CRTAC1

This gene encodes a glycosylated extracellular matrix protein that is found in the interterritorial matrix of articular deep zone cartilage. This protein is used as a marker to distinguish chondrocytes from osteoblasts and mesenchymal stem cells in culture. The presence of FG-GAP motifs and an RGD integrin-binding motif suggests that this protein may be involved in cell-cell or cell-matrix interactions. Copy number alterations in this gene have been observed in neurofibromatosis type 1-associated glomus tumors. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Aug 2011]

Description

Cartilage acidic protein 1

Tissue specificity

Tissue enhanced (brain, fallopian tube, lung, seminal vesicle)

Predicted location

Intracellular, Secreted to extracellular matrix

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted secreted proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

10 (97865000 - 98030828)

Ensembl ID

ENSG00000095713  (ver. 103.38)

Orthologs

Mouse Crtac1: ENSMUSG00000042401

UniProt

Q9NQ79

neXtProt

NX_Q9NQ79

Human splice variants
Mouse splice variants

Protein structure