SIRPB1

The protein encoded by this gene is a member of the signal-regulatory-protein (SIRP) family, and also belongs to the immunoglobulin superfamily. SIRP family members are receptor-type transmembrane glycoproteins known to be involved in the negative regulation of receptor tyrosine kinase-coupled signaling processes. This protein was found to interact with TYROBP/DAP12, a protein bearing immunoreceptor tyrosine-based activation motifs. This protein was also reported to participate in the recruitment of tyrosine kinase SYK. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Feb 2009]

Description

Signal regulatory protein beta 1

Tissue specificity

Tissue enhanced (bone marrow, lung, lymphoid tissue)

Subcell location

Vesicles, Centrosome

Predicted location

Intracellular, Membrane

Protein family

CD markers
Mapped to neXtProt
Mapped to UniProt SWISS-PROT
Plasma proteins
Predicted intracellular proteins
Predicted membrane proteins
Protein evidence (Ezkurdia et al 2014)
Protein evidence (Kim et al 2014)
Transporters

Chromosome

20 (1561385 - 1620061)

Ensembl ID

ENSG00000101307  (ver. 103.38)

Orthologs

-

UniProt

Q5TFQ8, O00241

neXtProt

NX_Q5TFQ8, NX_O00241

Human splice variants

Protein structure