant Mice.
Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.
Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development.
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Neuropilin-1 is up-regulated by cancer-associated fibroblast-secreted IL-8 and associated with cell proliferation of gallbladder cancer.
Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.
Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling.
Dissecting the transactivation domain (tAD) of the transcription factor c-Myb to assess recent models of tAD function.
The absence of (TCAGGG)(n) repeats in some telomeres, combined with variable responses to NR2F2 depletion, suggest that this nuclear receptor plays an indirect role in the alternative lengthening of telomeres.
Connexin43 Region 266-283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
Phosphorylation of Ykt6 SNARE Domain Regulates Its Membrane Recruitment and Activity.
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.
Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.
Different training intensities induced autophagy and histopathology appearances potentially associated with lipid metabolism in wistar rat liver.
A transcriptional roadmap for 2C-like-to-pluripotent state transition.
Human THO maintains the stability of repetitive DNA.
Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction.
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2).
Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.
Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment.
Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD.
A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation.
Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores.
Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.
Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation.
Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.
Abl-mediated PI3K activation regulates macrophage podosome formation.
Alternative polyadenylation mediates genetic regulation of gene expression.
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Rab27a Contributes to the Processing of Inflammatory Pain in Mice.
Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.
The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism.
Wnt/β-catenin-activated Ewing sarcoma cells promote the angiogenic switch.
Sex-specific features of spine densities in the hippocampus.
Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation.
Osmotic gradients induce stable dome morphogenesis on extracellular matrix.
The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors.
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma.
The role of polo-like kinase 3 in the response of BRAF-mutant cells to targeted anticancer therapies.
Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.
An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21.
miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model.
Bim contributes to the progression of Huntington's disease-associated phenotypes.
AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53.
Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.
Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.
Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway.
Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43(266-283).
Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
Low Dose of β-Carotene Regulates Inflammation, Reduces Caspase Signaling, and Correlates with Autophagy Activation in Cardiomyoblast Cell Lines.
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2.
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development.
The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties.
Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling.
Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment.
Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium.
miR-125 family regulates XIRP1 and FIH in response to myocardial infarction.
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Recombinant human ADAMTS13 treatment and anti-NET strategies enhance skin allograft survival in mice.
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.
Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity.
Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.
Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.
Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.
Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.
Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.
Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats.
TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death.
Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells.
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements.
A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy.
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors.
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.
Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis.
PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process.
Dorsal convergence of gastrula cells requires Vangl2 and an adhesion protein-dependent change in protrusive activity.
Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions.
LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.
Role of Ryanodine Type 2 Receptors in Elementary Ca(2+) Signaling in Arteries and Vascular Adaptive Responses.
A protein quality control pathway regulated by linear ubiquitination.
LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.
Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells.
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.
Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet.
Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.
The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.
Alteration of Autophagy Gene Expression by Different Intensity of Exercise in Gastrocnemius and Soleus Muscles of Wistar Rats.
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells.
Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells.
Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.
GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice.
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling.
p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.
The priming factor CAPS1 regulates dense-core vesicle acidification by interacting with rabconnectin3β/WDR7 in neuroendocrine cells.
Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.
Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells.
Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells.
Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.
Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.
Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation.
Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.
E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity.
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.
Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice.
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet.
Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974.
Autophagosome immunoisolation from GFP-LC3B mouse tissue.
Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity.
Developmental Xist induction is mediated by enhanced splicing.
Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy.
Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production.
Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice.
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions.
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice.
A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling.
Stimulated upregulation of HO-1 is associated with inadequate response of gastric and ovarian cancer cell lines to hyperthermia and cisplatin treatment.
HDAC3 and HDAC8 are required for cilia assembly and elongation.
Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.
Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response.
Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice.
ERp18 regulates activation of ATF6α during unfolded protein response.
Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice.
Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma.
A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.
Glucocorticoid-Induced Autophagy Protects Osteocytes Against Oxidative Stress Through Activation of MAPK/ERK Signaling.
m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia.
Modeling Glycan Processing Reveals Golgi-Enzyme Homeostasis upon Trafficking Defects and Cellular Differentiation.
High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.
Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione.
Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity.
Nutmeg Extract Increases Skeletal Muscle Mass in Aging Rats Partly via IGF1-AKT-mTOR Pathway and Inhibition of Autophagy.
Murine macrophage TLR2-FcγR synergy via FcγR licensing of IL-6 cytokine mRNA ribosome binding and translation.
Host-directed combinatorial RNAi improves inhibition of diverse strains of influenza A virus in human respiratory epithelial cells.
CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.
Decreased Hippocampal Neuroplasticity and Behavioral Impairment in an Animal Model of Inhalant Abuse.
Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival.
Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino-1.
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.
β(2)-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC.
The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.
Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers.
Cancer exosomes induce tumor innervation.
Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice.
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.
Low temperature decreases bone mass in mice: Implications for humans.
The α(2)δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α(2)δ-1.
Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea.
Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain.
Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix.
KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner.
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.
Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells.
Modulation of glutathione promotes apoptosis in triple-negative breast cancer cells.
Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.
Dimerization of the cellular prion protein inhibits propagation of scrapie prions.
Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.
Caspase-mediated cleavage of the centrosomal proteins during apoptosis.
Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy.
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
A homozygous variant disrupting the PIGH start-codon is associated with developmental delay, epilepsy, and microcephaly.
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.
The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E-transformed cells.
Mouse medulloblastoma driven by CRISPR activation of cellular Myc.
The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac Ca(V)1.2 calcium channels.
The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation.
Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.
Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.
The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine.
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.
The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.
Notch1 is asymmetrically distributed from the beginning of embryogenesis and controls the ventral center.
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction.
Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.
RAPGEF5 Regulates Nuclear Translocation of β-Catenin.
The protein kinase SIK downregulates the polarity protein Par3.
Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes.
Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.
Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis.
Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo.
Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.
Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development.
Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.
A novel probe to assess cytosolic entry of exogenous proteins.
Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model.
MicroRNA miR-509 Regulates ERK1/2, the Vimentin Network, and Focal Adhesions by Targeting Plk1.
Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression.
Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.
p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells.
Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Elongator subunit 3 (ELP3) modifies ALS through tRNA modification.
Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response.
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.
Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity.
FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression.
The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules.
Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.
Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice.
Cardiac troponin T and fast skeletal muscle denervation in ageing.
Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.
Data-Modeling Identifies Conflicting Signaling Axes Governing Myoblast Proliferation and Differentiation Responses to Diverse Ligand Stimuli.
Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.
VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction.
Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1-42) synaptotoxicity.
A Detailed Protocol for Subcellular RNA Sequencing (subRNA-seq).
Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.
Histone isoform H2A1H promotes attainment of distinct physiological states by altering chromatin dynamics.
Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.
Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy.
cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition.
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.
Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells.
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.
Nanoparticulate titanium dioxide-inhibited dendritic development is involved in apoptosis and autophagy of hippocampal neurons in offspring mice.
Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.
P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.
Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma.
A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter.
Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.
Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA.
Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes.
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
Proteasome Activation by Small Molecules.
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.
PLK4 phosphorylation of CP110 is required for efficient centriole assembly.
Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells.
Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation.
A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.
MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production.
Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes.
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment.
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice.
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.
Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.
Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide.
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.
AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice.
Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools.
A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.
Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3.
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.
Gα(11) mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.
Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala.
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue.
Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.
Pervasive translational regulation of the cell signalling circuitry underlies mammalian development.
Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus.
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.
Modulation of BCR Signaling by the Induced Dimerization of Receptor-Associated SYK.
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.
RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis.
The neuroprotective agent Rasagiline mesylate attenuates cardiac remodeling after experimental myocardial infarction.
Overexpression of Thioredoxin1 enhances functional recovery in a mouse model of hind limb ischemia.
Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection.
A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.
The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
Accumulation of autophagosomes confers cytotoxicity.
The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores.
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.
Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease.
The Retromer Supports AMPA Receptor Trafficking During LTP.
Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.
Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.
Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition.
Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.
Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice.
Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.
Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.
Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1.
The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns.
Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.
Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction.
Cellular effects induced by 17-β-estradiol to reduce the survival of renal cell carcinoma cells.
Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
Sp1 downregulates proinflammatory cytokine‑induced catabolic gene expression in nucleus pulposus cells.
Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.
Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread.
Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency.
Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.
Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.
Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle.
Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.
Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.
PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status.
Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay.
A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer.
A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.
TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.
Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours.
Novel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells.
SREBP2 Activation Induces Hepatic Long-chain Acyl-CoA Synthetase 1 (ACSL1) Expression in Vivo and in Vitro through a Sterol Regulatory Element (SRE) Motif of the ACSL1 C-promoter.
Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.
FNDC5 is produced in the stomach and associated to body composition.
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.
Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice.
Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures.
Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.
Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells.
Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage.
An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron.
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation.
Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.
Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer.
The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration.
Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis.
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.
Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity.
Tbc1d1 deletion suppresses obesity in leptin-deficient mice.
Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism.
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.
PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Diacylglycerol pyrophosphate binds and inhibits the glyceraldehyde-3-phosphate dehydrogenase in barley aleurone.
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices.
Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection.
RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.
Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.
Shigella infection interferes with SUMOylation and increases PML-NB number.
Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.
Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma.
Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.
TRIM29 regulates the p63-mediated pathway in cervical cancer cells.
A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation.
Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.
Antigen-B Cell Receptor Complexes Associate with Intracellular major histocompatibility complex (MHC) Class II Molecules.
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.
Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus.
MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling.
Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum.
Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome.
Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury.
CD200: association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.
The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus.
Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses.
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.
Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.
A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.
Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity.
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.
Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells.
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation.
Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity.
Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.
Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.
Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle.
Calcitriol ameliorates renal damage in a pre-established proteinuria model.
Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.
Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
Analysis of human papillomavirus E7 protein status in C-33A cervical cancer cells.
GAPDH and β-actin protein decreases with aging, making Stain-Free technology a superior loading control in Western blotting of human skeletal muscle.
FOXG1 expression shows correlation with neuronal differentiation in cerebellar development, aggressive phenotype in medulloblastomas, and survival in a xenograft model of medulloblastoma.
Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.
S100A8, An Oocyte-Specific Chemokine, Directs the Migration of Ovarian Somatic Cells During Mouse Primordial Follicle Assembly.
PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit.
Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E.
Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen.
CRISPR/Cas9: An inexpensive, efficient loss of function tool to screen human disease genes in Xenopus.
MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.
Functional Analysis of the 60-Nucleotide Duplication in the Respiratory Syncytial Virus Buenos Aires Strain Attachment Glycoprotein.
Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.
An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.
Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.
A Dual SILAC Proteomic Labeling Strategy for Quantifying Constitutive and Cell-Cell Induced Protein Secretion.
Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.
Turning terminally differentiated skeletal muscle cells into regenerative progenitors.
Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.
Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.
An analysis of critical factors for quantitative immunoblotting.
Mitochondrial DNA stress primes the antiviral innate immune response.
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.
Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.
CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies.
PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomes.
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.
Serum stability and physicochemical characterization of a novel amphipathic peptide C6M1 for siRNA delivery.
Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.
Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S).
Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells.
L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction.
Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype.
Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm.
Overexpression of aquaporin 1 in the tunica vaginalis may contribute to adult-onset primary hydrocele testis.
CD137 enhancement of HPV positive head and neck squamous cell carcinoma tumor clearance.
Ras-mediated deregulation of the circadian clock in cancer.
IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis.
Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms.
A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.
Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice.
Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.
Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse.
Human placental transcriptome shows sexually dimorphic gene expression and responsiveness to maternal dietary n-3 long-chain polyunsaturated fatty acid intervention during pregnancy.
SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.
Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Cisplatin plus sodium arsenite and hyperthermia induces pseudo-G1 associated apoptotic cell death in ovarian cancer cells.
Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice.
Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition.
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis.
Detection of WIPI1 mRNA as an indicator of autophagosome formation.
LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.
Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines.
Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.
PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1.
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells.
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.
A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury.
Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.
Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?
Steroidogenic factor 1 promotes aggressive growth of castration-resistant prostate cancer cells by stimulating steroid synthesis and cell proliferation.
Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.
St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb.
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA.
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD.
microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.
Increased serum and musculotendinous fibrogenic proteins following persistent low-grade inflammation in a rat model of long-term upper extremity overuse.
Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal.
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.
Polychlorinated biphenyls impair dibutyryl cAMP-induced astrocytic differentiation in rat C6 glial cell line.
Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication.
Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain.
Interaction of PICK1 with C-terminus of growth hormone-releasing hormone receptor (GHRHR) modulates trafficking and signal transduction of human GHRHR.
Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells.
Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury.
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
Tumor protein D52 represents a negative regulator of ATM protein levels.
Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.
RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins.
Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.
Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.
Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.
Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface.
Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.
Mitochondrial DNA (mtDNA) in brain samples from patients with major psychiatric disorders: gene expression profiles, mtDNA content and presence of the mtDNA common deletion.
N-cadherin expression is regulated by UTP in schwannoma cells.
Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells.
Surface proteins of C6/36 cells involved in dengue virus 4 binding and entry.
α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.
Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways.
Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2.
Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.
Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress.
SnoN/SKIL modulates proliferation through control of hsa-miR-720 transcription in esophageal cancer cells.
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9.
Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.
Differential glial activation during the degeneration of Purkinje cells and mitral cells in the PCD mutant mice.
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis.
Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.
c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells.
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.
Histone h1 depletion impairs embryonic stem cell differentiation.
Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice.
Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming.
Human ALKBH4 interacts with proteins associated with transcription.
Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity.
A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma.
Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice.
The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.
Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.
Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts.
The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.
Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.
Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages.
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).
Abnormal platelet aggregation in idiopathic pulmonary arterial hypertension: role of nitric oxide.
Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions.
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells.
MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop.
Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
Mouse germ cell clusters form by aggregation as well as clonal divisions.
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages.
Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss.
Profiling of linker histone variants in ovarian cancer.
GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
Nestin expression is lost in ventricular fibroblasts during postnatal development of the rat heart and re-expressed in scar myofibroblasts.
Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.
AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells.
Reduced connexin43 expression correlates with c-Src activation, proliferation, and glucose uptake in reactive astrocytes after an excitotoxic insult.
The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.
Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice.
Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells.
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
NMDA mediated contextual conditioning changes miRNA expression.
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue.
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress.
Cyclin D1 inhibits mitochondrial activity in B cells.
Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression.
Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer.
Development of an Fn14 agonistic antibody as an anti-tumor agent.
KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma.
The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.
Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite.
Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation.
Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.
Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis.
Loss of VOPP1 overexpression in squamous carcinoma cells induces apoptosis through oxidative cellular injury.
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.
A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis.
Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.
Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells.
Comparison of two dimensional electrophoresis mouse colon proteomes before and after knocking out Aquaporin 8.
Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase.
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression.
Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing.
Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway.
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase.
Parkin is protective against proteotoxic stress in a transgenic zebrafish model.
Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.
Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations.
MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation.
Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules.
Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo.
Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.
Cross talk between microRNA and epigenetic regulation in adult neurogenesis.
Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development.
Intracellular signaling pathways control mitochondrial events associated with the development of ischemia/ reperfusion-associated damage.
C. elegans ATAD-3 is essential for mitochondrial activity and development.
Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway.
Everolimus attenuates neointimal hyperplasia in cultured human saphenous vein grafts.
Molecular cloning and characterization of the common marmoset huntingtin gene.
Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Binding of Silurus asotus lectin to Gb3 on Raji cells causes disappearance of membrane-bound form of HSP70.
Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies.
Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain.
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.
Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.
Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts.
Molecular mechanism underlying differential apoptosis between human melanoma cell lines UACC903 and UACC903(+6) revealed by mitochondria-focused cDNA microarrays.
Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets.
Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria.
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
BMP suppresses PTEN expression via RAS/ERK signaling.
Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies.
LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.
Liu J, Li C, Wang Q, Hu H, Li C, Qian J
Journal of healthcare engineering 2022;2022:1473597
Journal of healthcare engineering 2022;2022:1473597
Downregulation of low-density lipoprotein receptor mRNA in lymphatic endothelial cells impairs lymphatic function through changes in intracellular lipids.
Vachon L, Smaani A, Tessier N, Jean G, Demers A, Milasan A, Ardo N, Jarry S, Villeneuve L, Alikashani A, Finherty V, Ruiz M, Sorci-Thomas MG, Mayer G, Martel C
Theranostics 2022;12(3):1440-1458
Theranostics 2022;12(3):1440-1458
Hepatocytes Deficient in Nuclear Envelope Protein Lamina-associated Polypeptide 1 are an Ideal Mammalian System to Study Intranuclear Lipid Droplets.
Östlund C, Hernandez-Ono A, Turk SJ, Dauer WT, Ginsberg HN, Worman HJ, Shin JY
Journal of lipid research 2022 Oct;63(10):100277
Journal of lipid research 2022 Oct;63(10):100277
MiR-146b-5p regulates IL-23 receptor complex expression in chronic lymphocytic leukemia cells.
Matis S, Grazia Recchia A, Colombo M, Cardillo M, Fabbi M, Todoerti K, Bossio S, Fabris S, Cancila V, Massara R, Reverberi D, Emionite L, Cilli M, Cerruti G, Salvi S, Bet P, Pigozzi S, Fiocca R, Ibatici A, Angelucci E, Gentile M, Monti P, Menichini P, Fronza G, Torricelli F, Ciarrocchi A, Neri A, Fais F, Tripodo C, Morabito F, Ferrarini M, Cutrona G
Blood advances 2022 Oct 25;6(20):5593-5612
Blood advances 2022 Oct 25;6(20):5593-5612
The caspase-6-p62 axis modulates p62 droplets based autophagy in a dominant-negative manner.
Valionyte E, Yang Y, Griffiths SA, Bone AT, Barrow ER, Sharma V, Lu B, Luo S
Cell death and differentiation 2022 Jun;29(6):1211-1227
Cell death and differentiation 2022 Jun;29(6):1211-1227
Ets1 mediates sorafenib resistance by regulating mitochondrial ROS pathway in hepatocellular carcinoma.
Vishnoi K, Ke R, Viswakarma N, Srivastava P, Kumar S, Das S, Singh SK, Principe DR, Rana A, Rana B
Cell death & disease 2022 Jul 4;13(7):581
Cell death & disease 2022 Jul 4;13(7):581
TRIM7 Restricts Coxsackievirus and Norovirus Infection by Detecting the C-Terminal Glutamine Generated by 3C Protease Processing.
Luptak J, Mallery DL, Jahun AS, Albecka A, Clift D, Ather O, Slodkowicz G, Goodfellow I, James LC
Viruses 2022 Jul 23;14(8)
Viruses 2022 Jul 23;14(8)
Deep learning for de-convolution of Smad2 versus Smad3 binding sites.
Ng JWK, Ong EHQ, Tucker-Kellogg L, Tucker-Kellogg G
BMC genomics 2022 Jul 20;23(Suppl 1):525
BMC genomics 2022 Jul 20;23(Suppl 1):525
Oncogenic BRAF induces whole-genome doubling through suppression of cytokinesis.
Darp R, Vittoria MA, Ganem NJ, Ceol CJ
Nature communications 2022 Jul 15;13(1):4109
Nature communications 2022 Jul 15;13(1):4109
Phyllanthus taxodiifolius Beille Disrupted N-cadherin, Vimentin, Paxillin and Actin Stress Fibers in Glioblastoma.
Sunrat C, Kwanthongdee J, Uppakara K, Chabang N, Munyoo B, Tuchinda P, Saengsawang W
Asian Pacific journal of cancer prevention : APJCP 2022 Jul 1;23(7):2379-2386
Asian Pacific journal of cancer prevention : APJCP 2022 Jul 1;23(7):2379-2386
Aberrant stromal tissue factor localisation and mycolactone-driven vascular dysfunction, exacerbated by IL-1β, are linked to fibrin formation in Buruli ulcer lesions.
Hsieh LT, Dos Santos SJ, Hall BS, Ogbechi J, Loglo AD, Salguero FJ, Ruf MT, Pluschke G, Simmonds RE
PLoS pathogens 2022 Jan;18(1):e1010280
PLoS pathogens 2022 Jan;18(1):e1010280
MYC amplifies gene expression through global changes in transcription factor dynamics.
Patange S, Ball DA, Wan Y, Karpova TS, Girvan M, Levens D, Larson DR
Cell reports 2022 Jan 25;38(4):110292
Cell reports 2022 Jan 25;38(4):110292
GS-CA1 and lenacapavir stabilize the HIV-1 core and modulate the core interaction with cellular factors.
Selyutina A, Hu P, Miller S, Simons LM, Yu HJ, Hultquist JF, Lee K, KewalRamani VN, Diaz-Griffero F
iScience 2022 Jan 21;25(1):103593
iScience 2022 Jan 21;25(1):103593
High-titer neutralization of Mu and C.1.2 SARS-CoV-2 variants by vaccine-elicited antibodies of previously infected individuals.
Tada T, Zhou H, Dcosta BM, Samanovic MI, Cornelius A, Herati RS, Mulligan MJ, Landau NR
Cell reports 2022 Jan 11;38(2):110237
Cell reports 2022 Jan 11;38(2):110237
Alteration of ribosome function upon 5-fluorouracil treatment favors cancer cell drug-tolerance.
Therizols G, Bash-Imam Z, Panthu B, Machon C, Vincent A, Ripoll J, Nait-Slimane S, Chalabi-Dchar M, Gaucherot A, Garcia M, Laforêts F, Marcel V, Boubaker-Vitre J, Monet MA, Bouclier C, Vanbelle C, Souahlia G, Berthel E, Albaret MA, Mertani HC, Prudhomme M, Bertrand M, David A, Saurin JC, Bouvet P, Rivals E, Ohlmann T, Guitton J, Dalla Venezia N, Pannequin J, Catez F, Diaz JJ
Nature communications 2022 Jan 10;13(1):173
Nature communications 2022 Jan 10;13(1):173
Genome-wide CRISPR screen identifies regulators of MAPK and MTOR pathways mediating sorafenib resistance in acute myeloid leukemia.
Damnernsawad A, Bottomly D, Kurtz SE, Eide CA, McWeeney SK, Tyner JW, Nechiporuk T
Haematologica 2022 Jan 1;107(1):77-85
Haematologica 2022 Jan 1;107(1):77-85
Histone deacetylase HDAC2 regulates microRNA-125a expression in neuroblastoma.
Liu D, Tang X, Huang Z, Wen J, Zhou Y
Brain and behavior 2022 Feb;12(2):e2401
Brain and behavior 2022 Feb;12(2):e2401
The Purkinje-myocardial junction is the anatomic origin of ventricular arrhythmia in CPVT.
Blackwell DJ, Faggioni M, Wleklinski MJ, Gomez-Hurtado N, Venkataraman R, Gibbs CE, Baudenbacher FJ, Gong S, Fishman GI, Boyle PM, Pfeifer K, Knollmann BC
JCI insight 2022 Feb 8;7(3)
JCI insight 2022 Feb 8;7(3)
PD-L1 promotes myofibroblastic activation of hepatic stellate cells by distinct mechanisms selective for TGF-β receptor I versus II.
Sun L, Wang Y, Wang X, Navarro-Corcuera A, Ilyas S, Jalan-Sakrikar N, Gan C, Tu X, Shi Y, Tu K, Liu Q, Lou Z, Dong H, Sharpe AH, Shah VH, Kang N
Cell reports 2022 Feb 8;38(6):110349
Cell reports 2022 Feb 8;38(6):110349
Multiple 9-1-1 complexes promote homolog synapsis, DSB repair, and ATR signaling during mammalian meiosis.
Pereira C, Arroyo-Martinez GA, Guo MZ, Downey MS, Kelly ER, Grive KJ, Mahadevaiah SK, Sims JR, Faca VM, Tsai C, Schiltz CJ, Wit N, Jacobs H, Clark NL, Freire R, Turner J, Lyndaker AM, Brieno-Enriquez MA, Cohen PE, Smolka MB, Weiss RS
eLife 2022 Feb 8;11
eLife 2022 Feb 8;11
Induction of osteogenesis by bone-targeted Notch activation.
Xu C, Dinh VV, Kruse K, Jeong HW, Watson EC, Adams S, Berkenfeld F, Stehling M, Rasouli SJ, Fan R, Chen R, Bedzhov I, Chen Q, Kato K, Pitulescu ME, Adams RH
eLife 2022 Feb 4;11
eLife 2022 Feb 4;11
Ras-mutant cancers are sensitive to small molecule inhibition of V-type ATPases in mice.
Tolani B, Celli A, Yao Y, Tan YZ, Fetter R, Liem CR, de Smith AJ, Vasanthakumar T, Bisignano P, Cotton AD, Seiple IB, Rubinstein JL, Jost M, Weissman JS
Nature biotechnology 2022 Dec;40(12):1834-1844
Nature biotechnology 2022 Dec;40(12):1834-1844
Interspecies Differences in Proteome Turnover Kinetics Are Correlated With Life Spans and Energetic Demands.
Swovick K, Firsanov D, Welle KA, Hryhorenko JR, Wise JP Sr, George C, Sformo TL, Seluanov A, Gorbunova V, Ghaemmaghami S
Molecular & cellular proteomics : MCP 2021;20:100041
Molecular & cellular proteomics : MCP 2021;20:100041
Pten regulates collagen fibrillogenesis by fibroblasts through SPARC.
Jones CE, Sharick JT, Colbert SE, Shukla VC, Zent JM, Ostrowski MC, Ghadiali SN, Sizemore ST, Leight JL
PloS one 2021;16(2):e0245653
PloS one 2021;16(2):e0245653
Renoprotective Effects of Maslinic Acid on Experimental Renal Fibrosis in Unilateral Ureteral Obstruction Model via Targeting MyD88.
Sun W, Byon CH, Kim DH, Choi HI, Park JS, Joo SY, Kim IJ, Jung I, Bae EH, Ma SK, Kim SW
Frontiers in pharmacology 2021;12:708575
Frontiers in pharmacology 2021;12:708575
Circ_CLASP2 Regulates High Glucose-Induced Dysfunction of Human Endothelial Cells Through Targeting miR-140-5p/FBXW7 Axis.
Zhang Q, Long J, Li N, Ma X, Zheng L
Frontiers in pharmacology 2021;12:594793
Frontiers in pharmacology 2021;12:594793
Macrophages Demonstrate Guanylate-Binding Protein-Dependent and Bacterial Strain-Dependent Responses to Francisella tularensis.
Mohammadi N, Lindgren H, Yamamoto M, Martin A, Henry T, Sjöstedt A
Frontiers in cellular and infection microbiology 2021;11:784101
Frontiers in cellular and infection microbiology 2021;11:784101
Promotion of Bone Lesions Through the Myeloma Integrin α6-Mediated Osteolytic Signaling.
Liu H, Wang Z, He J, Li Z, Gao JY, Liu R, Lin P, Yang J
Frontiers in oncology 2021;11:692190
Frontiers in oncology 2021;11:692190
Loss of presenilin function enhances tau phosphorylation and aggregation in mice.
Soto-Faguás CM, Sanchez-Molina P, Saura CA
Acta neuropathologica communications 2021 Sep 30;9(1):162
Acta neuropathologica communications 2021 Sep 30;9(1):162
TNF-α synergises with IFN-γ to induce caspase-8-JAK1/2-STAT1-dependent death of intestinal epithelial cells.
Woznicki JA, Saini N, Flood P, Rajaram S, Lee CM, Stamou P, Skowyra A, Bustamante-Garrido M, Regazzoni K, Crawford N, McDade SS, Longley DB, Aza-Blanc P, Shanahan F, Zulquernain SA, McCarthy J, Melgar S, McRae BL, Nally K
Cell death & disease 2021 Sep 23;12(10):864
Cell death & disease 2021 Sep 23;12(10):864
DNA methylation is required to maintain both DNA replication timing precision and 3D genome organization integrity.
Du Q, Smith GC, Luu PL, Ferguson JM, Armstrong NJ, Caldon CE, Campbell EM, Nair SS, Zotenko E, Gould CM, Buckley M, Chia KM, Portman N, Lim E, Kaczorowski D, Chan CL, Barton K, Deveson IW, Smith MA, Powell JE, Skvortsova K, Stirzaker C, Achinger-Kawecka J, Clark SJ
Cell reports 2021 Sep 21;36(12):109722
Cell reports 2021 Sep 21;36(12):109722
A general role for TANGO1, encoded by MIA3, in secretory pathway organization and function.
McCaughey J, Stevenson NL, Mantell JM, Neal CR, Paterson A, Heesom K, Stephens DJ
Journal of cell science 2021 Sep 1;134(17)
Journal of cell science 2021 Sep 1;134(17)
Zbtb46-dependent altered developmental program in embryonic stem cell-derived blood cell progenitors.
Boto P, Gerzsenyi TB, Lengyel A, Szunyog B, Szatmari I
Stem cells (Dayton, Ohio) 2021 Oct;39(10):1322-1334
Stem cells (Dayton, Ohio) 2021 Oct;39(10):1322-1334
Evidence That a TRPA1-Mediated Murine Model of Temporomandibular Joint Pain Involves NLRP3 Inflammasome Activation.
Kodji X, Kee Z, McKenna R, de Sousa Valente J, Ravenscroft H, McMillan H, Gamble J, Dombrowski Y, Moynagh P, Brough D, Lundy FT, Brain SD, El Karim IA
Pharmaceuticals (Basel, Switzerland) 2021 Oct 23;14(11)
Pharmaceuticals (Basel, Switzerland) 2021 Oct 23;14(11)
Proteotoxic Stress as an Exploitable Vulnerability in Cells with Hyperactive AKT.
Babagana M, Brown LR, Slabodkin HZ, Kichina JV, Kandel ES
International journal of molecular sciences 2021 Oct 21;22(21)
International journal of molecular sciences 2021 Oct 21;22(21)
P-selectin targeted RAGE-shRNA lipoplexes alleviate atherosclerosis-associated inflammation.
Mocanu CA, Fuior EV, Voicu G, Rebleanu D, Safciuc F, Deleanu M, Fenyo IM, Escriou V, Manduteanu I, Simionescu M, Calin M
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:754-772
Journal of controlled release : official journal of the Controlled Release Society 2021 Oct 10;338:754-772
Identification of novel lipid droplet factors that regulate lipophagy and cholesterol efflux in macrophage foam cells.
Robichaud S, Fairman G, Vijithakumar V, Mak E, Cook DP, Pelletier AR, Huard S, Vanderhyden BC, Figeys D, Lavallée-Adam M, Baetz K, Ouimet M
Autophagy 2021 Nov;17(11):3671-3689
Autophagy 2021 Nov;17(11):3671-3689
Multiplexed Simian Immunodeficiency Virus-Specific Paired RNA-Guided Cas9 Nickases Inactivate Proviral DNA.
Smith LM, Ladner JT, Hodara VL, Parodi LM, Harris RA, Callery JE, Lai Z, Zou Y, Raveedran M, Rogers J, Giavedoni LD
Journal of virology 2021 Nov 9;95(23):e0088221
Journal of virology 2021 Nov 9;95(23):e0088221
The K63 deubiquitinase CYLD modulates autism-like behaviors and hippocampal plasticity by regulating autophagy and mTOR signaling.
Colombo E, Horta G, Roesler MK, Ihbe N, Chhabra S, Radyushkin K, Di Liberto G, Kreutzfeldt M, Schumann S, von Engelhardt J, Merkler D, Behl C, Mittmann T, Clement AM, Waisman A, Schmeisser MJ
Proceedings of the National Academy of Sciences of the United States of America 2021 Nov 23;118(47)
Proceedings of the National Academy of Sciences of the United States of America 2021 Nov 23;118(47)
A cytosolic reductase pathway is required for efficient N-glycosylation of an STT3B-dependent acceptor site.
van Lith M, Pringle MA, Fleming B, Gaeta G, Im J, Gilmore R, Bulleid NJ
Journal of cell science 2021 Nov 15;134(22)
Journal of cell science 2021 Nov 15;134(22)
Image-based high-throughput mapping of TGF-β-induced phosphocomplexes at a single-cell level.
Lönn P, Al-Amin RA, Doulabi EM, Heldin J, Gallini R, Björkesten J, Oelrich J, Kamali-Moghaddam M, Landegren U
Communications biology 2021 Nov 12;4(1):1284
Communications biology 2021 Nov 12;4(1):1284
Effect of Microbial Status on Hepatic Odd-Chain Fatty Acids Is Diet-Dependent.
Weitkunat K, Bishop CA, Wittmüss M, Machate T, Schifelbein T, Schulze MB, Klaus S
Nutrients 2021 May 4;13(5)
Nutrients 2021 May 4;13(5)
Pericentromeric Satellite III transcripts induce etoposide resistance.
Kanne J, Hussong M, Isensee J, Muñoz-López Á, Wolffgramm J, Heß F, Grimm C, Bessonov S, Meder L, Wang J, Reinhardt HC, Odenthal M, Hucho T, Büttner R, Summerer D, Schweiger MR
Cell death & disease 2021 May 24;12(6):530
Cell death & disease 2021 May 24;12(6):530
microRNAs (miR 9, 124, 155 and 224) transdifferentiate mouse macrophages to neurons.
Challagundla N, Agrawal-Rajput R
Experimental cell research 2021 May 1;402(1):112563
Experimental cell research 2021 May 1;402(1):112563
MED15 prion-like domain forms a coiled-coil responsible for its amyloid conversion and propagation.
Batlle C, Calvo I, Iglesias V, J Lynch C, Gil-Garcia M, Serrano M, Ventura S
Communications biology 2021 Mar 26;4(1):414
Communications biology 2021 Mar 26;4(1):414
A lamin A/C variant causing striated muscle disease provides insights into filament organization.
Kronenberg-Tenga R, Tatli M, Eibauer M, Wu W, Shin JY, Bonne G, Worman HJ, Medalia O
Journal of cell science 2021 Mar 22;134(6)
Journal of cell science 2021 Mar 22;134(6)
Mitochondria-rough-ER contacts in the liver regulate systemic lipid homeostasis.
Anastasia I, Ilacqua N, Raimondi A, Lemieux P, Ghandehari-Alavijeh R, Faure G, Mekhedov SL, Williams KJ, Caicci F, Valle G, Giacomello M, Quiroga AD, Lehner R, Miksis MJ, Toth K, de Aguiar Vallim TQ, Koonin EV, Scorrano L, Pellegrini L
Cell reports 2021 Mar 16;34(11):108873
Cell reports 2021 Mar 16;34(11):108873
AAV9-mediated gene delivery of MCT1 to oligodendrocytes does not provide a therapeutic benefit in a mouse model of ALS.
Eykens C, Rossaert E, Duqué S, Rué L, Bento-Abreu A, Hersmus N, Lenaerts A, Kerstens A, Corthout N, Munck S, Van Damme P, Holt MG, von Jonquires G, Klugmann M, Van Den Bosch L, Robberecht W
Molecular therapy. Methods & clinical development 2021 Mar 12;20:508-519
Molecular therapy. Methods & clinical development 2021 Mar 12;20:508-519
TGF-β-dependent reprogramming of amino acid metabolism induces epithelial-mesenchymal transition in non-small cell lung cancers.
Nakasuka F, Tabata S, Sakamoto T, Hirayama A, Ebi H, Yamada T, Umetsu K, Ohishi M, Ueno A, Goto H, Sugimoto M, Nishioka Y, Yamada Y, Tomita M, Sasaki AT, Yano S, Soga T
Communications biology 2021 Jun 24;4(1):782
Communications biology 2021 Jun 24;4(1):782
RGS10 physically and functionally interacts with STIM2 and requires store-operated calcium entry to regulate pro-inflammatory gene expression in microglia.
Wendimu MY, Alqinyah M, Vella S, Dean P, Almutairi F, Davila-Rivera R, Rayatpisheh S, Wohlschlegel J, Moreno S, Hooks SB
Cellular signalling 2021 Jul;83:109974
Cellular signalling 2021 Jul;83:109974
Integrin α4β1 is required for IL-1α- and Nrf2-dependent, Cox-2 induction in fibroblasts, supporting a mechanism that suppresses α-SMA expression.
Zheng R, Varney SD, Wu L, DiPersio CM, Van De Water L
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2021 Jul;29(4):597-601
Wound repair and regeneration : official publication of the Wound Healing Society [and] the European Tissue Repair Society 2021 Jul;29(4):597-601
Targeting senescent cells improves functional recovery after spinal cord injury.
Paramos-de-Carvalho D, Martins I, Cristóvão AM, Dias AF, Neves-Silva D, Pereira T, Chapela D, Farinho A, Jacinto A, Saúde L
Cell reports 2021 Jul 6;36(1):109334
Cell reports 2021 Jul 6;36(1):109334
GIMAP5 maintains liver endothelial cell homeostasis and prevents portal hypertension.
Drzewiecki K, Choi J, Brancale J, Leney-Greene MA, Sari S, Dalgiç B, Ünlüsoy Aksu A, Evirgen Şahin G, Ozen A, Baris S, Karakoc-Aydiner E, Jain D, Kleiner D, Schmalz M, Radhakrishnan K, Zhang J, Hoebe K, Su HC, Pereira JP, Lenardo MJ, Lifton RP, Vilarinho S
The Journal of experimental medicine 2021 Jul 5;218(7)
The Journal of experimental medicine 2021 Jul 5;218(7)
Protein farnesylation is upregulated in Alzheimer's human brains and neuron-specific suppression of farnesyltransferase mitigates pathogenic processes in Alzheimer's model mice.
Jeong A, Cheng S, Zhong R, Bennett DA, Bergö MO, Li L
Acta neuropathologica communications 2021 Jul 27;9(1):129
Acta neuropathologica communications 2021 Jul 27;9(1):129
Inhibition of the canonical Wnt signaling pathway by a β-catenin/CBP inhibitor prevents heart failure by ameliorating cardiac hypertrophy and fibrosis.
Methatham T, Tomida S, Kimura N, Imai Y, Aizawa K
Scientific reports 2021 Jul 21;11(1):14886
Scientific reports 2021 Jul 21;11(1):14886
Loss of Tsc1 in cerebellar Purkinje cells induces transcriptional and translation changes in FMRP target transcripts.
Dalal JS, Winden KD, Salussolia CL, Sundberg M, Singh A, Pham TT, Zhou P, Pu WT, Miller MT, Sahin M
eLife 2021 Jul 14;10
eLife 2021 Jul 14;10
Targeting microRNA-mediated gene repression limits adipogenic conversion of skeletal muscle mesenchymal stromal cells.
