TRPM5

This gene encodes a member of the transient receptor potential (TRP) protein family, which is a diverse group of proteins with structural features typical of ion channels. This protein plays an important role in taste transduction, and has characteristics of a calcium-activated, non-selective cation channel that carries Na+, K+, and Cs+ ions equally well, but not Ca(2+) ions. It is activated by lower concentrations of intracellular Ca(2+), and inhibited by higher concentrations. It is also a highly temperature-sensitive, heat activated channel showing a steep increase of inward currents at temperatures between 15 and 35 degrees Celsius. This gene is located within the Beckwith-Wiedemann syndrome critical region-1 on chromosome 11p15.5, and has been shown to be imprinted, with exclusive expression from the paternal allele. [provided by RefSeq, Oct 2010]

Description

Transient receptor potential cation channel subfamily M member 5

Tissue specificity

Tissue enhanced (epididymis, intestine, pancreas, seminal vesicle)

Predicted location

Membrane

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted membrane proteins
Protein evidence (Kim et al 2014)
Transporters
Voltage-gated ion channels

Chromosome

11 (2404515 - 2423045)

Ensembl ID

ENSG00000070985  (ver. 103.38)

Orthologs

Mouse Trpm5: ENSMUSG00000009246

UniProt

Q9NZQ8

neXtProt

NX_Q9NZQ8

Human splice variants
Mouse splice variants

Protein structure