LIMS2

This gene encodes a member of a small family of focal adhesion proteins which interacts with ILK (integrin-linked kinase), a protein which effects protein-protein interactions with the extraceullar matrix. The encoded protein has five LIM domains, each domain forming two zinc fingers, which permit interactions which regulate cell shape and migration. A pseudogene of this gene is located on chromosome 4. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2011]

Description

LIM zinc finger domain containing 2

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Focal adhesion sites

Predicted location

Intracellular

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (127638381 - 127681786)

Ensembl ID

ENSG00000072163  (ver. 103.38)

Orthologs

Mouse Lims2: ENSMUSG00000024395

UniProt

Q7Z4I7

neXtProt

NX_Q7Z4I7

Human splice variants
Mouse splice variants

Protein structure