EFNA2

This gene encodes a member of the ephrin family. The protein is composed of a signal sequence, a receptor-binding region, a spacer region, and a hydrophobic region. The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. Posttranslational modifications determine whether this protein localizes to the nucleus or the cytoplasm. [provided by RefSeq, Jul 2008]

Description

Ephrin A2

Tissue specificity

Tissue enhanced (intestine, liver)

Subcell location

Mitochondria, Cytosol

Predicted location

Intracellular

Protein family

Cancer-related genes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins
RAS pathway related proteins

Chromosome

19 (1285873 - 1301431)

Ensembl ID

ENSG00000099617  (ver. 103.38)

Orthologs

Mouse Efna2: ENSMUSG00000003070

UniProt

O43921

neXtProt

NX_O43921

Human splice variants
Mouse splice variants

Protein structure