Tissue expression
Cell line expression
Protein structure
ESR1
Estrogen receptor 1ER-alpha, Era, ESR, NR3A1
This gene encodes an estrogen receptor and ligand-activated transcription factor. The canonical protein contains an N-terminal ligand-independent transactivation domain, a central DNA binding domain, a hinge domain, and a C-terminal ligand-dependent transactivation domain. The protein localizes to the nucleus where it may form either a homodimer or a heterodimer with estrogen receptor 2. The protein encoded by this gene regulates the transcription of many estrogen-inducible genes that play a role in growth, metabolism, sexual development, gestation, and other reproductive functions and is expressed in many non-reproductive tissues. The receptor encoded by this gene plays a key role in breast cancer, endometrial cancer, and osteoporosis. This gene is reported to have dozens of transcript variants due to the use of alternate promoters and alternative splicing, however, the full-length nature of many of these variants remain uncertain. [provided by RefSeq, Jul 2020]
Top validated antibodies |
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Invitrogen Antibodies | MA1-27107 | 46 references | Monoclonal |
WB
ICC
IHC
ChIP
OA
|
|
GeneTex | GTX22746 | 1 references | Monoclonal |
WB
ICC
IP
IHC
FC
GS |
|
Atlas Antibodies | HPA000449 | 1 references | Polyclonal |
WB
ICC
IHC
|
|
NSJ Bioreagents | V7564 | Monoclonal |
ICC
IHC
FC
PA
OA
|
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Proteintech Group | 21244-1-AP | 69 references | Polyclonal |
WB
EL
IHC
|
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Supportive data in Antibodypedia
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Recommended by provider