NEO1

This gene encodes a cell surface protein that is a member of the immunoglobulin superfamily. The encoded protein consists of four N-terminal immunoglobulin-like domains, six fibronectin type III domains, a transmembrane domain and a C-terminal internal domain that shares homology with the tumor suppressor candidate gene DCC. This protein may be involved in cell growth and differentiation and in cell-cell adhesion. Defects in this gene are associated with cell proliferation in certain cancers. Alternate splicing results in multiple transcript variants. [provided by RefSeq, Feb 2010]

Description

Neogenin 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Golgi apparatus, Plasma membrane

Predicted location

Membrane

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (73051710 - 73305205)

Ensembl ID

ENSG00000067141  (ver. 103.38)

Orthologs

Mouse Neo1: ENSMUSG00000032340

UniProt

Q92859

neXtProt

NX_Q92859

Human splice variants
Mouse splice variants

Protein structure