Wosczyna MN, Perez Carbajal EE, Wagner MW, Paredes S, Konishi CT, Liu L, Wang TT, Walsh RA, Gan Q, Morrissey CS, Rando TA
Cell stem cell 2021 Jul 1;28(7):1323-1334.e8
Cell stem cell 2021 Jul 1;28(7):1323-1334.e8
An epilepsy-associated ACTL6B variant captures neuronal hyperexcitability in a human induced pluripotent stem cell model.
Ahn LY, Coatti GC, Liu J, Gumus E, Schaffer AE, Miranda HC
Journal of neuroscience research 2021 Jan;99(1):110-123
Journal of neuroscience research 2021 Jan;99(1):110-123
Force dependent effects of chronic overuse on fibrosis-related genes and proteins in skeletal muscles.
Hilliard BA, Amin M, Popoff SN, Barbe MF
Connective tissue research 2021 Jan;62(1):133-149
Connective tissue research 2021 Jan;62(1):133-149
Expanding the clinical and metabolic phenotype of DPM2 deficient congenital disorders of glycosylation.
Radenkovic S, Fitzpatrick-Schmidt T, Byeon SK, Madugundu AK, Saraswat M, Lichty A, Wong SYW, McGee S, Kubiak K, Ligezka A, Ranatunga W, Zhang Y, Wood T, Friez MJ, Clarkson K, Pandey A, Jones JR, Morava E
Molecular genetics and metabolism 2021 Jan;132(1):27-37
Molecular genetics and metabolism 2021 Jan;132(1):27-37
Acetyl-CoA Synthetase 2: A Critical Linkage in Obesity-Induced Tumorigenesis in Myeloma.
Li Z, Liu H, He J, Wang Z, Yin Z, You G, Wang Z, Davis RE, Lin P, Bergsagel PL, Manasanch EE, Wong STC, Esnaola NF, Chang JC, Orlowski RZ, Yi Q, Yang J
Cell metabolism 2021 Jan 5;33(1):78-93.e7
Cell metabolism 2021 Jan 5;33(1):78-93.e7
Identification of a dynamic gene regulatory network required for pluripotency factor-induced reprogramming of mouse fibroblasts and hepatocytes.
Papathanasiou M, Tsiftsoglou SA, Polyzos AP, Papadopoulou D, Valakos D, Klagkou E, Karagianni P, Pliatska M, Talianidis I, Agelopoulos M, Thanos D
The EMBO journal 2021 Jan 4;40(1):e102236
The EMBO journal 2021 Jan 4;40(1):e102236
The cytoskeleton actin binding protein filamin A impairs both IGF2 mitogenic effects and the efficacy of IGF1R inhibitors in adrenocortical cancer cells.
Catalano R, Giardino E, Treppiedi D, Mangili F, Morelli V, Elli FM, Serban AL, Luconi M, Mannelli M, Spada A, Arosio M, Mantovani G, Peverelli E
Cancer letters 2021 Jan 28;497:77-88
Cancer letters 2021 Jan 28;497:77-88
MCT1 Deletion in Oligodendrocyte Lineage Cells Causes Late-Onset Hypomyelination and Axonal Degeneration.
Philips T, Mironova YA, Jouroukhin Y, Chew J, Vidensky S, Farah MH, Pletnikov MV, Bergles DE, Morrison BM, Rothstein JD
Cell reports 2021 Jan 12;34(2):108610
Cell reports 2021 Jan 12;34(2):108610
Bisphenol A promotes stress granule assembly and modulates the integrated stress response.
Fay MM, Columbo D, Cotter C, Friend C, Henry S, Hoppe M, Karabelas P, Lamy C, Lawell M, Monteith S, Noyes C, Salerno P, Wu J, Zhang HM, Anderson PJ, Kedersha N, Ivanov P, Farny NG
Biology open 2021 Jan 10;10(1)
Biology open 2021 Jan 10;10(1)
Neutrophils interact with cholangiocytes to cause cholestatic changes in alcoholic hepatitis.
Takeuchi M, Vidigal PT, Guerra MT, Hundt MA, Robert ME, Olave-Martinez M, Aoki S, Khamphaya T, Kersten R, Kruglov E, de la Rosa Rodriguez R, Banales JM, Nathanson MH, Weerachayaphorn J
Gut 2021 Feb;70(2):342-356
Gut 2021 Feb;70(2):342-356
Catechol-O-methyltransferase and Pregnancy Outcome: an Appraisal in Rat.
Iqbal K, Dhakal P, Pierce SH, Soares MJ
Reproductive sciences (Thousand Oaks, Calif.) 2021 Feb;28(2):462-469
Reproductive sciences (Thousand Oaks, Calif.) 2021 Feb;28(2):462-469
Human Hematopoietic Stem, Progenitor, and Immune Cells Respond Ex Vivo to SARS-CoV-2 Spike Protein.
Ropa J, Cooper S, Capitano ML, Van't Hof W, Broxmeyer HE
Stem cell reviews and reports 2021 Feb;17(1):253-265
Stem cell reviews and reports 2021 Feb;17(1):253-265
The G127V variant of the prion protein interferes with dimer formation in vitro but not in cellulo.
Sangeetham SB, Engelke AD, Fodor E, Krausz SL, Tatzelt J, Welker E
Scientific reports 2021 Feb 4;11(1):3116
Scientific reports 2021 Feb 4;11(1):3116
Tryptophan Metabolism Regulates Proliferative Capacity of Human Pluripotent Stem Cells.
Someya S, Tohyama S, Kameda K, Tanosaki S, Morita Y, Sasaki K, Kang MI, Kishino Y, Okada M, Tani H, Soma Y, Nakajima K, Umei T, Sekine O, Moriwaki T, Kanazawa H, Kobayashi E, Fujita J, Fukuda K
iScience 2021 Feb 19;24(2):102090
iScience 2021 Feb 19;24(2):102090
BRG1 knockdown inhibits proliferation through multiple cellular pathways in prostate cancer.
Giles KA, Gould CM, Achinger-Kawecka J, Page SG, Kafer GR, Rogers S, Luu PL, Cesare AJ, Clark SJ, Taberlay PC
Clinical epigenetics 2021 Feb 17;13(1):37
Clinical epigenetics 2021 Feb 17;13(1):37
AXL Is a Potential Target for the Treatment of Intestinal Fibrosis.
Steiner CA, Rodansky ES, Johnson LA, Berinstein JA, Cushing KC, Huang S, Spence JR, Higgins PDR
Inflammatory bowel diseases 2021 Feb 16;27(3):303-316
Inflammatory bowel diseases 2021 Feb 16;27(3):303-316
Human Cytomegalovirus UL138 Protein Inhibits the STING Pathway and Reduces Interferon Beta mRNA Accumulation during Lytic and Latent Infections.
Albright ER, Mickelson CK, Kalejta RF
mBio 2021 Dec 21;12(6):e0226721
mBio 2021 Dec 21;12(6):e0226721
High Caloric Diet Induces Memory Impairment and Disrupts Synaptic Plasticity in Aged Rats.
Paulo SL, Miranda-Lourenço C, Belo RF, Rodrigues RS, Fonseca-Gomes J, Tanqueiro SR, Geraldes V, Rocha I, Sebastião AM, Xapelli S, Diógenes MJ
Current issues in molecular biology 2021 Dec 18;43(3):2305-2319
Current issues in molecular biology 2021 Dec 18;43(3):2305-2319
Generation and analysis of innovative genomically humanized knockin SOD1, TARDBP (TDP-43), and FUS mouse models.
Devoy A, Price G, De Giorgio F, Bunton-Stasyshyn R, Thompson D, Gasco S, Allan A, Codner GF, Nair RR, Tibbit C, McLeod R, Ali Z, Noda J, Marrero-Gagliardi A, Brito-Armas JM, Williams C, Öztürk MM, Simon M, O'Neill E, Bryce-Smith S, Harrison J, Atkins G, Corrochano S, Stewart M, Gilthorpe JD, Teboul L, Acevedo-Arozena A, Fisher EMC, Cunningham TJ
iScience 2021 Dec 17;24(12):103463
iScience 2021 Dec 17;24(12):103463
Efficient generation of osteoclasts from human induced pluripotent stem cells and functional investigations of lethal CLCN7-related osteopetrosis.
Rössler U, Hennig AF, Stelzer N, Bose S, Kopp J, Søe K, Cyganek L, Zifarelli G, Ali S, von der Hagen M, Strässler ET, Hahn G, Pusch M, Stauber T, Izsvák Z, Gossen M, Stachelscheid H, Kornak U
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 Aug;36(8):1621-1635
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2021 Aug;36(8):1621-1635
Curcumin induces apoptosis by inhibiting BCAT1 expression and mTOR signaling in cytarabine‑resistant myeloid leukemia cells.
Tseng YH, Yang RC, Chiou SS, Shieh TM, Shih YH, Lin PC
Molecular medicine reports 2021 Aug;24(2)
Molecular medicine reports 2021 Aug;24(2)
Triple deletion of TP53, PCNT, and CEP215 promotes centriole amplification in the M phase.
Jung GI, Rhee K
Cell cycle (Georgetown, Tex.) 2021 Aug;20(15):1500-1517
Cell cycle (Georgetown, Tex.) 2021 Aug;20(15):1500-1517
A recombinant herpes virus expressing influenza hemagglutinin confers protection and induces antibody-dependent cellular cytotoxicity.
Kaugars K, Dardick J, de Oliveira AP, Weiss KA, Lukose R, Kim J, Leung L, Rajagopalan S, Wolin S, Akabas L, Knipe DM, Bajic G, Jacobs WR Jr
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 24;118(34)
Proceedings of the National Academy of Sciences of the United States of America 2021 Aug 24;118(34)
The exocyst complex regulates C. elegans germline stem cell proliferation by controlling membrane Notch levels.
Pushpa K, Dagar S, Kumar H, Pathak D, Mylavarapu SVS
Development (Cambridge, England) 2021 Aug 1;148(15)
Development (Cambridge, England) 2021 Aug 1;148(15)
Liquid-like protein interactions catalyse assembly of endocytic vesicles.
Day KJ, Kago G, Wang L, Richter JB, Hayden CC, Lafer EM, Stachowiak JC
Nature cell biology 2021 Apr;23(4):366-376
Nature cell biology 2021 Apr;23(4):366-376
Restricted Water Intake Adversely Affects Rat Vocal Fold Biology.
Duan C, do Nascimento NC, Calve S, Cox A, Sivasankar MP
The Laryngoscope 2021 Apr;131(4):839-845
The Laryngoscope 2021 Apr;131(4):839-845
Glioblastomas acquire myeloid-affiliated transcriptional programs via epigenetic immunoediting to elicit immune evasion.
Gangoso E, Southgate B, Bradley L, Rus S, Galvez-Cancino F, McGivern N, Güç E, Kapourani CA, Byron A, Ferguson KM, Alfazema N, Morrison G, Grant V, Blin C, Sou I, Marques-Torrejon MA, Conde L, Parrinello S, Herrero J, Beck S, Brandner S, Brennan PM, Bertone P, Pollard JW, Quezada SA, Sproul D, Frame MC, Serrels A, Pollard SM
Cell 2021 Apr 29;184(9):2454-2470.e26
Cell 2021 Apr 29;184(9):2454-2470.e26
Drosophila primary microRNA-8 encodes a microRNA-encoded peptide acting in parallel of miR-8.
Montigny A, Tavormina P, Duboe C, San Clémente H, Aguilar M, Valenti P, Lauressergues D, Combier JP, Plaza S
Genome biology 2021 Apr 23;22(1):118
Genome biology 2021 Apr 23;22(1):118
Inhibitory Activity of Boesenbergia rotunda (L.) Mansf. Rhizome towards the Expression of Akt and NF-KappaB p65 in Acetic Acid-Induced Wistar Rats.
Rosdianto AM, Puspitasari IM, Lesmana R, Levita J
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6940313
Evidence-based complementary and alternative medicine : eCAM 2020;2020:6940313
Autophagy Upregulation by the TFEB Inducer Trehalose Protects against Oxidative Damage and Cell Death Associated with NRF2 Inhibition in Human RPE Cells.
Abokyi S, Shan SW, To CH, Chan HH, Tse DY
Oxidative medicine and cellular longevity 2020;2020:5296341
Oxidative medicine and cellular longevity 2020;2020:5296341
Mitochondrial Dysfunction Is an Early Consequence of Partial or Complete Dystrophin Loss in mdx Mice.
Moore TM, Lin AJ, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Nguyen CQ, Yackly A, Mahata SK, Wanagat J, Stiles L, Turcotte LP, Crosbie RH, Zhou Z
Frontiers in physiology 2020;11:690
Frontiers in physiology 2020;11:690
Piperlongumine Acts as an Immunosuppressant by Exerting Prooxidative Effects in Human T Cells Resulting in Diminished T(H)17 but Enhanced T(reg) Differentiation.
Liang J, Ziegler JD, Jahraus B, Orlik C, Blatnik R, Blank N, Niesler B, Wabnitz G, Ruppert T, Hübner K, Balta E, Samstag Y
Frontiers in immunology 2020;11:1172
Frontiers in immunology 2020;11:1172
Chicken avian β-defensin 8 modulates immune response via the mitogen-activated protein kinase signaling pathways in a chicken macrophage cell line.
Hong Y, Lee J, Vu TH, Lee S, Lillehoj HS, Hong YH
Poultry science 2020 Sep;99(9):4174-4182
Poultry science 2020 Sep;99(9):4174-4182
Increased nuclear factor I/B expression in prostate cancer correlates with AR expression.
Nanda JS, Awadallah WN, Kohrt SE, Popovics P, Cates JMM, Mirosevich J, Clark PE, Giannico GA, Grabowska MM
The Prostate 2020 Sep;80(13):1058-1070
The Prostate 2020 Sep;80(13):1058-1070
The SUMO Conjugase Ubc9 Protects Dopaminergic Cells from Cytotoxicity and Enhances the Stability of α-Synuclein in Parkinson's Disease Models.
Verma DK, Ghosh A, Ruggiero L, Cartier E, Janezic E, Williams D, Jung EG, Moore M, Seo JB, Kim YH
eNeuro 2020 Sep Oct;7(5)
eNeuro 2020 Sep Oct;7(5)
MicroRNA-19a-PTEN Axis Is Involved in the Developmental Decline of Axon Regenerative Capacity in Retinal Ganglion Cells.
Mak HK, Yung JSY, Weinreb RN, Ng SH, Cao X, Ho TYC, Ng TK, Chu WK, Yung WH, Choy KW, Wang CC, Lee TL, Leung CK
Molecular therapy. Nucleic acids 2020 Sep 4;21:251-263
Molecular therapy. Nucleic acids 2020 Sep 4;21:251-263
Nuclear Import of the HIV-1 Core Precedes Reverse Transcription and Uncoating.
Selyutina A, Persaud M, Lee K, KewalRamani V, Diaz-Griffero F
Cell reports 2020 Sep 29;32(13):108201
Cell reports 2020 Sep 29;32(13):108201
Light-regulated allosteric switch enables temporal and subcellular control of enzyme activity.
Shaaya M, Fauser J, Zhurikhina A, Conage-Pough JE, Huyot V, Brennan M, Flower CT, Matsche J, Khan S, Natarajan V, Rehman J, Kota P, White FM, Tsygankov D, Karginov AV
eLife 2020 Sep 23;9
eLife 2020 Sep 23;9
G(4)C(2) Repeat RNA Initiates a POM121-Mediated Reduction in Specific Nucleoporins in C9orf72 ALS/FTD.
Coyne AN, Zaepfel BL, Hayes L, Fitchman B, Salzberg Y, Luo EC, Bowen K, Trost H, Aigner S, Rigo F, Yeo GW, Harel A, Svendsen CN, Sareen D, Rothstein JD
Neuron 2020 Sep 23;107(6):1124-1140.e11
Neuron 2020 Sep 23;107(6):1124-1140.e11
Antiviral Properties of the LSD1 Inhibitor SP-2509.
Harancher MR, Packard JE, Cowan SP, DeLuca NA, Dembowski JA
Journal of virology 2020 Sep 15;94(19)
Journal of virology 2020 Sep 15;94(19)
Mechanism and inhibition of the papain-like protease, PLpro, of SARS-CoV-2.
Klemm T, Ebert G, Calleja DJ, Allison CC, Richardson LW, Bernardini JP, Lu BG, Kuchel NW, Grohmann C, Shibata Y, Gan ZY, Cooney JP, Doerflinger M, Au AE, Blackmore TR, van der Heden van Noort GJ, Geurink PP, Ovaa H, Newman J, Riboldi-Tunnicliffe A, Czabotar PE, Mitchell JP, Feltham R, Lechtenberg BC, Lowes KN, Dewson G, Pellegrini M, Lessene G, Komander D
The EMBO journal 2020 Sep 15;39(18):e106275
The EMBO journal 2020 Sep 15;39(18):e106275
The GSK-3β-FBXL21 Axis Contributes to Circadian TCAP Degradation and Skeletal Muscle Function.
Wirianto M, Yang J, Kim E, Gao S, Paudel KR, Choi JM, Choe J, Gloston GF, Ademoji P, Parakramaweera R, Jin J, Esser KA, Jung SY, Geng YJ, Lee HK, Chen Z, Yoo SH
Cell reports 2020 Sep 15;32(11):108140
Cell reports 2020 Sep 15;32(11):108140
Systemic Delivery of AAV-Fdxr Mitigates the Phenotypes of Mitochondrial Disorders in Fdxr Mutant Mice.
Yang L, Slone J, Zou W, Queme LF, Jankowski MP, Yin F, Huang T
Molecular therapy. Methods & clinical development 2020 Sep 11;18:84-97
Molecular therapy. Methods & clinical development 2020 Sep 11;18:84-97
Temporal Proteomic Analysis of Herpes Simplex Virus 1 Infection Reveals Cell-Surface Remodeling via pUL56-Mediated GOPC Degradation.
Soh TK, Davies CTR, Muenzner J, Hunter LM, Barrow HG, Connor V, Bouton CR, Smith C, Emmott E, Antrobus R, Graham SC, Weekes MP, Crump CM
Cell reports 2020 Oct 6;33(1):108235
Cell reports 2020 Oct 6;33(1):108235
Caveolin 1 is required for axonal outgrowth of motor neurons and affects Xenopus neuromuscular development.
Breuer M, Berger H, Borchers A
Scientific reports 2020 Oct 5;10(1):16446
Scientific reports 2020 Oct 5;10(1):16446
A substrate-trapping strategy to find E3 ubiquitin ligase substrates identifies Parkin and TRIM28 targets.
Watanabe M, Saeki Y, Takahashi H, Ohtake F, Yoshida Y, Kasuga Y, Kondo T, Yaguchi H, Suzuki M, Ishida H, Tanaka K, Hatakeyama S
Communications biology 2020 Oct 20;3(1):592
Communications biology 2020 Oct 20;3(1):592
Functional interrogation of HOXA9 regulome in MLLr leukemia via reporter-based CRISPR/Cas9 screen.
Zhang H, Zhang Y, Zhou X, Wright S, Hyle J, Zhao L, An J, Zhao X, Shao Y, Xu B, Lee HM, Chen T, Zhou Y, Chen X, Lu R, Li C
eLife 2020 Oct 1;9
eLife 2020 Oct 1;9
Neuropilin-1 is up-regulated by cancer-associated fibroblast-secreted IL-8 and associated with cell proliferation of gallbladder cancer.
Chen C, Zhang R, Ma L, Li Q, Zhao YL, Zhang GJ, Zhang D, Li WZ, Cao S, Wang L, Geng ZM
Journal of cellular and molecular medicine 2020 Nov;24(21):12608-12618
Journal of cellular and molecular medicine 2020 Nov;24(21):12608-12618
Age-induced mitochondrial DNA point mutations are inadequate to alter metabolic homeostasis in response to nutrient challenge.
Moore TM, Zhou Z, Strumwasser AR, Cohn W, Lin AJ, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Hoang AN, Widjaja K, Abrishami AD, Charugundla S, Stiles L, Whitelegge JP, Turcotte LP, Wanagat J, Hevener AL
Aging cell 2020 Nov;19(11):e13166
Aging cell 2020 Nov;19(11):e13166
Impairment of adenosinergic system in Rett syndrome: Novel therapeutic target to boost BDNF signalling.
Miranda-Lourenço C, Duarte ST, Palminha C, Gaspar C, Rodrigues TM, Magalhães-Cardoso T, Rei N, Colino-Oliveira M, Gomes R, Ferreira S, Rosa J, Xapelli S, Armstrong J, García-Cazorla À, Correia-de-Sá P, Sebastião AM, Diógenes MJ
Neurobiology of disease 2020 Nov;145:105043
Neurobiology of disease 2020 Nov;145:105043
Dissecting the transactivation domain (tAD) of the transcription factor c-Myb to assess recent models of tAD function.
Naes G, Storesund JO, Udayakumar PD, Ledsaak M, Gabrielsen OS
FEBS open bio 2020 Nov;10(11):2329-2342
FEBS open bio 2020 Nov;10(11):2329-2342
The absence of (TCAGGG)(n) repeats in some telomeres, combined with variable responses to NR2F2 depletion, suggest that this nuclear receptor plays an indirect role in the alternative lengthening of telomeres.
Alhendi ASN, Royle NJ
Scientific reports 2020 Nov 26;10(1):20597
Scientific reports 2020 Nov 26;10(1):20597
Connexin43 Region 266-283, via Src Inhibition, Reduces Neural Progenitor Cell Proliferation Promoted by EGF and FGF-2 and Increases Astrocytic Differentiation.
Talaverón R, Matarredona ER, Herrera A, Medina JM, Tabernero A
International journal of molecular sciences 2020 Nov 23;21(22)
International journal of molecular sciences 2020 Nov 23;21(22)
Astrocytic phagocytosis is a compensatory mechanism for microglial dysfunction.
Konishi H, Okamoto T, Hara Y, Komine O, Tamada H, Maeda M, Osako F, Kobayashi M, Nishiyama A, Kataoka Y, Takai T, Udagawa N, Jung S, Ozato K, Tamura T, Tsuda M, Yamanaka K, Ogi T, Sato K, Kiyama H
The EMBO journal 2020 Nov 16;39(22):e104464
The EMBO journal 2020 Nov 16;39(22):e104464
Phosphorylation of Ykt6 SNARE Domain Regulates Its Membrane Recruitment and Activity.
Karuna M P, Witte L, Linnemannstoens K, Choezom D, Danieli-Mackay A, Honemann-Capito M, Gross JC
Biomolecules 2020 Nov 16;10(11)
Biomolecules 2020 Nov 16;10(11)
USP7 regulates ALS-associated proteotoxicity and quality control through the NEDD4L-SMAD pathway.
Zhang T, Periz G, Lu YN, Wang J
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 10;117(45):28114-28125
Proceedings of the National Academy of Sciences of the United States of America 2020 Nov 10;117(45):28114-28125
Ste20-like Kinase-mediated Control of Actin Polymerization Is a New Mechanism for Thin Filament-associated Regulation of Airway Smooth Muscle Contraction.
Wang Y, Wang R, Tang DD
American journal of respiratory cell and molecular biology 2020 May;62(5):645-656
American journal of respiratory cell and molecular biology 2020 May;62(5):645-656
Different training intensities induced autophagy and histopathology appearances potentially associated with lipid metabolism in wistar rat liver.
Gunadi JW, Tarawan VM, Daniel Ray HR, Wahyudianingsih R, Lucretia T, Tanuwijaya F, Lesmana R, Supratman U, Setiawan I
Heliyon 2020 May;6(5):e03874
Heliyon 2020 May;6(5):e03874
A transcriptional roadmap for 2C-like-to-pluripotent state transition.
Fu X, Djekidel MN, Zhang Y
Science advances 2020 May;6(22):eaay5181
Science advances 2020 May;6(22):eaay5181
Human THO maintains the stability of repetitive DNA.
Katahira J, Senokuchi K, Hieda M
Genes to cells : devoted to molecular & cellular mechanisms 2020 May;25(5):334-342
Genes to cells : devoted to molecular & cellular mechanisms 2020 May;25(5):334-342
Nek2-mediated GAS2L1 phosphorylation and centrosome-linker disassembly induce centrosome disjunction.
Au FKC, Hau BKT, Qi RZ
The Journal of cell biology 2020 May 4;219(5)
The Journal of cell biology 2020 May 4;219(5)
TRPV4 disrupts mitochondrial transport and causes axonal degeneration via a CaMKII-dependent elevation of intracellular Ca(2).
Woolums BM, McCray BA, Sung H, Tabuchi M, Sullivan JM, Ruppell KT, Yang Y, Mamah C, Aisenberg WH, Saavedra-Rivera PC, Larin BS, Lau AR, Robinson DN, Xiang Y, Wu MN, Sumner CJ, Lloyd TE
Nature communications 2020 May 29;11(1):2679
Nature communications 2020 May 29;11(1):2679
Insights into herpesvirus assembly from the structure of the pUL7:pUL51 complex.
Butt BG, Owen DJ, Jeffries CM, Ivanova L, Hill CH, Houghton JW, Ahmed MF, Antrobus R, Svergun DI, Welch JJ, Crump CM, Graham SC
eLife 2020 May 11;9
eLife 2020 May 11;9
Loss of High-Mobility Group Box 1 (HMGB1) Protein in Rods Accelerates Rod Photoreceptor Degeneration After Retinal Detachment.
Ross BX, Choi J, Yao J, Hager HM, Abcouwer SF, Zacks DN
Investigative ophthalmology & visual science 2020 May 11;61(5):50
Investigative ophthalmology & visual science 2020 May 11;61(5):50
Proteasomal-Mediated Degradation of AKAP150 Accompanies AMPAR Endocytosis during cLTD.
Cheng W, Siedlecki-Wullich D, Català-Solsona J, Fábregas C, Fadó R, Casals N, Solé M, Unzeta M, Saura CA, Rodríguez-Alvarez J, Miñano-Molina AJ
eNeuro 2020 Mar Apr;7(2)
eNeuro 2020 Mar Apr;7(2)
A tripartite cooperative mechanism confers resistance of the protein kinase A catalytic subunit to dephosphorylation.
Chan TO, Armen RS, Yadav S, Shah S, Zhang J, Tiegs BC, Keny N, Blumhof B, Deshpande DA, Rodeck U, Penn RB
The Journal of biological chemistry 2020 Mar 6;295(10):3316-3329
The Journal of biological chemistry 2020 Mar 6;295(10):3316-3329
Splicing Kinetics and Coordination Revealed by Direct Nascent RNA Sequencing through Nanopores.
Drexler HL, Choquet K, Churchman LS
Molecular cell 2020 Mar 5;77(5):985-998.e8
Molecular cell 2020 Mar 5;77(5):985-998.e8
Cyclophilin A Prevents HIV-1 Restriction in Lymphocytes by Blocking Human TRIM5α Binding to the Viral Core.
Selyutina A, Persaud M, Simons LM, Bulnes-Ramos A, Buffone C, Martinez-Lopez A, Scoca V, Di Nunzio F, Hiatt J, Marson A, Krogan NJ, Hultquist JF, Diaz-Griffero F
Cell reports 2020 Mar 17;30(11):3766-3777.e6
Cell reports 2020 Mar 17;30(11):3766-3777.e6
Glioblastoma initiating cells are sensitive to histone demethylase inhibition due to epigenetic deregulation.
Mallm JP, Windisch P, Biran A, Gal Z, Schumacher S, Glass R, Herold-Mende C, Meshorer E, Barbus M, Rippe K
International journal of cancer 2020 Mar 1;146(5):1281-1292
International journal of cancer 2020 Mar 1;146(5):1281-1292
Quantitative analysis of Y-Chromosome gene expression across 36 human tissues.
Godfrey AK, Naqvi S, Chmátal L, Chick JM, Mitchell RN, Gygi SP, Skaletsky H, Page DC
Genome research 2020 Jun;30(6):860-873
Genome research 2020 Jun;30(6):860-873
Abl-mediated PI3K activation regulates macrophage podosome formation.
Zhou Y, Feng Z, Cao F, Liu X, Xia X, Yu CH
Journal of cell science 2020 Jun 8;133(11)
Journal of cell science 2020 Jun 8;133(11)
Alternative polyadenylation mediates genetic regulation of gene expression.
Mittleman BE, Pott S, Warland S, Zeng T, Mu Z, Kaur M, Gilad Y, Li Y
eLife 2020 Jun 25;9
eLife 2020 Jun 25;9
Human GBP1 binds LPS to initiate assembly of a caspase-4 activating platform on cytosolic bacteria.
Santos JC, Boucher D, Schneider LK, Demarco B, Dilucca M, Shkarina K, Heilig R, Chen KW, Lim RYH, Broz P
Nature communications 2020 Jun 24;11(1):3276
Nature communications 2020 Jun 24;11(1):3276
Characterization of MORN2 stability and regulatory function in LC3-associated phagocytosis in macrophages.
Morita M, Kajiye M, Sakurai C, Kubo S, Takahashi M, Kinoshita D, Hori N, Hatsuzawa K
Biology open 2020 Jun 23;9(6)
Biology open 2020 Jun 23;9(6)
Phenotypic Screen with TSC-Deficient Neurons Reveals Heat-Shock Machinery as a Druggable Pathway for mTORC1 and Reduced Cilia.
Di Nardo A, Lenoël I, Winden KD, Rühmkorf A, Modi ME, Barrett L, Ercan-Herbst E, Venugopal P, Behne R, Lopes CAM, Kleiman RJ, Bettencourt-Dias M, Sahin M
Cell reports 2020 Jun 23;31(12):107780
Cell reports 2020 Jun 23;31(12):107780
Rab27a Contributes to the Processing of Inflammatory Pain in Mice.
Gross T, Wack G, Syhr KMJ, Tolmachova T, Seabra MC, Geisslinger G, Niederberger E, Schmidtko A, Kallenborn-Gerhardt W
Cells 2020 Jun 18;9(6)
Cells 2020 Jun 18;9(6)
Prostatic osteopontin expression is associated with symptomatic benign prostatic hyperplasia.
Popovics P, Awadallah WN, Kohrt SE, Case TC, Miller NL, Ricke EA, Huang W, Ramirez-Solano M, Liu Q, Vezina CM, Matusik RJ, Ricke WA, Grabowska MM
The Prostate 2020 Jul;80(10):731-741
The Prostate 2020 Jul;80(10):731-741
The branched-chain amino acids valine and leucine have differential effects on hepatic lipid metabolism.
Bishop CA, Schulze MB, Klaus S, Weitkunat K
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9727-9739
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2020 Jul;34(7):9727-9739
Wnt/β-catenin-activated Ewing sarcoma cells promote the angiogenic switch.
Hawkins AG, Pedersen EA, Treichel S, Temprine K, Sperring C, Read JA, Magnuson B, Chugh R, Lawlor ER
JCI insight 2020 Jul 9;5(13)
JCI insight 2020 Jul 9;5(13)
Sex-specific features of spine densities in the hippocampus.
Brandt N, Löffler T, Fester L, Rune GM
Scientific reports 2020 Jul 9;10(1):11405
Scientific reports 2020 Jul 9;10(1):11405
Enteroids Derived From Inflammatory Bowel Disease Patients Display Dysregulated Endoplasmic Reticulum Stress Pathways, Leading to Differential Inflammatory Responses and Dendritic Cell Maturation.
Rees WD, Stahl M, Jacobson K, Bressler B, Sly LM, Vallance BA, Steiner TS
Journal of Crohn's & colitis 2020 Jul 30;14(7):948-961
Journal of Crohn's & colitis 2020 Jul 30;14(7):948-961
Osmotic gradients induce stable dome morphogenesis on extracellular matrix.
Ishida-Ishihara S, Akiyama M, Furusawa K, Naguro I, Ryuno H, Sushida T, Ishihara S, Haga H
Journal of cell science 2020 Jul 27;133(14)
Journal of cell science 2020 Jul 27;133(14)
The Role of miR-375-3p and miR-200b-3p in Gastrointestinal Stromal Tumors.
Gyvyte U, Lukosevicius R, Inciuraite R, Streleckiene G, Gudoityte G, Bekampyte J, Valentini S, Salteniene V, Ruzgys P, Satkauskas S, Zviniene K, Kupcinskas J, Skieceviciene J
International journal of molecular sciences 2020 Jul 21;21(14)
International journal of molecular sciences 2020 Jul 21;21(14)
A cytoskeleton regulator AVIL drives tumorigenesis in glioblastoma.
Xie Z, Janczyk PŁ, Zhang Y, Liu A, Shi X, Singh S, Facemire L, Kubow K, Li Z, Jia Y, Schafer D, Mandell JW, Abounader R, Li H
Nature communications 2020 Jul 10;11(1):3457
Nature communications 2020 Jul 10;11(1):3457
The role of polo-like kinase 3 in the response of BRAF-mutant cells to targeted anticancer therapies.
Babagana M, Kichina JV, Slabodkin H, Johnson S, Maslov A, Brown L, Attwood K, Nikiforov MA, Kandel ES
Molecular carcinogenesis 2020 Jan;59(1):5-14
Molecular carcinogenesis 2020 Jan;59(1):5-14
Additive Therapeutic Effects of Mesenchymal Stem Cells and IL-37 for Systemic Lupus Erythematosus.
Xu J, Chen J, Li W, Lian W, Huang J, Lai B, Li L, Huang Z
Journal of the American Society of Nephrology : JASN 2020 Jan;31(1):54-65
Journal of the American Society of Nephrology : JASN 2020 Jan;31(1):54-65
An RNA guanine quadruplex regulated pathway to TRAIL-sensitization by DDX21.
McRae EKS, Dupas SJ, Booy EP, Piragasam RS, Fahlman RP, McKenna SA
RNA (New York, N.Y.) 2020 Jan;26(1):44-57
RNA (New York, N.Y.) 2020 Jan;26(1):44-57
miR-20b and miR-451a Are Involved in Gastric Carcinogenesis through the PI3K/AKT/mTOR Signaling Pathway: Data from Gastric Cancer Patients, Cell Lines and Ins-Gas Mouse Model.
Streleckiene G, Inciuraite R, Juzenas S, Salteniene V, Steponaitiene R, Gyvyte U, Kiudelis G, Leja M, Ruzgys P, Satkauskas S, Kupcinskiene E, Franke S, Thon C, Link A, Kupcinskas J, Skieceviciene J
International journal of molecular sciences 2020 Jan 29;21(3)
International journal of molecular sciences 2020 Jan 29;21(3)
Bim contributes to the progression of Huntington's disease-associated phenotypes.
Roberts SL, Evans T, Yang Y, Fu Y, Button RW, Sipthorpe RJ, Cowan K, Valionyte E, Anichtchik O, Li H, Lu B, Luo S
Human molecular genetics 2020 Jan 15;29(2):216-227
Human molecular genetics 2020 Jan 15;29(2):216-227
AKT signaling promotes DNA damage accumulation and proliferation in polycystic kidney disease.
Conduit SE, Davies EM, Ooms LM, Gurung R, McGrath MJ, Hakim S, Cottle DL, Smyth IM, Dyson JM, Mitchell CA
Human molecular genetics 2020 Jan 1;29(1):31-48
Human molecular genetics 2020 Jan 1;29(1):31-48
Context-dependent activation of SIRT3 is necessary for anchorage-independent survival and metastasis of ovarian cancer cells.
Kim YS, Gupta Vallur P, Jones VM, Worley BL, Shimko S, Shin DH, Crawford LC, Chen CW, Aird KM, Abraham T, Shepherd TG, Warrick JI, Lee NY, Phaeton R, Mythreye K, Hempel N
Oncogene 2020 Feb;39(8):1619-1633
Oncogene 2020 Feb;39(8):1619-1633
Transcriptome signature of ventricular arrhythmia in dilated cardiomyopathy reveals increased fibrosis and activated TP53.
Haywood ME, Cocciolo A, Porter KF, Dobrinskikh E, Slavov D, Graw SL, Reece TB, Ambardekar AV, Bristow MR, Mestroni L, Taylor MRG
Journal of molecular and cellular cardiology 2020 Feb;139:124-134
Journal of molecular and cellular cardiology 2020 Feb;139:124-134
Bi-allelic Variants in RALGAPA1 Cause Profound Neurodevelopmental Disability, Muscular Hypotonia, Infantile Spasms, and Feeding Abnormalities.
Wagner M, Skorobogatko Y, Pode-Shakked B, Powell CM, Alhaddad B, Seibt A, Barel O, Heimer G, Hoffmann C, Demmer LA, Perilla-Young Y, Remke M, Wieczorek D, Navaratnarajah T, Lichtner P, Klee D, Shamseldin HE, Al Mutairi F, Mayatepek E, Strom T, Meitinger T, Alkuraya FS, Anikster Y, Saltiel AR, Distelmaier F
American journal of human genetics 2020 Feb 6;106(2):246-255
American journal of human genetics 2020 Feb 6;106(2):246-255
Systematic Identification of Regulators of Oxidative Stress Reveals Non-canonical Roles for Peroxisomal Import and the Pentose Phosphate Pathway.
Dubreuil MM, Morgens DW, Okumoto K, Honsho M, Contrepois K, Lee-McMullen B, Traber GM, Sood RS, Dixon SJ, Snyder MP, Fujiki Y, Bassik MC
Cell reports 2020 Feb 4;30(5):1417-1433.e7
Cell reports 2020 Feb 4;30(5):1417-1433.e7
Septin2 mediates podosome maturation and endothelial cell invasion associated with angiogenesis.
Collins KB, Kang H, Matsche J, Klomp JE, Rehman J, Malik AB, Karginov AV
The Journal of cell biology 2020 Feb 3;219(2)
The Journal of cell biology 2020 Feb 3;219(2)
Low Doses of Methylmercury Induce the Proliferation of Thyroid Cells In Vitro Through Modulation of ERK Pathway.
Maggisano V, Bulotta S, Celano M, Maiuolo J, Lepore SM, Abballe L, Iannone M, Russo D
International journal of molecular sciences 2020 Feb 25;21(5)
International journal of molecular sciences 2020 Feb 25;21(5)
Targeting metabolic plasticity in glioma stem cells in vitro and in vivo through specific inhibition of c-Src by TAT-Cx43(266-283).
Pelaz SG, Jaraíz-Rodríguez M, Álvarez-Vázquez A, Talaverón R, García-Vicente L, Flores-Hernández R, Gómez de Cedrón M, Tabernero M, Ramírez de Molina A, Lillo C, Medina JM, Tabernero A
EBioMedicine 2020 Dec;62:103134
EBioMedicine 2020 Dec;62:103134
Loss of TREM2 Confers Resilience to Synaptic and Cognitive Impairment in Aged Mice.
