Tissue expression
Cell line expression
Protein structure
IRAG1
Inositol 1,4,5-triphosphate receptor associated 1IRAG, JAW1L, MRVI1
This gene is similar to a putative mouse tumor suppressor gene (Mrvi1) that is frequently disrupted by mouse AIDS-related virus (MRV). The encoded protein, which is found in the membrane of the endoplasmic reticulum, is similar to Jaw1, a lymphoid-restricted protein whose expression is down-regulated during lymphoid differentiation. This protein is a substrate of cGMP-dependent kinase-1 (PKG1) that can function as a regulator of IP3-induced calcium release. Studies in mouse suggest that MRV integration at Mrvi1 induces myeloid leukemia by altering the expression of a gene important for myeloid cell growth and/or differentiation, and thus this gene may function as a myeloid leukemia tumor suppressor gene. Several alternatively spliced transcript variants encoding different isoforms have been found for this gene, and alternative translation start sites, including a non-AUG (CUG) start site, are used. [provided by RefSeq, May 2011]
Top validated antibodies |
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antibodies-online | ABIN4327491 | Polyclonal |
WB
IHC |
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GeneTex | GTX123277 | Polyclonal |
WB
IHC |
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Atlas Antibodies | HPA008704 | Polyclonal |
ICC
IHC |
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Novus Biologicals | NBP2-16987 | Polyclonal |
WB
IHC |
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Invitrogen Antibodies | PA5-32111 | Polyclonal |
WB
IHC |
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Supportive data in Antibodypedia
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