MAP3K20

This gene is a member of the MAPKKK family of signal transduction molecules and encodes a protein with an N-terminal kinase catalytic domain, followed by a leucine zipper motif and a sterile-alpha motif (SAM). This magnesium-binding protein forms homodimers and is located in the cytoplasm. The protein mediates gamma radiation signaling leading to cell cycle arrest and activity of this protein plays a role in cell cycle checkpoint regulation in cells. The protein also has pro-apoptotic activity. Alternate transcriptional splice variants, encoding different isoforms, have been characterized. [provided by RefSeq, Jul 2008]

Description

Mitogen-activated protein kinase kinase kinase 20

Tissue specificity

Tissue enhanced (skeletal muscle, tongue)

Subcell location

Cytosol

Predicted location

Intracellular

Protein family

Disease related genes
Enzymes
Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Metabolic proteins
Potential drug targets
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

2 (173075435 - 173268015)

Ensembl ID

ENSG00000091436  (ver. 103.38)

Orthologs

Mouse Map3k20: ENSMUSG00000004085

UniProt

Q9NYL2

neXtProt

NX_Q9NYL2

Human splice variants
Mouse splice variants

Protein structure