Qu W, Li L
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Dec 9;40(50):9552-9563
The Journal of neuroscience : the official journal of the Society for Neuroscience 2020 Dec 9;40(50):9552-9563
Low Dose of β-Carotene Regulates Inflammation, Reduces Caspase Signaling, and Correlates with Autophagy Activation in Cardiomyoblast Cell Lines.
Lesmana R, Felia Yusuf I, Goenawan H, Achadiyani A, Khairani AF, Nur Fatimah S, Supratman U
Medical science monitor basic research 2020 Dec 28;26:e928648
Medical science monitor basic research 2020 Dec 28;26:e928648
An ACE2 Microbody Containing a Single Immunoglobulin Fc Domain Is a Potent Inhibitor of SARS-CoV-2.
Tada T, Fan C, Chen JS, Kaur R, Stapleford KA, Gristick H, Dcosta BM, Wilen CB, Nimigean CM, Landau NR
Cell reports 2020 Dec 22;33(12):108528
Cell reports 2020 Dec 22;33(12):108528
Mouse Ifit1b is a cap1-RNA-binding protein that inhibits mouse coronavirus translation and is regulated by complexing with Ifit1c.
Mears HV, Sweeney TR
The Journal of biological chemistry 2020 Dec 18;295(51):17781-17801
The Journal of biological chemistry 2020 Dec 18;295(51):17781-17801
Paired Box 9 (PAX9), the RNA polymerase II transcription factor, regulates human ribosome biogenesis and craniofacial development.
Farley-Barnes KI, Deniz E, Overton MM, Khokha MK, Baserga SJ
PLoS genetics 2020 Aug;16(8):e1008967
PLoS genetics 2020 Aug;16(8):e1008967
The Minor Matrix Protein VP24 from Ebola Virus Lacks Direct Lipid-Binding Properties.
Su Y, Stahelin RV
Viruses 2020 Aug 8;12(8)
Viruses 2020 Aug 8;12(8)
Talin1 controls dendritic cell activation by regulating TLR complex assembly and signaling.
Lim TJF, Bunjamin M, Ruedl C, Su IH
The Journal of experimental medicine 2020 Aug 3;217(8)
The Journal of experimental medicine 2020 Aug 3;217(8)
Metformin and Everolimus: A Promising Combination for Neuroendocrine Tumors Treatment.
Vitali E, Boemi I, Tarantola G, Piccini S, Zerbi A, Veronesi G, Baldelli R, Mazziotti G, Smiroldo V, Lavezzi E, Spada A, Mantovani G, Lania AG
Cancers 2020 Aug 2;12(8)
Cancers 2020 Aug 2;12(8)
Ykt6-dependent endosomal recycling is required for Wnt secretion in the Drosophila wing epithelium.
Linnemannstöns K, Witte L, Karuna M P, Kittel JC, Danieli A, Müller D, Nitsch L, Honemann-Capito M, Grawe F, Wodarz A, Gross JC
Development (Cambridge, England) 2020 Aug 14;147(15)
Development (Cambridge, England) 2020 Aug 14;147(15)
miR-125 family regulates XIRP1 and FIH in response to myocardial infarction.
Williams AL, Khadka VS, Anagaran MCT, Lee K, Avelar A, Deng Y, Shohet RV
Physiological genomics 2020 Aug 1;52(8):358-368
Physiological genomics 2020 Aug 1;52(8):358-368
CRISPR screens in cancer spheroids identify 3D growth-specific vulnerabilities.
Han K, Pierce SE, Li A, Spees K, Anderson GR, Seoane JA, Lo YH, Dubreuil M, Olivas M, Kamber RA, Wainberg M, Kostyrko K, Kelly MR, Yousefi M, Simpkins SW, Yao D, Lee K, Kuo CJ, Jackson PK, Sweet-Cordero A, Kundaje A, Gentles AJ, Curtis C, Winslow MM, Bassik MC
Nature 2020 Apr;580(7801):136-141
Nature 2020 Apr;580(7801):136-141
Recombinant human ADAMTS13 treatment and anti-NET strategies enhance skin allograft survival in mice.
Wong SL, Goverman J, Staudinger C, Wagner DD
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Apr;20(4):1162-1169
American journal of transplantation : official journal of the American Society of Transplantation and the American Society of Transplant Surgeons 2020 Apr;20(4):1162-1169
Exercise rejuvenates quiescent skeletal muscle stem cells in old mice through restoration of Cyclin D1.
Brett JO, Arjona M, Ikeda M, Quarta M, de Morrée A, Egner IM, Perandini LA, Ishak HD, Goshayeshi A, Benjamin DI, Both P, Rodríguez-Mateo C, Betley MJ, Wyss-Coray T, Rando TA
Nature metabolism 2020 Apr;2(4):307-317
Nature metabolism 2020 Apr;2(4):307-317
Characterization of 7A5: A Human CD137 (4-1BB) Receptor Binding Monoclonal Antibody with Differential Agonist Properties That Promotes Antitumor Immunity.
Kotanides H, Sattler RM, Lebron MB, Carpenito C, Shen J, Li J, Surguladze D, Haidar JN, Burns C, Shen L, Inigo I, Pennello AL, Forest A, Chen X, Chin D, Sonyi A, Topper M, Boucher L, Sharma P, Zhang Y, Burtrum D, Novosiadly RD, Ludwig DL, Plowman GD, Kalos M
Molecular cancer therapeutics 2020 Apr;19(4):988-998
Molecular cancer therapeutics 2020 Apr;19(4):988-998
Sex differences in hypothalamic-pituitary-adrenal axis regulation after chronic unpredictable stress.
Palumbo MC, Dominguez S, Dong H
Brain and behavior 2020 Apr;10(4):e01586
Brain and behavior 2020 Apr;10(4):e01586
A Highly Selective Chemical Probe for Activin Receptor-like Kinases ALK4 and ALK5.
Hanke T, Wong JF, Berger BT, Abdi I, Berger LM, Tesch R, Tredup C, Bullock AN, Müller S, Knapp S
ACS chemical biology 2020 Apr 17;15(4):862-870
ACS chemical biology 2020 Apr 17;15(4):862-870
Sporadic activation of an oxidative stress-dependent NRF2-p53 signaling network in breast epithelial spheroids and premalignancies.
Pereira EJ, Burns JS, Lee CY, Marohl T, Calderon D, Wang L, Atkins KA, Wang CC, Janes KA
Science signaling 2020 Apr 14;13(627)
Science signaling 2020 Apr 14;13(627)
Enhancer of Zeste Homologue 2 Inhibition Attenuates TGF-β Dependent Hepatic Stellate Cell Activation and Liver Fibrosis.
Martin-Mateos R, De Assuncao TM, Arab JP, Jalan-Sakrikar N, Yaqoob U, Greuter T, Verma VK, Mathison AJ, Cao S, Lomberk G, Mathurin P, Urrutia R, Huebert RC, Shah VH
Cellular and molecular gastroenterology and hepatology 2019;7(1):197-209
Cellular and molecular gastroenterology and hepatology 2019;7(1):197-209
Ifit1 regulates norovirus infection and enhances the interferon response in murine macrophage-like cells.
Mears HV, Emmott E, Chaudhry Y, Hosmillo M, Goodfellow IG, Sweeney TR
Wellcome open research 2019;4:82
Wellcome open research 2019;4:82
Inhibition of Indoleamine 2,3 Dioxygenase Does Not Improve Cancer-Related Symptoms in a Murine Model of Human Papilloma Virus-Related Head and Neck Cancer.
Vichaya EG, Vermeer DW, Budac D, Lee A, Grossberg A, Vermeer PD, Lee JH, Dantzer R
International journal of tryptophan research : IJTR 2019;12:1178646919872508
International journal of tryptophan research : IJTR 2019;12:1178646919872508
Impaired Activity of Ryanodine Receptors Contributes to Calcium Mishandling in Cardiomyocytes of Metabolic Syndrome Rats.
Fernández-Miranda G, Romero-Garcia T, Barrera-Lechuga TP, Mercado-Morales M, Rueda A
Frontiers in physiology 2019;10:520
Frontiers in physiology 2019;10:520
TYK2 promotes malignant peripheral nerve sheath tumor progression through inhibition of cell death.
Qin W, Godec A, Zhang X, Zhu C, Shao J, Tao Y, Bu X, Hirbe AC
Cancer medicine 2019 Sep;8(11):5232-5241
Cancer medicine 2019 Sep;8(11):5232-5241
Sulforaphane-induced epigenetic regulation of Nrf2 expression by DNA methyltransferase in human Caco-2 cells.
Zhou JW, Wang M, Sun NX, Qing Y, Yin TF, Li C, Wu D
Oncology letters 2019 Sep;18(3):2639-2647
Oncology letters 2019 Sep;18(3):2639-2647
Mitigation of off-target toxicity in CRISPR-Cas9 screens for essential non-coding elements.
Tycko J, Wainberg M, Marinov GK, Ursu O, Hess GT, Ego BK, Aradhana, Li A, Truong A, Trevino AE, Spees K, Yao D, Kaplow IM, Greenside PG, Morgens DW, Phanstiel DH, Snyder MP, Bintu L, Greenleaf WJ, Kundaje A, Bassik MC
Nature communications 2019 Sep 6;10(1):4063
Nature communications 2019 Sep 6;10(1):4063
A novel human Cdh1 mutation impairs anaphase promoting complex/cyclosome activity resulting in microcephaly, psychomotor retardation, and epilepsy.
Rodríguez C, Sánchez-Morán I, Álvarez S, Tirado P, Fernández-Mayoralas DM, Calleja-Pérez B, Almeida Á, Fernández-Jaén A
Journal of neurochemistry 2019 Oct;151(1):103-115
Journal of neurochemistry 2019 Oct;151(1):103-115
Systematic Identification of Host Cell Regulators of Legionella pneumophila Pathogenesis Using a Genome-wide CRISPR Screen.
Jeng EE, Bhadkamkar V, Ibe NU, Gause H, Jiang L, Chan J, Jian R, Jimenez-Morales D, Stevenson E, Krogan NJ, Swaney DL, Snyder MP, Mukherjee S, Bassik MC
Cell host & microbe 2019 Oct 9;26(4):551-563.e6
Cell host & microbe 2019 Oct 9;26(4):551-563.e6
A Mechanism Linking Two Known Vulnerability Factors for Alcohol Abuse: Heightened Alcohol Stimulation and Low Striatal Dopamine D2 Receptors.
Bocarsly ME, da Silva E Silva D, Kolb V, Luderman KD, Shashikiran S, Rubinstein M, Sibley DR, Dobbs LK, Alvarez VA
Cell reports 2019 Oct 29;29(5):1147-1163.e5
Cell reports 2019 Oct 29;29(5):1147-1163.e5
CRH Promotes the Neurogenic Activity of Neural Stem Cells in the Adult Hippocampus.
Koutmani Y, Gampierakis IA, Polissidis A, Ximerakis M, Koutsoudaki PN, Polyzos A, Agrogiannis G, Karaliota S, Thomaidou D, Rubin LL, Politis PK, Karalis KP
Cell reports 2019 Oct 22;29(4):932-945.e7
Cell reports 2019 Oct 22;29(4):932-945.e7
Reducing EphA4 before disease onset does not affect survival in a mouse model of Amyotrophic Lateral Sclerosis.
Rué L, Timmers M, Lenaerts A, Smolders S, Poppe L, de Boer A, Van Den Bosch L, Van Damme P, Robberecht W, Lemmens R
Scientific reports 2019 Oct 1;9(1):14112
Scientific reports 2019 Oct 1;9(1):14112
PK-M2-mediated metabolic changes in breast cancer cells induced by ionizing radiation.
Zhang L, Bailleul J, Yazal T, Dong K, Sung D, Dao A, Gosa L, Nathanson D, Bhat K, Duhachek-Muggy S, Alli C, Dratver MB, Pajonk F, Vlashi E
Breast cancer research and treatment 2019 Nov;178(1):75-86
Breast cancer research and treatment 2019 Nov;178(1):75-86
Quantitating the epigenetic transformation contributing to cholesterol homeostasis using Gaussian process.
Wang C, Scott SM, Subramanian K, Loguercio S, Zhao P, Hutt DM, Farhat NY, Porter FD, Balch WE
Nature communications 2019 Nov 7;10(1):5052
Nature communications 2019 Nov 7;10(1):5052
Dorsal convergence of gastrula cells requires Vangl2 and an adhesion protein-dependent change in protrusive activity.
Prince DJ, Jessen JR
Development (Cambridge, England) 2019 Nov 25;146(22)
Development (Cambridge, England) 2019 Nov 25;146(22)
Genomic tagging of endogenous human ESCRT-I complex preserves ESCRT-mediated membrane-remodeling functions.
Hoffman HK, Fernandez MV, Groves NS, Freed EO, van Engelenburg SB
The Journal of biological chemistry 2019 Nov 1;294(44):16266-16281
The Journal of biological chemistry 2019 Nov 1;294(44):16266-16281
LPA Induces Keratinocyte Differentiation and Promotes Skin Barrier Function through the LPAR1/LPAR5-RHO-ROCK-SRF Axis.
Sumitomo A, Siriwach R, Thumkeo D, Ito K, Nakagawa R, Tanaka N, Tanabe K, Watanabe A, Kishibe M, Ishida-Yamamoto A, Honda T, Kabashima K, Aoki J, Narumiya S
The Journal of investigative dermatology 2019 May;139(5):1010-1022
The Journal of investigative dermatology 2019 May;139(5):1010-1022
Role of Ryanodine Type 2 Receptors in Elementary Ca(2+) Signaling in Arteries and Vascular Adaptive Responses.
Kaßmann M, Szijártó IA, García-Prieto CF, Fan G, Schleifenbaum J, Anistan YM, Tabeling C, Shi Y, le Noble F, Witzenrath M, Huang Y, Markó L, Nelson MT, Gollasch M
Journal of the American Heart Association 2019 May 7;8(9):e010090
Journal of the American Heart Association 2019 May 7;8(9):e010090
A protein quality control pathway regulated by linear ubiquitination.
van Well EM, Bader V, Patra M, Sánchez-Vicente A, Meschede J, Furthmann N, Schnack C, Blusch A, Longworth J, Petrasch-Parwez E, Mori K, Arzberger T, Trümbach D, Angersbach L, Showkat C, Sehr DA, Berlemann LA, Goldmann P, Clement AM, Behl C, Woerner AC, Saft C, Wurst W, Haass C, Ellrichmann G, Gold R, Dittmar G, Hipp MS, Hartl FU, Tatzelt J, Winklhofer KF
The EMBO journal 2019 May 2;38(9)
The EMBO journal 2019 May 2;38(9)
LXRα limits TGFβ-dependent hepatocellular carcinoma associated fibroblast differentiation.
Morén A, Bellomo C, Tsubakihara Y, Kardassis D, Mikulits W, Heldin CH, Moustakas A
Oncogenesis 2019 May 16;8(6):36
Oncogenesis 2019 May 16;8(6):36
Cross-Talk between Receptor Tyrosine Kinases AXL and ERBB3 Regulates Invadopodia Formation in Melanoma Cells.
Revach OY, Sandler O, Samuels Y, Geiger B
Cancer research 2019 May 15;79(10):2634-2648
Cancer research 2019 May 15;79(10):2634-2648
Adenosine and hyaluronan promote lung fibrosis and pulmonary hypertension in combined pulmonary fibrosis and emphysema.
Collum SD, Molina JG, Hanmandlu A, Bi W, Pedroza M, Mertens TCJ, Wareing N, Wei W, Wilson C, Sun W, Rajadas J, Bollyky PL, Philip KM, Ren D, Thandavarayan RA, Bruckner BA, Xia Y, Blackburn MR, Karmouty-Quintana H
Disease models & mechanisms 2019 May 15;12(5)
Disease models & mechanisms 2019 May 15;12(5)
Liver-specific knockdown of long-chain acyl-CoA synthetase 4 reveals its key role in VLDL-TG metabolism and phospholipid synthesis in mice fed a high-fat diet.
Singh AB, Kan CFK, Kraemer FB, Sobel RA, Liu J
American journal of physiology. Endocrinology and metabolism 2019 May 1;316(5):E880-E894
American journal of physiology. Endocrinology and metabolism 2019 May 1;316(5):E880-E894
Cleavage factor 25 deregulation contributes to pulmonary fibrosis through alternative polyadenylation.
Weng T, Ko J, Masamha CP, Xia Z, Xiang Y, Chen NY, Molina JG, Collum S, Mertens TC, Luo F, Philip K, Davies J, Huang J, Wilson C, Thandavarayan RA, Bruckner BA, Jyothula SS, Volcik KA, Li L, Han L, Li W, Assassi S, Karmouty-Quintana H, Wagner EJ, Blackburn MR
The Journal of clinical investigation 2019 May 1;129(5):1984-1999
The Journal of clinical investigation 2019 May 1;129(5):1984-1999
The impact of exercise on mitochondrial dynamics and the role of Drp1 in exercise performance and training adaptations in skeletal muscle.
Moore TM, Zhou Z, Cohn W, Norheim F, Lin AJ, Kalajian N, Strumwasser AR, Cory K, Whitney K, Ho T, Ho T, Lee JL, Rucker DH, Shirihai O, van der Bliek AM, Whitelegge JP, Seldin MM, Lusis AJ, Lee S, Drevon CA, Mahata SK, Turcotte LP, Hevener AL
Molecular metabolism 2019 Mar;21:51-67
Molecular metabolism 2019 Mar;21:51-67
Alteration of Autophagy Gene Expression by Different Intensity of Exercise in Gastrocnemius and Soleus Muscles of Wistar Rats.
Tarawan VM, Gunadi JW, Setiawan, Lesmana R, Goenawan H, Meilina DE, Sipayung JA, Wargasetia TL, Widowati W, Limyati Y, Supratman U
Journal of sports science & medicine 2019 Mar;18(1):146-154
Journal of sports science & medicine 2019 Mar;18(1):146-154
Cholesterol Metabolism Is a Druggable Axis that Independently Regulates Tau and Amyloid-β in iPSC-Derived Alzheimer's Disease Neurons.
van der Kant R, Langness VF, Herrera CM, Williams DA, Fong LK, Leestemaker Y, Steenvoorden E, Rynearson KD, Brouwers JF, Helms JB, Ovaa H, Giera M, Wagner SL, Bang AG, Goldstein LSB
Cell stem cell 2019 Mar 7;24(3):363-375.e9
Cell stem cell 2019 Mar 7;24(3):363-375.e9
GALNT3 Maintains the Epithelial State in Trophoblast Stem Cells.
Raghu D, Mobley RJ, Shendy NAM, Perry CH, Abell AN
Cell reports 2019 Mar 26;26(13):3684-3697.e7
Cell reports 2019 Mar 26;26(13):3684-3697.e7
Fatty Acid Synthesis and Degradation Interplay to Regulate the Oxidative Stress in Cancer Cells.
Mikalayeva V, Ceslevičienė I, Sarapinienė I, Žvikas V, Skeberdis VA, Jakštas V, Bordel S
International journal of molecular sciences 2019 Mar 18;20(6)
International journal of molecular sciences 2019 Mar 18;20(6)
Decreased Expression of Cilia Genes in Pancreatic Islets as a Risk Factor for Type 2 Diabetes in Mice and Humans.
Kluth O, Stadion M, Gottmann P, Aga H, Jähnert M, Scherneck S, Vogel H, Krus U, Seelig A, Ling C, Gerdes J, Schürmann A
Cell reports 2019 Mar 12;26(11):3027-3036.e3
Cell reports 2019 Mar 12;26(11):3027-3036.e3
GSK-3β protects fetal oocytes from premature death via modulating TAp63 expression in mice.
Wen J, Yan H, He M, Zhang T, Mu X, Wang H, Zhang H, Xia G, Wang C
BMC biology 2019 Mar 12;17(1):23
BMC biology 2019 Mar 12;17(1):23
Analysis of the Human Kinome and Phosphatome by Mass Cytometry Reveals Overexpression-Induced Effects on Cancer-Related Signaling.
Lun XK, Szklarczyk D, Gábor A, Dobberstein N, Zanotelli VRT, Saez-Rodriguez J, von Mering C, Bodenmiller B
Molecular cell 2019 Jun 6;74(5):1086-1102.e5
Molecular cell 2019 Jun 6;74(5):1086-1102.e5
p75 Neurotrophin Receptor Activation Regulates the Timing of the Maturation of Cortical Parvalbumin Interneuron Connectivity and Promotes Juvenile-like Plasticity in Adult Visual Cortex.
Baho E, Chattopadhyaya B, Lavertu-Jolin M, Mazziotti R, Awad PN, Chehrazi P, Groleau M, Jahannault-Talignani C, Vaucher E, Ango F, Pizzorusso T, Baroncelli L, Di Cristo G
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jun 5;39(23):4489-4510
The Journal of neuroscience : the official journal of the Society for Neuroscience 2019 Jun 5;39(23):4489-4510
The priming factor CAPS1 regulates dense-core vesicle acidification by interacting with rabconnectin3β/WDR7 in neuroendocrine cells.
Crummy E, Mani M, Thellman JC, Martin TFJ
The Journal of biological chemistry 2019 Jun 14;294(24):9402-9415
The Journal of biological chemistry 2019 Jun 14;294(24):9402-9415
Basal expression of interferon regulatory factor 1 drives intrinsic hepatocyte resistance to multiple RNA viruses.
Yamane D, Feng H, Rivera-Serrano EE, Selitsky SR, Hirai-Yuki A, Das A, McKnight KL, Misumi I, Hensley L, Lovell W, González-López O, Suzuki R, Matsuda M, Nakanishi H, Ohto-Nakanishi T, Hishiki T, Wauthier E, Oikawa T, Morita K, Reid LM, Sethupathy P, Kohara M, Whitmire JK, Lemon SM
Nature microbiology 2019 Jul;4(7):1096-1104
Nature microbiology 2019 Jul;4(7):1096-1104
Transcriptomic analysis reveals cell apoptotic signature modified by heparanase in melanoma cells.
Song T, Spillmann D
Journal of cellular and molecular medicine 2019 Jul;23(7):4559-4568
Journal of cellular and molecular medicine 2019 Jul;23(7):4559-4568
Myc and Dnmt1 impede the pluripotent to totipotent state transition in embryonic stem cells.
Fu X, Wu X, Djekidel MN, Zhang Y
Nature cell biology 2019 Jul;21(7):835-844
Nature cell biology 2019 Jul;21(7):835-844
Acute depletion of CTCF directly affects MYC regulation through loss of enhancer-promoter looping.
Hyle J, Zhang Y, Wright S, Xu B, Shao Y, Easton J, Tian L, Feng R, Xu P, Li C
Nucleic acids research 2019 Jul 26;47(13):6699-6713
Nucleic acids research 2019 Jul 26;47(13):6699-6713
Identification of intracellular cavin target proteins reveals cavin-PP1alpha interactions regulate apoptosis.
McMahon KA, Wu Y, Gambin Y, Sierecki E, Tillu VA, Hall T, Martel N, Okano S, Moradi SV, Ruelcke JE, Ferguson C, Yap AS, Alexandrov K, Hill MM, Parton RG
Nature communications 2019 Jul 22;10(1):3279
Nature communications 2019 Jul 22;10(1):3279
Shifting the balance of autophagy and proteasome activation reduces proteotoxic cell death: a novel therapeutic approach for restoring photoreceptor homeostasis.
Qiu Y, Yao J, Jia L, Thompson DA, Zacks DN
Cell death & disease 2019 Jul 18;10(8):547
Cell death & disease 2019 Jul 18;10(8):547
Musashi interaction with poly(A)-binding protein is required for activation of target mRNA translation.
Cragle CE, MacNicol MC, Byrum SD, Hardy LL, Mackintosh SG, Richardson WA, Gray NK, Childs GV, Tackett AJ, MacNicol AM
The Journal of biological chemistry 2019 Jul 12;294(28):10969-10986
The Journal of biological chemistry 2019 Jul 12;294(28):10969-10986
Bone Morphogenetic Protein 9 Regulates Early Lymphatic-Specified Endothelial Cell Expansion during Mouse Embryonic Stem Cell Differentiation.
Subileau M, Merdzhanova G, Ciais D, Collin-Faure V, Feige JJ, Bailly S, Vittet D
Stem cell reports 2019 Jan 8;12(1):98-111
Stem cell reports 2019 Jan 8;12(1):98-111
Interplay between post-translational cyclooxygenase-2 modifications and the metabolic and proteomic profile in a colorectal cancer cohort.
Prieto P, Jaén RI, Calle D, Gómez-Serrano M, Núñez E, Fernández-Velasco M, Martín-Sanz P, Alonso S, Vázquez J, Cerdán S, Peinado MÁ, Boscá L
World journal of gastroenterology 2019 Jan 28;25(4):433-446
World journal of gastroenterology 2019 Jan 28;25(4):433-446
E-cadherin, actin, microtubules and FAK dominate different spheroid formation phases and important elements of tissue integrity.
Smyrek I, Mathew B, Fischer SC, Lissek SM, Becker S, Stelzer EHK
Biology open 2019 Jan 24;8(1)
Biology open 2019 Jan 24;8(1)
Clinical resistance to crenolanib in acute myeloid leukemia due to diverse molecular mechanisms.
Zhang H, Savage S, Schultz AR, Bottomly D, White L, Segerdell E, Wilmot B, McWeeney SK, Eide CA, Nechiporuk T, Carlos A, Henson R, Lin C, Searles R, Ho H, Lam YL, Sweat R, Follit C, Jain V, Lind E, Borthakur G, Garcia-Manero G, Ravandi F, Kantarjian HM, Cortes J, Collins R, Buelow DR, Baker SD, Druker BJ, Tyner JW
Nature communications 2019 Jan 16;10(1):244
Nature communications 2019 Jan 16;10(1):244
Region-specific inhibition of 14-3-3 proteins induces psychomotor behaviors in mice.
Graham K, Zhang J, Qiao H, Wu Y, Zhou Y
NPJ schizophrenia 2019 Jan 14;5(1):1
NPJ schizophrenia 2019 Jan 14;5(1):1
Human antigen R mediated post-transcriptional regulation of inhibitors of apoptosis proteins in pancreatic cancer.
Lukosiute-Urboniene A, Jasukaitiene A, Silkuniene G, Barauskas V, Gulbinas A, Dambrauskas Z
World journal of gastroenterology 2019 Jan 14;25(2):205-219
World journal of gastroenterology 2019 Jan 14;25(2):205-219
Activation of PP2A and Inhibition of mTOR Synergistically Reduce MYC Signaling and Decrease Tumor Growth in Pancreatic Ductal Adenocarcinoma.
Allen-Petersen BL, Risom T, Feng Z, Wang Z, Jenny ZP, Thoma MC, Pelz KR, Morton JP, Sansom OJ, Lopez CD, Sheppard B, Christensen DJ, Ohlmeyer M, Narla G, Sears RC
Cancer research 2019 Jan 1;79(1):209-219
Cancer research 2019 Jan 1;79(1):209-219
Sensory nerves mediate spontaneous behaviors in addition to inflammation in a murine model of psoriasis.
Kodji X, Arkless KL, Kee Z, Cleary SJ, Aubdool AA, Evans E, Caton P, Pitchford SC, Brain SD
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):1578-1594
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Feb;33(2):1578-1594
Impaired Hepatic Phosphatidylcholine Synthesis Leads to Cholestasis in Mice Challenged With a High-Fat Diet.
Wan S, Kuipers F, Havinga R, Ando H, Vance DE, Jacobs RL, van der Veen JN
Hepatology communications 2019 Feb;3(2):262-276
Hepatology communications 2019 Feb;3(2):262-276
Identification of TEX101-associated Proteins Through Proteomic Measurement of Human Spermatozoa Homozygous for the Missense Variant rs35033974.
Schiza C, Korbakis D, Jarvi K, Diamandis EP, Drabovich AP
Molecular & cellular proteomics : MCP 2019 Feb;18(2):338-351
Molecular & cellular proteomics : MCP 2019 Feb;18(2):338-351
Autophagosome immunoisolation from GFP-LC3B mouse tissue.
Yao J, Qiu Y, Jia L, Zacks DN
Autophagy 2019 Feb;15(2):341-346
Autophagy 2019 Feb;15(2):341-346
Caveolin-1α regulates primary cilium length by controlling RhoA GTPase activity.
Rangel L, Bernabé-Rubio M, Fernández-Barrera J, Casares-Arias J, Millán J, Alonso MA, Correas I
Scientific reports 2019 Feb 4;9(1):1116
Scientific reports 2019 Feb 4;9(1):1116
Developmental Xist induction is mediated by enhanced splicing.
Stork C, Li Z, Lin L, Zheng S
Nucleic acids research 2019 Feb 20;47(3):1532-1543
Nucleic acids research 2019 Feb 20;47(3):1532-1543
Metabolic Changes in Spontaneously Hypertensive Rat Hearts Precede Cardiac Dysfunction and Left Ventricular Hypertrophy.
Li J, Kemp BA, Howell NL, Massey J, Mińczuk K, Huang Q, Chordia MD, Roy RJ, Patrie JT, Davogustto GE, Kramer CM, Epstein FH, Carey RM, Taegtmeyer H, Keller SR, Kundu BK
Journal of the American Heart Association 2019 Feb 19;8(4):e010926
Journal of the American Heart Association 2019 Feb 19;8(4):e010926
Gigaxonin E3 ligase governs ATG16L1 turnover to control autophagosome production.
Scrivo A, Codogno P, Bomont P
Nature communications 2019 Feb 15;10(1):780
Nature communications 2019 Feb 15;10(1):780
Insights into lipid accumulation in skeletal muscle in dysferlin-deficient mice.
Agarwal AK, Tunison K, Mitsche MA, McDonald JG, Garg A
Journal of lipid research 2019 Dec;60(12):2057-2073
Journal of lipid research 2019 Dec;60(12):2057-2073
Mitochondrial DNA Stress Signalling Protects the Nuclear Genome.
Wu Z, Oeck S, West AP, Mangalhara KC, Sainz AG, Newman LE, Zhang XO, Wu L, Yan Q, Bosenberg M, Liu Y, Sulkowski PL, Tripple V, Kaech SM, Glazer PM, Shadel GS
Nature metabolism 2019 Dec;1(12):1209-1218
Nature metabolism 2019 Dec;1(12):1209-1218
CIBER-CLAP (CIBERCV Cardioprotection Large Animal Platform): A multicenter preclinical network for testing reproducibility in cardiovascular interventions.
Rossello X, Rodriguez-Sinovas A, Vilahur G, Crisóstomo V, Jorge I, Zaragoza C, Zamorano JL, Bermejo J, Ordoñez A, Boscá L, Vázquez J, Badimón L, Sánchez-Margallo FM, Fernández-Avilés F, Garcia-Dorado D, Ibanez B
Scientific reports 2019 Dec 30;9(1):20290
Scientific reports 2019 Dec 30;9(1):20290
EphA4 loss improves social memory performance and alters dendritic spine morphology without changes in amyloid pathology in a mouse model of Alzheimer's disease.
Poppe L, Rué L, Timmers M, Lenaerts A, Storm A, Callaerts-Vegh Z, Courtand G, de Boer A, Smolders S, Van Damme P, Van Den Bosch L, D'Hooge R, De Strooper B, Robberecht W, Lemmens R
Alzheimer's research & therapy 2019 Dec 12;11(1):102
Alzheimer's research & therapy 2019 Dec 12;11(1):102
cGMP-dependent protein kinase II determines β-catenin accumulation that is essential for uterine decidualization in mice.
Zhang Y, Yan L, Liu J, Cui S, Qiu J
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1115-C1127
American journal of physiology. Cell physiology 2019 Dec 1;317(6):C1115-C1127
A time-resolved live cell imaging assay to identify small molecule inhibitors of FGF2 signaling.
Ahmed M, Legrand C, Yagüe Relimpio A, Beretta CA, Muschko A, Wegehingel S, Müller HM, Sehr P, Will DW, Lewis JD, Nickel W
FEBS letters 2019 Aug;593(16):2162-2176
FEBS letters 2019 Aug;593(16):2162-2176
Stimulated upregulation of HO-1 is associated with inadequate response of gastric and ovarian cancer cell lines to hyperthermia and cisplatin treatment.
Cesna V, Sukovas A, Jasukaitiene A, Silkuniene G, Paskauskas S, Dambrauskas Z, Gulbinas A
Oncology letters 2019 Aug;18(2):1961-1968
Oncology letters 2019 Aug;18(2):1961-1968
HDAC3 and HDAC8 are required for cilia assembly and elongation.
Park SA, Yoo H, Seol JH, Rhee K
Biology open 2019 Aug 9;8(8)
Biology open 2019 Aug 9;8(8)
Cytoplasmic DAXX drives SQSTM1/p62 phase condensation to activate Nrf2-mediated stress response.
Yang Y, Willis TL, Button RW, Strang CJ, Fu Y, Wen X, Grayson PRC, Evans T, Sipthorpe RJ, Roberts SL, Hu B, Zhang J, Lu B, Luo S
Nature communications 2019 Aug 21;10(1):3759
Nature communications 2019 Aug 21;10(1):3759
Time-Variant SRC Kinase Activation Determines Endothelial Permeability Response.
Klomp JE, Shaaya M, Matsche J, Rebiai R, Aaron JS, Collins KB, Huyot V, Gonzalez AM, Muller WA, Chew TL, Malik AB, Karginov AV
Cell chemical biology 2019 Aug 15;26(8):1081-1094.e6
Cell chemical biology 2019 Aug 15;26(8):1081-1094.e6
Targeting PFKFB3 alleviates cerebral ischemia-reperfusion injury in mice.
Burmistrova O, Olias-Arjona A, Lapresa R, Jimenez-Blasco D, Eremeeva T, Shishov D, Romanov S, Zakurdaeva K, Almeida A, Fedichev PO, Bolaños JP
Scientific reports 2019 Aug 12;9(1):11670
Scientific reports 2019 Aug 12;9(1):11670
ERp18 regulates activation of ATF6α during unfolded protein response.
Oka OB, van Lith M, Rudolf J, Tungkum W, Pringle MA, Bulleid NJ
The EMBO journal 2019 Aug 1;38(15):e100990
The EMBO journal 2019 Aug 1;38(15):e100990
Endothelial TFEB (Transcription Factor EB) Restrains IKK (IκB Kinase)-p65 Pathway to Attenuate Vascular Inflammation in Diabetic db/db Mice.
Song W, Zhang CL, Gou L, He L, Gong YY, Qu D, Zhao L, Jin N, Chan TF, Wang L, Tian XY, Luo JY, Huang Y
Arteriosclerosis, thrombosis, and vascular biology 2019 Apr;39(4):719-730
Arteriosclerosis, thrombosis, and vascular biology 2019 Apr;39(4):719-730
Recurrent somatic BRAF insertion (p.V504_R506dup): a tumor marker and a potential therapeutic target in pilocytic astrocytoma.
Khater F, Langlois S, Cassart P, Roy AM, Lajoie M, Healy J, Richer C, St-Onge P, Piché N, Perreault S, Cellot S, Marzouki M, Jabado N, Sinnett D
Oncogene 2019 Apr;38(16):2994-3002
Oncogene 2019 Apr;38(16):2994-3002
A role for phosphatidylcholine and phosphatidylethanolamine in hepatic insulin signaling.
van der Veen JN, Lingrell S, McCloskey N, LeBlond ND, Galleguillos D, Zhao YY, Curtis JM, Sipione S, Fullerton MD, Vance DE, Jacobs RL
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5045-5057
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2019 Apr;33(4):5045-5057
Glucocorticoid-Induced Autophagy Protects Osteocytes Against Oxidative Stress Through Activation of MAPK/ERK Signaling.
Kar R, Riquelme MA, Hua R, Jiang JX
JBMR plus 2019 Apr;3(4):e10077
JBMR plus 2019 Apr;3(4):e10077
m(6)A Regulates Neurogenesis and Neuronal Development by Modulating Histone Methyltransferase Ezh2.
Chen J, Zhang YC, Huang C, Shen H, Sun B, Cheng X, Zhang YJ, Yang YG, Shu Q, Yang Y, Li X
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168
Genomics, proteomics & bioinformatics 2019 Apr;17(2):154-168
Effects of Neddylation and mTOR Inhibition in Acute Myelogenous Leukemia.
Guo N, Azadniv M, Coppage M, Nemer M, Mendler J, Becker M, Liesveld J
Translational oncology 2019 Apr;12(4):602-613
Translational oncology 2019 Apr;12(4):602-613
Modeling Glycan Processing Reveals Golgi-Enzyme Homeostasis upon Trafficking Defects and Cellular Differentiation.
Fisher P, Spencer H, Thomas-Oates J, Wood AJ, Ungar D
Cell reports 2019 Apr 23;27(4):1231-1243.e6
Cell reports 2019 Apr 23;27(4):1231-1243.e6
High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.
Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S
Frontiers in physiology 2018;9:51
Frontiers in physiology 2018;9:51
Sulforaphane Inhibits Inflammatory Responses of Primary Human T-Cells by Increasing ROS and Depleting Glutathione.
Liang J, Jahraus B, Balta E, Ziegler JD, Hübner K, Blank N, Niesler B, Wabnitz GH, Samstag Y
Frontiers in immunology 2018;9:2584
Frontiers in immunology 2018;9:2584
Cadherin-26 (CDH26) regulates airway epithelial cell cytoskeletal structure and polarity.
Lachowicz-Scroggins ME, Gordon ED, Wesolowska-Andersen A, Jackson ND, MacLeod HJ, Sharp LZ, Sun M, Seibold MA, Fahy JV
Cell discovery 2018;4:7
Cell discovery 2018;4:7
Nutmeg Extract Increases Skeletal Muscle Mass in Aging Rats Partly via IGF1-AKT-mTOR Pathway and Inhibition of Autophagy.
Pratiwi YS, Lesmana R, Goenawan H, Sylviana N, Setiawan I, Tarawan VM, Lestari K, Abdulah R, Dwipa L, Purba A, Supratman U
Evidence-based complementary and alternative medicine : eCAM 2018;2018:2810840
Evidence-based complementary and alternative medicine : eCAM 2018;2018:2810840
Murine macrophage TLR2-FcγR synergy via FcγR licensing of IL-6 cytokine mRNA ribosome binding and translation.
Hunt D, Drake LA, Drake JR
PloS one 2018;13(7):e0200764
PloS one 2018;13(7):e0200764
Host-directed combinatorial RNAi improves inhibition of diverse strains of influenza A virus in human respiratory epithelial cells.
