Tissue expression
Cell line expression
Protein structure
PPP1R12A
Protein phosphatase 1 regulatory subunit 12AM130, MBS, MYPT1
Myosin phosphatase target subunit 1, which is also called the myosin-binding subunit of myosin phosphatase, is one of the subunits of myosin phosphatase. Myosin phosphatase regulates the interaction of actin and myosin downstream of the guanosine triphosphatase Rho. The small guanosine triphosphatase Rho is implicated in myosin light chain (MLC) phosphorylation, which results in contraction of smooth muscle and interaction of actin and myosin in nonmuscle cells. The guanosine triphosphate (GTP)-bound, active form of RhoA (GTP.RhoA) specifically interacted with the myosin-binding subunit (MBS) of myosin phosphatase, which regulates the extent of phosphorylation of MLC. Rho-associated kinase (Rho-kinase), which is activated by GTP. RhoA, phosphorylated MBS and consequently inactivated myosin phosphatase. Overexpression of RhoA or activated RhoA in NIH 3T3 cells increased phosphorylation of MBS and MLC. Thus, Rho appears to inhibit myosin phosphatase through the action of Rho-kinase. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2009]
Top validated antibodies |
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Proteintech Group | 22117-1-AP | 7 references | Polyclonal |
WB
EL
ICC
IP
IHC
|
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Invitrogen Antibodies | 22117-1-AP | Polyclonal |
WB
ICC
IP
IHC
OA
|
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Boster Biological Technology | PB9737 | 3 references | Polyclonal |
WB
ICC
IHC
FC |
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NovoPro Bioscience Inc. | 113001 | Polyclonal |
WB
EL
ICC
IP
IHC
|
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OriGene | AP06544PU-N | 1 references | Polyclonal |
WB
EL
IHC
|
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