SELENOO

This gene encodes a selenoprotein that is localized to the mitochondria. It is the largest mammalian selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. The exact function of this selenoprotein is not known, but it is thought to have redox activity. [provided by RefSeq, Dec 2016]

Description

Selenoprotein O

Tissue specificity

Tissue enhanced (liver)

Subcell location

Mitotic chromosome, Mitochondria

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (50200979 - 50217616)

Ensembl ID

ENSG00000073169  (ver. 103.38)

Orthologs

Mouse Selenoo: ENSMUSG00000035757

UniProt

Q9BVL4

neXtProt

NX_Q9BVL4

Human splice variants
Mouse splice variants

Protein structure