Estrin MA, Hussein ITM, Puryear WB, Kuan AC, Artim SC, Runstadler JA
PloS one 2018;13(5):e0197246
PloS one 2018;13(5):e0197246
CRB3 and the FERM protein EPB41L4B regulate proliferation of mammary epithelial cells through the release of amphiregulin.
Walker SJ, Selfors LM, Margolis BL, Brugge JS
PloS one 2018;13(11):e0207470
PloS one 2018;13(11):e0207470
Decreased Hippocampal Neuroplasticity and Behavioral Impairment in an Animal Model of Inhalant Abuse.
Malloul H, Bennis M, Bonzano S, Gambarotta G, Perroteau I, De Marchis S, Ba-M'hamed S
Frontiers in neuroscience 2018;12:35
Frontiers in neuroscience 2018;12:35
Oxidative stress and mitochondrial dynamics malfunction are linked in Pelizaeus-Merzbacher disease.
Ruiz M, Bégou M, Launay N, Ranea-Robles P, Bianchi P, López-Erauskin J, Morató L, Guilera C, Petit B, Vaurs-Barriere C, Guéret-Gonthier C, Bonnet-Dupeyron MN, Fourcade S, Auwerx J, Boespflug-Tanguy O, Pujol A
Brain pathology (Zurich, Switzerland) 2018 Sep;28(5):611-630
Brain pathology (Zurich, Switzerland) 2018 Sep;28(5):611-630
Distal Dendritic Enrichment of HCN1 Channels in Hippocampal CA1 Is Promoted by Estrogen, but Does Not Require Reelin.
Meseke M, Neumüller F, Brunne B, Li X, Anstötz M, Pohlkamp T, Rogalla MM, Herz J, Rune GM, Bender RA
eNeuro 2018 Sep-Oct;5(5)
eNeuro 2018 Sep-Oct;5(5)
Rapamycin and fasting sustain autophagy response activated by ischemia/reperfusion injury and promote retinal ganglion cell survival.
Russo R, Varano GP, Adornetto A, Nazio F, Tettamanti G, Girardello R, Cianfanelli V, Cavaliere F, Morrone LA, Corasaniti MT, Cecconi F, Bagetta G, Nucci C
Cell death & disease 2018 Sep 24;9(10):981
Cell death & disease 2018 Sep 24;9(10):981
Disruption of VEGF Mediated Flk-1 Signaling Leads to a Gradual Loss of Vessel Health and Cardiac Function During Myocardial Infarction: Potential Therapy With Pellino-1.
Thirunavukkarasu M, Selvaraju V, Joshi M, Coca-Soliz V, Tapias L, Saad I, Fournier C, Husain A, Campbell J, Yee SP, Sanchez JA, Palesty JA, McFadden DW, Maulik N
Journal of the American Heart Association 2018 Sep 18;7(18):e007601
Journal of the American Heart Association 2018 Sep 18;7(18):e007601
FOXO are required for intervertebral disk homeostasis during aging and their deficiency promotes disk degeneration.
Alvarez-Garcia O, Matsuzaki T, Olmer M, Miyata K, Mokuda S, Sakai D, Masuda K, Asahara H, Lotz MK
Aging cell 2018 Oct;17(5):e12800
Aging cell 2018 Oct;17(5):e12800
β(2)-Adrenergic receptor modulates mitochondrial metabolism and disease progression in recurrent/metastatic HPV(+) HNSCC.
Lucido CT, Callejas-Valera JL, Colbert PL, Vermeer DW, Miskimins WK, Spanos WC, Vermeer PD
Oncogenesis 2018 Oct 8;7(10):81
Oncogenesis 2018 Oct 8;7(10):81
The SUMO protease SENP1 and the chromatin remodeler CHD3 interact and jointly affect chromatin accessibility and gene expression.
Rodríguez-Castañeda F, Lemma RB, Cuervo I, Bengtsen M, Moen LM, Ledsaak M, Eskeland R, Gabrielsen OS
The Journal of biological chemistry 2018 Oct 5;293(40):15439-15454
The Journal of biological chemistry 2018 Oct 5;293(40):15439-15454
Specific PKC βII inhibitor: one stone two birds in the treatment of diabetic foot ulcers.
Das SK, Yuan YF, Li MQ
Bioscience reports 2018 Oct 31;38(5)
Bioscience reports 2018 Oct 31;38(5)
Cancer exosomes induce tumor innervation.
Madeo M, Colbert PL, Vermeer DW, Lucido CT, Cain JT, Vichaya EG, Grossberg AJ, Muirhead D, Rickel AP, Hong Z, Zhao J, Weimer JM, Spanos WC, Lee JH, Dantzer R, Vermeer PD
Nature communications 2018 Oct 16;9(1):4284
Nature communications 2018 Oct 16;9(1):4284
Disruption of GPR35 Exacerbates Dextran Sulfate Sodium-Induced Colitis in Mice.
Farooq SM, Hou Y, Li H, O'Meara M, Wang Y, Li C, Wang JM
Digestive diseases and sciences 2018 Nov;63(11):2910-2922
Digestive diseases and sciences 2018 Nov;63(11):2910-2922
SAMMSON fosters cancer cell fitness by concertedly enhancing mitochondrial and cytosolic translation.
Vendramin R, Verheyden Y, Ishikawa H, Goedert L, Nicolas E, Saraf K, Armaos A, Delli Ponti R, Izumikawa K, Mestdagh P, Lafontaine DLJ, Tartaglia GG, Takahashi N, Marine JC, Leucci E
Nature structural & molecular biology 2018 Nov;25(11):1035-1046
Nature structural & molecular biology 2018 Nov;25(11):1035-1046
Low temperature decreases bone mass in mice: Implications for humans.
Robbins A, Tom CATMB, Cosman MN, Moursi C, Shipp L, Spencer TM, Brash T, Devlin MJ
American journal of physical anthropology 2018 Nov;167(3):557-568
American journal of physical anthropology 2018 Nov;167(3):557-568
The α(2)δ-like Protein Cachd1 Increases N-type Calcium Currents and Cell Surface Expression and Competes with α(2)δ-1.
Dahimene S, Page KM, Kadurin I, Ferron L, Ho DY, Powell GT, Pratt WS, Wilson SW, Dolphin AC
Cell reports 2018 Nov 6;25(6):1610-1621.e5
Cell reports 2018 Nov 6;25(6):1610-1621.e5
Transcriptional response to Wnt activation regulates the regenerative capacity of the mammalian cochlea.
Samarajeewa A, Lenz DR, Xie L, Chiang H, Kirchner R, Mulvaney JF, Edge ASB, Dabdoub A
Development (Cambridge, England) 2018 Nov 27;145(23)
Development (Cambridge, England) 2018 Nov 27;145(23)
Anti-obesity activity of OBEX is regulated by activation of thermogenesis and decreasing adiposity gain.
Carreira MC, Andrade S, Gonzalez-Izquierdo A, Amil M, Folgueira C, Monteiro MP, Sanz E, Crujeiras AB, Casanueva FF
Scientific reports 2018 Nov 21;8(1):17155
Scientific reports 2018 Nov 21;8(1):17155
Vangl2-dependent regulation of membrane protrusions and directed migration requires a fibronectin extracellular matrix.
Love AM, Prince DJ, Jessen JR
Development (Cambridge, England) 2018 Nov 15;145(22)
Development (Cambridge, England) 2018 Nov 15;145(22)
KCC2 Regulates Dendritic Spine Formation in a Brain-Region Specific and BDNF Dependent Manner.
Awad PN, Amegandjin CA, Szczurkowska J, Carriço JN, Fernandes do Nascimento AS, Baho E, Chattopadhyaya B, Cancedda L, Carmant L, Di Cristo G
Cerebral cortex (New York, N.Y. : 1991) 2018 Nov 1;28(11):4049-4062
Cerebral cortex (New York, N.Y. : 1991) 2018 Nov 1;28(11):4049-4062
Selection and Characterization of Rupintrivir-Resistant Norwalk Virus Replicon Cells In Vitro.
Kitano M, Hosmillo M, Emmott E, Lu J, Goodfellow I
Antimicrobial agents and chemotherapy 2018 May;62(5)
Antimicrobial agents and chemotherapy 2018 May;62(5)
Snail regulates BMP and TGFβ pathways to control the differentiation status of glioma-initiating cells.
Caja L, Tzavlaki K, Dadras MS, Tan EJ, Hatem G, Maturi NP, Morén A, Wik L, Watanabe Y, Savary K, Kamali-Moghaddan M, Uhrbom L, Heldin CH, Moustakas A
Oncogene 2018 May;37(19):2515-2531
Oncogene 2018 May;37(19):2515-2531
Modulation of glutathione promotes apoptosis in triple-negative breast cancer cells.
Miran T, Vogg ATJ, Drude N, Mottaghy FM, Morgenroth A
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2803-2813
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2018 May;32(5):2803-2813
Snail mediates crosstalk between TGFβ and LXRα in hepatocellular carcinoma.
Bellomo C, Caja L, Fabregat I, Mikulits W, Kardassis D, Heldin CH, Moustakas A
Cell death and differentiation 2018 May;25(5):885-903
Cell death and differentiation 2018 May;25(5):885-903
Dimerization of the cellular prion protein inhibits propagation of scrapie prions.
Engelke AD, Gonsberg A, Thapa S, Jung S, Ulbrich S, Seidel R, Basu S, Multhaup G, Baier M, Engelhard M, Schätzl HM, Winklhofer KF, Tatzelt J
The Journal of biological chemistry 2018 May 25;293(21):8020-8031
The Journal of biological chemistry 2018 May 25;293(21):8020-8031
Neuronal adaptor FE65 stimulates Rac1-mediated neurite outgrowth by recruiting and activating ELMO1.
Li W, Tam KMV, Chan WWR, Koon AC, Ngo JCK, Chan HYE, Lau KF
The Journal of biological chemistry 2018 May 18;293(20):7674-7688
The Journal of biological chemistry 2018 May 18;293(20):7674-7688
Caspase-mediated cleavage of the centrosomal proteins during apoptosis.
Seo MY, Rhee K
Cell death & disease 2018 May 1;9(5):571
Cell death & disease 2018 May 1;9(5):571
Galectin-3 sensitized melanoma cell lines to vemurafenib (PLX4032) induced cell death through prevention of autophagy.
Bustos SO, da Silva Pereira GJ, de Freitas Saito R, Gil CD, Zanatta DB, Smaili SS, Chammas R
Oncotarget 2018 Mar 6;9(18):14567-14579
Oncotarget 2018 Mar 6;9(18):14567-14579
The actin-MRTF-SRF transcriptional circuit controls tubulin acetylation via α-TAT1 gene expression.
Fernández-Barrera J, Bernabé-Rubio M, Casares-Arias J, Rangel L, Fernández-Martín L, Correas I, Alonso MA
The Journal of cell biology 2018 Mar 5;217(3):929-944
The Journal of cell biology 2018 Mar 5;217(3):929-944
Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.
Mancini SJ, Boyd D, Katwan OJ, Strembitska A, Almabrouk TA, Kennedy S, Palmer TM, Salt IP
Scientific reports 2018 Mar 27;8(1):5276
Scientific reports 2018 Mar 27;8(1):5276
TDP43 nuclear export and neurodegeneration in models of amyotrophic lateral sclerosis and frontotemporal dementia.
Archbold HC, Jackson KL, Arora A, Weskamp K, Tank EM, Li X, Miguez R, Dayton RD, Tamir S, Klein RL, Barmada SJ
Scientific reports 2018 Mar 15;8(1):4606
Scientific reports 2018 Mar 15;8(1):4606
LPS targets host guanylate-binding proteins to the bacterial outer membrane for non-canonical inflammasome activation.
Santos JC, Dick MS, Lagrange B, Degrandi D, Pfeffer K, Yamamoto M, Meunier E, Pelczar P, Henry T, Broz P
The EMBO journal 2018 Mar 15;37(6)
The EMBO journal 2018 Mar 15;37(6)
HDAC6 is a therapeutic target in mutant GARS-induced Charcot-Marie-Tooth disease.
Benoy V, Van Helleputte L, Prior R, d'Ydewalle C, Haeck W, Geens N, Scheveneels W, Schevenels B, Cader MZ, Talbot K, Kozikowski AP, Vanden Berghe P, Van Damme P, Robberecht W, Van Den Bosch L
Brain : a journal of neurology 2018 Mar 1;141(3):673-687
Brain : a journal of neurology 2018 Mar 1;141(3):673-687
A homozygous variant disrupting the PIGH start-codon is associated with developmental delay, epilepsy, and microcephaly.
Pagnamenta AT, Murakami Y, Anzilotti C, Titheradge H, Oates AJ, Morton J, DDD Study, Kinoshita T, Kini U, Taylor JC
Human mutation 2018 Jun;39(6):822-826
Human mutation 2018 Jun;39(6):822-826
P300 Acetyltransferase Mediates Stiffness-Induced Activation of Hepatic Stellate Cells Into Tumor-Promoting Myofibroblasts.
Dou C, Liu Z, Tu K, Zhang H, Chen C, Yaqoob U, Wang Y, Wen J, van Deursen J, Sicard D, Tschumperlin D, Zou H, Huang WC, Urrutia R, Shah VH, Kang N
Gastroenterology 2018 Jun;154(8):2209-2221.e14
Gastroenterology 2018 Jun;154(8):2209-2221.e14
The oxidoreductase p66Shc acts as tumor suppressor in BRAFV600E-transformed cells.
Furlan T, Khalid S, Nguyen AV, Günther J, Troppmair J
Molecular oncology 2018 Jun;12(6):869-882
Molecular oncology 2018 Jun;12(6):869-882
Mouse medulloblastoma driven by CRISPR activation of cellular Myc.
Vo BT, Kwon JA, Li C, Finkelstein D, Xu B, Orr BA, Sherr CJ, Roussel MF
Scientific reports 2018 Jun 7;8(1):8733
Scientific reports 2018 Jun 7;8(1):8733
The AKAP Cypher/Zasp contributes to β-adrenergic/PKA stimulation of cardiac Ca(V)1.2 calcium channels.
Yu H, Yuan C, Westenbroek RE, Catterall WA
The Journal of general physiology 2018 Jun 4;150(6):883-889
The Journal of general physiology 2018 Jun 4;150(6):883-889
The pioneer factor activity of c-Myb involves recruitment of p300 and induction of histone acetylation followed by acetylation-induced chromatin dissociation.
Fuglerud BM, Ledsaak M, Rogne M, Eskeland R, Gabrielsen OS
Epigenetics & chromatin 2018 Jun 28;11(1):35
Epigenetics & chromatin 2018 Jun 28;11(1):35
Burkholderia Lethal Factor 1, a Novel Anti-Cancer Toxin, Demonstrates Selective Cytotoxicity in MYCN-Amplified Neuroblastoma Cells.
Rust A, Shah S, Hautbergue GM, Davletov B
Toxins 2018 Jun 27;10(7)
Toxins 2018 Jun 27;10(7)
Excess LINC complexes impair brain morphogenesis in a mouse model of recessive TOR1A disease.
Dominguez Gonzalez B, Billion K, Rous S, Pavie B, Lange C, Goodchild R
Human molecular genetics 2018 Jun 15;27(12):2154-2170
Human molecular genetics 2018 Jun 15;27(12):2154-2170
IFIT3 and IFIT2/3 promote IFIT1-mediated translation inhibition by enhancing binding to non-self RNA.
Fleith RC, Mears HV, Leong XY, Sanford TJ, Emmott E, Graham SC, Mansur DS, Sweeney TR
Nucleic acids research 2018 Jun 1;46(10):5269-5285
Nucleic acids research 2018 Jun 1;46(10):5269-5285
Continuous signaling of CD79b and CD19 is required for the fitness of Burkitt lymphoma B cells.
He X, Kläsener K, Iype JM, Becker M, Maity PC, Cavallari M, Nielsen PJ, Yang J, Reth M
The EMBO journal 2018 Jun 1;37(11)
The EMBO journal 2018 Jun 1;37(11)
The Balance of PI3K and ERK Signaling Is Dysregulated in Prolactinoma and Modulated by Dopamine.
Roof AK, Jirawatnotai S, Trudeau T, Kuzyk C, Wierman ME, Kiyokawa H, Gutierrez-Hartmann A
Endocrinology 2018 Jun 1;159(6):2421-2434
Endocrinology 2018 Jun 1;159(6):2421-2434
Menin regulates the serine biosynthetic pathway in Ewing sarcoma.
Svoboda LK, Teh SSK, Sud S, Kerk S, Zebolsky A, Treichel S, Thomas D, Halbrook CJ, Lee HJ, Kremer D, Zhang L, Klossowski S, Bankhead AR, Magnuson B, Ljungman M, Cierpicki T, Grembecka J, Lyssiotis CA, Lawlor ER
The Journal of pathology 2018 Jul;245(3):324-336
The Journal of pathology 2018 Jul;245(3):324-336
The structure of human Nocturnin reveals a conserved ribonuclease domain that represses target transcript translation and abundance in cells.
Abshire ET, Chasseur J, Bohn JA, Del Rizzo PA, Freddolino PL, Goldstrohm AC, Trievel RC
Nucleic acids research 2018 Jul 6;46(12):6257-6270
Nucleic acids research 2018 Jul 6;46(12):6257-6270
Proteomic and Biochemical Comparison of the Cellular Interaction Partners of Human VPS33A and VPS33B.
Hunter MR, Hesketh GG, Benedyk TH, Gingras AC, Graham SC
Journal of molecular biology 2018 Jul 6;430(14):2153-2163
Journal of molecular biology 2018 Jul 6;430(14):2153-2163
TRPC4/TRPC5 channels mediate adverse reaction to the cancer cell cytotoxic agent (-)-Englerin A.
Cheung SY, Henrot M, Al-Saad M, Baumann M, Muller H, Unger A, Rubaiy HN, Mathar I, Dinkel K, Nussbaumer P, Klebl B, Freichel M, Rode B, Trainor S, Clapcote SJ, Christmann M, Waldmann H, Abbas SK, Beech DJ, Vasudev NS
Oncotarget 2018 Jul 3;9(51):29634-29643
Oncotarget 2018 Jul 3;9(51):29634-29643
Identifying the druggable interactome of EWS-FLI1 reveals MCL-1 dependent differential sensitivities of Ewing sarcoma cells to apoptosis inducers.
Tsafou K, Katschnig AM, Radic-Sarikas B, Mutz CN, Iljin K, Schwentner R, Kauer MO, Mühlbacher K, Aryee DNT, Westergaard D, Haapa-Paananen S, Fey V, Superti-Furga G, Toretsky J, Brunak S, Kovar H
Oncotarget 2018 Jul 24;9(57):31018-31031
Oncotarget 2018 Jul 24;9(57):31018-31031
The Transcription Factor ThPOK Orchestrates Stochastic Interchromosomal Interactions Required for IFNB1 Virus-Inducible Gene Expression.
Nikopoulou C, Panagopoulos G, Sianidis G, Psarra E, Ford E, Thanos D
Molecular cell 2018 Jul 19;71(2):352-361.e5
Molecular cell 2018 Jul 19;71(2):352-361.e5
Notch1 is asymmetrically distributed from the beginning of embryogenesis and controls the ventral center.
Castro Colabianchi AM, Revinski DR, Encinas PI, Baez MV, Monti RJ, Rodríguez Abinal M, Kodjabachian L, Franchini LF, López SL
Development (Cambridge, England) 2018 Jul 17;145(14)
Development (Cambridge, England) 2018 Jul 17;145(14)
Synthetic lethality of TNK2 inhibition in PTPN11-mutant leukemia.
Jenkins C, Luty SB, Maxson JE, Eide CA, Abel ML, Togiai C, Nemecek ER, Bottomly D, McWeeney SK, Wilmot B, Loriaux M, Chang BH, Tyner JW
Science signaling 2018 Jul 17;11(539)
Science signaling 2018 Jul 17;11(539)
Combined inhibition of PI3K and Src kinases demonstrates synergistic therapeutic efficacy in clear-cell renal carcinoma.
Roelants C, Giacosa S, Pillet C, Bussat R, Champelovier P, Bastien O, Guyon L, Arnoux V, Cochet C, Filhol O
Oncotarget 2018 Jul 10;9(53):30066-30078
Oncotarget 2018 Jul 10;9(53):30066-30078
Mitochondrial redox sensing by the kinase ATM maintains cellular antioxidant capacity.
Zhang Y, Lee JH, Paull TT, Gehrke S, D'Alessandro A, Dou Q, Gladyshev VN, Schroeder EA, Steyl SK, Christian BE, Shadel GS
Science signaling 2018 Jul 10;11(538)
Science signaling 2018 Jul 10;11(538)
HIF1 mediates a switch in pyruvate kinase isoforms after myocardial infarction.
Williams AL, Khadka V, Tang M, Avelar A, Schunke KJ, Menor M, Shohet RV
Physiological genomics 2018 Jul 1;50(7):479-494
Physiological genomics 2018 Jul 1;50(7):479-494
Elevated dual specificity protein phosphatase 4 in cardiomyopathy caused by lamin A/C gene mutation is primarily ERK1/2-dependent and its depletion improves cardiac function and survival.
Choi JC, Wu W, Phillips E, Plevin R, Sera F, Homma S, Worman HJ
Human molecular genetics 2018 Jul 1;27(13):2290-2305
Human molecular genetics 2018 Jul 1;27(13):2290-2305
Identification of diverse target RNAs that are functionally regulated by human Pumilio proteins.
Bohn JA, Van Etten JL, Schagat TL, Bowman BM, McEachin RC, Freddolino PL, Goldstrohm AC
Nucleic acids research 2018 Jan 9;46(1):362-386
Nucleic acids research 2018 Jan 9;46(1):362-386
Cardiogenic programming of human pluripotent stem cells by dose-controlled activation of EOMES.
Pfeiffer MJ, Quaranta R, Piccini I, Fell J, Rao J, Röpke A, Seebohm G, Greber B
Nature communications 2018 Jan 30;9(1):440
Nature communications 2018 Jan 30;9(1):440
Identification of a Golgi GPI-N-acetylgalactosamine transferase with tandem transmembrane regions in the catalytic domain.
Hirata T, Mishra SK, Nakamura S, Saito K, Motooka D, Takada Y, Kanzawa N, Murakami Y, Maeda Y, Fujita M, Yamaguchi Y, Kinoshita T
Nature communications 2018 Jan 26;9(1):405
Nature communications 2018 Jan 26;9(1):405
RAPGEF5 Regulates Nuclear Translocation of β-Catenin.
Griffin JN, Del Viso F, Duncan AR, Robson A, Hwang W, Kulkarni S, Liu KJ, Khokha MK
Developmental cell 2018 Jan 22;44(2):248-260.e4
Developmental cell 2018 Jan 22;44(2):248-260.e4
The protein kinase SIK downregulates the polarity protein Par3.
Vanlandewijck M, Dadras MS, Lomnytska M, Mahzabin T, Lee Miller M, Busch C, Brunak S, Heldin CH, Moustakas A
Oncotarget 2018 Jan 19;9(5):5716-5735
Oncotarget 2018 Jan 19;9(5):5716-5735
Adiponectin release and insulin receptor targeting share trans-Golgi-dependent endosomal trafficking routes.
Rödiger M, Werno MW, Wilhelmi I, Baumeier C, Hesse D, Wettschureck N, Offermanns S, Song K, Krauß M, Schürmann A
Molecular metabolism 2018 Feb;8:167-179
Molecular metabolism 2018 Feb;8:167-179
Localization to detergent-resistant membranes and HIV-1 core entry inhibition correlate with HIV-1 restriction by SERINC5.
Schulte B, Selyutina A, Opp S, Herschhorn A, Sodroski JG, Pizzato M, Diaz-Griffero F
Virology 2018 Feb;515:52-65
Virology 2018 Feb;515:52-65
Clinical significance of interleukin‑6 and inducible nitric oxide synthase in ketamine‑induced cystitis.
Huang CJ, Lee FK, Chen SK, Chien CC, Wu ST, Wang YC
International journal of molecular medicine 2018 Feb;41(2):836-844
International journal of molecular medicine 2018 Feb;41(2):836-844
Dexamethasone-Mediated Upregulation of Calreticulin Inhibits Primary Human Glioblastoma Dispersal Ex Vivo.
Nair M, Romero J, Mahtabfar A, Meleis AM, Foty RA, Corbett SA
International journal of molecular sciences 2018 Feb 14;19(2)
International journal of molecular sciences 2018 Feb 14;19(2)
Human Adenovirus Infection Causes Cellular E3 Ubiquitin Ligase MKRN1 Degradation Involving the Viral Core Protein pVII.
Inturi R, Mun K, Singethan K, Schreiner S, Punga T
Journal of virology 2018 Feb 1;92(3)
Journal of virology 2018 Feb 1;92(3)
Elevated HuR in Pancreas Promotes a Pancreatitis-Like Inflammatory Microenvironment That Facilitates Tumor Development.
Peng W, Furuuchi N, Aslanukova L, Huang YH, Brown SZ, Jiang W, Addya S, Vishwakarma V, Peters E, Brody JR, Dixon DA, Sawicki JA
Molecular and cellular biology 2018 Feb 1;38(3)
Molecular and cellular biology 2018 Feb 1;38(3)
Partial loss of psychiatric risk gene Mir137 in mice causes repetitive behavior and impairs sociability and learning via increased Pde10a.
Cheng Y, Wang ZM, Tan W, Wang X, Li Y, Bai B, Li Y, Zhang SF, Yan HL, Chen ZL, Liu CM, Mi TW, Xia S, Zhou Z, Liu A, Tang GB, Liu C, Dai ZJ, Wang YY, Wang H, Wang X, Kang Y, Lin L, Chen Z, Xie N, Sun Q, Xie W, Peng J, Chen D, Teng ZQ, Jin P
Nature neuroscience 2018 Dec;21(12):1689-1703
Nature neuroscience 2018 Dec;21(12):1689-1703
A novel probe to assess cytosolic entry of exogenous proteins.
Lu Q, Grotzke JE, Cresswell P
Nature communications 2018 Aug 6;9(1):3104
Nature communications 2018 Aug 6;9(1):3104
Acetylation state of RelA modulated by epigenetic drugs prolongs survival and induces a neuroprotective effect on ALS murine model.
Schiaffino L, Bonafede R, Scambi I, Parrella E, Pizzi M, Mariotti R
Scientific reports 2018 Aug 27;8(1):12875
Scientific reports 2018 Aug 27;8(1):12875
MicroRNA miR-509 Regulates ERK1/2, the Vimentin Network, and Focal Adhesions by Targeting Plk1.
Liao G, Wang R, Rezey AC, Gerlach BD, Tang DD
Scientific reports 2018 Aug 22;8(1):12635
Scientific reports 2018 Aug 22;8(1):12635
Gli3 controls the onset of cortical neurogenesis by regulating the radial glial cell cycle through Cdk6 expression.
Hasenpusch-Theil K, West S, Kelman A, Kozic Z, Horrocks S, McMahon AP, Price DJ, Mason JO, Theil T
Development (Cambridge, England) 2018 Aug 20;145(17)
Development (Cambridge, England) 2018 Aug 20;145(17)
Protein phosphatase 2A stimulates activation of TFEB and TFE3 transcription factors in response to oxidative stress.
Martina JA, Puertollano R
The Journal of biological chemistry 2018 Aug 10;293(32):12525-12534
The Journal of biological chemistry 2018 Aug 10;293(32):12525-12534
p110α of PI3K is necessary and sufficient for quiescence exit in adult muscle satellite cells.
Wang G, Zhu H, Situ C, Han L, Yu Y, Cheung TH, Liu K, Wu Z
The EMBO journal 2018 Apr 13;37(8)
The EMBO journal 2018 Apr 13;37(8)
Small Intestine Microbiota Regulate Host Digestive and Absorptive Adaptive Responses to Dietary Lipids.
Martinez-Guryn K, Hubert N, Frazier K, Urlass S, Musch MW, Ojeda P, Pierre JF, Miyoshi J, Sontag TJ, Cham CM, Reardon CA, Leone V, Chang EB
Cell host & microbe 2018 Apr 11;23(4):458-469.e5
Cell host & microbe 2018 Apr 11;23(4):458-469.e5
Elongator subunit 3 (ELP3) modifies ALS through tRNA modification.
Bento-Abreu A, Jager G, Swinnen B, Rué L, Hendrickx S, Jones A, Staats KA, Taes I, Eykens C, Nonneman A, Nuyts R, Timmers M, Silva L, Chariot A, Nguyen L, Ravits J, Lemmens R, Cabooter D, Van Den Bosch L, Van Damme P, Al-Chalabi A, Bystrom A, Robberecht W
Human molecular genetics 2018 Apr 1;27(7):1276-1289
Human molecular genetics 2018 Apr 1;27(7):1276-1289
Sirtuin 2 Regulates Microvascular Inflammation during Sepsis.
Buechler N, Wang X, Yoza BK, McCall CE, Vachharajani V
Journal of immunology research 2017;2017:2648946
Journal of immunology research 2017;2017:2648946
Inhibition of IRE1α-mediated XBP1 mRNA cleavage by XBP1 reveals a novel regulatory process during the unfolded protein response.
Chalmers F, van Lith M, Sweeney B, Cain K, Bulleid NJ
Wellcome open research 2017;2:36
Wellcome open research 2017;2:36
Sirt3 deficiency does not affect venous thrombosis or NETosis despite mild elevation of intracellular ROS in platelets and neutrophils in mice.
Hayashi H, Cherpokova D, Martinod K, Witsch T, Wong SL, Gallant M, Cifuni SM, Guarente LP, Wagner DD
PloS one 2017;12(12):e0188341
PloS one 2017;12(12):e0188341
The tumor suppressor phosphatase PP2A-B56α regulates stemness and promotes the initiation of malignancies in a novel murine model.
Janghorban M, Langer EM, Wang X, Zachman D, Daniel CJ, Hooper J, Fleming WH, Agarwal A, Sears RC
PloS one 2017;12(11):e0188910
PloS one 2017;12(11):e0188910
Heat shock proteins HSPB8 and DNAJC5B have HCV antiviral activity.
Braga ACS, Carneiro BM, Batista MN, Akinaga MM, Bittar C, Rahal P
PloS one 2017;12(11):e0188467
PloS one 2017;12(11):e0188467
FLNA is implicated in pulmonary neuroendocrine tumors aggressiveness and progression.
Vitali E, Boemi I, Rosso L, Cambiaghi V, Novellis P, Mantovani G, Spada A, Alloisio M, Veronesi G, Ferrero S, Lania AG
Oncotarget 2017 Sep 29;8(44):77330-77340
Oncotarget 2017 Sep 29;8(44):77330-77340
The catalytic subunit of DNA polymerase δ inhibits γTuRC activity and regulates Golgi-derived microtubules.
Shen Y, Liu P, Jiang T, Hu Y, Au FKC, Qi RZ
Nature communications 2017 Sep 15;8(1):554
Nature communications 2017 Sep 15;8(1):554
Cells lay their own tracks - optogenetic Cdc42 activation stimulates fibronectin deposition supporting directed migration.
Zimmerman SP, Asokan SB, Kuhlman B, Bear JE
Journal of cell science 2017 Sep 15;130(18):2971-2983
Journal of cell science 2017 Sep 15;130(18):2971-2983
Deletion of Spata2 by CRISPR/Cas9n causes increased inhibin alpha expression and attenuated fertility in male mice.
Zhao J, Zhao J, Xu G, Wang Z, Gao J, Cui S, Liu J
Biology of reproduction 2017 Sep 1;97(3):497-513
Biology of reproduction 2017 Sep 1;97(3):497-513
Cardiac troponin T and fast skeletal muscle denervation in ageing.
Xu Z, Feng X, Dong J, Wang ZM, Lee J, Furdui C, Files DC, Beavers KM, Kritchevsky S, Milligan C, Jin JP, Delbono O, Zhang T
Journal of cachexia, sarcopenia and muscle 2017 Oct;8(5):808-823
Journal of cachexia, sarcopenia and muscle 2017 Oct;8(5):808-823
Internally ratiometric fluorescent sensors for evaluation of intracellular GTP levels and distribution.
Bianchi-Smiraglia A, Rana MS, Foley CE, Paul LM, Lipchick BC, Moparthy S, Moparthy K, Fink EE, Bagati A, Hurley E, Affronti HC, Bakin AV, Kandel ES, Smiraglia DJ, Feltri ML, Sousa R, Nikiforov MA
Nature methods 2017 Oct;14(10):1003-1009
Nature methods 2017 Oct;14(10):1003-1009
Data-Modeling Identifies Conflicting Signaling Axes Governing Myoblast Proliferation and Differentiation Responses to Diverse Ligand Stimuli.
Loiben AM, Soueid-Baumgarten S, Kopyto RF, Bhattacharya D, Kim JC, Cosgrove BD
Cellular and molecular bioengineering 2017 Oct;10(5):433-450
Cellular and molecular bioengineering 2017 Oct;10(5):433-450
Cytoplasmic cyclin D1 controls the migration and invasiveness of mantle lymphoma cells.
Body S, Esteve-Arenys A, Miloudi H, Recasens-Zorzo C, Tchakarska G, Moros A, Bustany S, Vidal-Crespo A, Rodriguez V, Lavigne R, Com E, Casanova I, Mangues R, Weigert O, Sanjuan-Pla A, Menéndez P, Marcq B, Picquenot JM, Pérez-Galán P, Jardin F, Roué G, Sola B
Scientific reports 2017 Oct 24;7(1):13946
Scientific reports 2017 Oct 24;7(1):13946
VPS18 recruits VPS41 to the human HOPS complex via a RING-RING interaction.
Hunter MR, Scourfield EJ, Emmott E, Graham SC
The Biochemical journal 2017 Oct 23;474(21):3615-3626
The Biochemical journal 2017 Oct 23;474(21):3615-3626
Stabilization of dynamic microtubules by mDia1 drives Tau-dependent Aβ(1-42) synaptotoxicity.
Qu X, Yuan FN, Corona C, Pasini S, Pero ME, Gundersen GG, Shelanski ML, Bartolini F
The Journal of cell biology 2017 Oct 2;216(10):3161-3178
The Journal of cell biology 2017 Oct 2;216(10):3161-3178
A Detailed Protocol for Subcellular RNA Sequencing (subRNA-seq).
Mayer A, Churchman LS
Current protocols in molecular biology 2017 Oct 2;120:4.29.1-4.29.18
Current protocols in molecular biology 2017 Oct 2;120:4.29.1-4.29.18
Cinacalcet corrects hypercalcemia in mice with an inactivating Gα11 mutation.
Howles SA, Hannan FM, Gorvin CM, Piret SE, Paudyal A, Stewart M, Hough TA, Nesbit MA, Wells S, Brown SD, Cox RD, Thakker RV
JCI insight 2017 Oct 19;2(20)
JCI insight 2017 Oct 19;2(20)
Histone isoform H2A1H promotes attainment of distinct physiological states by altering chromatin dynamics.
Bhattacharya S, Reddy D, Jani V, Gadewal N, Shah S, Reddy R, Bose K, Sonavane U, Joshi R, Smoot D, Ashktorab H, Gupta S
Epigenetics & chromatin 2017 Oct 18;10(1):48
Epigenetics & chromatin 2017 Oct 18;10(1):48
Deletion of β1-integrin in collecting duct principal cells leads to tubular injury and renal medullary fibrosis.
Mamuya FA, Xie D, Lei L, Huang M, Tsuji K, Capen DE, Yang B, Weissleder R, Păunescu TG, Lu HAJ
American journal of physiology. Renal physiology 2017 Oct 1;313(4):F1026-F1037
American journal of physiology. Renal physiology 2017 Oct 1;313(4):F1026-F1037
FGF21 improves glucose homeostasis in an obese diabetes-prone mouse model independent of body fat changes.
Laeger T, Baumeier C, Wilhelmi I, Würfel J, Kamitz A, Schürmann A
Diabetologia 2017 Nov;60(11):2274-2284
Diabetologia 2017 Nov;60(11):2274-2284
Mechanism and regulation of the Lys6-selective deubiquitinase USP30.
Gersch M, Gladkova C, Schubert AF, Michel MA, Maslen S, Komander D
Nature structural & molecular biology 2017 Nov;24(11):920-930
Nature structural & molecular biology 2017 Nov;24(11):920-930
Class I HDACs control a JIP1-dependent pathway for kinesin-microtubule binding in cardiomyocytes.
Blakeslee WW, Lin YH, Stratton MS, Tatman PD, Hu T, Ferguson BS, McKinsey TA
Journal of molecular and cellular cardiology 2017 Nov;112:74-82
Journal of molecular and cellular cardiology 2017 Nov;112:74-82
Regulation of epithelial-mesenchymal transition and metastasis by TGF-β, P-bodies, and autophagy.
Hardy SD, Shinde A, Wang WH, Wendt MK, Geahlen RL
Oncotarget 2017 Nov 28;8(61):103302-103314
Oncotarget 2017 Nov 28;8(61):103302-103314
cFLIP critically modulates apoptotic resistance in epithelial-to-mesenchymal transition.
Padmanabhan C, Rellinger EJ, Zhu J, An H, Woodbury LG, Chung DH, Waterson AG, Lindsley CW, Means AL, Beauchamp RD
Oncotarget 2017 Nov 24;8(60):101072-101086
Oncotarget 2017 Nov 24;8(60):101072-101086
MYC regulates ductal-neuroendocrine lineage plasticity in pancreatic ductal adenocarcinoma associated with poor outcome and chemoresistance.
Farrell AS, Joly MM, Allen-Petersen BL, Worth PJ, Lanciault C, Sauer D, Link J, Pelz C, Heiser LM, Morton JP, Muthalagu N, Hoffman MT, Manning SL, Pratt ED, Kendsersky ND, Egbukichi N, Amery TS, Thoma MC, Jenny ZP, Rhim AD, Murphy DJ, Sansom OJ, Crawford HC, Sheppard BC, Sears RC
Nature communications 2017 Nov 23;8(1):1728
Nature communications 2017 Nov 23;8(1):1728
Structural and spatial chromatin features at developmental gene loci in human pluripotent stem cells.
Ikeda H, Sone M, Yamanaka S, Yamamoto T
Nature communications 2017 Nov 20;8(1):1616
Nature communications 2017 Nov 20;8(1):1616
Tumor-Suppressor Inactivation of GDF11 Occurs by Precursor Sequestration in Triple-Negative Breast Cancer.
