RFX2

This gene is a member of the regulatory factor X gene family, which encodes transcription factors that contain a highly-conserved winged helix DNA binding domain. The protein encoded by this gene is structurally related to regulatory factors X1, X3, X4, and X5. It is a transcriptional activator that can bind DNA as a monomer or as a heterodimer with other RFX family members. This protein can bind to cis elements in the promoter of the IL-5 receptor alpha gene. Two transcript variants encoding different isoforms have been described for this gene, and both variants utilize alternative polyadenylation sites. [provided by RefSeq, Jul 2008]

Description

Regulatory factor X2

Tissue specificity

Tissue enhanced (testis)

Subcell location

Nucleoplasm, Golgi apparatus, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Kim et al 2014)
Transcription factors

Chromosome

19 (5993164 - 6199572)

Ensembl ID

ENSG00000087903  (ver. 103.38)

Orthologs

Mouse Rfx2: ENSMUSG00000024206

UniProt

P48378

neXtProt

NX_P48378

Human splice variants
Mouse splice variants

Protein structure