sc-8330
antibody from Santa Cruz Biotechnology
Targeting: IKBKG
FIP-3, FIP3, Fip3p, IKK-gamma, IP1, IP2, NEMO, ZC2HC9
Antibody data
- Antibody Data
- Antigen structure
- References [9]
- Comments [0]
- Validations
- Western blot [1]
- Immunohistochemistry [1]
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Validation data
Reference
Comment
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- Product number
- sc-8330 - Provider product page
- Provider
- Santa Cruz Biotechnology
- Proper citation
- Santa Cruz Biotechnology Cat#sc-8330, RRID:AB_2124846
- Product name
- Anti-IKBKG
- Antibody type
- Polyclonal
- Antigen
- Recombinant full-length protein
- Reactivity
- Human
- Host
- Rabbit
Submitted references Epstein-Barr virus-encoded EBNA1 inhibits the canonical NF-kappaB pathway in carcinoma cells by inhibiting IKK phosphorylation.
NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.
Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.
Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia.
Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression.
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter.
Valentine R, Dawson CW, Hu C, Shah KM, Owen TJ, Date KL, Maia SP, Shao J, Arrand JR, Young LS, O'Neil JD
Molecular cancer 2010 Jan 5;9:1
Molecular cancer 2010 Jan 5;9:1
NEMO-binding domains of both IKKalpha and IKKbeta regulate IkappaB kinase complex assembly and classical NF-kappaB activation.
Solt LA, Madge LA, May MJ
The Journal of biological chemistry 2009 Oct 2;284(40):27596-608
The Journal of biological chemistry 2009 Oct 2;284(40):27596-608
Inactivation of NF-kappaB p50 leads to insulin sensitization in liver through post-translational inhibition of p70S6K.
Gao Z, Yin J, Zhang J, He Q, McGuinness OP, Ye J
The Journal of biological chemistry 2009 Jul 3;284(27):18368-76
The Journal of biological chemistry 2009 Jul 3;284(27):18368-76
Inflammation and NFkappaB activation is decreased by hypothermia following global cerebral ischemia.
Webster CM, Kelly S, Koike MA, Chock VY, Giffard RG, Yenari MA
Neurobiology of disease 2009 Feb;33(2):301-12
Neurobiology of disease 2009 Feb;33(2):301-12
Interleukin-1-induced NF-kappaB activation is NEMO-dependent but does not require IKKbeta.
Solt LA, Madge LA, Orange JS, May MJ
The Journal of biological chemistry 2007 Mar 23;282(12):8724-33
The Journal of biological chemistry 2007 Mar 23;282(12):8724-33
Key function for the Ubc13 E2 ubiquitin-conjugating enzyme in immune receptor signaling
Masahiro Yamamoto, Toru Okamoto, Kiyoshi Takeda, Shintaro Sato, Hideki Sanjo, Satoshi Uematsu, Tatsuya Saitoh, Naoki Yamamoto, Hiroaki Sakurai, Ken J Ishii, Shoji Yamaoka, Taro Kawai, Yoshiharu Matsuura, Osamu Takeuchi, Shizuo Akira
Nature Immunology 2006 Jul;7(9):962-970
Nature Immunology 2006 Jul;7(9):962-970
Positive and negative regulation of EAAT2 by NF-kappaB: a role for N-myc in TNFalpha-controlled repression.
Sitcheran R, Gupta P, Fisher PB, Baldwin AS
The EMBO journal 2005 Feb 9;24(3):510-20
The EMBO journal 2005 Feb 9;24(3):510-20
Deletion of IKK2 in hepatocytes does not sensitize these cells to TNF-induced apoptosis but protects from ischemia/reperfusion injury.
Luedde T, Assmus U, Wüstefeld T, Meyer zu Vilsendorf A, Roskams T, Schmidt-Supprian M, Rajewsky K, Brenner DA, Manns MP, Pasparakis M, Trautwein C
The Journal of clinical investigation 2005 Apr;115(4):849-59
The Journal of clinical investigation 2005 Apr;115(4):849-59
Activation of the NF-kappaB pathway in human cytomegalovirus-infected cells is necessary for efficient transactivation of the major immediate-early promoter.
DeMeritt IB, Milford LE, Yurochko AD
Journal of virology 2004 May;78(9):4498-507
Journal of virology 2004 May;78(9):4498-507
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Supportive validation
- Submitted by
- per
- Main image
- Experimental details
- Western blot analysis of antibody specificity using a routine panel composed of IgG/HSA-depleted human plasma and protein lysates from selected human tissues and cell lines.
- Validation comment
- Single band corresponding to the predicted size in kDa (+/-20%).
- Primary Ab dilution
- 1:500
- Secondary Ab dilution
- 1:3000
- Lane 1
- Marker [kDa]: 219, 111, 83, 48, 32, 26, 17
- Lane 2
- RT-4
- Lane 3
- U-251MG sp
- Lane 4
- Human Plasma
- Lane 5
- Liver
- Lane 6
- Tonsil
- Theoretical target weight
- [kDa] 56
Supportive validation
- Submitted by
- per
- Main image
- Experimental details
- Immunohistochemical staining of human tonsil shows strong cytoplasmic positivity in lymphoid cells outside reaction centra.
- Validation comment
- Staining pattern consistent with experimental and/or bioinformatic data.