Bajikar SS, Wang CC, Borten MA, Pereira EJ, Atkins KA, Janes KA
Developmental cell 2017 Nov 20;43(4):418-435.e13
Developmental cell 2017 Nov 20;43(4):418-435.e13
E-cadherin integrates mechanotransduction and EGFR signaling to control junctional tissue polarization and tight junction positioning.
Rübsam M, Mertz AF, Kubo A, Marg S, Jüngst C, Goranci-Buzhala G, Schauss AC, Horsley V, Dufresne ER, Moser M, Ziegler W, Amagai M, Wickström SA, Niessen CM
Nature communications 2017 Nov 1;8(1):1250
Nature communications 2017 Nov 1;8(1):1250
Nanoparticulate titanium dioxide-inhibited dendritic development is involved in apoptosis and autophagy of hippocampal neurons in offspring mice.
Zhou Y, Hong F, Tian Y, Zhao X, Hong J, Ze Y, Wang L
Toxicology research 2017 Nov 1;6(6):889-901
Toxicology research 2017 Nov 1;6(6):889-901
Metabolic, Reproductive, and Neurologic Abnormalities in Agpat1-Null Mice.
Agarwal AK, Tunison K, Dalal JS, Nagamma SS, Hamra FK, Sankella S, Shao X, Auchus RJ, Garg A
Endocrinology 2017 Nov 1;158(11):3954-3973
Endocrinology 2017 Nov 1;158(11):3954-3973
P21-activated kinase 1 regulates resistance to BRAF inhibition in human cancer cells.
Babagana M, Johnson S, Slabodkin H, Bshara W, Morrison C, Kandel ES
Molecular carcinogenesis 2017 May;56(5):1515-1525
Molecular carcinogenesis 2017 May;56(5):1515-1525
Detection of lower levels of SNAP25 using multiple microarray systems and its functional significance in medulloblastoma.
Huang CJ, Lee CL, Liu CY, Huang SH, Hou JW, Chen YH, Chien CC, Ho CM, Lo WC, Hung KL
International journal of molecular medicine 2017 May;39(5):1195-1205
International journal of molecular medicine 2017 May;39(5):1195-1205
A Molecular Switch Regulating Cell Fate Choice between Muscle Progenitor Cells and Brown Adipocytes.
An Y, Wang G, Diao Y, Long Y, Fu X, Weng M, Zhou L, Sun K, Cheung TH, Ip NY, Sun H, Wang H, Wu Z
Developmental cell 2017 May 22;41(4):382-391.e5
Developmental cell 2017 May 22;41(4):382-391.e5
Glycation potentiates α-synuclein-associated neurodegeneration in synucleinopathies.
Vicente Miranda H, Szego ÉM, Oliveira LMA, Breda C, Darendelioglu E, de Oliveira RM, Ferreira DG, Gomes MA, Rott R, Oliveira M, Munari F, Enguita FJ, Simões T, Rodrigues EF, Heinrich M, Martins IC, Zamolo I, Riess O, Cordeiro C, Ponces-Freire A, Lashuel HA, Santos NC, Lopes LV, Xiang W, Jovin TM, Penque D, Engelender S, Zweckstetter M, Klucken J, Giorgini F, Quintas A, Outeiro TF
Brain : a journal of neurology 2017 May 1;140(5):1399-1419
Brain : a journal of neurology 2017 May 1;140(5):1399-1419
Expression of N-WASP is regulated by HiF1α through the hypoxia response element in the N-WASP promoter.
Salvi A, Thanabalu T
Biochemistry and biophysics reports 2017 Mar;9:13-21
Biochemistry and biophysics reports 2017 Mar;9:13-21
Role of Fibulin 3 in Aging-Related Joint Changes and Osteoarthritis Pathogenesis in Human and Mouse Knee Cartilage.
Hasegawa A, Yonezawa T, Taniguchi N, Otabe K, Akasaki Y, Matsukawa T, Saito M, Neo M, Marmorstein LY, Lotz MK
Arthritis & rheumatology (Hoboken, N.J.) 2017 Mar;69(3):576-585
Arthritis & rheumatology (Hoboken, N.J.) 2017 Mar;69(3):576-585
Use of a novel docosahexaenoic acid formulation vs control in a neonatal porcine model of short bowel syndrome leads to greater intestinal absorption and higher systemic levels of DHA.
Martin CR, Stoll B, Cluette-Brown J, Akinkuotu AC, Olutoye OO, Gura KM, Singh P, Zaman MM, Perillo MC, Puder M, Freedman SD, Burrin D
Nutrition research (New York, N.Y.) 2017 Mar;39:51-60
Nutrition research (New York, N.Y.) 2017 Mar;39:51-60
Tenascin-C Is a Major Component of the Fibrogenic Niche in Kidney Fibrosis.
Fu H, Tian Y, Zhou L, Zhou D, Tan RJ, Stolz DB, Liu Y
Journal of the American Society of Nephrology : JASN 2017 Mar;28(3):785-801
Journal of the American Society of Nephrology : JASN 2017 Mar;28(3):785-801
The mechanism of sirtuin 2-mediated exacerbation of alpha-synuclein toxicity in models of Parkinson disease.
de Oliveira RM, Vicente Miranda H, Francelle L, Pinho R, Szegö ÉM, Martinho R, Munari F, Lázaro DF, Moniot S, Guerreiro P, Fonseca-Ornelas L, Marijanovic Z, Antas P, Gerhardt E, Enguita FJ, Fauvet B, Penque D, Pais TF, Tong Q, Becker S, Kügler S, Lashuel HA, Steegborn C, Zweckstetter M, Outeiro TF
PLoS biology 2017 Mar;15(3):e2000374
PLoS biology 2017 Mar;15(3):e2000374
PJA2 ubiquitinates the HIV-1 Tat protein with atypical chain linkages to activate viral transcription.
Faust TB, Li Y, Jang GM, Johnson JR, Yang S, Weiss A, Krogan NJ, Frankel AD
Scientific reports 2017 Mar 27;7:45394
Scientific reports 2017 Mar 27;7:45394
Cross-Presentation of Soluble and Cell-Associated Antigen by Murine Hepatocytes Is Enhanced by Collectrin Expression.
Dolina JS, Cechova S, Rudy CK, Sung SJ, Tang WW, Lee J, Hahn YS, Le TH
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2341-2351
Journal of immunology (Baltimore, Md. : 1950) 2017 Mar 15;198(6):2341-2351
Integrated Molecular Characterization of Uterine Carcinosarcoma.
Cherniack AD, Shen H, Walter V, Stewart C, Murray BA, Bowlby R, Hu X, Ling S, Soslow RA, Broaddus RR, Zuna RE, Robertson G, Laird PW, Kucherlapati R, Mills GB, Cancer Genome Atlas Research Network, Weinstein JN, Zhang J, Akbani R, Levine DA
Cancer cell 2017 Mar 13;31(3):411-423
Cancer cell 2017 Mar 13;31(3):411-423
Dysregulated circadian rhythm pathway in human osteoarthritis: NR1D1 and BMAL1 suppression alters TGF-β signaling in chondrocytes.
Akagi R, Akatsu Y, Fisch KM, Alvarez-Garcia O, Teramura T, Muramatsu Y, Saito M, Sasho T, Su AI, Lotz MK
Osteoarthritis and cartilage 2017 Jun;25(6):943-951
Osteoarthritis and cartilage 2017 Jun;25(6):943-951
Host DNA released by NETosis promotes rhinovirus-induced type-2 allergic asthma exacerbation.
Toussaint M, Jackson DJ, Swieboda D, Guedán A, Tsourouktsoglou TD, Ching YM, Radermecker C, Makrinioti H, Aniscenko J, Bartlett NW, Edwards MR, Solari R, Farnir F, Papayannopoulos V, Bureau F, Marichal T, Johnston SL
Nature medicine 2017 Jun;23(6):681-691
Nature medicine 2017 Jun;23(6):681-691
Proteasome Activation by Small Molecules.
Leestemaker Y, de Jong A, Witting KF, Penning R, Schuurman K, Rodenko B, Zaal EA, van de Kooij B, Laufer S, Heck AJR, Borst J, Scheper W, Berkers CR, Ovaa H
Cell chemical biology 2017 Jun 22;24(6):725-736.e7
Cell chemical biology 2017 Jun 22;24(6):725-736.e7
DOT1L safeguards cartilage homeostasis and protects against osteoarthritis.
Monteagudo S, Cornelis FMF, Aznar-Lopez C, Yibmantasiri P, Guns LA, Carmeliet P, Cailotto F, Lories RJ
Nature communications 2017 Jun 19;8:15889
Nature communications 2017 Jun 19;8:15889
PLK4 phosphorylation of CP110 is required for efficient centriole assembly.
Lee M, Seo MY, Chang J, Hwang DS, Rhee K
Cell cycle (Georgetown, Tex.) 2017 Jun 18;16(12):1225-1234
Cell cycle (Georgetown, Tex.) 2017 Jun 18;16(12):1225-1234
Endogenous AJAP1 associates with the cytoskeleton and attenuates angiogenesis in endothelial cells.
Hötte K, Smyrek I, Starzinski-Powitz A, Stelzer EHK
Biology open 2017 Jun 15;6(6):723-731
Biology open 2017 Jun 15;6(6):723-731
Cell-specific expression of aquaporin-5 (Aqp5) in alveolar epithelium is directed by GATA6/Sp1 via histone acetylation.
Flodby P, Li C, Liu Y, Wang H, Rieger ME, Minoo P, Crandall ED, Ann DK, Borok Z, Zhou B
Scientific reports 2017 Jun 14;7(1):3473
Scientific reports 2017 Jun 14;7(1):3473
A Herpesviral Immediate Early Protein Promotes Transcription Elongation of Viral Transcripts.
Fox HL, Dembowski JA, DeLuca NA
mBio 2017 Jun 13;8(3)
mBio 2017 Jun 13;8(3)
MiRNA-143 mediates the proliferative signaling pathway of FSH and regulates estradiol production.
Zhang L, Zhang X, Zhang X, Lu Y, Li L, Cui S
The Journal of endocrinology 2017 Jul;234(1):1-14
The Journal of endocrinology 2017 Jul;234(1):1-14
Roles of the PDZ-binding motif of HPV 16 E6 protein in oncogenic transformation of human cervical keratinocytes.
Yoshimatsu Y, Nakahara T, Tanaka K, Inagawa Y, Narisawa-Saito M, Yugawa T, Ohno SI, Fujita M, Nakagama H, Kiyono T
Cancer science 2017 Jul;108(7):1303-1309
Cancer science 2017 Jul;108(7):1303-1309
Lack of Glycogenin Causes Glycogen Accumulation and Muscle Function Impairment.
Testoni G, Duran J, García-Rocha M, Vilaplana F, Serrano AL, Sebastián D, López-Soldado I, Sullivan MA, Slebe F, Vilaseca M, Muñoz-Cánoves P, Guinovart JJ
Cell metabolism 2017 Jul 5;26(1):256-266.e4
Cell metabolism 2017 Jul 5;26(1):256-266.e4
BAIAP3, a C2 domain-containing Munc13 protein, controls the fate of dense-core vesicles in neuroendocrine cells.
Zhang X, Jiang S, Mitok KA, Li L, Attie AD, Martin TFJ
The Journal of cell biology 2017 Jul 3;216(7):2151-2166
The Journal of cell biology 2017 Jul 3;216(7):2151-2166
A Novel α-Calcitonin Gene-Related Peptide Analogue Protects Against End-Organ Damage in Experimental Hypertension, Cardiac Hypertrophy, and Heart Failure.
Aubdool AA, Thakore P, Argunhan F, Smillie SJ, Schnelle M, Srivastava S, Alawi KM, Wilde E, Mitchell J, Farrell-Dillon K, Richards DA, Maltese G, Siow RC, Nandi M, Clark JE, Shah AM, Sams A, Brain SD
Circulation 2017 Jul 25;136(4):367-383
Circulation 2017 Jul 25;136(4):367-383
Short-chain fatty acids and inulin, but not guar gum, prevent diet-induced obesity and insulin resistance through differential mechanisms in mice.
Weitkunat K, Stuhlmann C, Postel A, Rumberger S, Fankhänel M, Woting A, Petzke KJ, Gohlke S, Schulz TJ, Blaut M, Klaus S, Schumann S
Scientific reports 2017 Jul 21;7(1):6109
Scientific reports 2017 Jul 21;7(1):6109
TDP-43 Depletion in Microglia Promotes Amyloid Clearance but Also Induces Synapse Loss.
Paolicelli RC, Jawaid A, Henstridge CM, Valeri A, Merlini M, Robinson JL, Lee EB, Rose J, Appel S, Lee VM, Trojanowski JQ, Spires-Jones T, Schulz PE, Rajendran L
Neuron 2017 Jul 19;95(2):297-308.e6
Neuron 2017 Jul 19;95(2):297-308.e6
Fat mass and obesity-associated (FTO) protein regulates adult neurogenesis.
Li L, Zang L, Zhang F, Chen J, Shen H, Shu L, Liang F, Feng C, Chen D, Tao H, Xu T, Li Z, Kang Y, Wu H, Tang L, Zhang P, Jin P, Shu Q, Li X
Human molecular genetics 2017 Jul 1;26(13):2398-2411
Human molecular genetics 2017 Jul 1;26(13):2398-2411
Rab28 is a TBC1D1/TBC1D4 substrate involved in GLUT4 trafficking.
Zhou Z, Menzel F, Benninghoff T, Chadt A, Du C, Holman GD, Al-Hasani H
FEBS letters 2017 Jan;591(1):88-96
FEBS letters 2017 Jan;591(1):88-96
Progeroid syndrome patients with ZMPSTE24 deficiency could benefit when treated with rapamycin and dimethylsulfoxide.
Akinci B, Sankella S, Gilpin C, Ozono K, Garg A, Agarwal AK
Cold Spring Harbor molecular case studies 2017 Jan;3(1):a001339
Cold Spring Harbor molecular case studies 2017 Jan;3(1):a001339
Hepatic Stellate Cell Selective Disruption of Dynamin-2 GTPase Increases Murine Fibrogenesis through Up-Regulation of Sphingosine-1 Phosphate-Induced Cell Migration.
Wang R, Ding Q, De Assuncao TM, Mounajjed T, Maiers JL, Dou C, Cao S, Yaqoob U, Huebert RC, Shah VH
The American journal of pathology 2017 Jan;187(1):134-145
The American journal of pathology 2017 Jan;187(1):134-145
RIP3 antagonizes a TSC2-mediated pro-survival pathway in glioblastoma cell death.
Fettweis G, Di Valentin E, L'homme L, Lassence C, Dequiedt F, Fillet M, Coupienne I, Piette J
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):113-124
Biochimica et biophysica acta. Molecular cell research 2017 Jan;1864(1):113-124
AMP-activated kinase and the endogenous endocannabinoid system might contribute to antinociceptive effects of prolonged moderate caloric restriction in mice.
King-Himmelreich TS, Möser CV, Wolters MC, Schmetzer J, Möller M, Schreiber Y, Ferreirós N, Geisslinger G, Niederberger E
Molecular pain 2017 Jan;13:1744806917703111
Molecular pain 2017 Jan;13:1744806917703111
Microphthalmia-associated transcription factor suppresses invasion by reducing intracellular GTP pools.
Bianchi-Smiraglia A, Bagati A, Fink EE, Moparthy S, Wawrzyniak JA, Marvin EK, Battaglia S, Jowdy P, Kolesnikova M, Foley CE, Berman AE, Kozlova NI, Lipchick BC, Paul-Rosner LM, Bshara W, Ackroyd JJ, Shewach DS, Nikiforov MA
Oncogene 2017 Jan 5;36(1):84-96
Oncogene 2017 Jan 5;36(1):84-96
A Highly Active Isoform of Lentivirus Restriction Factor SAMHD1 in Mouse.
Bloch N, Gläsker S, Sitaram P, Hofmann H, Shepard CN, Schultz ML, Kim B, Landau NR
The Journal of biological chemistry 2017 Jan 20;292(3):1068-1080
The Journal of biological chemistry 2017 Jan 20;292(3):1068-1080
Lamina-associated polypeptide 1 is dispensable for embryonic myogenesis but required for postnatal skeletal muscle growth.
Shin JY, Méndez-López I, Hong M, Wang Y, Tanji K, Wu W, Shugol L, Krauss RS, Dauer WT, Worman HJ
Human molecular genetics 2017 Jan 1;26(1):65-78
Human molecular genetics 2017 Jan 1;26(1):65-78
Immunogenic Dendritic Cell Generation from Pluripotent Stem Cells by Ectopic Expression of Runx3.
Takacs E, Boto P, Simo E, Csuth TI, Toth BM, Raveh-Amit H, Pap A, Kovács EG, Kobolak J, Benkö S, Dinnyes A, Szatmari I
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):239-248
Journal of immunology (Baltimore, Md. : 1950) 2017 Jan 1;198(1):239-248
Polyubiquitination of apurinic/apyrimidinic endonuclease 1 by Parkin.
Scott TL, Wicker CA, Suganya R, Dhar B, Pittman T, Horbinski C, Izumi T
Molecular carcinogenesis 2017 Feb;56(2):325-336
Molecular carcinogenesis 2017 Feb;56(2):325-336
Gα(11) mutation in mice causes hypocalcemia rectifiable by calcilytic therapy.
Gorvin CM, Hannan FM, Howles SA, Babinsky VN, Piret SE, Rogers A, Freidin AJ, Stewart M, Paudyal A, Hough TA, Nesbit MA, Wells S, Vincent TL, Brown SD, Cox RD, Thakker RV
JCI insight 2017 Feb 9;2(3):e91103
JCI insight 2017 Feb 9;2(3):e91103
Sex-Dependent Regulation of Aromatase-Mediated Synaptic Plasticity in the Basolateral Amygdala.
Bender RA, Zhou L, Vierk R, Brandt N, Keller A, Gee CE, Schäfer MK, Rune GM
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Feb 8;37(6):1532-1545
The Journal of neuroscience : the official journal of the Society for Neuroscience 2017 Feb 8;37(6):1532-1545
Epilepsy-associated GRIN2A mutations reduce NMDA receptor trafficking and agonist potency - molecular profiling and functional rescue.
Addis L, Virdee JK, Vidler LR, Collier DA, Pal DK, Ursu D
Scientific reports 2017 Feb 27;7(1):66
Scientific reports 2017 Feb 27;7(1):66
Cytoplasmic poly-GA aggregates impair nuclear import of TDP-43 in C9orf72 ALS/FTLD.
Khosravi B, Hartmann H, May S, Möhl C, Ederle H, Michaelsen M, Schludi MH, Dormann D, Edbauer D
Human molecular genetics 2017 Feb 15;26(4):790-800
Human molecular genetics 2017 Feb 15;26(4):790-800
Pervasive translational regulation of the cell signalling circuitry underlies mammalian development.
Fujii K, Shi Z, Zhulyn O, Denans N, Barna M
Nature communications 2017 Feb 14;8:14443
Nature communications 2017 Feb 14;8:14443
Phosphorylation of transcriptional regulators in the retinoblastoma protein pathway by UL97, the viral cyclin-dependent kinase encoded by human cytomegalovirus.
Iwahori S, Kalejta RF
Virology 2017 Dec;512:95-103
Virology 2017 Dec;512:95-103
NLRX1 promotes immediate IRF1-directed antiviral responses by limiting dsRNA-activated translational inhibition mediated by PKR.
Feng H, Lenarcic EM, Yamane D, Wauthier E, Mo J, Guo H, McGivern DR, González-López O, Misumi I, Reid LM, Whitmire JK, Ting JP, Duncan JA, Moorman NJ, Lemon SM
Nature immunology 2017 Dec;18(12):1299-1309
Nature immunology 2017 Dec;18(12):1299-1309
Modulation of BCR Signaling by the Induced Dimerization of Receptor-Associated SYK.
Westbroek ML, Geahlen RL
Antibodies (Basel, Switzerland) 2017 Dec 7;6(4)
Antibodies (Basel, Switzerland) 2017 Dec 7;6(4)
Inhibition of PIP4Kγ ameliorates the pathological effects of mutant huntingtin protein.
Al-Ramahi I, Giridharan SSP, Chen YC, Patnaik S, Safren N, Hasegawa J, de Haro M, Wagner Gee AK, Titus SA, Jeong H, Clarke J, Krainc D, Zheng W, Irvine RF, Barmada S, Ferrer M, Southall N, Weisman LS, Botas J, Marugan JJ
eLife 2017 Dec 26;6
eLife 2017 Dec 26;6
RhoC regulates the actin remodeling required for phagosome formation during FcγR-mediated phagocytosis.
Egami Y, Kawai K, Araki N
Journal of cell science 2017 Dec 15;130(24):4168-4179
Journal of cell science 2017 Dec 15;130(24):4168-4179
The neuroprotective agent Rasagiline mesylate attenuates cardiac remodeling after experimental myocardial infarction.
Varela A, Mavroidis M, Katsimpoulas M, Sfiroera I, Kappa N, Mesa A, Kostomitsopoulos NG, Cokkinos DV
ESC heart failure 2017 Aug;4(3):331-340
ESC heart failure 2017 Aug;4(3):331-340
Overexpression of Thioredoxin1 enhances functional recovery in a mouse model of hind limb ischemia.
Shaikh IA, Rishi MT, Youssef M, Selvaraju V, Thirunavukkarasu M, Ukani G, Lakshmanan R, Palesty JA, Maulik N
The Journal of surgical research 2017 Aug;216:158-168
The Journal of surgical research 2017 Aug;216:158-168
Sonic hedgehog signalling mediates astrocyte crosstalk with neurons to confer neuroprotection.
Ugbode CI, Smith I, Whalley BJ, Hirst WD, Rattray M
Journal of neurochemistry 2017 Aug;142(3):429-443
Journal of neurochemistry 2017 Aug;142(3):429-443
A Short Region of Connexin43 Reduces Human Glioma Stem Cell Migration, Invasion, and Survival through Src, PTEN, and FAK.
Jaraíz-Rodríguez M, Tabernero MD, González-Tablas M, Otero A, Orfao A, Medina JM, Tabernero A
Stem cell reports 2017 Aug 8;9(2):451-463
Stem cell reports 2017 Aug 8;9(2):451-463
The helicase, DDX3X, interacts with poly(A)-binding protein 1 (PABP1) and caprin-1 at the leading edge of migrating fibroblasts and is required for efficient cell spreading.
Copsey AC, Cooper S, Parker R, Lineham E, Lapworth C, Jallad D, Sweet S, Morley SJ
The Biochemical journal 2017 Aug 30;474(18):3109-3120
The Biochemical journal 2017 Aug 30;474(18):3109-3120
Accumulation of autophagosomes confers cytotoxicity.
Button RW, Roberts SL, Willis TL, Hanemann CO, Luo S
The Journal of biological chemistry 2017 Aug 18;292(33):13599-13614
The Journal of biological chemistry 2017 Aug 18;292(33):13599-13614
The C Terminus of the Herpes Simplex Virus UL25 Protein Is Required for Release of Viral Genomes from Capsids Bound to Nuclear Pores.
Huffman JB, Daniel GR, Falck-Pedersen E, Huet A, Smith GA, Conway JF, Homa FL
Journal of virology 2017 Aug 1;91(15)
Journal of virology 2017 Aug 1;91(15)
Effect of PPAR-β/δ agonist GW0742 treatment in the acute phase response and blood-brain barrier permeability following brain injury.
Chehaibi K, le Maire L, Bradoni S, Escola JC, Blanco-Vaca F, Slimane MN
Translational research : the journal of laboratory and clinical medicine 2017 Apr;182:27-48
Translational research : the journal of laboratory and clinical medicine 2017 Apr;182:27-48
Profiling Subcellular Protein Phosphatase Responses to Coxsackievirus B3 Infection of Cardiomyocytes.
Shah M, Smolko CM, Kinicki S, Chapman ZD, Brautigan DL, Janes KA
Molecular & cellular proteomics : MCP 2017 Apr;16(4 suppl 1):S244-S262
Molecular & cellular proteomics : MCP 2017 Apr;16(4 suppl 1):S244-S262
Development of Improved HDAC6 Inhibitors as Pharmacological Therapy for Axonal Charcot-Marie-Tooth Disease.
Benoy V, Vanden Berghe P, Jarpe M, Van Damme P, Robberecht W, Van Den Bosch L
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):417-428
Neurotherapeutics : the journal of the American Society for Experimental NeuroTherapeutics 2017 Apr;14(2):417-428
The Retromer Supports AMPA Receptor Trafficking During LTP.
Temkin P, Morishita W, Goswami D, Arendt K, Chen L, Malenka R
Neuron 2017 Apr 5;94(1):74-82.e5
Neuron 2017 Apr 5;94(1):74-82.e5
Human cytomegalovirus-encoded viral cyclin-dependent kinase (v-CDK) UL97 phosphorylates and inactivates the retinoblastoma protein-related p107 and p130 proteins.
Iwahori S, Umaña AC, VanDeusen HR, Kalejta RF
The Journal of biological chemistry 2017 Apr 21;292(16):6583-6599
The Journal of biological chemistry 2017 Apr 21;292(16):6583-6599
Synergic Functions of miRNAs Determine Neuronal Fate of Adult Neural Stem Cells.
Pons-Espinal M, de Luca E, Marzi MJ, Beckervordersandforth R, Armirotti A, Nicassio F, Fabel K, Kempermann G, De Pietri Tonelli D
Stem cell reports 2017 Apr 11;8(4):1046-1061
Stem cell reports 2017 Apr 11;8(4):1046-1061
Cancer Cells with Alternative Lengthening of Telomeres Do Not Display a General Hypersensitivity to ATR Inhibition.
Deeg KI, Chung I, Bauer C, Rippe K
Frontiers in oncology 2016;6:186
Frontiers in oncology 2016;6:186
Analysis of Epithelial-Mesenchymal Transition Induced by Transforming Growth Factor β.
Valcourt U, Carthy J, Okita Y, Alcaraz L, Kato M, Thuault S, Bartholin L, Moustakas A
Methods in molecular biology (Clifton, N.J.) 2016;1344:147-81
Methods in molecular biology (Clifton, N.J.) 2016;1344:147-81
Interactions of exercise training and high-fat diet on adiponectin forms and muscle receptors in mice.
Pierard M, Conotte S, Tassin A, Boutry S, Uzureau P, Boudjeltia KZ, Legrand A
Nutrition & metabolism 2016;13:75
Nutrition & metabolism 2016;13:75
Disease Phenotypes in a Mouse Model of RNA Toxicity Are Independent of Protein Kinase Cα and Protein Kinase Cβ.
Kim YK, Yadava RS, Mandal M, Mahadevan K, Yu Q, Leitges M, Mahadevan MS
PloS one 2016;11(9):e0163325
PloS one 2016;11(9):e0163325
Sirtuin-2 Regulates Sepsis Inflammation in ob/ob Mice.
Wang X, Buechler NL, Martin A, Wells J, Yoza B, McCall CE, Vachharajani V
PloS one 2016;11(8):e0160431
PloS one 2016;11(8):e0160431
Notch Signaling Activates Stem Cell Properties of Müller Glia through Transcriptional Regulation and Skp2-mediated Degradation of p27Kip1.
Del Debbio CB, Mir Q, Parameswaran S, Mathews S, Xia X, Zheng L, Neville AJ, Ahmad I
PloS one 2016;11(3):e0152025
PloS one 2016;11(3):e0152025
The Oncoprotein BRD4-NUT Generates Aberrant Histone Modification Patterns.
Zee BM, Dibona AB, Alekseyenko AA, French CA, Kuroda MI
PloS one 2016;11(10):e0163820
PloS one 2016;11(10):e0163820
Knockout Mice Reveal a Major Role for Alveolar Epithelial Type I Cells in Alveolar Fluid Clearance.
Flodby P, Kim YH, Beard LL, Gao D, Ji Y, Kage H, Liebler JM, Minoo P, Kim KJ, Borok Z, Crandall ED
American journal of respiratory cell and molecular biology 2016 Sep;55(3):395-406
American journal of respiratory cell and molecular biology 2016 Sep;55(3):395-406
Overexpression of the short endoglin isoform reduces renal fibrosis and inflammation after unilateral ureteral obstruction.
Muñoz-Félix JM, Pérez-Roque L, Núñez-Gómez E, Oujo B, Arévalo M, Ruiz-Remolina L, Cuesta C, Langa C, Pérez-Barriocanal F, Bernabeu C, Lopez-Novoa JM
Biochimica et biophysica acta 2016 Sep;1862(9):1801-14
Biochimica et biophysica acta 2016 Sep;1862(9):1801-14
Cellular effects induced by 17-β-estradiol to reduce the survival of renal cell carcinoma cells.
Wu ST, Ku WC, Huang CJ, Wang YC, Lin CM, Chen SK
Journal of biomedical science 2016 Sep 29;23(1):67
Journal of biomedical science 2016 Sep 29;23(1):67
Phosphorylation-dependent cleavage regulates von Hippel Lindau proteostasis and function.
German P, Bai S, Liu XD, Sun M, Zhou L, Kalra S, Zhang X, Minelli R, Scott KL, Mills GB, Jonasch E, Ding Z
Oncogene 2016 Sep 22;35(38):4973-80
Oncogene 2016 Sep 22;35(38):4973-80
Sp1 downregulates proinflammatory cytokine‑induced catabolic gene expression in nucleus pulposus cells.
Xu K, Wang X, Zhang Q, Liang A, Zhu H, Huang D, Li C, Ye W
Molecular medicine reports 2016 Oct;14(4):3961-8
Molecular medicine reports 2016 Oct;14(4):3961-8
Peroxisome Proliferator-activated Receptor-γ Activation Augments the β-Cell Unfolded Protein Response and Rescues Early Glycemic Deterioration and β Cell Death in Non-obese Diabetic Mice.
Maganti AV, Tersey SA, Syed F, Nelson JB, Colvin SC, Maier B, Mirmira RG
The Journal of biological chemistry 2016 Oct 21;291(43):22524-22533
The Journal of biological chemistry 2016 Oct 21;291(43):22524-22533
Rickettsia Sca4 Reduces Vinculin-Mediated Intercellular Tension to Promote Spread.
Lamason RL, Bastounis E, Kafai NM, Serrano R, Del Álamo JC, Theriot JA, Welch MD
Cell 2016 Oct 20;167(3):670-683.e10
Cell 2016 Oct 20;167(3):670-683.e10
Long and Short Isoforms of the Human Cytomegalovirus UL138 Protein Silence IE Transcription and Promote Latency.
Lee SH, Caviness K, Albright ER, Lee JH, Gelbmann CB, Rak M, Goodrum F, Kalejta RF
Journal of virology 2016 Oct 15;90(20):9483-94
Journal of virology 2016 Oct 15;90(20):9483-94
Desmin and αB-crystallin interplay in the maintenance of mitochondrial homeostasis and cardiomyocyte survival.
Diokmetzidou A, Soumaka E, Kloukina I, Tsikitis M, Makridakis M, Varela A, Davos CH, Georgopoulos S, Anesti V, Vlahou A, Capetanaki Y
Journal of cell science 2016 Oct 15;129(20):3705-3720
Journal of cell science 2016 Oct 15;129(20):3705-3720
Inhibition of the Biosynthesis of Prostaglandin E2 By Low-Dose Aspirin: Implications for Adenocarcinoma Metastasis.
Boutaud O, Sosa IR, Amin T, Oram D, Adler D, Hwang HS, Crews BC, Milne G, Harris BK, Hoeksema M, Knollmann BC, Lammers PE, Marnett LJ, Massion PP, Oates JA
Cancer prevention research (Philadelphia, Pa.) 2016 Nov;9(11):855-865
Cancer prevention research (Philadelphia, Pa.) 2016 Nov;9(11):855-865
Polo-like Kinase 1 Regulates Vimentin Phosphorylation at Ser-56 and Contraction in Smooth Muscle.
Li J, Wang R, Gannon OJ, Rezey AC, Jiang S, Gerlach BD, Liao G, Tang DD
The Journal of biological chemistry 2016 Nov 4;291(45):23693-23703
The Journal of biological chemistry 2016 Nov 4;291(45):23693-23703
Macrophage PPARγ, a Lipid Activated Transcription Factor Controls the Growth Factor GDF3 and Skeletal Muscle Regeneration.
Varga T, Mounier R, Patsalos A, Gogolák P, Peloquin M, Horvath A, Pap A, Daniel B, Nagy G, Pintye E, Póliska S, Cuvellier S, Larbi SB, Sansbury BE, Spite M, Brown CW, Chazaud B, Nagy L
Immunity 2016 Nov 15;45(5):1038-1051
Immunity 2016 Nov 15;45(5):1038-1051
Inositol-Triphosphate 3-Kinase C Mediates Inflammasome Activation and Treatment Response in Kawasaki Disease.
Alphonse MP, Duong TT, Shumitzu C, Hoang TL, McCrindle BW, Franco A, Schurmans S, Philpott DJ, Hibberd ML, Burns J, Kuijpers TW, Yeung RS
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 1;197(9):3481-3489
Journal of immunology (Baltimore, Md. : 1950) 2016 Nov 1;197(9):3481-3489
PIAS1 binds p300 and behaves as a coactivator or corepressor of the transcription factor c-Myb dependent on SUMO-status.
Ledsaak M, Bengtsen M, Molværsmyr AK, Fuglerud BM, Matre V, Eskeland R, Gabrielsen OS
Biochimica et biophysica acta 2016 May;1859(5):705-18
Biochimica et biophysica acta 2016 May;1859(5):705-18
Mutations in the Na(+)/citrate cotransporter NaCT (SLC13A5) in pediatric patients with epilepsy and developmental delay.
Klotz J, Porter BE, Colas C, Schlessinger A, Pajor AM
Molecular medicine (Cambridge, Mass.) 2016 May 26;22:310-21
Molecular medicine (Cambridge, Mass.) 2016 May 26;22:310-21
A Novel Crizotinib-Resistant Solvent-Front Mutation Responsive to Cabozantinib Therapy in a Patient with ROS1-Rearranged Lung Cancer.
Drilon A, Somwar R, Wagner JP, Vellore NA, Eide CA, Zabriskie MS, Arcila ME, Hechtman JF, Wang L, Smith RS, Kris MG, Riely GJ, Druker BJ, O'Hare T, Ladanyi M, Davare MA
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 May 15;22(10):2351-8
Clinical cancer research : an official journal of the American Association for Cancer Research 2016 May 15;22(10):2351-8
A mutation abolishing the ZMPSTE24 cleavage site in prelamin A causes a progeroid disorder.
Wang Y, Lichter-Konecki U, Anyane-Yeboa K, Shaw JE, Lu JT, Östlund C, Shin JY, Clark LN, Gundersen GG, Nagy PL, Worman HJ
Journal of cell science 2016 May 15;129(10):1975-80
Journal of cell science 2016 May 15;129(10):1975-80
TRIM39 negatively regulates the NFκB-mediated signaling pathway through stabilization of Cactin.
Suzuki M, Watanabe M, Nakamaru Y, Takagi D, Takahashi H, Fukuda S, Hatakeyama S
Cellular and molecular life sciences : CMLS 2016 Mar;73(5):1085-101
Cellular and molecular life sciences : CMLS 2016 Mar;73(5):1085-101
Filamin-A is required to mediate SST2 effects in pancreatic neuroendocrine tumours.
Vitali E, Cambiaghi V, Zerbi A, Carnaghi C, Colombo P, Peverelli E, Spada A, Mantovani G, Lania AG
Endocrine-related cancer 2016 Mar;23(3):181-90
Endocrine-related cancer 2016 Mar;23(3):181-90
Novel subcellular localization of the DNA helicase Twinkle at the kinetochore complex during mitosis in neuronal-like progenitor cells.
Uittenbogaard M, Chiaramello A
Histochemistry and cell biology 2016 Mar;145(3):275-86
Histochemistry and cell biology 2016 Mar;145(3):275-86
SREBP2 Activation Induces Hepatic Long-chain Acyl-CoA Synthetase 1 (ACSL1) Expression in Vivo and in Vitro through a Sterol Regulatory Element (SRE) Motif of the ACSL1 C-promoter.
Singh AB, Kan CF, Dong B, Liu J
The Journal of biological chemistry 2016 Mar 4;291(10):5373-84
The Journal of biological chemistry 2016 Mar 4;291(10):5373-84
Identification of a novel interaction between corticotropin releasing hormone (Crh) and macroautophagy.
Giannogonas P, Apostolou A, Manousopoulou A, Theocharis S, Macari SA, Psarras S, Garbis SD, Pothoulakis C, Karalis KP
Scientific reports 2016 Mar 18;6:23342
Scientific reports 2016 Mar 18;6:23342
FNDC5 is produced in the stomach and associated to body composition.
Barja-Fernández S, Folgueira C, Castelao C, Al-Massadi O, Bravo SB, Garcia-Caballero T, Leis R, Pardo M, Casanueva FF, Seoane LM
Scientific reports 2016 Mar 10;6:23067
Scientific reports 2016 Mar 10;6:23067
Small Molecule Inhibitor of CBFβ-RUNX Binding for RUNX Transcription Factor Driven Cancers.
Illendula A, Gilmour J, Grembecka J, Tirumala VSS, Boulton A, Kuntimaddi A, Schmidt C, Wang L, Pulikkan JA, Zong H, Parlak M, Kuscu C, Pickin A, Zhou Y, Gao Y, Mishra L, Adli M, Castilla LH, Rajewski RA, Janes KA, Guzman ML, Bonifer C, Bushweller JH
EBioMedicine 2016 Jun;8:117-131
EBioMedicine 2016 Jun;8:117-131
Regulation of Bone Morphogenetic Protein Signaling by ADP-ribosylation.
Watanabe Y, Papoutsoglou P, Maturi V, Tsubakihara Y, Hottiger MO, Heldin CH, Moustakas A
The Journal of biological chemistry 2016 Jun 10;291(24):12706-12723
The Journal of biological chemistry 2016 Jun 10;291(24):12706-12723
ADAM10-Notch signaling governs the recruitment of ovarian pregranulosa cells and controls folliculogenesis in mice.
Feng L, Wang Y, Cai H, Sun G, Niu W, Xin Q, Tang X, Zhang J, Wang C, Zhang H, Xia G
Journal of cell science 2016 Jun 1;129(11):2202-12
Journal of cell science 2016 Jun 1;129(11):2202-12
Reducing premature KCC2 expression rescues seizure susceptibility and spine morphology in atypical febrile seizures.
