FAT2

This gene is the second identified human homolog of the Drosophila fat gene, which encodes a tumor suppressor essential for controlling cell proliferation during Drosophila development. The gene product is a member of the cadherin superfamily, a group of integral membrane proteins characterized by the presence of cadherin-type repeats. In addition to containing 34 tandem cadherin-type repeats, the gene product has two epidermal growth factor (EGF)-like repeats and one laminin G domain. This protein most likely functions as a cell adhesion molecule, controlling cell proliferation and playing an important role in cerebellum development. [provided by RefSeq, Jul 2008]

Description

FAT atypical cadherin 2

Tissue specificity

Tissue enhanced (brain, esophagus, skin)

Predicted location

Membrane

Protein family

Disease related genes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

5 (151504093 - 151568944)

Ensembl ID

ENSG00000086570  (ver. 103.38)

Orthologs

Mouse Fat2: ENSMUSG00000055333

UniProt

Q9NYQ8

neXtProt

NX_Q9NYQ8

Human splice variants
Mouse splice variants

Protein structure