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Protein structure
TCF7
Transcription factor 7TCF-1
This gene encodes a member of the T-cell factor/lymphoid enhancer-binding factor family of high mobility group (HMG) box transcriptional activators. This gene is expressed predominantly in T-cells and plays a critical role in natural killer cell and innate lymphoid cell development. The encoded protein forms a complex with beta-catenin and activates transcription through a Wnt/beta-catenin signaling pathway. Mice with a knockout of this gene are viable and fertile, but display a block in T-lymphocyte differentiation. Alternative splicing results in multiple transcript variants. Naturally-occurring isoforms lacking the N-terminal beta-catenin interaction domain may act as dominant negative regulators of Wnt signaling. [provided by RefSeq, Oct 2016]
Top validated antibodies |
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| Invitrogen Antibodies |  MA5-14965 |
4 references | Monoclonal |
WB
ICC
IP
IHC
FC
OA
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| Novus Biologicals | H00006932-M01 |
1 references | Monoclonal |
WB
EL
ICC
IHC
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| Cell Signaling Technology, Inc | 2203 |
Monoclonal |
WB
ICC
IP
IHC
FC
ChIP
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| Proteintech Group | 14464-1-AP |
16 references | Polyclonal |
WB
EL
IHC
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| Abnova Corporation | H00006932-M01 |
Monoclonal |
WB
EL
ICC
IHC
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