FCN1

The ficolin family of proteins are characterized by the presence of a leader peptide, a short N-terminal segment, followed by a collagen-like region, and a C-terminal fibrinogen-like domain. The collagen-like and the fibrinogen-like domains are also found separately in other proteins such as complement protein C1q, C-type lectins known as collectins, and tenascins. However, all these proteins recognize different targets, and are functionally distinct. Ficolin 1 encoded by FCN1 is predominantly expressed in the peripheral blood leukocytes, and has been postulated to function as a plasma protein with elastin-binding activity. [provided by RefSeq, Jul 2008]

Description

Ficolin 1

Tissue specificity

Group enriched (bone marrow, lung, lymphoid tissue)

Predicted location

Membrane, Secreted to blood

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

9 (134903232 - 134917912)

Ensembl ID

ENSG00000085265  (ver. 103.38)

Orthologs

Mouse Fcnb: ENSMUSG00000026835

UniProt

O00602

neXtProt

NX_O00602

Human splice variants
Mouse splice variants

Protein structure