SLC9A3R2

This gene encodes a member of the NHERF family of PDZ scaffolding proteins. These proteins mediate many cellular processes by binding to and regulating the membrane expression and protein-protein interactions of membrane receptors and transport proteins. The encoded protein plays a role in intestinal sodium absorption by regulating the activity of the sodium/hydrogen exchanger 3, and may also regulate the cystic fibrosis transmembrane regulator (CFTR) ion channel. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene. [provided by RefSeq, Nov 2011]

Description

SLC9A3 regulator 2

Tissue specificity

Low tissue specificity

Subcell location

Plasma membrane

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

16 (2025356 - 2039026)

Ensembl ID

ENSG00000065054  (ver. 103.38)

Orthologs

Mouse Slc9a3r2: ENSMUSG00000002504

UniProt

Q15599

neXtProt

NX_Q15599

Human splice variants
Mouse splice variants

Protein structure