TRMT6

This gene encodes a member of the tRNA methyltransferase 6 protein family. A similar protein in yeast is part of a two component methyltransferase, which is involved in the posttranslational modification that produces the modified nucleoside 1-methyladenosine in tRNAs. Modified 1-methyladenosine influences initiator methionine stability and may be involved in the replication of human immunodeficiency virus type 1. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jul 2013]

Description

TRNA methyltransferase 6

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cell Junctions

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

20 (5937228 - 5950558)

Ensembl ID

ENSG00000089195  (ver. 103.38)

Orthologs

Mouse Trmt6: ENSMUSG00000037376

UniProt

Q9UJA5

neXtProt

NX_Q9UJA5

Human splice variants
Mouse splice variants

Protein structure