Awad PN, Sanon NT, Chattopadhyaya B, Carriço JN, Ouardouz M, Gagné J, Duss S, Wolf D, Desgent S, Cancedda L, Carmant L, Di Cristo G
Neurobiology of disease 2016 Jul;91:10-20
Neurobiology of disease 2016 Jul;91:10-20
Upregulation of the growth arrest-specific-2 in recurrent colorectal cancers, and its susceptibility to chemotherapy in a model cell system.
Huang CJ, Lee CL, Yang SH, Chien CC, Huang CC, Yang RN, Chang CC
Biochimica et biophysica acta 2016 Jul;1862(7):1345-53
Biochimica et biophysica acta 2016 Jul;1862(7):1345-53
Knocking down of heat-shock protein 27 directs differentiation of functional glutamatergic neurons from placenta-derived multipotent cells.
Cheng YC, Huang CJ, Lee YJ, Tien LT, Ku WC, Chien R, Lee FK, Chien CC
Scientific reports 2016 Jul 22;6:30314
Scientific reports 2016 Jul 22;6:30314
Feline Calicivirus Infection Disrupts Assembly of Cytoplasmic Stress Granules and Induces G3BP1 Cleavage.
Humoud MN, Doyle N, Royall E, Willcocks MM, Sorgeloos F, van Kuppeveld F, Roberts LO, Goodfellow IG, Langereis MA, Locker N
Journal of virology 2016 Jul 15;90(14):6489-6501
Journal of virology 2016 Jul 15;90(14):6489-6501
An miRNA-mediated therapy for SCA6 blocks IRES-driven translation of the CACNA1A second cistron.
Miyazaki Y, Du X, Muramatsu S, Gomez CM
Science translational medicine 2016 Jul 13;8(347):347ra94
Science translational medicine 2016 Jul 13;8(347):347ra94
A Conserved Interaction between a C-Terminal Motif in Norovirus VPg and the HEAT-1 Domain of eIF4G Is Essential for Translation Initiation.
Leen EN, Sorgeloos F, Correia S, Chaudhry Y, Cannac F, Pastore C, Xu Y, Graham SC, Matthews SJ, Goodfellow IG, Curry S
PLoS pathogens 2016 Jan;12(1):e1005379
PLoS pathogens 2016 Jan;12(1):e1005379
Mitochondrial Ribosomal Protein L12 Is Required for POLRMT Stability and Exists as Two Forms Generated by Alternative Proteolysis during Import.
Nouws J, Goswami AV, Bestwick M, McCann BJ, Surovtseva YV, Shadel GS
The Journal of biological chemistry 2016 Jan 8;291(2):989-97
The Journal of biological chemistry 2016 Jan 8;291(2):989-97
Bromodomain inhibition of the transcriptional coactivators CBP/EP300 as a therapeutic strategy to target the IRF4 network in multiple myeloma.
Conery AR, Centore RC, Neiss A, Keller PJ, Joshi S, Spillane KL, Sandy P, Hatton C, Pardo E, Zawadzke L, Bommi-Reddy A, Gascoigne KE, Bryant BM, Mertz JA, Sims RJ
eLife 2016 Jan 5;5
eLife 2016 Jan 5;5
Nuclear AURKA acquires kinase-independent transactivating function to enhance breast cancer stem cell phenotype.
Zheng F, Yue C, Li G, He B, Cheng W, Wang X, Yan M, Long Z, Qiu W, Yuan Z, Xu J, Liu B, Shi Q, Lam EW, Hung MC, Liu Q
Nature communications 2016 Jan 19;7:10180
Nature communications 2016 Jan 19;7:10180
Uncoupling of EGFR-RAS signaling and nuclear localization of YBX1 in colorectal cancer.
Roßner F, Gieseler C, Morkel M, Royer HD, Rivera M, Bläker H, Dietel M, Schäfer R, Sers C
Oncogenesis 2016 Jan 18;5(1):e187
Oncogenesis 2016 Jan 18;5(1):e187
The Neuregulin1/ErbB system is selectively regulated during peripheral nerve degeneration and regeneration.
Ronchi G, Haastert-Talini K, Fornasari BE, Perroteau I, Geuna S, Gambarotta G
The European journal of neuroscience 2016 Feb;43(3):351-64
The European journal of neuroscience 2016 Feb;43(3):351-64
Dual PI-3 kinase/mTOR inhibition impairs autophagy flux and induces cell death independent of apoptosis and necroptosis.
Button RW, Vincent JH, Strang CJ, Luo S
Oncotarget 2016 Feb 2;7(5):5157-75
Oncotarget 2016 Feb 2;7(5):5157-75
cJun N-terminal kinase (JNK) phosphorylation of serine 36 is critical for p66Shc activation.
Khalid S, Drasche A, Thurner M, Hermann M, Ashraf MI, Fresser F, Baier G, Kremser L, Lindner H, Troppmair J
Scientific reports 2016 Feb 12;6:20930
Scientific reports 2016 Feb 12;6:20930
Molecular Basis for Inhibition of the Na+/Citrate Transporter NaCT (SLC13A5) by Dicarboxylate Inhibitors.
Pajor AM, de Oliveira CA, Song K, Huard K, Shanmugasundaram V, Erion DM
Molecular pharmacology 2016 Dec;90(6):755-765
Molecular pharmacology 2016 Dec;90(6):755-765
Directed evolution using dCas9-targeted somatic hypermutation in mammalian cells.
Hess GT, Frésard L, Han K, Lee CH, Li A, Cimprich KA, Montgomery SB, Bassik MC
Nature methods 2016 Dec;13(12):1036-1042
Nature methods 2016 Dec;13(12):1036-1042
Loss of β-adrenergic-stimulated phosphorylation of CaV1.2 channels on Ser1700 leads to heart failure.
Yang L, Dai DF, Yuan C, Westenbroek RE, Yu H, West N, de la Iglesia HO, Catterall WA
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 6;113(49):E7976-E7985
Proceedings of the National Academy of Sciences of the United States of America 2016 Dec 6;113(49):E7976-E7985
Combined targeting of SET and tyrosine kinases provides an effective therapeutic approach in human T-cell acute lymphoblastic leukemia.
Richard NP, Pippa R, Cleary MM, Puri A, Tibbitts D, Mahmood S, Christensen DJ, Jeng S, McWeeney S, Look AT, Chang BH, Tyner JW, Vitek MP, Odero MD, Sears R, Agarwal A
Oncotarget 2016 Dec 20;7(51):84214-84227
Oncotarget 2016 Dec 20;7(51):84214-84227
Pattern of RECK CpG methylation as a potential marker for predicting breast cancer prognosis and drug-sensitivity.
Shi G, Yoshida Y, Yuki K, Nishimura T, Kawata Y, Kawashima M, Iwaisako K, Yoshikawa K, Kurebayashi J, Toi M, Noda M
Oncotarget 2016 Dec 13;7(50):82158-82169
Oncotarget 2016 Dec 13;7(50):82158-82169
Tbc1d1 deletion suppresses obesity in leptin-deficient mice.
Dokas J, Chadt A, Joost HG, Al-Hasani H
International journal of obesity (2005) 2016 Aug;40(8):1242-9
International journal of obesity (2005) 2016 Aug;40(8):1242-9
Lung injury-induced skeletal muscle wasting in aged mice is linked to alterations in long chain fatty acid metabolism.
Files DC, Ilaiwy A, Parry TL, Gibbs KW, Liu C, Bain JR, Delbono O, Muehlbauer MJ, Willis MS
Metabolomics : Official journal of the Metabolomic Society 2016 Aug;12(8)
Metabolomics : Official journal of the Metabolomic Society 2016 Aug;12(8)
The Deubiquitinase OTULIN Is an Essential Negative Regulator of Inflammation and Autoimmunity.
Damgaard RB, Walker JA, Marco-Casanova P, Morgan NV, Titheradge HL, Elliott PR, McHale D, Maher ER, McKenzie ANJ, Komander D
Cell 2016 Aug 25;166(5):1215-1230.e20
Cell 2016 Aug 25;166(5):1215-1230.e20
Connexin43 recruits PTEN and Csk to inhibit c-Src activity in glioma cells and astrocytes.
González-Sánchez A, Jaraíz-Rodríguez M, Domínguez-Prieto M, Herrero-González S, Medina JM, Tabernero A
Oncotarget 2016 Aug 2;7(31):49819-49833
Oncotarget 2016 Aug 2;7(31):49819-49833
PtdIns(3,4,5)P3-dependent Rac Exchanger 1 (PREX1) Rac-Guanine Nucleotide Exchange Factor (GEF) Activity Promotes Breast Cancer Cell Proliferation and Tumor Growth via Activation of Extracellular Signal-regulated Kinase 1/2 (ERK1/2) Signaling.
Liu HJ, Ooms LM, Srijakotre N, Man J, Vieusseux J, Waters JE, Feng Y, Bailey CG, Rasko JE, Price JT, Mitchell CA
The Journal of biological chemistry 2016 Aug 12;291(33):17258-70
The Journal of biological chemistry 2016 Aug 12;291(33):17258-70
The caffeine-binding adenosine A2A receptor induces age-like HPA-axis dysfunction by targeting glucocorticoid receptor function.
Batalha VL, Ferreira DG, Coelho JE, Valadas JS, Gomes R, Temido-Ferreira M, Shmidt T, Baqi Y, Buée L, Müller CE, Hamdane M, Outeiro TF, Bader M, Meijsing SH, Sadri-Vakili G, Blum D, Lopes LV
Scientific reports 2016 Aug 11;6:31493
Scientific reports 2016 Aug 11;6:31493
Diacylglycerol pyrophosphate binds and inhibits the glyceraldehyde-3-phosphate dehydrogenase in barley aleurone.
Astorquiza PL, Usorach J, Racagni G, Villasuso AL
Plant physiology and biochemistry : PPB 2016 Apr;101:88-95
Plant physiology and biochemistry : PPB 2016 Apr;101:88-95
Selective inhibition of the kinase DYRK1A by targeting its folding process.
Kii I, Sumida Y, Goto T, Sonamoto R, Okuno Y, Yoshida S, Kato-Sumida T, Koike Y, Abe M, Nonaka Y, Ikura T, Ito N, Shibuya H, Hosoya T, Hagiwara M
Nature communications 2016 Apr 22;7:11391
Nature communications 2016 Apr 22;7:11391
Filamin B Enhances the Invasiveness of Cancer Cells into 3D Collagen Matrices.
Iguchi Y, Ishihara S, Uchida Y, Tajima K, Mizutani T, Kawabata K, Haga H
Cell structure and function 2015;40(2):61-7
Cell structure and function 2015;40(2):61-7
Reduced keratin expression in colorectal neoplasia and associated fields is reversible by diet and resection.
Evans CA, Rosser R, Waby JS, Noirel J, Lai D, Wright PC, Williams EA, Riley SA, Bury JP, Corfe BM
BMJ open gastroenterology 2015;2(1):e000022
BMJ open gastroenterology 2015;2(1):e000022
RIPK1 regulates survival of human melanoma cells upon endoplasmic reticulum stress through autophagy.
Luan Q, Jin L, Jiang CC, Tay KH, Lai F, Liu XY, Liu YL, Guo ST, Li CY, Yan XG, Tseng HY, Zhang XD
Autophagy 2015;11(7):975-94
Autophagy 2015;11(7):975-94
Integrity of the Pericentriolar Material Is Essential for Maintaining Centriole Association during M Phase.
Seo MY, Jang W, Rhee K
PloS one 2015;10(9):e0138905
PloS one 2015;10(9):e0138905
Shigella infection interferes with SUMOylation and increases PML-NB number.
Sidik SM, Salsman J, Dellaire G, Rohde JR
PloS one 2015;10(4):e0122585
PloS one 2015;10(4):e0122585
Compressive stress induces dephosphorylation of the myosin regulatory light chain via RhoA phosphorylation by the adenylyl cyclase/protein kinase A signaling pathway.
Takemoto K, Ishihara S, Mizutani T, Kawabata K, Haga H
PloS one 2015;10(3):e0117937
PloS one 2015;10(3):e0117937
Losartan Treatment Protects Retinal Ganglion Cells and Alters Scleral Remodeling in Experimental Glaucoma.
Quigley HA, Pitha IF, Welsbie DS, Nguyen C, Steinhart MR, Nguyen TD, Pease ME, Oglesby EN, Berlinicke CA, Mitchell KL, Kim J, Jefferys JJ, Kimball EC
PloS one 2015;10(10):e0141137
PloS one 2015;10(10):e0141137
Structural insight into selectivity and resistance profiles of ROS1 tyrosine kinase inhibitors.
Davare MA, Vellore NA, Wagner JP, Eide CA, Goodman JR, Drilon A, Deininger MW, O'Hare T, Druker BJ
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 29;112(39):E5381-90
Proceedings of the National Academy of Sciences of the United States of America 2015 Sep 29;112(39):E5381-90
High-efficiency reprogramming of fibroblasts into cardiomyocytes requires suppression of pro-fibrotic signalling.
Zhao Y, Londono P, Cao Y, Sharpe EJ, Proenza C, O'Rourke R, Jones KL, Jeong MY, Walker LA, Buttrick PM, McKinsey TA, Song K
Nature communications 2015 Sep 10;6:8243
Nature communications 2015 Sep 10;6:8243
Nitric Oxide-cGMP-PKG Pathway Acts on Orai1 to Inhibit the Hypertrophy of Human Embryonic Stem Cell-Derived Cardiomyocytes.
Wang Y, Li ZC, Zhang P, Poon E, Kong CW, Boheler KR, Huang Y, Li RA, Yao X
Stem cells (Dayton, Ohio) 2015 Oct;33(10):2973-84
Stem cells (Dayton, Ohio) 2015 Oct;33(10):2973-84
TRIM29 regulates the p63-mediated pathway in cervical cancer cells.
Masuda Y, Takahashi H, Hatakeyama S
Biochimica et biophysica acta 2015 Oct;1853(10 Pt A):2296-305
Biochimica et biophysica acta 2015 Oct;1853(10 Pt A):2296-305
A phosphoinositide-binding cluster in cavin1 acts as a molecular sensor for cavin1 degradation.
Tillu VA, Kovtun O, McMahon KA, Collins BM, Parton RG
Molecular biology of the cell 2015 Oct 15;26(20):3561-9
Molecular biology of the cell 2015 Oct 15;26(20):3561-9
Astrocyte NMDA receptors' activity sustains neuronal survival through a Cdk5-Nrf2 pathway.
Jimenez-Blasco D, Santofimia-Castaño P, Gonzalez A, Almeida A, Bolaños JP
Cell death and differentiation 2015 Nov;22(11):1877-89
Cell death and differentiation 2015 Nov;22(11):1877-89
Antigen-B Cell Receptor Complexes Associate with Intracellular major histocompatibility complex (MHC) Class II Molecules.
Barroso M, Tucker H, Drake L, Nichol K, Drake JR
The Journal of biological chemistry 2015 Nov 6;290(45):27101-27112
The Journal of biological chemistry 2015 Nov 6;290(45):27101-27112
Dysregulated miRNA biogenesis downstream of cellular stress and ALS-causing mutations: a new mechanism for ALS.
Emde A, Eitan C, Liou LL, Libby RT, Rivkin N, Magen I, Reichenstein I, Oppenheim H, Eilam R, Silvestroni A, Alajajian B, Ben-Dov IZ, Aebischer J, Savidor A, Levin Y, Sons R, Hammond SM, Ravits JM, Möller T, Hornstein E
The EMBO journal 2015 Nov 3;34(21):2633-51
The EMBO journal 2015 Nov 3;34(21):2633-51
Syk Is Recruited to Stress Granules and Promotes Their Clearance through Autophagy.
Krisenko MO, Higgins RL, Ghosh S, Zhou Q, Trybula JS, Wang WH, Geahlen RL
The Journal of biological chemistry 2015 Nov 13;290(46):27803-15
The Journal of biological chemistry 2015 Nov 13;290(46):27803-15
Identification of intellectual disability genes showing circadian clock-dependent expression in the mouse hippocampus.
Renaud J, Dumont F, Khelfaoui M, Foisset SR, Letourneur F, Bienvenu T, Khwaja O, Dorseuil O, Billuart P
Neuroscience 2015 Nov 12;308:11-50
Neuroscience 2015 Nov 12;308:11-50
MiR-497∼195 cluster microRNAs regulate osteoblast differentiation by targeting BMP signaling.
Grünhagen J, Bhushan R, Degenkolbe E, Jäger M, Knaus P, Mundlos S, Robinson PN, Ott CE
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 May;30(5):796-808
Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research 2015 May;30(5):796-808
Mitogen-Activated Protein Kinase 8 (MAP3K8) Mediates the Signaling Pathway of Estradiol Stimulating Progesterone Production Through G Protein-Coupled Receptor 30 (GPR30) in Mouse Corpus Luteum.
Liu Y, Li Y, Zhang D, Liu J, Gou K, Cui S
Molecular endocrinology (Baltimore, Md.) 2015 May;29(5):703-15
Molecular endocrinology (Baltimore, Md.) 2015 May;29(5):703-15
Missense variant in CCDC22 causes X-linked recessive intellectual disability with features of Ritscher-Schinzel/3C syndrome.
Kolanczyk M, Krawitz P, Hecht J, Hupalowska A, Miaczynska M, Marschner K, Schlack C, Emmerich D, Kobus K, Kornak U, Robinson PN, Plecko B, Grangl G, Uhrig S, Mundlos S, Horn D
European journal of human genetics : EJHG 2015 May;23(5):633-8
European journal of human genetics : EJHG 2015 May;23(5):633-8
Increased CCN2, substance P and tissue fibrosis are associated with sensorimotor declines in a rat model of repetitive overuse injury.
Fisher PW, Zhao Y, Rico MC, Massicotte VS, Wade CK, Litvin J, Bove GM, Popoff SN, Barbe MF
Journal of cell communication and signaling 2015 Mar;9(1):37-54
Journal of cell communication and signaling 2015 Mar;9(1):37-54
CD200: association with cancer stem cell features and response to chemoradiation in head and neck squamous cell carcinoma.
Jung YS, Vermeer PD, Vermeer DW, Lee SJ, Goh AR, Ahn HJ, Lee JH
Head & neck 2015 Mar;37(3):327-35
Head & neck 2015 Mar;37(3):327-35
The ribosome biogenesis factor Nol11 is required for optimal rDNA transcription and craniofacial development in Xenopus.
Griffin JN, Sondalle SB, Del Viso F, Baserga SJ, Khokha MK
PLoS genetics 2015 Mar;11(3):e1005018
PLoS genetics 2015 Mar;11(3):e1005018
Genomic analysis of LPS-stimulated myeloid cells identifies a common pro-inflammatory response but divergent IL-10 anti-inflammatory responses.
Hutchins AP, Takahashi Y, Miranda-Saavedra D
Scientific reports 2015 Mar 13;5:9100
Scientific reports 2015 Mar 13;5:9100
Therapeutic exercise attenuates neutrophilic lung injury and skeletal muscle wasting.
Files DC, Liu C, Pereyra A, Wang ZM, Aggarwal NR, D'Alessio FR, Garibaldi BT, Mock JR, Singer BD, Feng X, Yammani RR, Zhang T, Lee AL, Philpott S, Lussier S, Purcell L, Chou J, Seeds M, King LS, Morris PE, Delbono O
Science translational medicine 2015 Mar 11;7(278):278ra32
Science translational medicine 2015 Mar 11;7(278):278ra32
Resveratrol attenuates microvascular inflammation in sepsis via SIRT-1-Induced modulation of adhesion molecules in ob/ob mice.
Wang X, Buechler NL, Yoza BK, McCall CE, Vachharajani VT
Obesity (Silver Spring, Md.) 2015 Jun;23(6):1209-17
Obesity (Silver Spring, Md.) 2015 Jun;23(6):1209-17
A mouse model suggests two mechanisms for thyroid alterations in infantile cystinosis: decreased thyroglobulin synthesis due to endoplasmic reticulum stress/unfolded protein response and impaired lysosomal processing.
Gaide Chevronnay HP, Janssens V, Van Der Smissen P, Liao XH, Abid Y, Nevo N, Antignac C, Refetoff S, Cherqui S, Pierreux CE, Courtoy PJ
Endocrinology 2015 Jun;156(6):2349-64
Endocrinology 2015 Jun;156(6):2349-64
Parathyroid Hormone-Related Protein, Human Adipose-Derived Stem Cells Adipogenic Capacity and Healthy Obesity.
Roca-Rodríguez MM, El Bekay R, Garrido-Sanchez L, Gómez-Serrano M, Coin-Aragüez L, Oliva-Olivera W, Lhamyani S, Clemente-Postigo M, García-Santos E, de Luna Diaz R, Yubero-Serrano EM, Fernández Real JM, Peral B, Tinahones FJ
The Journal of clinical endocrinology and metabolism 2015 Jun;100(6):E826-35
The Journal of clinical endocrinology and metabolism 2015 Jun;100(6):E826-35
TRIM29 regulates the assembly of DNA repair proteins into damaged chromatin.
Masuda Y, Takahashi H, Sato S, Tomomori-Sato C, Saraf A, Washburn MP, Florens L, Conaway RC, Conaway JW, Hatakeyama S
Nature communications 2015 Jun 22;6:7299
Nature communications 2015 Jun 22;6:7299
Aurora Kinase B Regulates Telomerase Activity via a Centromeric RNA in Stem Cells.
Mallm JP, Rippe K
Cell reports 2015 Jun 16;11(10):1667-78
Cell reports 2015 Jun 16;11(10):1667-78
The MAL protein is crucial for proper membrane condensation at the ciliary base, which is required for primary cilium elongation.
Reales E, Bernabé-Rubio M, Casares-Arias J, Rentero C, Fernández-Barrera J, Rangel L, Correas I, Enrich C, Andrés G, Alonso MA
Journal of cell science 2015 Jun 15;128(12):2261-70
Journal of cell science 2015 Jun 15;128(12):2261-70
Transgenic expression of oncogenic BRAF induces loss of stem cells in the mouse intestine, which is antagonized by β-catenin activity.
Riemer P, Sreekumar A, Reinke S, Rad R, Schäfer R, Sers C, Bläker H, Herrmann BG, Morkel M
Oncogene 2015 Jun 11;34(24):3164-75
Oncogene 2015 Jun 11;34(24):3164-75
Molecular Role of RNF43 in Canonical and Noncanonical Wnt Signaling.
Tsukiyama T, Fukui A, Terai S, Fujioka Y, Shinada K, Takahashi H, Yamaguchi TP, Ohba Y, Hatakeyama S
Molecular and cellular biology 2015 Jun 1;35(11):2007-23
Molecular and cellular biology 2015 Jun 1;35(11):2007-23
Determinant role for the gep oncogenes, Gα12/13, in ovarian cancer cell proliferation and xenograft tumor growth.
Ha JH, Gomathinayagam R, Yan M, Jayaraman M, Ramesh R, Dhanasekaran DN
Genes & cancer 2015 Jul;6(7-8):356-364
Genes & cancer 2015 Jul;6(7-8):356-364
Metformin increases peroxisome proliferator-activated receptor γ Co-activator-1α and utrophin a expression in dystrophic skeletal muscle.
Ljubicic V, Jasmin BJ
Muscle & nerve 2015 Jul;52(1):139-42
Muscle & nerve 2015 Jul;52(1):139-42
Calcitriol ameliorates renal damage in a pre-established proteinuria model.
Maquigussa E, Arnoni CP, Pereira LG, Boim MA
Molecular medicine reports 2015 Jul;12(1):1009-15
Molecular medicine reports 2015 Jul;12(1):1009-15
Identification of residues in the human respiratory syncytial virus fusion protein that modulate fusion activity and pathogenesis.
Hotard AL, Lee S, Currier MG, Crowe JE Jr, Sakamoto K, Newcomb DC, Peebles RS Jr, Plemper RK, Moore ML
Journal of virology 2015 Jan;89(1):512-22
Journal of virology 2015 Jan;89(1):512-22
Transcription factor Mohawk controls tenogenic differentiation of bone marrow mesenchymal stem cells in vitro and in vivo.
Otabe K, Nakahara H, Hasegawa A, Matsukawa T, Ayabe F, Onizuka N, Inui M, Takada S, Ito Y, Sekiya I, Muneta T, Lotz M, Asahara H
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Jan;33(1):1-8
Journal of orthopaedic research : official publication of the Orthopaedic Research Society 2015 Jan;33(1):1-8
Schizophrenia-like phenotype of polysialyltransferase ST8SIA2-deficient mice.
Kröcher T, Malinovskaja K, Jürgenson M, Aonurm-Helm A, Zharkovskaya T, Kalda A, Röckle I, Schiff M, Weinhold B, Gerardy-Schahn R, Hildebrandt H, Zharkovsky A
Brain structure & function 2015 Jan;220(1):71-83
Brain structure & function 2015 Jan;220(1):71-83
Analysis of human papillomavirus E7 protein status in C-33A cervical cancer cells.
Kaiser A, Jenewein B, Pircher H, Rostek U, Jansen-Dürr P, Zwerschke W
Virus genes 2015 Feb;50(1):12-21
Virus genes 2015 Feb;50(1):12-21
GAPDH and β-actin protein decreases with aging, making Stain-Free technology a superior loading control in Western blotting of human skeletal muscle.
Vigelsø A, Dybboe R, Hansen CN, Dela F, Helge JW, Guadalupe Grau A
Journal of applied physiology (Bethesda, Md. : 1985) 2015 Feb 1;118(3):386-94
Journal of applied physiology (Bethesda, Md. : 1985) 2015 Feb 1;118(3):386-94
FOXG1 expression shows correlation with neuronal differentiation in cerebellar development, aggressive phenotype in medulloblastomas, and survival in a xenograft model of medulloblastoma.
Adesina AM, Veo BL, Courteau G, Mehta V, Wu X, Pang K, Liu Z, Li XN, Peters L
Human pathology 2015 Dec;46(12):1859-71
Human pathology 2015 Dec;46(12):1859-71
Tamoxifen Inhibits TGF-β-Mediated Activation of Myofibroblasts by Blocking Non-Smad Signaling Through ERK1/2.
Carthy JM, Sundqvist A, Heldin A, van Dam H, Kletsas D, Heldin CH, Moustakas A
Journal of cellular physiology 2015 Dec;230(12):3084-92
Journal of cellular physiology 2015 Dec;230(12):3084-92
S100A8, An Oocyte-Specific Chemokine, Directs the Migration of Ovarian Somatic Cells During Mouse Primordial Follicle Assembly.
Teng Z, Wang C, Wang Y, Huang K, Xiang X, Niu W, Feng L, Zhao L, Yan H, Zhang H, Xia G
Journal of cellular physiology 2015 Dec;230(12):2998-3008
Journal of cellular physiology 2015 Dec;230(12):2998-3008
PLK1 regulation of PCNT cleavage ensures fidelity of centriole separation during mitotic exit.
Kim J, Lee K, Rhee K
Nature communications 2015 Dec 9;6:10076
Nature communications 2015 Dec 9;6:10076
Transforming Growth Factor-β1 Induced Epithelial Mesenchymal Transition is blocked by a chemical antagonist of translation factor eIF4E.
Smith KA, Zhou B, Avdulov S, Benyumov A, Peterson M, Liu Y, Okon A, Hergert P, Braziunas J, Wagner CR, Borok Z, Bitterman PB
Scientific reports 2015 Dec 18;5:18233
Scientific reports 2015 Dec 18;5:18233
Inflammatory but not apoptotic death of granulocytes citrullinates fibrinogen.
Blachère NE, Parveen S, Fak J, Frank MO, Orange DE
Arthritis research & therapy 2015 Dec 17;17:369
Arthritis research & therapy 2015 Dec 17;17:369
CRISPR/Cas9: An inexpensive, efficient loss of function tool to screen human disease genes in Xenopus.
Bhattacharya D, Marfo CA, Li D, Lane M, Khokha MK
Developmental biology 2015 Dec 15;408(2):196-204
Developmental biology 2015 Dec 15;408(2):196-204
MytiLec, a Mussel R-Type Lectin, Interacts with Surface Glycan Gb3 on Burkitt's Lymphoma Cells to Trigger Apoptosis through Multiple Pathways.
Hasan I, Sugawara S, Fujii Y, Koide Y, Terada D, Iimura N, Fujiwara T, Takahashi KG, Kojima N, Rajia S, Kawsar SM, Kanaly RA, Uchiyama H, Hosono M, Ogawa Y, Fujita H, Hamako J, Matsui T, Ozeki Y
Marine drugs 2015 Dec 14;13(12):7377-89
Marine drugs 2015 Dec 14;13(12):7377-89
Functional Analysis of the 60-Nucleotide Duplication in the Respiratory Syncytial Virus Buenos Aires Strain Attachment Glycoprotein.
Hotard AL, Laikhter E, Brooks K, Hartert TV, Moore ML
Journal of virology 2015 Aug;89(16):8258-66
Journal of virology 2015 Aug;89(16):8258-66
Hepatocyte Nicotinamide Adenine Dinucleotide Phosphate Reduced Oxidase 4 Regulates Stress Signaling, Fibrosis, and Insulin Sensitivity During Development of Steatohepatitis in Mice.
Bettaieb A, Jiang JX, Sasaki Y, Chao TI, Kiss Z, Chen X, Tian J, Katsuyama M, Yabe-Nishimura C, Xi Y, Szyndralewiez C, Schröder K, Shah A, Brandes RP, Haj FG, Török NJ
Gastroenterology 2015 Aug;149(2):468-80.e10
Gastroenterology 2015 Aug;149(2):468-80.e10
An siRNA Screen Identifies the U2 snRNP Spliceosome as a Host Restriction Factor for Recombinant Adeno-associated Viruses.
Schreiber CA, Sakuma T, Izumiya Y, Holditch SJ, Hickey RD, Bressin RK, Basu U, Koide K, Asokan A, Ikeda Y
PLoS pathogens 2015 Aug;11(8):e1005082
PLoS pathogens 2015 Aug;11(8):e1005082
Molecular Determinants for the Inactivation of the Retinoblastoma Tumor Suppressor by the Viral Cyclin-dependent Kinase UL97.
Iwahori S, Hakki M, Chou S, Kalejta RF
The Journal of biological chemistry 2015 Aug 7;290(32):19666-80
The Journal of biological chemistry 2015 Aug 7;290(32):19666-80
A Dual SILAC Proteomic Labeling Strategy for Quantifying Constitutive and Cell-Cell Induced Protein Secretion.
Stiess M, Wegehingel S, Nguyen C, Nickel W, Bradke F, Cambridge SB
Journal of proteome research 2015 Aug 7;14(8):3229-38
Journal of proteome research 2015 Aug 7;14(8):3229-38
Loss of giant obscurins from breast epithelium promotes epithelial-to-mesenchymal transition, tumorigenicity and metastasis.
Shriver M, Stroka KM, Vitolo MI, Martin S, Huso DL, Konstantopoulos K, Kontrogianni-Konstantopoulos A
Oncogene 2015 Aug 6;34(32):4248-59
Oncogene 2015 Aug 6;34(32):4248-59
Turning terminally differentiated skeletal muscle cells into regenerative progenitors.
Wang H, Lööf S, Borg P, Nader GA, Blau HM, Simon A
Nature communications 2015 Aug 5;6:7916
Nature communications 2015 Aug 5;6:7916
Loss of auditory activity modifies the location of potassium channel KCNQ5 in auditory brainstem neurons.
Caminos E, Garcia-Pino E, Juiz JM
Journal of neuroscience research 2015 Apr;93(4):604-14
Journal of neuroscience research 2015 Apr;93(4):604-14
Rapamycin-mediated mTORC2 inhibition is determined by the relative expression of FK506-binding proteins.
Schreiber KH, Ortiz D, Academia EC, Anies AC, Liao CY, Kennedy BK
Aging cell 2015 Apr;14(2):265-73
Aging cell 2015 Apr;14(2):265-73
An analysis of critical factors for quantitative immunoblotting.
Janes KA
Science signaling 2015 Apr 7;8(371):rs2
Science signaling 2015 Apr 7;8(371):rs2
Mitochondrial DNA stress primes the antiviral innate immune response.
West AP, Khoury-Hanold W, Staron M, Tal MC, Pineda CM, Lang SM, Bestwick M, Duguay BA, Raimundo N, MacDuff DA, Kaech SM, Smiley JR, Means RE, Iwasaki A, Shadel GS
Nature 2015 Apr 23;520(7548):553-7
Nature 2015 Apr 23;520(7548):553-7
Native elongating transcript sequencing reveals human transcriptional activity at nucleotide resolution.
Mayer A, di Iulio J, Maleri S, Eser U, Vierstra J, Reynolds A, Sandstrom R, Stamatoyannopoulos JA, Churchman LS
Cell 2015 Apr 23;161(3):541-554
Cell 2015 Apr 23;161(3):541-554
Transcriptional activity of the islet β cell factor Pdx1 is augmented by lysine methylation catalyzed by the methyltransferase Set7/9.
Maganti AV, Maier B, Tersey SA, Sampley ML, Mosley AL, Özcan S, Pachaiyappan B, Woster PM, Hunter CS, Stein R, Mirmira RG
The Journal of biological chemistry 2015 Apr 10;290(15):9812-22
The Journal of biological chemistry 2015 Apr 10;290(15):9812-22
Parkinson disease mutant E46K enhances α-synuclein phosphorylation in mammalian cell lines, in yeast, and in vivo.
Mbefo MK, Fares MB, Paleologou K, Oueslati A, Yin G, Tenreiro S, Pinto M, Outeiro T, Zweckstetter M, Masliah E, Lashuel HA
The Journal of biological chemistry 2015 Apr 10;290(15):9412-27
The Journal of biological chemistry 2015 Apr 10;290(15):9412-27
CX3CL1 (fractalkine) protein expression in normal and degenerating mouse retina: in vivo studies.
Zieger M, Ahnelt PK, Uhrin P
PloS one 2014;9(9):e106562
PloS one 2014;9(9):e106562
PiZ mouse liver accumulates polyubiquitin conjugates that associate with catalytically active 26S proteasomes.
Haddock CJ, Blomenkamp K, Gautam M, James J, Mielcarska J, Gogol E, Teckman J, Skowyra D
PloS one 2014;9(9):e106371
PloS one 2014;9(9):e106371
Uridine 5'-triphosphate promotes in vitro Schwannoma cell migration through matrix metalloproteinase-2 activation.
Lamarca A, Gella A, Martiañez T, Segura M, Figueiro-Silva J, Grijota-Martinez C, Trullas R, Casals N
PloS one 2014;9(6):e98998
PloS one 2014;9(6):e98998
Serum stability and physicochemical characterization of a novel amphipathic peptide C6M1 for siRNA delivery.
Jafari M, Xu W, Pan R, Sweeting CM, Karunaratne DN, Chen P
PloS one 2014;9(5):e97797
PloS one 2014;9(5):e97797
Zscan4 is regulated by PI3-kinase and DNA-damaging agents and directly interacts with the transcriptional repressors LSD1 and CtBP2 in mouse embryonic stem cells.
Storm MP, Kumpfmueller B, Bone HK, Buchholz M, Sanchez Ripoll Y, Chaudhuri JB, Niwa H, Tosh D, Welham MJ
PloS one 2014;9(3):e89821
PloS one 2014;9(3):e89821
Casein kinase II inhibitor enhances production of infectious genotype 1a hepatitis C virus (H77S).
Kim S, Jin B, Choi SH, Han KH, Ahn SH
PloS one 2014;9(12):e113938
PloS one 2014;9(12):e113938
Role of D-Limonene in autophagy induced by bergamot essential oil in SH-SY5Y neuroblastoma cells.
Russo R, Cassiano MG, Ciociaro A, Adornetto A, Varano GP, Chiappini C, Berliocchi L, Tassorelli C, Bagetta G, Corasaniti MT
PloS one 2014;9(11):e113682
PloS one 2014;9(11):e113682
L-Endoglin overexpression increases renal fibrosis after unilateral ureteral obstruction.
Oujo B, Muñoz-Félix JM, Arévalo M, Núñez-Gómez E, Pérez-Roque L, Pericacho M, González-Núñez M, Langa C, Martínez-Salgado C, Perez-Barriocanal F, Bernabeu C, Lopez-Novoa JM
PloS one 2014;9(10):e110365
PloS one 2014;9(10):e110365
Release of tensile strain on engineered human tendon tissue disturbs cell adhesions, changes matrix architecture, and induces an inflammatory phenotype.
Bayer ML, Schjerling P, Herchenhan A, Zeltz C, Heinemeier KM, Christensen L, Krogsgaard M, Gullberg D, Kjaer M
PloS one 2014;9(1):e86078
PloS one 2014;9(1):e86078
Atoxic derivative of botulinum neurotoxin A as a prototype molecular vehicle for targeted delivery to the neuronal cytoplasm.
Vazquez-Cintron EJ, Vakulenko M, Band PA, Stanker LH, Johnson EA, Ichtchenko K
PloS one 2014;9(1):e85517
PloS one 2014;9(1):e85517
Overexpression of aquaporin 1 in the tunica vaginalis may contribute to adult-onset primary hydrocele testis.
Hattori M, Tonooka A, Zaitsu M, Mikami K, Suzue-Yanagisawa A, Uekusa T, Takeuchi T
Advances in urology 2014;2014:202434
Advances in urology 2014;2014:202434
CD137 enhancement of HPV positive head and neck squamous cell carcinoma tumor clearance.
Lucido CT, Vermeer PD, Wieking BG, Vermeer DW, Lee JH
Vaccines 2014;2(4):841-53
Vaccines 2014;2(4):841-53
Ras-mediated deregulation of the circadian clock in cancer.
Relógio A, Thomas P, Medina-Pérez P, Reischl S, Bervoets S, Gloc E, Riemer P, Mang-Fatehi S, Maier B, Schäfer R, Leser U, Herzel H, Kramer A, Sers C
PLoS genetics 2014;10(5):e1004338
PLoS genetics 2014;10(5):e1004338
IFNG-mediated immune responses enhance autophagy against Mycobacterium tuberculosis antigens in patients with active tuberculosis.
Rovetta AI, Peña D, Hernández Del Pino RE, Recalde GM, Pellegrini J, Bigi F, Musella RM, Palmero DJ, Gutierrez M, Colombo MI, García VE
Autophagy 2014;10(12):2109-21
Autophagy 2014;10(12):2109-21
Protein arginine methyltransferase 6 enhances ligand-dependent and -independent activity of estrogen receptor α via distinct mechanisms.
