NOS1

The protein encoded by this gene belongs to the family of nitric oxide synthases, which synthesize nitric oxide from L-arginine. Nitric oxide is a reactive free radical, which acts as a biologic mediator in several processes, including neurotransmission, and antimicrobial and antitumoral activities. In the brain and peripheral nervous system, nitric oxide displays many properties of a neurotransmitter, and has been implicated in neurotoxicity associated with stroke and neurodegenerative diseases, neural regulation of smooth muscle, including peristalsis, and penile erection. This protein is ubiquitously expressed, with high level of expression in skeletal muscle. Multiple transcript variants that differ in the 5' UTR have been described for this gene but the full-length nature of these transcripts is not known. Additionally, alternatively spliced transcript variants encoding different isoforms (some testis-specific) have been found for this gene. [provided by RefSeq, Feb 2011]

Description

Nitric oxide synthase 1

Tissue specificity

Group enriched (brain, skeletal muscle, tongue)

Subcell location

Nucleoplasm, Plasma membrane

Predicted location

Intracellular

Protein family

Cancer-related genes
Enzymes
FDA approved drug targets
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

12 (117208142 - 117452170)

Ensembl ID

ENSG00000089250  (ver. 103.38)

Orthologs

Mouse Nos1: ENSMUSG00000029361

UniProt

P29475

neXtProt

NX_P29475

Human splice variants
Mouse splice variants

Protein structure