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Cell line expression
Protein structure
PILRA
Paired immunoglobin like type 2 receptor alphaFDF03
Cell signaling pathways rely on a dynamic interaction between activating and inhibiting processes. SHP-1-mediated dephosphorylation of protein tyrosine residues is central to the regulation of several cell signaling pathways. Two types of inhibitory receptor superfamily members are immunoreceptor tyrosine-based inhibitory motif (ITIM)-bearing receptors and their non-ITIM-bearing, activating counterparts. Control of cell signaling via SHP-1 is thought to occur through a balance between PILRalpha-mediated inhibition and PILRbeta-mediated activation. These paired immunoglobulin-like receptor genes are located in a tandem head-to-tail orientation on chromosome 7. This particular gene encodes the ITIM-bearing member of the receptor pair, which functions in the inhibitory role. Alternative splicing has been observed at this locus and three variants, each encoding a distinct isoform, are described. [provided by RefSeq, Jul 2008]
Top validated antibodies |
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| Novus Biologicals |  DDX0230P-100 |
5 references | Monoclonal |
WB
IP
FC
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| R&D Systems | MAB64841-100 |
Monoclonal |
WB
IHC
FC
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| antibodies-online | ABIN393682 |
Monoclonal |
WB
EL
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| Abnova Corporation | H00029992-M01 |
Monoclonal |
WB
EL
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| Invitrogen Antibodies | PA5-80901 |
Polyclonal |
WB
EL
IP
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