Tissue expression
Cell line expression
Protein structure
ABL1
ABL proto-oncogene 1, non-receptor tyrosine kinaseABL, c-ABL, JTK7, p150
This gene is a protooncogene that encodes a protein tyrosine kinase involved in a variety of cellular processes, including cell division, adhesion, differentiation, and response to stress. The activity of the protein is negatively regulated by its SH3 domain, whereby deletion of the region encoding this domain results in an oncogene. The ubiquitously expressed protein has DNA-binding activity that is regulated by CDC2-mediated phosphorylation, suggesting a cell cycle function. This gene has been found fused to a variety of translocation partner genes in various leukemias, most notably the t(9;22) translocation that results in a fusion with the 5' end of the breakpoint cluster region gene (BCR; MIM:151410). Alternative splicing of this gene results in two transcript variants, which contain alternative first exons that are spliced to the remaining common exons. [provided by RefSeq, Aug 2014]
Top validated antibodies |
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Invitrogen Antibodies | MA5-14395 | 5 references | Monoclonal |
WB
ICC
IP
IHC |
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GeneTex | GTX111317 | 1 references | Polyclonal |
WB
ICC
IHC
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antibodies-online | ABIN2839560 | 5 references | Polyclonal |
WB
ICC
IHC
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LSBio | LS-C353897 | Polyclonal |
WB
ICC
IHC
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Novus Biologicals | NBP2-49695 | Monoclonal |
WB
ICC
IP
IHC |
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Supportive data in Antibodypedia
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Recommended by provider