CD4

This gene encodes the CD4 membrane glycoprotein of T lymphocytes. The CD4 antigen acts as a coreceptor with the T-cell receptor on the T lymphocyte to recognize antigens displayed by an antigen presenting cell in the context of class II MHC molecules. The CD4 antigen is also a primary receptor for entry of the human immunodeficiency virus through interactions with the HIV Env gp120 subunit. This gene is expressed not only in T lymphocytes, but also in B cells, macrophages, granulocytes, as well as in various regions of the brain. The protein functions to initiate or augment the early phase of T-cell activation, and may function as an important mediator of indirect neuronal damage in infectious and immune-mediated diseases of the central nervous system. Multiple alternatively spliced transcript variants encoding different isoforms have been identified in this gene. [provided by RefSeq, May 2020]

Description

CD4 molecule

Tissue specificity

Tissue enhanced (liver, lymphoid tissue, parathyroid gland)

Subcell location

Plasma membrane

Predicted location

Intracellular, Membrane

Protein family

CD markers
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

12 (6786858 - 6820799)

Ensembl ID

ENSG00000010610  (ver. 103.38)

Orthologs

Mouse Cd4: ENSMUSG00000023274

UniProt

P01730

neXtProt

NX_P01730

Human splice variants
Mouse splice variants

Protein structure