TP53BP1

This gene encodes a protein that functions in the DNA double-strand break repair pathway choice, promoting non-homologous end joining (NHEJ) pathways, and limiting homologous recombination. This protein plays multiple roles in the DNA damage response, including promoting checkpoint signaling following DNA damage, acting as a scaffold for recruitment of DNA damage response proteins to damaged chromatin, and promoting NHEJ pathways by limiting end resection following a double-strand break. These roles are also important during V(D)J recombination, class switch recombination and at unprotected telomeres. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq, Aug 2017]

Description

Tumor protein p53 binding protein 1

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Nuclear bodies, Mitotic chromosome, Vesicles

Predicted location

Intracellular

Protein family

Cancer-related genes
Disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

15 (43403061 - 43510728)

Ensembl ID

ENSG00000067369  (ver. 103.38)

Orthologs

Mouse Trp53bp1: ENSMUSG00000043909

UniProt

Q12888

neXtProt

NX_Q12888

Human splice variants
Mouse splice variants

Protein structure