Tissue expression
Cell line expression
Protein structure
SELENOH
Selenoprotein HC11orf31, SELH
This gene encodes a nucleolar protein, which belongs to the SelWTH family. It functions as an oxidoreductase, and has been shown to protect neurons against UVB-induced damage by inhibiting apoptotic cell death pathways, promote mitochondrial biogenesis and mitochondrial function, and suppress cellular senescence through genome maintenance and redox regulation. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec) at its active site. Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, May 2016]
Top validated antibodies |
|||||
Atlas Antibodies | HPA048362 | Polyclonal |
ICC
IHC |
||
Invitrogen Antibodies | PA5-61721 | Polyclonal |
ICC
IHC |
||
antibodies-online | ABIN4352480 | Polyclonal |
ICC
IHC |
||
Novus Biologicals | NBP2-14637 | Polyclonal |
ICC
IHC |
||
St John's Laboratory | STJ195998 | Polyclonal |
WB
|
All Antibodies
Filters
Enhanced validation
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider
Supportive data in Antibodypedia
Data presented on provider website
Data in Antibodypedia (inconclusive)
Recommended by provider