Sun Y, Chung HH, Woo AR, Lin VC
Biochimica et biophysica acta 2014 Sep;1843(9):2067-78
Biochimica et biophysica acta 2014 Sep;1843(9):2067-78
A human monoclonal antibody targeting the stem cell factor receptor (c-Kit) blocks tumor cell signaling and inhibits tumor growth.
Lebron MB, Brennan L, Damoci CB, Prewett MC, O'Mahony M, Duignan IJ, Credille KM, DeLigio JT, Starodubtseva M, Amatulli M, Zhang Y, Schwartz KD, Burtrum D, Balderes P, Persaud K, Surguladze D, Loizos N, Paz K, Kotanides H
Cancer biology & therapy 2014 Sep;15(9):1208-18
Cancer biology & therapy 2014 Sep;15(9):1208-18
Lack of effect of a P2Y6 receptor antagonist on neuropathic pain behavior in mice.
Syhr KM, Kallenborn-Gerhardt W, Lu R, Olbrich K, Schmitz K, Männich J, Ferreiros-Bouzas N, Geisslinger G, Niederberger E, Schmidtko A
Pharmacology, biochemistry, and behavior 2014 Sep;124:389-95
Pharmacology, biochemistry, and behavior 2014 Sep;124:389-95
Osteopontin is an important mediator of alcoholic liver disease via hepatic stellate cell activation.
Seth D, Duly A, Kuo PC, McCaughan GW, Haber PS
World journal of gastroenterology 2014 Sep 28;20(36):13088-104
World journal of gastroenterology 2014 Sep 28;20(36):13088-104
Discoidin domain receptor 2 germline gene deletion leads to altered heart structure and function in the mouse.
Cowling RT, Yeo SJ, Kim IJ, Park JI, Gu Y, Dalton ND, Peterson KL, Greenberg BH
American journal of physiology. Heart and circulatory physiology 2014 Sep 1;307(5):H773-81
American journal of physiology. Heart and circulatory physiology 2014 Sep 1;307(5):H773-81
Human placental transcriptome shows sexually dimorphic gene expression and responsiveness to maternal dietary n-3 long-chain polyunsaturated fatty acid intervention during pregnancy.
Sedlmeier EM, Brunner S, Much D, Pagel P, Ulbrich SE, Meyer HH, Amann-Gassner U, Hauner H, Bader BL
BMC genomics 2014 Oct 27;15(1):941
BMC genomics 2014 Oct 27;15(1):941
SIRT1 inhibition during the hypoinflammatory phenotype of sepsis enhances immunity and improves outcome.
Vachharajani VT, Liu T, Brown CM, Wang X, Buechler NL, Wells JD, Yoza BK, McCall CE
Journal of leukocyte biology 2014 Nov;96(5):785-96
Journal of leukocyte biology 2014 Nov;96(5):785-96
Soluble-E-cadherin activates HER and IAP family members in HER2+ and TNBC human breast cancers.
Brouxhon SM, Kyrkanides S, Teng X, O'Banion MK, Clarke R, Byers S, Ma L
Molecular carcinogenesis 2014 Nov;53(11):893-906
Molecular carcinogenesis 2014 Nov;53(11):893-906
Regulation of ceramide synthase 6 in a spontaneous experimental autoimmune encephalomyelitis model is sex dependent.
Eberle M, Ebel P, Wegner MS, Männich J, Tafferner N, Ferreiros N, Birod K, Schreiber Y, Krishnamoorthy G, Willecke K, Geisslinger G, Grösch S, Schiffmann S
Biochemical pharmacology 2014 Nov 15;92(2):326-35
Biochemical pharmacology 2014 Nov 15;92(2):326-35
Cisplatin plus sodium arsenite and hyperthermia induces pseudo-G1 associated apoptotic cell death in ovarian cancer cells.
Muenyi CS, Trivedi AP, Helm CW, States JC
Toxicological sciences : an official journal of the Society of Toxicology 2014 May;139(1):74-82
Toxicological sciences : an official journal of the Society of Toxicology 2014 May;139(1):74-82
Depletion of lamina-associated polypeptide 1 from cardiomyocytes causes cardiac dysfunction in mice.
Shin JY, Le Dour C, Sera F, Iwata S, Homma S, Joseph LC, Morrow JP, Dauer WT, Worman HJ
Nucleus (Austin, Tex.) 2014 May-Jun;5(3):260-459
Nucleus (Austin, Tex.) 2014 May-Jun;5(3):260-459
Cdk5-dependent Mst3 phosphorylation and activity regulate neuronal migration through RhoA inhibition.
Tang J, Ip JP, Ye T, Ng YP, Yung WH, Wu Z, Fang W, Fu AK, Ip NY
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 28;34(22):7425-36
The Journal of neuroscience : the official journal of the Society for Neuroscience 2014 May 28;34(22):7425-36
miR-142 orchestrates a network of actin cytoskeleton regulators during megakaryopoiesis.
Chapnik E, Rivkin N, Mildner A, Beck G, Pasvolsky R, Metzl-Raz E, Birger Y, Amir G, Tirosh I, Porat Z, Israel LL, Lellouche E, Michaeli S, Lellouche JP, Izraeli S, Jung S, Hornstein E
eLife 2014 May 23;3:e01964
eLife 2014 May 23;3:e01964
Detection of WIPI1 mRNA as an indicator of autophagosome formation.
Tsuyuki S, Takabayashi M, Kawazu M, Kudo K, Watanabe A, Nagata Y, Kusama Y, Yoshida K
Autophagy 2014 Mar;10(3):497-513
Autophagy 2014 Mar;10(3):497-513
LIM homeodomain transcription factor Isl1 directs normal pyloric development by targeting Gata3.
Li Y, Pan J, Wei C, Chen J, Liu Y, Liu J, Zhang X, Evans SM, Cui Y, Cui S
BMC biology 2014 Mar 27;12:25
BMC biology 2014 Mar 27;12:25
Cyclin-dependent kinase 9 inhibition protects cartilage from the catabolic effects of proinflammatory cytokines.
Yik JH, Hu Z, Kumari R, Christiansen BA, Haudenschild DR
Arthritis & rheumatology (Hoboken, N.J.) 2014 Jun;66(6):1537-46
Arthritis & rheumatology (Hoboken, N.J.) 2014 Jun;66(6):1537-46
Coordinate phosphorylation of multiple residues on single AKT1 and AKT2 molecules.
Guo H, Gao M, Lu Y, Liang J, Lorenzi PL, Bai S, Hawke DH, Li J, Dogruluk T, Scott KL, Jonasch E, Mills GB, Ding Z
Oncogene 2014 Jun 26;33(26):3463-72
Oncogene 2014 Jun 26;33(26):3463-72
The metabolite α-ketoglutarate extends lifespan by inhibiting ATP synthase and TOR.
Chin RM, Fu X, Pai MY, Vergnes L, Hwang H, Deng G, Diep S, Lomenick B, Meli VS, Monsalve GC, Hu E, Whelan SA, Wang JX, Jung G, Solis GM, Fazlollahi F, Kaweeteerawat C, Quach A, Nili M, Krall AS, Godwin HA, Chang HR, Faull KF, Guo F, Jiang M, Trauger SA, Saghatelian A, Braas D, Christofk HR, Clarke CF, Teitell MA, Petrascheck M, Reue K, Jung ME, Frand AR, Huang J
Nature 2014 Jun 19;510(7505):397-401
Nature 2014 Jun 19;510(7505):397-401
Prevention of intestinal obstruction reveals progressive neurodegeneration in mutant TDP-43 (A315T) mice.
Herdewyn S, Cirillo C, Van Den Bosch L, Robberecht W, Vanden Berghe P, Van Damme P
Molecular neurodegeneration 2014 Jun 17;9:24
Molecular neurodegeneration 2014 Jun 17;9:24
Genetic and pharmacological strategies to refunctionalize the von Hippel Lindau R167Q mutant protein.
Ding Z, German P, Bai S, Reddy AS, Liu XD, Sun M, Zhou L, Chen X, Zhao X, Wu C, Zhang S, Mills GB, Jonasch E
Cancer research 2014 Jun 1;74(11):3127-36
Cancer research 2014 Jun 1;74(11):3127-36
PINK1 deficiency sustains cell proliferation by reprogramming glucose metabolism through HIF1.
Requejo-Aguilar R, Lopez-Fabuel I, Fernandez E, Martins LM, Almeida A, Bolaños JP
Nature communications 2014 Jul 24;5:4514
Nature communications 2014 Jul 24;5:4514
C9ORF72, implicated in amytrophic lateral sclerosis and frontotemporal dementia, regulates endosomal trafficking.
Farg MA, Sundaramoorthy V, Sultana JM, Yang S, Atkinson RA, Levina V, Halloran MA, Gleeson PA, Blair IP, Soo KY, King AE, Atkin JD
Human molecular genetics 2014 Jul 1;23(13):3579-95
Human molecular genetics 2014 Jul 1;23(13):3579-95
Hydrostatic pressure enhances mitomycin C induced apoptosis in urothelial carcinoma cells.
Chen SK, Chung CA, Cheng YC, Huang CJ, Ruaan RC, Chen WY, Li C, Tsao CW, Hu WW, Chien CC
Urologic oncology 2014 Jan;32(1):26.e17-24
Urologic oncology 2014 Jan;32(1):26.e17-24
A cell-penetrating peptide based on the interaction between c-Src and connexin43 reverses glioma stem cell phenotype.
Gangoso E, Thirant C, Chneiweiss H, Medina JM, Tabernero A
Cell death & disease 2014 Jan 23;5(1):e1023
Cell death & disease 2014 Jan 23;5(1):e1023
A p38MAPK/MK2 signaling pathway leading to redox stress, cell death and ischemia/reperfusion injury.
Ashraf MI, Ebner M, Wallner C, Haller M, Khalid S, Schwelberger H, Koziel K, Enthammer M, Hermann M, Sickinger S, Soleiman A, Steger C, Vallant S, Sucher R, Brandacher G, Santer P, Dragun D, Troppmair J
Cell communication and signaling : CCS 2014 Jan 14;12:6
Cell communication and signaling : CCS 2014 Jan 14;12:6
Depletion of extracellular signal-regulated kinase 1 in mice with cardiomyopathy caused by lamin A/C gene mutation partially prevents pathology before isoenzyme activation.
Wu W, Iwata S, Homma S, Worman HJ, Muchir A
Human molecular genetics 2014 Jan 1;23(1):1-11
Human molecular genetics 2014 Jan 1;23(1):1-11
Deletion of MAP2K2/MEK2: a novel mechanism for a RASopathy?
Nowaczyk MJ, Thompson BA, Zeesman S, Moog U, Sanchez-Lara PA, Magoulas PL, Falk RE, Hoover-Fong JE, Batista DA, Amudhavalli SM, White SM, Graham GE, Rauen KA
Clinical genetics 2014 Feb;85(2):138-46
Clinical genetics 2014 Feb;85(2):138-46
Steroidogenic factor 1 promotes aggressive growth of castration-resistant prostate cancer cells by stimulating steroid synthesis and cell proliferation.
Lewis SR, Hedman CJ, Ziegler T, Ricke WA, Jorgensen JS
Endocrinology 2014 Feb;155(2):358-69
Endocrinology 2014 Feb;155(2):358-69
Abnormal Ras signaling in Costello syndrome (CS) negatively regulates enamel formation.
Goodwin AF, Tidyman WE, Jheon AH, Sharir A, Zheng X, Charles C, Fagin JA, McMahon M, Diekwisch TG, Ganss B, Rauen KA, Klein OD
Human molecular genetics 2014 Feb 1;23(3):682-92
Human molecular genetics 2014 Feb 1;23(3):682-92
St8sia2 deficiency plus juvenile cannabis exposure in mice synergistically affect higher cognition in adulthood.
Tantra M, Kröcher T, Papiol S, Winkler D, Röckle I, Jatho J, Burkhardt H, Ronnenberg A, Gerardy-Schahn R, Ehrenreich H, Hildebrandt H
Behavioural brain research 2014 Dec 15;275:166-75
Behavioural brain research 2014 Dec 15;275:166-75
Pax6 is essential for the maintenance and multi-lineage differentiation of neural stem cells, and for neuronal incorporation into the adult olfactory bulb.
Curto GG, Nieto-Estévez V, Hurtado-Chong A, Valero J, Gómez C, Alonso JR, Weruaga E, Vicario-Abejón C
Stem cells and development 2014 Dec 1;23(23):2813-30
Stem cells and development 2014 Dec 1;23(23):2813-30
Argininosuccinate lyase in enterocytes protects from development of necrotizing enterocolitis.
Premkumar MH, Sule G, Nagamani SC, Chakkalakal S, Nordin A, Jain M, Ruan MZ, Bertin T, Dawson B, Zhang J, Schady D, Bryan NS, Campeau PM, Erez A, Lee B
American journal of physiology. Gastrointestinal and liver physiology 2014 Aug 1;307(3):G347-54
American journal of physiology. Gastrointestinal and liver physiology 2014 Aug 1;307(3):G347-54
Norovirus translation requires an interaction between the C Terminus of the genome-linked viral protein VPg and eukaryotic translation initiation factor 4G.
Chung L, Bailey D, Leen EN, Emmott EP, Chaudhry Y, Roberts LO, Curry S, Locker N, Goodfellow IG
The Journal of biological chemistry 2014 Aug 1;289(31):21738-50
The Journal of biological chemistry 2014 Aug 1;289(31):21738-50
Human cell growth regulator Ly-1 antibody reactive homologue accelerates processing of preribosomal RNA.
Miyazawa N, Yoshikawa H, Magae S, Ishikawa H, Izumikawa K, Terukina G, Suzuki A, Nakamura-Fujiyama S, Miura Y, Hayano T, Komatsu W, Isobe T, Takahashi N
Genes to cells : devoted to molecular & cellular mechanisms 2014 Apr;19(4):273-86
Genes to cells : devoted to molecular & cellular mechanisms 2014 Apr;19(4):273-86
Impaired autophagic flux is associated with increased endoplasmic reticulum stress during the development of NAFLD.
González-Rodríguez A, Mayoral R, Agra N, Valdecantos MP, Pardo V, Miquilena-Colina ME, Vargas-Castrillón J, Lo Iacono O, Corazzari M, Fimia GM, Piacentini M, Muntané J, Boscá L, García-Monzón C, Martín-Sanz P, Valverde ÁM
Cell death & disease 2014 Apr 17;5(4):e1179
Cell death & disease 2014 Apr 17;5(4):e1179
microRNA-22 promotes heart failure through coordinate suppression of PPAR/ERR-nuclear hormone receptor transcription.
Gurha P, Wang T, Larimore AH, Sassi Y, Abreu-Goodger C, Ramirez MO, Reddy AK, Engelhardt S, Taffet GE, Wehrens XH, Entman ML, Rodriguez A
PloS one 2013;8(9):e75882
PloS one 2013;8(9):e75882
Increased serum and musculotendinous fibrogenic proteins following persistent low-grade inflammation in a rat model of long-term upper extremity overuse.
Gao HG, Fisher PW, Lambi AG, Wade CK, Barr-Gillespie AE, Popoff SN, Barbe MF
PloS one 2013;8(8):e71875
PloS one 2013;8(8):e71875
Glycogen synthase kinase-3 inhibition enhances translation of pluripotency-associated transcription factors to contribute to maintenance of mouse embryonic stem cell self-renewal.
Sanchez-Ripoll Y, Bone HK, Owen T, Guedes AM, Abranches E, Kumpfmueller B, Spriggs RV, Henrique D, Welham MJ
PloS one 2013;8(4):e60148
PloS one 2013;8(4):e60148
Distinct roles of molecular chaperones HSP90α and HSP90β in the biogenesis of KCNQ4 channels.
Gao Y, Yechikov S, Vazquez AE, Chen D, Nie L
PloS one 2013;8(2):e57282
PloS one 2013;8(2):e57282
Polychlorinated biphenyls impair dibutyryl cAMP-induced astrocytic differentiation in rat C6 glial cell line.
Adornetto A, Pagliara V, Renzo GD, Arcone R
FEBS open bio 2013;3:459-66
FEBS open bio 2013;3:459-66
Kidney tubular β-catenin signaling controls interstitial fibroblast fate via epithelial-mesenchymal communication.
Zhou D, Tan RJ, Zhou L, Li Y, Liu Y
Scientific reports 2013;3:1878
Scientific reports 2013;3:1878
Yueju pill rapidly induces antidepressant-like effects and acutely enhances BDNF expression in mouse brain.
Xue W, Zhou X, Yi N, Jiang L, Tao W, Wu R, Wang D, Jiang J, Ge X, Wang Y, Wu H, Chen G
Evidence-based complementary and alternative medicine : eCAM 2013;2013:184367
Evidence-based complementary and alternative medicine : eCAM 2013;2013:184367
Interaction of PICK1 with C-terminus of growth hormone-releasing hormone receptor (GHRHR) modulates trafficking and signal transduction of human GHRHR.
Katsushima Y, Sato T, Yamada C, Ito M, Suzuki Y, Ogawa E, Sukegawa I, Sukegawa J, Fukunaga K, Yanagisawa T
Journal of pharmacological sciences 2013;122(3):193-204
Journal of pharmacological sciences 2013;122(3):193-204
Hsp90 inhibitor 17-DMAG decreases expression of conserved herpesvirus protein kinases and reduces virus production in Epstein-Barr virus-infected cells.
Sun X, Bristol JA, Iwahori S, Hagemeier SR, Meng Q, Barlow EA, Fingeroth JD, Tarakanova VL, Kalejta RF, Kenney SC
Journal of virology 2013 Sep;87(18):10126-38
Journal of virology 2013 Sep;87(18):10126-38
Activation of hepatocyte growth factor receptor, c-met, in renal tubules is required for renoprotection after acute kidney injury.
Zhou D, Tan RJ, Lin L, Zhou L, Liu Y
Kidney international 2013 Sep;84(3):509-20
Kidney international 2013 Sep;84(3):509-20
Identification and characterization of a novel human methyltransferase modulating Hsp70 protein function through lysine methylation.
Jakobsson ME, Moen A, Bousset L, Egge-Jacobsen W, Kernstock S, Melki R, Falnes PØ
The Journal of biological chemistry 2013 Sep 27;288(39):27752-63
The Journal of biological chemistry 2013 Sep 27;288(39):27752-63
Tumor protein D52 represents a negative regulator of ATM protein levels.
Chen Y, Kamili A, Hardy JR, Groblewski GE, Khanna KK, Byrne JA
Cell cycle (Georgetown, Tex.) 2013 Sep 15;12(18):3083-97
Cell cycle (Georgetown, Tex.) 2013 Sep 15;12(18):3083-97
Conventional knockout of Tbc1d1 in mice impairs insulin- and AICAR-stimulated glucose uptake in skeletal muscle.
Dokas J, Chadt A, Nolden T, Himmelbauer H, Zierath JR, Joost HG, Al-Hasani H
Endocrinology 2013 Oct;154(10):3502-14
Endocrinology 2013 Oct;154(10):3502-14
RAF and antioxidants prevent cell death induction after growth factor abrogation through regulation of Bcl-2 proteins.
Koziel K, Smigelskaite J, Drasche A, Enthammer M, Ashraf MI, Khalid S, Troppmair J
Experimental cell research 2013 Oct 15;319(17):2728-38
Experimental cell research 2013 Oct 15;319(17):2728-38
Estrogen responsiveness of the TFIID subunit TAF4B in the normal mouse ovary and in ovarian tumors.
Wardell JR, Hodgkinson KM, Binder AK, Seymour KA, Korach KS, Vanderhyden BC, Freiman RN
Biology of reproduction 2013 Nov;89(5):116
Biology of reproduction 2013 Nov;89(5):116
Noncanonical NOTCH signaling limits self-renewal of human epithelial and induced pluripotent stem cells through ROCK activation.
Yugawa T, Nishino K, Ohno S, Nakahara T, Fujita M, Goshima N, Umezawa A, Kiyono T
Molecular and cellular biology 2013 Nov;33(22):4434-47
Molecular and cellular biology 2013 Nov;33(22):4434-47
Isolation of a novel thioflavin S-derived compound that inhibits BAG-1-mediated protein interactions and targets BRAF inhibitor-resistant cell lines.
Enthammer M, Papadakis ES, Salomé Gachet M, Deutsch M, Schwaiger S, Koziel K, Ashraf MI, Khalid S, Wolber G, Packham G, Cutress RI, Stuppner H, Troppmair J
Molecular cancer therapeutics 2013 Nov;12(11):2400-14
Molecular cancer therapeutics 2013 Nov;12(11):2400-14
Human cytomegalovirus chemokine receptor US28 induces migration of cells on a CX3CL1-presenting surface.
Hjortø GM, Kiilerich-Pedersen K, Selmeczi D, Kledal TN, Larsen NB
The Journal of general virology 2013 May;94(Pt 5):1111-1120
The Journal of general virology 2013 May;94(Pt 5):1111-1120
Chromosome movements promoted by the mitochondrial protein SPD-3 are required for homology search during Caenorhabditis elegans meiosis.
Labrador L, Barroso C, Lightfoot J, Müller-Reichert T, Flibotte S, Taylor J, Moerman DG, Villeneuve AM, Martinez-Perez E
PLoS genetics 2013 May;9(5):e1003497
PLoS genetics 2013 May;9(5):e1003497
Persistent fibrosis in the liver of choline-deficient and iron-supplemented L-amino acid-defined diet-induced nonalcoholic steatohepatitis rat due to continuing oxidative stress after choline supplementation.
Takeuchi-Yorimoto A, Noto T, Yamada A, Miyamae Y, Oishi Y, Matsumoto M
Toxicology and applied pharmacology 2013 May 1;268(3):264-77
Toxicology and applied pharmacology 2013 May 1;268(3):264-77
Mitochondrial DNA (mtDNA) in brain samples from patients with major psychiatric disorders: gene expression profiles, mtDNA content and presence of the mtDNA common deletion.
Torrell H, Montaña E, Abasolo N, Roig B, Gaviria AM, Vilella E, Martorell L
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2013 Mar;162B(2):213-23
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics 2013 Mar;162B(2):213-23
N-cadherin expression is regulated by UTP in schwannoma cells.
Martiáñez T, Lamarca A, Casals N, Gella A
Purinergic signalling 2013 Jun;9(2):259-70
Purinergic signalling 2013 Jun;9(2):259-70
Cycloheximide inhibits follicle-stimulating hormone β subunit transcription by blocking de novo synthesis of the labile activin type II receptor in gonadotrope cells.
Rejon CA, Ho CC, Wang Y, Zhou X, Bernard DJ, Hébert TE
Cellular signalling 2013 Jun;25(6):1403-12
Cellular signalling 2013 Jun;25(6):1403-12
Surface proteins of C6/36 cells involved in dengue virus 4 binding and entry.
Vega-Almeida TO, Salas-Benito M, De Nova-Ocampo MA, Del Angel RM, Salas-Benito JS
Archives of virology 2013 Jun;158(6):1189-207
Archives of virology 2013 Jun;158(6):1189-207
α-1,6-Fucosyltransferase (FUT8) inhibits hemoglobin production during differentiation of murine and K562 human erythroleukemia cells.
Sasaki H, Toda T, Furukawa T, Mawatari Y, Takaesu R, Shimizu M, Wada R, Kato D, Utsugi T, Ohtsu M, Murakami Y
The Journal of biological chemistry 2013 Jun 7;288(23):16839-16847
The Journal of biological chemistry 2013 Jun 7;288(23):16839-16847
Monoclonal antibody against the ectodomain of E-cadherin (DECMA-1) suppresses breast carcinogenesis: involvement of the HER/PI3K/Akt/mTOR and IAP pathways.
Brouxhon SM, Kyrkanides S, Teng X, Raja V, O'Banion MK, Clarke R, Byers S, Silberfeld A, Tornos C, Ma L
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jun 15;19(12):3234-46
Clinical cancer research : an official journal of the American Association for Cancer Research 2013 Jun 15;19(12):3234-46
Cartilage oligomeric matrix protein enhances osteogenesis by directly binding and activating bone morphogenetic protein-2.
Ishida K, Acharya C, Christiansen BA, Yik JH, DiCesare PE, Haudenschild DR
Bone 2013 Jul;55(1):23-35
Bone 2013 Jul;55(1):23-35
Impaired surface expression and conductance of the KCNQ4 channel lead to sensorineural hearing loss.
Gao Y, Yechikov S, Vázquez AE, Chen D, Nie L
Journal of cellular and molecular medicine 2013 Jul;17(7):889-900
Journal of cellular and molecular medicine 2013 Jul;17(7):889-900
Gene regulatory network of unfolded protein response genes in endoplasmic reticulum stress.
Takayanagi S, Fukuda R, Takeuchi Y, Tsukada S, Yoshida K
Cell stress & chaperones 2013 Jan;18(1):11-23
Cell stress & chaperones 2013 Jan;18(1):11-23
SnoN/SKIL modulates proliferation through control of hsa-miR-720 transcription in esophageal cancer cells.
Shinozuka E, Miyashita M, Mizuguchi Y, Akagi I, Kikuchi K, Makino H, Matsutani T, Hagiwara N, Nomura T, Uchida E, Takizawa T
Biochemical and biophysical research communications 2013 Jan 4;430(1):101-6
Biochemical and biophysical research communications 2013 Jan 4;430(1):101-6
Wild-type and mutant p53 mediate cisplatin resistance through interaction and inhibition of active caspase-9.
Chee JL, Saidin S, Lane DP, Leong SM, Noll JE, Neilsen PM, Phua YT, Gabra H, Lim TM
Cell cycle (Georgetown, Tex.) 2013 Jan 15;12(2):278-88
Cell cycle (Georgetown, Tex.) 2013 Jan 15;12(2):278-88
Basolateral targeting and microtubule-dependent transcytosis of the aquaporin-2 water channel.
Yui N, Lu HA, Chen Y, Nomura N, Bouley R, Brown D
American journal of physiology. Cell physiology 2013 Jan 1;304(1):C38-48
American journal of physiology. Cell physiology 2013 Jan 1;304(1):C38-48
Differential glial activation during the degeneration of Purkinje cells and mitral cells in the PCD mutant mice.
Baltanás FC, Berciano MT, Valero J, Gómez C, Díaz D, Alonso JR, Lafarga M, Weruaga E
Glia 2013 Feb;61(2):254-72
Glia 2013 Feb;61(2):254-72
Distinct roles for ROCK1 and ROCK2 in the regulation of cell detachment.
Shi J, Wu X, Surma M, Vemula S, Zhang L, Yang Y, Kapur R, Wei L
Cell death & disease 2013 Feb 7;4(2):e483
Cell death & disease 2013 Feb 7;4(2):e483
Cellular and extracellular matrix changes in anterior cruciate ligaments during human knee aging and osteoarthritis.
Hasegawa A, Nakahara H, Kinoshita M, Asahara H, Koziol J, Lotz MK
Arthritis research & therapy 2013 Feb 14;15(1):R29
Arthritis research & therapy 2013 Feb 14;15(1):R29
Contrasting roles of mitogen-activated protein kinases in cellular entry and replication of hepatitis C virus: MKNK1 facilitates cell entry.
Kim S, Ishida H, Yamane D, Yi M, Swinney DC, Foung S, Lemon SM
Journal of virology 2013 Apr;87(8):4214-24
Journal of virology 2013 Apr;87(8):4214-24
c-Maf Transcription Factor Regulates ADAMTS-12 Expression in Human Chondrogenic Cells.
Hong E, Yik J, Amanatullah DF, Di Cesare PE, Haudenschild DR
Cartilage 2013 Apr;4(2):177-86
Cartilage 2013 Apr;4(2):177-86
p53 regulates epithelial-mesenchymal transition induced by transforming growth factor β.
Termén S, Tan EJ, Heldin CH, Moustakas A
Journal of cellular physiology 2013 Apr;228(4):801-13
Journal of cellular physiology 2013 Apr;228(4):801-13
In vivo analysis of kallikrein-related peptidase 6 (KLK6) function in oligodendrocyte development and the expression of myelin proteins.
Murakami K, Jiang YP, Tanaka T, Bando Y, Mitrovic B, Yoshida S
Neuroscience 2013 Apr 16;236:1-11
Neuroscience 2013 Apr 16;236:1-11
Histone h1 depletion impairs embryonic stem cell differentiation.
Zhang Y, Cooke M, Panjwani S, Cao K, Krauth B, Ho PY, Medrzycki M, Berhe DT, Pan C, McDevitt TC, Fan Y
PLoS genetics 2012;8(5):e1002691
PLoS genetics 2012;8(5):e1002691
Forced expression of miR-143 represses ERK5/c-Myc and p68/p72 signaling in concert with miR-145 in gut tumors of Apc(Min) mice.
Takaoka Y, Shimizu Y, Hasegawa H, Ouchi Y, Qiao S, Nagahara M, Ichihara M, Lee JD, Adachi K, Hamaguchi M, Iwamoto T
PloS one 2012;7(8):e42137
PloS one 2012;7(8):e42137
Mitochondrial physiology and gene expression analyses reveal metabolic and translational dysregulation in oocyte-induced somatic nuclear reprogramming.
Esteves TC, Psathaki OE, Pfeiffer MJ, Balbach ST, Zeuschner D, Shitara H, Yonekawa H, Siatkowski M, Fuellen G, Boiani M
PloS one 2012;7(6):e36850
PloS one 2012;7(6):e36850
Human ALKBH4 interacts with proteins associated with transcription.
Bjørnstad LG, Meza TJ, Otterlei M, Olafsrud SM, Meza-Zepeda LA, Falnes PØ
PloS one 2012;7(11):e49045
PloS one 2012;7(11):e49045
Uncovering suitable reference proteins for expression studies in human adipose tissue with relevance to obesity.
Pérez-Pérez R, López JA, García-Santos E, Camafeita E, Gómez-Serrano M, Ortega-Delgado FJ, Ricart W, Fernández-Real JM, Peral B
PloS one 2012;7(1):e30326
PloS one 2012;7(1):e30326
A novel role for BDNF-TrkB in the regulation of chemotherapy resistance in head and neck squamous cell carcinoma.
Lee J, Jiffar T, Kupferman ME
PloS one 2012;7(1):e30246
PloS one 2012;7(1):e30246
Tubule-specific ablation of endogenous β-catenin aggravates acute kidney injury in mice.
Zhou D, Li Y, Lin L, Zhou L, Igarashi P, Liu Y
Kidney international 2012 Sep;82(5):537-47
Kidney international 2012 Sep;82(5):537-47
The estrogen-responsive Agr2 gene regulates mammary epithelial proliferation and facilitates lobuloalveolar development.
Verma S, Salmans ML, Geyfman M, Wang H, Yu Z, Lu Z, Zhao F, Lipkin SM, Andersen B
Developmental biology 2012 Sep 15;369(2):249-60
Developmental biology 2012 Sep 15;369(2):249-60
Role of caspases in cytokine-induced barrier breakdown in human brain endothelial cells.
Lopez-Ramirez MA, Fischer R, Torres-Badillo CC, Davies HA, Logan K, Pfizenmaier K, Male DK, Sharrack B, Romero IA
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):3130-9
Journal of immunology (Baltimore, Md. : 1950) 2012 Sep 15;189(6):3130-9
Glut1 deficiency (G1D): epilepsy and metabolic dysfunction in a mouse model of the most common human phenotype.
Marin-Valencia I, Good LB, Ma Q, Duarte J, Bottiglieri T, Sinton CM, Heilig CW, Pascual JM
Neurobiology of disease 2012 Oct;48(1):92-101
Neurobiology of disease 2012 Oct;48(1):92-101
Human Pumilio proteins recruit multiple deadenylases to efficiently repress messenger RNAs.
Van Etten J, Schagat TL, Hrit J, Weidmann CA, Brumbaugh J, Coon JJ, Goldstrohm AC
The Journal of biological chemistry 2012 Oct 19;287(43):36370-83
The Journal of biological chemistry 2012 Oct 19;287(43):36370-83
Cardiomyocytes from AKAP7 knockout mice respond normally to adrenergic stimulation.
Jones BW, Brunet S, Gilbert ML, Nichols CB, Su T, Westenbroek RE, Scott JD, Catterall WA, McKnight GS
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 16;109(42):17099-104
Proceedings of the National Academy of Sciences of the United States of America 2012 Oct 16;109(42):17099-104
Distinct immunomodulatory effects of a panel of nanomaterials in human dermal fibroblasts.
Romoser AA, Figueroa DE, Sooresh A, Scribner K, Chen PL, Porter W, Criscitiello MF, Sayes CM
Toxicology letters 2012 May 5;210(3):293-301
Toxicology letters 2012 May 5;210(3):293-301
The transformation suppressor gene Reck is required for postaxial patterning in mouse forelimbs.
Yamamoto M, Matsuzaki T, Takahashi R, Adachi E, Maeda Y, Yamaguchi S, Kitayama H, Echizenya M, Morioka Y, Alexander DB, Yagi T, Itohara S, Nakamura T, Akiyama H, Noda M
Biology open 2012 May 15;1(5):458-66
Biology open 2012 May 15;1(5):458-66
Chronic IL-1β-mediated neuroinflammation mitigates amyloid pathology in a mouse model of Alzheimer's disease without inducing overt neurodegeneration.
Matousek SB, Ghosh S, Shaftel SS, Kyrkanides S, Olschowka JA, O'Banion MK
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Mar;7(1):156-64
Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology 2012 Mar;7(1):156-64
Genome-wide analysis of STAT3 binding in vivo predicts effectors of the anti-inflammatory response in macrophages.
Hutchins AP, Poulain S, Miranda-Saavedra D
Blood 2012 Mar 29;119(13):e110-9
Blood 2012 Mar 29;119(13):e110-9
Interactions between β-catenin and transforming growth factor-β signaling pathways mediate epithelial-mesenchymal transition and are dependent on the transcriptional co-activator cAMP-response element-binding protein (CREB)-binding protein (CBP).
Zhou B, Liu Y, Kahn M, Ann DK, Han A, Wang H, Nguyen C, Flodby P, Zhong Q, Krishnaveni MS, Liebler JM, Minoo P, Crandall ED, Borok Z
The Journal of biological chemistry 2012 Mar 2;287(10):7026-38
The Journal of biological chemistry 2012 Mar 2;287(10):7026-38
Abnormal platelet aggregation in idiopathic pulmonary arterial hypertension: role of nitric oxide.
Aytekin M, Aulak KS, Haserodt S, Chakravarti R, Cody J, Minai OA, Dweik RA
American journal of physiology. Lung cellular and molecular physiology 2012 Mar 15;302(6):L512-20
American journal of physiology. Lung cellular and molecular physiology 2012 Mar 15;302(6):L512-20
Beneficial effects of fenofibrate in retinal pigment epithelium by the modulation of stress and survival signaling under diabetic conditions.
Miranda S, González-Rodríguez Á, García-Ramírez M, Revuelta-Cervantes J, Hernández C, Simó R, Valverde ÁM
Journal of cellular physiology 2012 Jun;227(6):2352-62
Journal of cellular physiology 2012 Jun;227(6):2352-62
Agents that stabilize mutated von Hippel-Lindau (VHL) protein: results of a high-throughput screen to identify compounds that modulate VHL proteostasis.
Ding Z, German P, Bai S, Feng Z, Gao M, Si W, Sobieski MM, Stephan CC, Mills GB, Jonasch E
Journal of biomolecular screening 2012 Jun;17(5):572-80
Journal of biomolecular screening 2012 Jun;17(5):572-80
The imprinted H19 gene regulates human placental trophoblast cell proliferation via encoding miR-675 that targets Nodal Modulator 1 (NOMO1).
Gao WL, Liu M, Yang Y, Yang H, Liao Q, Bai Y, Li YX, Li D, Peng C, Wang YL
RNA biology 2012 Jul;9(7):1002-10
RNA biology 2012 Jul;9(7):1002-10
High basal γH2AX levels sustain self-renewal of mouse embryonic and induced pluripotent stem cells.
Turinetto V, Orlando L, Sanchez-Ripoll Y, Kumpfmueller B, Storm MP, Porcedda P, Minieri V, Saviozzi S, Accomasso L, Cibrario Rocchietti E, Moorwood K, Circosta P, Cignetti A, Welham MJ, Giachino C
Stem cells (Dayton, Ohio) 2012 Jul;30(7):1414-23
Stem cells (Dayton, Ohio) 2012 Jul;30(7):1414-23
MicroRNA-9 Modulates Hes1 ultradian oscillations by forming a double-negative feedback loop.
Bonev B, Stanley P, Papalopulu N
Cell reports 2012 Jul 26;2(1):10-8
Cell reports 2012 Jul 26;2(1):10-8
Temsirolimus activates autophagy and ameliorates cardiomyopathy caused by lamin A/C gene mutation.
Choi JC, Muchir A, Wu W, Iwata S, Homma S, Morrow JP, Worman HJ
Science translational medicine 2012 Jul 25;4(144):144ra102
Science translational medicine 2012 Jul 25;4(144):144ra102
Separase-dependent cleavage of pericentrin B is necessary and sufficient for centriole disengagement during mitosis.
Lee K, Rhee K
Cell cycle (Georgetown, Tex.) 2012 Jul 1;11(13):2476-85
Cell cycle (Georgetown, Tex.) 2012 Jul 1;11(13):2476-85
Mouse germ cell clusters form by aggregation as well as clonal divisions.
Mork L, Tang H, Batchvarov I, Capel B
Mechanisms of development 2012 Jan-Feb;128(11-12):591-6
Mechanisms of development 2012 Jan-Feb;128(11-12):591-6
A role for mDia, a Rho-regulated actin nucleator, in tangential migration of interneuron precursors.
Shinohara R, Thumkeo D, Kamijo H, Kaneko N, Sawamoto K, Watanabe K, Takebayashi H, Kiyonari H, Ishizaki T, Furuyashiki T, Narumiya S
Nature neuroscience 2012 Jan 15;15(3):373-80, S1-2
Nature neuroscience 2012 Jan 15;15(3):373-80, S1-2
Efficient synaptic vesicle recycling after intense exocytosis concomitant with the accumulation of non-releasable endosomes at early developmental stages.
Bartolomé-Martín D, Ramírez-Franco J, Castro E, Sánchez-Prieto J, Torres M
Journal of cell science 2012 Jan 15;125(Pt 2):422-34
Journal of cell science 2012 Jan 15;125(Pt 2):422-34
Changes in the serotonergic system and in brain-derived neurotrophic factor distribution in the main olfactory bulb of pcd mice before and after mitral cell loss.
