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Protein structure
TNK2
Tyrosine kinase non receptor 2ACK, ACK1, p21cdc42Hs
This gene encodes a tyrosine kinase that binds Cdc42Hs in its GTP-bound form and inhibits both the intrinsic and GTPase-activating protein (GAP)-stimulated GTPase activity of Cdc42Hs. This binding is mediated by a unique sequence of 47 amino acids C-terminal to an SH3 domain. The protein may be involved in a regulatory mechanism that sustains the GTP-bound active form of Cdc42Hs and which is directly linked to a tyrosine phosphorylation signal transduction pathway. Several alternatively spliced transcript variants have been identified from this gene, but the full-length nature of only two transcript variants has been determined. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Proteintech Group |  14304-1-AP |
1 references | Polyclonal |
WB
EL
IHC
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| LSBio | LS-C198587 |
Polyclonal |
WB
EL
ICC
IHC
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| antibodies-online | ABIN2841841 |
2 references | Polyclonal |
WB
IHC
FC
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| Aviva Systems Biology | OAAB04763 |
Polyclonal |
WB
EL
IHC
FC
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| Abnova Corporation | PAB3416 |
2 references | Polyclonal |
WB
IHC
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