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Protein structure
ABCC2
ATP binding cassette subfamily C member 2CMOAT, cMRP, DJS, MRP2
The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MRP subfamily which is involved in multi-drug resistance. This protein is expressed in the canalicular (apical) part of the hepatocyte and functions in biliary transport. Substrates include anticancer drugs such as vinblastine; therefore, this protein appears to contribute to drug resistance in mammalian cells. Several different mutations in this gene have been observed in patients with Dubin-Johnson syndrome (DJS), an autosomal recessive disorder characterized by conjugated hyperbilirubinemia. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-32687 |
1 references | Monoclonal |
WB
ICC
IHC
FC
OA
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| Proteintech Group | 24893-1-AP |
23 references | Polyclonal |
WB
EL
IHC
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| antibodies-online | ABIN4948190 |
5 references | Monoclonal |
WB
EL
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| Novus Biologicals | NBP2-66958 |
Monoclonal |
WB
ICC
IHC
FC
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| Boster Biological Technology | A00974 |
Polyclonal |
WB
ICC
IHC
FC
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