Gómez C, Curto GG, Baltanás FC, Valero J, O'Shea E, Colado MI, Díaz D, Weruaga E, Alonso JR
Neuroscience 2012 Jan 10;201:20-33
Neuroscience 2012 Jan 10;201:20-33
Profiling of linker histone variants in ovarian cancer.
Medrzycki M, Zhang Y, McDonald JF, Fan Y
Frontiers in bioscience (Landmark edition) 2012 Jan 1;17(2):396-406
Frontiers in bioscience (Landmark edition) 2012 Jan 1;17(2):396-406
GRB2 interaction with the ecotropic murine leukemia virus receptor, mCAT-1, controls virus entry and is stimulated by virus binding.
Chen Z, Kolokoltsov AA, Wang J, Adhikary S, Lorinczi M, Elferink LA, Davey RA
Journal of virology 2012 Feb;86(3):1421-32
Journal of virology 2012 Feb;86(3):1421-32
Nestin expression is lost in ventricular fibroblasts during postnatal development of the rat heart and re-expressed in scar myofibroblasts.
Béguin PC, Gosselin H, Mamarbachi M, Calderone A
Journal of cellular physiology 2012 Feb;227(2):813-20
Journal of cellular physiology 2012 Feb;227(2):813-20
Mitochondrial stress engages E2F1 apoptotic signaling to cause deafness.
Raimundo N, Song L, Shutt TE, McKay SE, Cotney J, Guan MX, Gilliland TC, Hohuan D, Santos-Sacchi J, Shadel GS
Cell 2012 Feb 17;148(4):716-26
Cell 2012 Feb 17;148(4):716-26
AQP2 is necessary for vasopressin- and forskolin-mediated filamentous actin depolymerization in renal epithelial cells.
Yui N, Lu HJ, Bouley R, Brown D
Biology open 2012 Feb 15;1(2):101-8
Biology open 2012 Feb 15;1(2):101-8
Aurora kinase A inhibition-induced autophagy triggers drug resistance in breast cancer cells.
Zou Z, Yuan Z, Zhang Q, Long Z, Chen J, Tang Z, Zhu Y, Chen S, Xu J, Yan M, Wang J, Liu Q
Autophagy 2012 Dec;8(12):1798-810
Autophagy 2012 Dec;8(12):1798-810
Reduced connexin43 expression correlates with c-Src activation, proliferation, and glucose uptake in reactive astrocytes after an excitotoxic insult.
Gangoso E, Ezan P, Valle-Casuso JC, Herrero-González S, Koulakoff A, Medina JM, Giaume C, Tabernero A
Glia 2012 Dec;60(12):2040-9
Glia 2012 Dec;60(12):2040-9
The specificity protein factor Sp1 mediates transcriptional regulation of P2X7 receptors in the nervous system.
García-Huerta P, Díaz-Hernandez M, Delicado EG, Pimentel-Santillana M, Miras-Portugal MT, Gómez-Villafuertes R
The Journal of biological chemistry 2012 Dec 28;287(53):44628-44
The Journal of biological chemistry 2012 Dec 28;287(53):44628-44
Fragile X premutation RNA is sufficient to cause primary ovarian insufficiency in mice.
Lu C, Lin L, Tan H, Wu H, Sherman SL, Gao F, Jin P, Chen D
Human molecular genetics 2012 Dec 1;21(23):5039-47
Human molecular genetics 2012 Dec 1;21(23):5039-47
Progesterone regulation of progesterone receptor membrane component 1 (PGRMC1) sumoylation and transcriptional activity in spontaneously immortalized granulosa cells.
Peluso JJ, Lodde V, Liu X
Endocrinology 2012 Aug;153(8):3929-39
Endocrinology 2012 Aug;153(8):3929-39
The Rab-GTPase-activating protein TBC1D1 regulates skeletal muscle glucose metabolism.
Szekeres F, Chadt A, Tom RZ, Deshmukh AS, Chibalin AV, Björnholm M, Al-Hasani H, Zierath JR
American journal of physiology. Endocrinology and metabolism 2012 Aug 15;303(4):E524-33
American journal of physiology. Endocrinology and metabolism 2012 Aug 15;303(4):E524-33
Transcriptional induction of salt-inducible kinase 1 by transforming growth factor β leads to negative regulation of type I receptor signaling in cooperation with the Smurf2 ubiquitin ligase.
Lönn P, Vanlandewijck M, Raja E, Kowanetz M, Watanabe Y, Kowanetz K, Vasilaki E, Heldin CH, Moustakas A
The Journal of biological chemistry 2012 Apr 13;287(16):12867-78
The Journal of biological chemistry 2012 Apr 13;287(16):12867-78
Deficiency of mDia, an actin nucleator, disrupts integrity of neuroepithelium and causes periventricular dysplasia.
Thumkeo D, Shinohara R, Watanabe K, Takebayashi H, Toyoda Y, Tohyama K, Ishizaki T, Furuyashiki T, Narumiya S
PloS one 2011;6(9):e25465
PloS one 2011;6(9):e25465
NMDA mediated contextual conditioning changes miRNA expression.
Kye MJ, Neveu P, Lee YS, Zhou M, Steen JA, Sahin M, Kosik KS, Silva AJ
PloS one 2011;6(9):e24682
PloS one 2011;6(9):e24682
Akt1 is essential for postnatal mammary gland development, function, and the expression of Btn1a1.
LaRocca J, Pietruska J, Hixon M
PloS one 2011;6(9):e24432
PloS one 2011;6(9):e24432
Systematic analysis of gene expression differences between left and right atria in different mouse strains and in human atrial tissue.
Kahr PC, Piccini I, Fabritz L, Greber B, Schöler H, Scheld HH, Hoffmeier A, Brown NA, Kirchhof P
PloS one 2011;6(10):e26389
PloS one 2011;6(10):e26389
Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.
Žumer K, Plemenitaš A, Saksela K, Peterlin BM
Nucleic acids research 2011 Oct;39(18):7908-19
Nucleic acids research 2011 Oct;39(18):7908-19
Cell type-dependent gene regulation by Staufen2 in conjunction with Upf1.
Miki T, Kamikawa Y, Kurono S, Kaneko Y, Katahira J, Yoneda Y
BMC molecular biology 2011 Nov 16;12:48
BMC molecular biology 2011 Nov 16;12:48
C-terminus of heat shock cognate 70 interacting protein increases following stroke and impairs survival against acute oxidative stress.
Stankowski JN, Zeiger SL, Cohen EL, DeFranco DB, Cai J, McLaughlin B
Antioxidants & redox signaling 2011 May 15;14(10):1787-801
Antioxidants & redox signaling 2011 May 15;14(10):1787-801
Cyclin D1 inhibits mitochondrial activity in B cells.
Tchakarska G, Roussel M, Troussard X, Sola B
Cancer research 2011 Mar 1;71(5):1690-9
Cancer research 2011 Mar 1;71(5):1690-9
Nuclear and cytoplasmic LIMK1 enhances human breast cancer progression.
McConnell BV, Koto K, Gutierrez-Hartmann A
Molecular cancer 2011 Jun 18;10:75
Molecular cancer 2011 Jun 18;10:75
Regulation of the production of infectious genotype 1a hepatitis C virus by NS5A domain III.
Kim S, Welsch C, Yi M, Lemon SM
Journal of virology 2011 Jul;85(13):6645-56
Journal of virology 2011 Jul;85(13):6645-56
Loss of special AT-rich binding protein 1 expression is a marker of poor survival in lung cancer.
Selinger CI, Cooper WA, Al-Sohaily S, Mladenova DN, Pangon L, Kennedy CW, McCaughan BC, Stirzaker C, Kohonen-Corish MR
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011 Jul;6(7):1179-89
Journal of thoracic oncology : official publication of the International Association for the Study of Lung Cancer 2011 Jul;6(7):1179-89
Development of an Fn14 agonistic antibody as an anti-tumor agent.
Michaelson JS, Amatucci A, Kelly R, Su L, Garber E, Day ES, Berquist L, Cho S, Li Y, Parr M, Wille L, Schneider P, Wortham K, Burkly LC, Hsu YM, Joseph IB
mAbs 2011 Jul-Aug;3(4):362-75
mAbs 2011 Jul-Aug;3(4):362-75
KiSS1 mediates platinum sensitivity and metastasis suppression in head and neck squamous cell carcinoma.
Jiffar T, Yilmaz T, Lee J, Hanna E, El-Naggar A, Yu D, Myers JN, Kupferman ME
Oncogene 2011 Jul 14;30(28):3163-73
Oncogene 2011 Jul 14;30(28):3163-73
The molecular and cellular basis of variable craniofacial phenotypes and their genetic rescue in Twisted gastrulation mutant mice.
Billington CJ Jr, Ng B, Forsman C, Schmidt B, Bagchi A, Symer DE, Schotta G, Gopalakrishnan R, Sarver AL, Petryk A
Developmental biology 2011 Jul 1;355(1):21-31
Developmental biology 2011 Jul 1;355(1):21-31
Molecular mechanisms for activation of the agouti-related protein and stimulation of appetite.
Ilnytska O, Stütz AM, Park-York M, York DA, Ribnicky DM, Zuberi A, Cefalu WT, Argyropoulos G
Diabetes 2011 Jan;60(1):97-106
Diabetes 2011 Jan;60(1):97-106
Genetic analyses using a mouse cell cycle mutant identifies magoh as a novel gene involved in Cdk regulation.
Inaki M, Kato D, Utsugi T, Onoda F, Hanaoka F, Murakami Y
Genes to cells : devoted to molecular & cellular mechanisms 2011 Feb;16(2):166-78
Genes to cells : devoted to molecular & cellular mechanisms 2011 Feb;16(2):166-78
Load-reducing therapy prevents development of arrhythmogenic right ventricular cardiomyopathy in plakoglobin-deficient mice.
Fabritz L, Hoogendijk MG, Scicluna BP, van Amersfoorth SC, Fortmueller L, Wolf S, Laakmann S, Kreienkamp N, Piccini I, Breithardt G, Noppinger PR, Witt H, Ebnet K, Wichter T, Levkau B, Franke WW, Pieperhoff S, de Bakker JM, Coronel R, Kirchhof P
Journal of the American College of Cardiology 2011 Feb 8;57(6):740-50
Journal of the American College of Cardiology 2011 Feb 8;57(6):740-50
PINCH1 is transcriptional regulator in podocytes that interacts with WT1 and represses podocalyxin expression.
Wang D, Li Y, Wu C, Liu Y
PloS one 2011 Feb 24;6(2):e17048
PloS one 2011 Feb 24;6(2):e17048
Role of medium- and short-chain L-3-hydroxyacyl-CoA dehydrogenase in the regulation of body weight and thermogenesis.
Schulz N, Himmelbauer H, Rath M, van Weeghel M, Houten S, Kulik W, Suhre K, Scherneck S, Vogel H, Kluge R, Wiedmer P, Joost HG, Schürmann A
Endocrinology 2011 Dec;152(12):4641-51
Endocrinology 2011 Dec;152(12):4641-51
Loss of VOPP1 overexpression in squamous carcinoma cells induces apoptosis through oxidative cellular injury.
Baras AS, Solomon A, Davidson R, Moskaluk CA
Laboratory investigation; a journal of technical methods and pathology 2011 Aug;91(8):1170-80
Laboratory investigation; a journal of technical methods and pathology 2011 Aug;91(8):1170-80
Cell cholesterol modulates metalloproteinase-dependent shedding of low-density lipoprotein receptor-related protein-1 (LRP-1) and clearance function.
Selvais C, D'Auria L, Tyteca D, Perrot G, Lemoine P, Troeberg L, Dedieu S, Noël A, Nagase H, Henriet P, Courtoy PJ, Marbaix E, Emonard H
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Aug;25(8):2770-81
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2011 Aug;25(8):2770-81
A novel role for progesterone and progesterone receptor membrane component 1 in regulating spindle microtubule stability during rat and human ovarian cell mitosis.
Lodde V, Peluso JJ
Biology of reproduction 2011 Apr;84(4):715-22
Biology of reproduction 2011 Apr;84(4):715-22
Protein Tyrosine Phosphatase 1B (PTP1B) deficiency accelerates hepatic regeneration in mice.
Revuelta-Cervantes J, Mayoral R, Miranda S, González-Rodríguez A, Fernández M, Martín-Sanz P, Valverde AM
The American journal of pathology 2011 Apr;178(4):1591-604
The American journal of pathology 2011 Apr;178(4):1591-604
Endotoxin, zymosan, and cytokines decrease the expression of the transcription factor, carbohydrate response element binding protein, and its target genes.
Feingold KR, Shigenaga JK, Patzek SM, Chui LG, Moser A, Grunfeld C
Innate immunity 2011 Apr;17(2):174-82
Innate immunity 2011 Apr;17(2):174-82
PepT1 mediates transport of the proinflammatory bacterial tripeptide L-Ala-{gamma}-D-Glu-meso-DAP in intestinal epithelial cells.
Dalmasso G, Nguyen HT, Charrier-Hisamuddin L, Yan Y, Laroui H, Demoulin B, Sitaraman SV, Merlin D
American journal of physiology. Gastrointestinal and liver physiology 2010 Sep;299(3):G687-96
American journal of physiology. Gastrointestinal and liver physiology 2010 Sep;299(3):G687-96
Comparison of two dimensional electrophoresis mouse colon proteomes before and after knocking out Aquaporin 8.
Magdeldin S, Li H, Yoshida Y, Enany S, Zhang Y, Xu B, Fujinaka H, Yaoita E, Yamamoto T
Journal of proteomics 2010 Sep 10;73(10):2031-40
Journal of proteomics 2010 Sep 10;73(10):2031-40
Trpm4 differentially regulates Th1 and Th2 function by altering calcium signaling and NFAT localization.
Weber KS, Hildner K, Murphy KM, Allen PM
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 1;185(5):2836-46
Journal of immunology (Baltimore, Md. : 1950) 2010 Sep 1;185(5):2836-46
Reactive oxygen species control senescence-associated matrix metalloproteinase-1 through c-Jun-N-terminal kinase.
Dasgupta J, Kar S, Liu R, Joseph J, Kalyanaraman B, Remington SJ, Chen C, Melendez JA
Journal of cellular physiology 2010 Oct;225(1):52-62
Journal of cellular physiology 2010 Oct;225(1):52-62
Morphine- and CaMKII-dependent enhancement of GIRK channel signaling in hippocampal neurons.
Nassirpour R, Bahima L, Lalive AL, Lüscher C, Luján R, Slesinger PA
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 6;30(40):13419-30
The Journal of neuroscience : the official journal of the Society for Neuroscience 2010 Oct 6;30(40):13419-30
Progesterone inhibits apoptosis in part by PGRMC1-regulated gene expression.
Peluso JJ, Liu X, Gawkowska A, Lodde V, Wu CA
Molecular and cellular endocrinology 2010 May 14;320(1-2):153-61
Molecular and cellular endocrinology 2010 May 14;320(1-2):153-61
Cysteine 95 and other residues influence the regulatory effects of Histidine 69 mutations on Human Immunodeficiency Virus Type 1 protease autoprocessing.
Huang L, Hall A, Chen C
Retrovirology 2010 Mar 23;7:24
Retrovirology 2010 Mar 23;7:24
Murine norovirus-1 cell entry is mediated through a non-clathrin-, non-caveolae-, dynamin- and cholesterol-dependent pathway.
Gerondopoulos A, Jackson T, Monaghan P, Doyle N, Roberts LO
The Journal of general virology 2010 Jun;91(Pt 6):1428-38
The Journal of general virology 2010 Jun;91(Pt 6):1428-38
MicroRNA miR-137 regulates neuronal maturation by targeting ubiquitin ligase mind bomb-1.
Smrt RD, Szulwach KE, Pfeiffer RL, Li X, Guo W, Pathania M, Teng ZQ, Luo Y, Peng J, Bordey A, Jin P, Zhao X
Stem cells (Dayton, Ohio) 2010 Jun;28(6):1060-70
Stem cells (Dayton, Ohio) 2010 Jun;28(6):1060-70
Transforming growth factor beta promotes complexes between Smad proteins and the CCCTC-binding factor on the H19 imprinting control region chromatin.
Bergström R, Savary K, Morén A, Guibert S, Heldin CH, Ohlsson R, Moustakas A
The Journal of biological chemistry 2010 Jun 25;285(26):19727-37
The Journal of biological chemistry 2010 Jun 25;285(26):19727-37
Beta-arrestin 2 is required for B1 receptor-dependent post-translational activation of inducible nitric oxide synthase.
Kuhr FK, Zhang Y, Brovkovych V, Skidgel RA
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul;24(7):2475-83
FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2010 Jul;24(7):2475-83
Parkin is protective against proteotoxic stress in a transgenic zebrafish model.
Fett ME, Pilsl A, Paquet D, van Bebber F, Haass C, Tatzelt J, Schmid B, Winklhofer KF
PloS one 2010 Jul 30;5(7):e11783
PloS one 2010 Jul 30;5(7):e11783
Vascular endothelial growth factor receptors VEGFR-2 and VEGFR-3 are localized primarily to the vasculature in human primary solid cancers.
Smith NR, Baker D, James NH, Ratcliffe K, Jenkins M, Ashton SE, Sproat G, Swann R, Gray N, Ryan A, Jürgensmeier JM, Womack C
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 15;16(14):3548-61
Clinical cancer research : an official journal of the American Association for Cancer Research 2010 Jul 15;16(14):3548-61
Disruption of calvarial ossification in E2f4 mutant embryos correlates with increased proliferation and progenitor cell populations.
Miller ES, Berman SD, Yuan TL, Lees JA
Cell cycle (Georgetown, Tex.) 2010 Jul 1;9(13):2620-8
Cell cycle (Georgetown, Tex.) 2010 Jul 1;9(13):2620-8
MicroRNA-7 modulates CD98 expression during intestinal epithelial cell differentiation.
Nguyen HT, Dalmasso G, Yan Y, Laroui H, Dahan S, Mayer L, Sitaraman SV, Merlin D
The Journal of biological chemistry 2010 Jan 8;285(2):1479-89
The Journal of biological chemistry 2010 Jan 8;285(2):1479-89
Basic fibroblast growth factor elicits formation of interstitial axonal branches via enhanced severing of microtubules.
Qiang L, Yu W, Liu M, Solowska JM, Baas PW
Molecular biology of the cell 2010 Jan 15;21(2):334-44
Molecular biology of the cell 2010 Jan 15;21(2):334-44
Endothelial cells are susceptible to rapid siRNA transfection and gene silencing ex vivo.
Andersen ND, Chopra A, Monahan TS, Malek JY, Jain M, Pradhan L, Ferran C, LoGerfo FW
Journal of vascular surgery 2010 Dec;52(6):1608-15
Journal of vascular surgery 2010 Dec;52(6):1608-15
Role of sphingomyelin synthase in controlling the antimicrobial activity of neutrophils against Cryptococcus neoformans.
Qureshi A, Subathra M, Grey A, Schey K, Del Poeta M, Luberto C
PloS one 2010 Dec 28;5(12):e15587
PloS one 2010 Dec 28;5(12):e15587
The Chlamydia muridarum-induced IFN-β response is TLR3-dependent in murine oviduct epithelial cells.
Derbigny WA, Johnson RM, Toomey KS, Ofner S, Jayarapu K
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6689-97
Journal of immunology (Baltimore, Md. : 1950) 2010 Dec 1;185(11):6689-97
A novel screen using the Reck tumor suppressor gene promoter detects both conventional and metastasis-suppressing anticancer drugs.
Murai R, Yoshida Y, Muraguchi T, Nishimoto E, Morioka Y, Kitayama H, Kondoh S, Kawazoe Y, Hiraoka M, Uesugi M, Noda M
Oncotarget 2010 Aug;1(4):252-64
Oncotarget 2010 Aug;1(4):252-64
Cross talk between microRNA and epigenetic regulation in adult neurogenesis.
Szulwach KE, Li X, Smrt RD, Li Y, Luo Y, Lin L, Santistevan NJ, Li W, Zhao X, Jin P
The Journal of cell biology 2010 Apr 5;189(1):127-41
The Journal of cell biology 2010 Apr 5;189(1):127-41
Role of the cytoplasmic domain of the L1 cell adhesion molecule in brain development.
Nakamura Y, Lee S, Haddox CL, Weaver EJ, Lemmon VP
The Journal of comparative neurology 2010 Apr 1;518(7):1113-32
The Journal of comparative neurology 2010 Apr 1;518(7):1113-32
Intracellular signaling pathways control mitochondrial events associated with the development of ischemia/ reperfusion-associated damage.
Sucher R, Gehwolf P, Kaier T, Hermann M, Maglione M, Oberhuber R, Ratschiller T, Kuznetsov AV, Bösch F, Kozlov AV, Ashraf MI, Schneeberger S, Brandacher G, Ollinger R, Margreiter R, Troppmair J
Transplant international : official journal of the European Society for Organ Transplantation 2009 Sep;22(9):922-30
Transplant international : official journal of the European Society for Organ Transplantation 2009 Sep;22(9):922-30
C. elegans ATAD-3 is essential for mitochondrial activity and development.
Hoffmann M, Bellance N, Rossignol R, Koopman WJ, Willems PH, Mayatepek E, Bossinger O, Distelmaier F
PloS one 2009 Oct 30;4(10):e7644
PloS one 2009 Oct 30;4(10):e7644
Impaired PTPN13 phosphatase activity in spontaneous or HPV-induced squamous cell carcinomas potentiates oncogene signaling through the MAP kinase pathway.
Hoover AC, Strand GL, Nowicki PN, Anderson ME, Vermeer PD, Klingelhutz AJ, Bossler AD, Pottala JV, Hendriks WJ, Lee JH
Oncogene 2009 Nov 12;28(45):3960-70
Oncogene 2009 Nov 12;28(45):3960-70
Everolimus attenuates neointimal hyperplasia in cultured human saphenous vein grafts.
Semsroth S, Stigler RG, Bernecker OY, Ruttmann-Ulmer E, Troppmair J, Macfelda K, Bonatti JO, Laufer G
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2009 Mar;35(3):515-20
European journal of cardio-thoracic surgery : official journal of the European Association for Cardio-thoracic Surgery 2009 Mar;35(3):515-20
Molecular cloning and characterization of the common marmoset huntingtin gene.
Hohjoh H, Akari H, Fujiwara Y, Tamura Y, Hirai H, Wada K
Gene 2009 Mar 1;432(1-2):60-6
Gene 2009 Mar 1;432(1-2):60-6
Sp1 trans-activates the murine H(+)-K(+)-ATPase alpha(2)-subunit gene.
Yu Z, Li M, Zhang D, Xu W, Kone BC
American journal of physiology. Renal physiology 2009 Jul;297(1):F63-70
American journal of physiology. Renal physiology 2009 Jul;297(1):F63-70
KIF5B gene sequence variation and response of cardiac stroke volume to regular exercise.
Argyropoulos G, Stütz AM, Ilnytska O, Rice T, Teran-Garcia M, Rao DC, Bouchard C, Rankinen T
Physiological genomics 2009 Jan 8;36(2):79-88
Physiological genomics 2009 Jan 8;36(2):79-88
Binding of Silurus asotus lectin to Gb3 on Raji cells causes disappearance of membrane-bound form of HSP70.
Sugawara S, Kawano T, Omoto T, Hosono M, Tatsuta T, Nitta K
Biochimica et biophysica acta 2009 Feb;1790(2):101-9
Biochimica et biophysica acta 2009 Feb;1790(2):101-9
Age-dependent increases in interstitial collagenase and MAP Kinase levels are exacerbated by superoxide dismutase deficiencies.
Dasgupta J, Kar S, Van Remmen H, Melendez JA
Experimental gerontology 2009 Aug;44(8):503-10
Experimental gerontology 2009 Aug;44(8):503-10
Dynamic gene and protein expression patterns of the autism-associated met receptor tyrosine kinase in the developing mouse forebrain.
Judson MC, Bergman MY, Campbell DB, Eagleson KL, Levitt P
The Journal of comparative neurology 2009 Apr 10;513(5):511-31
The Journal of comparative neurology 2009 Apr 10;513(5):511-31
Arf GTPase-activating protein ASAP1 interacts with Rab11 effector FIP3 and regulates pericentrosomal localization of transferrin receptor-positive recycling endosome.
Inoue H, Ha VL, Prekeris R, Randazzo PA
Molecular biology of the cell 2008 Oct;19(10):4224-37
Molecular biology of the cell 2008 Oct;19(10):4224-37
Retinoic acid downregulates Rae1 leading to APC(Cdh1) activation and neuroblastoma SH-SY5Y differentiation.
Cuende J, Moreno S, Bolaños JP, Almeida A
Oncogene 2008 May 22;27(23):3339-44
Oncogene 2008 May 22;27(23):3339-44
Tripartite motif protein 32 facilitates cell growth and migration via degradation of Abl-interactor 2.
Kano S, Miyajima N, Fukuda S, Hatakeyama S
Cancer research 2008 Jul 15;68(14):5572-80
Cancer research 2008 Jul 15;68(14):5572-80
NHA-oc/NHA2: a mitochondrial cation-proton antiporter selectively expressed in osteoclasts.
Battaglino RA, Pham L, Morse LR, Vokes M, Sharma A, Odgren PR, Yang M, Sasaki H, Stashenko P
Bone 2008 Jan;42(1):180-92
Bone 2008 Jan;42(1):180-92
Molecular mechanism underlying differential apoptosis between human melanoma cell lines UACC903 and UACC903(+6) revealed by mitochondria-focused cDNA microarrays.
Zhang Q, Wu J, Nguyen A, Wang BD, He P, Laurent GS, Rennert OM, Su YA
Apoptosis : an international journal on programmed cell death 2008 Aug;13(8):993-1004
Apoptosis : an international journal on programmed cell death 2008 Aug;13(8):993-1004
Survival signaling by C-RAF: mitochondrial reactive oxygen species and Ca2+ are critical targets.
Kuznetsov AV, Smigelskaite J, Doblander C, Janakiraman M, Hermann M, Wurm M, Scheidl SF, Sucher R, Deutschmann A, Troppmair J
Molecular and cellular biology 2008 Apr;28(7):2304-13
Molecular and cellular biology 2008 Apr;28(7):2304-13
Inhibition of apoptotic potency by ligand stimulated thyroid hormone receptors located in mitochondria.
Saelim N, Holstein D, Chocron ES, Camacho P, Lechleiter JD
Apoptosis : an international journal on programmed cell death 2007 Oct;12(10):1781-94
Apoptosis : an international journal on programmed cell death 2007 Oct;12(10):1781-94
GATA3-driven Th2 responses inhibit TGF-beta1-induced FOXP3 expression and the formation of regulatory T cells.
Mantel PY, Kuipers H, Boyman O, Rhyner C, Ouaked N, Rückert B, Karagiannidis C, Lambrecht BN, Hendriks RW, Crameri R, Akdis CA, Blaser K, Schmidt-Weber CB
PLoS biology 2007 Dec;5(12):e329
PLoS biology 2007 Dec;5(12):e329
BMP suppresses PTEN expression via RAS/ERK signaling.
Beck SE, Carethers JM
Cancer biology & therapy 2007 Aug;6(8):1313-7
Cancer biology & therapy 2007 Aug;6(8):1313-7
Galectin-3 expression correlates with apoptosis of tumor-associated lymphocytes in human melanoma biopsies.
Zubieta MR, Furman D, Barrio M, Bravo AI, Domenichini E, Mordoh J
The American journal of pathology 2006 May;168(5):1666-75
The American journal of pathology 2006 May;168(5):1666-75
LMO4 can interact with Smad proteins and modulate transforming growth factor-beta signaling in epithelial cells.
Lu Z, Lam KS, Wang N, Xu X, Cortes M, Andersen B
Oncogene 2006 May 11;25(20):2920-30
Oncogene 2006 May 11;25(20):2920-30
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Supportive validation
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- Western blot analysis was performed on whole cell extracts (30µg lysate) of SH-SY5Y (Lane 1), COS-7 (Lane 2), MDCK (Lane 3), C2C12 (Lane 4), PC-3 (Lane 5), PC-12 (Lane 6), Neuro-2a (Lane 7), tissue extracts of Mouse Brain (Lane 8), Rat Testis (Lane 9), Mouse Pancreas (Lane 10) and Rat Heart (Lane 11). The blot was probed with Anti-GAPDH Mouse Monoclonal Antibody (Product # AM4300, 2µg/mL) and detected by chemiluminescence using Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, HRP conjugate (Product # A28177, 0.25µg/mL, 1:500 dilution). A 37 kDa band corresponding to GAPDH was observed across the cell lines and tissues tested. Known quantity of protein samples were electrophoresed using Novex® NuPAGE®12 % Bis-Tris gel (Product # NP0342BOX), XCell SureLock™ Electrophoresis System (Product # EI0002) and Novex® Sharp Pre-Stained Protein Standard (Product # LC5800). Resolved proteins were then transferred onto a nitrocellulose membrane with iBlot® 2 Dry Blotting System (Product # IB21001). The membrane was probed with the relevant primary and secondary Antibody following blocking with 5 % skimmed milk. Chemiluminescent detection was performed using Pierce™ ECL Western Blotting Substrate (Product # 32106).
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- An siRNA targeting ß-actin was labeled with Cy™3 using the Silencer™ siRNA Labeling Kit. The labeled siRNA was transfected into HeLa cells and cells were analyzed 96 hours later. Green: ß-actin protein detected with anti-ß-actin (Ambion) and a FITC labeled secondary antibody. Red: Cy3 labeled siRNA. Blue: DAPI stained nuclei. (Cy™3 is a trademark of Amersham Biosciences.)
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- Immunofluorescence analysis of GAPDH was done on 70% confluent log phase HeLa cells. The cells were fixed with 4% paraformaldehyde for 15 minutes, permeabilized with 0.25% Triton™ X-100 for 10 minutes, and blocked with 5% BSA for 1 hour at room temperature. The cells were labeled with GAPDH Mouse Monoclonal Antibody (Product # AM4300) at 1 µg/mL in 1% BSA and incubated for 3 hours at room temperature and then labeled with Goat anti-Mouse IgG (H+L) Superclonal™ Secondary Antibody, Alexa Fluor® 488 conjugate (Product # A28175) at a dilution of 1:2000 for 45 minutes at room temperature (Panel a: green). Nuclei (Panel b: blue) were stained with SlowFade® Gold Antifade Mountant with DAPI (Product # S36938). F-actin (Panel c: red) was stained with Alexa Fluor® 555 Rhodamine Phalloidin (Product # R415, 1:300). Panel d is a merged image showing perinuclear and cytoplasmic localization. Panel e is a no primary antibody control. The images were captured at 60X magnification.
Supportive validation
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- Fig. 1 TGFbeta regulates LXRalpha expression in the mesenchymal cell line Snu449 a Hep3B (left) and Snu449 (right) cells were treated with the indicated compounds (10 muM) and TGFbeta1 (5 ng/ml) for 24 h. The TGFbeta type I receptor kinase inhibitor LY2157299 was added at a final concentration of 2 muM for 24 h as a potent positive control. The expression of the indicated proteins was analyzed by immunoblotting. Experiments performed in biological duplicate. Densitometric quantification is provided below each lane. Results indicated as
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- Figure 4 GFP-LIMK1 fusions increase phosphorylation status of FAK signaling components . (A) Western blot analysis of whole cell lysates from MDA-MB-231 stable transductants probed with antibodies against pFAK, total FAK, pPaxillin, total Paxillin, pSrc, total Src, pAKT, total AKT, pErk1/2 and total Erk 1/2. (B) Western blot analysis for tubulin or GAPDH for each extract used in panel A, as loading controls.
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- Fig 4 Increased apoptosis underlies the nol11 cartilage defects. A) nol11 knockdown results in a progressive increase in apoptosis. At stage 14 no significant difference was observed in rates of TUNEL staining between knockdown and control halves of the embryo. At stages 18 and 28 increased apoptosis was evident on the treated side of whole mount and sectioned paraffin embedded embryos. Note that this increased apoptosis occurs primarily within the craniofacial ectomesenchyme. The graph represents the relative quantification of apoptosis rates at stages 14, 18 and 28. This stage specific increase in apoptosis was confirmed by a similar increase in p53 protein levels in 1 cell injected embryos as assayed by western blot (lower right panel). Dotted red lines mark the embryonic midline. B) No significant change in proliferation rates was noted following nol11 knockdown. C) Inhibition of apoptosis by p53 MO results in a partial rescue of cartilage size and morphology. Each pair of columns in the graph compares cartilage size measured in bilateral halves of embryos. The blue pair reveals no significant difference in cartilage measurements in the left vs right side of the UC embryonic head. In the second pair (red), cartilage size is seen to be comparable on either side of the nol11 morphant head. The final pair illustrates that cartilage size is significantly improved on the side of nol11 morphants rescued with p53 MO (green) relative to the side that received nol11 MO only (red).
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- Fig 5 Nol11 depletion impairs rDNA transcription and pre-rRNA processing in X . tropicalis . A) Scheme of pre-rRNA processing pathways in X tropicalis . The pre-rRNA is transcribed by RNAPI as a 40S polycistronic precursor. Several cleavages are required to separate the mature rRNAs. The locations of oligonucleotide probes used for northern blots are indicated by lettered lines (a, c) and the cleavage sites indicated. This scheme was adapted from [ 71 - 75 ]. B) Morpholino (MO) depletion of Nol11 impairs pre-rRNA transcription at stage 28. The northern blot was hybridized with probe a (Fig. 5A) and with a probe to the 7SL RNA as a loading control (lower panel). Bands were quantified and analysed by RAMP ([ 60 ]; S6A,B Fig ) C) Morpholino (MO) depletion of Nol11 impairs pre-rRNA transcription and processing. The northern blot was hybridized with probe c (Fig. 5A) and with a probe to the 7SL RNA as a loading control (lower panel). Bands were quantified and analysed by RAMP ([ 60 ]; S6C,D, E, F Fig ). D) Depletion of Nol11 leads to increased p53 levels. The expression of p53 from control and nol11 depleted embryos was analysed by western blot with anti-p53 antibodies. GAPDH levels were used as a loading control. Values for p53 expression normalized to GAPDH are represented in the bar graph. E) MO-resistant human NOL11 (hNOL11) mRNA but not p53 depletion rescues pre-rRNA levels. Embryos injected as shown by + and--in the figure at stages 22 and 28. The pre-rRNAs were visualized w
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- Figure 6. IFIT3 stabilizes and promotes IFIT1 activity in cells. ( A and B ) HEK293T cells were transfected with the indicated amounts of plasmid encoding FLAG-tagged versions of IFIT1, IFIT2 and IFIT3. After 24 hours cell lysates were harvested and analyzed by western blotting. (A) anti-FLAG and (B) anti-IFIT1 blots are shown. Empty vector was used to normalize the amount of DNA used in each transfection. The blots shown are representative of three separate experiments. ( C ) HEK293T cells were transfected with 1.5 mug of FLAG-tagged wild type (WT) or mutant IFIT1 and 1.5 mug of FLAG-tagged IFIT3 or empty vector as indicated. After 24 h cell lysates were analyzed as in A. The graph on right shows the quantification of the IFIT1 protein expression relative to GAPDH probed as a loading control. Mean +- the standard deviation of three biological repeats. ( D ) Reporter luciferase was measured as described in the Materials and Methods and expressed as the ratio of Fluc (cap0) over Nanoluc (cap1) signal, normalized to the empty vector control, and shown as the mean +- the standard deviation of three biological repeats. Statistical analysis was performed using an unpaired, two-tailed Students t-test. P -values are indicated, and * denotes statistical significance.
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- Figure S2 Generation of OTULIN-Targeted Mice, OTULIN Expression, Genotyping, and Reconstitution of Bone Marrow Chimeric Mice, Related to Figure 2 (A) Schematic showing the strategy to generate conditional and cell-type-specific knockouts of Otulin . SA, splice acceptor; neo, neomycin-resistance cassette; pA, polyA signal; PGK, murine PGK-1 promoter; DTA, diphtheria toxin A selection cassette; KanR, Kanamycin-resistance cassette. (B) Genotyping of mouse strains. PCR reactions showing the expected products from each genotype. (C) E13.5 embryos stained with X-gal for beta-galactosidase activity and cleared by methyl salicylate shows Otulin promoter activity in multiple tissues. Pictures are representative of five embryos of each genotype from two independent experiments. (D) Immunoblot analysis showing OTULIN expression in multiple tissues from adult wild-type C57BL/6 mice. Blots are representative of three independent experiments. (E) Ratio of CD45.1 + (wild-type B6.SJL) and CD45.2 + (CreERT2- Otulin +/flox or CreERT2- Otulin Lac Z/flox C57BL/6) expressing splenocytes determined by flow cytometry at the termination of chimera experiments. Data were pooled from two independent experiments. (F) Genotyping of bone marrow cells or blood leukocytes from CreERT2- Otulin flox chimeras treated with tamoxifen or vehicle shows complete or near-complete conversion of flox alleles to del alleles upon tamoxifen treatment. Note that WT(+) products are present in all reactions as BJ6.SJL WT c
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- Figure 2 Deletion of Otulin in Immune Cells Causes Acute Systemic Inflammation in Mice (A) OTULIN immunoblot on immune cells from wild-type mice. NK cell, natural killer cell; DC, dendritic cell; MPhi, macrophage. (B) Schematic representation of mixed bone marrow chimera generation. Wild-type (WT) B6.SJL cells are CD45.1 + , and CreERT2- Otulin flox cells are CD45.2 + . (C) Body weight following i.p. administration of tamoxifen (tx; arrows) to CreERT2- Otulin flox chimeric mice. (D) Neutrophil and lymphocyte counts from blood of CreERT2- Otulin flox chimeras and vehicle-treated controls at day 5 following tamoxifen administration. (E and F) Luminex multiplex analysis of serum cytokines and chemokines from terminal bleeds on day 5 presented as (E) a heatmap of relative changes in concentration of all analytes between CreERT2- Otulin +/flox and CreERT2- Otulin Lac Z/flox chimeras and (F) serum concentrations of cytokines and chemokines increased in CreERT2- Otulin Lac Z/flox chimeras. Data were pooled from two independent experiments. (G and H) Flow cytometry analysis of CD11b + Gr-1 + neutrophils in total cellular infiltrate (CD45.1 + and CD45.2 + ) in peritoneal lavage (PL), spleen, and liver from CreERT2- Otulin flox chimeras presented as (G) representative dot plots with percentage of cells in gate indicated and (H) total cell number. (I) Micrographs of hematoxylin and eosin (H&E) stained sections reveal inflammatory foci (arrowheads) in liver parenchyma. Micrographs are re
