CARD10

The caspase recruitment domain (CARD) is a protein module that consists of 6 or 7 antiparallel alpha helices. It participates in apoptosis signaling through highly specific protein-protein homophilic interactions. Like several other CARD proteins, CARD10 belongs to the membrane-associated guanylate kinase (MAGUK) family and activates NF-kappa-B (NFKB; see MIM 164011) through BCL10 (MIM 603517) (Wang et al., 2001 [PubMed 11259443]). [supplied by OMIM, Mar 2008]

Description

Caspase recruitment domain family member 10

Tissue specificity

Tissue enhanced (intestine)

Subcell location

Vesicles, Intermediate filaments, Cytosol

Predicted location

Intracellular

Protein family

Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)

Chromosome

22 (37490362 - 37519542)

Ensembl ID

ENSG00000100065  (ver. 103.38)

Orthologs

Mouse Card10: ENSMUSG00000033170

UniProt

Q9BWT7

neXtProt

NX_Q9BWT7

Human splice variants
Mouse splice variants

Protein structure