APOBEC3H

This gene encodes a member of the apolipoprotein B mRNA-editing enzyme catalytic polypeptide 3 family of proteins. The encoded protein is a cytidine deaminase that has antiretroviral activity by generating lethal hypermutations in viral genomes. Polymorphisms and alternative splicing in this gene influence its antiretroviral activity and are associated with increased resistence to human immunodeficiency virus type 1 infection in certain populations. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Oct 2009]

Description

Apolipoprotein B mRNA editing enzyme catalytic subunit 3H

Tissue specificity

Low tissue specificity

Subcell location

Nucleoplasm, Cytosol

Predicted location

Intracellular

Protein family

Enzymes
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Predicted intracellular proteins

Chromosome

22 (39097224 - 39104067)

Ensembl ID

ENSG00000100298  (ver. 103.38)

Orthologs

Mouse Apobec3: ENSMUSG00000009585

UniProt

Q6NTF7

neXtProt

NX_Q6NTF7

Human splice variants
Mouse splice variants

Protein structure