ITPR3

This gene encodes a receptor for inositol 1,4,5-trisphosphate, a second messenger that mediates the release of intracellular calcium. The receptor contains a calcium channel at the C-terminus and the ligand-binding site at the N-terminus. Knockout studies in mice suggest that type 2 and type 3 inositol 1,4,5-trisphosphate receptors play a key role in exocrine secretion underlying energy metabolism and growth. [provided by RefSeq, Aug 2010]

Description

Inositol 1,4,5-trisphosphate receptor type 3

Tissue specificity

Low tissue specificity

Subcell location

Vesicles

Predicted location

Membrane

Protein family

Human disease related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

6 (33620365 - 33696574)

Ensembl ID

ENSG00000096433  (ver. 103.38)

Orthologs

Mouse Itpr3: ENSMUSG00000042644

UniProt

Q14573

neXtProt

NX_Q14573

Human splice variants
Mouse splice variants

Protein structure